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Brian Raught

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TOP 3
Tharan Srikumar; Johnny M Tkach; Kyle Tsui; Harm van Bakel; Brenda J Andrews; Charles Boone; Grant W Brown; Michael Costanzo; Guri Giaever; Erica S Johnson; Megan C Lewicki; Corey Nislow; Brian Raught
Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.
Alex U Singer; Tatiana Skarina; Tharan Srikumar; Xiaohui Xu; Hong Cui; Monique Egler; Lennart Eschen-Lippold; Justin Lee; Brian Raught; Alexei Savchenko; Dierk Scheel; Sebastian Schulze; Ulla Bonas
A pathogen type III effector with a novel E3 ubiquitin ligase architecture.
Guomin Liu; Alexey I Nesvizhskii; Brian Raught; Tharan Srikumar; Mike Tyers; Jianping Zhang; Hyungwon Choi; Jean-Philippe Lambert; Brett Larsen; Anne-Claude Gingras
Using ProHits to store, annotate, and analyze affinity purification-mass spectrometry (AP-MS) data.

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All Publications

2013: Tharan Srikumar; Johnny M Tkach; Kyle Tsui; Harm van Bakel; Brenda J Andrews; Charles Boone; Grant W Brown; Michael Costanzo; Guri Giaever; Erica S Johnson; Megan C Lewicki; Corey Nislow; Brian Raught
Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.
The Journal of cell biology 2013;201(1):145-63.
2013: Alex U Singer; Tatiana Skarina; Tharan Srikumar; Xiaohui Xu; Hong Cui; Monique Egler; Lennart Eschen-Lippold; Justin Lee; Brian Raught; Alexei Savchenko; Dierk Scheel; Sebastian Schulze; Ulla Bonas
A pathogen type III effector with a novel E3 ubiquitin ligase architecture.
PLoS pathogens 2013;9(1):e1003121.
2012: Guomin Liu; Alexey I Nesvizhskii; Brian Raught; Tharan Srikumar; Mike Tyers; Jianping Zhang; Hyungwon Choi; Jean-Philippe Lambert; Brett Larsen; Anne-Claude Gingras
Using ProHits to store, annotate, and analyze affinity purification-mass spectrometry (AP-MS) data.
Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.] 2012;Chapter 8():Unit8.16.
2012: Anne-Claude Gingras; Brian Raught
Beyond hairballs: The use of quantitative mass spectrometry data to understand protein-protein interactions.
FEBS letters 2012;586(17):2723-31.
2012: Yi Sheng; Jonathan Shloush; Tharan Srikumar; John R Walker; Janet W Wan; Sheng Xue; Ryan Doherty; Jenny H Hong; Sung K Kim; Dante Neculai; Brian Raught; Cheryl H Arrowsmith; George V Avvakumov; Sirano Dhe-Paganon
A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Molecular & cellular proteomics : MCP 2012;11(8):329-41.
2011: Marc R Fabian; Filipp Frank; Jonathan Green; Masahiro Morita; Bhushan Nagar; Brian Raught; Maja K Cieplak; Thomas F Duchaine; Tharan Srikumar; Tadashi Yamamoto; Nahum Sonenberg
miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.
Nature structural & molecular biology 2011;18(11):1211-7.
2011: Miklós Békés; John Prudden; Tharan Srikumar; Brian Raught; Michael N Boddy; Guy S Salvesen
The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases.
The Journal of biological chemistry 2011;286(12):10238-47.
2011: Jonathan Shloush; John E Vlassov; Ian Engson; Shili Duan; Vivian Saridakis; Sirano Dhe-Paganon; Brian Raught; Yi Sheng; Cheryl H Arrowsmith
Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.
The Journal of biological chemistry 2011;286(6):4796-808.
2010: Guomin Liu; Jianping Zhang; Brett Larsen; Chris Stark; Ashton Breitkreutz; Zhen-Yuan Lin; Bobby-Joe Breitkreutz; Yongmei Ding; Karen Colwill; Adrian Pasculescu; Tony Pawson; Jeffrey L Wrana; Alexey I Nesvizhskii; Brian Raught; Mike Tyers; Anne-Claude Gingras
ProHits: integrated software for mass spectrometry-based interaction proteomics.
Nature biotechnology 2010;28(10):1015-7.
2010: Yaroslav Sydorskyy; Tharan Srikumar; Stanley M Jeram; Sarah Wheaton; Franco Vizeacoumar; Taras Makhnevych; Yolanda T Chong; Anne-Claude Gingras; Brian Raught
A novel mechanism for SUMO system control: regulated Ulp1 nucleolar sequestration.
Molecular and cellular biology 2010;30(18):4452-62.
2010: Marion Jeanne; Valérie Lallemand-Breitenbach; Omar Ferhi; Marcel Koken; Morgane Le Bras; Stéphanie Duffort; Laurent Peres; Caroline Berthier; Hassane Soilihi; Brian Raught; Hugues de Thé
PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3.
Cancer cell 2010;18(1):88-98.
2010: Michael Bidinosti; Israeli Ran; Maria R Sanchez-Carbente; Yvan Martineau; Anne-Claude Gingras; Christos Gkogkas; Brian Raught; Clive R Bramham; Wayne S Sossin; Mauro Costa-Mattioli; Luc DesGroseillers; Jean-Claude Lacaille; Nahum Sonenberg
Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission.
Molecular cell 2010;37(6):797-808.
2010: Franco Vizeacoumar; Nydia van Dyk; Frederick S Vizeacoumar; Vincent Cheung; Jingjing Li; Yaroslav Sydorskyy; Nicolle Case; Zhijian Li; Alessandro Datti; Corey Nislow; Brian Raught; Zhaolei Zhang; Brendan Frey; Kerry Bloom; Charles Boone; Brenda J Andrews
Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis.
The Journal of cell biology 2010;188(1):69-81.
2010: Stanley M Jeram; Tharan Srikumar; Xiang-Dong Zhang; H Anne Eisenhauer; Richard Rogers; Patrick G A Pedrioli; Michael J Matunis; Brian Raught
An improved SUMmOn-based methodology for the identification of ubiquitin and ubiquitin-like protein conjugation sites identifies novel ubiquitin-like protein chain linkages.
Proteomics 2010;10(2):254-65.
2010: Tharan Srikumar; Stanley M Jeram; Henry Lam; Brian Raught
A ubiquitin and ubiquitin-like protein spectral library.
Proteomics 2010;10(2):337-42.
2009: Stanley M Jeram; Tharan Srikumar; Patrick G A Pedrioli; Brian Raught
Using mass spectrometry to identify ubiquitin and ubiquitin-like protein conjugation sites.
Proteomics 2009;9(4):922-34.
2009: Taras Makhnevych; Yaroslav Sydorskyy; Xiaofeng Xin; Tharan Srikumar; Franco Vizeacoumar; Stanley M Jeram; Zhijian Li; Sondra Bahr; Brenda J Andrews; Charles Boone; Brian Raught
Global map of SUMO function revealed by protein-protein interaction and genetic networks.
Molecular cell 2009;33(1):124-35.
2009: Marilyn Goudreault; Lisa M D'Ambrosio; Michelle J Kean; Michael J Mullin; Brett G Larsen; Amy Sanchez; Sidharth Chaudhry; Ginny I Chen; Frank Sicheri; Alexey I Nesvizhskii; Ruedi Aebersold; Brian Raught; Anne-Claude Gingras
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.
Molecular & cellular proteomics : MCP 2009;8(1):157-71.
2008: Valérie Lallemand-Breitenbach; Marion Jeanne; Shirine Benhenda; NASR Rihab; Ming Lei; Laurent Peres; Jun Zhou; Jun Zhu; Brian Raught; Hugues de Thé
Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway.
Nature cell biology 2008;10(5):547-55.
2008: Andrew J McCluskey; Gregory M K Poon; Eleonora Bolewska-Pedyczak; Tharan Srikumar; Stanley M Jeram; Brian Raught; Jean Gariépy
The catalytic subunit of shiga-like toxin 1 interacts with ribosomal stalk proteins and is inhibited by their conserved C-terminal domain.
Journal of molecular biology 2008;378(2):375-86.
2007: Anne-Claude Gingras; Matthias Gstaiger; Brian Raught; Ruedi Aebersold
Analysis of protein complexes using mass spectrometry.
Nature reviews. Molecular cell biology 2007;8(8):645-54.
2007: Parag Mallick; Markus Schirle; Sharon Chen; Mark R Flory; Hookeun Lee; Daniel Martin; Jeffrey A Ranish; Brian Raught; Robert Schmitt; Thilo Werner; Bernhard Kuster; Ruedi Aebersold
Computational prediction of proteotypic peptides for quantitative proteomics.
Nature biotechnology 2007;25(1):125-31.
2006: Patrick G A Pedrioli; Brian Raught; Xiang-Dong Zhang; Richard Rogers; John Aitchison; Michael J Matunis; Ruedi Aebersold
Automated identification of SUMOylation sites using mass spectrometry and SUMmOn pattern recognition software.
Nature methods 2006;3(7):533-9.
2006: David Shahbazian; Philippe Roux; Virginie Mieulet; Michael S Cohen; Brian Raught; Jack Taunton; John W B Hershey; John Blenis; Mario Pende; Nahum Sonenberg
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.
The EMBO journal 2006;25(12):2781-91.
2006: Nichole L King; Eric Deutsch; Jeffrey A Ranish; Alexey I Nesvizhskii; James S Eddes; Parag Mallick; Jimmy Eng; Frank Desiere; Mark R Flory; Daniel B Martin; Bong Kim; Hookeun Lee; Brian Raught; Ruedi Aebersold
Analysis of the Saccharomyces cerevisiae proteome with PeptideAtlas.
Genome biology 2006;7(11):R106.
2005: Yuri V Svitkin; Barbara Herdy; Mauro Costa-Mattioli; Anne-Claude Gingras; Brian Raught; Nahum Sonenberg
Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation.
Molecular and cellular biology 2005;25(23):10556-65.
2005: Anne-Claude Gingras; Michael Caballero; Marcel Zarske; Amy Sanchez; Tony R Hazbun; Stanley Fields; Nahum Sonenberg; Ernst Hafen; Brian Raught; Ruedi Aebersold
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.
Molecular & cellular proteomics : MCP 2005;4(11):1725-40.
2005: Anne-Claude Gingras; Ruedi Aebersold; Brian Raught
Advances in protein complex analysis using mass spectrometry.
The Journal of physiology 2005;563(Pt 1):11-21.
2005: Eugene C Yi; Xiao-Jun Li; Kelly Cooke; Hookeun Lee; Brian Raught; Andrew Page; Victoria Aneliunas; Philip Hieter; David R Goodlett; Ruedi Aebersold
Increased quantitative proteome coverage with (13)C/(12)C-based, acid-cleavable isotope-coded affinity tag reagent and modified data acquisition scheme.
Proteomics 2005;5(2):380-7.
2004: Patrick G A Pedrioli; Jimmy K Eng; Robert Hubley; Mathijs Vogelzang; Eric Deutsch; Brian Raught; Brian Pratt; Erik Nilsson; Ruth Hogue Angeletti; Rolf Apweiler; Kei Cheung; Catherine E Costello; Henning Hermjakob; Sequin Huang; Randall K Julian; Eugene Kapp; Mark E McComb; Stephen G Oliver; Gilbert S Omenn; Norman W Paton; Richard Simpson; Richard Smith; Christopher Taylor; Weimin Zhu; Ruedi Aebersold
A common open representation of mass spectrometry data and its application to proteomics research.
Nature biotechnology 2004;22(11):1459-66.
2004: Brian Raught; Franck Peiretti; Anne-Claude Gingras; Mark Livingstone; David Shahbazian; Greg L Mayeur; Roberto D Polakiewicz; Nahum Sonenberg; John W B Hershey
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.
The EMBO journal 2004;23(8):1761-9.
2004: Anne-Claude Gingras; Brian Raught; Nahum Sonenberg
mTOR signaling to translation.
Current topics in microbiology and immunology 2004;279():169-97.
2003: Hui Qin; Brian Raught; Nahum Sonenberg; Elaine G Goldstein; Arthur M Edelman
Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I.
The Journal of biological chemistry 2003;278(49):48570-9.
2002: Jing Deng; Heather P Harding; Brian Raught; Anne-Claude Gingras; Juan Jose Berlanga; Donalyn Scheuner; Randal J Kaufman; David Ron; Nahum Sonenberg
Activation of GCN2 in UV-irradiated cells inhibits translation.
Current biology : CB 2002;12(15):1279-86.
2002: Pascal E D Lachance; Mathieu Miron; Brian Raught; Nahum Sonenberg; Paul Lasko
Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth.
Molecular and cellular biology 2002;22(6):1656-63.
2001: Anne-Claude Gingras; Brian Raught; SP Gygi; Anna Niedzwiecka; Mathieu Miron; Stephen K Burley; Roberto D Polakiewicz; Aleksandra Wyslouch-Cieszynska; R Aebersold; Nahum Sonenberg
Hierarchical phosphorylation of the translation inhibitor 4E-BP1.
Genes & development 2001;15(21):2852-64.
2001: Valentina Evdokimova; Peter Ruzanov; Hiroaki Imataka; Brian Raught; Yuri V Svitkin; Lev P Ovchinnikov; Nahum Sonenberg
The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer.
The EMBO journal 2001;20(19):5491-502.
2001: Brian Raught; Anne-Claude Gingras; Nahum Sonenberg
The target of rapamycin (TOR) proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7037-44.
2001: Anne-Claude Gingras; Brian Raught; Nahum Sonenberg
Regulation of translation initiation by FRAP/mTOR.
Genes & development 2001;15(7):807-26.
2001: Anne-Claude Gingras; Brian Raught; Nahum Sonenberg
Control of translation by the target of rapamycin proteins.
Progress in molecular and subcellular biology 2001;27():143-74.
2000: Brian Raught; Anne-Claude Gingras; SP Gygi; Hiroaki Imataka; Shigenobu Morino; Alessandra Gradi; R Aebersold; Nahum Sonenberg
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.
The EMBO journal 2000;19(3):434-44.
1999: Anne-Claude Gingras; SP Gygi; Brian Raught; Roberto D Polakiewicz; R T Abraham; M F Hoekstra; R Aebersold; Nahum Sonenberg
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
Genes & development 1999;13(11):1422-37.
1999: Anne-Claude Gingras; Brian Raught; Nahum Sonenberg
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
Annual review of biochemistry 1999;68():913-63.
1999: Brian Raught; Anne-Claude Gingras
eIF4E activity is regulated at multiple levels.
The international journal of biochemistry & cell biology 1999;31(1):43-57.
1998: Alessandra Gradi; Hiroaki Imataka; Yuri V Svitkin; E Rom; Brian Raught; Shigenobu Morino; Nahum Sonenberg
A novel functional human eukaryotic translation initiation factor 4G.
Molecular and cellular biology 1998;18(1):334-42.
1996: Brian Raught; Anne-Claude Gingras; A James; Daniel Medina; Nahum Sonenberg; Jeffrey M Rosen
Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells.
Cancer research 1996;56(19):4382-6.
1996: Jeffrey M Rosen; S Li; Brian Raught; D Hadsell
The mammary gland as a bioreactor: factors regulating the efficient expression of milk protein-based transgenes.
The American journal of clinical nutrition 1996;63(4):627S-32S.
1996: M Dajee; A V Kazansky; Brian Raught; GM Hocke; Georg H Fey; JoAnne S Richards
Prolactin induction of the alpha 2-Macroglobulin gene in rat ovarian granulosa cells: stat 5 activation and binding to the interleukin-6 response element.
Molecular endocrinology (Baltimore, Md.) 1996;10(2):171-84.
1995: A V Kazansky; Brian Raught; S M Lindsey; Y F Wang; Jeffrey M Rosen
Regulation of mammary gland factor/Stat5a during mammary gland development.
Molecular endocrinology (Baltimore, Md.) 1995;9(11):1598-609.
1995: Brian Raught; Warren S-L Liao; Jeffrey M Rosen
Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression.
Molecular endocrinology (Baltimore, Md.) 1995;9(9):1223-32.
1994: Brian Raught; B Khursheed; A Kazansky; J Rosen
YY1 represses beta-casein gene expression by preventing the formation of a lactation-associated complex.
Molecular and cellular biology 1994;14(3):1752-63.
1994: Jeffrey M Rosen; Robin Humphreys; S Krnacik; P Juo; Brian Raught
The regulation of mammary gland development by hormones, growth factors, and oncogenes.
Progress in clinical and biological research 1994;387():95-111.