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Frank Raushel

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Siddhesh S Kamat; Mrinmoy Chakrabarti; Lawrence J Dangott; Howard J Williams; Frank M Raushel
The catalytic mechanism for aerobic formation of methane by bacteria.
Swapnil V Ghodge; Brandan Hillerich; Steven C Almo; Alexander A Fedorov; Elena V Fedorov; Ronald Seidel; Frank M Raushel
Structural and mechanistic characterization of L-histidinol phosphate phosphatase from the polymerase and histidinol phosphatase family of proteins.
Hao Fan; Brandan Hillerich; Daniel S Hitchcock; Henry Lin; Andrej Sali; Ronald D Seidel; Brian K Shoichet; Steven C Almo; Frank M Raushel
Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking.

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All Publications

2013: Siddhesh S Kamat; Mrinmoy Chakrabarti; Lawrence J Dangott; Howard J Williams; Frank M Raushel
The catalytic mechanism for aerobic formation of methane by bacteria.
Nature 2013;497(7447):132-6.
2013: Swapnil V Ghodge; Brandan Hillerich; Steven C Almo; Alexander A Fedorov; Elena V Fedorov; Ronald Seidel; Frank M Raushel
Structural and mechanistic characterization of L-histidinol phosphate phosphatase from the polymerase and histidinol phosphatase family of proteins.
Biochemistry 2013;52(6):1101-12.
2013: Hao Fan; Brandan Hillerich; Daniel S Hitchcock; Henry Lin; Andrej Sali; Ronald D Seidel; Brian K Shoichet; Steven C Almo; Frank M Raushel
Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking.
Journal of the American Chemical Society 2013;135(2):795-803.
2013: Merlin Eric Hobbs; Devon M Kebodeaux; Tamari Narindoshvili; Steven C Almo; Brandan Hillerich; Ronald D Seidel; Matthew W Vetting; Howard J Williams; Frank M Raushel
Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily.
Biochemistry 2013;52(1):239-53.
2013: Argentina Ornelas; Sugadev Ragumani; Magdalena Korczynska; Desigan Kumaran; Tamari Narindoshvili; Brian K Shoichet; Subramanyam Swaminathan; Frank M Raushel
Functional annotation and three-dimensional structure of an incorrectly annotated dihydroorotase from cog3964 in the amidohydrolase superfamily.
Biochemistry 2013;52(1):228-38.
2013: Andrew N Bigley; Frank M Raushel
Catalytic mechanisms for phosphotriesterases.
Biochimica et biophysica acta 2013;1834(1):443-53.
2012: Ping-Chuan Tsai; David P Barondeau; Andrew N Bigley; Nicholas Fox; Steven P Harvey; Frank M Raushel
Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents.
Biochemistry 2012;51(32):6463-75.
2012: Fan Fan; Taylor L Graham; Ruth Lehr; Hongwei Qi; Frank M Raushel; Benjamin Schwartz; Howard J Williams; Huizhen Zhao; Joseph G Boyer; Thomas D Meek
On the catalytic mechanism of human ATP citrate lyase.
Biochemistry 2012;51(25):5198-211.
2012: Merlin Eric Hobbs; Vladimir N Malashkevich; Steven C Almo; Stephen K Burley; J Michael Sauder; Howard J Williams; Chengfu Xu; Frank M Raushel
Structure and catalytic mechanism of LigI: insight into the amidohydrolase enzymes of cog3618 and lignin degradation.
Biochemistry 2012;51(16):3497-507.
2012: Dao Feng Xiang; Chengfu Xu; Brian Shoichet; Howard J Williams; Steven C Almo; Alexander A Fedorov; Elena V Fedorov; Peter Kolb; Tamari Narindoshivili; Frank M Raushel
Structure-based function discovery of an enzyme for the hydrolysis of phosphorylated sugar lactones.
Biochemistry 2012;51(8):1762-73.
2011: Siddhesh S Kamat; Desigan Kumaran; Paul A Lindahl; Ashima Bagaria; Kevin Bain; Stephen K Burley; Spencer Emtage; Tarun Gheyi; Chris Groshong; Gregory P Holmes-Hampton; J Michael Sauder; Subramanyam Swaminathan; Shane E Tichy; Xiaojing Zheng; Frank M Raushel
The catalase activity of diiron adenine deaminase.
Protein science : a publication of the Protein Society 2011;20(12):2080-94.
2011: John Alan Gerlt; Heidi J Imker; Matthew P Jacobson; Wladek Minor; C Dale Poulter; Frank M Raushel; Andrej Sali; Brian K Shoichet; Karen N Allen; Steven C Almo; Richard N Armstrong; Patricia C Babbitt; John E Cronan; Debra Dunaway-Mariano; Jonathan V Sweedler
The Enzyme Function Initiative.
Biochemistry 2011;50(46):9950-62.
2011: Alissa M Goble; Hao Fan; Andrej Sali; Frank M Raushel
Discovery of a cytokinin deaminase.
ACS chemical biology 2011;6(10):1036-40.
2011: Alissa M Goble; J Michael Sauder; Subramanyam Swaminathan; Zhening Zhang; Stephen K Burley; Frank M Raushel
Pa0148 from Pseudomonas aeruginosa catalyzes the deamination of adenine.
Biochemistry 2011;50(30):6589-97.
2011: Daniel S Hitchcock; Steven C Almo; Lawrence J Dangott; Alexander A Fedorov; Elena V Fedorov; Frank M Raushel
Rescue of the orphan enzyme isoguanine deaminase.
Biochemistry 2011;50(25):5555-7.
2011: Richard Hall; Alexander A Fedorov; Chengfu Xu; Elena V Fedorov; Steven C Almo; Frank M Raushel
Three-dimensional structure and catalytic mechanism of cytosine deaminase.
Biochemistry 2011;50(22):5077-85.
2011: Siddhesh S Kamat; Ashima Bagaria; Desigan Kumaran; Gregory P Holmes-Hampton; Hao Fan; Andrej Sali; J Michael Sauder; Stephen K Burley; Paul A Lindahl; Subramanyam Swaminathan; Frank M Raushel
Catalytic mechanism and three-dimensional structure of adenine deaminase.
Biochemistry 2011;50(11):1917-27.
2011: Siddhesh S Kamat; Hao Fan; J Michael Sauder; Stephen K Burley; Brian Shoichet; Andrej Sali; Frank M Raushel
Enzymatic deamination of the epigenetic base N-6-methyladenine.
Journal of the American Chemical Society 2011;133(7):2080-3.
2011: Frank M Raushel
Chemical biology: Catalytic detoxification.
Nature 2011;469(7330):310-1.
2010: Megan E Meyer; Jemy A Gutierrez; Frank M Raushel; Nigel G J Richards
A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase.
Biochemistry 2010;49(43):9391-401.
2010: Ping-Chuan Tsai; Andrew Bigley; Yingchun Li; Eman Ghanem; C Linn Cadieux; Shane A Kasten; Tony E Reeves; Douglas M Cerasoli; Frank M Raushel
Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase.
Biochemistry 2010;49(37):7978-87.
2010: Ping-Chuan Tsai; Yubo Fan; Jungwook Kim; Lijiang Yang; Steven C Almo; Yi Qin Gao; Frank M Raushel
Structural determinants for the stereoselective hydrolysis of chiral substrates by phosphotriesterase.
Biochemistry 2010;49(37):7988-97.
2010: Dao Feng Xiang; Yury Patskovsky; Chengfu Xu; Alexander A Fedorov; Elena V Fedorov; Abby A Sisco; J Michael Sauder; Stephen K Burley; Steven C Almo; Frank M Raushel
Functional identification and structure determination of two novel prolidases from cog1228 in the amidohydrolase superfamily .
Biochemistry 2010;49(31):6791-803.
2010: Richard Hall; Rakhi Agarwal; Daniel Hitchcock; J Michael Sauder; Stephen K Burley; Subramanyam Swaminathan; Frank M Raushel
Discovery and structure determination of the orphan enzyme isoxanthopterin deaminase .
Biochemistry 2010;49(20):4374-82.
2010: Liliya Lund; Yubo Fan; Qiang Shao; Yi Qin Gao; Frank M Raushel
Carbamate transport in carbamoyl phosphate synthetase: a theoretical and experimental investigation.
Journal of the American Chemical Society 2010;132(11):3870-8.
2010: Richard Hall; Alexander A Fedorov; Ricardo Marti-Arbona; Elena V Fedorov; Peter Kolb; J Michael Sauder; Stephen K Burley; Brian Shoichet; Steven C Almo; Frank M Raushel
The hunt for 8-oxoguanine deaminase.
Journal of the American Chemical Society 2010;132(6):1762-3.
2010: Jennifer A Cummings; Tinh T Nguyen; Alexander A Fedorov; Peter Kolb; Chengfu Xu; Elena V Fedorov; Brian Shoichet; David P Barondeau; Steven C Almo; Frank M Raushel
Structure, mechanism, and substrate profile for Sco3058: the closest bacterial homologue to human renal dipeptidase .
Biochemistry 2010;49(3):611-22.
2009: Tinh T Nguyen; Alexander A Fedorov; Lakenya Williams; Elena V Fedorov; Yingchun Li; Chengfu Xu; Steven C Almo; Frank M Raushel
The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Biochemistry 2009;48(37):8879-90.
2009: Yubo Fan; Liliya Lund; Qiang Shao; Yi Qin Gao; Frank M Raushel
A combined theoretical and experimental study of the ammonia tunnel in carbamoyl phosphate synthetase.
Journal of the American Chemical Society 2009;131(29):10211-9.
2009: Jennifer A Cummings; Alexander A Fedorov; Chengfu Xu; Shoshana Brown; Elena V Fedorov; Patricia C Babbitt; Steven C Almo; Frank M Raushel
Annotating enzymes of uncertain function: the deacylation of D-amino acids by members of the amidohydrolase superfamily.
Biochemistry 2009;48(27):6469-81.
2009: Dao Feng Xiang; Chengfu Xu; Desigan Kumaran; Ann C Brown; J Michael Sauder; Stephen K Burley; Subramanyam Swaminathan; Frank M Raushel
Functional annotation of two new carboxypeptidases from the amidohydrolase superfamily of enzymes.
Biochemistry 2009;48(21):4567-76.
2009: Dao Feng Xiang; Yury Patskovsky; Chengfu Xu; Amanda J Meyer; J Michael Sauder; Stephen K Burley; Steven C Almo; Frank M Raushel
Functional identification of incorrectly annotated prolidases from the amidohydrolase superfamily of enzymes.
Biochemistry 2009;48(17):3730-42.
2009: Ursula Pieper; Ranyee Chiang; Jennifer J Seffernick; Shoshana D Brown; Margaret E Glasner; Libusha Kelly; Narayanan Eswar; J Michael Sauder; Jeffrey B Bonanno; Subramanyam Swaminathan; Stephen K Burley; Xiaojing Zheng; Mark R Chance; Steven C Almo; John Alan Gerlt; Frank M Raushel; Matthew P Jacobson; Patricia C Babbitt; Andrej Sali
Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies.
Journal of structural and functional genomics 2009;10(2):107-25.
2009: Dao Feng Xiang; Peter Kolb; Alexander A Fedorov; Monika M Meier; Lena V Fedorov; T Tinh Nguyen; Reinhard Sterner; Steven C Almo; Brian Shoichet; Frank M Raushel
Functional annotation and three-dimensional structure of Dr0930 from Deinococcus radiodurans, a close relative of phosphotriesterase in the amidohydrolase superfamily.
Biochemistry 2009;48(10):2237-47.
2008: Jungwook Kim; Ping-Chuan Tsai; Shi-Lu Chen; Fahmi Himo; Steven C Almo; Frank M Raushel
Structure of diethyl phosphate bound to the binuclear metal center of phosphotriesterase.
Biochemistry 2008;47(36):9497-504.
2008: Rajiv Tyagi; Subramaniam Eswaramoorthy; Stephen K Burley; Frank M Raushel; Subramanyam Swaminathan
A common catalytic mechanism for proteins of the HutI family.
Biochemistry 2008;47(20):5608-15.
2008: Reinhard Sterner; Rainer Merkl; Frank M Raushel
Computational design of enzymes.
Chemistry & biology 2008;15(5):421-3.
2008: LaKenya Williams; Fan Fan; John S Blanchard; Frank M Raushel
Positional isotope exchange analysis of the Mycobacterium smegmatis cysteine ligase (MshC).
Biochemistry 2008;47(16):4843-50.
2008: Yubo Fan; Liliya Lund; Lijiang Yang; Frank M Raushel; Yi Qin Gao
Mechanism for the transport of ammonia within carbamoyl phosphate synthetase determined by molecular dynamics simulations.
Biochemistry 2008;47(9):2935-44.
2008: Tinh T Nguyen; Shoshana Brown; Alexander A Fedorov; Elena V Fedorov; Patricia C Babbitt; Steven C Almo; Frank M Raushel
At the periphery of the amidohydrolase superfamily: Bh0493 from Bacillus halodurans catalyzes the isomerization of D-galacturonate to D-tagaturonate.
Biochemistry 2008;47(4):1194-206.
2008: Rong-Zhen Liao; Jian-Guo Yu; Frank M Raushel; Fahmi Himo
Theoretical investigation of the reaction mechanism of the dinuclear zinc enzyme dihydroorotase.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(14):4287-92.
2007: Vicente Fresquet; LaKenya Williams; Frank M Raushel
Partial randomization of the four sequential amidation reactions catalyzed by cobyric acid synthetase with a single point mutation.
Biochemistry 2007;46(49):13983-93.
2007: Johannes C Hermann; Ricardo Marti-Arbona; Alexander A Fedorov; Elena V Fedorov; Steven C Almo; Brian Shoichet; Frank M Raushel
Structure-based activity prediction for an enzyme of unknown function.
Nature 2007;448(7155):775-9.
2007: Eman Ghanem; Yingchun Li; Chengfu Xu; Frank M Raushel
Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX.
Biochemistry 2007;46(31):9032-40.
2007: Richard Hall; Shoshana Brown; Alexander A Fedorov; Elena V Fedorov; Chengfu Xu; Patricia C Babbitt; Steven C Almo; Frank M Raushel
Structural diversity within the mononuclear and binuclear active sites of N-acetyl-D-glucosamine-6-phosphate deacetylase.
Biochemistry 2007;46(27):7953-62.
2007: Richard Hall; Dao Feng Xiang; Chengfu Xu; Frank M Raushel
N-Acetyl-D-glucosamine-6-phosphate deacetylase: substrate activation via a single divalent metal ion.
Biochemistry 2007;46(27):7942-52.
2007: Cynthia R Samples; Frank M Raushel; Victoria J DeRose
Activation of the binuclear metal center through formation of phosphotriesterase-inhibitor complexes.
Biochemistry 2007;46(11):3435-42.
2007: LaKenya Williams; Vicente Fresquet; Patricio J Santander; Frank M Raushel
The multiple amidation reactions catalyzed by Cobyric acid synthetase from Salmonella typhimurium are sequential and dissociative.
Journal of the American Chemical Society 2007;129(2):294-5.
2007: Gheorghe Proteasa; Yahya R Tahboub; Semira Galijasevic; Frank M Raushel; Husam M Abu-Soud
Kinetic evidence supports the existence of two halide binding sites that have a distinct impact on the heme iron microenvironment in myeloperoxidase.
Biochemistry 2007;46(2):398-405.
2006: Charity Nowlan; Yingchun Li; Johannes C Hermann; Timothy Evans; Joseph Carpenter; Eman Ghanem; Brian Shoichet; Frank M Raushel
Resolution of chiral phosphate, phosphonate, and phosphinate esters by an enantioselective enzyme library.
Journal of the American Chemical Society 2006;128(49):15892-902.
2006: Johannes C Hermann; Eman Ghanem; Yingchun Li; Frank M Raushel; John J Irwin; Brian Shoichet
Predicting substrates by docking high-energy intermediates to enzyme structures.
Journal of the American Chemical Society 2006;128(49):15882-91.
2006: Ricardo Martí-Arbona; Frank M Raushel
Mechanistic characterization of N-formimino-L-glutamate iminohydrolase from Pseudomonas aeruginosa.
Biochemistry 2006;45(48):14256-62.
2006: Amanda Weeks; Liliya Lund; Frank M Raushel
Tunneling of intermediates in enzyme-catalyzed reactions.
Current opinion in chemical biology 2006;10(5):465-72.
2006: LaKenya Williams; Tinh Nguyen; Yingchun Li; Tamiko N Porter; Frank M Raushel
Uronate isomerase: a nonhydrolytic member of the amidohydrolase superfamily with an ambivalent requirement for a divalent metal ion.
Biochemistry 2006;45(24):7453-62.
2006: Ayano Sakai; Dao Feng Xiang; Chengfu Xu; Ling Song; Wen Shan Yew; Frank M Raushel; John Alan Gerlt
Evolution of enzymatic activities in the enolase superfamily: N-succinylamino acid racemase and a new pathway for the irreversible conversion of D- to L-amino acids.
Biochemistry 2006;45(14):4455-62.
2006: Chengfu Xu; Richard Hall; Jennifer Cummings; Frank M Raushel
Tight binding inhibitors of N-acyl amino sugar and N-acyl amino acid deacetylases.
Journal of the American Chemical Society 2006;128(13):4244-5.
2006: Ricardo Martí-Arbona; Chengfu Xu; Sondra Steele; Amanda Weeks; Gabriel F Kuty; Clara M Seibert; Frank M Raushel
Annotating enzymes of unknown function: N-formimino-L-glutamate deiminase is a member of the amidohydrolase superfamily.
Biochemistry 2006;45(7):1997-2005.
2006: Yaroslav Korpan; Frank M Raushel; Elena A Nazarenko; Alexey P Soldatkin; Nicole Jaffrezic-Renault; Claude Martelet
Sensitivity and specificity improvement of an ion sensitive field effect transistors-based biosensor for potato glycoalkaloids detection.
Journal of agricultural and food chemistry 2006;54(3):707-12.
2005: Ricardo Martí-Arbona; James B Thoden; Hazel M Holden; Frank M Raushel
Functional significance of Glu-77 and Tyr-137 within the active site of isoaspartyl dipeptidase.
Bioorganic chemistry 2005;33(6):448-58.
2005: Yingchun Li; Frank M Raushel
Inhibitors designed for the active site of dihydroorotase.
Bioorganic chemistry 2005;33(6):470-83.
2005: John J Irwin; Frank M Raushel; Brian Shoichet
Virtual screening against metalloenzymes for inhibitors and substrates.
Biochemistry 2005;44(37):12316-28.
2005: Eman Ghanem; Frank M Raushel
Detoxification of organophosphate nerve agents by bacterial phosphotriesterase.
Toxicology and applied pharmacology 2005;207(2 Suppl):459-70.
2005: Cynthia R Samples; Timothy Howard; Frank M Raushel; Victoria J DeRose
Protonation of the binuclear metal center within the active site of phosphotriesterase.
Biochemistry 2005;44(33):11005-13.
2005: Ricardo Martí-Arbona; Vicente Fresquet; James B Thoden; Melissa L Davis; Hazel M Holden; Frank M Raushel
Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli.
Biochemistry 2005;44(19):7115-24.
2005: Clara M Seibert; Frank M Raushel
Structural and catalytic diversity within the amidohydrolase superfamily.
Biochemistry 2005;44(17):6383-91.
2004: Tamiko N Porter; Yingchun Li; Frank M Raushel
Mechanism of the dihydroorotase reaction.
Biochemistry 2004;43(51):16285-92.
2004: Min-Sun Park; Craig M Hill; Yingchun Li; R Kristoffer Hardy; Hemant Khanna; Yong-Ho Khang; Frank M Raushel
Catalytic properties of the PepQ prolidase from Escherichia coli.
Archives of biochemistry and biophysics 2004;429(2):224-30.
2004: Husam M Abu-Soud; Frank M Raushel; Stanley L Hazen
A novel multistep mechanism for oxygen binding to ferrous hemoproteins: rapid kinetic analysis of ferrous-dioxy myeloperoxidase (compound III) formation.
Biochemistry 2004;43(36):11589-95.
2004: James B Thoden; Xinyi Huang; Jungwook Kim; Frank M Raushel; Hazel M Holden
Long-range allosteric transitions in carbamoyl phosphate synthetase.
Protein science : a publication of the Protein Society 2004;13(9):2398-405.
2004: Vicente Fresquet; LaKenya Williams; Frank M Raushel
Mechanism of cobyrinic acid a,c-diamide synthetase from Salmonella typhimurium LT2.
Biochemistry 2004;43(33):10619-27.
2004: Yingchun Li; Sarah D Aubert; Eugene G Maes; Frank M Raushel
Enzymatic resolution of chiral phosphinate esters.
Journal of the American Chemical Society 2004;126(29):8888-9.
2004: Sarah D Aubert; Yingchun Li; Frank M Raushel
Mechanism for the hydrolysis of organophosphates by the bacterial phosphotriesterase.
Biochemistry 2004;43(19):5707-15.
2004: Jungwook Kim; Frank M Raushel
Perforation of the tunnel wall in carbamoyl phosphate synthetase derails the passage of ammonia between sequential active sites.
Biochemistry 2004;43(18):5334-40.
2004: Jungwook Kim; Frank M Raushel
Access to the carbamate tunnel of carbamoyl phosphate synthetase.
Archives of biochemistry and biophysics 2004;425(1):33-41.
2004: Vicente Fresquet; James B Thoden; Hazel M Holden; Frank M Raushel
Kinetic mechanism of asparagine synthetase from Vibrio cholerae.
Bioorganic chemistry 2004;32(2):63-75.
2004: Suk-Bong Hong; Frank M Raushel
Control of stereoselectivity in phosphotriesterase.
Methods in enzymology 2004;388():256-66.
2003: James B Garrett; Leisha S Mullins; Frank M Raushel
Effect of linker sequence on the stability of circularly permuted variants of ribonuclease T1.
Bioorganic chemistry 2003;31(5):412-24.
2003: Karin T Lum; Henry J Huebner; Yingchun Li; Timothy D Phillips; Frank M Raushel
Organophosphate nerve agent toxicity in Hydra attenuata.
Chemical research in toxicology 2003;16(8):953-7.
2003: Craig M Hill; Wen-Shan Li; James B Thoden; Hazel M Holden; Frank M Raushel
Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.
Journal of the American Chemical Society 2003;125(30):8990-1.
2003: Frank M Raushel; James B Thoden; Hazel M Holden
Enzymes with molecular tunnels.
Accounts of chemical research 2003;36(7):539-48.
2003: Yingchun Li; Sarah D Aubert; Frank M Raushel
Operational control of stereoselectivity during the enzymatic hydrolysis of racemic organophosphorus compounds.
Journal of the American Chemical Society 2003;125(25):7526-7.
2003: LaKenya Williams; Renjian Zheng; John S Blanchard; Frank M Raushel
Positional isotope exchange analysis of the pantothenate synthetase reaction.
Biochemistry 2003;42(17):5108-13.
2003: James B Thoden; Ricardo Marti-Arbona; Frank M Raushel; Hazel M Holden
High-resolution X-ray structure of isoaspartyl dipeptidase from Escherichia coli.
Biochemistry 2003;42(17):4874-82.
2003: James B Thoden; Jungwook Kim; Frank M Raushel; Hazel M Holden
The catalytic mechanism of galactose mutarotase.
Protein science : a publication of the Protein Society 2003;12(5):1051-9.
2003: John Alan Gerlt; Frank M Raushel
Evolution of function in (beta/alpha)8-barrel enzymes.
Current opinion in chemical biology 2003;7(2):252-64.
2002: James B Thoden; Jungwook Kim; Frank M Raushel; Hazel M Holden
Structural and kinetic studies of sugar binding to galactose mutarotase from Lactococcus lactis.
The Journal of biological chemistry 2002;277(47):45458-65.
2002: Jungwook Kim; Stanley Howell; Xinyi Huang; Frank M Raushel
Structural defects within the carbamate tunnel of carbamoyl phosphate synthetase.
Biochemistry 2002;41(42):12575-81.
2002: James B Thoden; Xinyi Huang; Frank M Raushel; Hazel M Holden
Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia.
The Journal of biological chemistry 2002;277(42):39722-7.
2002: Frank M Raushel
Bacterial detoxification of organophosphate nerve agents.
Current opinion in microbiology 2002;5(3):288-95.
2002: Wen-Shan Li; Yingchun Li; Craig M Hill; Karin T Lum; Frank M Raushel
Enzymatic synthesis of chiral organophosphothioates from prochiral precursors.
Journal of the American Chemical Society 2002;124(14):3498-9.
2002: Olivier A Pierrat; Frank M Raushel
A functional analysis of the allosteric nucleotide monophosphate binding site of carbamoyl phosphate synthetase.
Archives of biochemistry and biophysics 2002;400(1):34-42.
2002: Olivier A Pierrat; Farah Javid-Majd; Frank M Raushel
Dissection of the conduit for allosteric control of carbamoyl phosphate synthetase by ornithine.
Archives of biochemistry and biophysics 2002;400(1):26-33.
2002: Bryant W Miles; James B Thoden; Hazel M Holden; Frank M Raushel
Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin.
The Journal of biological chemistry 2002;277(6):4368-73.
2001: M A Anderson; H Shim; Frank M Raushel; W Wallace Cleland
Hydrolysis of phosphotriesters: determination of transition states in parallel reactions by heavy-atom isotope effects.
Journal of the American Chemical Society 2001;123(38):9246-53.
2001: Jungwook Kim; Frank M Raushel
Allosteric control of the oligomerization of carbamoyl phosphate synthetase from Escherichia coli.
Biochemistry 2001;40(37):11030-6.
2001: Wen-Shan Li; Karin T Lum; M Chen-Goodspeed; MA Sogorb; Frank M Raushel
Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase.
Bioorganic & medicinal chemistry 2001;9(8):2083-91.
2001: James B Thoden; George N Phillips; T M Neal; Frank M Raushel; Hazel M Holden
Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.
Biochemistry 2001;40(24):6989-97.
2001: Matthew M Benning; H Shim; Frank M Raushel; Hazel M Holden
High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.
Biochemistry 2001;40(9):2712-22.
2001: M Chen-Goodspeed; MA Sogorb; F Wu; Frank M Raushel
Enhancement, relaxation, and reversal of the stereoselectivity for phosphotriesterase by rational evolution of active site residues.
Biochemistry 2001;40(5):1332-9.
2001: M Chen-Goodspeed; MA Sogorb; F Wu; SB Hong; Frank M Raushel
Structural determinants of the substrate and stereochemical specificity of phosphotriesterase.
Biochemistry 2001;40(5):1325-31.
2001: Craig M Hill; Wen-Shan Li; Tu-Chen Cheng; Joseph J DeFrank; Frank M Raushel
Stereochemical specificity of organophosphorus acid anhydrolase toward p-nitrophenyl analogs of soman and sarin.
Bioorganic chemistry 2001;29(1):27-35.
2000: Matthew M Benning; S B Hong; Frank M Raushel; Hazel M Holden
The binding of substrate analogs to phosphotriesterase.
The Journal of biological chemistry 2000;275(39):30556-60.
2000: X Huang; Frank M Raushel
Restricted passage of reaction intermediates through the ammonia tunnel of carbamoyl phosphate synthetase.
The Journal of biological chemistry 2000;275(34):26233-40.
2000: Xinyi Huang; Frank M Raushel
Role of the hinge loop linking the N- and C-terminal domains of the amidotransferase subunit of carbamoyl phosphate synthetase.
Archives of biochemistry and biophysics 2000;380(1):174-80.
2000: H Shim; Frank M Raushel
Self-assembly of the binuclear metal center of phosphotriesterase.
Biochemistry 2000;39(25):7357-64.
2000: Craig M Hill; F Wu; Tu-Chen Cheng; Joseph J DeFrank; Frank M Raushel
Substrate and stereochemical specificity of the organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 toward p-nitrophenyl phosphotriesters.
Bioorganic & medicinal chemistry letters 2000;10(11):1285-8.
2000: B W Miles; Frank M Raushel
Synchronization of the three reaction centers within carbamoyl phosphate synthetase.
Biochemistry 2000;39(17):5051-6.
2000: Xinyi Huang; Frank M Raushel
An engineered blockage within the ammonia tunnel of carbamoyl phosphate synthetase prevents the use of glutamine as a substrate but not ammonia.
Biochemistry 2000;39(12):3240-7.
2000: Farah Javid-Majd; LS Mullins; Frank M Raushel; M A Stapleton
The differentially conserved residues of carbamoyl-phosphate synthetase.
The Journal of biological chemistry 2000;275(7):5073-80.
2000: Frank M Raushel; Hazel M Holden
Phosphotriesterase: an enzyme in search of its natural substrate.
Advances in enzymology and related areas of molecular biology 2000;74():51-93.
1999: James B Thoden; Xinyi Huang; Frank M Raushel; Hazel M Holden
The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry 1999;38(49):16158-66.
1999: Xinyi Huang; Frank M Raushel
Deconstruction of the catalytic array within the amidotransferase subunit of carbamoyl phosphate synthetase.
Biochemistry 1999;38(48):15909-14.
1999: Hazel M Holden; James B Thoden; Frank M Raushel
Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product.
Cellular and molecular life sciences : CMLS 1999;56(5-6):507-22.
1999: James B Thoden; Frank M Raushel; Gary E Wesenberg; Hazel M Holden
The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase.
The Journal of biological chemistry 1999;274(32):22502-7.
1999: Frank M Raushel; James B Thoden; Hazel M Holden
The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.
Biochemistry 1999;38(25):7891-9.
1999: SB Hong; Frank M Raushel
Stereochemical preferences for chiral substrates by the bacterial phosphotriesterase.
Chemico-biological interactions 1999;119-120():225-34.
1999: James B Thoden; Gary E Wesenberg; Frank M Raushel; Hazel M Holden
Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding.
Biochemistry 1999;38(8):2347-57.
1999: B L Braxton; LS Mullins; Frank M Raushel; Gregory D Reinhart
Allosteric dominance in carbamoyl phosphate synthetase.
Biochemistry 1999;38(5):1394-401.
1999: SB Hong; Frank M Raushel
Stereochemical constraints on the substrate specificity of phosphotriesterase.
Biochemistry 1999;38(4):1159-65.
1999: James B Thoden; Frank M Raushel; Matthew M Benning; Ivan Rayment; Hazel M Holden
The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):8-24.
1998: Hazel M Holden; James B Thoden; Frank M Raushel
Carbamoyl phosphate synthetase: a tunnel runs through it.
Current opinion in structural biology 1998;8(6):679-85.
1998: B W Miles; J A Banzon; Frank M Raushel
Regulatory control of the amidotransferase domain of carbamoyl phosphate synthetase.
Biochemistry 1998;37(47):16773-9.
1998: Frank M Raushel; James B Thoden; Gregory D Reinhart; Hazel M Holden
Carbamoyl phosphate synthetase: a crooked path from substrates to products.
Current opinion in chemical biology 1998;2(5):624-32.
1998: Frank M Raushel; LS Mullins; G E Gibson
A stringent test for the nucleotide switch mechanism of carbamoyl phosphate synthetase.
Biochemistry 1998;37(28):10272-8.
1998: H Shim; SB Hong; Frank M Raushel
Hydrolysis of phosphodiesters through transformation of the bacterial phosphotriesterase.
The Journal of biological chemistry 1998;273(28):17445-50.
1998: James B Thoden; S G Miran; J C Phillips; A J Howard; Frank M Raushel; Hazel M Holden
Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis.
Biochemistry 1998;37(25):8825-31.
1998: W A Francisco; Husam M Abu-Soud; A J DelMonte; Daniel A Singleton; Thomas O Baldwin; Frank M Raushel
Deuterium kinetic isotope effects and the mechanism of the bacterial luciferase reaction.
Biochemistry 1998;37(8):2596-606.
1997: L M Watkins; J M Kuo; M Chen-Goodspeed; Frank M Raushel
A combinatorial library for the binuclear metal center of bacterial phosphotriesterase.
Proteins 1997;29(4):553-61.
1997: L M Watkins; H J Mahoney; J K McCulloch; Frank M Raushel
Augmented hydrolysis of diisopropyl fluorophosphate in engineered mutants of phosphotriesterase.
The Journal of biological chemistry 1997;272(41):25596-601.
1997: SB Hong; Frank M Raushel
Inhibitors directed towards the binuclear metal center of phosphotriesterase.
Journal of enzyme inhibition 1997;12(3):191-203.
1997: SB Hong; LS Mullins; H Shim; Frank M Raushel
Mechanism-based inhibitors for the inactivation of the bacterial phosphotriesterase.
Biochemistry 1997;36(29):9022-8.
1997: L S Mullins; C N Pace; Frank M Raushel
Conformational stability of ribonuclease T1 determined by hydrogen-deuterium exchange.
Protein science : a publication of the Protein Society 1997;6(7):1387-95.
1997: James B Thoden; Hazel M Holden; Gary E Wesenberg; Frank M Raushel; Ivan Rayment
Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product.
Biochemistry 1997;36(21):6305-16.
1997: J M Kuo; M Y Chae; Frank M Raushel
Perturbations to the active site of phosphotriesterase.
Biochemistry 1997;36(8):1982-8.
1996: F Javid-Majd; M A Stapleton; M F Harmon; B A Hanks; LS Mullins; Frank M Raushel
Comparison of the functional differences for the homologous residues within the carboxy phosphate and carbamate domains of carbamoyl phosphate synthetase.
Biochemistry 1996;35(45):14362-9.
1996: M A Stapleton; F Javid-Majd; M F Harmon; B A Hanks; J L Grahmann; LS Mullins; Frank M Raushel
Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase.
Biochemistry 1996;35(45):14352-61.
1996: B L Braxton; LS Mullins; Frank M Raushel; Gregory D Reinhart
Allosteric effects of carbamoyl phosphate synthetase from Escherichia coli are entropy-driven.
Biochemistry 1996;35(36):11918-24.
1996: S B Hong; Frank M Raushel
Metal-substrate interactions facilitate the catalytic activity of the bacterial phosphotriesterase.
Biochemistry 1996;35(33):10904-12.
1996: J L Johnson; Frank M Raushel
Influence of primary sequence transpositions on the folding pathways of ribonuclease T1.
Biochemistry 1996;35(31):10223-33.
1996: Janeen L Vanhooke; Matthew M Benning; Frank M Raushel; Hazel M Holden
Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4-methylbenzylphosphonate.
Biochemistry 1996;35(19):6020-5.
1996: J B Garrett; LS Mullins; Frank M Raushel
Are turns required for the folding of ribonuclease T1?
Protein science : a publication of the Protein Society 1996;5(2):204-11.
1996: W A Francisco; Husam M Abu-Soud; R Topgi; Thomas O Baldwin; Frank M Raushel
Interaction of bacterial luciferase with 8-substituted flavin mononucleotide derivatives.
The Journal of biological chemistry 1996;271(1):104-10.
1995: Thomas O Baldwin; J A Christopher; Frank M Raushel; J F Sinclair; M M Ziegler; A J Fisher; Ivan Rayment
Structure of bacterial luciferase.
Current opinion in structural biology 1995;5(6):798-809.
1995: R M Czerwinski; S M Mareya; Frank M Raushel
Regulatory changes in the control of carbamoyl phosphate synthetase induced by truncation and mutagenesis of the allosteric binding domain.
Biochemistry 1995;34(42):13920-7.
1995: James B Thoden; Frank M Raushel; S Mareya; D Tomchick; Ivan Rayment
Crystallization and preliminary X-ray crystallographic analysis of carbamoyl phosphate synthetase from Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):827-9.
1995: Matthew M Benning; J M Kuo; Frank M Raushel; Hazel M Holden
Three-dimensional structure of the binuclear metal center of phosphotriesterase.
Biochemistry 1995;34(25):7973-8.
1995: A J Fisher; Frank M Raushel; Thomas O Baldwin; Ivan Rayment
Three-dimensional structure of bacterial luciferase from Vibrio harveyi at 2.4 A resolution.
Biochemistry 1995;34(20):6581-6.
1995: S M Mareya; Frank M Raushel
Mapping the structural domains of E. coli carbamoyl phosphate synthetase using limited proteolysis.
Bioorganic & medicinal chemistry 1995;3(5):525-32.
1995: M Y Chae; G A Omburo; Paul A Lindahl; Frank M Raushel
Utilization of copper as a paramagnetic probe for the binuclear metal center of phosphotriesterase.
Archives of biochemistry and biophysics 1995;316(2):765-72.
1995: J A Banzon; J M Kuo; D R Fischer; P J Stang; Frank M Raushel
Histidine-254 is essential for the inactivation of phosphotriesterase with the alkynyl phosphate esters and diethyl pyrocarbonate.
Biochemistry 1995;34(3):750-4.
1995: J A Banzon; J M Kuo; B W Miles; D R Fischer; P J Stang; Frank M Raushel
Mechanism-based inactivation of phosphotriesterase by reaction of a critical histidine with a ketene intermediate.
Biochemistry 1995;34(3):743-9.
1995: LS Mullins; Frank M Raushel
Positional isotope exchange as probe of enzyme action.
Methods in enzymology 1995;249():398-425.
1994: Matthew M Benning; J M Kuo; Frank M Raushel; Hazel M Holden
Three-dimensional structure of phosphotriesterase: an enzyme capable of detoxifying organophosphate nerve agents.
Biochemistry 1994;33(50):15001-7.
1994: J M Kuo; Frank M Raushel
Identification of the histidine ligands to the binuclear metal center of phosphotriesterase by site-directed mutagenesis.
Biochemistry 1994;33(14):4265-72.
1994: S M Mareya; Frank M Raushel
A molecular wedge for triggering the amidotransferase activity of carbamoyl phosphate synthetase.
Biochemistry 1994;33(10):2945-50.
1994: L Pei; G Omburo; W David McGuinn; I Petrikovics; K Dave; Frank M Raushel; James R Wild; J R DeLoach; J L Way
Encapsulation of phosphotriesterase within murine erythrocytes.
Toxicology and applied pharmacology 1994;124(2):296-301.
1993: W A Francisco; Husam M Abu-Soud; Thomas O Baldwin; Frank M Raushel
Interaction of bacterial luciferase with aldehyde substrates and inhibitors.
The Journal of biological chemistry 1993;268(33):24734-41.
1993: G A Omburo; LS Mullins; Frank M Raushel
Structural characterization of the divalent cation sites of bacterial phosphotriesterase by 113Cd NMR spectroscopy.
Biochemistry 1993;32(35):9148-55.
1993: LS Mullins; C Nick Pace; Frank M Raushel
Investigation of ribonuclease T1 folding intermediates by hydrogen-deuterium amide exchange-two-dimensional NMR spectroscopy.
Biochemistry 1993;32(24):6152-6.
1993: Husam M Abu-Soud; A C Clark; W A Francisco; Thomas O Baldwin; Frank M Raushel
Kinetic destabilization of the hydroperoxy flavin intermediate by site-directed modification of the reactive thiol in bacterial luciferase.
The Journal of biological chemistry 1993;268(11):7699-706.
1993: B W Miles; S M Mareya; L E Post; D J Post; S H Chang; Frank M Raushel
Differential roles for three conserved histidine residues within the large subunit of carbamoyl phosphate synthetase.
Biochemistry 1993;32(1):232-40.
1992: G A Omburo; J M Kuo; LS Mullins; Frank M Raushel
Characterization of the zinc binding site of bacterial phosphotriesterase.
The Journal of biological chemistry 1992;267(19):13278-83.
1992: Husam M Abu-Soud; LS Mullins; Thomas O Baldwin; Frank M Raushel
Stopped-flow kinetic analysis of the bacterial luciferase reaction.
Biochemistry 1992;31(15):3807-13.
1992: B L Braxton; LS Mullins; Frank M Raushel; Gregory D Reinhart
Quantifying the allosteric properties of Escherichia coli carbamyl phosphate synthetase: determination of thermodynamic linked-function parameters in an ordered kinetic mechanism.
Biochemistry 1992;31(8):2309-16.
1991: S R Caldwell; Frank M Raushel
Detoxification of organophosphate pesticides using a nylon based immobilized phosphotriesterase from Pseudomonas diminuta.
Applied biochemistry and biotechnology 1991;31(1):59-73.
1991: S G Miran; S H Chang; Frank M Raushel
Role of the four conserved histidine residues in the amidotransferase domain of carbamoyl phosphate synthetase.
Biochemistry 1991;30(32):7901-7.
1991: S R Caldwell; Frank M Raushel; P M Weiss; W W Cleland
Transition-state structures for enzymatic and alkaline phosphotriester hydrolysis.
Biochemistry 1991;30(30):7444-50.
1991: S R Caldwell; J R Newcomb; K A Schlecht; Frank M Raushel
Limits of diffusion in the hydrolysis of substrates by the phosphotriesterase from Pseudomonas diminuta.
Biochemistry 1991;30(30):7438-44.
1991: LS Mullins; C J Lusty; Frank M Raushel
Alterations in the energetics of the carbamoyl phosphate synthetase reaction by site-directed modification of the essential sulfhydryl group.
The Journal of biological chemistry 1991;266(13):8236-40.
1990: D P Dumas; Frank M Raushel
Chemical and kinetic evidence for an essential histidine in the phosphotriesterase from Pseudomonas diminuta.
The Journal of biological chemistry 1990;265(35):21498-503.
1990: M McNutt; LS Mullins; Frank M Raushel; C Nick Pace
Contribution of histidine residues to the conformational stability of ribonuclease T1 and mutant Glu-58----Ala.
Biochemistry 1990;29(33):7572-6.
1990: D P Dumas; James R Wild; Frank M Raushel
Expression of Pseudomonas phosphotriesterase activity in the fall armyworm confers resistance to insecticides.
Experientia 1990;46(7):729-31.
1990: LS Mullins; L E Zawadzke; C T Walsh; Frank M Raushel
Kinetic evidence for the formation of D-alanyl phosphate in the mechanism of D-alanyl-D-alanine ligase.
The Journal of biological chemistry 1990;265(16):8993-8.
1990: D P Dumas; H D Durst; W G Landis; Frank M Raushel; James R Wild
Inactivation of organophosphorus nerve agents by the phosphotriesterase from Pseudomonas diminuta.
Archives of biochemistry and biophysics 1990;277(1):155-9.
1989: D P Dumas; S R Caldwell; James R Wild; Frank M Raushel
Purification and properties of the phosphotriesterase from Pseudomonas diminuta.
The Journal of biological chemistry 1989;264(33):19659-65.
1989: Frank M Raushel; Thomas O Baldwin
Proposed mechanism for the bacterial bioluminescence reaction involving a dioxirane intermediate.
Biochemical and biophysical research communications 1989;164(3):1137-42.
1989: W J Donarski; D P Dumas; D P Heitmeyer; V E Lewis; Frank M Raushel
Structure-activity relationships in the hydrolysis of substrates by the phosphotriesterase from Pseudomonas diminuta.
Biochemistry 1989;28(11):4650-5.
1988: S C Kim; A N Singh; Frank M Raushel
Analysis of the galactosyltransferase reaction by positional isotope exchange and secondary deuterium isotope effects.
Archives of biochemistry and biophysics 1988;267(1):54-9.
1988: S C Kim; Frank M Raushel
Mechanism-based inactivation of rabbit muscle phosphoglucomutase by nojirimycin 6-phosphate.
Biochemistry 1988;27(19):7328-32.
1988: S C Kim; A N Singh; Frank M Raushel
The mechanism of glycogen synthetase as determined by deuterium isotope effects and positional isotope exchange experiments.
The Journal of biological chemistry 1988;263(21):10151-4.
1988: V E Lewis; W J Donarski; James R Wild; Frank M Raushel
Mechanism and stereochemical course at phosphorus of the reaction catalyzed by a bacterial phosphotriesterase.
Biochemistry 1988;27(5):1591-7.
1988: S C Kim; Frank M Raushel
The interaction of monofluorofumarate with adenylosuccinate lyase.
Journal of enzyme inhibition 1988;2(3):153-61.
1987: L S Hester; Frank M Raushel
Determination of the energetics of the UDP-glucose pyrophosphorylase reaction by positional isotope exchange inhibition.
Biochemistry 1987;26(20):6465-71.