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Frank Raushel

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
27
Holden, Hazel
23
Thoden, James
17
Mullins, LS
13
Li, Yingchun
9
Almo, Steven
9
Xu, Chengfu
8
Baldwin, Thomas
6
Benning, Matthew
6
Hong, SB
6
Fedorov, Alexander
6
Williams, LaKenya
5
Wild, James
5
Fedorov, Elena
5
Fresquet, Vicente
5
Hill, Craig

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Publications

TOP 3
Nguyen Tinh T; Fedorov Alexander A; Williams Lakenya; Fedorov Elena V; Li Yingchun; Xu Chengfu; Almo Steven C; Raushel Frank M
The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Fan Yubo; Lund Liliya; Shao Qiang; Gao Yi-Qin; Raushel Frank M
A combined theoretical and experimental study of the ammonia tunnel in carbamoyl phosphate synthetase.
Cummings Jennifer A; Fedorov Alexander A; Xu Chengfu; Brown Shoshana; Fedorov Elena; Babbitt Patricia C; Almo Steven C; Raushel Frank M
Annotating enzymes of uncertain function: the deacylation of D-amino acids by members of the amidohydrolase superfamily.

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All Publications

2009: Nguyen Tinh T; Fedorov Alexander A; Williams Lakenya; Fedorov Elena V; Li Yingchun; Xu Chengfu; Almo Steven C; Raushel Frank M
The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Biochemistry 2009;48(37):8879-90.
2009: Fan Yubo; Lund Liliya; Shao Qiang; Gao Yi-Qin; Raushel Frank M
A combined theoretical and experimental study of the ammonia tunnel in carbamoyl phosphate synthetase.
Journal of the American Chemical Society 2009;131(29):10211-9.
2009: Cummings Jennifer A; Fedorov Alexander A; Xu Chengfu; Brown Shoshana; Fedorov Elena; Babbitt Patricia C; Almo Steven C; Raushel Frank M
Annotating enzymes of uncertain function: the deacylation of D-amino acids by members of the amidohydrolase superfamily.
Biochemistry 2009;48(27):6469-81.
2009: Xiang Dao Feng; Xu Chengfu; Kumaran Desigan; Brown Ann C; Sauder J Michael; Burley Stephen K; Swaminathan Subramanyam; Raushel Frank M
Functional annotation of two new carboxypeptidases from the amidohydrolase superfamily of enzymes.
Biochemistry 2009;48(21):4567-76.
2009: Xiang Dao Feng; Patskovsky Yury; Xu Chengfu; Meyer Amanda J; Sauder J Michael; Burley Stephen K; Almo Steven C; Raushel Frank M
Functional identification of incorrectly annotated prolidases from the amidohydrolase superfamily of enzymes.
Biochemistry 2009;48(17):3730-42.
2009: Pieper Ursula; Chiang Ranyee; Seffernick Jennifer J; Brown Shoshana D; Glasner Margaret E; Kelly Libusha; Eswar Narayanan; Sauder J Michael; Bonanno Jeffrey B; Swaminathan Subramanyam; Burley Stephen K; Zheng Xiaojing; Chance Mark R; Almo Steven C; Gerlt John A; Raushel Frank M; Jacobson Matthew P; Babbitt Patricia C; Sali Andrej
Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies.
Journal of structural and functional genomics 2009;10(2):107-25.
2009: Xiang Dao Feng; Kolb Peter; Fedorov Alexander A; Meier Monika M; Fedorov Lena V; Nguyen T Tinh; Sterner Reinhard; Almo Steven C; Shoichet Brian K; Raushel Frank M
Functional annotation and three-dimensional structure of Dr0930 from Deinococcus radiodurans, a close relative of phosphotriesterase in the amidohydrolase superfamily.
Biochemistry 2009;48(10):2237-47.
2008: Kim Jungwook; Tsai Ping-Chuan; Chen Shi-Lu; Himo Fahmi; Almo Steven C; Raushel Frank M
Structure of diethyl phosphate bound to the binuclear metal center of phosphotriesterase.
Biochemistry 2008;47(36):9497-504.
2008: Sterner Reinhard; Merkl Rainer; Raushel Frank M
Computational design of enzymes.
Chemistry & biology 2008;15(5):421-3.
2008: Tyagi Rajiv; Eswaramoorthy Subramaniam; Burley Stephen K; Raushel Frank M; Swaminathan Subramanyam
A common catalytic mechanism for proteins of the HutI family.
Biochemistry 2008;47(20):5608-15.
2008: Williams LaKenya; Fan Fan; Blanchard John S; Raushel Frank M
Positional isotope exchange analysis of the Mycobacterium smegmatis cysteine ligase (MshC).
Biochemistry 2008;47(16):4843-50.
2008: Fan Yubo; Lund Liliya; Yang Lijiang; Raushel Frank M; Gao Yi-Qin
Mechanism for the transport of ammonia within carbamoyl phosphate synthetase determined by molecular dynamics simulations.
Biochemistry 2008;47(9):2935-44.
2008: Nguyen Tinh T; Brown Shoshana; Fedorov Alexander A; Fedorov Elena V; Babbitt Patricia C; Almo Steven C; Raushel Frank M
At the periphery of the amidohydrolase superfamily: Bh0493 from Bacillus halodurans catalyzes the isomerization of D-galacturonate to D-tagaturonate.
Biochemistry 2008;47(4):1194-206.
2008: Liao Rong-Zhen; Yu Jian-Guo; Raushel Frank M; Himo Fahmi
Theoretical investigation of the reaction mechanism of the dinuclear zinc enzyme dihydroorotase.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(14):4287-92.
2007: Fresquet Vicente; Williams LaKenya; Raushel Frank M
Partial randomization of the four sequential amidation reactions catalyzed by cobyric acid synthetase with a single point mutation.
Biochemistry 2007;46(49):13983-93.
2007: Ghanem Eman; Li Yingchun; Xu Chengfu; Raushel Frank M
Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX.
Biochemistry 2007;46(31):9032-40.
2007: Hermann Johannes C; Marti-Arbona Ricardo; Fedorov Alexander A; Fedorov Elena; Almo Steven C; Shoichet Brian K; Raushel Frank M
Structure-based activity prediction for an enzyme of unknown function.
Nature 2007;448(7155):775-9.
2007: Hall Richard S; Brown Shoshana; Fedorov Alexander A; Fedorov Elena V; Xu Chengfu; Babbitt Patricia C; Almo Steven C; Raushel Frank M
Structural diversity within the mononuclear and binuclear active sites of N-acetyl-D-glucosamine-6-phosphate deacetylase.
Biochemistry 2007;46(27):7953-62.
2007: Hall Richard S; Xiang Dao Feng; Xu Chengfu; Raushel Frank M
N-Acetyl-D-glucosamine-6-phosphate deacetylase: substrate activation via a single divalent metal ion.
Biochemistry 2007;46(27):7942-52.
2007: Samples Cynthia R; Raushel Frank M; DeRose Victoria J
Activation of the binuclear metal center through formation of phosphotriesterase-inhibitor complexes.
Biochemistry 2007;46(11):3435-42.
2007: Williams Lakenya; Fresquet Vicente; Santander Patricio J; Raushel Frank M
The multiple amidation reactions catalyzed by Cobyric acid synthetase from Salmonella typhimurium are sequential and dissociative.
Journal of the American Chemical Society 2007;129(2):294-5.
2007: Proteasa Gheorghe; Tahboub Yahya R; Galijasevic Semira; Raushel Frank M; Abu-Soud Husam M
Kinetic evidence supports the existence of two halide binding sites that have a distinct impact on the heme iron microenvironment in myeloperoxidase.
Biochemistry 2007;46(2):398-405.
2006: Nowlan Charity; Li Yingchun; Hermann Johannes C; Evans Timothy; Carpenter Joseph; Ghanem Eman; Shoichet Brian K; Raushel Frank M
Resolution of chiral phosphate, phosphonate, and phosphinate esters by an enantioselective enzyme library.
Journal of the American Chemical Society 2006;128(49):15892-902.
2006: Hermann Johannes C; Ghanem Eman; Li Yingchun; Raushel Frank M; Irwin John J; Shoichet Brian K
Predicting substrates by docking high-energy intermediates to enzyme structures.
Journal of the American Chemical Society 2006;128(49):15882-91.
2006: Martí-Arbona Ricardo; Raushel Frank M
Mechanistic characterization of N-formimino-L-glutamate iminohydrolase from Pseudomonas aeruginosa.
Biochemistry 2006;45(48):14256-62.
2006: Weeks Amanda; Lund Liliya; Raushel Frank M
Tunneling of intermediates in enzyme-catalyzed reactions.
Current opinion in chemical biology 2006;10(5):465-72.
2006: Williams LaKenya; Nguyen Tinh; Li Yingchun; Porter Tamiko N; Raushel Frank M
Uronate isomerase: a nonhydrolytic member of the amidohydrolase superfamily with an ambivalent requirement for a divalent metal ion.
Biochemistry 2006;45(24):7453-62.
2006: Sakai Ayano; Xiang Dao Feng; Xu Chengfu; Song Ling; Yew Wen Shan; Raushel Frank M; Gerlt John A
Evolution of enzymatic activities in the enolase superfamily: N-succinylamino acid racemase and a new pathway for the irreversible conversion of D- to L-amino acids.
Biochemistry 2006;45(14):4455-62.
2006: Xu Chengfu; Hall Richard; Cummings Jennifer; Raushel Frank M
Tight binding inhibitors of N-acyl amino sugar and N-acyl amino acid deacetylases.
Journal of the American Chemical Society 2006;128(13):4244-5.
2006: Martí-Arbona Ricardo; Xu Chengfu; Steele Sondra; Weeks Amanda; Kuty Gabriel F; Seibert Clara M; Raushel Frank M
Annotating enzymes of unknown function: N-formimino-L-glutamate deiminase is a member of the amidohydrolase superfamily.
Biochemistry 2006;45(7):1997-2005.
2006: Korpan Yaroslav I; Raushel Frank M; Nazarenko Elena A; Soldatkin Alexey P; Jaffrezic-Renault Nicole; Martelet Claude
Sensitivity and specificity improvement of an ion sensitive field effect transistors-based biosensor for potato glycoalkaloids detection.
Journal of agricultural and food chemistry 2006;54(3):707-12.
2005: Martí-Arbona Ricardo; Thoden James B; Holden Hazel M; Raushel Frank M
Functional significance of Glu-77 and Tyr-137 within the active site of isoaspartyl dipeptidase.
Bioorganic chemistry 2005;33(6):448-58.
2005: Li Yingchun; Raushel Frank M
Inhibitors designed for the active site of dihydroorotase.
Bioorganic chemistry 2005;33(6):470-83.
2005: Irwin John J; Raushel Frank M; Shoichet Brian K
Virtual screening against metalloenzymes for inhibitors and substrates.
Biochemistry 2005;44(37):12316-28.
2005: Ghanem Eman; Raushel Frank M
Detoxification of organophosphate nerve agents by bacterial phosphotriesterase.
Toxicology and applied pharmacology 2005;207(2 Suppl):459-70.
2005: Samples Cynthia R; Howard Timothy; Raushel Frank M; DeRose Victoria J
Protonation of the binuclear metal center within the active site of phosphotriesterase.
Biochemistry 2005;44(33):11005-13.
2005: Martí-Arbona Ricardo; Fresquet Vicente; Thoden James B; Davis Melissa L; Holden Hazel M; Raushel Frank M
Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli.
Biochemistry 2005;44(19):7115-24.
2005: Seibert Clara M; Raushel Frank M
Structural and catalytic diversity within the amidohydrolase superfamily.
Biochemistry 2005;44(17):6383-91.
2004: Porter Tamiko N; Li Yingchun; Raushel Frank M
Mechanism of the dihydroorotase reaction.
Biochemistry 2004;43(51):16285-92.
2004: Abu-Soud Husam M; Raushel Frank M; Hazen Stanley L
A novel multistep mechanism for oxygen binding to ferrous hemoproteins: rapid kinetic analysis of ferrous-dioxy myeloperoxidase (compound III) formation.
Biochemistry 2004;43(36):11589-95.
2004: Thoden James B; Huang Xinyi; Kim Jungwook; Raushel Frank M; Holden Hazel M
Long-range allosteric transitions in carbamoyl phosphate synthetase.
Protein science : a publication of the Protein Society 2004;13(9):2398-405.
2004: Park Min-Sun; Hill Craig M; Li Yingchun; Hardy R Kristoffer; Khanna Hemant; Khang Yong-Ho; Raushel Frank M
Catalytic properties of the PepQ prolidase from Escherichia coli.
Archives of biochemistry and biophysics 2004;429(2):224-30.
2004: Fresquet Vicente; Williams LaKenya; Raushel Frank M
Mechanism of cobyrinic acid a,c-diamide synthetase from Salmonella typhimurium LT2.
Biochemistry 2004;43(33):10619-27.
2004: Li Yingchun; Aubert Sarah D; Maes Eugene G; Raushel Frank M
Enzymatic resolution of chiral phosphinate esters.
Journal of the American Chemical Society 2004;126(29):8888-9.
2004: Aubert Sarah D; Li Yingchun; Raushel Frank M
Mechanism for the hydrolysis of organophosphates by the bacterial phosphotriesterase.
Biochemistry 2004;43(19):5707-15.
2004: Kim Jungwook; Raushel Frank M
Perforation of the tunnel wall in carbamoyl phosphate synthetase derails the passage of ammonia between sequential active sites.
Biochemistry 2004;43(18):5334-40.
2004: Kim Jungwook; Raushel Frank M
Access to the carbamate tunnel of carbamoyl phosphate synthetase.
Archives of biochemistry and biophysics 2004;425(1):33-41.
2004: Fresquet Vicente; Thoden James B; Holden Hazel M; Raushel Frank M
Kinetic mechanism of asparagine synthetase from Vibrio cholerae.
Bioorganic chemistry 2004;32(2):63-75.
2004: Hong Suk-Bong; Raushel Frank M
Control of stereoselectivity in phosphotriesterase.
Methods in enzymology 2004;388():256-66.
2003: Garrett James B; Mullins Leisha S; Raushel Frank M
Effect of linker sequence on the stability of circularly permuted variants of ribonuclease T1.
Bioorganic chemistry 2003;31(5):412-24.
2003: Lum Karin T; Huebner Henry J; Li Yingchun; Phillips Timothy D; Raushel Frank M
Organophosphate nerve agent toxicity in Hydra attenuata.
Chemical research in toxicology 2003;16(8):953-7.
2003: Hill Craig M; Li Wen-Shan; Thoden James B; Holden Hazel M; Raushel Frank M
Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.
Journal of the American Chemical Society 2003;125(30):8990-1.
2003: Raushel Frank M; Thoden James B; Holden Hazel M
Enzymes with molecular tunnels.
Accounts of chemical research 2003;36(7):539-48.
2003: Li Yingchun; Aubert Sarah D; Raushel Frank M
Operational control of stereoselectivity during the enzymatic hydrolysis of racemic organophosphorus compounds.
Journal of the American Chemical Society 2003;125(25):7526-7.
2003: Williams LaKenya; Zheng Renjian; Blanchard John S; Raushel Frank M
Positional isotope exchange analysis of the pantothenate synthetase reaction.
Biochemistry 2003;42(17):5108-13.
2003: Thoden James B; Marti-Arbona Ricardo; Raushel Frank M; Holden Hazel M
High-resolution X-ray structure of isoaspartyl dipeptidase from Escherichia coli.
Biochemistry 2003;42(17):4874-82.
2003: Thoden James B; Kim Jungwook; Raushel Frank M; Holden Hazel M
The catalytic mechanism of galactose mutarotase.
Protein science : a publication of the Protein Society 2003;12(5):1051-9.
2003: Gerlt John A; Raushel Frank M
Evolution of function in (beta/alpha)8-barrel enzymes.
Current opinion in chemical biology 2003;7(2):252-64.
2002: Thoden James B; Kim Jungwook; Raushel Frank M; Holden Hazel M
Structural and kinetic studies of sugar binding to galactose mutarotase from Lactococcus lactis.
The Journal of biological chemistry 2002;277(47):45458-65.
2002: Kim Jungwook; Howell Stanley; Huang Xinyi; Raushel Frank M
Structural defects within the carbamate tunnel of carbamoyl phosphate synthetase.
Biochemistry 2002;41(42):12575-81.
2002: Thoden James B; Huang Xinyi; Raushel Frank M; Holden Hazel M
Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia.
The Journal of biological chemistry 2002;277(42):39722-7.
2002: Raushel Frank M
Bacterial detoxification of organophosphate nerve agents.
Current opinion in microbiology 2002;5(3):288-95.
2002: Li Wen-Shan; Li Yingchun; Hill Craig M; Lum Karin T; Raushel Frank M
Enzymatic synthesis of chiral organophosphothioates from prochiral precursors.
Journal of the American Chemical Society 2002;124(14):3498-9.
2002: Pierrat Olivier A; Raushel Frank M
A functional analysis of the allosteric nucleotide monophosphate binding site of carbamoyl phosphate synthetase.
Archives of biochemistry and biophysics 2002;400(1):34-42.
2002: Pierrat Olivier A; Javid-Majd Farah; Raushel Frank M
Dissection of the conduit for allosteric control of carbamoyl phosphate synthetase by ornithine.
Archives of biochemistry and biophysics 2002;400(1):26-33.
2002: Miles Bryant W; Thoden James B; Holden Hazel M; Raushel Frank M
Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin.
The Journal of biological chemistry 2002;277(6):4368-73.
2001: Anderson M A; Shim H; Raushel F M; Cleland W W
Hydrolysis of phosphotriesters: determination of transition states in parallel reactions by heavy-atom isotope effects.
Journal of the American Chemical Society 2001;123(38):9246-53.
2001: Kim J; Raushel F M
Allosteric control of the oligomerization of carbamoyl phosphate synthetase from Escherichia coli.
Biochemistry 2001;40(37):11030-6.
2001: Li W S; Lum K T; Chen-Goodspeed M; Sogorb M A; Raushel F M
Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase.
Bioorganic & medicinal chemistry 2001;9(8):2083-91.
2001: Thoden J B; Phillips G N; Neal T M; Raushel F M; Holden H M
Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.
Biochemistry 2001;40(24):6989-97.
2001: Benning M M; Shim H; Raushel F M; Holden H M
High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.
Biochemistry 2001;40(9):2712-22.
2001: Hill C M; Li W S; Cheng T C; DeFrank J J; Raushel F M
Stereochemical specificity of organophosphorus acid anhydrolase toward p-nitrophenyl analogs of soman and sarin.
Bioorganic chemistry 2001;29(1):27-35.
2001: Chen-Goodspeed M; Sogorb M A; Wu F; Raushel F M
Enhancement, relaxation, and reversal of the stereoselectivity for phosphotriesterase by rational evolution of active site residues.
Biochemistry 2001;40(5):1332-9.
2001: Chen-Goodspeed M; Sogorb M A; Wu F; Hong S B; Raushel F M
Structural determinants of the substrate and stereochemical specificity of phosphotriesterase.
Biochemistry 2001;40(5):1325-31.
2000: Benning M M; Hong S B; Raushel F M; Holden H M
The binding of substrate analogs to phosphotriesterase.
The Journal of biological chemistry 2000;275(39):30556-60.
2000: Huang X; Raushel F M
Restricted passage of reaction intermediates through the ammonia tunnel of carbamoyl phosphate synthetase.
The Journal of biological chemistry 2000;275(34):26233-40.
2000: Huang X; Raushel F M
Role of the hinge loop linking the N- and C-terminal domains of the amidotransferase subunit of carbamoyl phosphate synthetase.
Archives of biochemistry and biophysics 2000;380(1):174-80.
2000: Hill C M; Wu F; Cheng T C; DeFrank J J; Raushel F M
Substrate and stereochemical specificity of the organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 toward p-nitrophenyl phosphotriesters.
Bioorganic & medicinal chemistry letters 2000;10(11):1285-8.
2000: Shim H; Raushel F M
Self-assembly of the binuclear metal center of phosphotriesterase.
Biochemistry 2000;39(25):7357-64.
2000: Miles B W; Raushel F M
Synchronization of the three reaction centers within carbamoyl phosphate synthetase.
Biochemistry 2000;39(17):5051-6.
2000: Huang X; Raushel F M
An engineered blockage within the ammonia tunnel of carbamoyl phosphate synthetase prevents the use of glutamine as a substrate but not ammonia.
Biochemistry 2000;39(12):3240-7.
2000: Javid-Majd F; Mullins L S; Raushel F M; Stapleton M A
The differentially conserved residues of carbamoyl-phosphate synthetase.
The Journal of biological chemistry 2000;275(7):5073-80.
2000: Raushel F M; Holden H M
Phosphotriesterase: an enzyme in search of its natural substrate.
Advances in enzymology and related areas of molecular biology 2000;74():51-93.
1999: Thoden J B; Huang X; Raushel F M; Holden H M
The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry 1999;38(49):16158-66.
1999: Huang X; Raushel F M
Deconstruction of the catalytic array within the amidotransferase subunit of carbamoyl phosphate synthetase.
Biochemistry 1999;38(48):15909-14.
1999: Holden H M; Thoden J B; Raushel F M
Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product.
Cellular and molecular life sciences : CMLS 1999;56(5-6):507-22.
1999: Thoden J B; Raushel F M; Wesenberg G; Holden H M
The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase.
The Journal of biological chemistry 1999;274(32):22502-7.
1999: Raushel F M; Thoden J B; Holden H M
The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.
Biochemistry 1999;38(25):7891-9.
1999: Hong S B; Raushel F M
Stereochemical preferences for chiral substrates by the bacterial phosphotriesterase.
Chemico-biological interactions 1999;119-120():225-34.
1999: Thoden J B; Wesenberg G; Raushel F M; Holden H M
Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding.
Biochemistry 1999;38(8):2347-57.
1999: Braxton B L; Mullins L S; Raushel F M; Reinhart G D
Allosteric dominance in carbamoyl phosphate synthetase.
Biochemistry 1999;38(5):1394-401.
1999: Thoden J B; Raushel F M; Benning M M; Rayment I; Holden H M
The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):8-24.
1999: Hong S B; Raushel F M
Stereochemical constraints on the substrate specificity of phosphotriesterase.
Biochemistry 1999;38(4):1159-65.
1998: Holden H M; Thoden J B; Raushel F M
Carbamoyl phosphate synthetase: a tunnel runs through it.
Current opinion in structural biology 1998;8(6):679-85.
1998: Miles B W; Banzon J A; Raushel F M
Regulatory control of the amidotransferase domain of carbamoyl phosphate synthetase.
Biochemistry 1998;37(47):16773-9.
1998: Raushel F M; Thoden J B; Reinhart G D; Holden H M
Carbamoyl phosphate synthetase: a crooked path from substrates to products.
Current opinion in chemical biology 1998;2(5):624-32.
1998: Raushel F M; Mullins L S; Gibson G E
A stringent test for the nucleotide switch mechanism of carbamoyl phosphate synthetase.
Biochemistry 1998;37(28):10272-8.
1998: Shim H; Hong S B; Raushel F M
Hydrolysis of phosphodiesters through transformation of the bacterial phosphotriesterase.
The Journal of biological chemistry 1998;273(28):17445-50.
1998: Thoden J B; Miran S G; Phillips J C; Howard A J; Raushel F M; Holden H M
Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis.
Biochemistry 1998;37(25):8825-31.
1998: Francisco W A; Abu-Soud H M; DelMonte A J; Singleton D A; Baldwin T O; Raushel F M
Deuterium kinetic isotope effects and the mechanism of the bacterial luciferase reaction.
Biochemistry 1998;37(8):2596-606.
1997: Watkins L M; Kuo J M; Chen-Goodspeed M; Raushel F M
A combinatorial library for the binuclear metal center of bacterial phosphotriesterase.
Proteins 1997;29(4):553-61.
1997: Watkins L M; Mahoney H J; McCulloch J K; Raushel F M
Augmented hydrolysis of diisopropyl fluorophosphate in engineered mutants of phosphotriesterase.
The Journal of biological chemistry 1997;272(41):25596-601.
1997: Hong S B; Raushel F M
Inhibitors directed towards the binuclear metal center of phosphotriesterase.
Journal of enzyme inhibition 1997;12(3):191-203.
1997: Mullins L S; Pace C N; Raushel F M
Conformational stability of ribonuclease T1 determined by hydrogen-deuterium exchange.
Protein science : a publication of the Protein Society 1997;6(7):1387-95.
1997: Hong S B; Mullins L S; Shim H; Raushel F M
Mechanism-based inhibitors for the inactivation of the bacterial phosphotriesterase.
Biochemistry 1997;36(29):9022-8.
1997: Thoden J B; Holden H M; Wesenberg G; Raushel F M; Rayment I
Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product.
Biochemistry 1997;36(21):6305-16.
1997: Kuo J M; Chae M Y; Raushel F M
Perturbations to the active site of phosphotriesterase.
Biochemistry 1997;36(8):1982-8.
1996: Javid-Majd F; Stapleton M A; Harmon M F; Hanks B A; Mullins L S; Raushel F M
Comparison of the functional differences for the homologous residues within the carboxy phosphate and carbamate domains of carbamoyl phosphate synthetase.
Biochemistry 1996;35(45):14362-9.
1996: Stapleton M A; Javid-Majd F; Harmon M F; Hanks B A; Grahmann J L; Mullins L S; Raushel F M
Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase.
Biochemistry 1996;35(45):14352-61.
1996: Braxton B L; Mullins L S; Raushel F M; Reinhart G D
Allosteric effects of carbamoyl phosphate synthetase from Escherichia coli are entropy-driven.
Biochemistry 1996;35(36):11918-24.
1996: Johnson J L; Raushel F M
Influence of primary sequence transpositions on the folding pathways of ribonuclease T1.
Biochemistry 1996;35(31):10223-33.
1996: Hong S B; Raushel F M
Metal-substrate interactions facilitate the catalytic activity of the bacterial phosphotriesterase.
Biochemistry 1996;35(33):10904-12.
1996: Vanhooke J L; Benning M M; Raushel F M; Holden H M
Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4-methylbenzylphosphonate.
Biochemistry 1996;35(19):6020-5.
1996: Garrett J B; Mullins L S; Raushel F M
Are turns required for the folding of ribonuclease T1?
Protein science : a publication of the Protein Society 1996;5(2):204-11.
1996: Francisco W A; Abu-Soud H M; Topgi R; Baldwin T O; Raushel F M
Interaction of bacterial luciferase with 8-substituted flavin mononucleotide derivatives.
The Journal of biological chemistry 1996;271(1):104-10.
1995: Baldwin T O; Christopher J A; Raushel F M; Sinclair J F; Ziegler M M; Fisher A J; Rayment I
Structure of bacterial luciferase.
Current opinion in structural biology 1995;5(6):798-809.
1995: Czerwinski R M; Mareya S M; Raushel F M
Regulatory changes in the control of carbamoyl phosphate synthetase induced by truncation and mutagenesis of the allosteric binding domain.
Biochemistry 1995;34(42):13920-7.
1995: Thoden J B; Raushel F M; Mareya S; Tomchick D; Rayment I
Crystallization and preliminary X-ray crystallographic analysis of carbamoyl phosphate synthetase from Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):827-9.
1995: Benning M M; Kuo J M; Raushel F M; Holden H M
Three-dimensional structure of the binuclear metal center of phosphotriesterase.
Biochemistry 1995;34(25):7973-8.
1995: Fisher A J; Raushel F M; Baldwin T O; Rayment I
Three-dimensional structure of bacterial luciferase from Vibrio harveyi at 2.4 A resolution.
Biochemistry 1995;34(20):6581-6.
1995: Mareya S M; Raushel F M
Mapping the structural domains of E. coli carbamoyl phosphate synthetase using limited proteolysis.
Bioorganic & medicinal chemistry 1995;3(5):525-32.
1995: Chae M Y; Omburo G A; Lindahl P A; Raushel F M
Utilization of copper as a paramagnetic probe for the binuclear metal center of phosphotriesterase.
Archives of biochemistry and biophysics 1995;316(2):765-72.
1995: Banzon J A; Kuo J M; Fischer D R; Stang P J; Raushel F M
Histidine-254 is essential for the inactivation of phosphotriesterase with the alkynyl phosphate esters and diethyl pyrocarbonate.
Biochemistry 1995;34(3):750-4.
1995: Banzon J A; Kuo J M; Miles B W; Fischer D R; Stang P J; Raushel F M
Mechanism-based inactivation of phosphotriesterase by reaction of a critical histidine with a ketene intermediate.
Biochemistry 1995;34(3):743-9.
1995: Mullins L S; Raushel F M
Positional isotope exchange as probe of enzyme action.
Methods in enzymology 1995;249():398-425.
1994: Benning M M; Kuo J M; Raushel F M; Holden H M
Three-dimensional structure of phosphotriesterase: an enzyme capable of detoxifying organophosphate nerve agents.
Biochemistry 1994;33(50):15001-7.
1994: Kuo J M; Raushel F M
Identification of the histidine ligands to the binuclear metal center of phosphotriesterase by site-directed mutagenesis.
Biochemistry 1994;33(14):4265-72.
1994: Mareya S M; Raushel F M
A molecular wedge for triggering the amidotransferase activity of carbamoyl phosphate synthetase.
Biochemistry 1994;33(10):2945-50.
1994: Pei L; Omburo G; McGuinn W D; Petrikovics I; Dave K; Raushel F M; Wild J R; DeLoach J R; Way J L
Encapsulation of phosphotriesterase within murine erythrocytes.
Toxicology and applied pharmacology 1994;124(2):296-301.
1993: Francisco W A; Abu-Soud H M; Baldwin T O; Raushel F M
Interaction of bacterial luciferase with aldehyde substrates and inhibitors.
The Journal of biological chemistry 1993;268(33):24734-41.
1993: Omburo G A; Mullins L S; Raushel F M
Structural characterization of the divalent cation sites of bacterial phosphotriesterase by 113Cd NMR spectroscopy.
Biochemistry 1993;32(35):9148-55.
1993: Mullins L S; Pace C N; Raushel F M
Investigation of ribonuclease T1 folding intermediates by hydrogen-deuterium amide exchange-two-dimensional NMR spectroscopy.
Biochemistry 1993;32(24):6152-6.
1993: Abu-Soud H M; Clark A C; Francisco W A; Baldwin T O; Raushel F M
Kinetic destabilization of the hydroperoxy flavin intermediate by site-directed modification of the reactive thiol in bacterial luciferase.
The Journal of biological chemistry 1993;268(11):7699-706.
1993: Miles B W; Mareya S M; Post L E; Post D J; Chang S H; Raushel F M
Differential roles for three conserved histidine residues within the large subunit of carbamoyl phosphate synthetase.
Biochemistry 1993;32(1):232-40.
1992: Omburo G A; Kuo J M; Mullins L S; Raushel F M
Characterization of the zinc binding site of bacterial phosphotriesterase.
The Journal of biological chemistry 1992;267(19):13278-83.
1992: Abu-Soud H; Mullins L S; Baldwin T O; Raushel F M
Stopped-flow kinetic analysis of the bacterial luciferase reaction.
Biochemistry 1992;31(15):3807-13.
1992: Braxton B L; Mullins L S; Raushel F M; Reinhart G D
Quantifying the allosteric properties of Escherichia coli carbamyl phosphate synthetase: determination of thermodynamic linked-function parameters in an ordered kinetic mechanism.
Biochemistry 1992;31(8):2309-16.
1991: Caldwell S R; Raushel F M
Detoxification of organophosphate pesticides using a nylon based immobilized phosphotriesterase from Pseudomonas diminuta.
Applied biochemistry and biotechnology 1991;31(1):59-73.
1991: Miran S G; Chang S H; Raushel F M
Role of the four conserved histidine residues in the amidotransferase domain of carbamoyl phosphate synthetase.
Biochemistry 1991;30(32):7901-7.
1991: Caldwell S R; Raushel F M; Weiss P M; Cleland W W
Transition-state structures for enzymatic and alkaline phosphotriester hydrolysis.
Biochemistry 1991;30(30):7444-50.
1991: Caldwell S R; Newcomb J R; Schlecht K A; Raushel F M
Limits of diffusion in the hydrolysis of substrates by the phosphotriesterase from Pseudomonas diminuta.
Biochemistry 1991;30(30):7438-44.
1991: Mullins L S; Lusty C J; Raushel F M
Alterations in the energetics of the carbamoyl phosphate synthetase reaction by site-directed modification of the essential sulfhydryl group.
The Journal of biological chemistry 1991;266(13):8236-40.
1990: Dumas D P; Raushel F M
Chemical and kinetic evidence for an essential histidine in the phosphotriesterase from Pseudomonas diminuta.
The Journal of biological chemistry 1990;265(35):21498-503.
1990: McNutt M; Mullins L S; Raushel F M; Pace C N
Contribution of histidine residues to the conformational stability of ribonuclease T1 and mutant Glu-58----Ala.
Biochemistry 1990;29(33):7572-6.
1990: Dumas D P; Wild J R; Raushel F M
Expression of Pseudomonas phosphotriesterase activity in the fall armyworm confers resistance to insecticides.
Experientia 1990;46(7):729-31.
1990: Mullins L S; Zawadzke L E; Walsh C T; Raushel F M
Kinetic evidence for the formation of D-alanyl phosphate in the mechanism of D-alanyl-D-alanine ligase.
The Journal of biological chemistry 1990;265(16):8993-8.
1990: Dumas D P; Durst H D; Landis W G; Raushel F M; Wild J R
Inactivation of organophosphorus nerve agents by the phosphotriesterase from Pseudomonas diminuta.
Archives of biochemistry and biophysics 1990;277(1):155-9.
1989: Raushel F M; Baldwin T O
Proposed mechanism for the bacterial bioluminescence reaction involving a dioxirane intermediate.
Biochemical and biophysical research communications 1989;164(3):1137-42.
1989: Dumas D P; Caldwell S R; Wild J R; Raushel F M
Purification and properties of the phosphotriesterase from Pseudomonas diminuta.
The Journal of biological chemistry 1989;264(33):19659-65.
1989: Donarski W J; Dumas D P; Heitmeyer D P; Lewis V E; Raushel F M
Structure-activity relationships in the hydrolysis of substrates by the phosphotriesterase from Pseudomonas diminuta.
Biochemistry 1989;28(11):4650-5.
1988: Kim S C; Singh A N; Raushel F M
Analysis of the galactosyltransferase reaction by positional isotope exchange and secondary deuterium isotope effects.
Archives of biochemistry and biophysics 1988;267(1):54-9.
1988: Kim S C; Raushel F M
Mechanism-based inactivation of rabbit muscle phosphoglucomutase by nojirimycin 6-phosphate.
Biochemistry 1988;27(19):7328-32.
1988: Kim S C; Singh A N; Raushel F M
The mechanism of glycogen synthetase as determined by deuterium isotope effects and positional isotope exchange experiments.
The Journal of biological chemistry 1988;263(21):10151-4.
1988: Lewis V E; Donarski W J; Wild J R; Raushel F M
Mechanism and stereochemical course at phosphorus of the reaction catalyzed by a bacterial phosphotriesterase.
Biochemistry 1988;27(5):1591-7.
1988: Kim S C; Raushel F M
The interaction of monofluorofumarate with adenylosuccinate lyase.
Journal of enzyme inhibition 1988;2(3):153-61.
1987: Hester L S; Raushel F M
Determination of the energetics of the UDP-glucose pyrophosphorylase reaction by positional isotope exchange inhibition.
Biochemistry 1987;26(20):6465-71.

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