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Mariella Ravazzola

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Sun Don Kim; Lelio Orci; Kanika Bajaj Pahuja; Mariella Ravazzola; Randy Schekman; Joonsik Yoon; Simeon Boyd; Susan Hammamoto; Jinoh Kim
The [corrected] SEC23-SEC31 [corrected] interface plays critical role for export of procollagen from the endoplasmic reticulum.
Pierre Cosson; Anna Marchetti; Mariella Ravazzola; Lelio Orci
Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study.
Grégory Lavieu; Lelio Orci; Lei Shi; Michael Geiling; Mariella Ravazzola; Felix Wieland; Pierre Cosson; James E Rothman
Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes.

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2012: Sun Don Kim; Lelio Orci; Kanika Bajaj Pahuja; Mariella Ravazzola; Randy Schekman; Joonsik Yoon; Simeon Boyd; Susan Hammamoto; Jinoh Kim
The [corrected] SEC23-SEC31 [corrected] interface plays critical role for export of procollagen from the endoplasmic reticulum.
The Journal of biological chemistry 2012;287(13):10134-44.
2012: Pierre Cosson; Anna Marchetti; Mariella Ravazzola; Lelio Orci
Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study.
PloS one 2012;7(9):e46293.
2010: Grégory Lavieu; Lelio Orci; Lei Shi; Michael Geiling; Mariella Ravazzola; Felix Wieland; Pierre Cosson; James E Rothman
Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):6876-81.
2009: Lelio Orci; Mariella Ravazzola; Marion Le Coadic; Wei-Wei Shen; Nicolas Demaurex; Pierre Cosson
From the Cover: STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(46):19358-62.
2008: May-Yun Wang; Paul Grayburn; Shuyuan Chen; Mariella Ravazzola; Lelio Orci; Roger H Unger
Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(16):6139-44.
2007: J Christopher Fromme; Mariella Ravazzola; Susan Hamamoto; Mohammed Al-Balwi; Wafaa Eyaid; Simeon Boyd; Pierre Cosson; Randy Schekman; Lelio Orci
The genetic basis of a craniofacial disease provides insight into COPII coat assembly.
Developmental cell 2007;13(5):623-34.
2007: Young Lee; Mariella Ravazzola; Byung-Hyun Park; Yuriy Bashmakov; Lelio Orci; Roger H Unger
Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin.
Diabetes 2007;56(9):2295-301.
2006: Byung-Hyun Park; May-Yun Wang; Young Lee; Xinxin Yu; Mariella Ravazzola; Lelio Orci; Roger H Unger
Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: implications for obesity treatment.
The Journal of biological chemistry 2006;281(52):40283-91.
2006: Simeon Boyd; J Christopher Fromme; Jalel BEN GHOZZIA; Samuel S Chong; Christopher Nauta; David J Hur; George Zhang; Susan Hamamoto; Randy Schekman; Mariella Ravazzola; Lelio Orci; Wafaa Eyaid
Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking.
Nature genetics 2006;38(10):1192-7.
2006: Elizabeth Karaskov; Cameron Scott; Liling Zhang; Tracy Teodoro; Mariella Ravazzola; Allen Volchuk
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis.
Endocrinology 2006;147(7):3398-407.
2005: May-Yun Wang; Lelio Orci; Mariella Ravazzola; Roger H Unger
Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):18011-6.
2005: Pierre Cosson; Mariella Ravazzola; Oleg Varlamov; Thomas H Söllner; Maurizio Di Liberto; Allen Volchuk; James E Rothman; Lelio Orci
Dynamic transport of SNARE proteins in the Golgi apparatus.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14647-52.
2005: Marcus C S Lee; Lelio Orci; Susan Hamamoto; Eugene Futai; Mariella Ravazzola; Randy Schekman
Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle.
Cell 2005;122(4):605-17.
2005: Jinoh Kim; Susan Hamamoto; Mariella Ravazzola; Lelio Orci; Randy Schekman
Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles.
The Journal of biological chemistry 2005;280(9):7758-68.
2004: Willy J Malaisse; Philippe Lebrun; Abdullah Sener; Gerrit H J Wolters; Mariella Ravazzola
Effects of thioacetamide on pancreatic islet B-cell function.
Endocrine 2004;24(1):83-91.
2004: Allen Volchuk; Mariella Ravazzola; Alain Perrelet; William S Eng; Maurizio Di Liberto; Oleg Varlamov; Masayoshi Fukasawa; Thomas Engel; Thomas H Söllner; James E Rothman; Lelio Orci
Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack.
Molecular biology of the cell 2004;15(4):1506-18.
2004: Lelio Orci; William S Cook; Mariella Ravazzola; May-Yun Wang; Byung-Hyun Park; Roberto Montesano; Roger H Unger
Rapid transformation of white adipocytes into fat-oxidizing machines.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2058-63.
2004: Oleg Varlamov; Allen Volchuk; Vahid Rahimian; Claudia A Doege; Fabienne Paumet; William S Eng; Nancy Arango; Francesco Parlati; Mariella Ravazzola; Lelio Orci; Thomas H Söllner; James E Rothman
i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion.
The Journal of cell biology 2004;164(1):79-88.
2003: Lelio Orci; Mariella Ravazzola; Gary J Mack; Charles Barlowe; Stefan Otte
Mammalian Erv46 localizes to the endoplasmic reticulum-Golgi intermediate compartment and to cis-Golgi cisternae.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4586-91.
2002: Xiaorong Zhu; Lelio Orci; Raymond Carroll; Christina Norrbom; Mariella Ravazzola; Donald F Steiner
Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10299-304.
2001: M Furuta; An Zhou; G Webb; Raymond Carroll; Mariella Ravazzola; Lelio Orci; Donald F Steiner
Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.
The Journal of biological chemistry 2001;276(29):27197-202.
2000: Y Shimoni; T Kurihara; Mariella Ravazzola; Mylene Amherdt; Lelio Orci; Randy Schekman
Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in Saccharomyces cerevisiae.
The Journal of cell biology 2000;151(5):973-84.
2000: Lelio Orci; Mylene Amherdt; Mariella Ravazzola; Alain Perrelet; James E Rothman
Exclusion of golgi residents from transport vesicles budding from Golgi cisternae in intact cells.
The Journal of cell biology 2000;150(6):1263-70.
2000: Lelio Orci; Mariella Ravazzola; Allen Volchuk; Thomas Engel; M Gmachl; Mylene Amherdt; Alain Perrelet; T H Sollner; James E Rothman
Anterograde flow of cargo across the golgi stack potentially mediated via bidirectional "percolating" COPI vesicles.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10400-5.
2000: Allen Volchuk; Mylene Amherdt; Mariella Ravazzola; Britta Brügger; Victor M Rivera; Tim Clackson; Alain Perrelet; Thomas H Söllner; James E Rothman; Lelio Orci
Megavesicles implicated in the rapid transport of intracisternal aggregates across the Golgi stack.
Cell 2000;102(3):335-48.
1999: M Higa; YT Zhou; Mariella Ravazzola; Danielle Baetens; Lelio Orci; Roger H Unger
Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11513-8.
1999: DU Gommel; Lelio Orci; E M Emig; Matthew J Hannah; Mariella Ravazzola; Walter Nickel; J Bernd Helms; Felix T Wieland; K Sohn
p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway.
FEBS letters 1999;447(2-3):179-85.
1999: M Bremser; Walter Nickel; M Schweikert; Mariella Ravazzola; Mylene Amherdt; C A Hughes; Thomas H Söllner; James E Rothman; Felix T Wieland
Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors.
Cell 1999;96(4):495-506.
1998: Walter Nickel; Jörg Malsam; Karin Gorgas; Mariella Ravazzola; N Jenne; J Bernd Helms; Felix T Wieland
Uptake by COPI-coated vesicles of both anterograde and retrograde cargo is inhibited by GTPgammaS in vitro.
Journal of cell science 1998;111 ( Pt 20)():3081-90.
1998: M Furuta; Raymond Carroll; S Martin; Hewson H Swift; Mariella Ravazzola; Lelio Orci; Donald F Steiner
Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.
The Journal of biological chemistry 1998;273(6):3431-7.
1997: Yogesh C Patel; Aristea S Galanopoulou; S N Rabbani; J L Liu; Mariella Ravazzola; Mylene Amherdt
Somatostatin-14, somatostatin-28, and prosomatostatin[1-10] are independently and efficiently processed from prosomatostatin in the constitutive secretory pathway in islet somatostatin tumor cells (1027B2).
Molecular and cellular endocrinology 1997;131(2):183-94.
1997: Lelio Orci; Mark Stamnes; Mariella Ravazzola; Mylene Amherdt; Alain Perrelet; Thomas H Söllner; James E Rothman
Bidirectional transport by distinct populations of COPI-coated vesicles.
Cell 1997;90(2):335-49.
1997: M Furuta; H Yano; An Zhou; Yves Rouillé; Jens J Holst; Raymond Carroll; Mariella Ravazzola; Lelio Orci; H Furuta; Donald F Steiner
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6646-51.
1997: I Paek; Lelio Orci; Mariella Ravazzola; Hediye Erdjument-Bromage; Mylene Amherdt; Paul Tempst; Thomas H Söllner; James E Rothman
ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi.
The Journal of cell biology 1997;137(5):1017-28.
1996: K Sohn; L Orci; Mariella Ravazzola; Mylene Amherdt; M Bremser; F Lottspeich; Klaus Fiedler; J Bernd Helms; Felix T Wieland
A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding.
The Journal of cell biology 1996;135(5):1239-48.
1996: Jean-Pierre Paccaud; Walter Reith; Jean-Louis Carpentier; Mariella Ravazzola; Mylene Amherdt; Randy Schekman; L Orci
Cloning and functional characterization of mammalian homologues of the COPII component Sec23.
Molecular biology of the cell 1996;7(10):1535-46.
1996: D Faulstich; S Auerbach; L Orci; Mariella Ravazzola; S Wegchingel; F Lottspeich; G Stenbeck; Christoph Harter; Felix T Wieland; H Tschochner
Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex.
The Journal of cell biology 1996;135(1):53-61.
1996: Romano Regazzi; Mariella Ravazzola; M Iezzi; Jochen Lang; A Zahraoui; Elisabeth Andereggen; P Morel; Y Takai; C B Wollheim
Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells.
Journal of cell science 1996;109 ( Pt 9)():2265-73.
1996: M Nagahama; L Orci; Mariella Ravazzola; Mylene Amherdt; Lynne Lacomis; Paul Tempst; James E Rothman; Thomas H Söllner
A v-SNARE implicated in intra-Golgi transport.
The Journal of cell biology 1996;133(3):507-16.
1995: S Y Bednarek; Mariella Ravazzola; M Hosobuchi; Mylene Amherdt; Alain Perrelet; Randy Schekman; L Orci
COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast.
Cell 1995;83(7):1183-96.
1995: B Gerich; L Orci; H Tschochner; F Lottspeich; Mariella Ravazzola; M Amherdt; Felix T Wieland; Christoph Harter
Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3229-33.
1994: L Orci; Alain Perrelet; Mariella Ravazzola; Mylene Amherdt; James E Rothman; Randy Schekman
Coatomer-rich endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11924-8.
1994: L Orci; Philippe A Halban; Alain Perrelet; Mylene Amherdt; Mariella Ravazzola; R G Anderson
pH-independent and -dependent cleavage of proinsulin in the same secretory vesicle.
The Journal of cell biology 1994;126(5):1149-56.
1994: C Barlowe; L Orci; T Yeung; M Hosobuchi; Susan Hamamoto; N Salama; M F Rexach; Mariella Ravazzola; Mylene Amherdt; Randy Schekman
COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum.
Cell 1994;77(6):895-907.
1994: O Kuge; C Dascher; L Orci; T Rowe; Mylene Amherdt; Helen Plutner; Mariella Ravazzola; G Tanigawa; James E Rothman; William E Balch
Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments.
The Journal of cell biology 1994;125(1):51-65.
1994: S Hara-Kuge; O Kuge; L Orci; Mylene Amherdt; Mariella Ravazzola; Felix T Wieland; James E Rothman
En bloc incorporation of coatomer subunits during the assembly of COP-coated vesicles.
The Journal of cell biology 1994;124(6):883-92.
1993: J Ostermann; L Orci; K Tani; Mylene Amherdt; Mariella Ravazzola; Z Elazar; James E Rothman
Stepwise assembly of functionally active transport vesicles.
Cell 1993;75(5):1015-25.
1993: O Kuge; S Hara-Kuge; L Orci; Mariella Ravazzola; Mylene Amherdt; G Tanigawa; Felix T Wieland; James E Rothman
zeta-COP, a subunit of coatomer, is required for COP-coated vesicle assembly.
The Journal of cell biology 1993;123(6 Pt 2):1727-34.
1993: G Tanigawa; L Orci; Mylene Amherdt; Mariella Ravazzola; J Bernd Helms; James E Rothman
Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles.
The Journal of cell biology 1993;123(6 Pt 1):1365-71.
1993: L Orci; Alain Perrelet; Mariella Ravazzola; F T Wieland; Randy Schekman; James E Rothman
"BFA bodies": a subcompartment of the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11089-93.
1993: L Orci; D J Palmer; Mariella Ravazzola; Alain Perrelet; Mylene Amherdt; James E Rothman
Budding from Golgi membranes requires the coatomer complex of non-clathrin coat proteins.
Nature 1993;362(6421):648-52.
1992: Romano Regazzi; L Vallar; S Ullrich; Mariella Ravazzola; A Kikuchi; Y Takai; C B Wollheim
Characterization of small-molecular-mass guanine-nucleotide-binding regulatory proteins in insulin-secreting cells and PC12 cells.
European journal of biochemistry / FEBS 1992;208(3):729-37.
1991: L Orci; Mariella Ravazzola; Paolo Meda; C Holcomb; Hsiao-Ping H Moore; L Hicke; Randy Schekman
Mammalian Sec23p homologue is restricted to the endoplasmic reticulum transitional cytoplasm.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8611-5.
1991: D Quinn; L Orci; Mariella Ravazzola; Hsiao-Ping H Moore
Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers.
The Journal of cell biology 1991;113(5):987-96.
1990: L Orci; Mariella Ravazzola; D Baetens; L Inman; Mylene Amherdt; R G Peterson; Christopher B Newgard; J H Johnson; Roger H Unger
Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9953-7.
1990: L Orci; Roger H Unger; Mariella Ravazzola; A Ogawa; I Komiya; D Baetens; Harvey Lodish; B Thorens
Reduced beta-cell glucose transporter in new onset diabetic BB rats.
The Journal of clinical investigation 1990;86(5):1615-22.
1987: L Orci; Mariella Ravazzola; Mylene Amherdt; Alain Perrelet; S K Powell; D L Quinn; Hsiao-Ping H Moore
The trans-most cisternae of the Golgi complex: a compartment for sorting of secretory and plasma membrane proteins.
Cell 1987;51(6):1039-51.
1984: L Orci; P Halban; Mylene Amherdt; Mariella Ravazzola; J D Vassalli; Alain Perrelet
Nonconverted, amino acid analog-modified proinsulin stays in a Golgi-derived clathrin-coated membrane compartment.
The Journal of cell biology 1984;99(6):2187-92.
1984: L Orci; P Halban; Mylene Amherdt; Mariella Ravazzola; J D Vassalli; Alain Perrelet
A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin.
Cell 1984;39(1):39-47.
1984: L Orci; Mariella Ravazzola; Mylene Amherdt; C Yanaihara; N Yanaihara; P Halban; A E Renold; Alain Perrelet
Insulin, not C-peptide (proinsulin), is present in crinophagic bodies of the pancreatic B-cell.
The Journal of cell biology 1984;98(1):222-8.