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Vasulinga Ravikumar

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Shabbir Ali S Taj; S Narayanan; S Suman Meenakshi; Yogesh S Sanghvi; Bruce S Ross; Vasulinga T Ravikumar
Process research on the preparation of DMT protected 2'-O-methoxyethylguanosine for oligonucleotide synthesis in therapeutic applications.
Jyotirmoy Maity; Gaurav Shakya; Sunil K Singh; Vasulinga T Ravikumar; Virinder S Parmar; Ashok K Prasad
Efficient and selective enzymatic acylation reaction: separation of furanosyl and pyranosyl nucleosides.
Bruce S Ross; Robert H Springer; Vasulinga T Ravikumar
An efficient and scalable synthesis of 2,6-diaminopurine riboside.

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All Publications

2008: Shabbir Ali S Taj; S Narayanan; S Suman Meenakshi; Yogesh S Sanghvi; Bruce S Ross; Vasulinga T Ravikumar
Process research on the preparation of DMT protected 2'-O-methoxyethylguanosine for oligonucleotide synthesis in therapeutic applications.
Nucleosides, nucleotides & nucleic acids 2008;27(9):1024-33.
2008: Jyotirmoy Maity; Gaurav Shakya; Sunil K Singh; Vasulinga T Ravikumar; Virinder S Parmar; Ashok K Prasad
Efficient and selective enzymatic acylation reaction: separation of furanosyl and pyranosyl nucleosides.
The Journal of organic chemistry 2008;73(14):5629-32.
2008: Bruce S Ross; Robert H Springer; Vasulinga T Ravikumar
An efficient and scalable synthesis of 2,6-diaminopurine riboside.
Nucleosides, nucleotides & nucleic acids 2008;27(1):67-9.
2007: Zhiwei Wang; Phil Olsen; Vasulinga T Ravikumar
A novel universal linker for efficient synthesis of phosphorothioate oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2007;26(3):259-69.
2007: R Krishna Kumar; Phil Olsen; Vasulinga T Ravikumar
An alternative advantageous protocol for efficient synthesis of phosphorothioate oligonucleotides utilizing phenylacetyl disulfide (PADS).
Nucleosides, nucleotides & nucleic acids 2007;26(2):181-8.
2006: Zhiwei Wang; Andrew Siwkowski; Walt F Lima; Phil Olsen; Vasulinga T Ravikumar
Antisense oligonucleotides: efficient synthesis of 2'-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator?
Bioorganic & medicinal chemistry 2006;14(14):5049-60.
2006: Vasulinga T Ravikumar; Mark Andrade; Recaldo L Carty; Amy Dan; Steve Barone
Development of siRNA for therapeutics: efficient synthesis of phosphorothioate RNA utilizing phenylacetyl disulfide (PADS).
Bioorganic & medicinal chemistry letters 2006;16(9):2513-7.
2006: Christine Kurata; Kym Bradley; Hans Gaus; Nhuy Luu; Isaiah Cedillo; Vasulinga T Ravikumar; Kent Van Sooy; James V McArdle; Daniel C Capaldi
Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides.
Bioorganic & medicinal chemistry letters 2006;16(3):607-14.
2006: Bruce S Ross; Mingming Han; Vasulinga T Ravikumar
Efficient large-scale synthesis of 5'-O-dimethoxytrityl-N4-benzoyl-5-methyl-2'-deoxycytidine.
Nucleosides, nucleotides & nucleic acids 2006;25(7):765-70.
2005: R Krishna Kumar; Vasulinga T Ravikumar
4,4'-Dimethoxytrityl group derived from secondary alcohols: are they removed slowly under acidic conditions?
Bioorganic & medicinal chemistry letters 2005;15(14):3426-9.
2005: Ashok K Prasad; Vineet Kumar; Shashwat Malhotra; Vasulinga T Ravikumar; Yogesh S Sanghvi; Virinder S Parmar
'Green' methodology for efficient and selective benzoylation of nucleosides using benzoyl cyanide in an ionic liquid.
Bioorganic & medicinal chemistry 2005;13(14):4467-72.
2005: Ashok K Prasad; Vineet Kumar; Jyotirmoy Maity; Yogesh S Sanghvi; Vasulinga T Ravikumar; Virinder S Parmar
Mild, efficient, selective and "green" benzoylation of nucleosides using benzoyl cyanide in ionic liquid.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):747-51.
2004: Daniel C Capaldi; Hans Gaus; Recaldo L Carty; Max N Moore; Brett Turney; Stella D Decottignies; James V McArdle; Anthony N Scozzari; Vasulinga T Ravikumar; Achim H Krotz
Formation of 4,4'-dimethoxytrityl-C-phosphonate oligonucleotides.
Bioorganic & medicinal chemistry letters 2004;14(18):4683-90.
2004: Vasulinga T Ravikumar; Walt F Lima; Kent Van Sooy; Brett Turney
Biologically active antisense phosphorothioate oligodeoxyribonucleotides: synthesis, characterization, and studies of 3'-terminal phosphorothioate monoester analogues.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):149-60.
2003: Walt F Lima; Hongjiang Wu; Josh G Nichols; Thazha P Prakash; Vasulinga T Ravikumar; Stanley T Crooke
Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.
The Journal of biological chemistry 2003;278(50):49860-7.
2003: Vasulinga T Ravikumar; Daniel C Capaldi; Walt F Lima; Elena Lesnik; Brett Turney; Douglas L Cole
Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide synthesis.
Bioorganic & medicinal chemistry 2003;11(21):4673-9.
2003: Vasulinga T Ravikumar; Douglas L Cole
Diastereomeric process control in the synthesis of 2'-O-(2-methoxyethyl) oligoribonucleotide phosphorothioates as antisense drugs.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1639-45.
2003: Vasulinga T Ravikumar; R Krishna Kumar; Daniel C Capaldi; Douglas L Cole
Synthesis of high quality phosphorothioate oligonucleotides as antisense drugs. Use of I-linker in the elimination of 3'-terminal phosphorothioate monoesters.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1421-5.
2003: Vasulinga T Ravikumar; Douglas L Cole
Understanding high diastereomeric discrimination in formation of oligoribonucleotide phosphorothioate linkages: the first study of pKa-dependent activation in solid-supported coupling of 2'-O-substituted ribonucleoside phosphoramidites.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1415-9.
2003: Zacharia S Cheruvallath; R Krishna Kumar; Claus Rentel; Douglas L Cole; Vasulinga T Ravikumar
Solid phase synthesis of phosphorothioate oligonucleotides utilizing diethyldithiocarbonate disulfide (DDD) as an efficient sulfur transfer reagent.
Nucleosides, nucleotides & nucleic acids 2003;22(4):461-8.
2003: R Krishna Kumar; Douglas L Cole; Vasulinga T Ravikumar
2-Methyl-5-tert-butylthiophenol--an odorless deprotecting reagent useful in synthesis of oligonucleotides and their analogs.
Nucleosides, nucleotides & nucleic acids 2003;22(4):453-60.
2003: Achim H Krotz; Douglas L Cole; Vasulinga T Ravikumar
Synthesis of antisense oligonucleotides with minimum depurination.
Nucleosides, nucleotides & nucleic acids 2003;22(2):129-34.
2003: Zacharia S Cheruvallath; Douglas L Cole; Vasulinga T Ravikumar
A novel solid support for synthesis of oligonucleotide 3'-phosphorothioate monoesters.
Bioorganic & medicinal chemistry letters 2003;13(2):281-4.
2001: Achim H Krotz; Hans Gaus; Vasulinga T Ravikumar; Douglas L Cole
Preparation of oligonucleotides without aldehyde abasic sites.
Bioorganic & medicinal chemistry letters 2001;11(14):1863-7.
2000: Daniel C Capaldi; Douglas L Cole; Vasulinga T Ravikumar
Highly efficient solid phase synthesis of oligonucleotide analogs containing phosphorodithioate linkages.
Nucleic acids research 2000;28(9):E40.
2000: Zacharia S Cheruvallath; Henri Sasmor; Douglas L Cole; Vasulinga T Ravikumar
Influence of diastereomeric ratios of deoxyribonucleoside phosphoramidites on the synthesis of phosphorothioate oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2000;19(3):533-43.
1999: Achim H Krotz; Douglas L Cole; Vasulinga T Ravikumar
Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents.
Bioorganic & medicinal chemistry 1999;7(3):435-9.
1999: Brett Turney; Zacharia S Cheruvallath; M Andrade; Douglas L Cole; Vasulinga T Ravikumar
Stability of phosphorothioate oligonucleotides in aqueous ammonia in presence of stainless steel.
Nucleosides & nucleotides 1999;18(1):89-93.
1994: Vasulinga T Ravikumar; D L Cole
2-Diphenylmethylsilylethyl (DPSE): a versatile protecting group for oligodeoxyribonucleotide synthesis.
Gene 1994;149(1):157-61.