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Richard Reba

Research Profile

Chemicals & Drugs

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TOP 3
Julie Dyall; Louis Huzella; Peter B Jahrling; Gerald Jennings; Reed F Johnson; Daniel J Mollura; Joseph E Blaney; Russ Byrum; Dar-Yeong Chen; Dan R Ragland; Richard C Reba; Jason Paragas
Evaluation of monkeypox disease progression by molecular imaging.
William Eckelman; Richard C Reba; Gary J Kelloff
Targeted imaging: an important biomarker for understanding disease progression in the era of personalized medicine.
Ismet Sarikaya; Ali Sarikaya; Richard C Reba
Gamma probes and their use in tumor detection in colorectal cancer.

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All Publications

2011: Julie Dyall; Louis Huzella; Peter B Jahrling; Gerald Jennings; Reed F Johnson; Daniel J Mollura; Joseph E Blaney; Russ Byrum; Dar-Yeong Chen; Dan R Ragland; Richard C Reba; Jason Paragas
Evaluation of monkeypox disease progression by molecular imaging.
The Journal of infectious diseases 2011;204(12):1902-11.
2008: William Eckelman; Richard C Reba; Gary J Kelloff
Targeted imaging: an important biomarker for understanding disease progression in the era of personalized medicine.
Drug discovery today 2008;13(17-18):748-59.
2008: Ismet Sarikaya; Ali Sarikaya; Richard C Reba
Gamma probes and their use in tumor detection in colorectal cancer.
International seminars in surgical oncology : ISSO 2008;5():25.
2007: Michael L Szmodis; Richard C Reba; David Earl-Graef
Positron emission tomography in the diagnosis and management of giant cell arteritis.
Headache 2007;47(8):1216-9.
2005: John C Roeske; Anthony E Lujan; Richard C Reba; Bill C Penney; S Diane Yamada; Arno J Mundt
Incorporation of SPECT bone marrow imaging into intensity modulated whole-pelvic radiation therapy treatment planning for gynecologic malignancies.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2005;77(1):11-7.
2003: Thomas G Stinchcomb; Christina Soyland; Sindre P Hassfjell; John Westman; Steven J Wang; Jenny L Whitlock; Richard C Reba; Jacob Rotmensch; John C Roeske
Binary methods for the microdosimetric analysis of cell survival data from alpha-particle irradiation.
Cancer biotherapy & radiopharmaceuticals 2003;18(3):481-7.
2003: Steven J Wang; Jenny L Whitlock; Christina Soyland; Sindre P Hassfjell; Thomas G Stinchcomb; Jacob Rotmensch; Richard C Reba; John C Roeske
Characterization of an alpha-particle irradiator for individual cell dosimetry measurements.
Cancer biotherapy & radiopharmaceuticals 2003;18(3):437-44.
2003: John C Roeske; Christina Soyland; Steven J Wang; Thomas G Stinchcomb; Sindre P Hassfjell; Jenny L Whitlock; Richard C Reba; Jacob Rotmensch
Image processing tools for alpha-particle track-etch dosimetry.
Cancer biotherapy & radiopharmaceuticals 2003;18(3):425-30.
2002: Martin J Lipton; Jan Bogaert; Lawrence M Boxt; Richard C Reba
Imaging of ischemic heart disease.
European radiology 2002;12(5):1061-80.
2000: VI Cohen; B Jin; R C McRee; SF Boulay; E I Cohen; VK Sood; BR Zeeberg; Richard C Reba
In vitro and in vivo m2 muscarinic subtype selectivity of some dibenzodiazepinones and pyridobenzodiazepinones.
Brain research 2000;861(2):305-15.
1998: R Gunderman; Jeffrey A Leef; Martin J Lipton; Richard C Reba
Diagnostic imaging and the outcome of acute lower gastrointestinal bleeding.
Academic radiology 1998;5 Suppl 2():S303-5.
1998: VI Cohen; BR Zeeberg; SF Boulay; VK Sood; MR Rayeq; R A Danesh; DW McPherson; Richard C Reba
In vivo competition studies of Z-(-,-)-[125I]IQNP against 3-quinuclidinyl 2-(5-bromothienyl)-2-thienylglycolate (BrQNT) demonstrating in vivo m2 muscarinic subtype selectivity for BrQNT.
Journal of molecular neuroscience : MN 1998;11(1):1-9.
1998: R Gunderman; Jeffrey A Leef; K Ong; Richard C Reba; Charles E Metz
Scintigraphic screening prior to visceral arteriography in acute lower gastrointestinal bleeding.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(6):1081-3.
1997: Jacob Rotmensch; Jenny L Whitlock; J L Schwartz; J J Hines; Richard C Reba; P V Harper
In vitro and in vivo studies on the development of the alpha-emitting radionuclide bismuth 212 for intraperitoneal use against microscopic ovarian carcinoma.
American journal of obstetrics and gynecology 1997;176(4):833-40; discussion 840-1.
1997: BR Zeeberg; SF Boulay; Miriam Gitler; VK Sood; Richard C Reba
Correction of the stereochemical assignment of the benzilic acid center in (R)-(-)-3-quinuclidinyl (S)-(+)-4-iodobenzilate [(R,S)-4-IQNB].
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1997;48(4):463-7.
1997: OH Kapp; J Siemion; William Eckelman; VI Cohen; Richard C Reba
Molecular modeling of the interaction of diagnostic radiopharmaceuticals with receptor proteins: m2 antagonist binding to the muscarinic m2 subtype receptor.
Receptors & signal transduction 1997;7(3):177-201.
1997: VK Sood; K S Lee; SF Boulay; MR Rayeq; R C McRee; E I Cohen; BR Zeeberg; X S He; Daniel R Weinberger; K Rice; Richard C Reba
In vivo autoradiography of radioiodinated (R)-3-quinuclidinyl (S)-4-iodobenzilate [(R, S)-IQNB] and (R)-3-quinuclidinyl (R)-4-iodobenzilate [(R,R)-IQNB]. Comparison of the radiolabelled products of a novel tributylstannyl precursor with those of the established triazene and exchange methods.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1997;48(1):27-35.
1996: H Luo; A Hasan; VK Sood; R C McRee; BR Zeeberg; Richard C Reba; DW McPherson; Furn F Knapp
Evaluation of 1-azabicyclo[2.2.2]oct-3-yl alpha-fluoroalkyl-alpha-hydroxy-alpha-phenylacetates as potential ligands for the study of muscarinic receptor density by positron emission tomography.
Nuclear medicine and biology 1996;23(3):267-76.
1996: SF Boulay; R C McRee; V I Cohen; VK Sood; BR Zeeberg; Richard C Reba
Specific binding component of the "inactive" stereoisomer (S,S)-[125I] IQNB to rat brain muscarinic receptors in vivo.
Nuclear medicine and biology 1996;23(3):211-9.
1996: SF Boulay; VK Sood; M R Rayeq; V I Cohen; BR Zeeberg; Richard C Reba
Autoradiographic evidence that 3-quinuclidinyl-4-fluorobenzilate (FQNB) displays in vivo selectivity for the m2 subtype.
NeuroImage 1996;3(1):35-9.
1995: DW McPherson; C R Lambert; K Jahn; VK Sood; R C McRee; BR Zeeberg; Richard C Reba; Furn F Knapp
Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor.
Journal of medicinal chemistry 1995;38(20):3908-17.
1995: SF Boulay; VK Sood; M R Rayeq; R C McRee; E I Cohen; V I Cohen; BR Zeeberg; Richard C Reba
Autoradiographic evidence that quinuclidinyl 4-(bromophenyl)-2-thienylglycolate (QBPTG) displays in vivo selectivity for the muscarinic m2 subtype.
NeuroImage 1995;2(3):209-13.
1995: M S Gitler; SF Boulay; VK Sood; DW McPherson; F F Knap; BR Zeeberg; Richard C Reba
Characterization of in vivo brain muscarinic acetylcholine receptor subtype selectivity by competition studies against (R,S)-[125I]IQNB.
Brain research 1995;687(1-2):71-8.
1995: R C McRee; SF Boulay; VK Sood; E I Cohen; V I Cohen; Miriam Gitler; BR Zeeberg; Raymond E Gibson; Richard C Reba
Autoradiographic evidence that QNB displays in vivo selectivity for the m2 subtype.
NeuroImage 1995;2(1):55-62.
1995: SF Boulay; M S Gitler; VK Sood; V I Cohen; BR Zeeberg; Richard C Reba
Comparison of the in vivo rat brain regional pharmacokinetics of [3H]QNB, (R,S)-[125I]-4IQNB, and (R,R)-[125I]-4IQNB binding to the muscarinic acetylcholine receptor in relationship to the regional subtype composition.
Receptor 1995;5(4):207-18.
1994: J Baumgold; R L Pryzbyc; Richard C Reba
3-alpha-Chlorimperialine: an M2-selective muscarinic receptor antagonist that penetrates into brain.
European journal of pharmacology 1994;251(2-3):315-7.
1994: Raymond E Gibson; T A Schneidau; M Gitler; BR Zeeberg; Richard C Reba
Muscarinic receptor selectivities of 3-Quinuclidinyl 8-xanthenecarboxylate (QNX) in rat brain.
Life sciences 1994;54(23):1757-65.
1994: Miriam Gitler; R De la Cruz; BR Zeeberg; Richard C Reba
[3H]QNB displays in vivo selectivity for the m2 subtype.
Life sciences 1994;55(19):1493-508.
1993: CS John; Wayne D Bowen; T Saga; S Kinuya; BJ Vilner; J Baumgold; Chang H Paik; Richard C Reba; R D Neumann; V M Varma
A malignant melanoma imaging agent: synthesis, characterization, in vitro binding and biodistribution of iodine-125-(2-piperidinylaminoethyl)4-iodobenzamide.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(12):2169-75.
1993: V I Cohen; J Baumgold; B Jin; R De La Cruz; W J Rzeszotarski; Richard C Reba
Synthesis and structure-activity relationship of some 5-[[[(dialkylamino)alkyl]-1-piperidinyl]acetyl]-10,11-dihydro-5H- benzo[b,e][1,4]diazepin-11-ones as M2-selective antimuscarinics.
Journal of medicinal chemistry 1993;36(1):162-5.
1993: CS John; T Saga; S Kinuya; Nhat Le; J M Jeong; Chang H Paik; Richard C Reba; V M Varma; J G McAfee
An improved synthesis of [125I]N-(diethylaminoethyl)-4-iodobenzamide: a potential ligand for imaging malignant melanoma.
Nuclear medicine and biology 1993;20(1):75-9.
1993: M S Gitler; V I Cohen; R De la Cruz; SF Boulay; B Jin; BR Zeeberg; Richard C Reba
A novel muscarinic receptor ligand which penetrates the blood brain barrier and displays in vivo selectivity for the m2 subtype.
Life sciences 1993;53(23):1743-51.
1992: N Safi; R R Kantor; B Atkinson; C Moratz; A R Wilt; S Pancake; Richard C Reba; B J Mathieson; A Desgrez
Two antigens detected on human ocular melanomas with the mouse monoclonal antibodies 2/10SN and 10/12SN.
International journal of cancer. Journal international du cancer 1992;51(5):718-26.
1992: Chang H Paik; V K Sood; Nhat Le; L Cioloca; Jorge Carrasquillo; James C Reynolds; Ronald D Neumann; Richard C Reba
Radiolabeled products in rat liver and serum after administration of antibody-amide-DTPA-indium-111.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(5):517-22.
1992: J Baumgold; P Y Ling; Richard C Reba
Use of ex vivo binding to measure the brain concentrations of putative radioligands.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(5):513-6.
1992: Miriam Gitler; Richard C Reba; V I Cohen; W J Rzeszotarski; B Jin; J Baumgold
A novel m2-selective muscarinic antagonist: binding characteristics and autoradiographic distribution in rat brain.
Brain research 1992;582(2):253-60.
1992: H J Kim; BR Zeeberg; Richard C Reba
Compensation for three-dimensional detector response, attenuation and scatter in SPECT grey matter imaging using an iterative reconstruction algorithm which incorporates a high-resolution anatomical image.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(6):1225-34.
1992: V I Cohen; Raymond E Gibson; L H Fan; R de la Cruz; M S Gitler; E Hariman; Richard C Reba
Synthesis and receptor affinities of new 3-quinuclidinyl alpha-heteroaryl-alpha-aryl-alpha-hydroxyacetates.
Journal of pharmaceutical sciences 1992;81(4):326-9.
1992: CS John; E O Schlemper; P Hosain; Chang H Paik; Richard C Reba
Synthesis, characterization and biodistribution of a new hexadentate aminethiol ligand labeled with Tc-99m.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(3):269-74.
1992: Raymond E Gibson; Terry W Moody; T A Schneidau; E M Jagoda; Richard C Reba
The in vitro dissociation kinetics of (R,R)-[125I]4IQNB is reflected in the in vivo washout of the radioligand from rat brain.
Life sciences 1992;50(9):629-37.
1992: BR Zeeberg; H J Kim; Richard C Reba
Pharmacokinetic simulations of SPECT quantitation of the M2 muscarinic neuroreceptor subtype in disease states using radioiodinated (R,R)-4IQNB.
Life sciences 1992;51(9):661-70.
1991: V I Cohen; Raymond E Gibson; L H Fan; R De La Cruz; Miriam Gitler; E Hariman; Richard C Reba
Synthesis and muscarinic cholinergic receptor affinities of 3-quinuclidinyl alpha-(alkoxyalkyl)-alpha-aryl-alpha-hydroxyacetates.
Journal of medicinal chemistry 1991;34(10):2989-93.
1991: H J Kim; BR Zeeberg; F H Fahey; A N Bice; E J Hoffman; Richard C Reba
Three-dimensional SPECT simulations of a complex three-dimensional mathematical brain model and measurements of the three-dimensional physical brain phantom.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(10):1923-30.
1991: BR Zeeberg; M S Gitler; J Baumgold; R A de la Cruz; Richard C Reba
Binding of radioiodinated SPECT ligands to transfected cell membranes expressing single muscarinic receptor subtypes.
Biochemical and biophysical research communications 1991;179(2):768-75.
1991: Raymond E Gibson; BR Zeeberg; J M Melograna; T F Wang; J Ruch; A Braun; Richard C Reba
In vivo dissociation kinetics of [3H]quinuclidinyl benzilate: relationship to muscarinic receptor concentration and in vitro kinetics.
Brain research 1991;553(1):110-6.
1991: H J Kim; BR Zeeberg; M H Loew; Richard C Reba
Three-dimensional simulations of multidetector point-focusing SPECT imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(2):333-8.
1991: J Baumgold; V I Cohen; R Paek; Richard C Reba
Muscarinic receptor subtype selectivity of novel heterocyclic QNB analogues.
Life sciences 1991;48(24):2325-9.
1990: M S Gitler; BR Zeeberg; C John; Richard C Reba
Specific in vivo binding of [125I]-iodomelatonin to melatonin receptors in rat brain.
Neuropharmacology 1990;29(6):603-8.
1990: K Yokoyama; James C Reynolds; Chang H Paik; V K Sood; P J Maloney; Steven M Larson; Richard C Reba
Immunoreactivity affects the biodistribution and tumor targeting of radiolabeled anti-P97 Fab fragment.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(2):202-10.
1989: R S Siegel; J L Rae; N L Ryan; C Edwards; W P Fortune; R J Lewis; Richard C Reba
The use of indium-111 labeled platelet scanning for the detection of asymptomatic deep venous thrombosis in a high risk population.
Orthopedics 1989;12(11):1439-43.
1989: Chang H Paik; K Yokoyama; James C Reynolds; S M Quadri; C Y Min; S Y Shin; P J Maloney; Steven M Larson; Richard C Reba
Reduction of background activities by introduction of a diester linkage between antibody and a chelate in radioimmunodetection of tumor.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1989;30(10):1693-701.
1989: V I Cohen; W J Rzeszotarski; Raymond E Gibson; L H Fan; Richard C Reba
Preparation and properties of (R)-(-)-1-azabicyclo[2.2.2]oct-3-yl- (R)-(+)-alpha-hydroxy-alpha-(4-[125I]iodophenyl)-alpha-phenyl acetate and (R)-(-)-1-azabicyclo[2.2.2]oct-3-yl-(S)-(-)-alpha-hydroxy-alpha- (4-[125I]iodophenyl)-alpha-phenyl acetate as potential radiopharmaceuticals.
Journal of pharmaceutical sciences 1989;78(10):833-6.
1989: Raymond E Gibson; T A Schneidau; V I Cohen; VK Sood; J Ruch; J Melograna; William Eckelman; Richard C Reba
In vitro and in vivo characteristics of [iodine-125] 3-(R)-quinuclidinyl (S)-4-iodobenzilate.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1989;30(6):1079-87.
1989: R S Siegel; J L Rae; S Barth; R E Coleman; Richard C Reba; Roger Kurlander; W F Rosse
Platelet survival and turnover: important factors in predicting response to splenectomy in immune thrombocytopenic purpura.
American journal of hematology 1989;30(4):206-12.
1989: Chang H Paik; S M Quadri; Richard C Reba
Interposition of different chemical linkages between antibody and 111In-DTPA to accelerate clearance from non-target organs and blood.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1989;16(5):475-81.
1988: E V Kotlyarov; V S Mattay; Richard C Reba
Gallbladder visualization during technetium-99m RBC blood pool imaging. Case report and literature review.
Clinical nuclear medicine 1988;13(7):515-6.
1987: V I Cohen; Raymond E Gibson; Richard C Reba
Synthesis and structure-activity relationships of new muscarinic antagonists.
Journal of pharmaceutical sciences 1987;76(10):848-50.
1985: William Eckelman; R Eng; W J Rzeszotarski; Raymond E Gibson; B Francis; Richard C Reba
Use of 3-quinuclidinyl 4-iodobenzilate as a receptor binding radiotracer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1985;26(6):637-42.
1985: Raymond E Gibson; William Eckelman; Richard C Reba; E M Jagoda; W J Rzeszotarski; M Grissom; J Conklin; R Eng
Receptor-selective localization in pancreas.
International journal of nuclear medicine and biology 1985;12(1):29-32.
1984: I Nakatsuka; N L Ferreira; William Eckelman; B E Francis; W J Rzeszotarski; Raymond E Gibson; E M Jagoda; Richard C Reba
Synthesis and evaluation of (17 alpha,20E)-21-[125I]iodo-19-norpregna-1,3,5(10),20-tetraene-3,17 -diol and (17 alpha,20E)-21-[125I]iodo-11 beta-methoxy-19-norpregna-1,3,5(10),20-tetraene-3,17-diol (17 alpha-(iodovinyl)estradiol derivatives) as high specific activity potential radiopharmaceuticals.
Journal of medicinal chemistry 1984;27(10):1287-91.
1984: Raymond E Gibson; W J Rzeszotarski; E M Jagoda; B E Francis; Richard C Reba; William Eckelman
[125I] 3-quinuclidinyl 4-iodobenzilate: a high affinity, high specific activity radioligand for the M1 and M2-acetylcholine receptors.
Life sciences 1984;34(23):2287-96.
1984: E M Jagoda; Raymond E Gibson; H Goodgold; N Ferreira; B E Francis; Richard C Reba; W J Rzeszotarski; W C Eckelman
[I-125] 17 alpha-Iodovinyl 11 beta-methoxyestradiol: in vivo and in vitro properties of a high-affinity estrogen-receptor radiopharmaceutical.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1984;25(4):472-7.
1984: W C Eckelman; M Grissom; J Conklin; W J Rzeszotarski; Raymond E Gibson; B E Francis; E M Jagoda; R Eng; Richard C Reba
In vivo competition studies with analogues of 3-quinuclidinyl benzilate.
Journal of pharmaceutical sciences 1984;73(4):529-34.
1984: Raymond E Gibson; D J Weckstein; E M Jagoda; W J Rzeszotarski; Richard C Reba; W C Eckelman
The characteristics of I-125 4-IQNB and H-3 QNB in vivo and in vitro.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1984;25(2):214-22.
1984: W J Rzeszotarski; W C Eckelman; B E Francis; D A Simms; Raymond E Gibson; E M Jagoda; M P Grissom; R R Eng; J J Conklin; Richard C Reba
Synthesis and evaluation of radioiodinated derivatives of 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(4-iodophenyl)-alpha- phenylacetate as potential radiopharmaceuticals.
Journal of medicinal chemistry 1984;27(2):156-60.
1984: W C Eckelman; Richard C Reba; W J Rzeszotarski; Raymond E Gibson; T Hill; B L Holman; T Budinger; J J Conklin; R Eng; M P Grissom
External imaging of cerebral muscarinic acetylcholine receptors.
Science (New York, N.Y.) 1984;223(4633):291-3.
1984: W C Eckelman; W A Alter; M P Grissom; F Vieras; J Phillips; R Eng; Raymond E Gibson; Richard C Reba
Comparison of myocardial uptake and distribution of thallium-201 and two prototype receptor-binding radiopharmaceuticals in the normal and ischemic canine heart.
International journal of nuclear medicine and biology 1984;11(3-4):287-90.
1984: R E Gibson; H H Coenen; E Jagoda; Richard C Reba; W C Eckelman
In vivo and in vitro characteristics of the N-methyl derivative of [125I]3-quinuclidinyl 4-iodobenzilate.
International journal of nuclear medicine and biology 1984;11(2):167-9.
1983: Raymond E Gibson; W J Rzeszotarski; W C Eckelman; E M Jagoda; D J Weckstein; Richard C Reba
Differences in affinities of muscarinic acetylcholine receptor antagonists for brain and heart receptors.
Biochemical pharmacology 1983;32(12):1851-6.
1982: W J Rzeszotarski; Raymond E Gibson; W C Eckelman; D A Simms; E M Jagoda; N L Ferreira; Richard C Reba
Analogues of 3-quinuclidinyl benzilate.
Journal of medicinal chemistry 1982;25(9):1103-6.
1982: B Francis; W C Eckelman; M P Grissom; Raymond E Gibson; Richard C Reba
The use of tritium labeled compounds to develop gamma-emitting receptor-binding radiotracers.
International journal of nuclear medicine and biology 1982;9(3):173-9.
1980: W C Eckelman; Raymond E Gibson; F Vieras; W J Rzeszotarski; B Francis; Richard C Reba
In vivo receptor binding of iodinated beta-adrenoceptor blockers.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1980;21(5):436-42.