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Jayagopala Reddy

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Wassim Elyaman; Pia Kivisäkk; Jayagopala Reddy; Tanuja Chitnis; Khadir Raddassi; Jaime Imitola; Elizabeth Bradshaw; Vijay K Kuchroo; Hideo Yagita; Mohamed H Sayegh; Samia J Khoury
Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis.
Zsolt Illés; Hanspeter Waldner; Jayagopala Reddy; Ana C Anderson; Raymond A Sobel; Vijay K Kuchroo
Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background.
Sheng Xiao; Nader Najafian; Jayagopala Reddy; Monica J Albin; Chen Zhu; Eric Jensen; Jaime Imitola; Thomas Korn; Ana C Anderson; Zheng Zhang; Cristina Gutierrez; Thomas Moll; Raymond A Sobel; Dale T Umetsu; Hideo Yagita; Hisaya Akiba; Terry Strom; Mohamed H Sayegh; Rosemarie H Dekruyff; Samia J Khoury; Vijay K Kuchroo
Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.

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All Publications

2008: Wassim Elyaman; Pia Kivisäkk; Jayagopala Reddy; Tanuja Chitnis; Khadir Raddassi; Jaime Imitola; Elizabeth Bradshaw; Vijay K Kuchroo; Hideo Yagita; Mohamed H Sayegh; Samia J Khoury
Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis.
The American journal of pathology 2008;173(2):411-22.
2007: Zsolt Illés; Hanspeter Waldner; Jayagopala Reddy; Ana C Anderson; Raymond A Sobel; Vijay K Kuchroo
Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background.
International immunology 2007;19(10):1235-48.
2007: Sheng Xiao; Nader Najafian; Jayagopala Reddy; Monica J Albin; Chen Zhu; Eric Jensen; Jaime Imitola; Thomas Korn; Ana C Anderson; Zheng Zhang; Cristina Gutierrez; Thomas Moll; Raymond A Sobel; Dale T Umetsu; Hideo Yagita; Hisaya Akiba; Terry Strom; Mohamed H Sayegh; Rosemarie H Dekruyff; Samia J Khoury; Vijay K Kuchroo
Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
The Journal of experimental medicine 2007;204(7):1691-702.
2007: Thomas Korn; Jayagopala Reddy; Wenda Gao; Estelle Bettelli; Amit Awasthi; Troels R Petersen; B Thomas Bäckström; Raymond A Sobel; Kai W Wucherpfennig; Terry B Strom; Mohamed Oukka; Vijay K Kuchroo
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.
Nature medicine 2007;13(4):423-31.
2006: Xingmin Zhang; Jayagopala Reddy; Hirofumi Ochi; Dan Frenkel; Vijay K Kuchroo; Howard L Weiner
Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells.
International immunology 2006;18(4):495-503.
2006: Edward Greenfield; Jayagopala Reddy; Andrew Lees; Charissa A Dyer; Omanand Koul; Khuong Nguyen; Shannon Bell; Nasim Kassam; Julian Hinojoza; Mary Jane Eaton; Marjorie B Lees; Vijay K Kuchroo; Raymond A Sobel
Monoclonal antibodies to distinct regions of human myelin proteolipid protein simultaneously recognize central nervous system myelin and neurons of many vertebrate species.
Journal of neuroscience research 2006;83(3):415-31.
2005: Zsolt Illes; Joel N H Stern; Derin B Keskin; Jayagopala Reddy; Celia F Brosnan; Hanspeter Waldner; Laura Santambrogio; Vijay K Kuchroo; Jack L Strominger
Copolymer effects on microglia and T cells in the central nervous system of humanized mice.
European journal of immunology 2005;35(12):3683-93.
2005: Jayagopala Reddy; Hanspeter Waldner; Xingmin Zhang; Zsolt Illes; Kai W Wucherpfennig; Raymond A Sobel; Vijay K Kuchroo
Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5591-5.
2005: Valerie Dardalhon; Anna S Schubart; Jayagopala Reddy; Jennifer Hartt Meyers; Laurent Monney; Catherine A Sabatos; Rakesh Ahuja; Khuong Nguyen; Gordon J Freeman; Edward Greenfield; Raymond A Sobel; Vijay K Kuchroo
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1558-65.
2005: Zsolt Illés; Hanspeter Waldner; Jayagopala Reddy; Estelle Bettelli; Lindsay B Nicholson; Vijay K Kuchroo
T cell tolerance induced by cross-reactive TCR ligands can be broken by superagonist resulting in anti-inflammatory T cell cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1491-7.
2005: Joel N H Stern; Zsolt Illés; Jayagopala Reddy; Derin B Keskin; Masha Fridkis-Hareli; Vijay K Kuchroo; Jack L Strominger
Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1620-5.
2004: Jayagopala Reddy; Zsolt Illes; Xingmin Zhang; Jeffrey Encinas; Jason Pyrdol; Lindsay Nicholson; Raymond A Sobel; Kai W Wucherpfennig; Vijay K Kuchroo
Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15434-9.
2004: Joel N H Stern; Zsolt Illés; Jayagopala Reddy; Derin B Keskin; Eric Sheu; Masha Fridkis-Hareli; Hiroyuki Nishimura; Celia F Brosnan; Laura Santambrogio; Vijay K Kuchroo; Jack L Strominger
Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11743-8.
2004: Zsolt Illés; Joel N H Stern; Jayagopala Reddy; Hanspeter Waldner; Marcin P Mycko; Celia F Brosnan; Stephan Ellmerich; Daniel M Altmann; Laura Santambrogio; Jack L Strominger; Vijay K Kuchroo
Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11749-54.
2004: Ana C Anderson; Jayagopala Reddy; Remedios F Nazareno; Raymond A Sobel; Lindsay B Nicholson; Vijay K Kuchroo
IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):828-34.
2004: Bernhard Greve; Jayagopala Reddy; Hanspeter Waldner; Raymond A Sobel; Vijay K Kuchroo
Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2(s) congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes.
European journal of immunology 2004;34(7):1828-38.
2004: Xingmin Zhang; Djordje N Koldzic; Leonid Izikson; Jayagopala Reddy; Remedios F Nazareno; Shimon Sakaguchi; Vijay K Kuchroo; Howard L Weiner
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells.
International immunology 2004;16(2):249-56.
2003: Jayagopala Reddy; Estelle Bettelli; Lindsay Nicholson; Hanspeter Waldner; Mei-Huei Jang; Kai W Wucherpfennig; Vijay K Kuchroo
Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):870-7.