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Matthew Redinbo

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Publications

TOP 3
Hao Li; Nicolin Bloch; Anik Chaudhry; Sean Ekins; Ganjam Kalpana; Paromita Mukherjee; Abdissa Negassa; Matthew R Redinbo; Madhukumar Venkatesh; Sridhar Mani
Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR.
Jonathan S Edwards; Neville Firth; Monica L Frazier; Sohrab Habibi; Julianne J Huang; Stephen M Kwong; Jordan L Meier; Rebecca M Pollet; W Keith Ballentine; Laurie Betts; Mark Del Campo; Peter B Dervan; William G Walton; Matthew R Redinbo
Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.
Sridhar Mani; Wei Dou; Matthew R Redinbo
PXR antagonists and implication in drug metabolism.

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All Publications

2013: Hao Li; Nicolin Bloch; Anik Chaudhry; Sean Ekins; Ganjam Kalpana; Paromita Mukherjee; Abdissa Negassa; Matthew R Redinbo; Madhukumar Venkatesh; Sridhar Mani
Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR.
The Journal of biological chemistry 2013;288(19):13655-68.
2013: Jonathan S Edwards; Neville Firth; Monica L Frazier; Sohrab Habibi; Julianne J Huang; Stephen M Kwong; Jordan L Meier; Rebecca M Pollet; W Keith Ballentine; Laurie Betts; Mark Del Campo; Peter B Dervan; William G Walton; Matthew R Redinbo
Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):2804-9.
2013: Sridhar Mani; Wei Dou; Matthew R Redinbo
PXR antagonists and implication in drug metabolism.
Drug metabolism reviews 2013;45(1):60-72.
2013: Eric A Porsch; Matthew R Redinbo; Angela D Broadnax; Christopher K Garrett; Michael D L Johnson; Joseph W St Geme
Calcium binding properties of the Kingella kingae PilC1 and PilC2 proteins have differential effects on type IV pilus-mediated adherence and twitching motility.
Journal of bacteriology 2013;195(4):886-95.
2013: Bret D Wallace; Matthew R Redinbo
Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective.
Drug metabolism reviews 2013;45(1):79-100.
2013: Urs A Boelsterli; Matthew R Redinbo; Kyle S Saitta
Multiple NSAID-induced hits injure the small intestine: underlying mechanisms and novel strategies.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(2):654-67.
2012: Bret D Wallace; Jamie R Wallen; Jonathan S Edwards; Wessel J A Moolman; Matthew R Redinbo; Erick Strauss; Renier van der Westhuyzen; Al Claiborne
Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights.
Biochemistry 2012;51(39):7699-711.
2012: Carey A Hobbs; Stephan Kellenberger; Mehmet Kesimer; Matthew R Redinbo; Monroe Stutts; Sompop Bencharit; Maxime G Blanchard; Rui Cao; William G Walton; Robert Tarran
Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(10):4348-59.
2012: Rebekah P Nash; Steven W Matson; Dan E McNamara; W Keith Ballentine; Matthew R Redinbo
Investigating the impact of bisphosphonates and structurally related compounds on bacteria containing conjugative plasmids.
Biochemical and biophysical research communications 2012;424(4):697-703.
2012: Amanda LoGuidice; Matthew R Redinbo; Bret D Wallace; Lauren Bendel; Urs A Boelsterli
Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice.
The Journal of pharmacology and experimental therapeutics 2012;341(2):447-54.
2011: Yuan Cheng; Monica Frazier; Falong Lu; Xiaofeng Cao; Matthew R Redinbo
Crystal structure of the plant epigenetic protein arginine methyltransferase 10.
Journal of molecular biology 2011;414(1):106-22.
2011: Yuan Cheng; Matthew R Redinbo
Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721.
Protein science : a publication of the Protein Society 2011;20(10):1713-9.
2011: Jonathan S Edwards; Amar Kumbhar; Adam Roberts; Andrew C Hemmert; Carol C Edwards; Philip Potter; Matthew R Redinbo
Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles.
Biotechnology progress 2011;27(3):863-9.
2011: Joseph V Lomino; Ashutosh Tripathy; Matthew R Redinbo
Triggered Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin folding and dimerization.
Journal of bacteriology 2011;193(9):2089-96.
2011: Rebekah P Nash; Franklin C Niblock; Matthew R Redinbo
Tyrosine partners coordinate DNA nicking by the Salmonella typhimurium plasmid pCU1 relaxase enzyme.
FEBS letters 2011;585(8):1216-22.
2011: Yuan Cheng; Dan E McNamara; Michael J Miley; Rebekah P Nash; Matthew R Redinbo
Functional characterization of the multidomain F plasmid TraI relaxase-helicase.
The Journal of biological chemistry 2011;286(14):12670-82.
2011: Syed Ahmad; Mark A Hughes; Kimberly T Lane; Matthew R Redinbo; Li-An Yeh; John E Scott
A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors.
Current chemical genomics 2011;5():13-20.
2011: Andrew C Hemmert; Tamara C Otto; Roberto A Chica; Monika Wierdl; Jonathan S Edwards; Steven L Lewis; Carol C Edwards; Lyudmila Tsurkan; C Linn Cadieux; Shane A Kasten; John R Cashman; Stephen L Mayo; Philip Potter; Douglas M Cerasoli; Steven M Lewis; Matthew R Redinbo
Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.
PloS one 2011;6(3):e17441.
2010: Bret D Wallace; Hongwei Wang; Kimberly T Lane; John E Scott; Jillian Orans; Ja-Seol Koo; Madhukumar Venkatesh; Christian Jobin; Li-An Yeh; venkatesh madhukumar; Matthew R Redinbo
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Science (New York, N.Y.) 2010;330(6005):831-5.
2010: Roger S Holmes; Matthew W Wright; Stanley J F Laulederkind; Laura A Cox; Masakiyo Hosokawa; Teruko Imai; Shun Ishibashi; Richard Lehner; Masao Miyazaki; Everett J Perkins; Phillip M Potter; Matthew R Redinbo; Jacques Robert; Tetsuo Satoh; Tetsuro Yamashita; Bingfan Yan; Tsuyoshi Yokoi; Rudolf Zechner; Lois J Maltais
Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.
Mammalian genome : official journal of the International Mammalian Genome Society 2010;21(9-10):427-41.
2010: Derek Parsonage; Gerald L Newton; Robert C Holder; Bret D Wallace; Carleitta Paige; Chris J Hamilton; Patricia C Dos Santos; Matthew R Redinbo; Sean D Reid; Al Claiborne
Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis .
Biochemistry 2010;49(38):8398-414.
2010: Rebekah Potts Nash; Sohrab Habibi; Yuan Cheng; Scott A Lujan; Matthew R Redinbo
The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1.
Nucleic acids research 2010;38(17):5929-43.
2010: Andrew C Hemmert; Tamara C Otto; Monika Wierdl; Carol C Edwards; Christopher D Fleming; Mary MacDonald; John R Cashman; Philip Potter; Douglas M Cerasoli; Matthew R Redinbo
Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.
Molecular pharmacology 2010;77(4):508-16.
2010: Anna Radominska-Pandya; Stacie Bratton; Matthew R Redinbo; Michael Miley
The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families.
Drug metabolism reviews 2010;42(1):133-44.
2010: Jillian Orans; Michael D L Johnson; Kimberly A Coggan; Justin R Sperlazza; Ryan W Heiniger; Matthew Wolfgang; Matthew R Redinbo
Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(3):1065-70.
2009: Sean Ekins; Sandhya Kortagere; Manisha Iyer; Erica J Reschly; Markus A Lill; Matthew R Redinbo; Matthew D Krasowski
Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR.
PLoS computational biology 2009;5(12):e1000594.
2009: Sarah A Kennedy; Monica L Frazier; Mindy Steiniger; Ann M Mast; William F Marzluff; Matthew R Redinbo
Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin.
Journal of molecular biology 2009;392(1):115-28.
2009: Arunima Biswas (Basu); Sridhar Mani; Matthew R Redinbo; Matthew D Krasowski; Hao Li; Ekins Sean
Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.
Pharmaceutical research 2009;26(8):1807-15.
2009: Laura M Guogas; Sarah A Kennedy; Jin Hyup Lee; Matthew R Redinbo
A novel fold in the TraI relaxase-helicase c-terminal domain is essential for conjugative DNA transfer.
Journal of molecular biology 2009;386(2):554-68.
2008: Denise G Teotico; Jason J Bischof; Li Peng; Steven A Kliewer; Matthew R Redinbo
Structural basis of human pregnane X receptor activation by the hops constituent colupulone.
Molecular pharmacology 2008;74(6):1512-20.
2008: Rebekah G Potts; Scott A Lujan; Matthew R Redinbo
Winning the asymmetric war: new strategies for combating antibacterial resistance.
Future microbiology 2008;3(2):119-23.
2008: Monika Wierdl; Lyudmila Tsurkan; Janice L Hyatt; Carol C Edwards; M Jason Hatfield; Christopher L Morton; Peter J Houghton; Mary K Danks; Matthew R Redinbo; Philip Potter
An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.
Cancer gene therapy 2008;15(3):183-92.
2008: Gabriel Schaaf; Eric ORTLUND; Kimberly R Tyeryar; Carl J Mousley; Kristina E Ile; Teresa A Garrett; Jihui Ren; Melissa J Woolls; Christian R H Raetz; Matthew R Redinbo; Vytas A Bankaitis
Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily.
Molecular cell 2008;29(2):191-206.
2008: Denise G Teotico; Monica L Frazier; Feng Ding; Nikolay V Dokholyan; Brenda Temple; Matthew R Redinbo
Active nuclear receptors exhibit highly correlated AF-2 domain motions.
PLoS computational biology 2008;4(7):e1000111.
2007: Eric ORTLUND; Jamie T Bridgham; Matthew R Redinbo; Joseph W Thornton
Crystal structure of an ancient protein: evolution by conformational epistasis.
Science (New York, N.Y.) 2007;317(5844):1544-8.
2007: Scott A Lujan; Laura M Guogas; Heather Ragonese; Steven W Matson; Matthew R Redinbo
Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12282-7.
2007: Michael Miley; Agnieszka K Zielinska; Jeffrey E Keenan; Stacie Bratton; Anna Radominska-Pandya; Matthew R Redinbo
Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7.
Journal of molecular biology 2007;369(2):498-511.
2007: Christopher D Fleming; Carol C Edwards; Stephen D Kirby; Donald M Maxwell; Philip Potter; Douglas M Cerasoli; Matthew R Redinbo
Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun.
Biochemistry 2007;46(17):5063-71.
2007: Yu Xue; Linda B Moore; Jillian Orans; Li Peng; Sompop Bencharit; Steven A Kliewer; Matthew R Redinbo
Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition.
Molecular endocrinology (Baltimore, Md.) 2007;21(5):1028-38.
2007: Hongwei Wang; Haiyan Huang; Hao Li; Denise G Teotico; Michael Sinz; Sharyn D Baker; Jeffrey Staudinger; Ganjam V Kalpana; Matthew R Redinbo; Sridhar Mani
Activated pregnenolone X-receptor is a target for ketoconazole and its analogs.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(8):2488-95.
2007: Yu Xue; Esther Chao; William J Zuercher; Timothy M Willson; Jon L Collins; Matthew R Redinbo
Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.
Bioorganic & medicinal chemistry 2007;15(5):2156-66.
2007: Randy M Wadkins; Janice L Hyatt; Carol C Edwards; Lyudmila Tsurkan; Matthew R Redinbo; Craig E Wheelock; Paul D Jones; Bruce D Hammock; Philip Potter
Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.
Molecular pharmacology 2007;71(3):713-23.
2007: Haiyan Huang; Hongbing Wang; Michael Sinz; M Zoeckler; J Staudinger; Matthew R Redinbo; Denise G Teotico; Joseph Locker; Ganjam V Kalpana; Sridhar Mani
Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.
Oncogene 2007;26(2):258-68.
2006: Sompop Bencharit; Carol C Edwards; Christopher L Morton; Escher L Howard-Williams; Peter Kuhn; Philip Potter; Matthew R Redinbo
Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1.
Journal of molecular biology 2006;363(1):201-14.
2006: Schroeder M Noble; Virginia E Carnahan; Linda B Moore; Tom Luntz; Hongbing Wang; Olivia R Ittoop; Julie B Stimmel; Paula R Davis-Searles; Ryan E Watkins; G Bruce Wisely; Edward LeCluyse; Ashutosh Tripathy; Donald P McDonnell; Matthew R Redinbo
Human PXR forms a tryptophan zipper-mediated homodimer.
Biochemistry 2006;45(28):8579-89.
2005: Isaac H Solomon; Janet M Hager; Rachid Safi; Donald P McDonnell; Matthew R Redinbo; Eric ORTLUND
Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
Journal of molecular biology 2005;354(5):1091-102.
2005: Holly A Ingraham; Matthew R Redinbo
Orphan nuclear receptors adopted by crystallography.
Current opinion in structural biology 2005;15(6):708-15.
2005: Jillian Orans; Denise G Teotico; Matthew R Redinbo
The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges.
Molecular endocrinology (Baltimore, Md.) 2005;19(12):2891-900.
2005: Christopher D Fleming; Sompop Bencharit; Carol C Edwards; Janice L Hyatt; Lyudmila Tsurkan; Feng Bai; Charles Fraga; Christopher L Morton; Escher L Howard-Williams; Philip Potter; Matthew R Redinbo
Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
Journal of molecular biology 2005;352(1):165-77.
2005: Huazhang Huang; Christopher D Fleming; Kosuke Nishi; Matthew R Redinbo; Bruce D Hammock
Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases.
Chemical research in toxicology 2005;18(9):1371-7.
2005: Virginia E Carnahan; Matthew R Redinbo
Structure and function of the human nuclear xenobiotic receptor PXR.
Current drug metabolism 2005;6(4):357-67.
2005: Jill E Chrencik; Jillian Orans; Linda B Moore; Yu Xue; Li Peng; Jon L Collins; G Bruce Wisely; Millard H Lambert; Steven A Kliewer; Matthew R Redinbo
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.
Molecular endocrinology (Baltimore, Md.) 2005;19(5):1125-34.
2005: Eric ORTLUND; Yoonkwang Lee; Isaac H Solomon; Janet M Hager; Rachid Safi; Yunhee Choi; Ziqiang Guan; Ashutosh Tripathy; Christian R H Raetz; Donald P McDonnell; David D Moore; Matthew R Redinbo
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
Nature structural & molecular biology 2005;12(4):357-63.
2005: Matthew R Redinbo; Philip Potter
Mammalian carboxylesterases: from drug targets to protein therapeutics.
Drug discovery today 2005;10(5):313-25.
2004: Roopa Thapar; William F Marzluff; Matthew R Redinbo
Electrostatic contribution of serine phosphorylation to the Drosophila SLBP--histone mRNA complex.
Biochemistry 2004;43(29):9401-12.
2004: Jill E Chrencik; Bart L Staker; Alex B Burgin; Philippe Pourquier; Yves Pommier; Lance Stewart; Matthew R Redinbo
Mechanisms of camptothecin resistance by human topoisomerase I mutations.
Journal of molecular biology 2004;339(4):773-84.
2004: Matthew R Redinbo
Promiscuity: what protects us, perplexes us.
Drug discovery today 2004;9(10):431-2.
2004: Monika Wierdl; Christopher L Morton; Nathan K Nguyen; Matthew R Redinbo; Philip Potter
Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.
Biochemistry 2004;43(7):1874-82.
2003: Ryan E Watkins; Paula R Davis-Searles; Millard H Lambert; Matthew R Redinbo
Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor.
Journal of molecular biology 2003;331(4):815-28.
2003: Matthew R Redinbo; Sompop Bencharit; Philip Potter
Human carboxylesterase 1: from drug metabolism to drug discovery.
Biochemical Society transactions 2003;31(Pt 3):620-4.
2003: Sompop Bencharit; Christopher L Morton; Yu Xue; Philip Potter; Matthew R Redinbo
Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme.
Nature structural biology 2003;10(5):349-56.
2003: Jill E Chrencik; Alex B Burgin; Yves Pommier; Lance Stewart; Matthew R Redinbo
Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex.
The Journal of biological chemistry 2003;278(14):12461-6.
2003: Sompop Bencharit; Christopher L Morton; Janice L Hyatt; Peter Kuhn; Mary K Danks; Philip Potter; Matthew R Redinbo
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.
Chemistry & biology 2003;10(4):341-9.
2003: Ryan E Watkins; Jodi M Maglich; Linda B Moore; G Bruce Wisely; Schroeder M Noble; Paula R Davis-Searles; Millard H Lambert; Steven A Kliewer; Matthew R Redinbo
2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.
Biochemistry 2003;42(6):1430-8.
2002: Diem-Thu Thieu Lesher; Yves Pommier; Lance Stewart; Matthew R Redinbo
8-Oxoguanine rearranges the active site of human topoisomerase I.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12102-7.
2002: Sompop Bencharit; Christopher L Morton; Escher L Howard-Williams; Mary K Danks; Philip Potter; Matthew R Redinbo
Structural insights into CPT-11 activation by mammalian carboxylesterases.
Nature structural biology 2002;9(5):337-42.
2002: Yu Xue; Glenn C Ratcliff; Hong Wang; Paula R Davis-Searles; Matthew D Gray; Dorothy A Erie; Matthew R Redinbo
A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities.
Biochemistry 2002;41(9):2901-12.
2002: Ryan E Watkins; Schroeder M Noble; Matthew R Redinbo
Structural insights into the promiscuity and function of the human pregnane X receptor.
Current opinion in drug discovery & development 2002;5(1):150-8.
2002: Bryan Goodwin; Matthew R Redinbo; Steven A Kliewer
Regulation of cyp3a gene transcription by the pregnane x receptor.
Annual review of pharmacology and toxicology 2002;42():1-23.
2001: Ryan E Watkins; G Bruce Wisely; Linda B Moore; Jon L Collins; Millard H Lambert; Shawn P Williams; Timothy M Willson; Steven A Kliewer; Matthew R Redinbo
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.
Science (New York, N.Y.) 2001;292(5525):2329-33.