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Juan Miguel Redondo

Research Profile

Chemicals & Drugs

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M Dolores Salvado; Arántzazu Alfranca; Jesper Z Haeggström; Juan Miguel Redondo
Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2.
Patricia Rodríguez; Fernando Rodríguez-Pascual; Maria José Ruiz-Hidalgo; María Monsalve; Juan Miguel Redondo; Arántzazu Alfranca; José Luis de la Pompa; Marta Fierro-Fernández; Rosa Ana García-Fernández; Alvaro González-Rajal; María Angeles Higueras; Jorge Laborda; Santiago Lamas
The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis.
Elena Bonzon-Kulichenko; Sara Martínez-Martínez; Pedro José Navarro; Juan Miguel Redondo; Marco Trevisan-Herraz; Jesús Vázquez
Quantitative in-depth analysis of the dynamic secretome of activated Jurkat T-cells.

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2012: M Dolores Salvado; Arántzazu Alfranca; Jesper Z Haeggström; Juan Miguel Redondo
Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2.
Trends in molecular medicine 2012;18(4):233-43.
2012: Patricia Rodríguez; Fernando Rodríguez-Pascual; Maria José Ruiz-Hidalgo; María Monsalve; Juan Miguel Redondo; Arántzazu Alfranca; José Luis de la Pompa; Marta Fierro-Fernández; Rosa Ana García-Fernández; Alvaro González-Rajal; María Angeles Higueras; Jorge Laborda; Santiago Lamas
The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis.
Cardiovascular research 2012;93(2):232-41.
2011: Elena Bonzon-Kulichenko; Sara Martínez-Martínez; Pedro José Navarro; Juan Miguel Redondo; Marco Trevisan-Herraz; Jesús Vázquez
Quantitative in-depth analysis of the dynamic secretome of activated Jurkat T-cells.
Journal of proteomics 2011;75(2):561-71.
2011: Vanesa Esteban; Nerea Méndez-Barbero; Laura Novensá; Mercè Roqué; Mercedes Salaices; Luis Vila; Ana Belén García-Redondo; Luis Jesús Jiménez-Borreguero; María L Arbonés; Miguel R Campanero; Juan Miguel Redondo
Regulator of calcineurin 1 mediates pathological vascular wall remodeling.
The Journal of experimental medicine 2011;208(10):2125-39.
2011: Katia Urso; Antonio Rodríguez; Arántzazu Alfranca; Amelia Escolano; Sara Martínez-Martínez; Inmaculada Ortega; Juan Miguel Redondo
NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis.
Blood 2011;118(3):795-803.
2011: Elena Bonzon-Kulichenko; Daniel Pérez-Hernández; Estefanía Núñez; Pablo Martínez-Acedo; Pedro José Navarro; Marco Trevisan-Herraz; María del Carmen Ramos; Saleta Sierra; Sara Martínez-Martínez; Marisol Ruiz-Meana; Elizabeth Miró-Casas; David García-Dorado; Juan Miguel Redondo; Javier S Burgos; Jesús Vázquez
A robust method for quantitative high-throughput analysis of proteomes by 18O labeling.
Molecular & cellular proteomics : MCP 2011;10(1):M110.003335.
2009: M Dolores Salvado; Arántzazu Alfranca; Amelia Escolano; Jesper Z Haeggström; Juan Miguel Redondo
COX-2 limits prostanoid production in activated HUVECs and is a source of PGH2 for transcellular metabolism to PGE2 by tumor cells.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(7):1131-7.
2009: Inmaculada Jorge; Pedro José Navarro; Pablo Martínez-Acedo; Estefanía Núñez; Horacio Serrano; Arántzazu Alfranca; Juan Miguel Redondo; Jesús Vázquez
Statistical model to analyze quantitative proteomics data obtained by 18O/16O labeling and linear ion trap mass spectrometry: application to the study of vascular endothelial growth factor-induced angiogenesis in endothelial cells.
Molecular & cellular proteomics : MCP 2009;8(5):1130-49.
2009: Sara Martínez-Martínez; Lali Genescà; Antonio Rodríguez; Alicia Raya; Eulàlia Salichs; Felipe Were; María Dolores López-Maderuelo; Juan Miguel Redondo; Susana de la Luna
The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6117-22.
2009: Antonio Rodríguez; Jagoree Roy; Sara Martínez-Martínez; María Dolores López-Maderuelo; Perla Niño-Moreno; Leticia Ortí; David Pantoja-Uceda; Antonio Pineda-Lucena; Martha S Cyert; Juan Miguel Redondo
A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
Molecular cell 2009;33(5):616-26.
2009: Josué Alvaro-Blanco; Lorena Martínez-Gac; Esther Calonge; María Rodríguez-Martínez; Irene Molina-Privado; Juan Miguel Redondo; José Alcamí; Erik K Flemington; Miguel R Campanero
A novel factor distinct from E2F mediates C-MYC promoter activation through its E2F element during exit from quiescence.
Carcinogenesis 2009;30(3):440-8.
2008: Arántzazu Alfranca; Juan Manuel López-Oliva; Laura Genís; Dolores López-Maderuelo; Isabel Mirones; Dolores Salvado; Antonio J Quesada; Alicia G Arroyo; Juan Miguel Redondo
PGE2 induces angiogenesis via MT1-MMP-mediated activation of the TGFbeta/Alk5 signaling pathway.
Blood 2008;112(4):1120-8.
2008: Andrea Canellada; Belén G Ramirez; Takashi Minami; Juan Miguel Redondo; Eva Cano
Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes.
Glia 2008;56(7):709-22.
2007: Inmaculada Jorge; Elisabet Miró Casas; Margarita Villar; Inmaculada Ortega-Pérez; Daniel López-Ferrer; Antonio Martínez-Ruiz; Mónica Carrera; Anabel Marina; Pablo Martínez; Horacio Serrano; Benito Cañas; Felipe Were; José Manuel Gallardo; Santiago Lamas; Juan Miguel Redondo; David García-Dorado; Jesús Vázquez
High-sensitivity analysis of specific peptides in complex samples by selected MS/MS ion monitoring and linear ion trap mass spectrometry: application to biological studies.
Journal of mass spectrometry : JMS 2007;42(11):1391-403.
2007: Laura Piqueras; Andrew R Reynolds; Kairbaan M Hodivala-Dilke; Arántzazu Alfranca; Juan Miguel Redondo; Toshihisa Hatae; Tadashi Tanabe; Timothy D Warner; David Bishop-Bailey
Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(1):63-9.
2006: Arántzazu Alfranca; Miguel A Iñiguez; Manuel Fresno; Juan Miguel Redondo
Prostanoid signal transduction and gene expression in the endothelium: role in cardiovascular diseases.
Cardiovascular research 2006;70(3):446-56.
2006: María E Pacheco; Amada Beltrán; Juan Miguel Redondo; Ana M Manso; María J Alonso; Mercedes Salaices
High glucose enhances inducible nitric oxide synthase expression. Role of protein kinase C-betaII.
European journal of pharmacology 2006;538(1-3):115-23.
2006: Margarita Villar; Inmaculada Ortega-Pérez; Felipe Were; Eva Cano; Juan Miguel Redondo; Jesús Vázquez
Systematic characterization of phosphorylation sites in NFATc2 by linear ion trap mass spectrometry.
Proteomics 2006;6 Suppl 1():S16-27.
2006: Andrea Canellada; Eva Cano; Lucía Sánchez-Ruiloba; Francisco Zafra; Juan Miguel Redondo
Calcium-dependent expression of TNF-alpha in neural cells is mediated by the calcineurin/NFAT pathway.
Molecular and cellular neurosciences 2006;31(4):692-701.
2006: Sara Martínez-Martínez; Antonio Rodríguez; Maria Dolores López-Maderuelo; Inmaculada Ortega-Pérez; Jesús Vázquez; Juan Miguel Redondo
Blockade of NFAT activation by the second calcineurin binding site.
The Journal of biological chemistry 2006;281(10):6227-35.
2005: Eva Cano; Andrea Canellada; Takashi Minami; Teresa Iglesias; Juan Miguel Redondo
Depolarization of neural cells induces transcription of the Down syndrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway.
The Journal of biological chemistry 2005;280(33):29435-43.
2005: Mamta H Buch; Adam Pickard; Antonio Rodriguez; Sheona Gillies; Alexander H Maass; Michael Emerson; Elizabeth J Cartwright; Judith C Williams; Delvac Oceandy; Juan Miguel Redondo; Ludwig Neyses; Angel L Armesilla
The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit.
The Journal of biological chemistry 2005;280(33):29479-87.
2005: Antonio Jesús Quesada; Thomas Nelius; Ronald L Yap; Tetiana Zaichuk; Arántzazu Alfranca; Stephanie Filleur; Olga V Volpert; Juan Miguel Redondo
In vivo upregulation of CD95 and CD95L causes synergistic inhibition of angiogenesis by TSP1 peptide and metronomic doxorubicin treatment.
Cell death and differentiation 2005;12(6):649-58.
2005: Inmaculada Ortega-Pérez; Eva Cano; Felipe Were; Margarita Villar; Jesús Vázquez; Juan Miguel Redondo
c-Jun N-terminal kinase (JNK) positively regulates NFATc2 transactivation through phosphorylation within the N-terminal regulatory domain.
The Journal of biological chemistry 2005;280(21):20867-78.
2005: Antonio Rodríguez; Sara Martínez-Martínez; Ma Dolores López-Maderuelo; Inmaculada Ortega-Pérez; Juan Miguel Redondo
The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.
The Journal of biological chemistry 2005;280(11):9980-4.
2004: Carmen Ruiz-Ruiz; Carmen Ruiz de Almodóvar; Antonio Rodríguez; Gustavo Ortiz-Ferrón; Juan Miguel Redondo; Abelardo López-Rivas
The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1.
The Journal of biological chemistry 2004;279(19):19712-20.
2004: Sara Martínez-Martínez; Juan Miguel Redondo
Inhibitors of the calcineurin/NFAT pathway.
Current medicinal chemistry 2004;11(8):997-1007.
2004: Carmen Ruiz de Almodóvar; Carmen Ruiz-Ruiz; Antonio Rodríguez; Gustavo Ortiz-Ferrón; Juan Miguel Redondo; Abelardo López-Rivas
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site.
The Journal of biological chemistry 2004;279(6):4093-101.
2004: Carmen Ruiz de Almodóvar; Abelardo López-Rivas; Juan Miguel Redondo; Antonio Rodríguez
Transcriptional regulation of the TRAIL-R3 gene.
Vitamins and hormones 2004;67():51-63.
2003: Carmen Ruiz-Ruiz; Gema Robledo; Eva Cano; Juan Miguel Redondo; Abelardo Lopez-Rivas
Characterization of p53-mediated up-regulation of CD95 gene expression upon genotoxic treatment in human breast tumor cells.
The Journal of biological chemistry 2003;278(34):31667-75.
2003: Miguel A Iñiguez; Antonio Rodríguez; Olga V Volpert; Manuel Fresno; Juan Miguel Redondo
Cyclooxygenase-2: a therapeutic target in angiogenesis.
Trends in molecular medicine 2003;9(2):73-8.
2003: Antonio Jesús Quesada; Juan Miguel Redondo
[CA++/ calcineurin/NFAT signaling in endothelial activation and angiogenesis: effects od cyclosporin A ].
Nefrología : publicación oficial de la Sociedad Española Nefrologia 2003;23 Suppl 3():44-8.
2002: Carmen Ruiz de Almodóvar; Abelardo López-Rivas; Juan Miguel Redondo; Antonio Rodríguez
Transcription initiation sites and promoter structure of the human TRAIL-R3 gene.
FEBS letters 2002;531(2):304-8.
2002: Marta Carretero; Marta Gómez-Gonzalo; Enrique Lara-Pezzi; Ignacio Benedicto; José Aramburu; Sara Martínez-Martínez; Juan Miguel Redondo; Manuel López-Cabrera
The hepatitis B virus X protein binds to and activates the NH(2)-terminal trans-activation domain of nuclear factor of activated T cells-1.
Virology 2002;299(2):288-300.
2002: Encarnación Lorenzo; Carmen Ruiz-Ruiz; Antonio Jesús Quesada; Gabriela Hernández; Antonio Rodríguez; Abelardo López-Rivas; Juan Miguel Redondo
Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.
The Journal of biological chemistry 2002;277(13):10883-92.
2001: Raquel Hernanz; Jesús Marín; L Hernández; Mercedes Salaices; Juan Miguel Redondo; María J Alonso
University of Wisconsin solution increases hyperpolarizing mechanisms in response to bradykinin.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2001;20(12):1317-24.
2001: Juan Miguel Redondo; María E Pacheco; Ana M Manso; Mercedes Salaices; Jesús Marín
Cell volume and ionic transport systems after cold preservation of coronary endothelial cells.
The Annals of thoracic surgery 2001;71(4):1290-5.
2001: G L Hernández; Olga V Volpert; Miguel A Iñiguez; Encarnación Lorenzo; Sara Martínez-Martínez; Raquel Grau; Manuel Fresno; Juan Miguel Redondo
Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2.
The Journal of experimental medicine 2001;193(5):607-20.
2000: Juan Miguel Redondo; Ana M Manso; María E Pacheco; L Hernández; Mercedes Salaices; Jesús Marín
Hypothermic storage of coronary endothelial cells reduces nitric oxide synthase activity and expression.
Cryobiology 2000;41(4):292-300.
2000: Miguel A Iñiguez; S Martinez-Martinez; Carmen Punzón; Juan Miguel Redondo; Manuel Fresno
An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes.
The Journal of biological chemistry 2000;275(31):23627-35.
2000: María E Pacheco; Jesús Marín; Ana M Manso; María Rodríguez-Martínez; Ana M Briones; Mercedes Salaices; Juan Miguel Redondo
Nitric oxide synthase induction by ouabain in vascular smooth muscle cells from normotensive and hypertensive rats.
Journal of hypertension 2000;18(7):877-84.
2000: P Gómez del Arco; Sara Martínez-Martínez; J L Maldonado; Inmaculada Ortega-Pérez; Juan Miguel Redondo
A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp.
The Journal of biological chemistry 2000;275(18):13872-8.
2000: Ana M Manso; A Encabo; Juan Miguel Redondo; Mercedes Salaices; Jesús Marín
Different sensitivity of isoprenaline-induced responses in ventricular muscle to sodium nitroprusside in normotensive and spontaneously hypertensive rats.
Journal of autonomic pharmacology 2000;20(2):77-85.
2000: Samuel Ogueta; R Rogado; Anabel Marina; F Moreno; Juan Miguel Redondo; Jesús Vázquez
Identification of phosphorylation sites in proteins by nanospray quadrupole ion trap mass spectrometry.
Journal of mass spectrometry : JMS 2000;35(4):556-65.
2000: Inmaculada Ortega-Pérez; Juan Miguel Redondo
[The NFAT transcription factor family as immunosuppression target].
Nefrología : publicación oficial de la Sociedad Española Nefrologia 2000;20 Suppl 2():25-30.
1999: Jesús Marín; Juan Miguel Redondo
Vascular sodium pump: endothelial modulation and alterations in some pathological processes and aging.
Pharmacology & therapeutics 1999;84(3):249-71.
1999: Pilar Lauzurica; Sara Martínez-Martínez; Mónica Marazuela; P Gómez del Arco; C Martínez; Francisco Sánchez-Madrid; Juan Miguel Redondo
Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-alpha.
European journal of immunology 1999;29(6):1890-900.
1999: Angel L Armesilla; Encarnación Lorenzo; P Gómez del Arco; Sara Martínez-Martínez; Arántzazu Alfranca; Juan Miguel Redondo
Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression.
Molecular and cellular biology 1999;19(3):2032-43.
1998: Enrique Lara-Pezzi; Angel L Armesilla; Pedro Majano; Juan Miguel Redondo; Manuel López-Cabrera
The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway.
The EMBO journal 1998;17(23):7066-77.
1998: María Rodríguez-Martínez; María J Alonso; Juan Miguel Redondo; M Salaíces; Jesús Marín
Role of lipid peroxidation and the glutathione-dependent antioxidant system in the impairment of endothelium-dependent relaxations with age.
British journal of pharmacology 1998;123(1):113-21.
1997: P Gomez del Arco; Sara Martínez-Martínez; V Calvo; Angel L Armesilla; Juan Miguel Redondo
Antioxidants and AP-1 activation: a brief overview.
Immunobiology 1997;198(1-3):273-8.
1997: Sara Martínez-Martínez; P Gómez del Arco; Angel L Armesilla; José Aramburu; C Luo; A Rao; Juan Miguel Redondo
Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.
Molecular and cellular biology 1997;17(11):6437-47.
1996: Juan Miguel Redondo; María Rodríguez-Martínez; María J Alonso; Mercedes Salaices; Gloria Balfagón; Jesús Marín
Endothelium stimulates the vascular smooth muscle cell Na/K pump of normotensive and hypertensive rats by a protein kinase C pathway.
Journal of hypertension 1996;14(11):1301-7.
1996: C Muñoz; D Pascual-Salcedo; M C Castellanos; Arántzazu Alfranca; J Aragonés; A Vara; Juan Miguel Redondo; Manuel O de Landázuri
Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity.
Blood 1996;88(9):3482-90.
1996: P Gómez del Arco; Sara Martínez-Martínez; Victor Calvo; Angel L Armesilla; Juan Miguel Redondo
JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes.
The Journal of biological chemistry 1996;271(42):26335-40.
1996: C Muñoz; M C Castellanos; Arántzazu Alfranca; A Vara; M A Esteban; Juan Miguel Redondo; Manuel O de Landázuri
Transcriptional up-regulation of intracellular adhesion molecule-1 in human endothelial cells by the antioxidant pyrrolidine dithiocarbamate involves the activation of activating protein-1.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3587-97.
1996: J Aragonés; C López-Rodríguez; Angel L Corbí; P G del Arco; Manuel López-Cabrera; Manuel O de Landázuri; Juan Miguel Redondo
Dithiocarbamates trigger differentiation and induction of CD11c gene through AP-1 in the myeloid lineage.
The Journal of biological chemistry 1996;271(18):10924-31.
1995: Juan Miguel Redondo; Concepcion Peiro; Leocadio Rodríguez-Mañas; Mercedes Salaices; Jesús Marín; Carlos F Sánchez-Ferrer
Endothelial stimulation of sodium pump in cultured vascular smooth muscle.
Hypertension 1995;26(1):177-85.
1995: Concepcion Peiro; Juan Miguel Redondo; María Rodríguez-Martínez; Javier Angulo; Jesús Marín; Carlos F Sánchez-Ferrer
Influence of endothelium on cultured vascular smooth muscle cell proliferation.
Hypertension 1995;25(4 Pt 2):748-51.
1993: A Encabo; Mercedes Ferrer; Jesús Marín; Concepcion Peiro; Juan Miguel Redondo; M R de Sagarra; Gloria Balfagón
Phorbol dibutyrate induces contractions in bovine cerebral arteries by an extracellular calcium-independent mechanism.
The Journal of pharmacy and pharmacology 1993;45(4):274-9.
1993: Carlos F Sánchez-Ferrer; A Ponte; M A Casado; Leocadio Rodríguez-Mañas; A Pareja; Rita González; M S Fernández-Alfonso; Juan Miguel Redondo; Jesús Marín
Endothelial modulation of the vascular sodium pump.
Journal of cardiovascular pharmacology 1993;22 Suppl 2():S99-101.
1992: Mercedes Ferrer; A Encabo; Jesús Marín; Concepcion Peiro; Juan Miguel Redondo; M R de Sagarra; Gloria Balfagón
Comparison of the vasoconstrictor responses induced by endothelin and phorbol 12,13-dibutyrate in bovine cerebral arteries.
Brain research 1992;599(2):186-96.
1992: Concepcion Peiro; M Rosa de Sagarra; Juan Miguel Redondo; Carlos F Sánchez-Ferrer; Jesús Marín
Vascular smooth muscle proliferation in hypertensive transgenic rats.
Journal of cardiovascular pharmacology 1992;20 Suppl 12():S128-31.
1990: Eva Cano; Angel Pizarro; Juan Miguel Redondo; Francisco Sánchez-Madrid; Carmelo Bernabeu; Manuel Fresno
Induction of T cell activation by monoclonal antibodies specific for the transferrin receptor.
European journal of immunology 1990;20(4):765-70.
1989: M Izquierdo; Juan Miguel Redondo; M A Balboa; Abelardo López-Rivas; E J Cragoe; L Vázquez; J M Fernández-Rañada; Miguel López-Botet
Deficient protein kinase C-dependent Na+/H+ exchanger activity in T cells from bone marrow transplantation recipients.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(7):2185-92.
1989: J A Lopez Guerrero; Juan Miguel Redondo; Balbino Alarcon; Francisco Sánchez-Madrid; M Rodríguez Moya; M Ortíz de Landazuri; Carmelo Bernabeu; Manuel Fresno
Different functional domains on the transferrin receptor molecule defined by monoclonal antibodies.
Immunology 1989;66(2):252-7.
1988: Juan Miguel Redondo; Abelardo López-Rivas; V Vila; E J Cragoe; Manuel Fresno
The role of protein kinase C in T lymphocyte proliferation. Existence of protein kinase C-dependent and -independent pathways.
The Journal of biological chemistry 1988;263(33):17467-70.
1988: Juan Miguel Redondo; Manuel Fresno; Abelardo López-Rivas
Inhibition of interleukin 2-induced proliferation of cloned murine T cells by glucocorticoids. Possible involvement of an inhibitory protein.
European journal of immunology 1988;18(10):1555-9.
1988: Balbino Alarcon; Juan Miguel Redondo; H Bugany; L Carrasco; Manuel Fresno
Inhibition of natural killer cytotoxicity by extracellular ppp(A2'p5')nA oligonucleotides.
International journal of immunopharmacology 1988;10(1):73-80.