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Charles Redwood

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Christopher R Bayliss; O'neal Copeland; Cristobal Dos Remedios; Clare E Gallon; Adam M Jacques; Man-Ching Leung; Steven B Marston; William J McKenna; Charles Redwood; Douglas G Ward; Andrew E Messer
Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
Katalin Pinter; Gabor Czibik; Hend Farza; Robert T Grignani; Hugh Watkins; Charles Redwood
Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart.
Sandra Marisa Oliveira; Katalin Pinter; Houman Ashrafian; Mohamed Bellahcene; David Carling; Barbara Casadei; Joanna K Davies; Ying Ge; Henrik Isackson; Raquel Sancho Solis; Jeffery W Walker; Hugh Watkins; Arash Yavari; Yin-Hua Zhang; Charles Redwood
AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.

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2013: Christopher R Bayliss; O'neal Copeland; Cristobal Dos Remedios; Clare E Gallon; Adam M Jacques; Man-Ching Leung; Steven B Marston; William J McKenna; Charles Redwood; Douglas G Ward; Andrew E Messer
Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
Cardiovascular research 2013;97(3):500-8.
2012: Katalin Pinter; Gabor Czibik; Hend Farza; Robert T Grignani; Hugh Watkins; Charles Redwood
Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart.
Journal of molecular and cellular cardiology 2012;53(3):342-9.
2012: Sandra Marisa Oliveira; Katalin Pinter; Houman Ashrafian; Mohamed Bellahcene; David Carling; Barbara Casadei; Joanna K Davies; Ying Ge; Henrik Isackson; Raquel Sancho Solis; Jeffery W Walker; Hugh Watkins; Arash Yavari; Yin-Hua Zhang; Charles Redwood
AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.
Circulation research 2012;110(9):1192-201.
2012: Katalin Pinter; Gabor Czibik; Andrew Jefferson; Hugh Watkins; Charles Redwood
Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification.
Cell cycle (Georgetown, Tex.) 2012;11(5):917-21.
2011: Hugh Watkins; Houman Ashrafian; Charles Redwood
Inherited cardiomyopathies.
The New England journal of medicine 2011;364(17):1643-56.
2010: Weihua Song; Emma Dyer; Daniel Stuckey; Man-Ching Leung; Massimiliano Memo; Catherine Mansfield; Michael Ferenczi; Ke Liu; Charles Redwood; Kristen Nowak; Sian Harding; Kieran Clarke; Dominic Wells; Steven B Marston
Investigation of a transgenic mouse model of familial dilated cardiomyopathy.
Journal of molecular and cellular cardiology 2010;49(3):380-9.
2009: Peter J Griffiths; H Isackson; R Pelc; Charles Redwood; S S Funari; Hugh Watkins; Christopher C Ashley
Synchronous in situ ATPase activity, mechanics, and Ca2+ sensitivity of human and porcine myocardium.
Biophysical journal 2009;97(9):2503-12.
2009: Sebastian Carballo; Paul Robinson; Robyn Otway; Diane Fatkin; Jan D H Jongbloed; Nicolaas de Jonge; Edward Blair; J Peter van Tintelen; Charles Redwood; Hugh Watkins
Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy.
Circulation research 2009;105(4):375-82.
2009: Bernhard Renz; Joanna K Davies; David Carling; Hugh Watkins; Charles Redwood
Determination of AMP-activated protein kinase phosphorylation sites in recombinant protein expressed using the pET28a vector: a cautionary tale.
Protein expression and purification 2009;66(2):181-4.
2009: Steven B Marston; O'neal Copeland; Adam Jacques; Karen Livesey; Victor Tsang; William J McKenna; Shapour Jalilzadeh; Sebastian Carballo; Charles Redwood; Hugh Watkins
Evidence from human myectomy samples that MYBPC3 mutations cause hypertrophic cardiomyopathy through haploinsufficiency.
Circulation research 2009;105(3):219-22.
2008: S J Fisher; John R Helliwell; S Khurshid; L Govada; Charles Redwood; John M Squire; Naomi E Chayen
An investigation into the protonation states of the C1 domain of cardiac myosin-binding protein C.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 6):658-64.
2008: Lata Govada; Liz Carpenter; Paula C A da Fonseca; John R Helliwell; Pierre J Rizkallah; Emily Flashman; Naomi E Chayen; Charles Redwood; John M Squire
Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy.
Journal of molecular biology 2008;378(2):387-97.
2008: Emily Flashman; L Korkie; Hugh Watkins; Charles Redwood; Johanna C Moolman-Smook
Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle.
FEBS letters 2008;582(3):434-8.
2008: Yin Hua Zhang; Mei Hua Zhang; Claire E Sears; Krzysztof Emanuel; Charles Redwood; Ali El-Armouche; Evangelia G Kranias; Barbara Casadei
Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice.
Circulation research 2008;102(2):242-9.
2007: Paul Robinson; Peter J Griffiths; Hugh Watkins; Charles Redwood
Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.
Circulation research 2007;101(12):1266-73.
2007: Laura C Preston; Christopher C Ashley; Charles Redwood
DCM troponin C mutant Gly159Asp blunts the response to troponin phosphorylation.
Biochemical and biophysical research communications 2007;360(1):27-32.
2007: Mahmooda Mirza; Paul Robinson; Elena Kremneva; O'neal Copeland; Olga P Nikolaeva; Hugh Watkins; Dmitrii I Levitsky; Charles Redwood; Mohammed El Mezgueldi; Steven B Marston
The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments.
The Journal of biological chemistry 2007;282(18):13487-97.
2007: Paul Robinson; Simon Lipscomb; Laura C Preston; Elissa Altin; Hugh Watkins; Christopher C Ashley; Charles Redwood
Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(3):896-905.
2007: Laura C Preston; Simon Lipscomb; Paul Robinson; Jens Mogensen; William J McKenna; Hugh Watkins; Christopher C Ashley; Charles Redwood
Functional effects of the DCM mutant Gly159Asp troponin C in skinned muscle fibres.
Pflügers Archiv : European journal of physiology 2007;453(6):771-6.
2007: Emily Flashman; Hugh Watkins; Charles Redwood
Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod.
The Biochemical journal 2007;401(1):97-102.
2006: Laura C Preston; Hugh Watkins; Charles Redwood
A revised method of troponin exchange in permeabilised cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I.
Journal of muscle research and cell motility 2006;27(8):585-90.
2005: Mahmooda Mirza; Steven B Marston; Ruth Willott; Christopher C Ashley; Jens Mogensen; William McKenna; Paul Robinson; Charles Redwood; Hugh Watkins
Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype.
The Journal of biological chemistry 2005;280(31):28498-506.
2005: Simon Lipscomb; Laura C Preston; Paul Robinson; Charles Redwood; Ian P Mulligan; Christopher C Ashley
Effects of troponin C isoform on the action of the cardiotonic agent EMD 57033.
The Biochemical journal 2005;388(Pt 3):905-12.
2004: Jens Mogensen; Ross T Murphy; Tony Shaw; Ajay Bahl; Charles Redwood; Hugh Watkins; Margaret Burke; Perry M Elliott; William J McKenna
Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy.
Journal of the American College of Cardiology 2004;44(10):2033-40.
2004: Emily Flashman; Charles Redwood; Johanna C Moolman-Smook; Hugh Watkins
Cardiac myosin binding protein C: its role in physiology and disease.
Circulation research 2004;94(10):1279-89.
2003: Steven B Marston; Charles Redwood
Modulation of thin filament activation by breakdown or isoform switching of thin filament proteins: physiological and pathological implications.
Circulation research 2003;93(12):1170-8.
2003: Sandra Marisa J Oliveira; Javed Ehtisham; Charles Redwood; Ingegerd Ostman-Smith; Edward M Blair; Hugh Watkins
Mutation analysis of AMP-activated protein kinase subunits in inherited cardiomyopathies: implications for kinase function and disease pathogenesis.
Journal of molecular and cellular cardiology 2003;35(10):1251-5.
2003: Edward Blair; Charles Redwood; Hugh Watkins
Ascertainment strategies and genotype:phenotype correlations in hypertrophic cardiomyopathy.
Circulation 2003;108(4):e24-5; author reply e24-5.
2003: Houman Ashrafian; Charles Redwood; Edward Blair; Hugh Watkins
Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion.
Trends in genetics : TIG 2003;19(5):263-8.
2002: Paul Robinson; Mahmooda Mirza; Adam Knott; Hassan Abdulrazzak; Ruth Willott; Steven B Marston; Hugh Watkins; Charles Redwood
Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy.
The Journal of biological chemistry 2002;277(43):40710-6.
2002: Johanna C Moolman-Smook; Emily Flashman; Willem de Lange; Zhili Li; Valerie A Corfield; Charles Redwood; Hugh Watkins
Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations.
Circulation research 2002;91(8):704-11.
2002: David Burton; Hassan Abdulrazzak; Adam Knott; Kathryn Elliott; Charles Redwood; Hugh Watkins; Steven B Marston; Christopher C Ashley
Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.
The Biochemical journal 2002;362(Pt 2):443-51.
2002: Edward Blair; Charles Redwood; Marisa de Jesus Oliveira; Johanna C Moolman-Smook; Paul Brink; Valerie A Corfield; Ingegerd Ostman-Smith; Hugh Watkins
Mutations of the light meromyosin domain of the beta-myosin heavy chain rod in hypertrophic cardiomyopathy.
Circulation research 2002;90(3):263-9.
2001: Edward Blair; Charles Redwood; Houman Ashrafian; M Oliveira; John Broxholme; B Kerr; A Salmon; Ingegerd Ostman-Smith; Hugh Watkins
Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis.
Human molecular genetics 2001;10(11):1215-20.
2000: W Bing; Adam Knott; Charles Redwood; GM Esposito; Ian Purcell; Hugh Watkins; Steven B Marston
Effect of hypertrophic cardiomyopathy mutations in human cardiac muscle alpha -tropomyosin (Asp175Asn and Glu180Gly) on the regulatory properties of human cardiac troponin determined by in vitro motility assay.
Journal of molecular and cellular cardiology 2000;32(8):1489-98.
2000: Kathryn Elliott; Hugh Watkins; Charles Redwood
Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy.
The Journal of biological chemistry 2000;275(29):22069-74.
2000: Charles Redwood; Karin Lohmann; W Bing; GM Esposito; Kathryn Elliott; Hassan Abdulrazzak; Adam Knott; Ian Purcell; Steven B Marston; Hugh Watkins
Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein.
Circulation research 2000;86(11):1146-52.
1999: Charles Redwood; Johanna C Moolman-Smook; Hugh Watkins
Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy.
Cardiovascular research 1999;44(1):20-36.
1998: R J Isaacs; Sally L Davies; M I Sandri; Charles Redwood; N J Wells; Ian D Hickson
Physiological regulation of eukaryotic topoisomerase II.
Biochimica et biophysica acta 1998;1400(1-3):121-37.
1998: Charles Redwood; Sally L Davies; N J Wells; A M Fry; Ian D Hickson
Casein kinase II stabilizes the activity of human topoisomerase IIalpha in a phosphorylation-independent manner.
The Journal of biological chemistry 1998;273(6):3635-42.
1998: Roberto Bottinelli; DA Coviello; Charles Redwood; Maria Antonietta Pellegrino; Barry J Maron; P Spirito; H Watkins; Carlo Reggiani
A mutant tropomyosin that causes hypertrophic cardiomyopathy is expressed in vivo and associated with an increased calcium sensitivity.
Circulation research 1998;82(1):106-15.
1997: W Bing; Charles Redwood; Ian Purcell; GM Esposito; Hugh Watkins; Steven B Marston
Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility.
Biochemical and biophysical research communications 1997;236(3):760-4.
1996: S Jensen; Charles Redwood; J R Jenkins; Anni H Andersen; Ian D Hickson
Human DNA topoisomerases II alpha and II beta can functionally substitute for yeast TOP2 in chromosome segregation and recombination.
Molecular & general genetics : MGG 1996;252(1-2):79-86.
1994: Alexander V Vorotnikov; Nikolai B Gusev; Suming Hua; J H Collins; Charles Redwood; Steven B Marston
Phosphorylation of aorta caldesmon by endogenous proteolytic fragments of protein kinase C.
Journal of muscle research and cell motility 1994;15(1):37-48.
1993: Alexander V Vorotnikov; Nikolai B Gusev; Suming Hua; J H Collins; Charles Redwood; Steven B Marston
Identification of casein kinase II as a major endogeneous caldesmon kinase in sheep aorta smooth muscle.
FEBS letters 1993;334(1):18-22.
1993: PA Huber; Charles Redwood; N D Avent; Michael Tanner; Steven B Marston
Identification of functioning regulatory sites and a new myosin binding site in the C-terminal 288 amino acids of caldesmon expressed from a human clone.
Journal of muscle research and cell motility 1993;14(4):385-91.
1993: Charles Redwood; Steven B Marston; Nikolai B Gusev
The functional effects of mutations Thr673-->Asp and Ser702-->Asp at the Pro-directed kinase phosphorylation sites in the C-terminus of chicken gizzard caldesmon.
FEBS letters 1993;327(1):85-9.
1993: Steven B Marston; Charles Redwood
The essential role of tropomyosin in cooperative regulation of smooth muscle thin filament activity by caldesmon.
The Journal of biological chemistry 1993;268(17):12317-20.
1993: Charles Redwood; Steven B Marston
Binding and regulatory properties of expressed functional domains of chicken gizzard smooth muscle caldesmon.
The Journal of biological chemistry 1993;268(15):10969-76.
1992: Steven B Marston; Charles Redwood
Inhibition of actin-tropomyosin activation of myosin MgATPase activity by the smooth muscle regulatory protein caldesmon.
The Journal of biological chemistry 1992;267(24):16796-800.
1991: Steven B Marston; Charles Redwood
The molecular anatomy of caldesmon.
The Biochemical journal 1991;279 ( Pt 1)():1-16.
1990: Charles Redwood; Steven B Marston; J Bryan; rob cross; J Kendrick-Jones
The functional properties of full length and mutant chicken gizzard smooth muscle caldesmon expressed in Escherichia coli.
FEBS letters 1990;270(1-2):53-6.
1988: Steven B Marston; Charles Redwood; William Lehman
Reversal of caldesmon function by anti-caldesmon antibodies confirms its role in the calcium regulation of vascular smooth muscle thin filaments.
Biochemical and biophysical research communications 1988;155(1):197-202.