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John Reed

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Motti Gerlic; Naran Gombosuren; Maryla Krajewska; Robert C Liddington; Shu-Ichi Matsuzawa; Antonio Postigo; Martina Proell; Shahram Salek-Ardakani; Arnold Satterthwait; Michael Way; Eric Chi-Wang Yu; Michael Croft; Benjamin Faustin; Rachel Flynn; John C Reed
Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.
Ricardo G Correa; Snezana Milutinovic; John C Reed
Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases.
John C Reed; Maurizio Pellecchia
Ironing out cell death mechanisms.

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All Publications

2013: Motti Gerlic; Naran Gombosuren; Maryla Krajewska; Robert C Liddington; Shu-Ichi Matsuzawa; Antonio Postigo; Martina Proell; Shahram Salek-Ardakani; Arnold Satterthwait; Michael Way; Eric Chi-Wang Yu; Michael Croft; Benjamin Faustin; Rachel Flynn; John C Reed
Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(19):7808-13.
2012: Ricardo G Correa; Snezana Milutinovic; John C Reed
Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases.
Bioscience reports 2012;32(6):597-608.
2012: John C Reed; Maurizio Pellecchia
Ironing out cell death mechanisms.
Cell 2012;149(5):963-5.
2012: Renata Sano; Chih-Wen Shu; Stephen W Tait; Craig M Tamble; David D Thomas; Masaya Yamaguchi; Ricardo G Correa; Russell Dahl; Paul W Diaz; Paul B Fisher; Roberta A Gottlieb; Douglas R Green; Michael Hedvat; Ying-Chen Claire Hou; Maryla Krajewska; Shu-Ichi Matsuzawa; Victor Nizet; Giovanni Quarato; John C Reed
Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy.
Genes & development 2012;26(10):1041-54.
2012: Charitha Madiraju; Shu-Ichi Matsuzawa; Tram Ngo; Ian Pass; Michael Cuddy; Paul Diaz; Paulo H Godoi; Eduard A Sergienko; Stefan Vasile; Kate Welsh; John C Reed
TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors.
Journal of biomolecular screening 2012;17(2):163-76.
2011: Chih-Wen Shu; Charitha Madiraju; Dayong Zhai; Kate Welsh; Paul Diaz; Eduard Sergienko; Renata Sano; John C Reed
High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4.
Journal of biomolecular screening 2011;16(2):174-82.
2011: Jun Wei; Bainan Wu; Li Yang; Dayong Zhai; Ziming Zhang; Elisa Barile; Russell Dahl; Rupesh Dash; Paul B Fisher; Shinichi Kitada; William Placzek; John C Reed; Michele F Rega; John L Stebbins; Maurizio Pellecchia
An optically pure apogossypolone derivative as potent pan-active inhibitor of anti-apoptotic bcl-2 family proteins.
Frontiers in oncology 2011;1():28.
2011: Andrea D'Osualdo; Adam Godzik; Roland N Wagner; Christian X Weichenberger; John Wooley; John C Reed
CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.
PloS one 2011;6(11):e27396.
2011: Maryla Krajewska; Steven Banares; Razqallah Hakem; Brian P Head; Yue Hu; Xianshu Huang; Christina L Kress; Tiffany Kyoda; Ricardo Leyva; John C Reed; Juan Rong; Leonardo Salmena; Chia-Hung Sze; Michael J Whalen; Jinsheng Yang; Zerong You; Stan Krajewski
Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.
PloS one 2011;6(9):e24341.
2010: Anton V Cheltsov; Mika Aoyagi; Alexander E Aleshin; Eric Chi-Wang Yu; Taylor Gilliland; Dayong Zhai; Andrey A Bobkov; John C Reed; Robert C Liddington; Ruben Abagyan
Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention.
Journal of medicinal chemistry 2010;53(10):3899-906.
2010: Jane N Winter; Shuli Li; Vikas Aurora; Daina Variakojis; Beverly Nelson; Maryla Krajewska; Lijun Zhang; Thomas M Habermann; Richard I Fisher; William R Macon; Mukesh Chhanabhai; Raymond E Felgar; Eric D Hsi; L Jeffrey Medeiros; James K Weick; Edie A Weller; Ari Melnick; John C Reed; Sandra J Horning; Randy D Gascoyne
Expression of p21 protein predicts clinical outcome in DLBCL patients older than 60 years treated with R-CHOP but not CHOP: a prospective ECOG and Southwest Oncology Group correlative study on E4494.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(8):2435-42.
2010: G Wei Xu; Mohsin Ali; Tabitha E Wood; Derek Wong; Neil Maclean; Xiaoming Wang; Marcela Gronda; Marko Skrtic; Xiaoming Li; Rose Hurren; Xinliang Mao; Meenakshi Venkatesan; Reza Beheshti Zavareh; Troy Ketela; John C Reed; David Rose; Jason Moffat; Robert A Batey; Sirano Dhe-Paganon; Aaron D Schimmer
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Blood 2010;115(11):2251-9.
2010: Bing Z Carter; Duncan H Mak; Wendy D Schober; Erich Koller; Clemencia Pinilla; Lyubomir T Vassilev; John C Reed; Michael Andreeff
Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML.
Blood 2010;115(2):306-14.
2010: Tabitha E Wood; Shadi Dalili; Craig D Simpson; Mahadeo A Sukhai; Rose Hurren; Kika Anyiwe; Xinliang Mao; Fernando Suarez Saiz; Marcela Gronda; Yanina Eberhard; Neil MacLean; Troy Ketela; John C Reed; Jason Moffat; Mark D Minden; Robert A Batey; Aaron D Schimmer
Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands.
Molecular cancer therapeutics 2010;9(1):246-56.
2009: Fernando R Pinacho Crisóstomo; Yongmei Feng; Xuejun Zhu; Kate Welsh; Jing An; John C Reed; Ziwei Huang
Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.
Bioorganic & medicinal chemistry letters 2009;19(22):6413-8.
2009: Andreas Krieg; Ricardo G Correa; Jason B Garrison; Gaëlle Le Negrate; Kate Welsh; Ziwei Huang; Wolfram T Knoefel; John C Reed
XIAP mediates NOD signaling via interaction with RIP2.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14524-9.
2009: Siew Leong Chan; low lieh; Simon Hsu; Sheng Li; Tong Liu; Eugenio Santelli; Gaelle Le Negrate; John C Reed; Virgil L Woods; Jaime Pascual
Molecular mimicry in innate immunity: crystal structure of a bacterial TIR domain.
The Journal of biological chemistry 2009;284(32):21386-92.
2009: Jun Wei; Shinichi Kitada; Michele F Rega; John L Stebbins; Dayong Zhai; Jason Cellitti; Hongbin Yuan; Aras Emdadi; Russell Dahl; Ziming Zhang; Li Yang; John C Reed; Surya De
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Journal of medicinal chemistry 2009;52(14):4511-23.
2009: Marcia I Dawson; Mao Ye; Xihua Cao; Lulu Farhana; Qiong-Ying Hu; Yong Zhao; Li Ping Xu; Alice Kiselyuk; Ricardo G Correa; Li Yang; Tingjun Hou; John C Reed; Pamela Itkin-Ansari; Fred Levine; Michel F Sanner; Joseph A Fontana; Xiao-kun Zhang
Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene.
ChemMedChem 2009;4(7):1106-19.
2009: Maryla Krajewska; Layton H Smith; Juan Rong; Xianshu Huang; Marc L Hyer; Nikolajs Zeps; Barry Iacopetta; Steven P Linke; Allen H Olson; John C Reed; Stan Krajewski
Image analysis algorithms for immunohistochemical assessment of cell death events and fibrosis in tissue sections.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009;57(7):649-63.
2009: Juan M Zapata; David Llobet; Maryla Krajewska; Sophie Lefebvre; Christina L Kress; John C Reed
Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer.
Blood 2009;113(19):4595-603.
2009: Markus Loeffler; Gaelle Le'Negrate; Maryla Krajewska; John C Reed
Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth.
Cancer immunology, immunotherapy : CII 2009;58(5):769-75.
2009: J B Garrison; Temesgen Samuel; John C Reed
TRAF2-binding BIR1 domain of c-IAP2/MALT1 fusion protein is essential for activation of NF-kappaB.
Oncogene 2009;28(13):1584-93.
2009: Jun Wei; Shinichi Kitada; Michele F Rega; Aras Emdadi; Hongbin Yuan; Jason Cellitti; John L Stebbins; Dayong Zhai; Jiazhi Sun; Li Yang; Russell Dahl; Ziming Zhang; Bainan Wu; Si Wang; Tyler A Reed; Hong-Gang Wang; Nicholas Lawrence; Said Sebti; John C Reed; Surya De
Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.
Molecular cancer therapeutics 2009;8(4):904-13.
2009: Benjamin Faustin; Ya Chen; Dayong Zhai; Gaelle Le Negrate; Lydia Lartigue; Arnold Satterthwait; John C Reed
Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3935-40.
2009: Andreas Krieg; Gaëlle Le Negrate; John C Reed
RIP2-beta: a novel alternative mRNA splice variant of the receptor interacting protein kinase RIP2.
Molecular immunology 2009;46(6):1163-70.
2009: INKI KIM; Chih-Wen Shu; Wenjie Xu; Chung-Wai Shiau; Daniel Grant; Stefan Vasile; Nicholas Cosford; John C Reed
Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.
The Journal of biological chemistry 2009;284(3):1593-603.
2009: Jun Wei; Michele F Rega; Shinichi Kitada; Hongbin Yuan; Dayong Zhai; Prabhakar Risbood; Herbert H Seltzman; Charles E Twine; John C Reed; Maurizio Pellecchia
Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists.
Cancer letters 2009;273(1):107-13.
2009: Hideki Hayashi; Michael Cuddy; Vincent Chih-Wen Shu; Kenneth W Yip; Charitha Madiraju; Paul Diaz; Toshifumi Matsuyama; Muneshige Kaibara; Kohtaro Taniyama; Stefan Vasile; Eduard Sergienko; John C Reed
Versatile assays for high throughput screening for activators or inhibitors of intracellular proteases and their cellular regulators.
PloS one 2009;4(10):e7655.
2009: Fred Princen; Emilie Bard; Farah Sheikh; Sharon S Zhang; Jing Wang; Wagner M Zago; Dongmei Wu; Ramon Diaz Trelles; Beatrice Bailly-Maitre; C Ronald Kahn; Yan Chen; John C Reed; Gang Tong; Mark Mercola; Ju Chen; Gen-Sheng Feng
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.
Molecular and cellular biology 2009;29(2):378-88.
2008: Gundula Rohde; Pawel Kermer; John C Reed; Mathias Bähr; Jochen H Weishaupt
Neuron-specific overexpression of the co-chaperone Bcl-2-associated athanogene-1 in superoxide dismutase 1(G93A)-transgenic mice.
Neuroscience 2008;157(4):844-9.
2008: Diego Calzolari; Stefania Bruschi; Laurence Coquin; Jennifer Schofield; Jacob Feala; John C Reed; Andrew D McCulloch; Giovanni Paternostro
Search algorithms as a framework for the optimization of drug combinations.
PLoS computational biology 2008;4(12):e1000249.
2008: INKI KIM; Wenjie Xu; John C Reed
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
Nature reviews. Drug discovery 2008;7(12):1013-30.
2008: Jui-Wen Huang; Ziming Zhang; Bainan Wu; Jason F Cellitti; Xiyun Zhang; Russell Dahl; Chung-Wai Shiau; Kate Welsh; Aras Emdadi; John L Stebbins; John C Reed; Surya De
Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors.
Journal of medicinal chemistry 2008;51(22):7111-8.
2008: William H Bisson; Ziming Zhang; Kate Welsh; Jui-Wen Huang; Jennifer Ryan; John C Reed; Maurizio Pellecchia
Binding properties of the C-terminal domain of VIAF.
Chemical biology & drug design 2008;72(5):331-6.
2008: K W Yip; John C Reed
Bcl-2 family proteins and cancer.
Oncogene 2008;27(50):6398-406.
2008: John C Reed
Apoptosis and cell death. Foreword.
Oncogene 2008;27(48):6192-3.
2008: Gaëlle Le Negrate; Andreas Krieg; Benjamin Faustin; Markus Loeffler; Adam Godzik; Stan Krajewski; John C Reed
ChlaDub1 of Chlamydia trachomatis suppresses NF-kappaB activation and inhibits IkappaBalpha ubiquitination and degradation.
Cellular microbiology 2008;10(9):1879-92.
2008: Markus Loeffler; Gaelle Le'Negrate; Maryla Krajewska; John C Reed
Inhibition of tumor growth using salmonella expressing Fas ligand.
Journal of the National Cancer Institute 2008;100(15):1113-6.
2008: Kenneth W Yip; Paulo H C Godoi; Dayong Zhai; Xochella Garcia; Jason F Cellitti; Michael Cuddy; Motti Gerlic; Ya Chen; Arnold Satterthwait; Stefan Vasile; Eduard Sergienko; John C Reed
A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors.
Journal of biomolecular screening 2008;13(7):665-73.
2008: G Zhou; Tong-xin Xie; M Zhao; Samar A Jasser; Maher N Younes; D Sano; J Lin; Michael E Kupferman; Alfredo A Santillan; Vyomesh Patel; J Silvio Gutkind; A K Ei-Naggar; E D Emberley; P H Watson; S-I Matsuzawa; John C Reed; Jeffrey N Myers
Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity.
Oncogene 2008;27(25):3527-38.
2008: Dayong Zhai; Chaofang Jin; Chung-Wai Shiau; Shinichi Kitada; Arnold C Satterthwait; John C Reed
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
Molecular cancer therapeutics 2008;7(6):1639-46.
2008: Maryla Krajewska; Shinichi Kitada; Jane N Winter; Daina Variakojis; Alan Lichtenstein; Dayong Zhai; Michael Cuddy; Xianshu Huang; Frederic Luciano; Cheryl H Baker; Hoguen Kim; Eunah Shin; Susan Kennedy; Allen H Olson; Andrzej Badzio; Jacek Jassem; Ivo Meinhold-Heerlein; Michael J Duffy; Aaron D Schimmer; Ming Tsao; Ewan Brown; Anne Sawyers; Michael Andreeff; Dan Mercola; Stan Krajewski; John C Reed
Bcl-B expression in human epithelial and nonepithelial malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(10):3011-21.
2008: Chunyan Xu; Wenjie Xu; Amy E Palmer; John C Reed
BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteins.
The Journal of biological chemistry 2008;283(17):11477-84.
2008: Marc L Hyer; Ranxin Shi; Maryla Krajewska; Colin Meyer; Irina Lebedeva; Paul B Fisher; John C Reed
Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer.
Cancer research 2008;68(8):2927-33.
2008: Lorena A Puto; John C Reed
Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation.
Genes & development 2008;22(8):998-1010.
2008: Dayong Zhai; Chaofang Jin; Ziwei Huang; Arnold C Satterthwait; John C Reed
Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1.
The Journal of biological chemistry 2008;283(15):9580-6.
2008: John C Reed
Bcl-2-family proteins and hematologic malignancies: history and future prospects.
Blood 2008;111(7):3322-30.
2008: Gaëlle Le Negrate; Benjamin Faustin; Kate Welsh; Markus Loeffler; Maryla Krajewska; Patty Hasegawa; Sohini Mukherjee; Kim Orth; Stan Krajewski; Adam Godzik; Donald G Guiney; John C Reed
Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):5045-56.
2008: Jan Liman; Lena Faida; Christoph P Dohm; John C Reed; Mathias Bähr; Pawel Kermer
Subcellular distribution affects BAG1 function.
Brain research 2008;1198():21-6.
2008: Yunfei Wen; Vladislav Golubkov; Alex Y Strongin; Wei Jiang; John C Reed
Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation.
The Journal of biological chemistry 2008;283(5):2793-803.
2008: Benjamin Faustin; John C Reed
Sunburned skin activates inflammasomes.
Trends in cell biology 2008;18(1):4-8.
2007: Andrea Dorfleutner; Siera J Talbott; Nicole B Bryan; Kristin N Funya; Stephanie L Rellick; John C Reed; Xianglin Shi; Yon Rojanasakul; Daniel C Flynn; Christian Stehlik
A Shope Fibroma virus PYRIN-only protein modulates the host immune response.
Virus genes 2007;35(3):685-94.
2007: Massimo M Santoro; Temesgen Samuel; Tracy Mitchell; John C Reed; Didier Y R Stainier
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis.
Nature genetics 2007;39(11):1397-402.
2007: Jungyuen Choi; Dayong Zhai; Xin Zhou; Arnold C Satterthwait; John C Reed; Francesca M Marassi
Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid.
Chemical biology & drug design 2007;70(5):383-92.
2007: Markus Loeffler; Gaelle Le'Negrate; Maryla Krajewska; John C Reed
Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12879-83.
2007: Maryla Krajewska; Allen H Olson; Dan Mercola; John C Reed; Stan Krajewski
Claudin-1 immunohistochemistry for distinguishing malignant from benign epithelial lesions of prostate.
The Prostate 2007;67(9):907-10.
2007: Imtiaz A Mawji; Craig D Simpson; Rose Hurren; Marcela Gronda; Moyo A Williams; Jorge Filmus; James Jonkman; Ralph S Da Costa; Brian C Wilson; Michael P Thomas; John C Reed; Gennadi V Glinsky; Aaron D Schimmer
Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation.
Journal of the National Cancer Institute 2007;99(10):811-22.
2007: Frederic Luciano; Maryla Krajewska; Paulina Ortiz-Rubio; Stan Krajewski; Dayong Zhai; Benjamin Faustin; Jean-Marie Bruey; Beatrice Bailly-Maitre; Alan Lichtenstein; Siva Kumar Kolluri; Arnold C Satterthwait; Xiao-kun Zhang; John C Reed
Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma.
Blood 2007;109(9):3849-55.
2007: Toru Fukushima; Shu-ichi Matsuzawa; Christina L Kress; Jean-Marie Bruey; Maryla Krajewska; Sophie Lefebvre; Juan M Zapata; Ze'ev Ronai; John C Reed
Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6371-6.
2007: Jean-Marie Bruey; Nathalie Bruey-Sedano; Frederic Luciano; Dayong Zhai; ruchi bajpai; Chunyan Xu; Christina L Kress; Beatrice Bailly-Maitre; Xiaoqing Li; Andrei Osterman; Shu-ichi Matsuzawa; Alexey V Terskikh; Benjamin Faustin; John C Reed
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.
Cell 2007;129(1):45-56.
2007: Takashi Mukasa; Eugenio Santelli; John C Reed; Jaime Pascual
Preliminary structural studies on the leucine-zipper homology region of the human protein Bap31.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 4):297-9.
2007: Michele F Rega; John C Reed; Surya De
Robust lanthanide-based assays for the detection of anti-apoptotic Bcl-2-family protein antagonists.
Bioorganic chemistry 2007;35(2):113-20.
2007: Benjamin Faustin; Lydia Lartigue; Jean-Marie Bruey; Frederic Luciano; Eduard Sergienko; Beatrice Bailly-Maitre; Niels Volkmann; Dorit Hanein; Isabelle Rouiller; John C Reed
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation.
Molecular cell 2007;25(5):713-24.
2007: Andrea Dorfleutner; Nicole B Bryan; Siera J Talbott; Kristin N Funya; Stephanie L Rellick; John C Reed; Xianglin Shi; Yon Rojanasakul; Daniel C Flynn; Christian Stehlik
Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.
Infection and immunity 2007;75(3):1484-92.
2007: Beatrice Bailly-Maitre; Emilie A Bard-Chapeau; Frederic Luciano; Nathalie M Droin; Jean-Marie Bruey; Benjamin Faustin; Christina L Kress; Juan M Zapata; John C Reed
Mice lacking bi-1 gene show accelerated liver regeneration.
Cancer research 2007;67(4):1442-50.
2007: Shu-ichi Matsuzawa; John C Reed
Yeast and mammalian two-hybrid systems for studying protein-protein interactions.
Methods in molecular biology (Clifton, N.J.) 2007;383():215-25.
2007: Juan M Zapata; Sophie Lefebvre; John C Reed
Targeting TRAfs for therapeutic intervention.
Advances in experimental medicine and biology 2007;597():188-201.
2007: Christina L Kress; Marina Konopleva; Vanesa Martínez-García; Maryla Krajewska; Sophie Lefebvre; Marc L Hyer; Teresa McQueen; Michael Andreeff; John C Reed; Juan M Zapata
Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma.
PloS one 2007;2(6):e559.
2007: Hyung-Ryong Kim; Han-Jung Chae; Michael Thomas; Tadaaki Miyazaki; Anna Monosov; Edward Monosov; Maryla Krajewska; Stan Krajewski; John C Reed
Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(1):188-96.
2007: Mika Aoyagi; Dayong Zhai; Chaofang Jin; Alexander E Aleshin; Boguslaw Stec; John C Reed; Robert C Liddington
Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein.
Protein science : a publication of the Protein Society 2007;16(1):118-24.
2006: Aaron Laine; Ivan Topisirovic; Dayong Zhai; John C Reed; Katherine L B Borden; Ze'ev Ronai
Regulation of p53 localization and activity by Ubc13.
Molecular and cellular biology 2006;26(23):8901-13.
2006: Marina Konopleva; Rooha Contractor; Twee Tsao; Ismael Samudio; Peter P Ruvolo; Shinichi Kitada; Xingming Deng; Dayong Zhai; Yue-Xi Shi; Thomas B Sneed; Monique Verhaegen; Maria S Soengas; Vivian Ruvolo; Teresa McQueen; Wendy D Schober; Julie C Watt; Tilahun Jiffar; Xiaoyang Ling; Frank C Marini; David Harris; Martin Dietrich; Zeev Estrov; James A McCubrey; W Stratford May; John C Reed; Michael Andreeff
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.
Cancer cell 2006;10(5):375-88.
2006: Marc L Hyer; Temesgen Samuel; John C Reed
The FLIP-side of Fas signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):5929-31.
2006: Ryoji Fujii; Changjun Zhu; Yunfei Wen; Hiroyuki Marusawa; Beatrice Bailly-Maitre; Shu-ichi Matsuzawa; Hong Zhang; Youngsoo Kim; C Frank Bennett; Wei Jiang; John C Reed
HBXIP, cellular target of hepatitis B virus oncoprotein, is a regulator of centrosome dynamics and cytokinesis.
Cancer research 2006;66(18):9099-107.
2006: Rhonda Croxton; Lorena A Puto; Ian De Belle; Michael Thomas; Seiji Torii; Farid Hanaii; Michael Cuddy; John C Reed
Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB.
Cancer research 2006;66(18):9026-35.
2006: Sachiko Homma; Masahiro Iwasaki; G Diane Shelton; Eva Engvall; John C Reed; Shinichi Takayama
BAG3 deficiency results in fulminant myopathy and early lethality.
The American journal of pathology 2006;169(3):761-73.
2006: Barbara Becattini; Carsten Culmsee; Marilisa Leone; Dayong Zhai; Xiyun Zhang; Kevin J Crowell; Michele F Rega; Stefan Landshamer; John C Reed; Nikolaus Plesnila; Surya De
Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12602-6.
2006: John C Reed
Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities.
Cell death and differentiation 2006;13(8):1378-86.
2006: John C Reed
Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms.
Nature clinical practice. Oncology 2006;3(7):388-98.
2006: Maryla Krajewska; Bruce C Turner; Ahmed Shabaik; Stan Krajewski; John C Reed
Expression of BAG-1 protein correlates with aggressive behavior of prostate cancers.
The Prostate 2006;66(8):801-10.
2006: Beatrice Bailly-Maitre; Constantino Fondevila; Fady Kaldas; Nathalie M Droin; Frederic Luciano; Jean-Ehrland Ricci; Rhonda Croxton; Maryla Krajewska; Juan M Zapata; Jerzy W Kupiec-Weglinski; Douglas Farmer; John C Reed
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2809-14.
2006: Aaron D Schimmer; Michael P Thomas; Rose Hurren; Marcela Gronda; Maurizio Pellecchia; Gregory R Pond; Marina Konopleva; Debbie Gurfinkel; Imtiaz A Mawji; Ewan Brown; John C Reed
Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors.
Cancer research 2006;66(4):2367-75.
2006: Temesgen Samuel; Kate Welsh; Thomas Lober; Summanuna H Togo; Juan M Zapata; John C Reed
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.
The Journal of biological chemistry 2006;281(2):1080-90.
2006: Christoph P Dohm; Sandra Siedenberg; Jan Liman; Alessandro Esposito; Fred S Wouters; John C Reed; Mathias Bähr; Pawel Kermer
Bax inhibitor-1 protects neurons from oxygen-glucose deprivation.
Journal of molecular neuroscience : MN 2006;29(1):1-8.
2006: Toru Fukushima; Juan M Zapata; Netai C Singha; Michael Thomas; Christina L Kress; Maryla Krajewska; Stan Krajewski; Ze'ev Ronai; John C Reed; Shu-ichi Matsuzawa
Critical function for SIP, a ubiquitin E3 ligase component of the beta-catenin degradation pathway, for thymocyte development and G1 checkpoint.
Immunity 2006;24(1):29-39.
2006: Ruchi M Newman; Prabhakar Salunkhe; Adam Godzik; John C Reed
Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins.
Infection and immunity 2006;74(1):594-601.
2005: Shu-ichi Matsuzawa; Michael Cuddy; Toru Fukushima; John C Reed
Method for targeting protein destruction by using a ubiquitin-independent, proteasome-mediated degradation pathway.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):14982-7.
2005: Eugenio Santelli; Marilisa Leone; Chenlong Li; Toru Fukushima; Nicholas E Preece; Arthur J Olson; Kathryn R Ely; John C Reed; Surya De; Robert C Liddington; Shu-ichi Matsuzawa
Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex.
The Journal of biological chemistry 2005;280(40):34278-87.
2005: Chunyan Xu; Beatrice Bailly-Maitre; John C Reed
Endoplasmic reticulum stress: cell life and death decisions.
The Journal of clinical investigation 2005;115(10):2656-64.
2005: ShuangDing Wu; Ping Xie; Kate Welsh; Chenglong Li; Chao-Zhou Ni; Xiuwen Zhu; John C Reed; Arnold C Satterthwait; Gail A Bishop; Kathryn R Ely
LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3.
The Journal of biological chemistry 2005;280(39):33620-6.
2005: Maryla Krajewska; Hoguen Kim; Eunah Shin; Susan Kennedy; Michael J Duffy; Yick F Wong; David Marr; Jowita Mikolajczyk; Ahmed Shabaik; Ivo Meinhold-Heerlein; Xianshu Huang; Steven Banares; Hirad Hedayat; John C Reed; Stan Krajewski
Tumor-associated alterations in caspase-14 expression in epithelial malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5462-71.
2005: Maryla Krajewska; Hoguen Kim; Chul Kim; Haeyoun Kang; Kate Welsh; Shu-ichi Matsuzawa; Michelle Tsukamoto; Ronald Thomas; Nuria Assa-Munt; Zhe Piao; Koichi Suzuki; Manuel Perucho; Stan Krajewski; John C Reed
Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5451-61.
2005: Marc L Hyer; Rhonda Croxton; Maryla Krajewska; Stan Krajewski; Christina L Kress; Meiling Lu; Nanjoo Suh; Michael B. Sporn; Vincent L Cryns; Juan M Zapata; John C Reed
Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.
Cancer research 2005;65(11):4799-808.
2005: Bing Z Carter; Marcela Gronda; Zhiliang Wang; Kate Welsh; Clemencia Pinilla; Michael Andreeff; Wendy D Schober; Adel Nefzi; Gregory R Pond; Imtiaz A Mawji; Richard A Houghten; John M Ostresh; Joseph Brandwein; Mark D Minden; Andre C Schuh; Richard A Wells; Hans A Messner; Kathy Chun; John C Reed; Aaron D Schimmer
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
Blood 2005;105(10):4043-50.
2005: Jan Liman; Sundar Ganesan; Christoph P Dohm; Stan Krajewski; John C Reed; Mathias Bähr; Fred S Wouters; Pawel Kermer
Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity.
Molecular and cellular biology 2005;25(9):3715-25.
2005: Steven Banares; Karin Zeh; Maryla Krajewska; Pawel Kermer; Helene Baribault; John C Reed; Stan Krajewski
Novel pan-neuronal Cre-transgenic line for conditional ablation of genes in the nervous system.
Genesis (New York, N.Y. : 2000) 2005;42(1):6-16.
2005: Dayong Zhai; Frederic Luciano; Xiuwen Zhu; Bin Guo; Arnold C Satterthwait; John C Reed
Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak.
The Journal of biological chemistry 2005;280(16):15815-24.
2005: Frederic Luciano; Dayong Zhai; Xiuwen Zhu; Beatrice Bailly-Maitre; Jean-Ehrland Ricci; Arnold C Satterthwait; John C Reed
Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL.
The Journal of biological chemistry 2005;280(16):15825-35.
2005: Henry Chan; John C Reed
TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40.
Biochemical and biophysical research communications 2005;328(1):198-205.
2005: Temesgen Samuel; Kazuya Okada; Marc L Hyer; Kate Welsh; Juan M Zapata; John C Reed
cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.
Cancer research 2005;65(1):210-8.
2004: Chao-Zhou Ni; Gagik Oganesyan; Kate Welsh; Xiuwen Zhu; John C Reed; Arnold C Satterthwait; Genhong Cheng; Kathryn R Ely
Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7394-400.
2004: Jean-Marie Bruey; Nathalie Bruey-Sedano; Ruchi Newman; Sharon Chandler; Christian Stehlik; John C Reed
PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.
The Journal of biological chemistry 2004;279(50):51897-907.
2004: Juan M Zapata; Maryla Krajewska; Herbert C Morse; Yongwon Choi; John C Reed
TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16600-5.
2004: Jason S Damiano; Ruchi M Newman; John C Reed
Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6338-45.
2004: Zhiliang Wang; Michael Cuddy; Temesgen Samuel; Kate Welsh; Aaron D Schimmer; Farid Hanaii; Richard A Houghten; Clemencia Pinilla; John C Reed
Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors.
The Journal of biological chemistry 2004;279(46):48168-76.
2004: John C Reed
Apoptosis mechanisms: implications for cancer drug discovery.
Oncology (Williston Park, N.Y.) 2004;18(13 Suppl 10):11-20.
2004: Tadaaki Miyazaki; Min Shen; Daisuke Fujikura; Noriko Tosa; Hyung-Ryong Kim; Shigeyuki Kon; Toshimitsu Uede; John C Reed
Functional role of death-associated protein 3 (DAP3) in anoikis.
The Journal of biological chemistry 2004;279(43):44667-72.
2004: Maryla Krajewska; Robert E Rosenthal; Jowita Mikolajczyk; Henning Stennicke; Thomas Wiesenthal; Juergen Mai; Mikihiko Naito; Guy S Salvesen; John C Reed; Gary Fiskum; Stan Krajewski
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.
Experimental neurology 2004;189(2):261-79.
2004: Christian Stehlik; John C Reed
The PYRIN connection: novel players in innate immunity and inflammation.
The Journal of experimental medicine 2004;200(5):551-8.
2004: Irene M Pedersen; Juan M Zapata; Temesgen Samuel; Fiona L Scott; Guy S Salvesen; Tadashi Honda; Gordon W Gribble; Nanjoo Suh; Michael B. Sporn; Thomas Kipps; John C Reed
Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells.
Blood 2004;104(4):932.
2004: Han-Jung Chae; Hyung-Ryong Kim; Chunyan Xu; Beatrice Bailly-Maitre; Maryla Krajewska; Stan Krajewski; Steven Banares; Janice Cui; Murat Digicaylioglu; Ning Ke; Shinichi Kitada; Edward Monosov; Michael Thomas; Christina L Kress; Jeremy R Babendure; Roger Y Tsien; Stuart A Lipton; John C Reed
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.
Molecular cell 2004;15(3):355-66.
2004: Takehiko Dohi; Kazuya Okada; Fang Xia; Casey E Wilford; Temesgen Samuel; Kate Welsh; Hiroyuki Marusawa; Hua Zou; Robert Armstrong; Shu-ichi Matsuzawa; Guy S Salvesen; John C Reed; Dario C Altieri
An IAP-IAP complex inhibits apoptosis.
The Journal of biological chemistry 2004;279(33):34087-90.
2004: Barbara Becattini; Sina Sareth; Dayong Zhai; Kevin J Crowell; Marilisa Leone; John C Reed; Surya De
Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules.
Chemistry & biology 2004;11(8):1107-17.
2004: Robert Schwarzenbacher; Frank Stenner-Liewen; Heike Liewen; John C Reed; Robert C Liddington
Crystal structure of PqqC from Klebsiella pneumoniae at 2.1 A resolution.
Proteins 2004;56(2):401-3.
2004: Xiao-Min Gong; Jungyuen Choi; Carla M Franzin; Dayong Zhai; John C Reed; Francesca M Marassi
Conformation of membrane-associated proapoptotic tBid.
The Journal of biological chemistry 2004;279(28):28954-60.
2004: Robert Schwarzenbacher; Frank Stenner-Liewen; Heike Liewen; Howard Robinson; Hua Yuan; Ella Bossy-Wetzel; John C Reed; Robert C Liddington
Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis.
The Journal of biological chemistry 2004;279(28):29320-4.
2004: Jason S Damiano; Vasco Oliveira; Kate Welsh; John C Reed
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.
The Biochemical journal 2004;381(Pt 1):213-9.
2004: John C Reed; Kutbuddin S Doctor; Adam Godzik
The domains of apoptosis: a genomics perspective.
Science's STKE : signal transduction knowledge environment 2004;2004(239):re9.
2004: Jason S Damiano; John C Reed
CARD proteins as therapeutic targets in cancer.
Current drug targets 2004;5(4):367-74.
2004: Barbara Becattini; Shinichi Kitada; Marilisa Leone; Edward Monosov; Sharon Chandler; Dayong Zhai; Thomas Kipps; John C Reed; Surya De
Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).
Chemistry & biology 2004;11(3):389-95.
2004: Bingzhen Lin; Siva Kumar Kolluri; Feng Lin; Wen Liu; Young-Hoon Han; Xihua Cao; Marcia I Dawson; John C Reed; Xiao-kun Zhang
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.
Cell 2004;116(4):527-40.
2004: Carla M Franzin; Jungyuen Choi; Dayong Zhai; John C Reed; Francesca M Marassi
Structural studies of apoptosis and ion transport regulatory proteins in membranes.
Magnetic resonance in chemistry : MRC 2004;42(2):172-9.
2004: Tina Cirman; Kristina Oresić; Gabriela Droga Mazovec; Vito Turk; John C Reed; Richard Myers; Guy S Salvesen; Boris Turk
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins.
The Journal of biological chemistry 2004;279(5):3578-87.
2004: Lajos Pusztai; Savitri Krishnamurti; Jorge Perez Cardona; Nour Sneige; Francisco J Esteva; Marina Volchenok; Patricia Breitenfelder; Shu-Wan Kau; Shin Takayama; Stanislaw Krajewski; John C Reed; Robert C Bast; Gabriel N Hortobagyi
Expression of BAG-1 and BcL-2 proteins before and after neoadjuvant chemotherapy of locally advanced breast cancer.
Cancer investigation 2004;22(2):248-56.
2004: Surya De; John C Reed
Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy.
Current pharmaceutical design 2004;10(12):1387-98.
2004: Michael Andreeff; Michele Milella; Bing Z Carter; Yoko Tabe; Maria R Ricciardi; Thomas B Sneed; Peter P Ruvolo; Rooha Contractor; Twee Tsao; Wendy D Schober; Randall Evans; Teresa McQueen; Zhihong Zeng; Steven M Kornblau; James A McCubrey; Elihu Estey; Gordon B Mills; John C Reed; Marina Konopleva
Targeted therapy of AML new concepts.
Annals of hematology 2004;83 Suppl 1():S51-3.
2004: Wilfried Roth; John C Reed
FLIP protein and TRAIL-induced apoptosis.
Vitamins and hormones 2004;67():189-206.
2004: Aaron D Schimmer; Kate Welsh; Clemencia Pinilla; Zhiliang Wang; Maryla Krajewska; Marie-Josee Bonneau; Irene M Pedersen; Shinichi Kitada; Fiona L Scott; Beatrice Bailly-Maitre; Gennadi V Glinsky; Dominic A Scudiero; Edward A Sausville; Guy S Salvesen; Adel Nefzi; John M Ostresh; Richard A Houghten; John C Reed
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Cancer cell 2004;5(1):25-35.
2003: Han-Jung Chae; Ning Ke; Hyung-Ryong Kim; Shaorong Chen; Adam Godzik; Martin Dickman; John C Reed
Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeast.
Gene 2003;323():101-13.
2003: John C Reed; Darcy B Wilson
Cancer immunotherapy targeting survivin: commentary re: V. Pisarev et al., full-length dominant-negative survivin for cancer immunotherapy. Clin. Cancer Res., 9:6523-6533, 2003.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6310-5.
2003: Chenglong Li; Paula S Norris; Chao-Zhou Ni; Marnie Havert Fusco; Elizabeth M Chiong; Bonnie R Tran; Edelmira Cabezas; John C Reed; Arnold C Satterthwait; Carl Ware; Kathryn R Ely
Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling.
The Journal of biological chemistry 2003;278(50):50523-9.
2003: Shinichi Takayama; John C Reed; Sachiko Homma
Heat-shock proteins as regulators of apoptosis.
Oncogene 2003;22(56):9041-7.
2003: Marilisa Leone; Dayong Zhai; Sina Sareth; Shinichi Kitada; John C Reed; Surya De
Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins.
Cancer research 2003;63(23):8118-21.
2003: Christian Stehlik; Sug Hyung Lee; Andrea Dorfleutner; Angela Stassinopoulos; Junji Sagara; John C Reed
Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6154-63.
2003: Bing Z Carter; Steven M Kornblau; Twee Tsao; Rui-Yu Wang; Wendy D Schober; Michele Milella; Hsi-Guang Sung; John C Reed; Michael Andreeff
Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis.
Blood 2003;102(12):4179-86.
2003: Dayong Zhai; Ning Ke; Haichao Zhang; Uri Ladror; Mary Joseph; Andreas Eichinger; Adam Godzik; Shi-Chung Ng; John C Reed
Characterization of the anti-apoptotic mechanism of Bcl-B.
The Biochemical journal 2003;376(Pt 1):229-36.
2003: W-S Suh; Y S Kim; Aaron D Schimmer; Shinichi Kitada; Mark D Minden; Michael Andreeff; Nanjoo Suh; Michael B. Sporn; John C Reed
Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL.
Leukemia 2003;17(11):2122-9.
2003: Maryla Krajewska; Stan Krajewski; Steven Banares; Xianshu Huang; Bruce Turner; Lukas Bubendorf; Olli Kallioniemi; Ahmed Shabaik; Antonella Vitiello; Donna Peehl; Guo-Jian Gao; John C Reed
Elevated expression of inhibitor of apoptosis proteins in prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4914-25.
2003: Pawel Kermer; Murat Digicaylioglu; Marcus Kaul; Juan M Zapata; Maryla Krajewska; Frank Stenner-Liewen; Shinichi Takayama; Stan Krajewski; Stuart A Lipton; John C Reed
BAG1 over-expression in brain protects against stroke.
Brain pathology (Zurich, Switzerland) 2003;13(4):495-506.
2003: Wilfried Roth; Pawel Kermer; Maryla Krajewska; Kate Welsh; S Davis; Stan Krajewski; John C Reed
Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways.
Cell death and differentiation 2003;10(10):1178-87.
2003: Shinichi Kitada; Marilisa Leone; Sina Sareth; Dayong Zhai; John C Reed; Surya De
Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.
Journal of medicinal chemistry 2003;46(20):4259-64.
2003: Taro Kawai; Shizuo Akira; John C Reed
ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
Molecular and cellular biology 2003;23(17):6174-86.
2003: Christian Stehlik; Hideki Hayashi; frederic pio; Adam Godzik; John C Reed
CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways.
The Journal of biological chemistry 2003;278(34):31941-9.
2003: Hwain Shin; Kazuya Okada; John C Wilkinson; Katherine M Solomon; Colin S Duckett; John C Reed; Guy S Salvesen
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein.
The Biochemical journal 2003;373(Pt 3):965-71.
2003: Christian Stehlik; Maryla Krajewska; Kate Welsh; Stan Krajewski; Adam Godzik; John C Reed
The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation.
The Biochemical journal 2003;373(Pt 1):101-13.
2003: Hiroyuki Marusawa; Shu-ichi Matsuzawa; Kate Welsh; Hua Zou; Robert Armstrong; Ingo Tamm; John C Reed
HBXIP functions as a cofactor of survivin in apoptosis suppression.
The EMBO journal 2003;22(11):2729-40.
2003: John C Reed; Kutbuddin Doctor; Ana Rojas; Juan M Zapata; Christian Stehlik; Loredana Fiorentino; Jason S Damiano; Wilfried Roth; Shu-ichi Matsuzawa; Ruchi Newman; Shinichi Takayama; Hiroyuki Marusawa; Famming Xu; Guy S Salvesen; Adam Godzik
Comparative analysis of apoptosis and inflammation genes of mice and humans.
Genome research 2003;13(6B):1376-88.
2003: Kutbuddin Doctor; John C Reed; Adam Godzik; Philip Bourne
The apoptosis database.
Cell death and differentiation 2003;10(6):621-33.
2003: Aaron D Schimmer; Irene Munk-Pedersen; Mark D Minden; John C Reed
Bcl-2 and apoptosis in chronic lymphocytic leukemia.
Current treatment options in oncology 2003;4(3):211-8.
2003: Bin Guo; Dayong Zhai; Edelmira Cabezas; Kate Welsh; Shahrzad Nouraini; Arnold C Satterthwait; John C Reed
Humanin peptide suppresses apoptosis by interfering with Bax activation.
Nature 2003;423(6938):456-61.
2003: Ingo Tamm; Martin Trepel; Marina Cardó-Vila; Yan Sun; Kate Welsh; Edelmira Cabezas; Arnold Swatterthwait; Wadih Arap; John C Reed; Renata Pasqualini
Peptides targeting caspase inhibitors.
The Journal of biological chemistry 2003;278(16):14401-5.
2003: Emel Eksioglu-Demiralp; Shinichi Kitada; Denise Carson; John Garland; Michael Andreef; John C Reed
A method for functional evaluation of caspase activation pathways in intact lymphoid cells using electroporation-mediated protein delivery and flow cytometric analysis.
Journal of immunological methods 2003;275(1-2):41-56.
2003: Aaron D Schimmer; Irene M Pedersen; Shinichi Kitada; Emel Eksioglu-Demiralp; Mark D Minden; Ryan Pinto; Ken Mah; Michael Andreeff; Youngsoo Kim; Won Suk Suh; John C Reed
Functional blocks in caspase activation pathways are common in leukemia and predict patient response to induction chemotherapy.
Cancer research 2003;63(6):1242-8.
2003: Shu-ichi Matsuzawa; Chenglong Li; Chao-Zhou Ni; Shinichi Takayama; John C Reed; Kathryn R Ely
Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP).
The Journal of biological chemistry 2003;278(3):1837-40.
2003: John C Reed
Apoptosis-targeted therapies for cancer.
Cancer cell 2003;3(1):17-22.
2002: Christian Stehlik; Loredana Fiorentino; Andrea Dorfleutner; Jean-Marie Bruey; Eugenia M Ariza; Junji Sagara; John C Reed
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways.
The Journal of experimental medicine 2002;196(12):1605-15.
2002: Stephanie Decary; Julien T Decesse; Vasily Ogryzko; John C Reed; Irina Naguibneva; Annick Harel-Bellan; Chantal E Cremisi
The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2.
Molecular and cellular biology 2002;22(22):7877-88.
2002: Irene M Pedersen; Shinichi Kitada; Aaron D Schimmer; Youngsoo Kim; Juan M Zapata; Lula Charboneau; Laura Rassenti; Michael Andreeff; Frank Bennett; Michael B. Sporn; Lance D Liotta; Thomas Kipps; John C Reed
The triterpenoid CDDO induces apoptosis in refractory CLL B cells.
Blood 2002;100(8):2965-72.
2002: Loredana Fiorentino; Christian Stehlik; Vasco Oliveira; Maria-Eugenia Ariza; Adam Godzik; John C Reed
A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta.
The Journal of biological chemistry 2002;277(38):35333-40.
2002: Irene M Pedersen; Shinichi Kitada; Lorenzo Leoni; Juan M Zapata; James G Karras; Nobuhiro Tsukada; Thomas Kipps; Yong Sung Choi; Frank Bennett; John C Reed
Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.
Blood 2002;100(5):1795-801.
2002: Marina Konopleva; Shourong Zhao; Wei Hu; Shuwei Jiang; Virginia Snell; Douglas Weidner; C Ellen Jackson; Xin Zhang; Richard Champlin; Elihu Estey; John C Reed; Michael Andreeff
The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells.
British journal of haematology 2002;118(2):521-34.
2002: Chao-Zhou Ni; Kate Welsh; Jianhua Zheng; Marnie Havert Fusco; John C Reed; Kathryn R Ely
Crystallization and preliminary X-ray analysis of the TRAF domain of TRAF3.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 8):1340-2.
2002: Sonoko Narisawa; Norman B Hecht; Erwin Goldberg; Kelly M Boatright; John C Reed; José Luis Millán
Testis-specific cytochrome c-null mice produce functional sperm but undergo early testicular atrophy.
Molecular and cellular biology 2002;22(15):5554-62.
2002: Meral Guzey; Shinichi Kitada; John C Reed
Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer.
Molecular cancer therapeutics 2002;1(9):667-77.
2002: Youngsoo Kim; Nanjoo Suh; Michael B. Sporn; John C Reed
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis.
The Journal of biological chemistry 2002;277(25):22320-9.
2002: Can Jin; John C Reed
Yeast and apoptosis.
Nature reviews. Molecular cell biology 2002;3(6):453-9.
2002: Shinichi Kitada; Irene M Pedersen; Aaron D Schimmer; John C Reed
Dysregulation of apoptosis genes in hematopoietic malignancies.
Oncogene 2002;21(21):3459-74.
2002: Pawel Kermer; Maryla Krajewska; Juan M Zapata; S Takayama; Juergen Mai; Stan Krajewski; John C Reed
Bag1 is a regulator and marker of neuronal differentiation.
Cell death and differentiation 2002;9(4):405-13.
2002: Frank Stenner-Liewen; Heike Liewen; Juan M Zapata; Krzysztof Pawlowski; Adam Godzik; John C Reed
CADD, a Chlamydia protein that interacts with death receptors.
The Journal of biological chemistry 2002;277(12):9633-6.
2002: Masafumi Kudoh; Deborah A Knee; Shinichi Takayama; John C Reed
Bag1 proteins regulate growth and survival of ZR-75-1 human breast cancer cells.
Cancer research 2002;62(6):1904-9.
2002: Chenglong Li; Chao-Zhou Ni; Marnie Havert Fusco; Edelmira Cabezas; Jeannie He; Don Kaiser; John C Reed; Arnold C Satterthwait; Genhong Cheng; Kathryn R Ely
Downstream regulator TANK binds to the CD40 recognition site on TRAF3.
Structure (London, England : 1993) 2002;10(3):403-11.
2002: Maryla Krajewska; Juan M Zapata; Ivo Meinhold-Heerlein; Hirad Hedayat; Anne Monks; Hertha Bettendorf; Ahmed Shabaik; Lukas Bubendorf; Olli Kallioniemi; Hoguen Kim; Guido Reifenberger; John C Reed; Stan Krajewski
Expression of Bcl-2 family member Bid in normal and malignant tissues.
Neoplasia (New York, N.Y.) 2002;4(2):129-40.
2002: Wilfried Roth; Frank Stenner-Liewen; Krzysztof Pawlowski; Adam Godzik; John C Reed
Identification and characterization of DEDD2, a death effector domain-containing protein.
The Journal of biological chemistry 2002;277(9):7501-8.
2002: John C Reed; Shinichi Kitada; Youngsoo Kim; John Byrd
Modulating apoptosis pathways in low-grade B-cell malignancies using biological response modifiers.
Seminars in oncology 2002;29(1 Suppl 2):10-24.
2002: Maryla Krajewska; Juergen Mai; Juan M Zapata; Ken W S Ashwell; SL Schendel; John C Reed; Stan Krajewski
Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system.
Cell death and differentiation 2002;9(2):145-57.
2002: John C Reed; Douglas R Green
Remodeling for demolition: changes in mitochondrial ultrastructure during apoptosis.
Molecular cell 2002;9(1):1-3.
2001: Lars Brive; Shinichi Takayama; Klára Briknarová; Sachiko Homma; S K Ishida; John C Reed; Kathryn R Ely
The carboxyl-terminal lobe of Hsc70 ATPase domain is sufficient for binding to BAG1.
Biochemical and biophysical research communications 2001;289(5):1099-105.
2001: N Pathan; C Aime-Sempe; Shinichi Kitada; A Basu; S Haldar; John C Reed
Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1.
Neoplasia (New York, N.Y.) 2001;3(6):550-9.
2001: S Takayama; John C Reed
Molecular chaperone targeting and regulation by BAG family proteins.
Nature cell biology 2001;3(10):E237-41.
2001: John C Reed
The Survivin saga goes in vivo.
The Journal of clinical investigation 2001;108(7):965-9.
2001: S H Lee; Christian Stehlik; John C Reed
Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing.
The Journal of biological chemistry 2001;276(37):34495-500.
2001: N Pathan; Hiroyuki Marusawa; Maryla Krajewska; Shu-ichi Matsuzawa; H Kim; K Okada; S Torii; Shinichi Kitada; Stan Krajewski; Kate Welsh; frederic pio; Adam Godzik; John C Reed
TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.
The Journal of biological chemistry 2001;276(34):32220-9.
2001: M Chen; H He; S Zhan; Stan Krajewski; John C Reed; Roberta Anne Gottlieb
Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion.
The Journal of biological chemistry 2001;276(33):30724-8.
2001: Jason S Damiano; Christian Stehlik; frederic pio; Adam Godzik; John C Reed
CLAN, a novel human CED-4-like gene.
Genomics 2001;75(1-3):77-83.
2001: Juan M Zapata; Krzysztof Pawlowski; E Haas; Carl Ware; Adam Godzik; John C Reed
A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.
The Journal of biological chemistry 2001;276(26):24242-52.
2001: T Miyazaki; John C Reed
A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins.
Nature immunology 2001;2(6):493-500.
2001: Giovanni Paternostro; C Vignola; D U Bartsch; J H Omens; Andrew D McCulloch; John C Reed
Age-associated cardiac dysfunction in Drosophila melanogaster.
Circulation research 2001;88(10):1053-8.
2001: S I Matsuzawa; John C Reed
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
Molecular cell 2001;7(5):915-26.
2001: D A Knee; BA Froesch; U Nuber; Shinichi Takayama; John C Reed
Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity.
The Journal of biological chemistry 2001;276(16):12718-24.
2001: Ning Ke; Adam Godzik; John C Reed
Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak.
The Journal of biological chemistry 2001;276(16):12481-4.
2001: Ivo Meinhold-Heerlein; Frank Stenner-Liewen; Heike Liewen; Shinichi Kitada; Maryla Krajewska; Stan Krajewski; Juan M Zapata; Anne Monks; Dominic A Scudiero; Thomas Bauknecht; John C Reed
Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer.
The American journal of pathology 2001;158(4):1335-44.
2001: Klára Briknarová; Shinichi Takayama; Lars Brive; Marnie Havert Fusco; Deborah A Knee; J Velasco; Sachiko Homma; Edelmira Cabezas; J Stuart; David W Hoyt; Arnold C Satterthwait; Miguel Llinás; John C Reed; Kathryn R Ely
Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein.
Nature structural biology 2001;8(4):349-52.
2001: Z L Chu; frederic pio; Z Xie; Kate Welsh; Maryla Krajewska; Stan Krajewski; Adam Godzik; John C Reed
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis.
The Journal of biological chemistry 2001;276(12):9239-45.
2001: E Leo; Quinn Deveraux; Christian Buchholtz; Kate Welsh; Shu-ichi Matsuzawa; Henning Stennicke; Guy S Salvesen; John C Reed
TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.
The Journal of biological chemistry 2001;276(11):8087-93.
2001: Veronika Stoka; Boris Turk; SL Schendel; T H Kim; Tina Cirman; Scott J Snipas; Lisa M Ellerby; Dale E Bredesen; Hudson H Freeze; M Abrahamson; D Bromme; Stan Krajewski; John C Reed; X M Yin; Vito Turk; Guy S Salvesen
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route.
The Journal of biological chemistry 2001;276(5):3149-57.
2001: Quinn Deveraux; SL Schendel; John C Reed
Antiapoptotic proteins. The bcl-2 and inhibitor of apoptosis protein families.
Cardiology clinics 2001;19(1):57-74.
2001: K Pawłowski; frederic pio; Z Chu; John C Reed; Adam Godzik
PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases.
Trends in biochemical sciences 2001;26(2):85-7.
2001: Bin Guo; Adam Godzik; John C Reed
Bcl-G, a novel pro-apoptotic member of the Bcl-2 family.
The Journal of biological chemistry 2001;276(4):2780-5.
2001: N Pathan; C Aime-Sempe; Shinichi Kitada; S Haldar; John C Reed
Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1.
Neoplasia (New York, N.Y.) 2001;3(1):70-9.
2000: M Guzey; Shinichi Takayama; John C Reed
BAG1L enhances trans-activation function of the vitamin D receptor.
The Journal of biological chemistry 2000;275(52):40749-56.
2000: S Matsuyama; John C Reed
Mitochondria-dependent apoptosis and cellular pH regulation.
Cell death and differentiation 2000;7(12):1155-65.
2000: John C Reed
Mechanisms of apoptosis.
The American journal of pathology 2000;157(5):1415-30.
2000: Juan M Zapata; Maryla Krajewska; Stan Krajewski; Shinichi Kitada; Kate Welsh; Anne Monks; N McCloskey; J Gordon; Thomas Kipps; Randy D Gascoyne; Ahmed Shabaik; John C Reed
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5084-96.
2000: Yurij Ionov; H Yamamoto; Stan Krajewski; John C Reed; Manuel Perucho
Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10872-7.
2000: Chao-Zhou Ni; Kate Welsh; E Leo; C K Chiou; H Wu; John C Reed; Kathryn R Ely
Molecular basis for CD40 signaling mediated by TRAF3.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10395-9.
2000: John C Reed; J R Bischoff
BIRinging chromosomes through cell division--and survivin' the experience.
Cell 2000;102(5):545-8.
2000: Haichao Zhang; Q Huang; Ning Ke; S Matsuyama; B Hammock; Adam Godzik; John C Reed
Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms.
The Journal of biological chemistry 2000;275(35):27303-6.
2000: H Li; Siva Kumar Kolluri; J Gu; Marcia I Dawson; Xihua Cao; Peter D Hobbs; Bingzhen Lin; G Chen; J Lu; Feng Lin; Z Xie; Joseph A Fontana; John C Reed; X Zhang
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.
Science (New York, N.Y.) 2000;289(5482):1159-64.
2000: S Matsuyama; J Llopis; Quinn Deveraux; Roger Y Tsien; John C Reed
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis.
Nature cell biology 2000;2(6):318-25.
2000: Lukasz Jaroszewski; Leszek Rychlewski; John C Reed; Adam Godzik
ATP-activated oligomerization as a mechanism for apoptosis regulation: fold and mechanism prediction for CED-4.
Proteins 2000;39(3):197-203.
2000: K Pawłowski; L Rychlewski; John C Reed; Adam Godzik
From fold to function predictions: an apoptosis regulator protein BID.
Computers & chemistry 2000;24(3-4):511-7.
2000: Ingo Tamm; S M Kornblau; Harry Segall; Stan Krajewski; Kate Welsh; Shinichi Kitada; Dominic A Scudiero; G Tudor; Y H Qui; Anne Monks; Michael Andreeff; John C Reed
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1796-803.
2000: Juan M Zapata; Shu-ichi Matsuzawa; Adam Godzik; E Leo; S A Wasserman; John C Reed
The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity.
The Journal of biological chemistry 2000;275(16):12102-7.
2000: H Zhang; Q Xu; Stan Krajewski; Maryla Krajewska; Z Xie; S Fuess; Shinichi Kitada; Krzysztof Pawlowski; Adam Godzik; John C Reed
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2597-602.
2000: Shahrzad Nouraini; E Six; S Matsuyama; Stan Krajewski; John C Reed
The putative pore-forming domain of Bax regulates mitochondrial localization and interaction with Bcl-X(L).
Molecular and cellular biology 2000;20(5):1604-15.
2000: Xiaodong Wang; Anette Gjörloff-Wingren; M Saxena; N Pathan; John C Reed; Tomas Mustelin
The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1934-9.
2000: Q Xu; Ning Ke; S Matsuyama; John C Reed
Assays for studying Bax-induced lethality in the yeast Saccharomyces cerevisiae.
Methods in enzymology 2000;322():283-96.
2000: S L Schendel; John C Reed
Measuring pore formation by Bcl-2 family proteins.
Methods in enzymology 2000;322():274-82.
2000: Z Xie; John C Reed
Analysis of dimerization of Bcl-2 family proteins by surface plasmon resonance.
Methods in enzymology 2000;322():266-74.
1999: S Matsuyama; Shahrzad Nouraini; John C Reed
Yeast as a tool for apoptosis research.
Current opinion in microbiology 1999;2(6):618-23.
1999: E Leo; Juan M Zapata; John C Reed
CD40-mediated activation of Ig-Cgamma1- and Ig-cepsilon germ-line promoters involves multiple TRAF family proteins.
European journal of immunology 1999;29(12):3908-13.
1999: Quinn Deveraux; Henning Stennicke; Guy S Salvesen; John C Reed
Endogenous inhibitors of caspases.
Journal of clinical immunology 1999;19(6):388-98.
1999: Michael Andreeff; Shuwei Jiang; Xin Zhang; Marina Konopleva; Zeev Estrov; Virginia Snell; Z Xie; M Fatih Okcu; G Sanchez-Williams; J Dong; Elihu H Estey; R C Champlin; Steven M Kornblau; John C Reed; Shourong Zhao
Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid.
Leukemia 1999;13(11):1881-92.
1999: S Torii; D A Egan; R A Evans; John C Reed
Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).
The EMBO journal 1999;18(21):6037-49.
1999: Xin Ye; Patrick Mehlen; Shahrooz Rabizadeh; T VanArsdale; Haichao Zhang; Hwain Shin; JJ Wang; E Leo; Juan M Zapata; Craig A Hauser; John C Reed; Dale E Bredesen
TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.
The Journal of biological chemistry 1999;274(42):30202-8.
1999: Quinn Deveraux; E Leo; Henning Stennicke; Kate Welsh; Guy S Salvesen; John C Reed
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.
The EMBO journal 1999;18(19):5242-51.
1999: Shinichi Kitada; Juan M Zapata; Michael Andreeff; John C Reed
Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia.
British journal of haematology 1999;106(4):995-1004.
1999: E Leo; Kate Welsh; Shu-ichi Matsuzawa; Juan M Zapata; Shinichi Kitada; R S Mitchell; Kathryn R Ely; John C Reed
Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation.
The Journal of biological chemistry 1999;274(32):22414-22.
1999: SL Schendel; Rustam Azimov; Krzysztof Pawlowski; Adam Godzik; Bruce L Kagan; John C Reed
Ion channel activity of the BH3 only Bcl-2 family member, BID.
The Journal of biological chemistry 1999;274(31):21932-6.
1999: John C Reed; Giovanni Paternostro
Postmitochondrial regulation of apoptosis during heart failure.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7614-6.
1999: Stan Krajewski; Maryla Krajewska; Lisa M Ellerby; Kate Welsh; Z Xie; Quinn Deveraux; Guy S Salvesen; Dale E Bredesen; Robert E Rosenthal; Gary Fiskum; John C Reed
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5752-7.
1999: J Gil; H Yamamoto; Juan M Zapata; John C Reed; Manuel Perucho
Impairment of the proapoptotic activity of Bax by missense mutations found in gastrointestinal cancers.
Cancer research 1999;59(9):2034-7.
1999: Hong-Gang Wang; N Pathan; Iryna M Ethell; Stan Krajewski; Yu Yamaguchi; F Shibasaki; Frank McKeon; T Bobo; T F Franke; John C Reed
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
Science (New York, N.Y.) 1999;284(5412):339-43.
1999: Q Xu; JM Jürgensmeier; John C Reed
Methods of assaying Bcl-2 and Bax family proteins in yeast.
Methods (San Diego, Calif.) 1999;17(4):292-304.
1999: Henning Stennicke; Quinn Deveraux; EW Humke; John C Reed; Xiaodong Huang; Guy S Salvesen
Caspase-9 can be activated without proteolytic processing.
The Journal of biological chemistry 1999;274(13):8359-62.
1999: BA Froesch; C Aimé-Sempé; Brian Leber; D Andrews; John C Reed
Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain.
The Journal of biological chemistry 1999;274(10):6469-75.
1999: Stan Krajewski; Maryla Krajewska; Bruce C Turner; C Pratt; B Howard; Juan M Zapata; V Frenkel; S Robertson; Yurij Ionov; H Yamamoto; Manuel Perucho; Shinichi Takayama; John C Reed
Prognostic significance of apoptosis regulators in breast cancer.
Endocrine-related cancer 1999;6(1):29-40.
1999: Quinn Deveraux; John C Reed
IAP family proteins--suppressors of apoptosis.
Genes & development 1999;13(3):239-52.
1999: EA Slee; M T Harte; Ruth M Kluck; BB Wolf; C A Casiano; Donald D Newmeyer; Hong-Gang Wang; John C Reed; D W Nicholson; E S Alnemri; Douglas R Green; Seamus Martin
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.
The Journal of cell biology 1999;144(2):281-92.
1999: Shinichi Takayama; Z Xie; John C Reed
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.
The Journal of biological chemistry 1999;274(2):781-6.
1998: John C Reed
Bcl-2 family proteins.
Oncogene 1998;17(25):3225-36.
1998: Ingo Tamm; Y Wang; Edward A Sausville; Dominic A Scudiero; N Vigna; T Oltersdorf; John C Reed
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.
Cancer research 1998;58(23):5315-20.
1998: DN Bimston; J Song; David P Winchester; Shinichi Takayama; John C Reed; Richard I Morimoto
BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release.
The EMBO journal 1998;17(23):6871-8.
1998: S Matsuyama; S L Schendel; Z Xie; John C Reed
Cytoprotection by Bcl-2 requires the pore-forming alpha5 and alpha6 helices.
The Journal of biological chemistry 1998;273(47):30995-1001.
1998: M H Cardone; N Roy; Henning Stennicke; Guy S Salvesen; T F Franke; E Stanbridge; Steven M Frisch; John C Reed
Regulation of cell death protease caspase-9 by phosphorylation.
Science (New York, N.Y.) 1998;282(5392):1318-21.
1998: Henning Stennicke; JM Jürgensmeier; Hwain Shin; Quinn Deveraux; BB Wolf; X Yang; Qiao Zhou; H Michael Ellerby; Lisa M Ellerby; Dale E Bredesen; Douglas R Green; John C Reed; Christopher J Froelich; Guy S Salvesen
Pro-caspase-3 is a major physiologic target of caspase-8.
The Journal of biological chemistry 1998;273(42):27084-90.
1998: J K Stuart; David G Myszka; Lisa Joss; R S Mitchell; S M McDonald; Z Xie; S Takayama; John C Reed; Kathryn R Ely
Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones.
The Journal of biological chemistry 1998;273(35):22506-14.
1998: John C Reed; J M Jurgensmeier; S Matsuyama
Bcl-2 family proteins and mitochondria.
Biochimica et biophysica acta 1998;1366(1-2):127-37.
1998: Y Li; Bingzhen Lin; A Agadir; R Liu; Marcia I Dawson; John C Reed; Joseph A Fontana; Frédéric Bost; Peter D Hobbs; Y Zheng; Guo-quan Chen; B Shroot; Dan Mercola; Xiao-kun Zhang
Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.
Molecular and cellular biology 1998;18(8):4719-31.
1998: Shinichi Takayama; Stan Krajewski; Maryla Krajewska; Shinichi Kitada; Juan M Zapata; K Kochel; Deborah A Knee; Dominic A Scudiero; G Tudor; G J Miller; T Miyashita; M Yamada; John C Reed
Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.
Cancer research 1998;58(14):3116-31.
1998: R Liu; Shinichi Takayama; Y Zheng; B Froesch; Guo-quan Chen; X Zhang; John C Reed; Xiao-kun Zhang
Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells.
The Journal of biological chemistry 1998;273(27):16985-92.
1998: T Kobayashi; S Ruan; James R Jabbur; U Consoli; Katharina Clodi; Hiroshi Shiku; Laurie B Owen-Schaub; Michael Andreeff; John C Reed; Wei Zhang
Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment.
Cell death and differentiation 1998;5(7):584-91.
1998: John C Reed
Molecular biology of chronic lymphocytic leukemia: implications for therapy.
Seminars in hematology 1998;35(3 Suppl 3):3-13.
1998: Maryla Krajewska; Stan Krajewski; Juan M Zapata; T Van Arsdale; Randy D Gascoyne; K Berern; D McFadden; Ahmed Shabaik; J Hugh; A Reynolds; Charles V Clevenger; John C Reed
TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.
The American journal of pathology 1998;152(6):1549-61.
1998: Shu-ichi Matsuzawa; Shinichi Takayama; B A Froesch; Juan M Zapata; John C Reed
p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.
The EMBO journal 1998;17(10):2736-47.
1998: BA Froesch; Shinichi Takayama; John C Reed
BAG-1L protein enhances androgen receptor function.
The Journal of biological chemistry 1998;273(19):11660-6.
1998: Z Xie; SL Schendel; S Matsuyama; John C Reed
Acidic pH promotes dimerization of Bcl-2 family proteins.
Biochemistry 1998;37(18):6410-8.
1998: Stan Krajewski; A Hugger; Maryla Krajewska; John C Reed; Juergen Mai
Developmental expression patterns of Bcl-2, Bcl-x, Bax, and Bak in teeth.
Cell death and differentiation 1998;5(5):408-15.
1998: SL Schendel; MO Montal; John C Reed
Bcl-2 family proteins as ion-channels.
Cell death and differentiation 1998;5(5):372-80.
1998: Shinichi Kitada; J Andersen; S Akar; Juan M Zapata; S Takayama; Stan Krajewski; Hong-Gang Wang; X Zhang; Florencia Bullrich; C M Croce; Kanti Rai; J Hines; John C Reed
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses.
Blood 1998;91(9):3379-89.
1998: JM Jürgensmeier; Z Xie; Quinn Deveraux; Lisa M Ellerby; Dale E Bredesen; John C Reed
Bax directly induces release of cytochrome c from isolated mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):4997-5002.
1998: Quinn Deveraux; N Roy; Henning Stennicke; T Van Arsdale; Qiao Zhou; S M Srinivasula; E S Alnemri; Guy S Salvesen; John C Reed
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.
The EMBO journal 1998;17(8):2215-23.
1998: R Takahashi; Quinn Deveraux; Ingo Tamm; Kate Welsh; Nuria Assa-Munt; Guy S Salvesen; John C Reed
A single BIR domain of XIAP sufficient for inhibiting caspases.
The Journal of biological chemistry 1998;273(14):7787-90.
1998: John C Reed
Molecular biology of chronic lymphocytic leukemia.
Seminars in oncology 1998;25(1):11-8.
1998: Shinichi Kitada; Maryla Krajewska; X Zhang; Dominic A Scudiero; Juan M Zapata; Hong-Gang Wang; Ahmed Shabaik; G Tudor; Stan Krajewski; Timothy G Myers; G S Johnson; Edward A Sausville; John C Reed
Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines.
The American journal of pathology 1998;152(1):51-61.
1997: Stan Krajewski; Juan M Zapata; Maryla Krajewska; T VanArsdale; Ahmed Shabaik; Randy D Gascoyne; John C Reed
Immunohistochemical analysis of in vivo patterns of TRAF-3 expression, a member of the TNF receptor-associated factor family.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5841-52.
1997: H Zha; John C Reed
Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells.
The Journal of biological chemistry 1997;272(50):31482-8.
1997: N Roy; Quinn Deveraux; R Takahashi; Guy S Salvesen; John C Reed
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.
The EMBO journal 1997;16(23):6914-25.
1997: John C Reed
Cytochrome c: can't live with it--can't live without it.
Cell 1997;91(5):559-62.
1997: John C Reed
Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies.
Seminars in hematology 1997;34(4 Suppl 5):9-19.
1997: PH Vachon; H Xu; L Liu; Frosty Loechel; Y Hayashi; Kiichi Arahata; John C Reed; Ulla M Wewer; Eva Engvall
Integrins (alpha7beta1) in muscle function and survival. Disrupted expression in merosin-deficient congenital muscular dystrophy.
The Journal of clinical investigation 1997;100(7):1870-81.
1997: Shinichi Takayama; DN Bimston; Shu-ichi Matsuzawa; BC Freeman; C Aime-Sempe; Z Xie; Richard I Morimoto; John C Reed
BAG-1 modulates the chaperone activity of Hsp70/Hsc70.
The EMBO journal 1997;16(16):4887-96.
1997: Quinn Deveraux; R Takahashi; Guy S Salvesen; John C Reed
X-linked IAP is a direct inhibitor of cell-death proteases.
Nature 1997;388(6639):300-4.
1997: Stan Krajewski; Randy D Gascoyne; Juan M Zapata; Maryla Krajewska; Shinichi Kitada; Mukesh Chhanabhai; Douglas E Horsman; K Berean; L D Piro; I Fugier-Vivier; Y J Liu; Hong-Gang Wang; John C Reed
Immunolocalization of the ICE/Ced-3-family protease, CPP32 (Caspase-3), in non-Hodgkin's lymphomas, chronic lymphocytic leukemias, and reactive lymph nodes.
Blood 1997;89(10):3817-25.
1997: SL Schendel; Z Xie; M O Montal; S Matsuyama; MO Montal; John C Reed
Channel formation by antiapoptotic protein Bcl-2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5113-8.
1997: Robert W Keane; A Srinivasan; L M Foster; MP Testa; T Ord; D Nonner; Hong-Gang Wang; John C Reed; Dale E Bredesen; C Kayalar
Activation of CPP32 during apoptosis of neurons and astrocytes.
Journal of neuroscience research 1997;48(2):168-80.
1997: Maryla Krajewska; Hong-Gang Wang; Stan Krajewski; Juan M Zapata; Ahmed Shabaik; Randy D Gascoyne; John C Reed
Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease.
Cancer research 1997;57(8):1605-13.
1997: John C Reed; S Orrenius; A F Slater
4th IUBMB conference on 'The Life and Death of the Cell'. Edinburgh 14-17th July 1996.
Cell death and differentiation 1997;4(3):254-8.
1997: Stan Krajewski; Maryla Krajewska; J Ehrmann; M Sikorska; Boleslaw Lach; J Chatten; John C Reed
Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin.
The American journal of pathology 1997;150(3):805-14.
1997: Nicholas Rampino; H Yamamoto; Yurij Ionov; Y Li; H Sawai; John C Reed; Manuel Perucho
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.
Science (New York, N.Y.) 1997;275(5302):967-9.
1997: Stan Krajewski; Ann D Thor; Susan M Edgerton; Dan H Moore; Maryla Krajewska; John C Reed
Analysis of Bax and Bcl-2 expression in p53-immunopositive breast cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(2):199-208.
1997: John C Reed
Bcl-2 family proteins and the hormonal control of cell life and death in normalcy and neoplasia.
Vitamins and hormones 1997;53():99-138.
1996: Hong-Gang Wang; U R Rapp; John C Reed
Bcl-2 targets the protein kinase Raf-1 to mitochondria.
Cell 1996;87(4):629-38.
1996: Maryla Krajewska; C M Fenoglio-Preiser; Stan Krajewski; K Song; J S Macdonald; G Stemmerman; John C Reed
Immunohistochemical analysis of Bcl-2 family proteins in adenocarcinomas of the stomach.
The American journal of pathology 1996;149(5):1449-57.
1996: H Zha; H A Fisk; Michael P Yaffe; Nupam P Mahajan; Brian Herman; John C Reed
Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells.
Molecular and cellular biology 1996;16(11):6494-508.
1996: John C Reed
Mechanisms of Bcl-2 family protein function and dysfunction in health and disease.
Behring Institute Mitteilungen 1996;(97):72-100.
1996: Hong-Gang Wang; S Takayama; U R Rapp; John C Reed
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7063-8.
1996: Stan Krajewski; Maryla Krajewska; John C Reed
Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.
Cancer research 1996;56(12):2849-55.
1996: Maryla Krajewska; Steven F Moss; Stan Krajewski; K Song; Peter R Holt; John C Reed
Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.
Cancer research 1996;56(10):2422-7.
1996: Stan Krajewski; Juan M Zapata; John C Reed
Detection of multiple antigens on western blots.
Analytical biochemistry 1996;236(2):221-8.
1996: Maryla Krajewska; Stan Krajewski; Jonathan I Epstein; Ahmed Shabaik; J Sauvageot; K Song; Shinichi Kitada; John C Reed
Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.
The American journal of pathology 1996;148(5):1567-76.
1996: Zhuohua Zhang; Kristiina Vuori; Hong-Gang Wang; John C Reed; Erkki Ruoslahti
Integrin activation by R-ras.
Cell 1996;85(1):61-9.
1996: H Zha; C Aimé-Sempé; T Sato; John C Reed
Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2.
The Journal of biological chemistry 1996;271(13):7440-4.
1996: M Harigai; T Miyashita; M Hanada; John C Reed
A cis-acting element in the BCL-2 gene controls expression through translational mechanisms.
Oncogene 1996;12(6):1369-74.
1996: Y Liu; M O Lee; Hong-Gang Wang; Y Li; Y Hashimoto; M Klaus; John C Reed; X Zhang
Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells.
Molecular and cellular biology 1996;16(3):1138-49.
1996: Shinichi Kitada; Stan Krajewski; T Miyashita; Maryla Krajewska; John C Reed
Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo.
Oncogene 1996;12(1):187-92.
1996: John C Reed; H Zha; C Aime-Sempe; S Takayama; Hong-Gang Wang
Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death.
Advances in experimental medicine and biology 1996;406():99-112.
1996: John C Reed; T Miyashita; S Takayama; Hong-Gang Wang; T Sato; Stan Krajewski; C Aimé-Sempé; S Bodrug; Shinichi Kitada; M Hanada
BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy.
Journal of cellular biochemistry 1996;60(1):23-32.
1996: John C Reed; T Miyashita; Stan Krajewski; S Takayama; C Aime-Sempe; Shinichi Kitada; T Sato; Hong-Gang Wang; M Harigai; M Hanada; Maryla Krajewska; K Kochel; J Millan; H Kobayashi
Bcl-2 family proteins and the regulation of programmed cell death in leukemia and lymphoma.
Cancer treatment and research 1996;84():31-72.
1995: T Miyashita; Shinichi Kitada; S Krajewski; W A Horne; D Delia; John C Reed
Overexpression of the Bcl-2 protein increases the half-life of p21Bax.
The Journal of biological chemistry 1995;270(44):26049-52.
1995: Seamus Martin; Donald D Newmeyer; S Mathias; D M Farschon; Hong-Gang Wang; John C Reed; Richard Kolesnick; Douglas R Green
Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.
The EMBO journal 1995;14(21):5191-200.
1995: Stan Krajewski; C Blomqvist; Kaarle Franssila; Maryla Krajewska; Veli-Matti Wasenius; E Niskanen; S Nordling; John C Reed
Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.
Cancer research 1995;55(19):4471-8.
1995: Stan Krajewski; Jürgen K Mai; Maryla Krajewska; M Sikorska; M J Mossakowski; John C Reed
Upregulation of bax protein levels in neurons following cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(10):6364-76.
1995: Stan Krajewski; S Bodrug; Maryla Krajewska; Ahmed Shabaik; Randy D Gascoyne; K Berean; John C Reed
Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo.
The American journal of pathology 1995;146(6):1309-19.
1995: M Hanada; C Aimé-Sempé; T Sato; John C Reed
Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.
The Journal of biological chemistry 1995;270(20):11962-9.
1995: Hong-Gang Wang; J A Millan; Adrienne D Cox; Channing J Der; U R Rapp; T Beck; H Zha; John C Reed
R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.
The Journal of cell biology 1995;129(4):1103-14.
1995: T Sato; S Irie; S Kitada; John C Reed
FAP-1: a protein tyrosine phosphatase that associates with Fas.
Science (New York, N.Y.) 1995;268(5209):411-5.
1995: John C Reed
Bcl-2: prevention of apoptosis as a mechanism of drug resistance.
Hematology/oncology clinics of North America 1995;9(2):451-73.
1995: Victor A Tron; S Krajewski; H Klein-Parker; G Li; Vincent C Ho; John C Reed
Immunohistochemical analysis of Bcl-2 protein regulation in cutaneous melanoma.
The American journal of pathology 1995;146(3):643-50.
1995: T Miyashita; John C Reed
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.
Cell 1995;80(2):293-9.
1995: S Takayama; T Sato; S Krajewski; K Kochel; S Irie; J A Millan; John C Reed
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity.
Cell 1995;80(2):279-84.
1995: T Sato; S Irie; John C Reed
A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40.
FEBS letters 1995;358(2):113-8.
1995: S Krajewski; J Chatten; M Hanada; John C Reed
Immunohistochemical analysis of the Bcl-2 oncoprotein in human neuroblastomas. Comparisons with tumor cell differentiation and N-Myc protein.
Laboratory investigation; a journal of technical methods and pathology 1995;72(1):42-54.
1994: Stan Krajewski; Maryla Krajewska; Ahmed Shabaik; T Miyashita; Hong-Gang Wang; John C Reed
Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.
The American journal of pathology 1994;145(6):1323-36.
1994: Stan Krajewski; Maryla Krajewska; Ahmed Shabaik; Hong-Gang Wang; S Irie; L Fong; John C Reed
Immunohistochemical analysis of in vivo patterns of Bcl-X expression.
Cancer research 1994;54(21):5501-7.
1994: Donald D Newmeyer; D M Farschon; John C Reed
Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.
Cell 1994;79(2):353-64.
1994: T Torigoe; J A Millan; S Takayama; R Taichman; T Miyashita; John C Reed
Bcl-2 inhibits T-cell-mediated cytolysis of a leukemia cell line.
Cancer research 1994;54(18):4851-4.
1994: Stan Krajewski; S Bodrug; Randy D Gascoyne; K Berean; Maryla Krajewska; John C Reed
Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes.
The American journal of pathology 1994;145(3):515-25.
1994: T Torigoe; J A Millan; K W Chan; R Taichman; A A Brian; John C Reed; R ] Tachman R [corrected to Taichman
Protein tyrosine kinase p56-Lck regulates lymphocyte function-associated 1 adhesion molecule expression, granule exocytosis, and cytolytic effector function in a cloned T cell.
The Journal of experimental medicine 1994;180(3):1115-27.
1994: M Selvakumaran; John C Reed; Dan A Liebermann; Barbara Hoffman
Progression of the myeloid differentiation program is dominant to transforming growth factor-beta 1-induced apoptosis in M1 myeloid leukemic cells.
Blood 1994;84(4):1036-42.
1994: T Miyashita; M Harigai; M Hanada; John C Reed
Identification of a p53-dependent negative response element in the bcl-2 gene.
Cancer research 1994;54(12):3131-5.
1994: T Miyashita; Stan Krajewski; Maryla Krajewska; Hong-Gang Wang; Hsueh-Kung Lin; Dan A Liebermann; Barbara Hoffman; John C Reed
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.
Oncogene 1994;9(6):1799-805.
1994: M Selvakumaran; Hsueh-Kung Lin; T Miyashita; Hong-Gang Wang; Stan Krajewski; John C Reed; Barbara Hoffman; Dan A Liebermann
Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.
Oncogene 1994;9(6):1791-8.
1994: Noriaki Sakuragi; H Matsuo; George Coukos; E E Furth; M P Bronner; C M VanArsdale; S Krajewsky; John C Reed; Jerome F Strauss
Differentiation-dependent expression of the BCL-2 proto-oncogene in the human trophoblast lineage.
Journal of the Society for Gynecologic Investigation 1994;1(2):164-72.
1994: M Selvakumaran; Hsueh-Kung Lin; R T Sjin; John C Reed; Dan A Liebermann; Barbara Hoffman
The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells.
Molecular and cellular biology 1994;14(4):2352-60.
1994: Charles V Clevenger; T Torigoe; John C Reed
Prolactin induces rapid phosphorylation and activation of prolactin receptor-associated RAF-1 kinase in a T-cell line.
The Journal of biological chemistry 1994;269(8):5559-65.
1994: John C Reed
Bcl-2 and the regulation of programmed cell death.
The Journal of cell biology 1994;124(1-2):1-6.
1994: John C Reed; S Kitada; S Takayama; T Miyashita
Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5 Suppl 1():61-5.
1994: Shinichi Kitada; S Takayama; K De Riel; S Tanaka; John C Reed
Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression.
Antisense research and development 1994;4(2):71-9.
1993: M Hanada; Stan Krajewski; S Tanaka; D Cazals-Hatem; Bernhard Spengler; Robert A Ross; June L Biedler; John C Reed
Regulation of Bcl-2 oncoprotein levels with differentiation of human neuroblastoma cells.
Cancer research 1993;53(20):4978-86.
1993: John C Reed; T Torigoe; B C Turner; I Merida; Glen N Gaulton; H Uri Saragovi; U R Rapp; R Taichman
Protooncogene-encoded protein kinases in interleukin-2 signal transduction.
Seminars in immunology 1993;5(5):327-36.
1993: R Taichman; I Merida; T Torigoe; Glen N Gaulton; John C Reed
Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in interleukin-2-dependent T-cells.
The Journal of biological chemistry 1993;268(27):20031-6.
1993: B C Turner; N K Tonks; U R Rapp; John C Reed
Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5544-8.
1993: John C Reed; S Tanaka
Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression.
Leukemia & lymphoma 1993;10(3):157-63.
1993: S Tanaka; K Saito; John C Reed
Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival.
The Journal of biological chemistry 1993;268(15):10920-6.
1993: G Baffy; T Miyashita; JR Williamson; John C Reed
Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.
The Journal of biological chemistry 1993;268(9):6511-9.
1993: Russell Taichman; T Torigoe; John C Reed
A strategy for constructing inducible expression plasmids for T-lymphocytes.
BioTechniques 1993;14(2):180-2.
1993: T Miyashita; John C Reed
Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line.
Blood 1993;81(1):151-7.
1993: Shinichi Kitada; T Miyashita; S Tanaka; John C Reed
Investigations of antisense oligonucleotides targeted against bcl-2 RNAs.
Antisense research and development 1993;3(2):157-69.
1992: M Katsumata; Richard Siegel; Diane Louie; T Miyashita; Y Tsujimoto; Peter C Nowell; Mark I Greene; John C Reed
Differential effects of Bcl-2 on T and B cells in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11376-80.
1992: H Quill; M P Riley; E A Cho; J E Casnellie; John C Reed; T Torigoe
Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):2887-93.
1992: Russell Taichman; T Torigoe; S Tanaka; T Miyashita; John C Reed
Gene transfer investigations of p56-LCK function in IL-2-dependent T-cell lines: implications for mechanisms of IL-2-signal transduction.
Cytokine 1992;4(6):441-53.
1992: John C Reed; T Miyashita; M Cuddy; D Cho
Regulation of p26-bcl-2 protein levels in human peripheral blood lymphocytes.
Laboratory investigation; a journal of technical methods and pathology 1992;67(4):443-9.
1992: T Miyashita; John C Reed
bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.
Cancer research 1992;52(19):5407-11.
1992: T Torigoe; R O'Connor; Remi Fagard; S Fischer; D Santoli; John C Reed
Interleukin 4 inhibits IL-2-induced proliferation of a human T-leukemia cell line without interfering with p56-LCK kinase activation.
Cytokine 1992;4(5):369-76.
1992: D L Cazals-Hatem; Diane Louie; S Tanaka; John C Reed
Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the Bcl-2 oncoprotein.
Biochimica et biophysica acta 1992;1132(1):109-13.
1992: John C Reed; S Tanaka; M Cuddy; D Cho; J Smith; R Kallen; H Uri Saragovi; T Torigoe
A strategy for generating monoclonal antibodies against recombinant baculovirus-produced proteins: application to the Bcl-2 oncoprotein.
Analytical biochemistry 1992;205(1):70-6.
1992: T Torigoe; R O'Connor; D Santoli; John C Reed
Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines.
Blood 1992;80(3):617-24.
1992: Richard Siegel; M Katsumata; T Miyashita; Diane Louie; Mark I Greene; John C Reed
Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):7003-7.
1992: John C Reed; S Tanaka; M Cuddy
Cell cycle analysis of p26-BCL-2 protein levels in proliferating lymphoma and leukemia cell lines.
Cancer research 1992;52(10):2802-5.
1992: T Torigoe; H Uri Saragovi; John C Reed
Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2674-8.
1992: T Torigoe; R O-Connor; Remi Fagard; S Fischer; D Santoli; John C Reed
Regulation of SRC-family protein tyrosine kinases by interleukins, IL-2, and IL-3.
Leukemia 1992;6 Suppl 3():94S-97S.
1992: S Tanaka; D Louie; J Kant; John C Reed
Application of a PCR-mismatch technique to the BCL-2 gene: detection of point mutations in BCL-2 genes of malignancies with A t(14,18).
Leukemia 1992;6 Suppl 3():15S-19S.
1992: S Tanaka; Diane Louie; J A Kant; John C Reed
Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.
Blood 1992;79(1):229-37.
1991: John C Reed; L Meister; S Tanaka; M Cuddy; S Yum; C Geyer; David Pleasure
Differential expression of bcl2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin.
Cancer research 1991;51(24):6529-38.
1991: Diane Louie; J A Kant; John J S Brooks; John C Reed
Absence of t(14;18) major and minor breakpoints and of Bcl-2 protein overproduction in Reed-Sternberg cells of Hodgkin's disease.
The American journal of pathology 1991;139(6):1231-7.
1991: C K Geyer; Xiaoyun Zhu; Peter C Nowell; John C Reed
A new polymorphic probe on chromosome 6q: p327A (D6S93).
Nucleic acids research 1991;19(20):5799.
1991: John C Reed; H S Talwar; M Cuddy; G Baffy; J Williamson; U R Rapp; Gary J Fisher
Mitochondrial protein p26 BCL2 reduces growth factor requirements of NIH3T3 fibroblasts.
Experimental cell research 1991;195(2):277-83.
1991: John C Reed; S Yum; M P Cuddy; B C Turner; U R Rapp
Differential regulation of the p72-74 RAF-1 kinase in 3T3 fibroblasts expressing ras or src oncogenes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(5):235-43.
1991: S Tanaka; J Kant; John C Reed
G to A polymorphism in the second exon of the BCL2 gene.
Nucleic acids research 1991;19(8):1964.
1991: H Makni; James S Malter; John C Reed; S Nobuhiko; G Lang; D Kioussis; G Trinchieri; Malek Kamoun
Reconstitution of an active surface CD2 by DNA transfer in CD2-CD3+ Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2522-9.
1991: D Makover; M Cuddy; S Yum; K Bradley; J Alpers; V Sukhatme; John C Reed
Phorbol ester-mediated inhibition of growth and regulation of proto-oncogene expression in the human T cell leukemia line JURKAT.
Oncogene 1991;6(3):455-60.
1991: John C Reed; U Rapp; M P Cuddy
Transformed 3T3 cells have reduced levels and altered subcellular distribution of the major PKC substrate protein MARCKS.
Cellular signalling 1991;3(6):569-76.
1990: S Haldar; John C Reed; C Beatty; C M Croce
Role of bcl-2 in growth factor triggered signal transduction.
Cancer research 1990;50(22):7399-401.
1990: John C Reed; Cy A Stein; C Subasinghe; S Haldar; C M Croce; S Yum; J Cohen
Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides.
Cancer research 1990;50(20):6565-70.
1990: John C Reed; S Haldar; C M Croce; M P Cuddy
Complementation by BCL2 and C-HA-RAS oncogenes in malignant transformation of rat embryo fibroblasts.
Molecular and cellular biology 1990;10(8):4370-4.
1990: John C Reed; M Cuddy; S Haldar; C Croce; Peter C Nowell; D Makover; K Bradley
BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3660-4.
1989: John C Reed; S Haldar; M P Cuddy; C Croce; D Makover
Deregulated BCL2 expression enhances growth of a human B cell line.
Oncogene 1989;4(9):1123-7.
1989: John C Reed; Y Tsujimoto; S F Epstein; M Cuddy; T Slabiak; Peter C Nowell; C M Croce
Regulation of bcl-2 gene expression in lymphoid cell lines containing normal #18 or t(14;18) chromosomes.
Oncogene research 1989;4(4):271-82.
1988: John C Reed; M Cuddy; T Slabiak; C M Croce; Peter C Nowell
Oncogenic potential of bcl-2 demonstrated by gene transfer.
Nature 1988;336(6196):259-61.
1988: John C Reed; Michael B Prystowsky; Peter C Nowell
Regulation of gene expression in lectin-stimulated or lymphokine-stimulated T lymphocytes. Effects of cyclosporine.
Transplantation 1988;46(2 Suppl):85S-89S.
1988: James S Malter; John C Reed; Malek Kamoun
Induction and regulation of CD2 mRNA in human lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(9):3233-6.
1988: John C Reed; Peter C Nowell
Soluble inhibitors of T lymphocyte proliferation: tools for dissecting pathways of T cell activation.
Immunologic research 1988;7(2):93-112.
1987: H E Broome; John C Reed; E P Godillot; R G Hoover
Differential promoter utilization by the c-myc gene in mitogen- and interleukin-2-stimulated human lymphocytes.
Molecular and cellular biology 1987;7(8):2988-93.
1987: John C Reed; J D Alpers; P A Scherle; R G Hoover; Peter C Nowell; Michael B Prystowsky
Proto-oncogene expression in cloned T lymphocytes: mitogens and growth factors induce different patterns of expression.
Oncogene 1987;1(2):223-8.
1987: John C Reed; Michael B Prystowsky; J A Kern; J D Alpers; Peter C Nowell; R G Hoover
Regulation of proto-oncogene expression during T lymphocyte activation and proliferation.
Advances in experimental medicine and biology 1987;213():249-62.
1986: John C Reed; A H Abidi; J D Alpers; R G Hoover; R J Robb; Peter C Nowell
Effect of cyclosporin A and dexamethasone on interleukin 2 receptor gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(1):150-4.
1986: John C Reed; J D Alpers; Peter C Nowell; R G Hoover
Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):3982-6.
1985: John C Reed; D E Sabath; R G Hoover; Michael B Prystowsky
Recombinant interleukin 2 regulates levels of c-myc mRNA in a cloned murine T lymphocyte.
Molecular and cellular biology 1985;5(12):3361-8.