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Helena Reijonen

Research Profile

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Type 1 Diabetes Mellitus

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TOP 3
Viveka Oling; Helena Reijonen; Olli Simell; Mikael Knip; Jorma Ilonen
Autoantigen-specific memory CD4+ T cells are prevalent early in progression to Type 1 diabetes.
Xinhui Ge; Eddie A James; Helena Reijonen; William W Kwok
Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.
Viveka Oling; Kelly Geubtner; Jorma Ilonen; Helena Reijonen
A low antigen dose selectively promotes expansion of high-avidity autoreactive T cells with distinct phenotypic characteristics: a study of human autoreactive CD4+T cells specific for GAD65.

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All Publications

2012: Viveka Oling; Helena Reijonen; Olli Simell; Mikael Knip; Jorma Ilonen
Autoantigen-specific memory CD4+ T cells are prevalent early in progression to Type 1 diabetes.
Cellular immunology 2012;273(2):133-9.
2011: Xinhui Ge; Eddie A James; Helena Reijonen; William W Kwok
Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.
Journal of autoimmunity 2011;36(2):155-60.
2010: Viveka Oling; Kelly Geubtner; Jorma Ilonen; Helena Reijonen
A low antigen dose selectively promotes expansion of high-avidity autoreactive T cells with distinct phenotypic characteristics: a study of human autoreactive CD4+T cells specific for GAD65.
Autoimmunity 2010;43(8):573-82.
2010: Arno Hänninen; Merja Soilu-Hänninen; Christiane S Hampe; Angie Deptula; Kelly Geubtner; Jorma Ilonen; Mikael Knip; Helena Reijonen
Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes.
Diabetes/metabolism research and reviews 2010;26(4):271-9.
2006: Junbao Yang; Nancy A Danke; DeAnna Berger; Sandra Reichstetter; Helena Reijonen; Carla J Greenbaum; Catherine Pihoker; Eddie A James; William W Kwok
Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2781-9.
2005: Viveka Oling; Jane Marttila; Jorma Ilonen; William W Kwok; Gerald Nepom; Mikael Knip; Olli Simell; Helena Reijonen
GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.
Journal of autoimmunity 2005;25(3):235-43.
2005: Roberto Mallone; Sharon A Kochik; Helena Reijonen; Bryan Carson; Steven F Ziegler; William W Kwok; Gerald Nepom
Functional avidity directs T-cell fate in autoreactive CD4+ T cells.
Blood 2005;106(8):2798-805.
2004: john gebe; Susan A Masewicz; Sharon A Kochik; Helena Reijonen; Gerald Nepom
Inhibition of altered peptide ligand-mediated antagonism of human GAD65-responsive CD4+ T cells by non-antagonizable T cells.
European journal of immunology 2004;34(12):3337-45.
2004: Helena Reijonen; Roberto Mallone; Anne-Kristin Heninger; Elsa M Laughlin; Sharon A Kochik; Ben A Falk; William W Kwok; Carla J Greenbaum; Gerald Nepom
GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.
Diabetes 2004;53(8):1987-94.
2004: Roberto Mallone; Sharon A Kochik; Elsa M Laughlin; Vivian H Gersuk; Helena Reijonen; William W Kwok; Gerald Nepom
Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.
Diabetes 2004;53(4):971-7.
2003: Helena Reijonen; William W Kwok; Gerald Nepom
Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers.
Annals of the New York Academy of Sciences 2003;1005():82-7.
2003: Samy Mrena; Kaisa Savola; Petri Kulmala; Helena Reijonen; Jorma Ilonen; Hans K Akerblom; Mikael Knip
Genetic modification of risk assessment based on staging of preclinical type 1 diabetes in siblings of affected children.
The Journal of clinical endocrinology and metabolism 2003;88(6):2682-9.
2003: john gebe; Ben A Falk; Kellee A Rock; Sharon A Kochik; Anne-Kristin Heninger; Helena Reijonen; William W Kwok; Gerald Nepom
Low-avidity recognition by CD4+ T cells directed to self-antigens.
European journal of immunology 2003;33(5):1409-17.
2003: Helena Reijonen; William W Kwok
Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes.
Methods (San Diego, Calif.) 2003;29(3):282-8.
2002: Jane H Buckner; Ursula Holzer; Erik J Novak; Helena Reijonen; William W Kwok; Gerald Nepom
Defining antigen-specific responses with human MHC class II tetramers.
The Journal of allergy and clinical immunology 2002;110(2):199-208.
2002: Helena Reijonen; Erik J Novak; Sharon A Kochik; Anne-Kristin Heninger; Andrew W Liu; William W Kwok; Gerald Nepom
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects.
Diabetes 2002;51(5):1375-82.
2002: Gerald Nepom; Jane H Buckner; Erik J Novak; Sandra Reichstetter; Helena Reijonen; john gebe; Rongfang Wang; Eric Swanson; William W Kwok
HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells.
Arthritis and rheumatism 2002;46(1):5-12.
2002: Mikko Laaksonen; Tomi Pastinen; Minna Sjöroos; Satu Kuokkanen; Juhani Ruutiainen; Marja-Liisa Sumelahti; Helena Reijonen; Reijo Salonen; Juhani Wikström; Martin Panelius; Jukka Partanen; Pentti J Tienari; Jorma Ilonen
HLA class II associated risk and protection against multiple sclerosis-a Finnish family study.
Journal of neuroimmunology 2002;122(1-2):140-5.
2000: Helena Reijonen; T L Daniels; A Lernmark; Gerald Nepom
GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.
Diabetes 2000;49(10):1621-6.
2000: Jorma Ilonen; Helena Reijonen; A Green; A Reunanen; Mikael Knip; Olli Simell; Hans K Akerblom
Geographical differences within Finland in the frequency of HLA-DQ genotypes associated with type 1 diabetes susceptibility. The Childhood Diabetes in Finland Study Group.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 2000;27(4):225-30.
2000: Suvi M Virtanen; Esa Läärä; Elina Hyppönen; Helena Reijonen; Leena Räsänen; A Aro; Mikael Knip; Jorma Ilonen; Hans K Akerblom
Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group.
Diabetes 2000;49(6):912-7.
2000: Teija Kimpimäki; Petri Kulmala; Kaisa Savola; Paula Vähäsalo; Helena Reijonen; Jorma Ilonen; Hans K Akerblom; Mikael Knip
Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. Childhood Diabetes in Finland Study Group.
The Journal of clinical endocrinology and metabolism 2000;85(3):1126-32.
2000: Petri Kulmala; Kaisa Savola; Helena Reijonen; Riitta Veijola; Paula Vähäsalo; J Karjalainen; Eva Tuomilehto-Wolf; Jorma Ilonen; Jaakko Tuomilehto; Hans K Akerblom; Mikael Knip
Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children. Childhood Diabetes in Finland Study Group.
Diabetes 2000;49(1):48-58.
1999: Jorma Komulainen; Petri Kulmala; Kaisa Savola; Raisa Lounamaa; Jorma Ilonen; Helena Reijonen; Mikael Knip; Hans K Akerblom
Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group.
Diabetes care 1999;22(12):1950-5.
1999: Helena Reijonen; John Elliott; P van Endert; Gerald Nepom
Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1674-81.
1999: William W Kwok; Helena Reijonen; B A Falk; David M Koelle; Gerald Nepom
Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition.
Human immunology 1999;60(7):619-26.
1999: E Sabbah; Kaisa Savola; Petri Kulmala; Helena Reijonen; Riitta Veijola; Paula Vähäsalo; J Karjalainen; Jorma Ilonen; Hans K Akerblom; Mikael Knip
Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). The Childhood Diabetes in Finland Study Group.
Clinical and experimental immunology 1999;116(1):78-83.
1998: Sergey Nejentsev; S Koskinen; Minna Sjöroos; Helena Reijonen; EI Schwartz; L Kovalchuk; A Sochnev; B Adojaan; Toomas Podar; Mikael Knip; Olli Simell; M Koskenvuo; Hans K Akerblom; Jorma Ilonen
Distribution of insulin-dependent diabetes mellitus (IDDM)-related HLA alleles correlates with the difference in IDDM incidence in four populations of the Eastern Baltic region.
Tissue antigens 1998;52(5):473-7.
1998: Minna Sjöroos; Jorma Ilonen; Helena Reijonen; Timo Lövgren
Time-resolved fluorometry based sandwich hybridisation assay for HLA-DQA1 typing.
Disease markers 1998;14(1):9-19.
1998: Jorma Komulainen; Mikael Knip; E Sabbah; Paula Vähäsalo; Raisa Lounamaa; Hans K Akerblom; Helena Reijonen; Jorma Ilonen
Autoimmune and clinical characteristics of type I diabetes in children with different genetic risk loads defined by HLA-DQB1 alleles. Childhood Diabetes in Finland Study Group.
Clinical science (London, England : 1979) 1998;94(3):263-9.
1998: Tero Saukkonen; Suvi M Virtanen; M Karppinen; Helena Reijonen; Jorma Ilonen; Leena Räsänen; Hans K Akerblom; Erkki Savilahti
Significance of cow's milk protein antibodies as risk factor for childhood IDDM: interactions with dietary cow's milk intake and HLA-DQB1 genotype. Childhood Diabetes in Finland Study Group.
Diabetologia 1998;41(1):72-8.
1997: Sergey Nejentsev; Helena Reijonen; B Adojaan; L Kovalchuk; A Sochnevs; EI Schwartz; Hans K Akerblom; Jorma Ilonen
The effect of HLA-B allele on the IDDM risk defined by DRB1*04 subtypes and DQB1*0302.
Diabetes 1997;46(11):1888-92.
1997: Helena Reijonen; Sergey Nejentsev; J Tuokko; S Koskinen; Eva Tuomilehto-Wolf; Hans K Akerblom; Jorma Ilonen
HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1997;24(5):357-63.
1997: M Hiltunen; Heikki Hyöty; Mikael Knip; Jorma Ilonen; Helena Reijonen; Paula Vähäsalo; Merja Roivainen; M Lonnrot; Pauli Leinikki; Tapani Hovi; Hans K Akerblom
Islet cell antibody seroconversion in children is temporally associated with enterovirus infections. Childhood Diabetes in Finland (DiMe) Study Group.
The Journal of infectious diseases 1997;175(3):554-60.
1997: Flemming Pociot; Riitta Veijola; Jesper Johannesen; PM Hansen; T Lorenzen; Allan E Karlsen; Helena Reijonen; Mikael Knip; Jørn Nerup
Analysis of an interferon-gamma gene (IFNG) polymorphism in Danish and Finnish insulin-dependent diabetes mellitus (IDDM) patients and control subjects. Danish Study Group of Diabetes in Childhood.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(2):87-93.
1997: H K Akerblom; Mikael Knip; Heikki Hyöty; Helena Reijonen; Suvi M Virtanen; E Savilahti; J Ilonen
Interaction of genetic and environmental factors in the pathogenesis of insulin-dependent diabetes mellitus.
Clinica chimica acta; international journal of clinical chemistry 1997;257(2):143-56.
1997: J Tuokko; Helena Reijonen; Jorma Ilonen; K Anttila; Seppo T Nikkari; Timo Möttönen; U Yli-Kerttula; Auli Toivanen
Increase of HLA-DRB1*0408 and -DQB1*0301 in HLA-B27 positive reactive arthritis.
Annals of the rheumatic diseases 1997;56(1):37-40.
1997: Pärt Peterson; H Salmi; Heikki Hyöty; A Miettinen; Jorma Ilonen; Helena Reijonen; Mikael Knip; H K Akerblom; Kai Krohn
Steroid 21-hydroxylase autoantibodies in insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group.
Clinical immunology and immunopathology 1997;82(1):37-42.
1996: Riitta Veijola; Helena Reijonen; Paula Vähäsalo; E Sabbah; Petri Kulmala; Jorma Ilonen; Hans K Akerblom; Mikael Knip
HLA-DQB1-defined genetic susceptibility, beta cell autoimmunity, and metabolic characteristics in familial and nonfamilial insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group.
The Journal of clinical investigation 1996;98(11):2489-95.
1996: A Martikainen; Tero Saukkonen; Petri Kulmala; Helena Reijonen; Jorma Ilonen; K Teramo; P Koskela; Mikael Knip; Hans K Akerblom
Disease-associated antibodies in offspring of mothers with IDDM.
Diabetes 1996;45(12):1706-10.
1996: Markus Halminen; Riitta Veijola; Helena Reijonen; Jorma Ilonen; Hans K Akerblom; Mikael Knip
Effect of polymorphism in the insulin gene region on IDDM susceptibility and insulin secretion. The Childhood Diabetes in Finland (DiMe) Study Group.
European journal of clinical investigation 1996;26(10):847-52.
1996: Jorma Ilonen; Helena Reijonen; E Herva; Minna Sjöroos; A Iitiä; Timo Lövgren; Riitta Veijola; Mikael Knip; Hans K Akerblom
Rapid HLA-DQB1 genotyping for four alleles in the assessment of risk for IDDM in the Finnish population. The Childhood Diabetes in Finland (DiMe) Study Group.
Diabetes care 1996;19(8):795-800.
1996: Riitta Veijola; Mikael Knip; R Puukka; Helena Reijonen; D W Cox; Jorma Ilonen
The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: affected-sib-pair analysis and association studies.
American journal of human genetics 1996;59(2):462-70.
1996: Tero Saukkonen; Erkki Savilahti; Helena Reijonen; Jorma Ilonen; Eva Tuomilehto-Wolf; Hans K Akerblom
Coeliac disease: frequent occurrence after clinical onset of insulin-dependent diabetes mellitus. Childhood Diabetes in Finland Study Group.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(5):464-70.
1996: Outi Vaarala; P Klemetti; Erkki Savilahti; Helena Reijonen; Jorma Ilonen; Hans K Akerblom
Cellular immune response to cow's milk beta-lactoglobulin in patients with newly diagnosed IDDM.
Diabetes 1996;45(2):178-82.
1995: Riitta Veijola; Paula Vähäsalo; Eva Tuomilehto-Wolf; Helena Reijonen; Petri Kulmala; Jorma Ilonen; Hans K Akerblom; Mikael Knip
Human leukocyte antigen identity and DQ risk alleles in autoantibody-positive siblings of children with IDDM are associated with reduced early insulin response. Childhood Diabetes in Finland (DiMe) Study Group.
Diabetes 1995;44(9):1021-8.
1995: Minna Sjöroos; A Iitiä; Jorma Ilonen; Helena Reijonen; Timo Lövgren
Triple-label hybridization assay for type-1 diabetes-related HLA alleles.
BioTechniques 1995;18(5):870-7.
1995: Riitta Veijola; Mikael Knip; Helena Reijonen; Paula Vähäsalo; R Puukka; J Iionen
Effect of genetic risk load defined by HLA-DQB1 polymorphism on clinical characteristics of IDDM in children.
European journal of clinical investigation 1995;25(2):106-12.
1994: Helena Reijonen; Paula Vähäsalo; J Karjalainen; Jorma Ilonen; Hans K Akerblom; Mikael Knip
HLA-DQB1 genotypes and islet cell antibodies in the identification of siblings at risk for insulin-dependent diabetes (IDDM) in Finland. Childhood Diabetes in Finland (DiMe) Study Group.
Journal of autoimmunity 1994;7(5):675-86.
1994: P Parkkonen; Heikki Hyöty; Jorma Ilonen; Helena Reijonen; S Ylä-Herttuala; P Leinikki
Antibody reactivity to an Epstein-Barr virus BERF4-encoded epitope occurring also in Asp-57 region of HLA-DQ8 beta chain. Childhood Diabetes in Finland Study Group.
Clinical and experimental immunology 1994;95(2):287-93.
1994: Helena Reijonen; Jorma Ilonen; Mikael Knip
[The role of genes in the type-1 diabetes].
Duodecim; lääketieteellinen aikakauskirja 1994;110(7):695-706.
1994: Helena Reijonen; Jorma Ilonen; Hans K Akerblom; Mikael Knip; H M Dosch
Multi-locus analysis of HLA class II genes in DR2-positive IDDM haplotypes in Finland. The "Childhood Diabetes in Finland" (DiMe) Study Group.
Tissue antigens 1994;43(1):1-6.
1993: Hans K Akerblom; Erkki Savilahti; Tero Saukkonen; A Paganus; Suvi M Virtanen; K Teramo; Mikael Knip; Jorma Ilonen; Helena Reijonen; J Karjalainen
The case for elimination of cow's milk in early infancy in the prevention of type 1 diabetes: the Finnish experience.
Diabetes/metabolism reviews 1993;9(4):269-78.
1992: Jorma Ilonen; H Merivuori; Helena Reijonen; Mikael Knip; Hans K Akerblom; Flemming Pociot; J Nerup
Tumour necrosis factor-beta gene RFLP alleles in Finnish IDDM haplotypes. The Childhood Diabetes in Finland (DiMe) Study Group.
Scandinavian journal of immunology 1992;36(6):779-83.
1992: Markku Hakala; J Ilonen; Helena Reijonen; Mikael Knip; O Koivisto; H Isomäki
No association between rheumatoid arthritis and insulin dependent diabetes mellitus: an epidemiologic and immunogenetic study.
The Journal of rheumatology 1992;19(6):856-8.
1991: Helena Reijonen; Jorma Ilonen; Mikael Knip; Hans K Akerblom
HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland.
Diabetes 1991;40(12):1640-4.
1991: Helena Reijonen; Jorma Ilonen; Mikael Knip; T Reunala
Insulin-dependent diabetes mellitus associated with dermatitis herpetiformis: evidence for heterogeneity of HLA-associated genes.
Tissue antigens 1991;37(2):94-6.
1991: Jorma Ilonen; Markku Hakala; Helena Reijonen; A Tiilikainen
B27-bearing HLA haplotypes in rheumatoid arthritis: characterization in Finnish patients.
Human immunology 1991;30(1):7-10.
1990: Helena Reijonen; Sylvi Silvennoinen-Kassinen; Jorma Ilonen; Mikael Knip
Lack of association of T cell receptor beta-chain constant region polymorphism with insulin-dependent diabetes mellitus in Finland.
Clinical and experimental immunology 1990;81(3):396-9.
1990: Jorma Ilonen; Helena Reijonen; H Arvilommi; I Jokinen; Timo Möttönen; Pekka Hannonen
HLA-DR antigens and HLA-DQ beta chain polymorphism in susceptibility to rheumatoid arthritis.
Annals of the rheumatic diseases 1990;49(7):494-6.
1990: Helena Reijonen; Jorma Ilonen; Mikael Knip; B Michelsen; Hans K Akerblom
HLA-DQ beta-chain restriction fragment length polymorphism as a risk marker in type 1 (insulin-dependent) diabetes mellitus: a Finnish family study.
Diabetologia 1990;33(6):357-62.