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Jörg Reimann

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U Sandhu; M Cebula; S Behme; P Riemer; C Wodarczyk; D Metzger; Jörg Reimann; R Schirmbeck; Hansjörg Hauser; Dagmar Wirth
Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells.
Andreas Wieland; Petra Riedl; Jörg Reimann; Reinhold Schirmbeck
Silencing an immunodominant epitope of hepatitis B surface antigen reveals an alternative repertoire of CD8 T cell epitopes of this viral antigen.
Thorsten Peters; Johannes M Weiss; Anca Sindrilaru; Honglin Wang; Tsvetelina Oreshkova; Meinhard Wlaschek; Pallab Maity; Jörg Reimann; Karin Scharffetter-Kochanek
Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity.

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2011: U Sandhu; M Cebula; S Behme; P Riemer; C Wodarczyk; D Metzger; Jörg Reimann; R Schirmbeck; Hansjörg Hauser; Dagmar Wirth
Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells.
Nucleic acids research 2011;39(1):e1.
2009: Andreas Wieland; Petra Riedl; Jörg Reimann; Reinhold Schirmbeck
Silencing an immunodominant epitope of hepatitis B surface antigen reveals an alternative repertoire of CD8 T cell epitopes of this viral antigen.
Vaccine 2009;28(1):114-9.
2009: Thorsten Peters; Johannes M Weiss; Anca Sindrilaru; Honglin Wang; Tsvetelina Oreshkova; Meinhard Wlaschek; Pallab Maity; Jörg Reimann; Karin Scharffetter-Kochanek
Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity.
Mechanisms of ageing and development 2009;130(9):564-87.
2009: Petra Riedl; Andreas Wieland; Kasper Lamberth; Soren Buus; Francois Lemonnier; Kurt Reifenberg; Jörg Reimann; Reinhold Schirmbeck
Elimination of immunodominant epitopes from multispecific DNA-based vaccines allows induction of CD8 T cells that have a striking antiviral potential.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):370-80.
2009: Christian Wahl; Ursula Wegenka; Frank Leithäuser; Reinhold Schirmbeck; Jörg Reimann
IL-22-dependent attenuation of T cell-dependent (ConA) hepatitis in herpes virus entry mediator deficiency.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4521-8.
2008: Petra Bochtler; Petra Riedl; Ivan Gomez; Reinhold Schirmbeck; Jörg Reimann
Local accumulation and activation of regulatory Foxp3+ CD4 T(R) cells accompanies the appearance of activated CD8 T cells in the liver.
Hepatology (Baltimore, Md.) 2008;48(6):1954-63.
2008: Christian Wahl; Petra Bochtler; Lieping Chen; Reinhold Schirmbeck; Jörg Reimann
B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses.
Gastroenterology 2008;135(3):980-8.
2008: Reinhold Schirmbeck; Jörg Reimann; Stefan Kochanek; Florian Kreppel
The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vector-encoded transgenic antigens.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(9):1609-16.
2008: Andreas Wieland; Markus Denzel; Erika Schmidt; Stefan Kochanek; Florian Kreppel; Jörg Reimann; Reinhold Schirmbeck
Recombinant complexes of antigen with stress proteins are potent CD8 T-cell-stimulating immunogens.
Journal of molecular medicine (Berlin, Germany) 2008;86(9):1067-79.
2008: Petra Bochtler; Andrea Kröger; Reinhold Schirmbeck; Jörg Reimann
Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1633-43.
2008: Andreas Wortmann; Sabine Vöhringer; Tatjana Engler; Stephanie Corjon; Reinhold Schirmbeck; Jörg Reimann; Stefan Kochanek; Florian Kreppel
Fully detargeted polyethylene glycol-coated adenovirus vectors are potent genetic vaccines and escape from pre-existing anti-adenovirus antibodies.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):154-62.
2007: Andrea Kröger; Anja Stirnweiss; Julia Elisabeth Pulverer; Katjana Klages; Martina Grashoff; Jörg Reimann; Hansjörg Hauser
Tumor suppression by IFN regulatory factor-1 is mediated by transcriptional down-regulation of cyclin D1.
Cancer research 2007;67(7):2972-81.
2007: Christian Wahl; Petra Bochtler; Reinhold Schirmbeck; Jörg Reimann
Type I IFN-producing CD4 Valpha14i NKT cells facilitate priming of IL-10-producing CD8 T cells by hepatocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2083-93.
2007: Ursula Wegenka; Nektarios Dikopoulos; Jörg Reimann; Guido Adler; Christian Wahl
The murine liver is a potential target organ for IL-19, IL-20 and IL-24: Type I Interferons and LPS regulate the expression of IL-20R2.
Journal of hepatology 2007;46(2):257-65.
2006: Petra Bochtler; Christian Wahl; Reinhold Schirmbeck; Jörg Reimann
Functional adaptive CD4 Foxp3 T cells develop in MHC class II-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8307-14.
2006: Reinhold Schirmbeck; Petra Riedl; Mark Kupferschmitt; Ursula Wegenka; Hansjörg Hauser; Jason Rice; Andrea Kröger; Jörg Reimann
Priming protective CD8 T cell immunity by DNA vaccines encoding chimeric, stress protein-capturing tumor-associated antigen.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1534-42.
2006: Frank Leithäuser; Tamara Meinhardt-Krajina; Kerstin Fink; Beate Wotschke; Peter Möller; Jörg Reimann
Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.
The American journal of pathology 2006;168(6):1898-909.
2006: Grzegorz Terszowski; Susanna M Müller; Conrad C Bleul; Carmen Blum; Reinhold Schirmbeck; Jörg Reimann; Louis Du Pasquier; Takashi Amagai; Thomas Boehm; Hans-Reimer Rodewald
Evidence for a functional second thymus in mice.
Science (New York, N.Y.) 2006;312(5771):284-7.
2006: Petra Riedl; Antonio Bertoletti; Ross Lopes; Francois Lemonnier; Jörg Reimann; Reinhold Schirmbeck
Distinct, cross-reactive epitope specificities of CD8 T cell responses are induced by natural hepatitis B surface antigen variants of different hepatitis B virus genotypes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4003-11.
2006: Petra Riedl; Jörg Reimann; Reinhold Schirmbeck
Complexes of DNA vaccines with cationic, antigenic peptides are potent, polyvalent CD8(+) T-cell-stimulating immunogens.
Methods in molecular medicine 2006;127():159-69.
2006: Petra Riedl; Nicolas Fissolo; Jörg Reimann; Reinhold Schirmbeck
A stress protein-facilitated antigen expression system for plasmid DNA vaccines.
Methods in molecular medicine 2006;127():41-53.
2006: Natali Froese; Michael Schwarzer; Ina Niedick; Ursula Frischmann; Mario Köster; Andrea Kröger; Peter P Mueller; Mahtab Nourbakhsh; Bastian Pasche; Jörg Reimann; Peter Staeheli; Hansjörg Hauser
Innate immune responses in NF-kappaB-repressing factor-deficient mice.
Molecular and cellular biology 2006;26(1):293-302.
2005: Reinhold Schirmbeck; Petra Riedl; Nicolas Fissolo; Francois A Lemonnier; Antonio Bertoletti; Jörg Reimann
Translation from cryptic reading frames of DNA vaccines generates an extended repertoire of immunogenic, MHC class I-restricted epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4647-56.
2005: Peter Seizer; Petra Riedl; Jörg Reimann; Reinhold Schirmbeck
Different sources of "help" facilitate the antibody response to hepatitis D virus delta antigen.
Journal of molecular medicine (Berlin, Germany) 2005;83(3):225-34.
2005: Nektarios Dikopoulos; Antonio Bertoletti; Andrea Kröger; Hansjörg Hauser; Reinhold Schirmbeck; Jörg Reimann
Type I IFN negatively regulates CD8+ T cell responses through IL-10-producing CD4+ T regulatory 1 cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):99-109.
2005: Nicolas Fissolo; Petra Riedl; Jörg Reimann; Reinhold Schirmbeck
DNA vaccines prime CD8+ T cell responses to epitopes of viral antigens produced from overlapping reading frames of a single coding sequence.
European journal of immunology 2005;35(1):117-27.
2004: Nektarios Dikopoulos; Petra Riedl; Reinhold Schirmbeck; Jörg Reimann
Novel peptide-based vaccines efficiently prime murine "help"-independent CD8+ T cell responses in the liver.
Hepatology (Baltimore, Md.) 2004;40(2):300-9.
2004: Jörg Reimann; Reinhold Schirmbeck
DNA vaccines expressing antigens with a stress protein-capturing domain display enhanced immunogenicity.
Immunological reviews 2004;199():54-67.
2004: Nektarios Dikopoulos; Ursula Wegenka; Andrea Kröger; Hansjörg Hauser; Reinhold Schirmbeck; Jörg Reimann
Recently primed CD8+ T cells entering the liver induce hepatocytes to interact with naïve CD8+ T cells in the mouse.
Hepatology (Baltimore, Md.) 2004;39(5):1256-66.
2004: Tamara Krajina; Frank Leithäuser; Jörg Reimann
MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitis.
European journal of immunology 2004;34(3):705-14.
2004: Ieva Jomantaite; Nektarios Dikopoulos; Andrea Kröger; Frank Leithäuser; Hansjörg Hauser; Reinhold Schirmbeck; Jörg Reimann
Hepatic dendritic cell subsets in the mouse.
European journal of immunology 2004;34(2):355-65.
2004: Petra Riedl; Jörg Reimann; Reinhold Schirmbeck
Peptides containing antigenic and cationic domains have enhanced, multivalent immunogenicity when bound to DNA vaccines.
Journal of molecular medicine (Berlin, Germany) 2004;82(2):144-52.
2003: Nektarios Dikopoulos; Ieva Jomantaite; Reinhold Schirmbeck; Jörg Reimann
Specific, functional effector/memory CD8+ T cells are found in the liver post-vaccination.
Journal of hepatology 2003;39(6):910-7.
2003: Reinhold Schirmbeck; Nektarios Dikopoulos; Marcin Kwissa; Frank Leithäuser; Kasper Lamberth; Soren Buus; Karl Melber; Jörg Reimann
Breaking tolerance in hepatitis B surface antigen (HBsAg) transgenic mice by vaccination with cross-reactive, natural HBsAg variants.
European journal of immunology 2003;33(12):3342-52.
2003: Reinhold Schirmbeck; Petra Riedl; Rinaldo Zurbriggen; Shizuo Akira; Jörg Reimann
Antigenic epitopes fused to cationic peptide bound to oligonucleotides facilitate Toll-like receptor 9-dependent, but CD4+ T cell help-independent, priming of CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5198-207.
2003: Reinhold Schirmbeck; Wolfgang Böhm; Nicolas Fissolo; Karl Melber; Jörg Reimann
Different immunogenicity of H-2 Kb-restricted epitopes in natural variants of the hepatitis B surface antigen.
European journal of immunology 2003;33(9):2429-38.
2003: Marcin Kwissa; Erik B Lindblad; Reinhold Schirmbeck; Jörg Reimann
Codelivery of a DNA vaccine and a protein vaccine with aluminum phosphate stimulates a potent and multivalent immune response.
Journal of molecular medicine (Berlin, Germany) 2003;81(8):502-10.
2003: Reinhold Schirmbeck; Nicolas Fissolo; Paul Chaplin; Jörg Reimann
Enhanced priming of multispecific, murine CD8+ T cell responses by DNA vaccines expressing stress protein-binding polytope peptides.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1240-6.
2003: Tamara Krajina; Frank Leithäuser; Peter Möller; Zlatko Trobonjaca; Jörg Reimann
Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis.
European journal of immunology 2003;33(4):1073-83.
2003: Detlef Stober; Ieva Jomantaite; Reinhold Schirmbeck; Jörg Reimann
NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2540-8.
2003: Marcin Kwissa; Andrea Kröger; Hansjörg Hauser; Jörg Reimann; Reinhold Schirmbeck
Cytokine-facilitated priming of CD8+ T cell responses by DNA vaccination.
Journal of molecular medicine (Berlin, Germany) 2003;81(2):91-101.
2002: Reinhold Schirmbeck; Jörg Reimann
Alternative processing of endogenous or exogenous antigens extends the immunogenic, H-2 class I-restricted peptide repertoire.
Molecular immunology 2002;39(3-4):249-59.
2002: Petra Riedl; Shereen El-Kholy; Jörg Reimann; Reinhold Schirmbeck
Priming biologically active antibody responses against an isolated, conformational viral epitope by DNA vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1251-60.
2002: Reinhold Schirmbeck; Marcin Kwissa; Nicolas Fissolo; Shereen Elkholy; Petra Riedl; Jörg Reimann
Priming polyvalent immunity by DNA vaccines expressing chimeric antigens with a stress protein-capturing, viral J-domain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1108-10.
2002: Reinhold Schirmbeck; Detlef Stober; Shereen El-Kholy; Petra Riedl; Jörg Reimann
The immunodominant, Ld-restricted T cell response to hepatitis B surface antigen (HBsAg) efficiently suppresses T cell priming to multiple Dd-, Kd-, and Kb-restricted HBsAg epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6253-62.
2002: Petra Riedl; Michael Buschle; Jörg Reimann; Reinhold Schirmbeck
Binding immune-stimulating oligonucleotides to cationic peptides from viral core antigen enhances their potency as adjuvants.
European journal of immunology 2002;32(6):1709-16.
2002: Petra Riedl; Detlef Stober; Claude Oehninger; Karl Melber; Jörg Reimann; Reinhold Schirmbeck
Priming Th1 immunity to viral core particles is facilitated by trace amounts of RNA bound to its arginine-rich domain.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):4951-9.
2002: Zlatko Trobonjaca; Andrea Kröger; Detlef Stober; Frank Leithäuser; Peter Möller; Hansjörg Hauser; Reinhold Schirmbeck; Jörg Reimann
Activating immunity in the liver. II. IFN-beta attenuates NK cell-dependent liver injury triggered by liver NKT cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3763-70.
2002: Detlef Stober; Zlatko Trobonjaca; Jörg Reimann; Reinhold Schirmbeck
Dendritic cells pulsed with exogenous hepatitis B surface antigen particles efficiently present epitopes to MHC class I-restricted cytotoxic T cells.
European journal of immunology 2002;32(4):1099-108.
2002: Frank Leithäuser; Tamara Krajina; Zlatko Trobonjaca; Jörg Reimann
Early events in the pathogenesis of a murine transfer colitis.
Pathobiology : journal of immunopathology, molecular and cellular biology 2002;70(3):156-63.
2002: Shereen El-Kholy; Petra Riedl; Marcin Kwissa; Jörg Reimann; Reinhold Schirmbeck
Selective expression of immunogenic, virus-like particle-derived antibody-binding epitopes.
Intervirology 2002;45(4-6):251-9.
2002: Robert Kammerer; Detlef Stober; Petra Riedl; Claude Oehninger; Reinhold Schirmbeck; Jörg Reimann
Noncovalent association with stress protein facilitates cross-priming of CD8+ T cells to tumor cell antigens by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):108-17.
2001: Eliane N Miyaji; Waldely O Dias; Marcia Gamberini; Vera C Gebara; Rocilda P F Schenkman; J Wild; Petra Riedl; Jörg Reimann; Reinhold Schirmbeck; Luciana C C Leite
PsaA (pneumococcal surface adhesin A) and PspA (pneumococcal surface protein A) DNA vaccines induce humoral and cellular immune responses against Streptococcus pneumoniae.
Vaccine 2001;20(5-6):805-12.
2001: Frank Leithäuser; Zlatko Trobonjaca; Peter Möller; Jörg Reimann
Clustering of colonic lamina propria CD4(+) T cells to subepithelial dendritic cell aggregates precedes the development of colitis in a murine adoptive transfer model.
Laboratory investigation; a journal of technical methods and pathology 2001;81(10):1339-49.
2001: M Hennecke; Marcin Kwissa; K Metzger; André Oumard; Andrea Kröger; R Schirmbeck; Jörg Reimann; Hansjörg Hauser
Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs.
Nucleic acids research 2001;29(16):3327-34.
2001: Zlatko Trobonjaca; Frank Leithäuser; Peter Möller; Reinhold Schirmbeck; Jörg Reimann
Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFN-gamma release by liver NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1413-22.
2001: Detlef Stober; Reinhold Schirmbeck; Jörg Reimann
IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):957-65.
2001: Reinhold Schirmbeck; Sven A König-Merediz; Petra Riedl; Marcin Kwissa; Florian Sack; Matthias Schroff; Claas Junghans; Jörg Reimann; Burghardt Wittig
Priming of immune responses to hepatitis B surface antigen with minimal DNA expression constructs modified with a nuclear localization signal peptide.
Journal of molecular medicine (Berlin, Germany) 2001;79(5-6):343-50.
2001: Frank Leithäuser; Zlatko Trobonjaca; Jörg Reimann; Peter Möller
In situ characterization of genetically targeted (green fluorescent) single cells and their microenvironment in an adoptive host.
The American journal of pathology 2001;158(6):1975-83.
2001: Christine V Whiting; Amanda M Williams; Mogens H Claesson; S Bregenholt; Jörg Reimann; Paul W Bland
Transforming growth factor-beta messenger RNA and protein in murine colitis.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(6):727-38.
2001: Robert Kammerer; Detlef Stober; Bernhard Singer; Björn Obrink; Jörg Reimann
Carcinoembryonic antigen-related cell adhesion molecule 1 on murine dendritic cells is a potent regulator of T cell stimulation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6537-44.
2001: Reinhold Schirmbeck; Jörg Reimann
Revealing the potential of DNA-based vaccination: lessons learned from the hepatitis B virus surface antigen.
Biological chemistry 2001;382(4):543-52.
2001: Zlatko Trobonjaca; Frank Leithäuser; Peter Möller; H Bluethmann; Y Koezuka; H R MacDonald; Jörg Reimann
MHC-II-independent CD4+ T cells induce colitis in immunodeficient RAG-/- hosts.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3804-12.
2001: Reinhold Schirmbeck; X Zheng; M Roggendorf; M Geissler; FV Chisari; Jörg Reimann; M Lu
Targeting murine immune responses to selected T cell- or antibody-defined determinants of the hepatitis B surface antigen by plasmid DNA vaccines encoding chimeric antigen.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1405-13.
2001: Reinhold Schirmbeck; Jörg Reimann
Modulation of gene-gun-mediated Th2 immunity to hepatitis B surface antigen by bacterial CpG motifs or IL-12.
Intervirology 2001;44(2-3):115-23.
2001: Jens Brimnes; Jörg Reimann; M Nissen; Mogens H Claesson
Enteric bacterial antigens activate CD4(+) T cells from scid mice with inflammatory bowel disease.
European journal of immunology 2001;31(1):23-31.
2000: John F Tarlton; Christine V Whiting; D Tunmore; S Bregenholt; Jörg Reimann; Mogens H Claesson; Paul W Bland
The role of up-regulated serine proteases and matrix metalloproteinases in the pathogenesis of a murine model of colitis.
The American journal of pathology 2000;157(6):1927-35.
2000: IE Flesch; Detlef Stober; Reinhold Schirmbeck; Jörg Reimann
Monocyte inflammatory protein-1 alpha facilitates priming of CD8(+) T cell responses to exogenous viral antigen.
International immunology 2000;12(9):1365-70.
2000: Jens Brimnes; Jörg Reimann; Mogens H Claesson
Immunoglobulin leakiness in scid mice with CD4(+) T-cell-induced chronic colitis.
Clinical immunology (Orlando, Fla.) 2000;96(3):222-9.
2000: Marcin Kwissa; v K von Kampen; Rinaldo Zurbriggen; Reinhard Glück; Jörg Reimann; Reinhold Schirmbeck
Efficient vaccination by intradermal or intramuscular inoculation of plasmid DNA expressing hepatitis B surface antigen under desmin promoter/enhancer control.
Vaccine 2000;18(22):2337-44.
2000: Reinhold Schirmbeck; Jens Wild; Detlef Stober; H E Blum; FV Chisari; M Geissler; Jörg Reimann
Ongoing murine T1 or T2 immune responses to the hepatitis B surface antigen are excluded from the liver that expresses transgene-encoded hepatitis B surface antigen.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4235-43.
2000: W Böhm; M Schleef; S Thoma; Reinhold Schirmbeck; Jörg Reimann
DNA-Based Vaccination Primes Tumor-Rejecting T-Cell Responses.
Methods in molecular medicine 2000;29():425-37.
2000: Reinhold Schirmbeck; J von Kampen; K Metzger; Jens Wild; B Grüner; M Schleef; A Kröger; Hansjörg Hauser; Jörg Reimann
DNA-Based Vaccination with Polycistronic Expression Plasmids.
Methods in molecular medicine 2000;29():313-22.
2000: Jörg Reimann; Reinhold Schirmbeck
Modulating specific priming of immune effector functions by DNA-based vaccination strategies.
Developments in biologicals 2000;104():15-24.
2000: Marcin Kwissa; J Unsinger; Reinhold Schirmbeck; Hansjörg Hauser; Jörg Reimann
Polyvalent DNA vaccines with bidirectional promoters.
Journal of molecular medicine (Berlin, Germany) 2000;78(9):495-506.
1999: Jörg Reimann; Reinhold Schirmbeck
Alternative pathways for processing exogenous and endogenous antigens that can generate peptides for MHC class I-restricted presentation.
Immunological reviews 1999;172():131-52.
1999: Jens Wild; M J Grusby; Reinhold Schirmbeck; Jörg Reimann
Priming MHC-I-restricted cytotoxic T lymphocyte responses to exogenous hepatitis B surface antigen is CD4+ T cell dependent.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1880-7.
1999: Reinhold Schirmbeck; Karl Melber; Jörg Reimann
Adjuvants that enhance priming of cytotoxic T cells to a Kb-restricted epitope processed from exogenous but not endogenous hepatitis B surface antigen.
International immunology 1999;11(7):1093-102.
1999: Amanda M Williams; Christine V Whiting; K Bonhagen; Jörg Reimann; S Bregenholt; Mogens H Claesson; Paul W Bland
Tumour necrosis factor-alpha (TNF-alpha) transcription and translation in the CD4+ T cell-transplanted scid mouse model of colitis.
Clinical and experimental immunology 1999;116(3):415-24.
1999: Reinhold Schirmbeck; O Gerstner; Jörg Reimann
Truncated or chimeric endogenous protein antigens gain immunogenicity for B cells by stress protein-facilitated expression.
European journal of immunology 1999;29(5):1740-9.
1999: Mogens H Claesson; S Bregenholt; K Bonhagen; S Thoma; Peter Möller; M J Grusby; Frank Leithäuser; Mogens H Nissen; Jörg Reimann
Colitis-inducing potency of CD4+ T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3702-10.
1999: Reinhold Schirmbeck; Jörg Reimann
Enhancing the immunogenicity of exogenous hepatitis B surface antigen-based vaccines for MHC-I-restricted T cells.
Biological chemistry 1999;380(3):285-91.
1998: Reinhold Schirmbeck; J Wild; Jörg Reimann
Similar as well as distinct MHC class I-binding peptides are generated by exogenous and endogenous processing of hepatitis B virus surface antigen.
European journal of immunology 1998;28(12):4149-61.
1998: S Bregenholt; Jörg Reimann; Mogens H Claesson
Proliferation and apoptosis of lamina propria CD4+ T cells from scid mice with inflammatory bowel disease.
European journal of immunology 1998;28(11):3655-63.
1998: S Bregenholt; Jens Brimnes; Jörg Reimann; Mogens H Claesson
Accumulation of immunoglobulin-containing cells in the gut mucosa and presence of faecal immunoglobulin in severe combined immunodeficient (scid) mice with T cell-induced inflammatory bowel disease (IBD).
Clinical and experimental immunology 1998;114(1):19-25.
1998: Wolfgang Böhm; S Thoma; Frank Leithäuser; Peter Möller; Reinhold Schirmbeck; Jörg Reimann
T cell-mediated, IFN-gamma-facilitated rejection of murine B16 melanomas.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):897-908.
1998: K Bonhagen; S Thoma; Frank Leithäuser; Peter Möller; Jörg Reimann
A pancolitis resembling human ulcerative colitis (UC) is induced by CD4+ TCR alphabeta T cells of athymic origin in histocompatible severe combined immunodeficient (SCID) mice.
Clinical and experimental immunology 1998;112(3):443-52.
1998: S Thoma; K Bonhagen; D Vestweber; A Hamann; Jörg Reimann
Expression of selectin-binding epitopes and cytokines by CD4+ T cells repopulating scid mice with colitis.
European journal of immunology 1998;28(6):1785-97.
1998: Wolfgang Böhm; T Mertens; Reinhold Schirmbeck; Jörg Reimann
Routes of plasmid DNA vaccination that prime murine humoral and cellular immune responses.
Vaccine 1998;16(9-10):949-54.
1998: Jens Wild; B Grüner; K Metzger; A Kuhröber; HP Pudollek; Hansjörg Hauser; Reinhold Schirmbeck; Jörg Reimann
Polyvalent vaccination against hepatitis B surface and core antigen using a dicistronic expression plasmid.
Vaccine 1998;16(4):353-60.
1997: Reinhold Schirmbeck; S Thoma; Jörg Reimann
Processing of exogenous hepatitis B surface antigen particles for Ld-restricted epitope presentation depends on exogenous beta2-microglobulin.
European journal of immunology 1997;27(12):3471-84.
1997: Reinhold Schirmbeck; Wolfgang Böhm; Jörg Reimann
Stress protein (hsp73)-mediated, TAP-independent processing of endogenous, truncated SV40 large T antigen for Db-restricted peptide presentation.
European journal of immunology 1997;27(8):2016-23.
1997: Jörg Reimann; Stefan H E Kaufmann
Alternative antigen processing pathways in anti-infective immunity.
Current opinion in immunology 1997;9(4):462-9.
1997: A Kuhröber; Jens Wild; HP Pudollek; FV Chisari; Jörg Reimann
DNA vaccination with plasmids encoding the intracellular (HBcAg) or secreted (HBeAg) form of the core protein of hepatitis B virus primes T cell responses to two overlapping Kb- and Kd-restricted epitopes.
International immunology 1997;9(8):1203-12.
1997: Wolfgang Böhm; Reinhold Schirmbeck; Jörg Reimann
Targeting an anti-viral CD8+ T cell response to a growing tumor facilitates its rejection.
Cancer immunology, immunotherapy : CII 1997;44(4):230-8.
1996: K Bonhagen; S Thoma; P Bland; S Bregenholt; A Rudolphi; Mogens H Claesson; Jörg Reimann
Cytotoxic reactivity of gut lamina propria CD4+ alpha beta T cells in SCID mice with colitis.
European journal of immunology 1996;26(12):3074-83.
1996: Reinhold Schirmbeck; Jörg Reimann
'Empty' Ld molecules capture peptides from endocytosed hepatitis B surface antigen particles for major histocompatibility complex class I-restricted presentation.
European journal of immunology 1996;26(12):2812-22.
1996: Reinhold Schirmbeck; Wolfgang Böhm; Jörg Reimann
DNA vaccination primes MHC class I-restricted, simian virus 40 large tumor antigen-specific CTL in H-2d mice that reject syngeneic tumors.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3550-8.
1996: Wolfgang Böhm; A Kuhröber; T Paier; Thomas Mertens; Jörg Reimann; Reinhold Schirmbeck
DNA vector constructs that prime hepatitis B surface antigen-specific cytotoxic T lymphocyte and antibody responses in mice after intramuscular injection.
Journal of immunological methods 1996;193(1):29-40.
1996: Mogens H Claesson; A Rudolphi; S Kofoed; S S Poulsen; Jörg Reimann
CD4+ T lymphocytes injected into severe combined immunodeficient (SCID) mice lead to an inflammatory and lethal bowel disease.
Clinical and experimental immunology 1996;104(3):491-500.
1996: Andreas Essig; A Rudolphi; M Heinemann; H Rosenthal; R Kaufmann; Jörg Reimann; Reinhard Marre
A model of genital Chlamydia trachomatis infection using human xenografts in severe combined immunodeficiency mice.
Infection and immunity 1996;64(6):2300-7.
1996: R Wagner; Ludwig Deml; Reinhold Schirmbeck; Matthias Niedrig; Jörg Reimann; Hans Wolf
Construction, expression, and immunogenicity of chimeric HIV-1 virus-like particles.
Virology 1996;220(1):128-40.
1996: A Kuhöber; H P Pudollek; Kurt Reifenberg; FV Chisari; Hans-Jürgen Schlicht; Jörg Reimann; Reinhold Schirmbeck
DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(10):3687-95.
1996: A Rudolphi; K Bonhagen; Jörg Reimann
Polyclonal expansion of adoptively transferred CD4+ alpha beta T cells in the colonic lamina propria of scid mice with colitis.
European journal of immunology 1996;26(5):1156-63.
1996: G Boll; Jörg Reimann
Oestrogen treatment depletes extrathymic T cells from intestinal lymphoid tissues.
Scandinavian journal of immunology 1996;43(3):345-50.
1996: Reinhold Schirmbeck; Wolfgang Böhm; Jörg Reimann
Virus-like particles induce MHC class I-restricted T-cell responses. Lessons learned from the hepatitis B small surface antigen.
Intervirology 1996;39(1-2):111-9.
1996: R Wagner; Ludwig Deml; Frank Notka; Hans Wolf; Reinhold Schirmbeck; Jörg Reimann; Vera J P Teeuwsen; Jonathan Luke Heeney
Safety and immunogenicity of recombinant human immunodeficiency virus-like particles in rodents and rhesus macaques.
Intervirology 1996;39(1-2):93-103.
1995: Reinhold Schirmbeck; Wolfgang Böhm; K Melber; Jörg Reimann
Processing of exogenous heat-aggregated (denatured) and particulate (native) hepatitis B surface antigen for class I-restricted epitope presentation.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4676-84.
1995: Reinhold Schirmbeck; Wolfgang Böhm; K Ando; FV Chisari; Jörg Reimann
Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in nonresponder mice.
Journal of virology 1995;69(10):5929-34.
1995: Wolfgang Böhm; Reinhold Schirmbeck; A Elbe; K Melber; D Diminky; G Kraal; N van Rooijen; Y Barenholz; Jörg Reimann
Exogenous hepatitis B surface antigen particles processed by dendritic cells or macrophages prime murine MHC class I-restricted cytotoxic T lymphocytes in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3313-21.
1995: G Boll; Jörg Reimann
Lamina propria T cell subsets in the small and large intestine of euthymic and athymic mice.
Scandinavian journal of immunology 1995;42(2):191-201.
1995: Jörg Reimann; A Rudolphi; S Spiess; Mogens H Claesson
A gut-homing, oligoclonal CD4+ T cell population in severe-combined immunodeficient mice expressing a rearranged, transgenic class I-restricted alpha beta T cell receptor.
European journal of immunology 1995;25(6):1643-53.
1995: Jörg Reimann; A Rudolphi
Co-expression of CD8 alpha in CD4+ T cell receptor alpha beta + T cells migrating into the murine small intestine epithelial layer.
European journal of immunology 1995;25(6):1580-8.
1995: Reinhold Schirmbeck; Ludwig Deml; K Melber; Hans Wolf; R Wagner; Jörg Reimann
Priming of class I-restricted cytotoxic T lymphocytes by vaccination with recombinant protein antigens.
Vaccine 1995;13(9):857-65.
1995: Reinhold Schirmbeck; K Melber; Jörg Reimann
Hepatitis B virus small surface antigen particles are processed in a novel endosomal pathway for major histocompatibility complex class I-restricted epitope presentation.
European journal of immunology 1995;25(4):1063-70.
1995: Jörg Reimann; A Rudolphi; Mogens H Claesson
Novel experimental approaches in the study of the immunopathology in inflammatory bowel disease.
Journal of molecular medicine (Berlin, Germany) 1995;73(3):133-40.
1995: G Boll; A Rudolphi; S Spiess; Jörg Reimann
Regional specialization of intraepithelial T cells in the murine small and large intestine.
Scandinavian journal of immunology 1995;41(2):103-13.
1994: R Wagner; Ludwig Deml; Reinhold Schirmbeck; Jörg Reimann; Hans Wolf
Induction of a MHC class I-restricted, CD8 positive cytolytic T-cell response by chimeric HIV-1 virus-like particles in vivo: implications on HIV vaccine development.
Behring Institute Mitteilungen 1994;(95):23-34.
1994: Reinhold Schirmbeck; Jörg Reimann
Targeting of exogenous protein antigens to a novel endosomal processing pathway for class I-restricted presentation.
Behring Institute Mitteilungen 1994;(95):14-22.
1994: A Kuhröber; Reinhold Schirmbeck; Jörg Reimann
A self-reactive class I-restricted T-cell response of H-2b mice to determinants of the V beta 8.2 domain of the T-cell receptor for antigen.
Immunology 1994;83(4):532-9.
1994: A Rudolphi; G Boll; S S Poulsen; Mogens H Claesson; Jörg Reimann
Gut-homing CD4+ T cell receptor alpha beta+ T cells in the pathogenesis of murine inflammatory bowel disease.
European journal of immunology 1994;24(11):2803-12.
1994: Jörg Reimann; Wolfgang Böhm; Reinhold Schirmbeck
Alternative processing pathways for MHC class I-restricted epitope presentation to CD8+ cytotoxic T lymphocytes.
Biological chemistry Hoppe-Seyler 1994;375(11):731-6.
1994: G Weidt; O Utermöhlen; J Zerrahn; Jörg Reimann; Wolfgang Deppert; F Lehmann-Grube
CD8+ T lymphocyte-mediated antiviral immunity in mice as a result of injection of recombinant viral proteins.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2554-61.
1994: Reinhold Schirmbeck; Wolfgang Böhm; Jörg Reimann
Injection of detergent-denatured ovalbumin primes murine class I-restricted cytotoxic T cells in vivo.
European journal of immunology 1994;24(9):2068-72.
1994: Reinhold Schirmbeck; Jörg Reimann
Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation.
European journal of immunology 1994;24(7):1478-86.
1994: Jörg Reimann; A Rudolphi; Mogens H Claesson
Reconstitution of SCID mice with low numbers of CD4+ TCR alpha beta + T cells.
Research in immunology 1994;145(5):332-7.
1994: Jörg Reimann; R A Phillips
58th forum in immunology. Models of lymphoid and myeloid reconstruction in SCID mice.
Research in immunology 1994;145(5):323-5.
1994: Reinhold Schirmbeck; K Melber; Thomas Mertens; Jörg Reimann
Selective stimulation of murine cytotoxic T cell and antibody responses by particulate or monomeric hepatitis B virus surface (S) antigen.
European journal of immunology 1994;24(5):1088-96.
1994: A Kuhröber; Reinhold Schirmbeck; Jörg Reimann
Vaccination with T cell receptor peptides primes anti-receptor cytotoxic T lymphocytes (CTL) and anergizes T cells specifically recognized by these CTL.
European journal of immunology 1994;24(5):1172-80.
1994: Reinhold Schirmbeck; K Melber; Thomas Mertens; Jörg Reimann
Antibody and cytotoxic T-cell responses to soluble hepatitis B virus (HBV) S antigen in mice: implication for the pathogenesis of HBV-induced hepatitis.
Journal of virology 1994;68(3):1418-25.
1994: Reinhold Schirmbeck; K Melber; A Kuhröber; Z A Janowicz; Jörg Reimann
Immunization with soluble hepatitis B virus surface protein elicits murine H-2 class I-restricted CD8+ cytotoxic T lymphocyte responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1110-9.
1994: Jörg Reimann; A Rudolphi; G Tcherepnev; Søren Skov; Mogens H Claesson
TCR/CD3 ligation of a TCR-transgenic T lymphoma blocks its proliferation in vitro but does not affect its growth in vivo.
Experimental and clinical immunogenetics 1994;11(4):197-208.
1993: Reinhold Schirmbeck; Wolfgang Deppert; E Kury; Jörg Reimann
In vitro expansion distorts the detectable pattern of specific recognition of in vivo primed cytotoxic T lymphocyte populations.
Cellular immunology 1993;149(2):444-9.
1993: A Rudolphi; K H Enssle; Mogens H Claesson; Jörg Reimann
Adoptive transfer of low numbers of CD4+ T cells into SCID mice chronically treated with soluble IL-4 receptor does not prevent engraftment of IL-4-producing T cells.
Scandinavian journal of immunology 1993;38(1):57-64.
1993: Reinhold Schirmbeck; J Zerrahn; A Kuhröber; Wolfgang Deppert; Jörg Reimann
Immunization of mice with the N-terminal (1-272) fragment of simian virus 40 large T antigen (without adjuvants) specifically primes cytotoxic T lymphocytes.
European journal of immunology 1993;23(7):1528-34.
1993: S Spiess; Jörg Reimann
The diversity of in-frame TCR delta chain transcripts in aging SCID mice.
International immunology 1993;5(6):639-46.
1993: S Spiess; A Kuhröber; Reinhold Schirmbeck; B Arden; Jörg Reimann
Diversity of functional T-cell receptor delta-chain transcripts from bone marrow cells of athymic nude mice.
Immunology 1993;78(2):252-9.
1993: Jörg Reimann; A Rudolphi; T Tscherning; Mogens H Claesson
Selective engraftment of memory CD4+ T cells with an unusual recirculation pattern and a diverse T cell receptor-V beta repertoire into scid mice.
European journal of immunology 1993;23(2):350-6.
1993: A Rudolphi; Jörg Reimann
Transplantation of CD4+ T cell clones into SCID mice.
Journal of immunological methods 1993;158(1):27-36.
1992: A Rudolphi; Mogens H Claesson; Jörg Reimann
CD3+ T cells in severe combined immunodeficiency (scid) mice. VI. Rescue of scid-derived, IgM-producing B cells by transfer of CD4+ CD8- T cells from various lymphoid organs.
Immunology 1992;77(2):157-64.
1992: T Tscherning; Jörg Reimann; Mogens H Claesson
H-2 class I Ld antigen positively selects different TCR V beta gene products in CD8+ and CD4+ T cells.
Scandinavian journal of immunology 1992;36(4):617-9.
1992: S Spiess; A Kuhröber; Reinhold Schirmbeck; Jörg Reimann
Bone marrow cells of athymic nude mice express functional T cell receptor alpha chain transcripts rearranged to V delta 2, 3, 4, 5, 6 genes.
European journal of immunology 1992;22(7):1939-42.
1992: Reinhold Schirmbeck; J Zerrahn; A Kuhröber; E Kury; Wolfgang Deppert; Jörg Reimann
Immunization with soluble simian virus 40 large T antigen induces a specific response of CD3+ CD4- CD8+ cytotoxic T lymphocytes in mice.
European journal of immunology 1992;22(3):759-66.
1991: T Tscherning; A Rudolphi; Jörg Reimann; Mogens H Claesson
CD3+ T cells in severe combined immunodeficiency (SCID) mice. V. Allogeneic T cells engrafted into SCID mice do not induce graft-versus-host disease in spite of the absence of host veto and natural suppressor cell activity.
Scandinavian journal of immunology 1991;34(6):795-801.
1991: Jörg Reimann; A Rudolphi; Mogens H Claesson
Selective reconstitution of T lymphocyte subsets in scid mice.
Immunological reviews 1991;124():75-95.
1991: Mogens H Claesson; A Rudolphi; T Tscherning; Jörg Reimann
CD3+ T cells in severe combined immunodeficiency (scid) mice. IV. Graft-vs.-host resistance of H-2d scid mice to intravenous injection of allogeneic H-2b (C57BL/6) spleen cells.
European journal of immunology 1991;21(9):2057-62.
1991: Jörg Reimann; A Rudolphi; Mogens H Claesson
CD3+ T-cells in severe combined immunodeficiency (scid) mice. III. Transferred congenic, selfreactive CD4+ T cell clones rescue IgM-producing, scid-derived B cells.
International immunology 1991;3(7):657-63.
1991: A Rudolphi; S Spiess; P Conradt; Mogens H Claesson; Jörg Reimann
CD3+ T cells in severe combined immunodeficiency (scid) mice. II. Transplantation of dm2 lymphoid cells into semi-allogeneic scid mice.
European journal of immunology 1991;21(7):1591-600.
1991: A Rudolphi; S Spiess; P Conradt; M H Claësson; Jörg Reimann
CD3+ T cells in severe combined immune deficiency (scid) mice. I. Transferred purified CD4+ T cells, but not CD8+ T cells are engrafted in the spleen of congenic scid mice.
European journal of immunology 1991;21(2):523-33.
1988: Jörg Reimann; A Bellan; P Conradt
Development of autoreactive L3T4+ T cells from double-negative (L3T4-/Ly-2-) Thy-1+ spleen cells of normal mice.
European journal of immunology 1988;18(7):989-99.
1988: Jörg Reimann; A Bellan
Limiting dilution analysis of the response of murine L3T4+ spleen cells to alloantigen.
Scandinavian journal of immunology 1988;27(4):373-83.
1987: Klaus Heeg; Christiane Steeg; Dieter Kabelitz; Jörg Reimann; H Wagner
Clonal specificity analysis of mitogen-activated murine T lymphoblasts.
Immunobiology 1987;175(5):431-46.
1987: Dieter Kabelitz; W R Herzog; Klaus Heeg; H Wagner; Jörg Reimann
Human cytotoxic T lymphocytes. III. Large numbers of peripheral blood T cells clonally develop into allorestricted anti-viral cytotoxic T cell populations in vitro.
The Journal of molecular and cellular immunology : JMCI 1987;3(1):49-60.