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Neil Reiner

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Ben C L Chan; Kwok-Pui Fung; H Gong; Margaret Ip; Claude Jolivalt; Ping-Chung Leung; S L Lui; Neil E Reiner; Raymond H See; Clara B S Lau
Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220/pUL5054 and inhibition of MRSA pyruvate kinase.
Emily P Thi; Gaganjit Sanghera; Chris Joon Ho Hong; Neil E Reiner
Identification of the Mycobacterium tuberculosis protein PE-PGRS62 as a novel effector that functions to block phagosome maturation and inhibit iNOS expression.
Nag S Kumar; Christophe Labrière; Tian Lian; Anne Moreau; Neil E Reiner; Raymond H See; Natalie C Strynadka; Lisa Thorson; Edwin W Y Wong; Liam Worrall; Emily A Amandoron; Artem Cherkasov; Huansheng Gong; Linda Jackson; Sukhbir Kaur; Roya Zoraghi; B Brett Finlay; Robert N Young
Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents.

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2013: Ben C L Chan; Kwok-Pui Fung; H Gong; Margaret Ip; Claude Jolivalt; Ping-Chung Leung; S L Lui; Neil E Reiner; Raymond H See; Clara B S Lau
Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220/pUL5054 and inhibition of MRSA pyruvate kinase.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2013;20(7):611-4.
2013: Emily P Thi; Gaganjit Sanghera; Chris Joon Ho Hong; Neil E Reiner
Identification of the Mycobacterium tuberculosis protein PE-PGRS62 as a novel effector that functions to block phagosome maturation and inhibit iNOS expression.
Cellular microbiology 2013;15(5):795-808.
2012: Nag S Kumar; Christophe Labrière; Tian Lian; Anne Moreau; Neil E Reiner; Raymond H See; Natalie C Strynadka; Lisa Thorson; Edwin W Y Wong; Liam Worrall; Emily A Amandoron; Artem Cherkasov; Huansheng Gong; Linda Jackson; Sukhbir Kaur; Roya Zoraghi; B Brett Finlay; Robert N Young
Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents.
Bioorganic & medicinal chemistry 2012;20(24):7069-82.
2012: Emily P Thi; Neil E Reiner
Phosphatidylinositol 3-kinases and their roles in phagosome maturation.
Journal of leukocyte biology 2012;92(3):553-66.
2012: Ulrike Lambertz; W Robert McMaster; Devki Nandan; Joachim Clos; Leonard J Foster; Judith Maxwell Silverman; Neil E Reiner
Secreted virulence factors and immune evasion in visceral leishmaniasis.
Journal of leukocyte biology 2012;91(6):887-99.
2012: Fidel Martínez-Gutierrez; Erasmo Orrantia; Edward L G Pryzdial; Neil E Reiner; Facundo Ruiz; Elpidio Morales Sánchez; Judith M Silverman; Sarah L Svensson; Emily P Thi; Amanda Vanden Hoek; Yossef Av-Gay; Edward M Conway; Carolina Camargo de Oliveira; Erin C Gaynor; Horacio Bach
Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles.
Nanomedicine : nanotechnology, biology, and medicine 2012;8(3):328-36.
2012: Peter Axerio-Cilies; Emily Amandoron; B Brett Finlay; Leonard J Foster; Huansheng Gong; Michael Hsing; Linda Jackson; Jihong Jiang; Sukhbir Kaur; Nag S Kumar; Tian Lian; W Robert McMaster; Anne Moreau; Neil E Reiner; Raymond H See; Nikolay Stoynov; Natalie C Strynadka; Rick Swayze; Liam Worral; Robert N Young; Roya Zoraghi; Artem Cherkasov
Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase.
ACS chemical biology 2012;7(2):350-9.
2012: Emily P Thi; Ulrike Lambertz; Neil E Reiner
Class IA phosphatidylinositol 3-kinase p110α regulates phagosome maturation.
PloS one 2012;7(8):e43668.
2012: Emily P Thi; Ulrike Lambertz; Neil E Reiner
Sleeping with the enemy: how intracellular pathogens cope with a macrophage lifestyle.
PLoS pathogens 2012;8(3):e1002551.
2011: Ben C L Chan; Kwok-Pui Fung; Carine Ganem-Elbaz; Huansheng Gong; Margaret Ip; Claude Jolivalt; Clara B S Lau; Marc Litaudon; S L Lui; Neil E Reiner; Raymond H See; Ping-Chung Leung
Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase.
Journal of ethnopharmacology 2011;137(1):767-73.
2011: Roya Zoraghi; Raymond H See; Peter Axerio-Cilies; neeraj kumar; Huansheng Gong; Anne Moreau; Michael Hsing; Sukhbir Kaur; Richard D Swayze; Liam Worrall; Emily Amandoron; Tian Lian; Linda Jackson; Jihong Jiang; Lisa Thorson; Christophe Labriere; Leonard Foster; Robert C Brunham; W Robert McMaster; B Brett Finlay; Natalie C Strynadka; Artem Cherkasov; Robert N Young; Neil E Reiner
Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target.
Antimicrobial agents and chemotherapy 2011;55(5):2042-53.
2011: Artem Cherkasov; Michael Hsing; Roya Zoraghi; Leonard J Foster; Raymond H See; Nikolay Stoynov; Jihong Jiang; Sukhbir Kaur; Tian Lian; Linda Jackson; Huansheng Gong; Rick Swayze; Emily Amandoron; Farhad Hormozdiari; Phuong Dao; Cenk Sahinalp; Osvaldo Santos-Filho; Peter Axerio-Cilies; Kendall Byler; W Robert McMaster; Robert brunham; B Brett Finlay; Neil E Reiner
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
Journal of proteome research 2011;10(3):1139-50.
2011: Judith Maxwell Silverman; Neil E Reiner
Leishmania exosomes deliver preemptive strikes to create an environment permissive for early infection.
Frontiers in cellular and infection microbiology 2011;1():26.
2011: Judith Maxwell Silverman; Neil E Reiner
Exosomes and other microvesicles in infection biology: organelles with unanticipated phenotypes.
Cellular microbiology 2011;13(1):1-9.
2010: Judith Maxwell Silverman; Joachim Clos; Eva Horakova; Adele Y Wang; Martina Wiesgigl; Isabelle Kelly; Miriam A Lynn; W Robert McMaster; Leonard J Foster; Megan K Levings; Neil E Reiner
Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(9):5011-22.
2010: Roya Zoraghi; Raymond H See; Huansheng Gong; Tian Lian; Rick Swayze; B Brett Finlay; Robert C Brunham; William R McMaster; Neil E Reiner
Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from methicillin-resistant Staphylococcus aureus.
Biochemistry 2010;49(35):7733-47.
2010: Judith Maxwell Silverman; Joachim Clos; Carolina Camargo de'Oliveira; Omid Shirvani; Yuan Fang; Christine Wang; Leonard J Foster; Neil E Reiner
An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages.
Journal of cell science 2010;123(Pt 6):842-52.
2009: Jimmy S Lee; Neil E Reiner
Stable lentiviral vector-mediated gene silencing in human monocytic cell lines.
Methods in molecular biology (Clifton, N.J.) 2009;531():287-300.
2008: Alireza Moeenrezakhanlou; Lindsay Shephard; Lucia Lam; Neil E Reiner
Myeloid cell differentiation in response to calcitriol for expression CD11b and CD14 is regulated by myeloid zinc finger-1 protein downstream of phosphatidylinositol 3-kinase.
Journal of leukocyte biology 2008;84(2):519-28.
2008: Alireza Moeenrezakhanlou; Devki Nandan; Neil E Reiner
Identification of a calcitriol-regulated Sp-1 site in the promoter of human CD14 using a combined western blotting electrophoresis mobility shift assay (WEMSA).
Biological procedures online 2008;10():29-35.
2008: J Maxwell Silverman; Simon K Chan; Dale P Robinson; Dennis M Dwyer; Devki Nandan; Leonard J Foster; Neil E Reiner
Proteomic analysis of the secretome of Leishmania donovani.
Genome biology 2008;9(2):R35.
2007: Jimmy S Lee; William M Nauseef; Alireza Moeenrezakhanlou; Laura M Sly; Sanaâ Noubir; Kevin Leidal; Jamie M Schlomann; Gerald Krystal; Neil E Reiner
Monocyte p110alpha phosphatidylinositol 3-kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production.
Journal of leukocyte biology 2007;81(6):1548-61.
2007: Wei Ma; Sasmita Mishra; Katrina Gee; Jyoti P Mishra; Devki Nandan; Neil E Reiner; Jonathan B Angel; Ashok Kumar
Cyclosporin A and FK506 inhibit IL-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated phosphoinositide 3-kinase in lipopolysaccharide-stimulated human monocytic cells.
The Journal of biological chemistry 2007;282(18):13351-62.
2007: Alireza Moeenrezakhanlou; Devki Nandan; Lindsay Shephard; Neil E Reiner
1alpha,25-dihydroxycholecalciferol activates binding of CREB to a CRE site in the CD14 promoter and drives promoter activity in a phosphatidylinositol-3 kinase-dependent manner.
Journal of leukocyte biology 2007;81(5):1311-21.
2007: Devki Nandan; Martin Lopez; Fuqiang Ban; Meilan Huang; Yvonne Li; Neil E Reiner; Artem Cherkasov
Indel-based targeting of essential proteins in human pathogens that have close host orthologue(s): discovery of selective inhibitors for Leishmania donovani elongation factor-1alpha.
Proteins 2007;67(1):53-64.
2006: Carlos Leon; Devki Nandan; Martin Lopez; Alireza Moeenrezakhanlou; Neil E Reiner
Annexin V associates with the IFN-gamma receptor and regulates IFN-gamma signaling.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):5934-42.
2006: Artem Cherkasov; Shang-Jung Lee; Devki Nandan; Neil E Reiner
Large-scale survey for potentially targetable indels in bacterial and protozoan proteins.
Proteins 2006;62(2):371-80.
2006: Sanaâ Noubir; Jimmy S Lee; Neil E Reiner
Pleiotropic effects of phosphatidylinositol 3-kinase in monocyte cell regulation.
Progress in nucleic acid research and molecular biology 2006;81():51-95.
2005: Khalid Sendide; Neil E Reiner; Jimmy S I Lee; Sylvain Bourgoin; Amina Talal; Zakaria Hmama
Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4210-9.
2005: Devki Nandan; Neil E Reiner
Leishmania donovani engages in regulatory interference by targeting macrophage protein tyrosine phosphatase SHP-1.
Clinical immunology (Orlando, Fla.) 2005;114(3):266-77.
2005: Neil E Reiner
Targeting cell regulation promotes pathogen survival in macrophages.
Clinical immunology (Orlando, Fla.) 2005;114(3):213-5.
2005: Artem Cherkasov; Devki Nandan; Neil E Reiner
Selective targeting of indel-inferred differences in spatial structures of highly homologous proteins.
Proteins 2005;58(4):950-4.
2004: Sanaâ Noubir; Zakaria Hmama; Neil E Reiner
Dual receptors and distinct pathways mediate interleukin-1 receptor-associated kinase degradation in response to lipopolysaccharide. Involvement of CD14/TLR4, CR3, and phosphatidylinositol 3-kinase.
The Journal of biological chemistry 2004;279(24):25189-95.
2004: Zakaria Hmama; Khalid Sendide; Amina Talal; Rosa Garcia; Karen Dobos; Neil E Reiner
Quantitative analysis of phagolysosome fusion in intact cells: inhibition by mycobacterial lipoarabinomannan and rescue by an 1alpha,25-dihydroxyvitamin D3-phosphoinositide 3-kinase pathway.
Journal of cell science 2004;117(Pt 10):2131-40.
2004: Jimmy S Lee; Zakaria Hmama; Alice L-F Mui; Neil E Reiner
Stable gene silencing in human monocytic cell lines using lentiviral-delivered small interference RNA. Silencing of the p110alpha isoform of phosphoinositide 3-kinase reveals differential regulation of adherence induced by 1alpha,25-dihydroxycholecalciferol and bacterial lipopolysaccharide.
The Journal of biological chemistry 2004;279(10):9379-88.
2003: Devki Nandan; Artem Cherkasov; Rafat Sabouti; Taolin Yi; Neil E Reiner
Molecular cloning, biochemical and structural analysis of elongation factor-1 alpha from Leishmania donovani: comparison with the mammalian homologue.
Biochemical and biophysical research communications 2003;302(4):646-52.
2003: Martín López; Laura M Sly; Yvonne Luu; Douglas Young; Howard Cooper; Neil E Reiner
The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2409-16.
2003: Laura M Sly; Suzanne M Hingley-Wilson; Neil E Reiner; W Robert McMaster
Survival of Mycobacterium tuberculosis in host macrophages involves resistance to apoptosis dependent upon induction of antiapoptotic Bcl-2 family member Mcl-1.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):430-7.
2002: Devki Nandan; Taolin Yi; Martin Lopez; Crystal Lai; Neil E Reiner
Leishmania EF-1alpha activates the Src homology 2 domain containing tyrosine phosphatase SHP-1 leading to macrophage deactivation.
The Journal of biological chemistry 2002;277(51):50190-7.
2002: Laura M Sly; Donald G Guiney; Neil E Reiner
Salmonella enterica serovar Typhimurium periplasmic superoxide dismutases SodCI and SodCII are required for protection against the phagocyte oxidative burst.
Infection and immunity 2002;70(9):5312-5.
2001: Laura M Sly; Martin Lopez; William M Nauseef; Neil E Reiner
1alpha,25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase.
The Journal of biological chemistry 2001;276(38):35482-93.
2001: Marc Lesnick; Neil E Reiner; Joshua Fierer; Donald G Guiney
The Salmonella spvB virulence gene encodes an enzyme that ADP-ribosylates actin and destabilizes the cytoskeleton of eukaryotic cells.
Molecular microbiology 2001;39(6):1464-70.
2000: Devki Nandan; KL Knutson; Raymond Lo; Neil E Reiner
Exploitation of host cell signaling machinery: activation of macrophage phosphotyrosine phosphatases as a novel mechanism of molecular microbial pathogenesis.
Journal of leukocyte biology 2000;67(4):464-70.
1999: Zakaria Hmama; Devki Nandan; Laura M Sly; KL Knutson; P Herrera-Velit; Neil E Reiner
1alpha,25-dihydroxyvitamin D(3)-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex.
The Journal of experimental medicine 1999;190(11):1583-94.
1999: Devki Nandan; Raymond Lo; Neil E Reiner
Activation of phosphotyrosine phosphatase activity attenuates mitogen-activated protein kinase signaling and inhibits c-FOS and nitric oxide synthase expression in macrophages infected with Leishmania donovani.
Infection and immunity 1999;67(8):4055-63.
1999: Zakaria Hmama; KL Knutson; P Herrera-Velit; Devki Nandan; Neil E Reiner
Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1, and cytohesin-1. Regulation by Rho and phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1999;274(2):1050-7.
1998: Zakaria Hmama; Reinhard Gabathuler; Wilfred A Jefferies; G de Jong; Neil E Reiner
Attenuation of HLA-DR expression by mononuclear phagocytes infected with Mycobacterium tuberculosis is related to intracellular sequestration of immature class II heterodimers.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4882-93.
1998: JS Martens; Neil E Reiner; P Herrera-Velit; Urs P Steinbrecher
Phosphatidylinositol 3-kinase is involved in the induction of macrophage growth by oxidized low density lipoprotein.
The Journal of biological chemistry 1998;273(9):4915-20.
1998: KL Knutson; Zakaria Hmama; P Herrera-Velit; R Rochford; Neil E Reiner
Lipoarabinomannan of Mycobacterium tuberculosis promotes protein tyrosine dephosphorylation and inhibition of mitogen-activated protein kinase in human mononuclear phagocytes. Role of the Src homology 2 containing tyrosine phosphatase 1.
The Journal of biological chemistry 1998;273(1):645-52.
1997: P Herrera-Velit; KL Knutson; Neil E Reiner
Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-zeta in bacterial lipopolysaccharide-treated human monocytes.
The Journal of biological chemistry 1997;272(26):16445-52.
1997: Jose Rey-Ladino; Phalgun B Joshi; B Singh; R Gupta; Neil E Reiner
Leishmania major: molecular cloning, sequencing, and expression of the heat shock protein 60 gene reveals unique carboxy terminal peptide sequences.
Experimental parasitology 1997;85(3):249-63.
1997: Devki Nandan; Neil E Reiner
TGF-beta attenuates the class II transactivator and reveals an accessory pathway of IFN-gamma action.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1095-101.
1996: P Herrera-Velit; Neil E Reiner
Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phosphatidylinositol 3-kinase in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1157-65.
1995: Devki Nandan; Neil E Reiner
Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1.
Infection and immunity 1995;63(11):4495-500.
1994: M K Liu; P Herrera-Velit; Roger Brownsey; Neil E Reiner
CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2642-52.
1994: Neil E Reiner
Altered cell signaling and mononuclear phagocyte deactivation during intracellular infection.
Immunology today 1994;15(8):374-81.
1994: M K Liu; Roger Brownsey; Neil E Reiner
Gamma interferon induces rapid and coordinate activation of mitogen-activated protein kinase (extracellular signal-regulated kinase) and calcium-independent protein kinase C in human monocytes.
Infection and immunity 1994;62(7):2722-31.
1993: J A Rey-Ladino; Neil E Reiner
Expression of 65- and 67-kilodalton heat-regulated proteins and a 70-kilodalton heat shock cognate protein of Leishmania donovani in macrophages.
Infection and immunity 1993;61(8):3265-72.
1992: M Olivier; Roger Brownsey; Neil E Reiner
Defective stimulus-response coupling in human monocytes infected with Leishmania donovani is associated with altered activation and translocation of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7481-5.
1992: W C Kwan; W Robert McMaster; N Wong; Neil E Reiner
Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.
Infection and immunity 1992;60(5):2115-20.
1992: M Olivier; Kenneth G Baimbridge; Neil E Reiner
Stimulus-response coupling in monocytes infected with Leishmania. Attenuation of calcium transients is related to defective agonist-induced accumulation of inositol phosphates.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):1188-96.
1991: L L Button; Neil E Reiner; W Robert McMaster
Modification of GP63 genes from diverse species of Leishmania for expression of recombinant protein at high levels in Escherichia coli.
Molecular and biochemical parasitology 1991;44(2):213-24.
1990: Neil E Reiner; W Ng; C B Wilson; W Robert McMaster; S K Burchett
Modulation of in vitro monocyte cytokine responses to Leishmania donovani. Interferon-gamma prevents parasite-induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1.
The Journal of clinical investigation 1990;85(6):1914-24.
1989: Neil E Reiner; R Lo; Alejandro Llanos-Cuentas; Humberto Guerra; L L Button; W Robert McMaster
Genetic heterogeneity in Peruvian Leishmania isolates.
The American journal of tropical medicine and hygiene 1989;41(4):416-21.
1988: Neil E Reiner; W Ng; T Ma; W Robert McMaster
Kinetics of gamma interferon binding and induction of major histocompatibility complex class II mRNA in Leishmania-infected macrophages.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4330-4.
1988: Neil E Reiner; L A Schultz; C J Malemud
Eicosanoid metabolism by Leishmania donovani-infected macrophages: mouse strain responses in prostanoid synthesis.
The American journal of tropical medicine and hygiene 1988;38(1):59-64.
1987: Neil E Reiner; W Ng; W Robert McMaster
Parasite-accessory cell interactions in murine leishmaniasis. II. Leishmania donovani suppresses macrophage expression of class I and class II major histocompatibility complex gene products.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(6):1926-32.