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Dirk Reinhold

Research Profile

Chemicals & Drugs

Physiology

Lymphocyte Activation

Anatomy

Living Beings

Mouse

Disorders

Autoimmune Experimental Encephalomyelitis

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Publications

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Dirk Roggenbuck; Dirk Reinhold; Dimitrios P Bogdanos; Karsten Conrad; René-Louis Humbel; Martin W Laass
Glycoprotein 2 antibodies in inflammatory bowel disease: no association with disease phenotype?
Anja Thielitz; A Wiede; M Lotzing; Dirk Reinhold; M Bellutti; B Bonnekoh; I Franke; H Gollnick
Progressive lipo-lymphedema associated with increased activity of dermal fibroblasts in monoclonal gammopathy of undetermined significance: is there a causal relationship?
Diana Stoye; Claudia Schubert; Stefan Brocke; Alexander Goihl; Kurt Grüngreiff; Karina Guttek; Annegret Reinhold; Dirk Reinhold
Zinc aspartate suppresses T cell activation in vitro and relapsing experimental autoimmune encephalomyelitis in SJL/J mice.

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2013: Dirk Roggenbuck; Dirk Reinhold; Dimitrios P Bogdanos; Karsten Conrad; René-Louis Humbel; Martin W Laass
Glycoprotein 2 antibodies in inflammatory bowel disease: no association with disease phenotype?
Journal of pediatric gastroenterology and nutrition 2013;56(1):e5.
2012: Anja Thielitz; A Wiede; M Lotzing; Dirk Reinhold; M Bellutti; B Bonnekoh; I Franke; H Gollnick
Progressive lipo-lymphedema associated with increased activity of dermal fibroblasts in monoclonal gammopathy of undetermined significance: is there a causal relationship?
Lymphology 2012;45(3):124-9.
2012: Diana Stoye; Claudia Schubert; Stefan Brocke; Alexander Goihl; Kurt Grüngreiff; Karina Guttek; Annegret Reinhold; Dirk Reinhold
Zinc aspartate suppresses T cell activation in vitro and relapsing experimental autoimmune encephalomyelitis in SJL/J mice.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2012;25(3):529-39.
2012: Alexander Goihl; Thilo Kähne; Annegret Reinhold; Anna-Maria Rolle; Sabine Wrenger; Dirk Reinhold
Methodologic issues in the measurement of interleukin-16 in clinical blood samples using immunoassays.
Cytokine 2012;58(1):1-5.
2012: Karsten Conrad; Annelore Ittenson; Dirk Reinhold; Dirk Roggenbuck; Thomas Buettner; Martin W Laass
A new dot immunoassay for simultaneous detection of celiac specific antibodies and IgA-deficiency.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2012;50(2):337-43.
2012: Annika Willitzki; Ulrich Sack; Peter Schierack; Ursula Anderer; Dimitrios P Bogdanos; Karsten Conrad; Rico Hiemann; Vanessa Peters; Dirk Reinhold; Stefan Rödiger; Dirk Roggenbuck
New platform technology for comprehensive serological diagnostics of autoimmune diseases.
Clinical & developmental immunology 2012;2012():284740.
2012: DIMITRIOS BOGDANOS; Karsten Conrad; Alastair Forbes; Peter Malfertheiner; Polychronis Pavlidis; Dirk Reinhold; Dirk Roggenbuck; Ulrike von Arnim; Thomas Wex; Martin W Laass
Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn's disease.
BMC gastroenterology 2012;12():102.
2012: Mauro Togni; Swen Engelmann; Dirk Reinhold; Burkhart Schraven; Annegret Reinhold
The adapter protein ADAP is required for selected dendritic cell functions.
Cell communication and signaling : CCS 2012;10(1):14.
2012: Peter Röhnert; Werner Schmidt; Michael Täger; Sabine Wrenger; Siegfried Ansorge; Ute Bank; Patrick Emmerlich; Alexander Goihl; Karsten Nordhoff; Dirk Reinhold; Frank Striggow
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia.
Journal of neuroinflammation 2012;9():44.
2012: Karsten Conrad; Dirk Reinhold; Dirk Roggenbuck; Ulrich Sack
Autoantibody diagnostics in clinical practice.
Autoimmunity reviews 2012;11(3):207-11.
2011: Aliza Biton; Siegfried Ansorge; Ute Bank; Dirk Reinhold; Michael Täger; Stefan Brocke
Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions.
Immunobiology 2011;216(12):1295-301.
2011: Fahad Haroon; Katrin Drögemüller; Ulrike Händel; Anna Brunn; Dirk Reinhold; Gopala Nishanth; Werner Muller; Christian Trautwein; Matthias Ernst; Martina Deckert; Dirk Schlüter
Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(11):6521-31.
2011: Dirk Roggenbuck; Dirk Reinhold; Thomas Wex; Alexander Goihl; Ulrike von Arnim; Peter Malfertheiner; Thomas Büttner; Tomas Porstmann; Silvia Porstmann; Bodo Liedvogel; Dimitrios P Bogdanos; Martin W Laass; Karsten Conrad
Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease.
Clinica chimica acta; international journal of clinical chemistry 2011;412(9-10):718-24.
2011: Ute Bank; Anke Heimburg; Astrid Wohlfarth; Gudrun Koch; Karsten Nordhoff; Heiko Julius; Martin Helmuth; Doreen Breyer; Dirk Reinhold; Michael Täger; Siegfried Ansorge
Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects.
Biological chemistry 2011;392(3):169-87.
2011: Dirk Reinhold; Ute Bank; Dominik Entz; Alexander Goihl; Diana Stoye; Sabine Wrenger; Stefan Brocke; Anja Thielitz; Sofia Stefin; Karsten Nordhoff; Anke Heimburg; Michael Täger; Siegfried Ansorge
PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J mice.
Biological chemistry 2011;392(3):233-7.
2011: Siegfried Ansorge; Karsten Nordhoff; Ute Bank; Anke Heimburg; Heiko Julius; Doreen Breyer; Anja Thielitz; Dirk Reinhold; Michael Täger
Novel aspects of cellular action of dipeptidyl peptidase IV/CD26.
Biological chemistry 2011;392(3):153-68.
2011: Börge Arndt; Thomas Kalinski; Tina Krieger; Dirk Reinhold; Albert Roessner; Burkhart Schraven; Anja Thielitz; Luca Simeoni
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling.
PloS one 2011;6(9):e23761.
2011: Markus A Hölzl; Johannes Hofer; Johannes J Kovarik; Dirk Roggenbuck; Dirk Reinhold; Alexander Goihl; Miriam Gärtner; Peter Steinberger; Gerhard J Zlabinger
The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I).
Cellular immunology 2011;267(2):88-93.
2010: Kurt Grüngreiff; Dirk Reinhold
Zinc: A complementary factor in the treatment of chronic hepatitis C? (Review).
Molecular medicine reports 2010;3(3):371-5.
2010: Karsten Conrad; Dirk Roggenbuck; Dirk Reinhold; Thomas Dörner
Profiling of rheumatoid arthritis associated autoantibodies.
Autoimmunity reviews 2010;9(6):431-5.
2009: Mandy Pierau; Swen Engelmann; Dirk Reinhold; Thabo Lapp; Burkhart Schraven; Ursula H Bommhardt
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6124-34.
2009: Karsten Conrad; Annelore Ittenson; Dirk Reinhold; Richard Fischer; Dirk Roggenbuck; Thomas Büttner; Hans-Peter Bosselmann; Jörg Steinbach; Werner Schössler
High sensitive detection of double-stranded DNA autoantibodies by a modified Crithidia luciliae immunofluorescence test.
Annals of the New York Academy of Sciences 2009;1173():180-5.
2009: Annegret Reinhold; Sibylle Reimann; Dirk Reinhold; Burkhart Schraven; Mauro Togni
Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo.
Journal of leukocyte biology 2009;86(1):61-71.
2009: Anke Rissmann; Stefanie Pieper; Ines Adams; Thomas Brune; Dagobert Wiemann; Dirk Reinhold
Increased blood plasma concentrations of TGF-beta1 and TGF-beta2 after treatment with intravenous immunoglobulins in childhood autoimmune diseases.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2009;20(3):261-5.
2009: Ulrike C Kuhlmann; Caroline E Chwieralski; Dirk Reinhold; Tobias Welte; Frank Buhling
Radiation-induced matrix production of lung fibroblasts is regulated by interleukin-8.
International journal of radiation biology 2009;85(2):138-43.
2009: Kurt Grüngreiff; Thomas Hebell; Kai Gutensohn; Annegret Reinhold; Dirk Reinhold
Plasma concentrations of zinc, copper, interleukin-6 and interferon-γ, and plasma dipeptidyl peptidase IV activity in chronic hepatitis C.
Molecular medicine reports 2009;2(1):63-8.
2009: Dirk Reinhold; Alexander Goihl; Sabine Wrenger; Annegret Reinhold; Ulrike C Kühlmann; Jürgen Faust; Klaus Neubert; Anja Thielitz; Stefan Brocke; Michael Täger; Siegfried Ansorge; Ute Bank
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009;47(3):268-74.
2009: Siegfried Ansorge; Ute Bank; Anke Heimburg; Martin Helmuth; Gudrun Koch; Janine Tadje; Uwe Lendeckel; Carmen Wolke; Klaus Neubert; Jürgen Faust; Petra Fuchs; Dirk Reinhold; Anja Thielitz; Michael Täger
Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009;47(3):253-61.
2008: Anja Thielitz; Robert Vetter; Bianca Schultze; Sabine Wrenger; Luca Simeoni; Siegfried Ansorge; Klaus Neubert; Jürgen Faust; Petra Lindenlaub; Harald Gollnick; Dirk Reinhold
Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts.
The Journal of investigative dermatology 2008;128(4):855-66.
2008: Sabine Wrenger; Jürgen Faust; Carmen Mrestani-Klaus; Wolfgang Brandt; Anja Thielitz; Klaus Neubert; Dirk Reinhold
Non-substrate peptides influencing dipeptidyl peptidase IV/CD26 activity and immune cell function.
Frontiers in bioscience : a journal and virtual library 2008;13():3194-201.
2008: Anja Thielitz; Siegfried Ansorge; Ute Bank; Michael Tager; Sabine Wrenger; Harald Gollnick; Dirk Reinhold
The ectopeptidases dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN) and their related enzymes as possible targets in the treatment of skin diseases.
Frontiers in bioscience : a journal and virtual library 2008;13():2364-75.
2008: Dirk Reinhold; Ute Bank; Michael Täger; Siegfried Ansorge; Sabine Wrenger; Anja Thielitz; Uwe Lendeckel; Jürgen Faust; Klaus Neubert; Stefan Brocke
DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.
Frontiers in bioscience : a journal and virtual library 2008;13():2356-63.
2007: Claude Grégoire; Sarka Simova; Ying Wang; Amandine Sansoni; Sylvie Richelme; Anja Schmidt-Giese; Luca Simeoni; Pavla Angelisova; Dirk Reinhold; Burkhart Schraven; Vaclav Horejsi; Bernard Malissen; Marie Malissen
Deletion of the LIME adaptor protein minimally affects T and B cell development and function.
European journal of immunology 2007;37(11):3259-69.
2007: Ute Bank; Janine Tadje; Michael Täger; Carmen Wolke; Alicja Bukowska; Annelore Ittenson; Dirk Reinhold; Martin Helmuth; Siegfried Ansorge; Ann Shakespeare; Michael Vieth; Peter Malfertheiner; Michael Naumann; Uwe Lendeckel
Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice.
International journal of molecular medicine 2007;20(4):483-92.
2007: Dirk Reinhold; Aliza Biton; Alexander Goihl; Stefanie Pieper; Uwe Lendeckel; Jürgen Faust; Klaus Neubert; Ute Bank; Michael Täger; Siegfried Ansorge; Stefan Brocke
Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses.
Annals of the New York Academy of Sciences 2007;1110():402-9.
2007: Anja Thielitz; Dirk Reinhold; Robert Vetter; Ute Bank; Martin Helmuth; Roland Hartig; Sabine Wrenger; Ingrid Wiswedel; Uwe Lendeckel; Thilo Kähne; Klaus Neubert; Jürgen Faust; Christos Zouboulis; Siegfried Ansorge; Harald Gollnick
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation.
The Journal of investigative dermatology 2007;127(5):1042-51.
2007: Vera Preller; Annegret Gerber; Sabine Wrenger; Mauro Togni; Didier Marguet; Janine Tadje; Uwe Lendeckel; Christoph Röcken; Jürgen Faust; Klaus Neubert; Burkhart Schraven; Roland Martin; Siegfried Ansorge; Stefan Brocke; Dirk Reinhold
TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4632-40.
2006: Dirk Reinhold; Aliza Biton; Stefanie Pieper; Uwe Lendeckel; Jürgen Faust; Klaus Neubert; Ute Bank; Michael Täger; Siegfried Ansorge; Stefan Brocke
Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
International immunopharmacology 2006;6(13-14):1935-42.
2006: Ute Bank; Anke Heimburg; Martin Helmuth; Sofia Stefin; Uwe Lendeckel; Dirk Reinhold; Jürgen Faust; Petra Fuchs; Bianca Sens; Klaus Neubert; Michael Täger; Siegfried Ansorge
Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel disease.
International immunopharmacology 2006;6(13-14):1925-34.
2006: Sabine Wrenger; Jürgen Faust; Daniel Friedrich; Torsten Hoffmann; Roland Hartig; Uwe Lendeckel; Thilo Kähne; Anja Thielitz; Klaus Neubert; Dirk Reinhold
Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function.
Journal of leukocyte biology 2006;80(3):621-9.
2006: Thomas Schneider; Michael Sailer; Siegfried Ansorge; Raimund Firsching; Dirk Reinhold
Increased concentrations of transforming growth factor beta1 and beta2 in the plasma of patients with glioblastoma.
Journal of neuro-oncology 2006;79(1):61-5.
2006: Uwe Kölsch; Börge Arndt; Dirk Reinhold; Jonathan A Lindquist; Nicole Jüling; Stefanie Kliche; Klaus Pfeffer; Eddy Bruyns; Burkhart Schraven; Luca Simeoni
Normal T-cell development and immune functions in TRIM-deficient mice.
Molecular and cellular biology 2006;26(9):3639-48.
2006: Vera Preller; Annegret Gerber; Mauro Togni; Sabine Wrenger; Burkhart Schraven; Christoph Röcken; Didier Marguet; Siegfried Ansorge; Stefan Brocke; Dirk Reinhold
CD26/DP IV in T cell activation and autoimmunity.
Advances in experimental medicine and biology 2006;575():187-93.
2006: Aliza Biton; Ute Bank; Michael Täger; Siegfried Ansorge; Dirk Reinhold; Uwe Lendeckel; Stefan Brocke
Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
Advances in experimental medicine and biology 2006;575():177-86.
2006: Anja Thielitz; Dirk Reinhold; Robert Vetter; Uwe Lendeckel; Thilo Kähne; Ute Bank; Martin Helmuth; Klaus Neubert; Jürgen Faust; Roland Hartig; Sabine Wrenger; Christos Zouboulis; Siegfried Ansorge; Harald Gollnick
Possible role of DP IV inhibitors in acne therapy.
Advances in experimental medicine and biology 2006;575():163-7.
2006: Ute Bank; Janine Tadje; Martin Helmuth; Sofia Stefin; Michael Täger; Carmen Wolke; Anke Wischeropp; Annelore Ittenson; Dirk Reinhold; Siegfried Ansorge; Uwe Lendeckel
Dipeptidylpeptidase IV (DPIV) and alanyl-aminopeptidases (AAPs) as a new target complex for treatment of autoimmune and inflammatory diseases-proof of concept in a mouse model of colitis.
Advances in experimental medicine and biology 2006;575():143-53.
2006: Sabine Wrenger; Bianca Guth; Bianca Schultze; Torsten Hoffmann; Daniel Friedrich; Thilo Kähne; Jürgen Faust; Klaus Neubert; Dirk Reinhold
Expression of dipeptidyl peptidase IV-like enzymes in human peripheral blood mononuclear cells.
Advances in experimental medicine and biology 2006;575():87-91.
2005: Mauro Togni; Kenneth D Swanson; S Reimann; Stefanie Kliche; A C Pearce; Luca Simeoni; Dirk Reinhold; Jürgen Wienands; Benjamin G Neel; Burkhart Schraven; Annegret Gerber
Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.
Molecular and cellular biology 2005;25(18):8052-63.
2005: Luca Simeoni; Vilmos Posevitz; Uwe Kölsch; Ines Meinert; Eddy Bruyns; Klaus Pfeffer; Dirk Reinhold; Burkhart Schraven
The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.
Molecular and cellular biology 2005;25(17):7557-68.
2005: Caroline Schmidt-Lucke; Funmi M Belgore; Dirk Reinhold; Siegfried Ansorge; Helmut U Klein; J André Schmidt-Lucke; Gregory Y H Lip
Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers.
International journal of cardiology 2005;100(2):207-12.
2005: Kurt Grüngreiff; Dirk Reinhold
Liver cirrhosis and "liver" diabetes mellitus are linked by zinc deficiency.
Medical hypotheses 2005;64(2):316-7.
2004: Thomas Brune; K Masjoshusmann; Dirk Reinhold; J Steinhardt; Rita Exeler; Marianne Volleth; Frank Louwen
The imbalanced mixed lymphocyte reaction between maternal and fetal lymphocytes as well as between the lymphocytes of adult children and their parents is mediated by activated CD8+ T cells.
American journal of reproductive immunology (New York, N.Y. : 1989) 2004;52(4):284-9.
2004: Anja Thielitz; Alicja Bukowska; Carmen Wolke; Robert Vetter; Uwe Lendeckel; Sabine Wrenger; Yuichi Hashimoto; Siegfried Ansorge; Harald Gollnick; Dirk Reinhold
Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation.
Biochemical and biophysical research communications 2004;321(4):795-801.
2004: Dirk Reinhold; Evgeniy Perlov; Kirstin Schrecke; Jörn Kekow; Thomas Brune; Michael Sailer
Increased blood plasma concentrations of TGF-beta isoforms after treatment with intravenous immunoglobulins (i.v.IG) in patients with multiple sclerosis.
Journal of neuroimmunology 2004;152(1-2):191-4.
2003: Susan Lorey; Angela Stöckel-Maschek; Jürgen Faust; Wolfgang Brandt; Beate Stiebitz; mark gorrell; Thilo Kähne; Carmen Mrestani-Klaus; Sabine Wrenger; Dirk Reinhold; Siegfried Ansorge; Klaus Neubert
Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites.
European journal of biochemistry / FEBS 2003;270(10):2147-56.
2003: Caroline Schmidt-Lucke; Dirk Reinhold; Siegfried Ansorge; Helmut U Klein; J André Schmidt-Lucke
Changes of plasma concentrations of soluble vascular cell adhesion molecule-1 and vascular endothelial growth factor after increased perfusion of lower extremities in humans.
Endothelium : journal of endothelial cell research 2003;10(3):159-65.
2003: Jürgen Faust; Petra Fuchs; Sabine Wrenger; Dirk Reinhold; Angela Stöckel-Maschek; Thilo Kähne; Siegfried Ansorge; Klaus Neubert
Dipeptidyl peptidase IV inhibitors with the N-terminal MXP sequence: structure-activity-relationships.
Advances in experimental medicine and biology 2003;524():175-9.
2003: Uwe Lendeckel; Marco Arndt; Alicja Bukowska; Janine Tadje; Carmen Wolke; Thilo Kähne; Klaus Neubert; Jürgen Faust; Annelore Ittenson; Siegfried Ansorge; Dirk Reinhold
Synergistic action of DPIV and APN in the regulation of T cell function.
Advances in experimental medicine and biology 2003;524():123-31.
2003: Carmen Mrestani-Klaus; Wolfgang Brandt; Jürgen Faust; Sabine Wrenger; Dirk Reinhold; Siegfried Ansorge; Klaus Neubert
New results on the conformations of potent DP IV (CD26) inhibitors bearing the N-terminal MWP structural motif.
Advances in experimental medicine and biology 2003;524():65-8.
2002: Dirk Reinhold; Thilo Kähne; Andreas Steinbrecher; Sabine Wrenger; Klaus Neubert; Siegfried Ansorge; Stefan Brocke
The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity.
Biological chemistry 2002;383(7-8):1133-8.
2002: Angela Graness; Caroline E Chwieralski; Dirk Reinhold; Lars Thim; Werner Hoffmann
Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL-8 secretion.
The Journal of biological chemistry 2002;277(21):18440-6.
2002: Uwe Lendeckel; Marco Arndt; Carmen Wolke; Dirk Reinhold; Thilo Kähne; Siegfried Ansorge
Inhibition of human leukocyte function, alanyl aminopeptidase (APN, CD13) and dipeptidylpeptidase IV (DP IV, CD26) enzymatic activities by aqueous extracts of Cistus incanus L. ssp. incanus.
Journal of ethnopharmacology 2002;79(2):221-7.
2001: Andreas Steinbrecher; Dirk Reinhold; Laura Quigley; AM Gado; Nancy Tresser; L Izikson; Ilona Born; Jürgen Faust; Klaus Neubert; Roland Martin; Siegfried Ansorge; Stefan Brocke
Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):2041-8.
2000: Marco Arndt; Uwe Lendeckel; Antje Spiess; Jürgen Faust; Klaus Neubert; Dirk Reinhold; Siegfried Ansorge
Dipeptidyl peptidase IV (DP IV/CD26) mRNA expression in PWM-stimulated T-cells is suppressed by specific DP IV inhibition, an effect mediated by TGF-beta(1).
Biochemical and biophysical research communications 2000;274(2):410-4.
2000: Sabine Wrenger; Jürgen Faust; Carmen Mrestani-Klaus; A Fengler; A Stockel-Maschek; Susan Lorey; T Kahne; Wolfgang Brandt; Klaus Neubert; Siegfried Ansorge; Dirk Reinhold
Down-regulation of T cell activation following inhibition of dipeptidyl peptidase IV/CD26 by the N-terminal part of the thromboxane A2 receptor.
The Journal of biological chemistry 2000;275(29):22180-6.
2000: C H Szymkowiak; E Csernok; Dirk Reinhold; Ute Bank; W L Gross; Jörn Kekow
Neutrophils synthesize and activate TGFbeta2.
Cytokine 2000;12(4):397-400.
2000: Frank Bühling; Annelore Ittenson; D Kaiser; G Thölert; B Hoffmann; Dirk Reinhold; Siegfried Ansorge; T Welte
MRP8/MRP14, CD11b and HLA-DR expression of alveolar macrophages in pneumonia.
Immunology letters 2000;71(3):185-90.
2000: Sabine Wrenger; Thilo Kähne; C Bohuon; Wolfgang Weglöhner; Siegfried Ansorge; Dirk Reinhold
Amino-terminal truncation of procalcitonin, a marker for systemic bacterial infections, by dipeptidyl peptidase IV (DP IV).
FEBS letters 2000;466(1):155-9.
2000: Frank Bühling; Nadine Waldburg; Annegret Gerber; CG Häckel; Sabine Krüger; Dirk Reinhold; Dieter Brömme; Ekkehard Weber; Siegfried Ansorge; Tobias Welte
Cathepsin K expression in human lung.
Advances in experimental medicine and biology 2000;477():281-6.
2000: Robert Vetter; Dirk Reinhold; Frank Bühling; Uwe Lendeckel; Ilona Born; Jürgen Faust; Klaus Neubert; Siegfried Ansorge; Harald Gollnick
DNA synthesis in cultured human keratinocytes and HaCaT keratinocytes is reduced by specific inhibition of dipeptidyl peptidase IV (CD26) enzymatic activity.
Advances in experimental medicine and biology 2000;477():167-71.
2000: Sabine Wrenger; Dirk Reinhold; Jürgen Faust; Carmen Mrestani-Klaus; Wolfgang Brandt; A Fengler; Klaus Neubert; Siegfried Ansorge
Effects of nonapeptides derived from the N-terminal structure of human immunodeficiency virus-1 (HIV-1) Tat on suppression of CD26-dependent T cell growth.
Advances in experimental medicine and biology 2000;477():161-5.
2000: Dirk Reinhold; B Hemmer; Bruno Gran; Andreas Steinbrecher; Stefan Brocke; Thilo Kähne; Sabine Wrenger; Ilona Born; Jürgen Faust; Klaus Neubert; Roland Martin; Siegfried Ansorge
Dipeptidyl peptidase IV (CD26): role in T cell activation and autoimmune disease.
Advances in experimental medicine and biology 2000;477():155-60.
2000: Andreas Steinbrecher; Dirk Reinhold; Laura Quigley; AM Gado; Nancy Tresser; L Izikson; Ilona Born; Jürgen Faust; Klaus Neubert; Roland Martin; Siegfried Ansorge; Stefan Brocke
Dipeptidyl peptidase IV in inflammatory CNS disease.
Advances in experimental medicine and biology 2000;477():145-53.
2000: Marco Arndt; Dirk Reinhold; Uwe Lendeckel; Antje Spiess; Jürgen Faust; Klaus Neubert; Siegfried Ansorge
Specific inhibitors of dipeptidyl peptidase IV suppress mRNA expression of DP IV/CD26 and cytokines.
Advances in experimental medicine and biology 2000;477():139-43.
2000: Thilo Kähne; Dirk Reinhold; Klaus Neubert; Ilona Born; Jürgen Faust; Siegfried Ansorge
Signal transduction events induced or affected by inhibition of the catalytic activity of dipeptidyl peptidase IV (DP IV, CD26).
Advances in experimental medicine and biology 2000;477():131-7.
2000: Carmen Mrestani-Klaus; A Fengler; Jürgen Faust; Wolfgang Brandt; Sabine Wrenger; Dirk Reinhold; Siegfried Ansorge; Klaus Neubert
N-terminal HIV-1 Tat nonapeptides as inhibitors of dipeptidyl peptidase IV. Conformational characterization.
Advances in experimental medicine and biology 2000;477():125-9.
2000: Uwe Lendeckel; Marco Arndt; Karin Frank; Antje Spiess; Dirk Reinhold; Siegfried Ansorge
Modulation of WNT-5A expression by actinonin: linkage of APN to the WNT-pathway?
Advances in experimental medicine and biology 2000;477():35-41.
2000: Uwe Lendeckel; Thilo Kähne; D Riemann; Klaus Neubert; Marco Arndt; Dirk Reinhold
Review: the role of membrane peptidases in immune functions.
Advances in experimental medicine and biology 2000;477():1-24.
1999: Kurt Grüngreiff; Dirk Reinhold; Siegfried Ansorge
Serum concentrations of sIL-2R, IL-6, TGF-beta1, neopterin, and zinc in chronic hepatitis C patients treated with interferon-alpha.
Cytokine 1999;11(12):1076-80.
1999: Ute Bank; B Küpper; Dirk Reinhold; T Hoffmann; Siegfried Ansorge
Evidence for a crucial role of neutrophil-derived serine proteases in the inactivation of interleukin-6 at sites of inflammation.
FEBS letters 1999;461(3):235-40.
1999: Ute Bank; Dirk Reinhold; Christine E Schneemilch; D Kunz; Hans J Synowitz; Siegfried Ansorge
Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(11):1277-87.
1999: Dirk Reinhold; Sabine Wrenger; Thilo Kähne; Siegfried Ansorge
HIV-1 Tat: immunosuppression via TGF-beta1 induction.
Immunology today 1999;20(8):384-5.
1999: T Kahne; Uwe Lendeckel; Sabine Wrenger; Klaus Neubert; Siegfried Ansorge; Dirk Reinhold
Dipeptidyl peptidase IV: a cell surface peptidase involved in regulating T cell growth (review).
International journal of molecular medicine 1999;4(1):3-15.
1999: Frank Bühling; Annegret Gerber; CG Häckel; Sabine Krüger; T Köhnlein; Dieter Brömme; Dirk Reinhold; Siegfried Ansorge; Tobias Welte
Expression of cathepsin K in lung epithelial cells.
American journal of respiratory cell and molecular biology 1999;20(4):612-9.
1999: Frank Bühling; G Thölert; D Kaiser; B Hoffmann; Dirk Reinhold; Siegfried Ansorge; Tobias Welte
Increased release of transforming growth factor (TGF)-beta1, TGF-beta2, and chemoattractant mediators in pneumonia.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(3):271-8.
1999: Dirk Reinhold; Siegfried Ansorge; Kurt Grüngreiff
Immunobiology of zinc and zinc therapy.
Immunology today 1999;20(2):102-3.
1998: Carmen Mrestani-Klaus; A Fengler; Wolfgang Brandt; Jürgen Faust; Sabine Wrenger; Dirk Reinhold; Siegfried Ansorge; Klaus Neubert
1H NMR conformational study on N-terminal nonapeptide sequences of HIV-1 Tat protein: a contribution to structure-activity relationships.
Journal of peptide science : an official publication of the European Peptide Society 1998;4(6):400-10.
1998: Dirk Reinhold; B Hemmer; Bruno Gran; Ilona Born; Jürgen Faust; Klaus Neubert; Henry McFarland; Roland Martin; Siegfried Ansorge
Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones.
Journal of neuroimmunology 1998;87(1-2):203-9.
1998: Dirk Reinhold; Robert Vetter; K Mnich; Frank Bühling; Uwe Lendeckel; Ilona Born; Jürgen Faust; Klaus Neubert; Harald Gollnick; Siegfried Ansorge
Dipeptidyl peptidase IV (DP IV, CD26) is involved in regulation of DNA synthesis in human keratinocytes.
FEBS letters 1998;428(1-2):100-4.
1998: Uta Jappe; Ingolf Franke; Dirk Reinhold; Harald Gollnick
Sebotropic drug reaction resulting from kava-kava extract therapy: a new entity?
Journal of the American Academy of Dermatology 1998;38(1):104-6.
1997: S Schulz; Dirk Reinhold; H Schmidt; Siegfried Ansorge; V Höllt
Perillic acid inhibits Ras/MAP kinase-driven IL-2 production in human T lymphocytes.
Biochemical and biophysical research communications 1997;241(3):720-5.
1997: Sabine Wrenger; Torsten Hoffmann; Jürgen Faust; Carmen Mrestani-Klaus; Wolfgang Brandt; Klaus Neubert; M Kraft; S Olek; R Frank; Siegfried Ansorge; Dirk Reinhold
The N-terminal structure of HIV-1 Tat is required for suppression of CD26-dependent T cell growth.
The Journal of biological chemistry 1997;272(48):30283-8.
1997: Dirk Reinhold; Ute Bank; Frank Bühling; Uwe Lendeckel; Jürgen Faust; Klaus Neubert; Siegfried Ansorge
Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells.
Immunology 1997;91(3):354-60.
1997: Dirk Reinhold; Ute Bank; Frank Bühling; Michael Täger; Ilona Born; Jürgen Faust; Klaus Neubert; Siegfried Ansorge
Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes.
Immunology letters 1997;58(1):29-35.
1997: Ute Bank; Dirk Reinhold; D Kunz; Siegfried Ansorge
Selective proteolytical cleavage of the ligand-binding chains of the IL-2-receptor and IL-6-receptor by neutrophil-derived proteases.
Advances in experimental medicine and biology 1997;421():231-42.
1997: Dirk Reinhold; Thilo Kähne; Michael Täger; Uwe Lendeckel; Frank Bühling; Ute Bank; Sabine Wrenger; Jürgen Faust; Klaus Neubert; Siegfried Ansorge
The effect of anti-CD26 antibodies on DNA synthesis and cytokine production (IL-2, IL-10 and IFN-gamma) depends on enzymatic activity of DP IV/CD26.
Advances in experimental medicine and biology 1997;421():149-55.
1997: Frank Bühling; Dirk Reinhold; Uwe Lendeckel; Jürgen Faust; Klaus Neubert; Siegfried Ansorge
CD26 is involved in regulation of cytokine production in natural killer cells.
Advances in experimental medicine and biology 1997;421():141-7.
1997: Siegfried Ansorge; Frank Bühling; Thilo Kähne; Uwe Lendeckel; Dirk Reinhold; Michael Täger; Sabine Wrenger
CD26/dipeptidyl peptidase IV in lymphocyte growth regulation.
Advances in experimental medicine and biology 1997;421():127-40.
1997: Thomas Wex; Uwe Lendeckel; Dirk Reinhold; Thilo Kähne; Marco Arndt; Karin Frank; Siegfried Ansorge
Antisense-mediated inhibition of aminopeptidase N (CD13) markedly decreases growth rates of hematopoietic tumour cells.
Advances in experimental medicine and biology 1997;421():67-73.
1997: Uwe Lendeckel; Thomas Wex; Dirk Reinhold; Marco Arndt; Annelore Ittenson; Karin Frank; Siegfried Ansorge
Activation-dependent induction of T cell alanyl aminopeptidase and its possible involvement in T cell growth.
Advances in experimental medicine and biology 1997;421():59-66.
1996: Uwe Lendeckel; Thomas Wex; Dirk Reinhold; Thilo Kähne; Karin Frank; Jürgen Faust; Klaus Neubert; Siegfried Ansorge
Induction of the membrane alanyl aminopeptidase gene and surface expression in human T-cells by mitogenic activation.
The Biochemical journal 1996;319 ( Pt 3)():817-21.
1996: U Junker; B Knoefel; K Nuske; K Rebstock; Thomas Steiner; Heiko Wunderlich; Kerstin Junker; Dirk Reinhold
Transforming growth factor beta 1 is significantly elevated in plasma of patients suffering from renal cell carcinoma.
Cytokine 1996;8(10):794-8.
1996: Sabine Wrenger; Dirk Reinhold; T Hoffmann; M Kraft; R Frank; Jürgen Faust; Klaus Neubert; Siegfried Ansorge
The N-terminal X-X-Pro sequence of the HIV-1 Tat protein is important for the inhibition of dipeptidyl peptidase IV (DP IV/CD26) and the suppression of mitogen-induced proliferation of human T cells.
FEBS letters 1996;383(3):145-9.
1996: Dirk Reinhold; Sabine Wrenger; Ute Bank; Frank Bühling; T Hoffmann; Klaus Neubert; M Kraft; R Frank; Siegfried Ansorge
CD26 mediates the action of HIV-1 Tat protein on DNA synthesis and cytokine production in U937 cells.
Immunobiology 1996;195(1):119-28.
1995: T Hoffmann; Dirk Reinhold; Thilo Kähne; Jürgen Faust; Klaus Neubert; R Frank; Siegfried Ansorge
Inhibition of dipeptidyl peptidase IV (DP IV) by anti-DP IV antibodies and non-substrate X-X-Pro- oligopeptides ascertained by capillary electrophoresis.
Journal of chromatography. A 1995;716(1-2):355-62.
1995: Dirk Reinhold; Ute Bank; Frank Bühling; Uwe Lendeckel; Siegfried Ansorge
Transforming growth factor beta 1 inhibits interleukin-10 mRNA expression and production in pokeweed mitogen-stimulated peripheral blood mononuclear cells and T cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(8):685-90.
1995: Ute Bank; Dirk Reinhold; Dagmar Kunz; Hans-Ulrich Schulz; C Schneemilch; W Brandt; Siegfried Ansorge
Effects of interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) on neutrophil elastase release.
Inflammation 1995;19(1):83-99.
1995: Frank Bühling; U Junker; Dirk Reinhold; Klaus Neubert; L Jäger; Siegfried Ansorge
Functional role of CD26 on human B lymphocytes.
Immunology letters 1995;45(1-2):47-51.
1994: Dirk Reinhold; Ute Bank; Frank Bühling; Thilo Kähne; D Kunt; Jürgen Faust; Klaus Neubert; Siegfried Ansorge
Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) specifically suppress proliferation and modulate cytokine production of strongly CD26 expressing U937 cells.
Immunobiology 1994;192(1-2):121-36.
1994: Frank Bühling; D Kunz; Dirk Reinhold; Artur J Ulmer; M Ernst; Hans-Dieter Flad; Siegfried Ansorge
Expression and functional role of dipeptidyl peptidase IV (CD26) on human natural killer cells.
Natural immunity 1994;13(5):270-9.
1994: Dirk Reinhold; Ute Bank; Frank Bühling; Uwe Lendeckel; Artur J Ulmer; Hans-Dieter Flad; Siegfried Ansorge
Transforming growth factor-beta 1 (TGF-beta 1) inhibits DNA synthesis of PWM-stimulated PBMC via suppression of IL-2 and IL-6 production.
Cytokine 1994;6(4):382-8.
1994: Uwe Lendeckel; Thomas Wex; Thilo Kähne; Karin Frank; Dirk Reinhold; Siegfried Ansorge
Expression of the aminopeptidase N (CD13) gene in the human T cell lines HuT78 and H9.
Cellular immunology 1994;153(1):214-26.
1993: Dirk Reinhold; Ute Bank; Frank Bühling; Klaus Neubert; T Mattern; Artur J Ulmer; Hans-Dieter Flad; Siegfried Ansorge
Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells, and IL-2 and IL-6 production.
Immunobiology 1993;188(4-5):403-14.
1991: Ute Bank; Dirk Reinhold; Siegfried Ansorge
[Measurement of cellular activity with the MTT test. Optimization of the method].
Allergie und Immunologie 1991;37(3-4):119-23.
1990: Dirk Reinhold; Siegfried Ansorge
[IL-2 production by peripheral blood mononuclear cells after stimulation with pokeweed mitogen].
Allergie und Immunologie 1990;36(4):293-8.