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Pieter Reitsma

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Huma Safdar; Daniela Salvatori; Ka Lei Cheung; El Houari Laghmani; Pieter H Reitsma; Henri H Versteeg; Gerry T M Wagenaar; Bart J M van Vlijmen
Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production.
Frits R Rosendaal; Pieter H Reitsma
May editorial.
M Raps; Pieter H Reitsma; Frits R Rosendaal; Jan Rosing; Per Morten Sandset; Anders Dahm; K Fleischer; Frans M Helmerhorst; H A A M Van Vliet
The effect of different hormonal contraceptives on plasma levels of free protein S and free TFPI.

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2013: Huma Safdar; Daniela Salvatori; Ka Lei Cheung; El Houari Laghmani; Pieter H Reitsma; Henri H Versteeg; Gerry T M Wagenaar; Bart J M van Vlijmen
Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production.
Blood 2013;121(21):4413-6.
2013: Frits R Rosendaal; Pieter H Reitsma
May editorial.
Journal of thrombosis and haemostasis : JTH 2013;11(5):793-4.
2013: M Raps; Pieter H Reitsma; Frits R Rosendaal; Jan Rosing; Per Morten Sandset; Anders Dahm; K Fleischer; Frans M Helmerhorst; H A A M Van Vliet
The effect of different hormonal contraceptives on plasma levels of free protein S and free TFPI.
Thrombosis and haemostasis 2013;109(4):606-13.
2013: Jiong-Wei Wang; Eveline A M Bouwens; Hetty C de Boer; Koen Mertens; Maria Carolina Pintao; Pieter H Reitsma; Huma Safdar; Karin Valentijn; Jan Voorberg; J C J Eikenboom
Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease.
Blood 2013;121(14):2762-72.
2013: Frits R Rosendaal; Pieter H Reitsma
April editorial.
Journal of thrombosis and haemostasis : JTH 2013;11(4):575.
2013: Frits R Rosendaal; Pieter H Reitsma
March editorial.
Journal of thrombosis and haemostasis : JTH 2013;11(3):401.
2013: Lisa G van den Hengel; Annemarie M van Oeveren-Rietdijk; Anton-Jan van Zonneveld; Henri H Versteeg; Hetty C de Boer; Margreet R De Vries; Jaap F Hamming; Alwine A Hellingman; Anne Yael Nossent; Pieter H Reitsma; C Arnold Spek; Paul H A Quax
Protease-Activated Receptor (PAR)2, but Not PAR1, Is Involved in Collateral Formation and Anti-Inflammatory Monocyte Polarization in a Mouse Hind Limb Ischemia Model.
PloS one 2013;8(4):e61923.
2013: Henri H Versteeg; Johan W M Heemskerk; Marcel Levi; Pieter H Reitsma
New fundamentals in hemostasis.
Physiological reviews 2013;93(1):327-58.
2013: Frits R Rosendaal; Pieter H Reitsma
New editorial crew.
Journal of thrombosis and haemostasis : JTH 2013;11(1):1.
2013: Lisa G van den Hengel; Susanne Osanto; Pieter H Reitsma; Henri H Versteeg
Murine tissue factor coagulant activity is critically dependent on the presence of an intact allosteric disulfide.
Haematologica 2013;98(1):153-8.
2012: J W Wang; B S Dragt; Pieter H Reitsma; Jack A Valentijn; Karin Valentijn; Jan Voorberg; J C J Eikenboom
Formation of platelet-binding von Willebrand factor strings on non-endothelial cells.
Journal of thrombosis and haemostasis : JTH 2012;10(10):2168-78.
2012: Hugoline G de Haan; James J Devlin; C J M Doggen; Saskia Le Cessie; Pieter H Reitsma; Frits R Rosendaal; Carmen H Tong; Andre R Arellano; Lance A Bare; Irene D Bezemer; Carla Y Vossen
Multiple SNP testing improves risk prediction of first venous thrombosis.
Blood 2012;120(3):656-63.
2012: Jiong-Wei Wang; Guy Cosemans; Richard J Dirven; Dafna J Groeneveld; Pieter H Reitsma; Karine M Valentijn; Jan Voorberg; J C J Eikenboom
Biogenesis of Weibel-Palade bodies in von Willebrand's disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation.
Haematologica 2012;97(6):859-66.
2012: Pieter H Reitsma; Henri H Versteeg; Saskia Middeldorp
Mechanistic view of risk factors for venous thromboembolism.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(3):563-8.
2012: Yascha W van den Berg; Susanne Osanto; Pieter H Reitsma; Henri H Versteeg
The relationship between tissue factor and cancer progression: insights from bench and bedside.
Blood 2012;119(4):924-32.
2012: Huma Safdar; Hans L Vos; Ka Lei Cheung; Frank J Gonzalez; Yusuke Inoue; Pieter H Reitsma; Bart J M van Vlijmen
Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.
PloS one 2012;7(6):e38104.
2011: Jorine S Koenderman; Pieter H Reitsma; Rogier M Bertina; Marieke C H de Visser
Factor IX-R338L (Factor IX Padua) screening in a Dutch population of sibpairs with early onset venous thromboembolism.
Thrombosis research 2011;128(6):603.
2011: Y W Van Den Berg; Pieter H Reitsma
Not exclusively tissue factor: neutrophil extracellular traps provide another link between chemotherapy and thrombosis.
Journal of thrombosis and haemostasis : JTH 2011;9(11):2311-2.
2011: Lisa G van den Hengel; Begüm Kocatürk; Pieter H Reitsma; Wolfram Ruf; Henri H Versteeg
Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor.
Blood 2011;118(12):3446-8.
2011: Marieke C H de Visser; Frits R Rosendaal; Sara Roshani; Julie W Rutten; Astrid Van Hylckama Vlieg; Hans L Vos; Pieter H Reitsma
Haplotypes of VKORC1, NQO1 and GGCX, their effect on activity levels of vitamin K-dependent coagulation factors, and the risk of venous thrombosis.
Thrombosis and haemostasis 2011;106(3):563-5.
2011: Audrey C A Cleuren; Iris Postmus; Pieter H Reitsma; Hans L Vos; Bart J M van Vlijmen
Progestins possess poor anti-estrogenic activity on murine hepatic coagulation gene transcription despite evident anti-estrogenic activity on uterine tissue.
Thrombosis research 2011;128(2):200-1.
2011: Jiong-Wei Wang; Hetty C de Boer; Richard J Dirven; Abraham Koster; Pieter H Reitsma; Karine M Valentijn; Anton-Jan van Zonneveld; Jan Voorberg; J C J Eikenboom
Intracellular storage and regulated secretion of von Willebrand factor in quantitative von Willebrand disease.
The Journal of biological chemistry 2011;286(27):24180-8.
2011: L A Bare; I Bezemer; J J Devlin; Willem M Lijfering; Pieter H Reitsma; A R Arellano; C H Tong; Frits R Rosendaal
Genetic variants of F11, statin use and venous thrombosis.
Journal of thrombosis and haemostasis : JTH 2011;9(6):1249-51.
2011: M C Pintao; S Roshani; M C H de Visser; C Tieken; M W T Tanck; I M Wichers; J C M Meijers; Frits R Rosendaal; Saskia Middeldorp; Pieter H Reitsma
High levels of protein C are determined by PROCR haplotype 3.
Journal of thrombosis and haemostasis : JTH 2011;9(5):969-76.
2011: Michael W T Tanck; Iris M Wichers; Joost C M Meijers; Harry R Büller; Pieter H Reitsma; Saskia Middeldorp
Quantitative trait locus for protein C in a family with thrombophilia.
Thrombosis and haemostasis 2011;105(1):199-201.
2010: H Safdar; Y Inoue; G H van Puijvelde; Pieter H Reitsma; Bart J M van Vlijmen
The role of hepatocyte nuclear factor 4α in regulating mouse hepatic anticoagulation and fibrinolysis gene transcript levels.
Journal of thrombosis and haemostasis : JTH 2010;8(12):2839-41.
2010: A C A Cleuren; Irma van der Linden; Y P De Visser; G T M Wagenaar; Pieter H Reitsma; Bart J M van Vlijmen
17α-Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α.
Journal of thrombosis and haemostasis : JTH 2010;8(8):1838-46.
2010: A J M Schreijer; M F Hoylaerts; Joost C M Meijers; H R Lijnen; Saskia Middeldorp; Harry R Büller; Pieter H Reitsma; Frits R Rosendaal; suzanne cannegieter
Explanations for coagulation activation after air travel.
Journal of thrombosis and haemostasis : JTH 2010;8(5):971-8.
2010: Irene D Bezemer; Lance A Bare; Andre R Arellano; Pieter H Reitsma; Frits R Rosendaal
Updated analysis of gene variants associated with deep vein thrombosis.
JAMA : the journal of the American Medical Association 2010;303(5):421-2.
2010: Anja J M Schreijer; Pieter H Reitsma; Suzanne C Cannegieter
High hematocrit as a risk factor for venous thrombosis. Cause or innocent bystander?
Haematologica 2010;95(2):182-4.
2010: Martijn D de Kruif; Maarten Limper; Herman Gerritsen; C Arnold Spek; D P M Brandjes; Hugo ten Cate; Patrick M Bossuyt; Pieter H Reitsma; Eric C M van Gorp
Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department.
Critical care medicine 2010;38(2):457-63.
2010: Martijn D de Kruif; Maarten Limper; Karlien Sierhuis; Jiri F P Wagenaar; C Arnold Spek; Cecilia Garlanda; Alessia Cotena; Alberto Mantovani; Hugo ten Cate; Pieter H Reitsma; Eric C M van Gorp
PTX3 predicts severe disease in febrile patients at the emergency department.
The Journal of infection 2010;60(2):122-7.
2009: Y W van den Berg; L G van den Hengel; H R Myers; O Ayachi; Ekaterina S. Jordanova; W Ruf; C A Spek; Pieter H Reitsma; V Y Bogdanov; H H Versteeg
Alternatively spliced tissue factor induces angiogenesis through integrin ligation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(46):19497-502.
2009: T M H Niers; L W Brüggemann; G L VAN Sluis; R D Liu; H H Versteeg; Harry R Büller; C J F VAN Noorden; Pieter H Reitsma; C A Spek; Dick J Richel
Long-term thrombin inhibition promotes cancer cell extravasation in a mouse model of experimental metastasis.
Journal of thrombosis and haemostasis : JTH 2009;7(9):1595-7.
2009: Maria C Pintao; A A Garcia; D Borgel; M Alhenc-Gelas; C A Spek; M C H de Visser; S Gandrille; Pieter H Reitsma
Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency.
Human genetics 2009;126(3):449-56.
2009: Frits R Rosendaal; Pieter H Reitsma
Genetics of venous thrombosis.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():301-4.
2009: Keren Borensztajn; Maarten F Bijlsma; Pieter H Reitsma; Maikel Peppelenbosch; C Arnold Spek
Coagulation factor Xa inhibits cancer cell migration via protease-activated receptor-1 activation.
Thrombosis research 2009;124(2):219-25.
2009: Irene D Bezemer; Andre R Arellano; Carmen H Tong; Charles M Rowland; Helen A Ireland; Kenneth A Bauer; Joseph Catanese; Pieter H Reitsma; Carine J M Doggen; James J Devlin; Frits R Rosendaal; Lance A Bare
F9 Malmö, factor IX and deep vein thrombosis.
Haematologica 2009;94(5):693-9.
2009: Monia Monti; Keren S Borensztajn; Mirko Pinotti; Alessandro Canella; Alessio Branchini; Giovanna Marchetti; Pieter H Reitsma; francesco bernardi; C Arnold Spek
Characterization of the intracellular signalling capacity of natural FXa mutants with reduced pro-coagulant activity.
Thrombosis research 2009;123(6):914-8.
2009: Iris M Wichers; Michael W T Tanck; Joost C M Meijers; Ton Lisman; Pieter H Reitsma; Frits R Rosendaal; Harry R Büller; Saskia Middeldorp
Assessment of coagulation and fibrinolysis in families with unexplained thrombophilia.
Thrombosis and haemostasis 2009;101(3):465-70.
2009: Rick van Minkelen; Stephanie Bezzina Wettinger; Marieke C H de Visser; Hans L Vos; Pieter H Reitsma; Frits R Rosendaal; Rogier M Bertina; Carine J M Doggen
Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction.
Atherosclerosis 2009;203(1):201-5.
2009: Pieter H Reitsma
How to identify new genetic risk factors for VTE?
Thrombosis research 2009;123 Suppl 4():S22-4.
2009: Elisabeth R Pomp; C J M Doggen; Hans L Vos; Pieter H Reitsma; Frits R Rosendaal
Polymorphisms in the protein C gene as risk factor for venous thrombosis.
Thrombosis and haemostasis 2009;101(1):62-7.
2009: T M H Niers; Lois W Brüggemann; Clara P W Klerk; Femke J M Muller; Tessa Buckle; Pieter H Reitsma; Dick J Richel; C Arnold Spek; Olaf van Tellingen; Cornelis J F Van Noorden
Differential effects of anticoagulants on tumor development of mouse cancer cell lines B16, K1735 and CT26 in lung.
Clinical & experimental metastasis 2009;26(3):171-8.
2008: Lois W Brüggemann; Henri H Versteeg; Tatjana M Niers; Pieter H Reitsma; C Arnold Spek
Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders.
Journal of cellular and molecular medicine 2008;12(6B):2622-7.
2008: H H Versteeg; K S Borensztajn; M E Kerver; W Ruf; Pieter H Reitsma; C A Spek; Maikel Peppelenbosch
TF:FVIIa-specific activation of CREB upregulates proapoptotic proteins via protease-activated receptor-2.
Journal of thrombosis and haemostasis : JTH 2008;6(9):1550-7.
2008: Min Ki Ten Kate; Mathieu Platteel; Rene Mulder; Peter Terpstra; Gerry A F Nicolaes; Pieter H Reitsma; Gerrit van der Steege; Jan van der Meer
PROS1 analysis in 87 pedigrees with hereditary protein S deficiency demonstrates striking genotype-phenotype associations.
Human mutation 2008;29(7):939-47.
2008: Lois W Brüggemann; Henri H Versteeg; Pieter H Reitsma; C Arnold Spek
High factor VIIa levels do not promote tumor metastasis.
Thrombosis and haemostasis 2008;99(4):787-8.
2008: Irene D Bezemer; Lance A Bare; C J M Doggen; Andre R Arellano; Carmen Tong; Charles M Rowland; Joseph Catanese; Bradford A Young; Pieter H Reitsma; James J Devlin; Frits R Rosendaal
Gene variants associated with deep vein thrombosis.
JAMA : the journal of the American Medical Association 2008;299(11):1306-14.
2008: Keren Borensztajn; Jurriën Stiekema; Sebastiaan Nijmeijer; Pieter H Reitsma; Maikel Peppelenbosch; C Arnold Spek
Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation.
The American journal of pathology 2008;172(2):309-20.
2008: Martijn D de Kruif; Tatty E Setiati; Albert T A Mairuhu; Penelope Koraka; Hella A Aberson; C Arnold Spek; Albert D M E Osterhaus; Pieter H Reitsma; D P M Brandjes; Augustinus Soemantri; Eric C M van Gorp
Differential gene expression changes in children with severe dengue virus infections.
PLoS neglected tropical diseases 2008;2(4):e215.
2008: Andrea A Garcia; Pieter H Reitsma
VKORC1 and the vitamin K cycle.
Vitamins and hormones 2008;78():23-33.
2007: Johanna A Kremer-Hovinga; Sacha Zeerleder; P Kessler; Thalia Romani de Wit; Jan A van Mourik; C Erik Hack; Hugo ten Cate; Pieter H Reitsma; Walter A Wuillemin; Bernhard Lämmle
ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock.
Journal of thrombosis and haemostasis : JTH 2007;5(11):2284-90.
2007: Delphine Borgel; Caroline Bornstain; Pieter H Reitsma; Nicolas Lerolle; Sophie Gandrille; Fouad Dali-Ali; Charles T Esmon; Jean-Yves Fagon; Martine Aiach; Jean-Luc Diehl
A comparative study of the protein C pathway in septic and nonseptic patients with organ failure.
American journal of respiratory and critical care medicine 2007;176(9):878-85.
2007: Sjoukje H Slofstra; Maarten F Bijlsma; Angelique P Groot; Pieter H Reitsma; Theo Lindhout; Hugo ten Cate; C Arnold Spek
Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation.
Blood 2007;110(9):3176-82.
2007: Hjalmar R Hansen; Jef L Wolfs; Lois Bruggemann; Dirkje W Sommeijer; Eduard Bevers; Arnaud D Hauer; Johan Kuiper; C Arnold Spek; Henri M H Spronk; Pieter H Reitsma; Hugo ten Cate
Hyperglycemia accelerates arterial thrombus formation and attenuates the antithrombotic response to endotoxin in mice.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2007;18(7):627-36.
2007: Pieter H Reitsma
VKORC1 gene variation and venous thrombosis: 'another one bites the dust'?
Journal of thrombosis and haemostasis : JTH 2007;5(10):2017-9.
2007: Sjoukje H Slofstra; Angelique P Groot; Maartje H P Obdeijn; Pieter H Reitsma; Hugo ten Cate; C Arnold Spek
Gene expression profiling identifies C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation.
American journal of respiratory and critical care medicine 2007;176(6):602-9.
2007: Audrey C A Cleuren; Bart J M van Vlijmen; Pieter H Reitsma
Transgenic mouse models of venous thrombosis: fulfilling the expectations?
Seminars in thrombosis and hemostasis 2007;33(6):610-6.
2007: Keren S Borensztajn; Maarten F Bijlsma; Angelique P Groot; Lois W Brüggemann; Henri H Versteeg; Pieter H Reitsma; Maikel Peppelenbosch; C Arnold Spek
Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation.
Experimental cell research 2007;313(12):2622-33.
2007: Pieter H Reitsma; Frits R Rosendaal
Past and future of genetic research in thrombosis.
Journal of thrombosis and haemostasis : JTH 2007;5 Suppl 1():264-9.
2007: Andrea A Garcia; Niels V van der Hoeven; Thierry N Boellaard; Jeroen F van der Heijden; Angelique P Groot; Pieter H Reitsma
Fibrinogen Aalpha312 and Bbeta448 polymorphisms are not related to bleeding during oral vitamin K-antagonist treatment.
Thrombosis and haemostasis 2007;97(4):676-8.
2007: Pieter H Reitsma
No praise for folly: genomics will never be useful in arterial thrombosis.
Journal of thrombosis and haemostasis : JTH 2007;5(3):454-7.
2007: Anita C T M Peeters; Benien E van Aken; Henk J Blom; Pieter H Reitsma; Martin den Heijer
The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2007;45(1):54-8.
2006: Sjoukje H Slofstra; Angelique P Groot; Nico A Maris; Pieter H Reitsma; H Ten Cate; C Arnold Spek
Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment.
British journal of pharmacology 2006;149(6):740-6.
2006: Tymen T Keller; D Choi; C Nagel; H Te Velthuis; V E A Gerdes; Nicholas J Wareham; Sheila A Bingham; Robert Luben; C Erik Hack; Pieter H Reitsma; Marcel Levi; Kay-Tee Khaw; S Matthijs Boekholdt
Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.
Journal of thrombosis and haemostasis : JTH 2006;4(11):2391-6.
2006: Sverre C Christiansen; Inger Anne Naess; suzanne cannegieter; Jens Hammerstrøm; Frits R Rosendaal; Pieter H Reitsma
Inflammatory cytokines as risk factors for a first venous thrombosis: a prospective population-based study.
PLoS medicine 2006;3(8):e334.
2006: Lois W Brüggemann; Saskia H H F Schoenmakers; Angelique P Groot; Pieter H Reitsma; C Arnold Spek
Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice.
Critical care medicine 2006;34(8):2201-6.
2006: C A R Lok; Anita N Böing; Pieter H Reitsma; Joris A M van der Post; Ed van Bavel; Kees Boer; Augueste Sturk; Rienk Nieuwland
Expression of inflammation-related genes in endothelial cells is not directly affected by microparticles from preeclamptic patients.
The Journal of laboratory and clinical medicine 2006;147(6):310-20.
2006: A A Garcia; Jeroen F van der Heijden; J C M Meijers; Frits R Rosendaal; Pieter H Reitsma
The relationship between ABO blood group and the risk of bleeding during vitamin K antagonist treatment.
Journal of thrombosis and haemostasis : JTH 2006;4(6):1418-20.
2006: Anita W Rijneveld; Sebastiaan Weijer; Paul Bresser; Sandrine Florquin; George P Vlasuk; William E Rote; C Arnold Spek; Pieter H Reitsma; jaring s. van der zee; Marcel Levi; Tom van der Poll
Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia.
Critical care medicine 2006;34(6):1725-30.
2006: Lois W Brüggemann; J W Drijfhout; Pieter H Reitsma; C Arnold Spek
Alternatively spliced tissue factor in mice: induction by Streptococcus pneumoniae.
Journal of thrombosis and haemostasis : JTH 2006;4(4):918-20.
2006: Vivian de Waard; Hjalmar R Hansen; Henri H M Spronk; Janneke J Timmerman; Hans Pannekoek; Sandrine Florquin; Pieter H Reitsma; Hugo ten Cate
Differential expression of tissue factor mRNA and protein expression in murine sepsis. The role of the granulocyte revisited.
Thrombosis and haemostasis 2006;95(2):348-53.
2006: Wendy S Bril; Pauline M W van Helden; Christina Hausl; Marleen G Zuurveld; Rafi U Ahmad; Martine J Hollestelle; Pieter H Reitsma; Karin Fijnvandraat; René A W van Lier; Hans Peter Schwarz; Koen Mertens; Birgit M Reipert; Jan Voorberg
Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg(593) to Cys substitution.
Thrombosis and haemostasis 2006;95(2):341-7.
2006: Pieter H Reitsma
When is cardiovascular genomics delivering on its promise?
Journal of thrombosis and haemostasis : JTH 2006;4(2):339-40.
2005: Saskia H H F Schoenmakers; Lois W Brüggemann; Angelique P Groot; S Maijs; Pieter H Reitsma; C Arnold Spek
Role of coagulation FVIII in septic peritonitis assessed in hemophilic mice.
Journal of thrombosis and haemostasis : JTH 2005;3(12):2738-44.
2005: Marcello Di Nisio; T M H Niers; Pieter H Reitsma; Harry R Buller
Plasma cytokine and P-selectin levels in advanced malignancy: prognostic value and impact of low-molecular weight heparin administration.
Cancer 2005;104(10):2275-81.
2005: Pieter H Reitsma; Jeroen F van der Heijden; Angelique P Groot; Frits R Rosendaal; Harry R Büller
A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk.
PLoS medicine 2005;2(10):e312.
2005: Dirkje W Sommeijer; René Van Oerle; Pieter H Reitsma; Janneke J Timmerman; Joost C M Meijers; Henri M H Spronk; Hugo ten Cate
Analysis of blood coagulation in mice: pre-analytical conditions and evaluation of a home-made assay for thrombin-antithrombin complexes.
Thrombosis journal 2005;3():12.
2005: Dirkje W Sommeijer; K Joop; A Leyte; Pieter H Reitsma; Hugo ten Cate
Pravastatin reduces fibrinogen receptor gpIIIa on platelet-derived microparticles in patients with type 2 diabetes.
Journal of thrombosis and haemostasis : JTH 2005;3(6):1168-71.
2005: Sjoukje H Slofstra; Cornelis van 't Veer; Wim A Buurman; Pieter H Reitsma; Hugo ten Cate; C Arnold Spek
Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation.
Critical care medicine 2005;33(6):1365-70.
2005: Radjesh J Bisoendial; John J P Kastelein; Johannes Levels; Jaap-Jan Zwaginga; Bas van den Bogaard; Pieter H Reitsma; Joost C M Meijers; Daniel Hartman; Marcel Levi; Erik S G Stroes
Activation of inflammation and coagulation after infusion of C-reactive protein in humans.
Circulation research 2005;96(7):714-6.
2005: Saskia Z H Rittersma; Johanna A Kremer-Hovinga; Karel T Koch; S Matthijs Boekholdt; Benien E van Aken; Arko Scheepmaker; Matthijs Bax; Carl E Schotborgh; Jan J Piek; Jan G P Tijssen; Pieter H Reitsma; Robbert J De Winter
Relationship between in vitro lipopolysaccharide-induced cytokine response in whole blood, angiographic in-stent restenosis, and toll-like receptor 4 gene polymorphisms.
Clinical chemistry 2005;51(3):516-21.
2005: Stephanie Bezzina Wettinger; C J M Doggen; C Arnold Spek; Frits R Rosendaal; Pieter H Reitsma
High throughput mRNA profiling highlights associations between myocardial infarction and aberrant expression of inflammatory molecules in blood cells.
Blood 2005;105(5):2000-6.
2005: Christoph L Klein; János Márki-Zay; Philippe Corbisier; David Gancberg; Susan Cooper; Donato Gemmati; Walter-Michael Halbmayer; Steve Kitchen; Béla Melegh; Michael Neumaier; Johannes Oldenburg; Elisabeth Oppliger Leibundgut; Pieter H Reitsma; Sandra Rieger; Heinz Schimmel; Michael Spannagl; Attilia Tordai; Alberto Tosetto; Sophie Visvikis; Renata Zadro; Christine Mannhalter
Reference materials (RMs) for analysis of the human factor II (prothrombin) gene G20210A mutation.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2005;43(8):862-8.
2005: Dirkje W Sommeijer; Sandrine Florquin; Inge Hoedemaker; Janneke J Timmerman; Pieter H Reitsma; Hugo ten Cate
Renal tissue factor expression is increased in streptozotocin-induced diabetic mice.
Nephron. Experimental nephrology 2005;101(3):e86-94.
2005: Saskia H H F Schoenmakers; Pieter H Reitsma; C Arnold Spek
Blood coagulation factors as inflammatory mediators.
Blood cells, molecules & diseases 2005;34(1):30-7.
2004: Saskia H H F Schoenmakers; Henri H Versteeg; Angelique P Groot; Pieter H Reitsma; C Arnold Spek
Tissue factor haploinsufficiency during endotoxin induced coagulation and inflammation in mice.
Journal of thrombosis and haemostasis : JTH 2004;2(12):2185-93.
2004: S Matthijs Boekholdt; Ron J G Peters; Nicholas E Day; Robert Luben; Sheila A Bingham; Nicholas J Wareham; C Erik Hack; Pieter H Reitsma; Kay-Tee Khaw
Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study.
The American journal of medicine 2004;117(6):390-7.
2004: Wouter J de Jonge; Frans O The; Dennis van der Coelen; Roelof J Bennink; Pieter H Reitsma; Sander J H van Deventer; Rene M van den Wijngaard; Guy E Boeckxstaens
Mast cell degranulation during abdominal surgery initiates postoperative ileus in mice.
Gastroenterology 2004;127(2):535-45.
2004: S Matthijs Boekholdt; Ron J G Peters; C Erik Hack; Nicholas E Day; Robert Luben; Sheila A Bingham; Nicholas J Wareham; Pieter H Reitsma; Kay-Tee Khaw
IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(8):1503-8.
2004: Jeroen F van der Heijden; B Rekké; BA Hutten; F J M van der Meer; M G H Remkes; M Vermeulen; Harry R Büller; Pieter H Reitsma
Non-fatal major bleeding during treatment with vitamin K antagonists: influence of soluble thrombomodulin and mutations in the propeptide of coagulation factor IX.
Journal of thrombosis and haemostasis : JTH 2004;2(7):1104-9.
2004: Sebastiaan Weijer; Saskia H H F Schoenmakers; Sandrine Florquin; Marcel Levi; George P Vlasuk; William E Rote; Pieter H Reitsma; C Arnold Spek; Tom van der Poll
Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice.
The Journal of infectious diseases 2004;189(12):2308-17.
2004: V E A Gerdes; Roderik A Kraaijenhagen; Esther W M Vogels; Hugo ten Cate; Pieter H Reitsma
Factor XI gene analysis in thrombophilia and factor XI deficiency.
Journal of thrombosis and haemostasis : JTH 2004;2(6):1015-7.
2004: Pieter H Reitsma
Is hypercoagulability an issue in arterial thrombosis? No.
Journal of thrombosis and haemostasis : JTH 2004;2(5):692-4.
2004: Pieter H Reitsma; Frits R Rosendaal
Activation of innate immunity in patients with venous thrombosis: the Leiden Thrombophilia Study.
Journal of thrombosis and haemostasis : JTH 2004;2(4):619-22.
2004: Saskia Z H Rittersma; S Matthijs Boekholdt; Karel T Koch; Reina Geuzebroek; Matthijs Bax; Carl E Schotborgh; Hetty Eckmann; Ron J G Peters; Jan J Piek; Jan G P Tijssen; Pieter H Reitsma; Robbert J De Winter
Thrombospondin gene polymorphisms and the risk of angiographic coronary in-stent restenosis.
The American journal of medicine 2004;116(7):499-500.
2004: V E A Gerdes; H A Kremer Hovinga; Hugo ten Cate; Melvin R MacGillavry; A Leijte; Pieter H Reitsma; D P M Brandjes; Harry R Büller
Homocysteine and markers of coagulation and endothelial cell activation.
Journal of thrombosis and haemostasis : JTH 2004;2(3):445-51.
2004: Saskia H H F Schoenmakers; Angelique P Groot; Sandrine Florquin; Pieter H Reitsma; C Arnold Spek
Blood cell-derived tissue factor influences host response during murine endotoxemia.
Blood cells, molecules & diseases 2004;32(2):325-33.
2004: Anita W Rijneveld; Sebastiaan Weijer; Sandrine Florquin; Charles T Esmon; Joost C M Meijers; Peter Speelman; Pieter H Reitsma; Hugo ten Cate; Tom van der Poll
Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.
Blood 2004;103(5):1702-9.
2004: Klaartje Kok; Pieter C F Stokkers; Pieter H Reitsma
Genomics and proteomics: implications for inflammatory bowel diseases.
Inflammatory bowel diseases 2004;10 Suppl 1():S1-6.
2004: Frits R Rosendaal; Pieter H Reitsma
Genetic studies in complex disease.
Journal of thrombosis and haemostasis : JTH 2004;2(2):342.
2004: Dirkje W Sommeijer; Melvin R MacGillavry; Joost C M Meijers; Anton P Van Zanten; Pieter H Reitsma; Hugo ten Cate
Anti-inflammatory and anticoagulant effects of pravastatin in patients with type 2 diabetes.
Diabetes care 2004;27(2):468-73.
2004: Johanna A Kremer-Hovinga; Rendrik F Franco; Marco Zago; Hugo ten Cate; Rudi G J Westendorp; Pieter H Reitsma
A functional single nucleotide polymorphism in the thrombin-activatable fibrinolysis inhibitor (TAFI) gene associates with outcome of meningococcal disease.
Journal of thrombosis and haemostasis : JTH 2004;2(1):54-7.
2004: S Matthijs Boekholdt; Ron J G Peters; Moniek P M de Maat; Aeilko H Zwinderman; Ernst E van der Wall; Pieter H Reitsma; J Wouter Jukema; John J P Kastelein
Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events.
American heart journal 2004;147(1):181-6.
2003: Janine Dörffler-Melly; Martijn D de Kruif; Lothar A Schwarte; Rendrik F Franco; Sandrine Florquin; C Arnold Spek; Can Ince; Pieter H Reitsma; Hugo ten Cate
Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis.
Basic research in cardiology 2003;98(6):347-52.
2003: Willeke M C Jong; Pieter H Reitsma; Hugo ten Cate; Robbert J De Winter
Modified two-step model for studying the inflammatory response during myocardial ischemia and reperfusion in mice.
Comparative medicine 2003;53(5):522-6.
2003: Wouter J de Jonge; Rene M van den Wijngaard; Frans O The; Merel-Linde ter Beek; Roelof J Bennink; G N J Tytgat; Ruud M Buijs; Pieter H Reitsma; Sander J H van Deventer; Guy E Boeckxstaens
Postoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in mice.
Gastroenterology 2003;125(4):1137-47.
2003: Marcel Levi; Janine Dörffler-Melly; Pieter H Reitsma; Harry Buller; Sandrine Florquin; Tom van der Poll; Peter Carmeliet
Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice.
Blood 2003;101(12):4823-7.
2003: S Matthijs Boekholdt; Willem R P Agema; Ron J G Peters; Aeilko H Zwinderman; Ernst E van der Wall; Pieter H Reitsma; John J P Kastelein; J Wouter Jukema
Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events.
Circulation 2003;107(19):2416-21.
2003: Pieter H Reitsma; Judith Branger; Bernt van den Blink; Sebastiaan Weijer; Tom van der Poll; Joost C M Meijers
Procoagulant protein levels are differentially increased during human endotoxemia.
Journal of thrombosis and haemostasis : JTH 2003;1(5):1019-23.
2003: C Arnold Spek; Annelies Verbon; Hella Aberson; John P Pribble; Cathal J McElgunn; Terence Turner; Tim Axtelle; Jan Schouten; Tom van der Poll; Pieter H Reitsma
Treatment with an anti-CD14 monoclonal antibody delays and inhibits lipopolysaccharide-induced gene expression in humans in vivo.
Journal of clinical immunology 2003;23(2):132-40.
2003: Annelies Verbon; Joost C M Meijers; C Arnold Spek; C Erik Hack; John P Pribble; Terence Turner; Pascale E P Dekkers; Tim Axtelle; Marcel Levi; Sander J H van Deventer; Pieter H Reitsma; Tom van der Poll
Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans.
The Journal of infectious diseases 2003;187(1):55-61.
2002: S Matthijs Boekholdt; Mieke D Trip; Ron J G Peters; Marc Engelen; Judith M Boer; Edith J M Feskens; Aeilko H Zwinderman; John J P Kastelein; Pieter H Reitsma
Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(12):e24-7.
2002: Alexander P Reiner; Frits R Rosendaal; Pieter H Reitsma; Rozenn N Lemaitre; Rachel Pearce; Yechiel Friedlander; Trivellore E Raghunathan; Bruce M Psaty; David S Siscovick
Factor V Leiden, prothrombin G20210A, and risk of sudden coronary death in apparently healthy persons.
The American journal of cardiology 2002;90(1):66-8.
2002: V E A Gerdes; Hugo ten Cate; Eric de Groot; Vincent I H Kwa; Martin H Prins; Pieter H Reitsma; Harry R Büller; D P M Brandjes
Arterial wall thickness and the risk of recurrent ischemic events in carriers of the prothrombin G20210A mutation with clinical manifestations of atherosclerosis.
Atherosclerosis 2002;163(1):135-40.
2002: Willeke M C Jong; Coert J Zuurbier; Robbert J De Winter; Danyel A F Van Den Heuvel; Pieter H Reitsma; Hugo ten Cate; Can Ince
Fentanyl-fluanisone-midazolam combination results in more stable hemodynamics than does urethane alpha-chloralose and 2,2,2-tribromoethanol in mice.
Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science 2002;41(3):28-32.
2002: Benien E van Aken; Pieter H Reitsma; Frits R Rosendaal
Interleukin 8 and venous thrombosis: evidence for a role of inflammation in thrombosis.
British journal of haematology 2002;116(1):173-7.
2001: Rendrik F Franco; Pieter H Reitsma
Gene polymorphisms of the haemostatic system and the risk of arterial thrombotic disease.
British journal of haematology 2001;115(3):491-506.
2001: Hendrik N van der Vliet; M G Sammels; AC Leegwater; Johannes Levels; Pieter H Reitsma; Willem Boers; Robert Chamuleau
Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration.
The Journal of biological chemistry 2001;276(48):44512-20.
2001: Rendrik F Franco; Pieter H Reitsma
Genetic risk factors of venous thrombosis.
Human genetics 2001;109(4):369-84.
2001: Hugo ten Cate; Saskia H H F Schoenmakers; R Franco; Janneke J Timmerman; Angelique P Groot; C Arnold Spek; Pieter H Reitsma
Microvascular coagulopathy and disseminated intravascular coagulation.
Critical care medicine 2001;29(7 Suppl):S95-7; discussion S97-8.
2001: Marielle van Pampus; Hans Wolf; Maria M W Koopman; Abraham E van den Ende; H R Buller; Pieter H Reitsma
Prothrombin 20210 G: a mutation and Factor V Leiden mutation in women with a history of severe preeclampsia and (H)ELLP syndrome.
Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy 2001;20(3):291-8.
2000: Sophie Gandrille; Delphine Borgel; Núria Sala; Yolanda Espinosa-Parrilla; Rachel E Simmonds; S Rezende; B Lind; C Mannhalter; I Pabinger; Pieter H Reitsma; C Formstone; D N Cooper; H Saito; K Suzuki; francesco bernardi; Martine Aiach
Protein S deficiency: a database of mutations--summary of the first update.
Thrombosis and haemostasis 2000;84(5):918.
2000: Rendrik F Franco; Saskia Middeldorp; Johan R Meinardi; Elisabeth C M van Pampus; Pieter H Reitsma
Factor XIII Val34Leu and the risk of venous thromboembolism in factor V Leiden carriers.
British journal of haematology 2000;111(1):118-21.
2000: Rendrik F Franco; Evert de Jonge; Pascale E P Dekkers; Janneke J Timmerman; C Arnold Spek; Sander J H van Deventer; P van Deursen; L van Kerkhoff; B van Gemen; Hugo ten Cate; Tom van der Poll; Pieter H Reitsma
The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation.
Blood 2000;96(2):554-9.
2000: Pieter C F Stokkers; K Huibregtse; AC Leegwater; Pieter H Reitsma; G N J Tytgat; Sander J H van Deventer
Analysis of a positional candidate gene for inflammatory bowel disease: NRAMP2.
Inflammatory bowel diseases 2000;6(2):92-8.
2000: Benien E van Aken; Martin den Heijer; G M Bos; Sander J H van Deventer; Pieter H Reitsma
Recurrent venous thrombosis and markers of inflammation.
Thrombosis and haemostasis 2000;83(4):536-9.
2000: Benien E van Aken; J Jansen; Sander J H van Deventer; Pieter H Reitsma
Elevated levels of homocysteine increase IL-6 production in monocytic Mono Mac 6 cells.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2000;11(2):159-64.
2000: Pieter H Reitsma
Genetic heterogeneity in hereditary thrombophilia.
Haemostasis 2000;30 Suppl 2():1-10.
2000: Roderik A Kraaijenhagen; P S in't Anker; Maria M W Koopman; Pieter H Reitsma; Martin H Prins; Abraham E van den Ende; Harry R Büller
High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism.
Thrombosis and haemostasis 2000;83(1):5-9.
1999: Pieter C F Stokkers; Pieter H Reitsma; G N J Tytgat; Sander J H van Deventer
HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis.
Gut 1999;45(3):395-401.
1999: C J M Doggen; Rogier M Bertina; VM Cats; Pieter H Reitsma; Frits R Rosendaal
The 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene is not associated with myocardial infarction.
Thrombosis and haemostasis 1999;82(1):115-20.
1999: Pieter C F Stokkers; K de Heer; AC Leegwater; Pieter H Reitsma; G N J Tytgat; Sander J H van Deventer
Inflammatory bowel disease and the genes for the natural resistance-associated macrophage protein-1 and the interferon-gamma receptor 1.
International journal of colorectal disease 1999;14(1):13-7.
1999: Rendrik F Franco; MD Trip; Hugo ten Cate; A van den Ende; Martin H Prins; JJ Kastelein; Pieter H Reitsma
The 20210 G-->A mutation in the 3'-untranslated region of the prothrombin gene and the risk for arterial thrombotic disease.
British journal of haematology 1999;104(1):50-4.
1998: B J Verhoeff; MD Trip; Martin H Prins; JJ Kastelein; Pieter H Reitsma
The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis.
Atherosclerosis 1998;141(1):161-6.
1998: Rendrik F Franco; Marco Zago; MD Trip; Hugo ten Cate; A van den Ende; Martin H Prins; JJ Kastelein; Pieter H Reitsma
Prevalence of hereditary haemochromatosis in premature atherosclerotic vascular disease.
British journal of haematology 1998;102(5):1172-5.
1998: Robbert J De Winter; Saskia Middeldorp; S Gaffar; Karel T Koch; Jan J Piek; Marcel Levi; Pieter H Reitsma
Acute myocardial infarction with large bilateral intracoronary thrombi in a young patient with the prothrombin 20210 G-->A mutation.
Catheterization and cardiovascular diagnosis 1998;44(4):427-30.
1998: C J M Doggen; V Manger Cats; Rogier M Bertina; Pieter H Reitsma; Jan P Vandenbroucke; Frits R Rosendaal
A genetic propensity to high factor VII is not associated with the risk of myocardial infarction in men.
Thrombosis and haemostasis 1998;80(2):281-5.
1998: Pieter C F Stokkers; B E van Aken; N Basoski; Pieter H Reitsma; G N J Tytgat; Sander J H van Deventer
Five genetic markers in the interleukin 1 family in relation to inflammatory bowel disease.
Gut 1998;43(1):33-9.
1998: J F Guasch; suzanne cannegieter; Pieter H Reitsma; E T van't Veer-Korthof; Rogier M Bertina
Severe coagulation factor V deficiency caused by a 4 bp deletion in the factor V gene.
British journal of haematology 1998;101(1):32-9.
1998: Frits R Rosendaal; C J M Doggen; A Zivelin; V R Arruda; M Aiach; D S Siscovick; A Hillarp; H H Watzke; F Bernardi; A M Cumming; F Eric Preston; Pieter H Reitsma
Geographic distribution of the 20210 G to A prothrombin variant.
Thrombosis and haemostasis 1998;79(4):706-8.
1998: Jan P Vandenbroucke; Rogier M Bertina; Z R Holmes; C Spaargaren; J H van Krieken; B Manten; Pieter H Reitsma
Factor V Leiden and fatal pulmonary embolism.
Thrombosis and haemostasis 1998;79(3):511-6.
1997: E Gómez; swibertus rudolfus poort; Rogier M Bertina; Pieter H Reitsma
The usefulness of single-strand DNA conformation polymorphism analysis to detect mutations in protein C deficiency.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1997;8(8):497-502.
1997: Pieter H Reitsma
Protein C deficiency: from gene defects to disease.
Thrombosis and haemostasis 1997;78(1):344-50.
1997: Sophie Gandrille; Delphine Borgel; H Ireland; David A Lane; Rachel E Simmonds; Pieter H Reitsma; C Mannhalter; I Pabinger; H Saito; K Suzuki; C Formstone; D N Cooper; Y Espinosa; Núria Sala; francesco bernardi; Martine Aiach
Protein S deficiency: a database of mutations. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis.
Thrombosis and haemostasis 1997;77(6):1201-14.
1996: B Manten; R G Westendorp; T Koster; Pieter H Reitsma; F R Rosendaal
Risk factor profiles in patients with different clinical manifestations of venous thromboembolism: a focus on the factor V Leiden mutation.
Thrombosis and haemostasis 1996;76(4):510-3.