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Mary Relling

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Living Beings

Infant

Chemicals & Drugs

Procedures

Physiology

Occupations

Pharmacogenetics

Genes & Molecular Sequences

Single Nucleotide Polymorphism

Concepts & Ideas

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Publications

TOP 3
Treviño Lisa R; Yang Wenjian; French Deborah; Hunger Stephen P; Carroll William L; Devidas Meenakshi; Willman Cheryl; Neale Geoffrey; Downing James; Raimondi Susana C; Pui Ching-Hon; Evans William E; Relling Mary V
Germline genomic variants associated with childhood acute lymphoblastic leukemia.
Jeha S; Pei D; Raimondi S C; Onciu M; Campana D; Cheng C; Sandlund J T; Ribeiro R C; Rubnitz J E; Howard S C; Downing J R; Evans W E; Relling M V; Pui C-H
Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1.
Yang Jun; Bogni Alessia; Schuetz Erin G; Ratain Mark; Dolan M Eileen; McLeod Howard; Gong Li; Thorn Caroline; Relling Mary V; Klein Teri E; Altman Russ B
Etoposide pathway.

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All Publications

2009: Treviño Lisa R; Yang Wenjian; French Deborah; Hunger Stephen P; Carroll William L; Devidas Meenakshi; Willman Cheryl; Neale Geoffrey; Downing James; Raimondi Susana C; Pui Ching-Hon; Evans William E; Relling Mary V
Germline genomic variants associated with childhood acute lymphoblastic leukemia.
Nature genetics 2009;41(9):1001-5.
2009: Jeha S; Pei D; Raimondi S C; Onciu M; Campana D; Cheng C; Sandlund J T; Ribeiro R C; Rubnitz J E; Howard S C; Downing J R; Evans W E; Relling M V; Pui C-H
Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2009;23(8):1406-9.
2009: Yang Jun; Bogni Alessia; Schuetz Erin G; Ratain Mark; Dolan M Eileen; McLeod Howard; Gong Li; Thorn Caroline; Relling Mary V; Klein Teri E; Altman Russ B
Etoposide pathway.
Pharmacogenetics and genomics 2009;19(7):552-3.
2009: Pui Ching-Hon; Campana Dario; Pei Deqing; Bowman W Paul; Sandlund John T; Kaste Sue C; Ribeiro Raul C; Rubnitz Jeffrey E; Raimondi Susana C; Onciu Mihaela; Coustan-Smith Elaine; Kun Larry E; Jeha Sima; Cheng Cheng; Howard Scott C; Simmons Vickey; Bayles Amy; Metzger Monika L; Boyett James M; Leung Wing; Handgretinger Rupert; Downing James R; Evans William E; Relling Mary V
Treating childhood acute lymphoblastic leukemia without cranial irradiation.
The New England journal of medicine 2009;360(26):2730-41.
2009: French Deborah; Yang Wenjian; Cheng Cheng; Raimondi Susana C; Mullighan Charles G; Downing James R; Evans William E; Pui Ching-Hon; Relling Mary V
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
Blood 2009;113(19):4512-20.
2009: Gonzalez-Covarrubias Vanessa; Zhang Jianping; Kalabus James L; Relling Mary V; Blanco Javier G
Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):400-7.
2009: Yang Lei; Boyd Kelli; Kaste Sue C; Kamdem Kamdem Landry; Rahija Richard J; Relling Mary V
A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holiday.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009;27(2):169-75.
2009: Yang Jun J; Cheng Cheng; Yang Wenjian; Pei Deqing; Cao Xueyuan; Fan Yiping; Pounds Stanley B; Neale Geoffrey; Treviño Lisa R; French Deborah; Campana Dario; Downing James R; Evans William E; Pui Ching-Hon; Devidas Meenakshi; Bowman W P; Camitta Bruce M; Willman Cheryl L; Davies Stella M; Borowitz Michael J; Carroll William L; Hunger Stephen P; Relling Mary V
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
JAMA : the journal of the American Medical Association 2009;301(4):393-403.
2009: Mullighan Charles G; Su Xiaoping; Zhang Jinghui; Radtke Ina; Phillips Letha A A; Miller Christopher B; Ma Jing; Liu Wei; Cheng Cheng; Schulman Brenda A; Harvey Richard C; Chen I-Ming; Clifford Robert J; Carroll William L; Reaman Gregory; Bowman W Paul; Devidas Meenakshi; Gerhard Daniela S; Yang Wenjian; Relling Mary V; Shurtleff Sheila A; Campana Dario; Borowitz Michael J; Pui Ching-Hon; Smith Malcolm; Hunger Stephen P; Willman Cheryl L; Downing James R;
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.
The New England journal of medicine 2009;360(5):470-80.
2008: Yang Jun J; Bhojwani Deepa; Yang Wenjian; Cai Xiangjun; Stocco Gabriele; Crews Kristine; Wang Jinhua; Morrison Debra; Devidas Meenakshi; Hunger Stephen P; Willman Cheryl L; Raetz Elizabeth A; Pui Ching-Hon; Evans William E; Relling Mary V; Carroll William L
Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia.
Blood 2008;112(10):4178-83.
2008: Bhojwani Deepa; Kang Huining; Menezes Renee X; Yang Wenjian; Sather Harland; Moskowitz Naomi P; Min Dong-Joon; Potter Jeffrey W; Harvey Richard; Hunger Stephen P; Seibel Nita; Raetz Elizabeth A; Pieters Rob; Horstmann Martin A; Relling Mary V; den Boer Monique L; Willman Cheryl L; Carroll William L;
Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected].
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(27):4376-84.
2008: Krishnamurthy Partha; Schwab Matthias; Takenaka Kazumasa; Nachagari Deepa; Morgan Jessica; Leslie Mark; Du Weinan; Boyd Kelli; Cheok Meyling; Nakauchi Hiromitsu; Marzolini Catia; Kim Richard B; Poonkuzhali Balasubramanian; Schuetz Erin; Evans William; Relling Mary; Schuetz John D
Transporter-mediated protection against thiopurine-induced hematopoietic toxicity.
Cancer research 2008;68(13):4983-9.
2008: Jones Terreia S; Kaste Sue C; Liu Wei; Cheng Cheng; Yang Wenjian; Tantisira Kelan G; Pui Ching-Hon; Relling Mary V
CRHR1 polymorphisms predict bone density in survivors of acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(18):3031-7.
2008: Kamdem Landry K; Hamilton Leo; Cheng Cheng; Liu Wei; Yang Wenjian; Johnson Julie A; Pui Ching-Hon; Relling Mary V
Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.
Pharmacogenetics and genomics 2008;18(6):507-14.
2008: Blanco Javier G; Leisenring Wendy M; Gonzalez-Covarrubias Vanessa M; Kawashima Toana I; Davies Stella M; Relling Mary V; Robison Leslie L; Sklar Charles A; Stovall Marilyn; Bhatia Smita
Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer.
Cancer 2008;112(12):2789-95.
2008: Mullighan Charles G; Miller Christopher B; Radtke Ina; Phillips Letha A; Dalton James; Ma Jing; White Deborah; Hughes Timothy P; Le Beau Michelle M; Pui Ching-Hon; Relling Mary V; Shurtleff Sheila A; Downing James R
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.
Nature 2008;453(7191):110-4.
2008: Hijiya Nobuko; Stewart Clinton F; Zhou Yinmei; Campana Dario; Coustan-Smith Elaine; Rivera Gaston K; Relling Mary V; Pui Ching-Hon; Gajjar Amar
Phase II study of topotecan in combination with dexamethasone, asparaginase, and vincristine in pediatric patients with acute lymphoblastic leukemia in first relapse.
Cancer 2008;112(9):1983-91.
2008: French Deborah; Hamilton Leo H; Mattano Leonard A; Sather Harland N; Devidas Meenakshi; Nachman James B; Relling Mary V;
A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Blood 2008;111(9):4496-9.
2008: Yang Lei; Panetta John C; Cai Xiangjun; Yang Wenjian; Pei Deqing; Cheng Cheng; Kornegay Nancy; Pui Ching-Hon; Relling Mary V
Asparaginase may influence dexamethasone pharmacokinetics in acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(12):1932-9.
2008: Sorich Michael J; Pottier Nicolas; Pei Deqing; Yang Wenjian; Kager Leo; Stocco Gabriele; Cheng Cheng; Panetta John C; Pui Ching-Hon; Relling Mary V; Cheok Meyling H; Evans William E
In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.
PLoS medicine 2008;5(4):e83.
2008: Davies Stella M; Borowitz Michael J; Rosner Gary L; Ritz Kristin; Devidas Meenakshi; Winick Naomi; Martin Paul L; Bowman Paul; Elliott James; Willman Cheryl; Das Soma; Cook Edwin H; Relling Mary V
Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Blood 2008;111(6):2984-90.
2008: Pui Ching-Hon; Evans William E; Relling Mary V
Are children with lesser-risk B-lineage acute lymphoblastic leukemia curable with antimetabolite therapy?
Nature clinical practice. Oncology 2008;5(3):130-1.
2008: Relling Mary V; Evans William E; Pui Ching-Hon
Continue to study childhood ALL.
Blood 2008;111(1):468-9; author reply 469.
2008: French Deborah; Yang Wenjian; Hamilton Leo H; Neale Geoffrey; Fan Yiping; Downing James R; Cox Nancy J; Pui Ching-Hon; Evans William E; Relling Mary V
Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs.
PloS one 2008;3(5):e2144.
2007: Hartford C; Yang W; Cheng C; Fan Y; Liu W; Treviño L; Pounds S; Neale G; Raimondi S C; Bogni A; Dolan M E; Pui C-H; Relling M V
Genome scan implicates adhesion biological pathways in secondary leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(10):2128-36.
2007: Pottier Nicolas; Cheok Meyling H; Yang Wenjian; Assem Mahfoud; Tracey Lorraine; Obenauer John C; Panetta John C; Relling Mary V; Evans William E
Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression.
Human molecular genetics 2007;16(19):2261-71.
2007: Lewis Lionel D; Miller Antonius A; Rosner Gary L; Dowell Jonathan E; Valdivieso Manuel; Relling Mary V; Egorin Merrill J; Bies Robert R; Hollis Donna R; Levine Ellis G; Otterson Gregory A; Millard Frederick; Ratain Mark J;
A comparison of the pharmacokinetics and pharmacodynamics of docetaxel between African-American and Caucasian cancer patients: CALGB 9871.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3302-11.
2007: Hartford Christine; Vasquez Erick; Schwab Matthias; Edick Mathew J; Rehg Jerold E; Grosveld Gerard; Pui Ching-Hon; Evans William E; Relling Mary V
Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.
Cancer research 2007;67(10):4965-72.
2007: Altman Russ B; Benowitz Neal; Gurwitz David; Lunshof Jeantine; Relling Mary; Lamba Jatinder; Wieben Eric; Mooney Sean; Giacomini Kathleen; Weiss Scott; Johnson Julie A; McLeod Howard; Flockhart David; Weinshilboum Richard; Shuldiner Alan R; Roden Dan; Krauss Ronald M; Ratain Mark
Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing.
Pharmacogenomics 2007;8(5):519.
2007: Jones T S; Yang W; Evans W E; Relling M V
Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism.
Clinical pharmacology and therapeutics 2007;81(5):729-34.
2007: Kishi Shinji; Cheng Cheng; French Deborah; Pei Deqing; Das Soma; Cook Edwin H; Hijiya Nobuko; Rizzari Carmelo; Rosner Gary L; Frudakis Tony; Pui Ching-Hon; Evans William E; Relling Mary V
Ancestry and pharmacogenetics of antileukemic drug toxicity.
Blood 2007;109(10):4151-7.
2007: Mullighan Charles G; Goorha Salil; Radtke Ina; Miller Christopher B; Coustan-Smith Elaine; Dalton James D; Girtman Kevin; Mathew Susan; Ma Jing; Pounds Stanley B; Su Xiaoping; Pui Ching-Hon; Relling Mary V; Evans William E; Shurtleff Sheila A; Downing James R
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.
Nature 2007;446(7137):758-64.
2007: Hijiya Nobuko; Hudson Melissa M; Lensing Shelly; Zacher Margie; Onciu Mihaela; Behm Fred G; Razzouk Bassem I; Ribeiro Raul C; Rubnitz Jeffrey E; Sandlund John T; Rivera Gaston K; Evans William E; Relling Mary V; Pui Ching-Hon
Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia.
JAMA : the journal of the American Medical Association 2007;297(11):1207-15.
2007: Relling M V; Hoffman J M
Should pharmacogenomic studies be required for new drug approval?
Clinical pharmacology and therapeutics 2007;81(3):425-8.
2007: Steinberg Karen K; Relling Mary V; Gallagher Margaret L; Greene Christopher N; Rubin Carol S; French Deborah; Holmes Adrianne K; Carroll William L; Koontz Deborah A; Sampson Eric J; Satten Glen A
Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada.
Environmental health perspectives 2007;115(1):158-64.
2006: Pui Ching-Hon; Relling Mary V; Evans William E
Is mega dose of methotrexate beneficial to patients with acute lymphoblastic leukemia?
Leukemia & lymphoma 2006;47(12):2431-2.
2006: Hijiya Nobuko; Panetta John C; Zhou Yinmei; Kyzer Emily P; Howard Scott C; Jeha Sima; Razzouk Bassem I; Ribeiro Raul C; Rubnitz Jeffrey E; Hudson Melissa M; Sandlund John T; Pui Ching-Hon; Relling Mary V
Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia.
Blood 2006;108(13):3997-4002.
2006: Roden Dan M; Altman Russ B; Benowitz Neal L; Flockhart David A; Giacomini Kathleen M; Johnson Julie A; Krauss Ronald M; McLeod Howard L; Ratain Mark J; Relling Mary V; Ring Huijun Z; Shuldiner Alan R; Weinshilboum Richard M; Weiss Scott T;
Pharmacogenomics: challenges and opportunities.
Annals of internal medicine 2006;145(10):749-57.
2006: Cheng Qing; Cheng Cheng; Crews Kristine R; Ribeiro Raul C; Pui Ching-Hon; Relling Mary V; Evans William E
Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells.
American journal of human genetics 2006;79(2):264-74.
2006: Covarrubias Vanessa Gonzalez; Lakhman Sukhwinder S; Forrest Alan; Relling Mary V; Blanco Javier G
Higher activity of polymorphic NAD(P)H:quinone oxidoreductase in liver cytosols from blacks compared to whites.
Toxicology letters 2006;164(3):249-58.
2006: Lamba Jatinder K; Chen Xin; Lan Lu-Bin; Kim Jin Woo; Wei Wang Xin; Relling Mary V; Kazuto Yasuda; Watkins Paul B; Strom Stephen; Sun Daxi; Schuetz John D; Schuetz Erin G
Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans.
Pharmacogenetics and genomics 2006;16(6):415-27.
2006: Bogni A; Cheng C; Liu W; Yang W; Pfeffer J; Mukatira S; French D; Downing J R; Pui C-H; Relling M V
Genome-wide approach to identify risk factors for therapy-related myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(2):239-46.
2006: Relling Mary V; Pui Ching-Hon; Cheng Cheng; Evans William E
Thiopurine methyltransferase in acute lymphoblastic leukemia.
Blood 2006;107(2):843-4.
2005: Pui Ching-Hon; Pei Deqing; Sandlund John T; Campana Dario; Ribeiro Raul C; Razzouk Bassem I; Rubnitz Jeffrey E; Howard Scott C; Hijiya Nobuko; Jeha Sima; Cheng Cheng; Downing James R; Evans William E; Relling Mary V; Hudson Melissa
Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(31):7936-41.
2005: Laurie Nikia A; Gray Jonathan K; Zhang Jiakun; Leggas Mark; Relling Mary; Egorin Merrill; Stewart Clinton; Dyer Michael A
Topotecan combination chemotherapy in two new rodent models of retinoblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(20):7569-78.
2005: Zaza Gianluigi; Cheok Meyling; Yang Wenjian; Panetta John C; Pui Ching-Hon; Relling Mary V; Evans William E
Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment.
Blood 2005;106(5):1778-85.
2005: Cheng Qing; Yang WenJian; Raimondi Susana C; Pui Ching-Hon; Relling Mary V; Evans William E
Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes.
Nature genetics 2005;37(8):878-82.
2005: Hijiya N; Liu W; Sandlund J T; Jeha S; Razzouk B I; Ribeiro R C; Rubnitz J E; Howard S C; Kyzer E P; Redd D S; Cheng C; Rivera G K; Hudson M M; Relling M V; Pui C-H
Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: lack of therapeutic role of local irradiation.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(8):1399-403.
2005: French Deborah; Wilkinson Mark R; Yang Wenjian; de Chaisemartin Luc; Cook Edwin H; Das Soma; Ratain Mark J; Evans William E; Downing James R; Pui Ching-Hon; Relling Mary V
Global gene expression as a function of germline genetic variation.
Human molecular genetics 2005;14(12):1621-9.
2005: Rocha Jose Claudio C; Cheng Cheng; Liu Wei; Kishi Shinji; Das Soma; Cook Edwin H; Sandlund John T; Rubnitz Jeffrey; Ribeiro Raul; Campana Dario; Pui Ching-Hon; Evans William E; Relling Mary V
Pharmacogenetics of outcome in children with acute lymphoblastic leukemia.
Blood 2005;105(12):4752-8.
2005: Lugthart Sanne; Cheok Meyling H; den Boer Monique L; Yang Wenjian; Holleman Amy; Cheng Cheng; Pui Ching-Hon; Relling Mary V; Janka-Schaub Gritta E; Pieters Rob; Evans William E
Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.
Cancer cell 2005;7(4):375-86.
2005: Edick Mathew J; Cheng Cheng; Yang Wenjian; Cheok Meyling; Wilkinson Mark R; Pei Deqing; Evans William E; Kun Larry E; Pui Ching-Hon; Relling Mary V
Lymphoid gene expression as a predictor of risk of secondary brain tumors.
Genes, chromosomes & cancer 2005;42(2):107-16.
2005: Kager Leo; Cheok Meyling; Yang Wenjian; Zaza Gianluigi; Cheng Qing; Panetta John C; Pui Ching-Hon; Downing James R; Relling Mary V; Evans William E
Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.
The Journal of clinical investigation 2005;115(1):110-7.
2005: Rivera Gaston K; Zhou Yinmei; Hancock Michael L; Gajjar Amar; Rubnitz Jeffrey; Ribeiro Raul C; Sandlund John T; Hudson Melissa; Relling Mary; Evans William E; Pui Ching-Hon
Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia.
Cancer 2005;103(2):368-76.
2004: Pui Ching-Hon; Sandlund John T; Pei Deqing; Campana Dario; Rivera Gaston K; Ribeiro Raul C; Rubnitz Jeffrey E; Razzouk Bassem I; Howard Scott C; Hudson Melissa M; Cheng Cheng; Kun Larry E; Raimondi Susana C; Behm Frederick G; Downing James R; Relling Mary V; Evans William E;
Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital.
Blood 2004;104(9):2690-6.
2004: Relling Mary V; Yang Wenjian; Das Soma; Cook Edwin H; Rosner Gary L; Neel Michael; Howard Scott; Ribeiro Raul; Sandlund John T; Pui Ching-Hon; Kaste Sue C
Pharmacogenetic risk factors for osteonecrosis of the hip among children with leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(19):3930-6.
2004: Hijiya N; Gajjar A; Zhang Z; Sandlund J T; Ribeiro R C; Rubnitz J E; Jeha S; Liu W; Cheng C; Raimondi S C; Behm F G; Rivera G K; Relling M V; Pui C-H
Low-dose oral etoposide-based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(10):1581-6.
2004: Pui Ching-Hon; Relling Mary V
Can the genotoxicity of chemotherapy be predicted?
Lancet 2004;364(9438):917-8.
2004: Ramírez Jacqueline; Innocenti Federico; Schuetz Erin G; Flockhart David A; Relling Mary V; Santucci Raymond; Ratain Mark J
CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(9):930-6.
2004: Zaza Gianluigi; Yang Wenjian; Kager Leo; Cheok Meyling; Downing James; Pui Ching-Hon; Cheng Cheng; Relling Mary V; Evans William E
Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis.
Blood 2004;104(5):1435-41.
2004: Holleman Amy; Cheok Meyling H; den Boer Monique L; Yang Wenjian; Veerman Anjo J P; Kazemier Karin M; Pei Deqing; Cheng Cheng; Pui Ching-Hon; Relling Mary V; Janka-Schaub Gritta E; Pieters Rob; Evans William E
Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment.
The New England journal of medicine 2004;351(6):533-42.
2004: Cheng Qing; Wu Bainan; Kager Leo; Panetta J Carl; Zheng Jie; Pui Ching-Hon; Relling Mary V; Evans William E
A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells.
Pharmacogenetics 2004;14(8):557-67.
2004: Pauley Jennifer L; Panetta John Carl; Schmidt Jeffrey; Kornegay Nancy; Relling Mary V; Pui Ching-Hon
Late-onset delayed excretion of methotrexate.
Cancer chemotherapy and pharmacology 2004;54(2):146-52.
2004: Hak L J; Relling M V; Cheng C; Pei D; Wang B; Sandlund J T; Rubnitz J; Pui C-H
Asparaginase pharmacodynamics differ by formulation among children with newly diagnosed acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(6):1072-7.
2004: Evans William E; Relling Mary V
Moving towards individualized medicine with pharmacogenomics.
Nature 2004;429(6990):464-8.
2004: Pui Ching-Hon; Relling Mary V; Downing James R
Acute lymphoblastic leukemia.
The New England journal of medicine 2004;350(15):1535-48.
2004: Blanco Javier G; Edick Mathew J; Relling Mary V
Etoposide induces chimeric Mll gene fusions.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):173-5.
2004: Kishi Shinji; Yang Wenjian; Boureau Benoit; Morand Stanislas; Das Soma; Chen Peixian; Cook Edwin H; Rosner Gary L; Schuetz Erin; Pui Ching-Hon; Relling Mary V
Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia.
Blood 2004;103(1):67-72.
2003: Pui Ching-Hon; Sandlund John T; Pei Deqing; Rivera Gaston K; Howard Scott C; Ribeiro Raul C; Rubnitz Jeffrey E; Razzouk Bassem I; Hudson Melissa M; Cheng Cheng; Raimondi Susana C; Behm Frederick G; Downing James R; Relling Mary V; Evans William E
Results of therapy for acute lymphoblastic leukemia in black and white children.
JAMA : the journal of the American Medical Association 2003;290(15):2001-7.
2003: Pui Ching-Hon; Cheng Cheng; Leung Wing; Rai Shesh N; Rivera Gaston K; Sandlund John T; Ribeiro Raul C; Relling Mary V; Kun Larry E; Evans William E; Hudson Melissa M
Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia.
The New England journal of medicine 2003;349(7):640-9.
2003: Kishi Shinji; Griener James; Cheng Cheng; Das Soma; Cook Edwin H; Pei Deqing; Hudson Melissa; Rubnitz Jeffrey; Sandlund John T; Pui Ching-Hon; Relling Mary V
Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(16):3084-91.
2003: Wang B; Relling M V; Storm M C; Woo M H; Ribeiro R; Pui C-H; Hak L J
Evaluation of immunologic crossreaction of antiasparaginase antibodies in acute lymphoblastic leukemia (ALL) and lymphoma patients.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(8):1583-8.
2003: Echlin-Bell Deborah R; Smith Lydia L; Li Loretta; Strissel Pamela L; Strick Reiner; Gupta Vandana; Banerjee Jhula; Larson Richard; Relling Mary V; Raimondi Susan C; Hayashi Yasuhide; Taki Tomohiko; Zeleznik-Le Nancy; Rowley Janet D
Polymorphisms in the MLL breakpoint cluster region (BCR).
Human genetics 2003;113(1):80-91.
2003: Dervieux Thierry; Hancock Michael L; Pui Ching-Hon; Rivera Gaston K; Sandlund John T; Ribeiro Raul C; Boyett James; Evans William E; Relling Mary V
Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia.
Clinical pharmacology and therapeutics 2003;73(6):506-16.
2003: Cheok Meyling H; Yang Wenjian; Pui Ching-Hon; Downing James R; Cheng Cheng; Naeve Clayton W; Relling Mary V; Evans William E
Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells.
Nature genetics 2003;34(1):85-90.
2003: Relling Mary V; Boyett James M; Blanco Javier G; Raimondi Susana; Behm Frederick G; Sandlund John T; Rivera Gaston K; Kun Larry E; Evans William E; Pui Ching-Hon
Granulocyte colony-stimulating factor and the risk of secondary myeloid malignancy after etoposide treatment.
Blood 2003;101(10):3862-7.
2003: Edick Mathew J; Gajjar Amar; Mahmoud Hazem H; van de Poll Matthijs E C; Harrison Patricia L; Panetta John C; Rivera Gaston K; Ribeiro Raul C; Sandlund John T; Boyett James M; Pui Ching-Hon; Relling Mary V
Pharmacokinetics and pharmacodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(7):1340-6.
2003: Carroll William L; Bhojwani Deepa; Min Dong-Joon; Raetz Elizabeth; Relling Mary; Davies Stella; Downing James R; Willman Cheryl L; Reed John C
Pediatric acute lymphoblastic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003;():102-31.
2002: Pui Ching Hon; Relling Mary V; Evans William E
Role of pharmacogenomics and pharmacodynamics in the treatment of acute lymphoblastic leukaemia.
Best practice & research. Clinical haematology 2002;15(4):741-56.
2002: Panetta John Carl; Yanishevski Yuri; Pui Ching-Hon; Sandlund John T; Rubnitz Jeffrey; Rivera Gaston K; Ribeiro Raul; Evans William E; Relling Mary V
A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia.
Cancer chemotherapy and pharmacology 2002;50(5):419-28.
2002: Blanco Javier G; Edick Mathew J; Hancock Michael L; Winick Naomi J; Dervieux Thierry; Amylon Michael D; Bash Robert O; Behm Frederick G; Camitta Bruce M; Pui Ching-Hon; Raimondi Susana C; Relling Mary V
Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies.
Pharmacogenetics 2002;12(8):605-11.
2002: Dervieux Thierry; Brenner Timothy L; Hon Yuen Y; Zhou Yinmei; Hancock Michael L; Sandlund John T; Rivera Gaston K; Ribeiro Raul C; Boyett James M; Pui Ching-Hon; Relling Mary V; Evans William E
De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo.
Blood 2002;100(4):1240-7.
2002: Panetta John Carl; Wall Amelia; Pui Ching-Hon; Relling Mary V; Evans William E
Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2423-9.
2002: Sandlund John T; Harrison Patricia L; Rivera Gaston; Behm Frederick G; Head David; Boyett James; Rubnitz Jeffrey E; Gajjar Amar; Raimondi Susana; Ribeiro Raul; Hudson Melissa; Relling Mary; Evans William; Pui Ching-Hon
Persistence of lymphoblasts in bone marrow on day 15 and days 22 to 25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia.
Blood 2002;100(1):43-7.
2002: Pui Ching-Hon; Relling Mary V; Campana Dario; Evans William E
Childhood acute lymphoblastic leukemia.
Reviews in clinical and experimental hematology 2002;6(2):161-80; discussion 200-2.
2002: Panetta John Carl; Wilkinson Mark; Pui Ching-Hon; Relling Mary V
Limited and optimal sampling strategies for etoposide and etoposide catechol in children with leukemia.
Journal of pharmacokinetics and pharmacodynamics 2002;29(2):171-88.
2002: Yeoh Eng-Juh; Ross Mary E; Shurtleff Sheila A; Williams W Kent; Patel Divyen; Mahfouz Rami; Behm Fred G; Raimondi Susana C; Relling Mary V; Patel Anami; Cheng Cheng; Campana Dario; Wilkins Dawn; Zhou Xiaodong; Li Jinyan; Liu Huiqing; Pui Ching-Hon; Evans William E; Naeve Clayton; Wong Limsoon; Downing James R
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
Cancer cell 2002;1(2):133-43.
2002: Dervieux T; Hancock M; Evans W; Pui C-H; Relling M V
Effect of methotrexate polyglutamates on thioguanine nucleotide concentrations during continuation therapy of acute lymphoblastic leukemia with mercaptopurine.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(2):209-12.
2002: Dervieux Thierry; Chu Yaqin; Su Yi; Pui Ching-Hon; Evans William E; Relling Mary V
HPLC determination of thiopurine nucleosides and nucleotides in vivo in lymphoblasts following mercaptopurine therapy.
Clinical chemistry 2002;48(1):61-8.
2002: Hoelzer Dieter; Gökbuget Nicola; Ottmann Oliver; Pui Ching-Hon; Relling Mary V; Appelbaum Frederick R; van Dongen Jacques J M; Szczepanski Tomasz
Acute lymphoblastic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2002;():162-92.
2001: Relling M V; Dervieux T
Pharmacogenetics and cancer therapy.
Nature reviews. Cancer 2001;1(2):99-108.
2001: Zhang J; Kuehl P; Green E D; Touchman J W; Watkins P B; Daly A; Hall S D; Maurel P; Relling M; Brimer C; Yasuda K; Wrighton S A; Hancock M; Kim R B; Strom S; Thummel K; Russell C G; Hudson J R; Schuetz E G; Boguski M S
The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.
Pharmacogenetics 2001;11(7):555-72.
2001: Blanco J G; Dervieux T; Edick M J; Mehta P K; Rubnitz J E; Shurtleff S; Raimondi S C; Behm F G; Pui C H; Relling M V
Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10338-43.
2001: Dervieux T; Blanco J G; Krynetski E Y; Vanin E F; Roussel M F; Relling M V
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.
Cancer research 2001;61(15):5810-6.
2001: van de Poll M E; Relling M V; Schuetz E G; Harrison P L; Hughes W; Flynn P M
The effect of atovaquone on etoposide pharmacokinetics in children with acute lymphoblastic leukemia.
Cancer chemotherapy and pharmacology 2001;47(6):467-72.
2001: Ribeiro R C; Fletcher B D; Kennedy W; Harrison P L; Neel M D; Kaste S C; Sandlund J T; Rubnitz J E; Razzouk B I; Relling M V; Pui C H
Magnetic resonance imaging detection of avascular necrosis of the bone in children receiving intensive prednisone therapy for acute lymphoblastic leukemia or non-Hodgkin lymphoma.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(6):891-7.
2001: Pui C H; Sallan S; Relling M V; Masera G; Evans W E
International Childhood Acute Lymphoblastic Leukemia Workshop: Sausalito, CA, 30 November-1 December 2000.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(5):707-15.
2001: Evans W E; Hon Y Y; Bomgaars L; Coutre S; Holdsworth M; Janco R; Kalwinsky D; Keller F; Khatib Z; Margolin J; Murray J; Quinn J; Ravindranath Y; Ritchey K; Roberts W; Rogers Z R; Schiff D; Steuber C; Tucci F; Kornegay N; Krynetski E Y; Relling M V
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(8):2293-301.
2001: Kuehl P; Zhang J; Lin Y; Lamba J; Assem M; Schuetz J; Watkins P B; Daly A; Wrighton S A; Hall S D; Maurel P; Relling M; Brimer C; Yasuda K; Venkataramanan R; Strom S; Thummel K; Boguski M S; Schuetz E
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.
Nature genetics 2001;27(4):383-91.
2001: Pui C H; Mahmoud H H; Wiley J M; Woods G M; Leverger G; Camitta B; Hastings C; Blaney S M; Relling M V; Reaman G H
Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients With leukemia or lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(3):697-704.
2000: Pui C H; Boyett J M; Rivera G K; Hancock M L; Sandlund J T; Ribeiro R C; Rubnitz J E; Behm F G; Raimondi S C; Gajjar A; Razzouk B; Campana D; Kun L E; Relling M V; Evans W E
Long-term results of Total Therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children's Research Hospital.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(12):2286-94.
2000: Gajjar A; Harrison P L; Sandlund J T; Rivera G K; Ribeiro R C; Rubnitz J E; Razzouk B; Relling M V; Evans W E; Boyett J M; Pui C H
Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemia.
Blood 2000;96(10):3381-4.
2000: Johnson J A; Herring V L; Wolfe M S; Relling M V
CYP1A2 and CYP2D6 4-hydroxylate propranolol and both reactions exhibit racial differences.
The Journal of pharmacology and experimental therapeutics 2000;294(3):1099-105.
2000: Relling M V; Pui C H; Sandlund J T; Rivera G K; Hancock M L; Boyett J M; Schuetz E G; Evans W E
Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia.
Lancet 2000;356(9226):285-90.
2000: Brimer C; Dalton J T; Zhu Z; Schuetz J; Yasuda K; Vanin E; Relling M V; Lu Y; Schuetz E G
Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein.
Pharmaceutical research 2000;17(7):803-10.
2000: Wang B; Hak L J; Relling M V; Pui C H; Woo M H; Storm M C
ELISA to evaluate plasma anti-asparaginase IgG concentrations in patients with acute lymphoblastic leukemia.
Journal of immunological methods 2000;239(1-2):75-83.
2000: Pui C H; Relling M V
Topoisomerase II inhibitor-related acute myeloid leukaemia.
British journal of haematology 2000;109(1):13-23.
2000: Woo M H; Hak L J; Storm M C; Sandlund J T; Ribeiro R C; Rivera G K; Rubnitz J E; Harrison P L; Wang B; Evans W E; Pui C H; Relling M V
Hypersensitivity or development of antibodies to asparaginase does not impact treatment outcome of childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(7):1525-32.
2000: Blanco J G; Harrison P L; Evans W E; Relling M V
Human cytochrome P450 maximal activities in pediatric versus adult liver.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):379-82.
2000: Woo M H; Shuster J J; Chen C; Bash R O; Behm F G; Camitta B; Felix C A; Kamen B A; Pui C H; Raimondi S C; Winick N J; Amylon M D; Relling M V
Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid malignancies.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(2):232-7.
2000: Wall A M; Gajjar A; Link A; Mahmoud H; Pui C H; Relling M V
Individualized methotrexate dosing in children with relapsed acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(2):221-5.
2000: Schuetz E G; Umbenhauer D R; Yasuda K; Brimer C; Nguyen L; Relling M V; Schuetz J D; Schinkel A H
Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes.
Molecular pharmacology 2000;57(1):188-97.
1999: Relling M V; Hancock M L; Rivera G K; Sandlund J T; Ribeiro R C; Krynetski E Y; Pui C H; Evans W E
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
Journal of the National Cancer Institute 1999;91(23):2001-8.
1999: Evans W E; Relling M V
Pharmacogenomics: translating functional genomics into rational therapeutics.
Science (New York, N.Y.) 1999;286(5439):487-91.
1999: Su Y; Hon Y Y; Chu Y; Van de Poll M E; Relling M V
Assay of 6-mercaptopurine and its metabolites in patient plasma by high-performance liquid chromatography with diode-array detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;732(2):459-68.
1999: Relling M V; Rubnitz J E; Rivera G K; Boyett J M; Hancock M L; Felix C A; Kun L E; Walter A W; Evans W E; Pui C H
High incidence of secondary brain tumours after radiotherapy and antimetabolites.
Lancet 1999;354(9172):34-9.
1999: Cai X; Woo M H; Edick M J; Relling M V
Simultaneous quantitation of etoposide and its catechol metabolite in human plasma using high-performance liquid chromatography with electrochemical detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;728(2):241-50.
1999: Woo M H; Hak L J; Storm M C; Gajjar A J; Sandlund J T; Harrison P L; Wang B; Pui C H; Relling M V
Cerebrospinal fluid asparagine concentrations after Escherichia coli asparaginase in children with acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(5):1568-73.
1999: Relling M V; Hancock M L; Boyett J M; Pui C H; Evans W E
Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia.
Blood 1999;93(9):2817-23.
1999: Woo M H; Relling M V; Sonnichsen D S; Rivera G K; Pratt C B; Pui C H; Evans W E; Pappo A S
Phase I targeted systemic exposure study of paclitaxel in children with refractory acute leukemias.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):543-9.
1999: Pui C H; Boyett J M; Relling M V; Harrison P L; Rivera G K; Behm F G; Sandlund J T; Ribeiro R C; Rubnitz J E; Gajjar A; Evans W E
Sex differences in prognosis for children with acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(3):818-24.
1999: Belkov V M; Krynetski E Y; Schuetz J D; Yanishevski Y; Masson E; Mathew S; Raimondi S; Pui C H; Relling M V; Evans W E
Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation.
Blood 1999;93(5):1643-50.
1999: Hon Y Y; Fessing M Y; Pui C H; Relling M V; Krynetski E Y; Evans W E
Polymorphism of the thiopurine S-methyltransferase gene in African-Americans.
Human molecular genetics 1999;8(2):371-6.
1999: Rubnitz J E; Behm F G; Wichlan D; Ryan C; Sandlund J T; Ribeiro R C; Rivera G K; Hancock M L; Relling M V; Evans W E; Pui C H; Downing J R
Low frequency of TEL-AML1 in relapsed acute lymphoblastic leukemia supports a favorable prognosis for this genetic subgroup.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(1):19-21.
1999: Evans W E; Pui C H; Relling M V
Defining the optimal dosage of methotrexate for childhood acute lymphoblastic leukemia. New insights from the lab and clinic.
Advances in experimental medicine and biology 1999;457():537-41.
1999: Woo M H; Gregornik D; Shearer P D; Meyer W H; Relling M V
Pharmacokinetics of paclitaxel in an anephric patient.
Cancer chemotherapy and pharmacology 1999;43(1):92-6.
1998: Pui C H; Rubnitz J E; Hancock M L; Downing J R; Raimondi S C; Rivera G K; Sandlund J T; Ribeiro R C; Head D R; Relling M V; Evans W E; Behm F G
Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(12):3768-73.
1998: Woo M H; Hak L J; Storm M C; Evans W E; Sandlund J T; Rivera G K; Wang B; Pui C H; Relling M V
Anti-asparaginase antibodies following E. coli asparaginase therapy in pediatric acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(10):1527-33.
1998: Rubnitz J E; Relling M V; Harrison P L; Sandlund J T; Ribeiro R C; Rivera G K; Thompson S J; Evans W E; Pui C H
Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(8):1176-81.
1998: Chen C L; Woo M H; Neale G A; Goorha R M; Fuscoe J C; Behm F G; Mathew S; Relling M V
A human lymphoid leukemia cell line with a V(D)J recombinase-mediated deletion of hprt.
Mutation research 1998;403(1-2):113-25.
1998: Loennechen T; Yates C R; Fessing M Y; Relling M V; Krynetski E Y; Evans W E
Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans.
Clinical pharmacology and therapeutics 1998;64(1):46-51.
1998: Pui C H; Mahmoud H H; Rivera G K; Hancock M L; Sandlund J T; Behm F G; Head D R; Relling M V; Ribeiro R C; Rubnitz J E; Kun L E; Evans W E
Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia.
Blood 1998;92(2):411-5.
1998: Relling M V; Yanishevski Y; Nemec J; Evans W E; Boyett J M; Behm F G; Pui C H
Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(3):346-52.
1998: Evans W E; Relling M V; Rodman J H; Crom W R; Boyett J M; Pui C H
Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia.
The New England journal of medicine 1998;338(8):499-505.
1997: Pui C H; Relling M V; Lascombes F; Harrison P L; Struxiano A; Mondesir J M; Ribeiro R C; Sandlund J T; Rivera G K; Evans W E; Mahmoud H H
Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(11):1813-6.
1997: Rubnitz J E; Behm F G; Pui C H; Evans W E; Relling M V; Raimondi S C; Harrison P L; Sandlund J T; Ribeiro R C; Grosveld G; Downing J R
Genetic studies of childhood acute lymphoblastic leukemia with emphasis on p16, MLL, and ETV6 gene abnormalities: results of St Jude Total Therapy Study XII.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(8):1201-6.
1997: Galpin A J; Schuetz J D; Masson E; Yanishevski Y; Synold T W; Barredo J C; Pui C H; Relling M V; Evans W E
Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity.
Molecular pharmacology 1997;52(1):155-63.
1997: Evans W E; Relling M V; Boyett J M; Pui C H
Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can we learn from small studies?
Leukemia research 1997;21(5):435-7.
1997: Yates C R; Krynetski E Y; Loennechen T; Fessing M Y; Tai H L; Pui C H; Relling M V; Evans W E
Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.
Annals of internal medicine 1997;126(8):608-14.
1997: Chen C L; Liu Q; Pui C H; Rivera G K; Sandlund J T; Ribeiro R; Evans W E; Relling M V
Higher frequency of glutathione S-transferase deletions in black children with acute lymphoblastic leukemia.
Blood 1997;89(5):1701-7.
1997: Chen C L; Liu Q; Evans W E; Sander C H; Relling M V
Cytochrome P450 2D6 and glutathione S-transferase genotype in sudden infant death syndrome.
Journal of paediatrics and child health 1997;33(1):31-7.
1996: Chen C L; Fuscoe J C; Liu Q; Pui C H; Mahmoud H H; Relling M V
Relationship between cytotoxicity and site-specific DNA recombination after in vitro exposure of leukemia cells to etoposide.
Journal of the National Cancer Institute 1996;88(24):1840-7.
1996: Bosso J A; Liu Q; Evans W E; Relling M V
CYP2D6, N-acetylation, and xanthine oxidase activity in cystic fibrosis.
Pharmacotherapy 1996;16(5):749-53.
1996: Chen C L; Fuscoe J C; Liu Q; Relling M V
Etoposide causes illegitimate V(D)J recombination in human lymphoid leukemic cells.
Blood 1996;88(6):2210-8.
1996: Krynetski E Y; Tai H L; Yates C R; Fessing M Y; Loennechen T; Schuetz J D; Relling M V; Evans W E
Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.
Pharmacogenetics 1996;6(4):279-90.
1996: Chen C L; Liu Q; Relling M V
Simultaneous characterization of glutathione S-transferase M1 and T1 polymorphisms by polymerase chain reaction in American whites and blacks.
Pharmacogenetics 1996;6(2):187-91.
1996: Schuetz E G; Schinkel A H; Relling M V; Schuetz J D
P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4001-5.
1996: Relling M V; Mahmoud H H; Pui C H; Sandlund J T; Rivera G K; Ribeiro R C; Crist W M; Evans W E
Etoposide achieves potentially cytotoxic concentrations in CSF of children with acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(2):399-404.
1996: Masson E; Synold T W; Relling M V; Schuetz J D; Sandlund J T; Pui C H; Evans W E
Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(1):56-60.
1996: Masson E; Relling M V; Synold T W; Liu Q; Schuetz J D; Sandlund J T; Pui C H; Evans W E
Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.
The Journal of clinical investigation 1996;97(1):73-80.
1995: Pui C H; Relling M V; Rivera G K; Hancock M L; Raimondi S C; Heslop H E; Santana V M; Ribeiro R C; Sandlund J T; Mahmoud H H
Epipodophyllotoxin-related acute myeloid leukemia: a study of 35 cases.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(12):1990-6.
1995: Sonnichsen D S; Liu Q; Schuetz E G; Schuetz J D; Pappo A; Relling M V
Variability in human cytochrome P450 paclitaxel metabolism.
The Journal of pharmacology and experimental therapeutics 1995;275(2):566-75.
1995: Pui C H; Relling M V; Behm F G; Hancock M L; Boyett J M; Raimondi S C; Krance R A; Mahmoud H H; Ribeiro R C; Sandlund J T
L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(10):1680-4.
1995: Sonnichsen D S; Ribeiro R C; Luo X; Mathew P; Relling M V
Pharmacokinetics and pharmacodynamics of 21-day continuous oral etoposide in pediatric patients with solid tumors.
Clinical pharmacology and therapeutics 1995;58(1):99-107.
1995: McLeod H L; Relling M V; Liu Q; Pui C H; Evans W E
Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia.
Blood 1995;85(7):1897-902.
1995: Krynetski E Y; Schuetz J D; Galpin A J; Pui C H; Relling M V; Evans W E
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):949-53.
1994: Evans W E; Relling M V
Mercaptopurine vs thioguanine for the treatment of acute lymphoblastic leukemia.
Leukemia research 1994;18(11):811-4.
1994: Relling M V; McLeod H L; Bowman L C; Santana V M
Etoposide pharmacokinetics and pharmacodynamics after acute and chronic exposure to cisplatin.
Clinical pharmacology and therapeutics 1994;56(5):503-11.
1994: Synold T W; Relling M V; Boyett J M; Rivera G K; Sandlund J T; Mahmoud H; Crist W M; Pui C H; Evans W E
Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.
The Journal of clinical investigation 1994;94(5):1996-2001.
1994: Sonnichsen D S; Relling M V
Clinical pharmacokinetics of paclitaxel.
Clinical pharmacokinetics 1994;27(4):256-69.
1994: Mathew P; Ribeiro R C; Sonnichsen D; Relling M; Pratt C; Mahmoud H; Bowman L; Meyer W; Avery L; Crist W
Phase I study of oral etoposide in children with refractory solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(7):1452-7.
1994: Barredo J C; Synold T W; Laver J; Relling M V; Pui C H; Priest D G; Evans W E
Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia.
Blood 1994;84(2):564-9.
1994: Sonnichsen D S; Hurwitz C A; Pratt C B; Shuster J J; Relling M V
Saturable pharmacokinetics and paclitaxel pharmacodynamics in children with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(3):532-8.
1994: Relling M V; Nemec J; Schuetz E G; Schuetz J D; Gonzalez F J; Korzekwa K R
O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.
Molecular pharmacology 1994;45(2):352-8.
1993: Hurwitz C A; Relling M V; Weitman S D; Ravindranath Y; Vietti T J; Strother D R; Ragab A H; Pratt C B
Phase I trial of paclitaxel in children with refractory solid tumors: a Pediatric Oncology Group Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(12):2324-9.
1993: Relling M V; Mulhern R K; Fairclough D; Baker D; Pui C H
Chlorpromazine with and without lorazepam as antiemetic therapy in children receiving uniform chemotherapy.
The Journal of pediatrics 1993;123(5):811-6.
1993: Evans W E; Relling M V; Rahman A; McLeod H L; Scott E P; Lin J S
Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans.
The Journal of clinical investigation 1993;91(5):2150-4.
1993: Rodman J H; Relling M V; Stewart C F; Synold T W; McLeod H; Kearns C; Stute N; Crom W R; Evans W E
Clinical pharmacokinetics and pharmacodynamics of anticancer drugs in children.
Seminars in oncology 1993;20(1):18-29.
1992: Relling M V; Lin J S; Ayers G D; Evans W E
Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities.
Clinical pharmacology and therapeutics 1992;52(6):643-58.
1992: Relling M V; Evans R; Dass C; Desiderio D M; Nemec J
Human cytochrome P450 metabolism of teniposide and etoposide.
The Journal of pharmacology and experimental therapeutics 1992;261(2):491-6.
1992: Baker D K; Relling M V; Pui C H; Christensen M L; Evans W E; Rodman J H
Increased teniposide clearance with concomitant anticonvulsant therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992;10(2):311-5.
1992: Evans W E; Rodman J H; Relling M V; Petros W P; Stewart C F; Pui C H; Rivera G K
Differences in teniposide disposition and pharmacodynamics in patients with newly diagnosed and relapsed acute lymphocytic leukemia.
The Journal of pharmacology and experimental therapeutics 1992;260(1):71-7.
1992: Petros W P; Rodman J H; Relling M V; Christensen M; Pui C H; Rivera G K; Evans W E
Variability in teniposide plasma protein binding is correlated with serum albumin concentrations.
Pharmacotherapy 1992;12(4):273-7.
1991: Evans W E; Relling M V
Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers.
Pharmacogenetics 1991;1(3):143-8.
1991: Relling M V; Cherrie J; Schell M J; Petros W P; Meyer W H; Evans W E
Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects.
Clinical pharmacology and therapeutics 1991;50(3):308-13.
1991: Crom W R; Relling M V; Christensen M L; Rivera G K; Evans W E
Age-related differences in hepatic drug clearance in children: studies with lorazepam and antipyrine.
Clinical pharmacology and therapeutics 1991;50(2):132-40.
1990: Evans W E; Relling M V
Xbal 16- plus 9-kilobase DNA restriction fragments identify a mutant allele for debrisoquin hydroxylase: report of a family study.
Molecular pharmacology 1990;37(5):639-42.
1990: Kalwinsky D K; Raimondi S C; Bunin N J; Fairclough D; Pui C H; Relling M V; Ribeiro R; Rivera G K
Clinical and biological characteristics of acute lymphocytic leukemia in children with Down syndrome.
American journal of medical genetics. Supplement 1990;7():267-71.
1989: Evans W E; Petros W P; Relling M V; Crom W R; Madden T; Rodman J H; Sunderland M
Clinical pharmacology of cancer chemotherapy in children.
Pediatric clinics of North America 1989;36(5):1199-230.
1989: Evans W E; Relling M V; de Graaf S; Rodman J H; Pieper J A; Christensen M L; Crom W R
Hepatic drug clearance in children: studies with indocyanine green as a model substrate.
Journal of pharmaceutical sciences 1989;78(6):452-6.
1989: Evans W E; Relling M V; Petros W P; Meyer W H; Mirro J; Crom W R
Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in children.
Clinical pharmacology and therapeutics 1989;45(5):568-73.
1989: Relling M V; Mulhern R K; Dodge R K; Johnson D; Pieper J A; Rivera G K; Evans W E
Lorazepam pharmacodynamics and pharmacokinetics in children.
The Journal of pediatrics 1989;114(4 Pt 1):641-6.
1988: Relling M V; Stapleton F B; Ochs J; Jones D P; Meyer W; Wainer I W; Crom W R; McKay C P; Evans W E
Removal of methotrexate, leucovorin, and their metabolites by combined hemodialysis and hemoperfusion.
Cancer 1988;62(5):884-8.
1987: Garré M L; Relling M V; Kalwinsky D; Dodge R; Crom W R; Abromowitch M; Pui C H; Evans W E
Pharmacokinetics and toxicity of methotrexate in children with Down syndrome and acute lymphocytic leukemia.
The Journal of pediatrics 1987;111(4):606-12.
1987: Crom W R; Webster S L; Bobo L; Teresi M E; Relling M V; Evans W E
Simultaneous administration of multiple model substrates to assess hepatic drug clearance.
Clinical pharmacology and therapeutics 1987;41(6):645-50.
1987: Crom W R; Glynn-Barnhart A M; Rodman J H; Teresi M E; Kavanagh R E; Christensen M L; Relling M V; Evans W E
Pharmacokinetics of anticancer drugs in children.
Clinical pharmacokinetics 1987;12(3):168-213.
1987: Evans W E; Abromowitch M; Crom W R; Relling M V; Bowman W P; Pui C H; Ochs J; Dodge R
Clinical pharmacodynamic studies of high-dose methotrexate in acute lymphocytic leukemia.
NCI monographs : a publication of the National Cancer Institute 1987;(5):81-5.

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