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William Remers

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
18
Dorr, Robert
14
Sami, SM
4
Alberts, David
3
Iyengar, Bhashyam
2
Einspahr, Janine
2
Hersh, Evan
2
Sólyom, Anikó
2
Mayr, CA
2
Salmon, Sydney
1
Craven, Mary
1
Bear, S
1
Krutzsch, Mary
1
Liddil, JD

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Publications

TOP 3
Iyengar Bhashyam S; Dorr Robert T; Remers William A
Chemical basis for the biological activity of imexon and related cyanoaziridines.
Dorr R T; Liddil J D; Sami S M; Remers W; Hersh E M; Alberts D S
Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators.
Sami S M; Dorr R T; Alberts D S; Sólyom A M; Remers W A
Analogues of amonafide and azonafide with novel ring systems.

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All Publications

2004: Iyengar Bhashyam S; Dorr Robert T; Remers William A
Chemical basis for the biological activity of imexon and related cyanoaziridines.
Journal of medicinal chemistry 2004;47(1):218-23.
2001: Dorr R T; Liddil J D; Sami S M; Remers W; Hersh E M; Alberts D S
Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators.
Anti-cancer drugs 2001;12(3):213-20.
2000: Sami S M; Dorr R T; Alberts D S; Sólyom A M; Remers W A
Analogues of amonafide and azonafide with novel ring systems.
Journal of medicinal chemistry 2000;43(16):3067-73.
1999: Mayr C A; Sami S M; Remers W A; Dorr R T
Intracellular localization of 6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquino line-1,3-diones (azonafides) is not the limiting factor for their cytotoxicity: an in vitro confocal microscopy study.
Anti-cancer drugs 1999;10(2):163-70.
1999: Iyengar B S; Dorr R T; Alberts D S; Hersh E M; Salmon S E; Remers W A
Novel antitumor 2-cyanoaziridine-1-carboxamides.
Journal of medicinal chemistry 1999;42(3):510-4.
1998: Mayr C A; Sami S M; Remers W A; Dorr R T
Identification and characterization of in vitro metabolites of 2--2'-(dimethylamino)ethyl--1,2-dihydro-3H-dibenz-de, h]isoquinoline-1,3-dione.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(2):105-9.
1997: Iyengar B S; Dorr R T; Alberts D S; Sólyom A M; Krutzsch M; Remers W A
1,4-disubstituted anthracene antitumor agents.
Journal of medicinal chemistry 1997;40(23):3734-8.
1996: Sami S M; Dorr R T; Alberts D S; Sólyom A M; Remers W A
2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships.
Journal of medicinal chemistry 1996;39(25):4978-87.
1996: Bear S; Remers W A
Computer simulation of the binding of amonafide and azonafide to DNA.
Journal of computer-aided molecular design 1996;10(2):165-75.
1996: Sami S M; Dorr R T; Sòlyom A M; Alberts D S; Iyengar B S; Remers W A
6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships.
Journal of medicinal chemistry 1996;39(8):1609-18.
1995: Sami S M; Dorr R T; Sólyom A M; Alberts D S; Remers W A
Amino-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones. Synthesis, antitumor activity, and quantitative structure--activity relationship.
Journal of medicinal chemistry 1995;38(6):983-93.
1993: Sami S M; Dorr R T; Alberts D S; Remers W A
2-substituted 1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. A new class of antitumor agent.
Journal of medicinal chemistry 1993;36(6):765-70.
1992: Dorr R T; Shipp N G; Liddil J D; Iyengar B S; Kunz K R; Remers W A
Cardiotoxicity of mitomycin A, mitomycin C, and seven N7 analogs in vitro.
Cancer chemotherapy and pharmacology 1992;31(1):1-5.
1991: Rao S N; Iyengar B S; Wunz T P; Remers W A
Molecular mechanics simulations on covalent complexes of mitomycin C and its analogues with left-handed DNA duplexes.
Journal of medicinal chemistry 1991;34(12):3380-8.
1991: Hill G C; Wunz T P; MacKenzie N E; Gooley P R; Remers W A
Computer simulation of the binding of naphthyridinomycin and cyanocycline A to DNA.
Journal of medicinal chemistry 1991;34(7):2079-88.
1991: Hill G C; Remers W A
Computer simulation of the binding of saframycin A to d (GATGCATC)2.
Journal of medicinal chemistry 1991;34(7):1990-8.
1991: Kunz K R; Iyengar B S; Dorr R T; Alberts D S; Remers W A
Structure-activity relationships for mitomycin C and mitomycin A analogues.
Journal of medicinal chemistry 1991;34(7):2281-6.
1991: Iyengar B S; Dorr R T; Remers W A
Additional nucleotide derivatives of mitosenes. Synthesis and activity against parental and multidrug resistant L1210 leukemia.
Journal of medicinal chemistry 1991;34(7):1947-51.
1991: Alberts D S; Dorr R T; Wunz T P; Remers W A; Einspahr J; Liu R; Salmon S E
In vitro cytotoxicity against fresh human tumors and P388 leukemia predicts the differential in vivo activity of a series of anthracene anticancer drugs.
Anti-cancer drugs 1991;2(1):69-77.
1990: Rao S N; Remers W A
All atom molecular mechanics simulations on covalent complexes of anthramycin and neothramycin with deoxydecanucleotides.
Journal of medicinal chemistry 1990;33(6):1701-7.
1990: Wunz T P; Craven M T; Karol M D; Hill G C; Remers W A
DNA binding by antitumor anthracene derivatives.
Journal of medicinal chemistry 1990;33(6):1549-53.
1990: Iyengar B S; Dorr R T; Shipp N G; Remers W A
Alkylation of DNA by C-10 of 2,7-diaminomitosene.
Journal of medicinal chemistry 1990;33(1):253-7.
1989: Iyengar B S; Remers W A; Catino J J
New 2-substituted indoloquinone mitomycin analogues.
Journal of medicinal chemistry 1989;32(8):1866-72.
1989: Bradner W T; Remers W A; Vyas D M
Structure-activity comparison of mitomycin C and mitomycin A analogues (review).
Anticancer research 1989;9(4):1095-9.
1989: Sami S M; Remers W A; Bradner W T
Preparation and antitumor activity of additional mitomycin A analogues.
Journal of medicinal chemistry 1989;32(3):703-8.
1988: Remers W A; Rao S N; Wunz T P; Kollman P A
Conformations of complexes between mitomycins and decanucleotides. 3. Sequence specificity, binding at C-10, and mitomycin analogues.
Journal of medicinal chemistry 1988;31(8):1612-20.
1988: Iyengar B S; Dorr R T; Remers W A; Kowal C D
Nucleotide derivatives of 2,7-diaminomitosene.
Journal of medicinal chemistry 1988;31(8):1579-85.
1988: Hill G C; Wunz T P; Remers W A
Computer simulation of the binding of quinocarcin to DNA. Prediction of mode of action and absolute configuration.
Journal of computer-aided molecular design 1988;2(2):91-106.
1987: Wunz T P; Dorr R T; Alberts D S; Tunget C L; Einspahr J; Milton S; Remers W A
New antitumor agents containing the anthracene nucleus.
Journal of medicinal chemistry 1987;30(8):1313-21.
1987: Sami S M; Iyengar B S; Remers W A; Bradner W T
Preparation and antitumor activity of new mitomycin A analogues.
Journal of medicinal chemistry 1987;30(1):168-73.
1986: Iyengar B S; Remers W A; Bradner W T
Preparation and antitumor activity of 7-substituted 1,2-aziridinomitosenes.
Journal of medicinal chemistry 1986;29(10):1864-8.
1986: Iyengar B S; Sami S M; Takahashi T; Sikorski E E; Remers W A; Bradner W T
Mitomycin C analogues with increased metal complexing ability.
Journal of medicinal chemistry 1986;29(9):1760-4.
1986: Iyengar B S; Kumar V; Wunz T P; Remers W A
Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
Journal of medicinal chemistry 1986;29(5):611-4.
1986: Delaware D L; Sharma M S; Iyengar B S; Remers W A; Pursiano T A
Aminoglycoside antibiotics. 7. Dihydrostreptomycin analogues.
The Journal of antibiotics 1986;39(2):251-8.
1986: Iyengar B S; Takahashi T; Remers W A; Bradner W T
Metal complexes of mitomycins.
Journal of medicinal chemistry 1986;29(1):144-7.
1985: Iyengar B S; Remers W A
A comparison of mechanisms proposed for the conversion of mitomycins into mitosenes.
Journal of medicinal chemistry 1985;28(7):963-7.
1985: Casner M L; Remers W A; Bradner W T
Synthesis and biological activity of 6-substituted mitosene analogues of the mitomycins.
Journal of medicinal chemistry 1985;28(7):921-6.
1984: Sami S M; Iyengar B S; Tarnow S E; Remers W A; Bradner W T; Schurig J E
Mitomycin C analogues with aryl substituents on the 7-amino group.
Journal of medicinal chemistry 1984;27(5):701-8.
1983: Iyengar B S; Sami S M; Tarnow S E; Remers W A; Bradner W T; Schurig J E
Mitomycin C analogues with secondary amines at position 7.
Journal of medicinal chemistry 1983;26(10):1453-7.
1983: Iyengar B S; Sami S M; Remers W A; Bradner W T; Schurig J E
Mitomycin C and porfiromycin analogues with substituted ethylamines at position 7.
Journal of medicinal chemistry 1983;26(1):16-20.
1981: Hodges J C; Remers W A; Bradner W T
Synthesis and antineoplastic activity of mitosene analogues of the mitomycins.
Journal of medicinal chemistry 1981;24(10):1184-91.
1981: Iyengar B S; Lin H J; Cheng L; Remers W A; Bradner W T
Development of new mitomycin C and porfiromycin analogues.
Journal of medicinal chemistry 1981;24(8):975-81.
1980: Kumar V; Remers W A; Bradner W T
Preparation and antitumor activity of olivomycin A analogues.
Journal of medicinal chemistry 1980;23(4):376-9.
1980: Kumar V; Jones G S; Blacksberg I; Remers W A; Misiek M; Pursiano T A
Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B.
Journal of medicinal chemistry 1980;23(1):42-9.

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