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Shuyu Ren

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Shuyu Ren; Cuiyan Xin; Josef Pfeilschifter; Andrea Huwiler
A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation.
Shuyu Ren; Andrea Babelova; Kristin Moreth; Cuiyan Xin; Wolfgang Eberhardt; Anke Doller; Hermann Pavenstädt; Liliana Schaefer; Josef Pfeilschifter; Andrea Huwiler
Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.
Lotte P Hofmann; Shuyu Ren; Stephanie Schwalm; Josef Pfeilschifter; Andrea Huwiler
Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner.

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All Publications

2010: Shuyu Ren; Cuiyan Xin; Josef Pfeilschifter; Andrea Huwiler
A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;26(1):97-104.
2009: Shuyu Ren; Andrea Babelova; Kristin Moreth; Cuiyan Xin; Wolfgang Eberhardt; Anke Doller; Hermann Pavenstädt; Liliana Schaefer; Josef Pfeilschifter; Andrea Huwiler
Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.
Kidney international 2009;76(8):857-67.
2008: Lotte P Hofmann; Shuyu Ren; Stephanie Schwalm; Josef Pfeilschifter; Andrea Huwiler
Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner.
Biological chemistry 2008;389(11):1399-407.
2007: Cuiyan Xin; Shuyu Ren; Wolfgang Eberhardt; Josef Pfeilschifter; Andrea Huwiler
Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.
Journal of lipid research 2007;48(9):1985-96.
2007: Cuiyan Xin; Shuyu Ren; Wolfgang Eberhardt; Josef Pfeilschifter; Andrea Huwiler
FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.
British journal of pharmacology 2007;150(7):943-50.
2006: Andrea Huwiler; Frauke Döll; Shuyu Ren; Sabine Klawitter; Anna Greening; Isolde Römer; Svetlana Bubnova; Luise Reinsberg; Josef Pfeilschifter
Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism.
Biochimica et biophysica acta 2006;1761(3):367-76.
2006: Cuiyan Xin; Shuyu Ren; Wolfgang Eberhardt; Josef Pfeilschifter; Andrea Huwiler
The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.
British journal of pharmacology 2006;147(2):164-74.
2005: Shuyu Ren; Cuiyan Xin; Karl-Friedrich Beck; Moin A Saleem; Peter Mathieson; Hermann Pavenstädt; Josef Pfeilschifter; Andrea Huwiler
PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism.
Biochemical and biophysical research communications 2005;338(4):1818-24.
2004: Cuiyan Xin; Shuyu Ren; Josef Pfeilschifter; Andrea Huwiler
Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells.
British journal of pharmacology 2004;143(5):581-9.
2004: Cuiyan Xin; Shuyu Ren; Burkhard Kleuser; Soheyla Shabahang; Wolfgang Eberhardt; Heinfried Radeke; Monika Schäfer-Korting; Josef Pfeilschifter; Andrea Huwiler
Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses.
The Journal of biological chemistry 2004;279(34):35255-62.
2003: Andrea Huwiler; Shuyu Ren; Harry Holthöfer; Hermann Pavenstädt; Josef Pfeilschifter
Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes.
Biochemical and biophysical research communications 2003;305(1):136-42.
2003: Waltraud Rölz; Cuiyan Xin; Shuyu Ren; Josef Pfeilschifter; Andrea Huwiler
Interleukin-1beta inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide.
British journal of pharmacology 2003;138(3):461-8.
2002: Andrea Huwiler; Waltraud Rölz; Simone Dorsch; Shuyu Ren; Josef Pfeilschifter
Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells.
British journal of pharmacology 2002;136(4):520-9.
2002: Waltraud Rölz; Cuiyan Xin; Shuyu Ren; Josef Pfeilschifter; Andrea Huwiler
Interleukin-1 inhibits angiotensin II-stimulated protein kinase B pathway in renal mesangial cells via the inducible nitric oxide synthase.
European journal of pharmacology 2002;442(3):195-203.