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Michael Resnick

Research Profile

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Saccharomyces cerevisiae

Physiology

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Fungal Chromosomes

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TOP 3
Jennifer H Madenspacher; Kenneth C Malcolm; Daniel Menendez; B Alex Merrick; Jerry A Nick; Michael A Resnick; Maria Shatz; Jim J Aloor; Kathleen M Azzam; Pierre Bushel; Darlene Dixon; David W Draper; Kymberly M Gowdy; John J Guardiola; Leping Li; Julie Lowe; Jun Lu; Michael B Fessler
p53 integrates host defense and cell fate during bacterial pneumonia.
Mattia Lion; Daniel Menendez; Michael A Resnick; Toma Tebaldi; Alessandra Bisio; Yari Ciribilli; Veronica De Sanctis; Alberto Inga
Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics.
James W Westmoreland; Michael A Resnick
Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nuclease.

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All Publications

2013: Jennifer H Madenspacher; Kenneth C Malcolm; Daniel Menendez; B Alex Merrick; Jerry A Nick; Michael A Resnick; Maria Shatz; Jim J Aloor; Kathleen M Azzam; Pierre Bushel; Darlene Dixon; David W Draper; Kymberly M Gowdy; John J Guardiola; Leping Li; Julie Lowe; Jun Lu; Michael B Fessler
p53 integrates host defense and cell fate during bacterial pneumonia.
The Journal of experimental medicine 2013;210(5):891-904.
2013: Mattia Lion; Daniel Menendez; Michael A Resnick; Toma Tebaldi; Alessandra Bisio; Yari Ciribilli; Veronica De Sanctis; Alberto Inga
Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics.
Cell cycle (Georgetown, Tex.) 2013;12(8):1211-24.
2013: James W Westmoreland; Michael A Resnick
Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nuclease.
PLoS genetics 2013;9(3):e1003420.
2013: Jennifer Summers McKinney; Thuy N Nguyen; Michael A Resnick; Brian A Sanderson; Sunaina Sethi; Jennifer Demars Tripp; James W Westmoreland; L Kevin Lewis
A multistep genomic screen identifies new genes required for repair of DNA double-strand breaks in Saccharomyces cerevisiae.
BMC genomics 2013;14(1):251.
2013: Daniel Menendez; Maria Shatz; Michael A Resnick
Interactions between the tumor suppressor p53 and immune responses.
Current opinion in oncology 2013;25(1):85-92.
2012: Daniel Menendez; Michael A Resnick; Tali E Haran
Transactivation by low and high levels of human p53 reveals new physical rules of engagement and novel super-transactivation sequences.
Cell cycle (Georgetown, Tex.) 2012;11(23):4287-8.
2012: Shay Covo; Dmitry A Gordenin; Wenjian Ma; James W Westmoreland; Michael A Resnick
Understanding the origins of UV-induced recombination through manipulation of sister chromatid cohesion.
Cell cycle (Georgetown, Tex.) 2012;11(21):3937-44.
2012: Jennifer J Jordan; Daniel Menendez; Michael A Resnick; Karin Rosenthal; Jenia Sharav; Itai Beno; Tali E Haran
Low-level p53 expression changes transactivation rules and reveals superactivating sequences.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14387-92.
2012: Maria Shatz; Daniel Menendez; Michael A Resnick
The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells.
Cancer research 2012;72(16):3948-57.
2012: Steven A Roberts; Ruchir Shah; Joan Sterling; Cole Thompson; Shawn Harris; Leszek J Klimczak; Gregory V Kryukov; Ewa Malc; Deepak Mav; Piotr A Mieczkowski; Michael A Resnick; Dmitry A Gordenin
Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.
Molecular cell 2012;46(4):424-35.
2012: Wenjian Ma; Daniel Menendez; Christopher J Halweg; Michael A Resnick
Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):6590-5.
2012: Shay Covo; Dmitry A Gordenin; Amit K Reddy; James W Westmoreland; Michael A Resnick
RAD53 is limiting in double-strand break repair and in protection against toxicity associated with ribonucleotide reductase inhibition.
DNA repair 2012;11(3):317-23.
2012: Kin Chan; Michael A Resnick; Steven A Roberts; Joan F Sterling; Ashok S Bhagwat; Dmitry A Gordenin
Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent.
PLoS genetics 2012;8(12):e1003149.
2011: Wenjian Ma; James W Westmoreland; Dmitry A Gordenin; Michael A Resnick
Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease.
PLoS genetics 2011;7(4):e1002059.
2011: Lauranell H Burch; Yong Yang; Joan F Sterling; Steven A Roberts; Frank G Chao; Hong Xu; Leilei Zhang; Jesse Walsh; Michael A Resnick; Piotr A Mieczkowski; Dmitry A Gordenin
Damage-induced localized hypermutability.
Cell cycle (Georgetown, Tex.) 2011;10(7):1073-85.
2011: Daniel Menendez; Maria Shatz; Kathleen Azzam; Stavros Garantziotis; Michael B Fessler; Michael A Resnick
The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.
PLoS genetics 2011;7(3):e1001360.
2011: Paola Monti; Chiara Perfumo; Alessandra Bisio; Yari Ciribilli; Paola Menichini; Debora Russo; David M Umbach; Michael A Resnick; Alberto Inga; Gilberto Fronza
Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.
Molecular cancer research : MCR 2011;9(3):271-9.
2011: Wataru Nakai; James W Westmoreland; Elaine Yeh; Kerry Bloom; Michael A Resnick
Chromosome integrity at a double-strand break requires exonuclease 1 and MRX.
DNA repair 2011;10(1):102-10.
2011: Virginia Andreotti; Alessandra Bisio; Yari Ciribilli; Gilberto Fronza; Jennifer Jordan; Mattia Lion; Paola Menichini; Paola Monti; Michael A Resnick; Alberto Inga
p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system.
PloS one 2011;6(6):e20643.
2011: Wenjian Ma; Anna Malkova; Wataru Nakai; James W Westmoreland; Michael A Resnick
Characterizing resection at random and unique chromosome double-strand breaks and telomere ends.
Methods in molecular biology (Clifton, N.J.) 2011;745():15-31.
2010: Andres A Larrea; Scott A Lujan; Stephanie A Nick McElhinny; Piotr A Mieczkowski; Michael A Resnick; Dmitry A Gordenin; Thomas A Kunkel
Genome-wide model for the normal eukaryotic DNA replication fork.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17674-9.
2010: Yong Yang; Dmitry A Gordenin; Michael A Resnick
A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast.
DNA repair 2010;9(8):914-21.
2010: Daniel Menendez; Alberto Inga; Michael A Resnick
Potentiating the p53 network.
Discovery medicine 2010;10(50):94-100.
2010: Shay Covo; James W Westmoreland; Dmitry A Gordenin; Michael A Resnick
Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes.
PLoS genetics 2010;6(7):e1001006.
2010: James W Westmoreland; Jennifer A Summers; Cory L Holland; Michael A Resnick; L Kevin Lewis
Blunt-ended DNA double-strand breaks induced by endonucleases PvuII and EcoRV are poor substrates for repair in Saccharomyces cerevisiae.
DNA repair 2010;9(6):617-26.
2010: Jennifer J Jordan; Alberto Inga; Kathleen Dorsey; Sharon Edmiston; Lisa A Carey; Lin Wu; Michael A Resnick
Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.
Molecular cancer research : MCR 2010;8(5):701-16.
2010: Daniel Menendez; Alberto Inga; Michael A Resnick
Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(4):1500-5.
2010: Yari Ciribilli; Virginia Andreotti; Daniel Menendez; Jan-Stephan Langen; Gilbert Schoenfelder; Michael A Resnick; Alberto Inga
The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound.
PloS one 2010;5(4):e10236.
2009: Daniel Menendez; Alberto Inga; Michael A Resnick
The expanding universe of p53 targets.
Nature reviews. Cancer 2009;9(10):724-37.
2009: Jim Westmoreland; Wenjian Ma; Yan Yan; Kelly Van Hulle; Anna Malkova; Michael A Resnick
RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.
PLoS genetics 2009;5(9):e1000656.
2009: Maher A Noureddine; Daniel Menendez; Michelle R Campbell; Omari J Bandele; Monica M Horvath; Xuting Wang; Gary S Pittman; Brian N Chorley; Michael A Resnick; Douglas A Bell
Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts.
PLoS genetics 2009;5(5):e1000462.
2009: Wenjian Ma; Vijayalakshmi Panduri; Joan F Sterling; Bennett Van Houten; Dmitry A Gordenin; Michael A Resnick
The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1.
Molecular and cellular biology 2009;29(5):1212-21.
2009: Brian M Wasko; Cory L Holland; Michael A Resnick; L Kevin Lewis
Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae.
DNA repair 2009;8(2):162-9.
2008: Carrie M Stith; Joan Sterling; Michael A Resnick; Dmitry A Gordenin; Peter M J Burgers
Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesis.
The Journal of biological chemistry 2008;283(49):34129-40.
2008: Yong Yang; Joan Sterling; Francesca Storici; Michael A Resnick; Dmitry A Gordenin
Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.
PLoS genetics 2008;4(11):e1000264.
2008: Juan Lucas Argueso; James Westmoreland; Piotr A Mieczkowski; Malgorzata Gawel; Thomas D Petes; Michael A Resnick
Double-strand breaks associated with repetitive DNA can reshape the genome.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11845-50.
2008: Jennifer J Jordan; Daniel Menendez; Alberto Inga; Maher Noureddine; Maher Nourredine; Douglas A Bell; Douglas Bell; Michael A Resnick
Noncanonical DNA motifs as transactivation targets by wild type and mutant p53.
PLoS genetics 2008;4(6):e1000104.
2008: Wenjian Ma; Michael A Resnick; Dmitry A Gordenin
Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis.
Nucleic acids research 2008;36(6):1836-46.
2008: anil jegga; Alberto Inga; Daniel Menendez; Bruce Aronow; Michael A Resnick
Functional evolution of the p53 regulatory network through its target response elements.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(3):944-9.
2007: Monica M Horvath; Xuting Wang; Michael A Resnick; Douglas A Bell
Divergent evolution of human p53 binding sites: cell cycle versus apoptosis.
PLoS genetics 2007;3(7):e127.
2007: Paola Monti; Yari Ciribilli; Jennifer Jordan; Paola Menichini; David M Umbach; Michael A Resnick; Lucio Luzzatto; Alberto Inga; Gilberto Fronza
Transcriptional functionality of germ line p53 mutants influences cancer phenotype.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(13):3789-95.
2007: Francesca Storici; Katarzyna Bebenek; Thomas A Kunkel; Dmitry A Gordenin; Michael A Resnick
RNA-templated DNA repair.
Nature 2007;447(7142):338-41.
2007: Daniel Menendez; Alberto Inga; J J Jordan; Michael A Resnick
Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson.
Oncogene 2007;26(15):2191-201.
2007: Daniel Menendez; Alberto Inga; Joyce R Snipe; Oliver Krysiak; Gilbert Schönfelder; Michael A Resnick
A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1.
Molecular and cellular biology 2007;27(7):2590-600.
2006: Francesca Storici; Joyce R Snipe; Godwin K Chan; Dmitry A Gordenin; Michael A Resnick
Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing.
Molecular and cellular biology 2006;26(20):7645-57.
2006: Daniel Menendez; Alberto Inga; Michael A Resnick
The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes.
Molecular and cellular biology 2006;26(6):2297-308.
2006: Daniel Menendez; Oliver Krysiak; Alberto Inga; Bianca Krysiak; Michael A Resnick; Gilbert Schönfelder
A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1406-11.
2006: Francesca Storici; Michael A Resnick
The delitto perfetto approach to in vivo site-directed mutagenesis and chromosome rearrangements with synthetic oligonucleotides in yeast.
Methods in enzymology 2006;409():329-45.
2005: L Kevin Lewis; Kirill S Lobachev; James W Westmoreland; G Karthikeyan; Kelly M Williamson; Jennifer J Jordan; Michael A Resnick
Use of a restriction endonuclease cytotoxicity assay to identify inducible GAL1 promoter variants with reduced basal activity.
Gene 2005;363():183-92.
2005: Michael A Resnick; Daniel J Tomso; Alberto Inga; Daniel Menendez; Douglas Bell
Functional diversity in the gene network controlled by the master regulator p53 in humans.
Cell cycle (Georgetown, Tex.) 2005;4(8):1026-9.
2005: Alberto Inga; Stella Marie Reamon-Buettner; Jürgen Borlak; Michael A Resnick
Functional dissection of sequence-specific NKX2-5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system.
Human molecular genetics 2005;14(14):1965-75.
2005: Daniel J Tomso; Alberto Inga; Daniel Menendez; Gary S Pittman; Michelle R Campbell; Francesca Storici; Douglas A Bell; Michael A Resnick
Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6431-6.
2005: Michael A Resnick
Reduced replication: a call to ARMS.
Cell 2005;120(5):569-70.
2005: Gopalakrishnan Karthikeyan; Michael A Resnick
Impact of mitochondria on nuclear genome stability.
DNA repair 2005;4(2):141-8.
2005: Ling Chen; Kelly M Trujillo; Stephen Van Komen; Dong Hyun Roh; Lumir Krejci; L Kevin Lewis; Michael A Resnick; Patrick Sung; Alan E Tomkinson
Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast.
The Journal of biological chemistry 2005;280(4):2620-7.
2005: L Kevin Lewis; G Karthikeyan; Jared Cassiano; Michael A Resnick
Reduction of nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair.
Nucleic acids research 2005;33(15):4928-39.
2005: Yong Hwan Jin; Parie Garg; Carrie M Stith; Hanan Al-Refai; Joan F Sterling; Laura J W Murray; Thomas A Kunkel; Michael A Resnick; Peter M J Burgers; Dmitry A Gordenin
The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains.
Molecular and cellular biology 2005;25(1):461-71.
2004: Kirill S Lobachev; Eric Vitriol; Jennifer Stemple; Michael A Resnick; Kerry Bloom
Chromosome fragmentation after induction of a double-strand break is an active process prevented by the RMX repair complex.
Current biology : CB 2004;14(23):2107-12.
2004: L Kevin Lewis; Francesca Storici; Stephen Van Komen; Shanna Calero; Patrick Sung; Michael A Resnick
Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.
Genetics 2004;166(4):1701-13.
2004: Tammy J Westmoreland; Jeffrey R Marks; John Olson; Eric M Thompson; Michael A Resnick; Craig B Bennett
Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae.
Eukaryotic cell 2004;3(2):430-46.
2003: Gopalakrishnan Karthikeyan; Janine H Santos; Maria A Graziewicz; William C Copeland; Grazia Isaya; Bennett Van Houten; Michael A Resnick
Reduction in frataxin causes progressive accumulation of mitochondrial damage.
Human molecular genetics 2003;12(24):3331-42.
2003: Francesca Storici; Christopher L Durham; Dmitry A Gordenin; Michael A Resnick
Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14994-9.
2003: Michael A Resnick; Alberto Inga
Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9934-9.
2003: Yong Hwan Jin; Alan B Clark; Robbert J C Slebos; Hanan Al-Refai; Jack A Taylor; Thomas A Kunkel; Michael A Resnick; Dmitry A Gordenin
Cadmium is a mutagen that acts by inhibiting mismatch repair.
Nature genetics 2003;34(3):326-9.
2003: Yong Hwan Jin; Rao Ayyagari; Michael A Resnick; Dmitry A Gordenin; Peter M J Burgers
Okazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nick.
The Journal of biological chemistry 2003;278(3):1626-33.
2003: Francesca Storici; Michael A Resnick
Delitto perfetto targeted mutagenesis in yeast with oligonucleotides.
Genetic engineering 2003;25():189-207.
2002: Alberto Inga; Francesca Storici; Thomas A Darden; Michael A Resnick
Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.
Molecular and cellular biology 2002;22(24):8612-25.
2002: Francesca Storici; Ghislaine Henneke; Elena Ferrari; Dmitry A Gordenin; Ulrich Hübscher; Michael A Resnick
The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.
The EMBO journal 2002;21(21):5930-42.
2002: Kikuo Shimizu; Keiji Hashimoto; Jakob Kirchner; Wataru Nakai; Hiroko Nishikawa; Michael A Resnick; Akio Sugino
Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 2002;277(40):37422-9.
2002: Alberto Inga; Dorit Nahari; Susana Velasco-Miguel; Errol C Friedberg; Michael A Resnick
A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions.
Oncogene 2002;21(37):5704-15.
2002: Gopalakrishnan Karthikeyan; L Kevin Lewis; Michael A Resnick
The mitochondrial protein frataxin prevents nuclear damage.
Human molecular genetics 2002;11(11):1351-62.
2002: Paola Monti; Paola Campomenosi; Yari Ciribilli; Raffaella Iannone; Alberto Inga; Angelo Abbondandolo; Michael A Resnick; Gilberto Fronza
Tumour p53 mutations exhibit promoter selective dominance over wild type p53.
Oncogene 2002;21(11):1641-8.
2002: Kirill S Lobachev; Dmitry A Gordenin; Michael A Resnick
The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements.
Cell 2002;108(2):183-93.
2002: L Kevin Lewis; Gopalakrishnan Karthikeyan; James W Westmoreland; Michael A Resnick
Differential suppression of DNA repair deficiencies of Yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase).
Genetics 2002;160(1):49-62.
2001: Craig B Bennett; L Kevin Lewis; Gopalakrishnan Karthikeyan; Kirill S Lobachev; Yong Hwan Jin; J F Sterling; Joyce R Snipe; Michael A Resnick
Genes required for ionizing radiation resistance in yeast.
Nature genetics 2001;29(4):426-34.
2001: Francesca Storici; L Kevin Lewis; Michael A Resnick
In vivo site-directed mutagenesis using oligonucleotides.
Nature biotechnology 2001;19(8):773-6.
2001: Craig B Bennett; Joyce R Snipe; James W Westmoreland; Michael A Resnick
SIR functions are required for the toleration of an unrepaired double-strand break in a dispensable yeast chromosome.
Molecular and cellular biology 2001;21(16):5359-73.
2001: Paola Campomenosi; Paola Monti; Anna Aprile; Angelo Abbondandolo; Thierry Frebourg; Barry Gold; T Crook; Alberto Inga; Michael A Resnick; Richard D Iggo; Gilberto Fronza
p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements.
Oncogene 2001;20(27):3573-9.
2001: Alberto Inga; Michael A Resnick
Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants.
Oncogene 2001;20(26):3409-19.
2001: Jakob Kirchner; V Ivanova; A Samson; V N Noskov; J N Volff; Michael A Resnick; R B Walter
Transformation-associated recombination (TAR) cloning of tumor-inducing Xmrk2 gene from Xiphophorus maculatus.
Marine biotechnology (New York, N.Y.) 2001;3(Supplement 1):S168-76.
2001: Yong Hwan Jin; R Obert; Peter M J Burgers; Thomas A Kunkel; Michael A Resnick; Dmitry A Gordenin
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5122-7.
2001: Alberto Inga; Paola Monti; Gilberto Fronza; Thomas A Darden; Michael A Resnick
p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay.
Oncogene 2001;20(4):501-13.
2001: J E Stenger; Kirill S Lobachev; Dmitry A Gordenin; T A Darden; Jerzy Jurka; Michael A Resnick
Biased distribution of inverted and direct Alus in the human genome: implications for insertion, exclusion, and genome stability.
Genome research 2001;11(1):12-27.
2000: Michael C Humble; Natalay Kouprina; Vladimir N Noskov; Joan Graves; E Garner; Raymond W Tennant; Michael A Resnick; Vladimir Larionov; Ronald E Cannon
Radial transformation-associated recombination cloning from the mouse genome: isolation of Tg.AC transgene with flanking DNAs.
Genomics 2000;70(3):292-9.
2000: Jakob Kirchner; Hiep T Tran; Michael A Resnick
A DNA polymerase epsilon mutant that specifically causes +1 frameshift mutations within homonucleotide runs in yeast.
Genetics 2000;155(4):1623-32.
2000: Kirill S Lobachev; J E Stenger; O G Kozyreva; Jerzy Jurka; Dmitry A Gordenin; Michael A Resnick
Inverted Alu repeats unstable in yeast are excluded from the human genome.
The EMBO journal 2000;19(14):3822-30.
2000: L Kevin Lewis; Michael A Resnick
Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae.
Mutation research 2000;451(1-2):71-89.
1999: A L Greene; Joyce R Snipe; Dmitry A Gordenin; Michael A Resnick
Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability.
Human molecular genetics 1999;8(12):2263-73.
1999: L Kevin Lewis; James W Westmoreland; Michael A Resnick
Repair of endonuclease-induced double-strand breaks in Saccharomyces cerevisiae: essential role for genes associated with nonhomologous end-joining.
Genetics 1999;152(4):1513-29.
1999: Ronald K Gary; MS Park; J P Nolan; HL Cornelius; O G Kozyreva; Hiep T Tran; Kirill S Lobachev; Michael A Resnick; Dmitry A Gordenin
A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.
Molecular and cellular biology 1999;19(8):5373-82.
1999: Hiep T Tran; N P Degtyareva; Dmitry A Gordenin; Michael A Resnick
Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast.
Genetics 1999;152(1):47-59.
1999: Karin Drotschmann; Alan B Clark; Hiep T Tran; Michael A Resnick; Dmitry A Gordenin; Thomas A Kunkel
Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2970-5.
1999: Natalay Kouprina; N Nikolaishvili; Joan Graves; Maxim Koriabine; Michael A Resnick; Vladimir Larionov
Integrity of human YACs during propagation in recombination-deficient yeast strains.
Genomics 1999;56(3):262-73.
1999: Edward L Perkins; J F Sterling; V I Hashem; Michael A Resnick
Yeast and human genes that affect the Escherichia coli SOS response.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2204-9.
1999: Hiep T Tran; Dmitry A Gordenin; Michael A Resnick
The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae.
Molecular and cellular biology 1999;19(3):2000-7.
1999: Alan B Clark; M E Cook; Hiep T Tran; Dmitry A Gordenin; Michael A Resnick; Thomas A Kunkel
Functional analysis of human MutSalpha and MutSbeta complexes in yeast.
Nucleic acids research 1999;27(3):736-42.
1998: Robbert J C Slebos; Michael A Resnick; Jack A Taylor
Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement.
Cancer research 1998;58(23):5333-6.
1998: Dmitry A Gordenin; Michael A Resnick
Yeast ARMs (DNA at-risk motifs) can reveal sources of genome instability.
Mutation research 1998;400(1-2):45-58.
1998: RJ Kokoska; Lela Stefanovic; Hiep T Tran; Michael A Resnick; Dmitry A Gordenin; Thomas D Petes
Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t).
Molecular and cellular biology 1998;18(5):2779-88.
1998: Natalay Kouprina; Lois A Annab; Joan Graves; Cynthia A Afshari; J Carl Barrett; Michael A Resnick; Vladimir Larionov
Functional copies of a human gene can be directly isolated by transformation-associated recombination cloning with a small 3' end target sequence.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4469-74.
1998: Kirill S Lobachev; B M Shor; Hiep T Tran; W Taylor; J D Keen; Michael A Resnick; Dmitry A Gordenin
Factors affecting inverted repeat stimulation of recombination and deletion in Saccharomyces cerevisiae.
Genetics 1998;148(4):1507-24.
1998: L Kevin Lewis; Jakob Kirchner; Michael A Resnick
Requirement for end-joining and checkpoint functions, but not RAD52-mediated recombination, after EcoRI endonuclease cleavage of Saccharomyces cerevisiae DNA.
Molecular and cellular biology 1998;18(4):1891-902.
1998: Michael Cancilla; KM Tainton; Alyssa Barry; Vladimir Larionov; Natalay Kouprina; Michael A Resnick; D D Sart; K H Andy Choo
Direct cloning of human 10q25 neocentromere DNA using transformation-associated recombination (TAR) in yeast.
Genomics 1998;47(3):399-404.
1998: Michael Cancilla; Joan Graves; LE Matesic; Roger H Reeves; KM Tainton; K H Andy Choo; Michael A Resnick; Vladimir Larionov; Natalay Kouprina
Rapid cloning of mouse DNA as yeast artificial chromosomes by transformation-associated recombination (TAR).
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(2):157-9.
1997: Natalay Kouprina; Joan Graves; Michael Cancilla; Michael A Resnick; Vladimir Larionov
Specific isolation of human rDNA genes by TAR cloning.
Gene 1997;197(1-2):269-76.
1997: Vladimir Larionov; Natalay Kouprina; Greg Solomon; J Carl Barrett; Michael A Resnick
Direct isolation of human BRCA2 gene by transformation-associated recombination in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7384-7.
1997: Dmitry A Gordenin; Thomas A Kunkel; Michael A Resnick
Repeat expansion--all in a flap?
Nature genetics 1997;16(2):116-8.
1997: Craig B Bennett; Joyce R Snipe; Michael A Resnick
A persistent double-strand break destabilizes human DNA in yeast and can lead to G2 arrest and lethality.
Cancer research 1997;57(10):1970-80.
1997: Hiep T Tran; J D Keen; M Kricker; Michael A Resnick; Dmitry A Gordenin
Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.
Molecular and cellular biology 1997;17(5):2859-65.
1997: Hiep T Tran; N Degtyareva; Dmitry A Gordenin; Michael A Resnick
Altered replication and inverted repeats induce mismatch repair-independent recombination between highly diverged DNAs in yeast.
Molecular and cellular biology 1997;17(2):1027-36.
1997: Thomas A Kunkel; Michael A Resnick; Dmitry A Gordenin
Mutator specificity and disease: looking over the FENce.
Cell 1997;88(2):155-8.
1997: James W Westmoreland; G Porter; M Radman; Michael A Resnick
Highly mismatched molecules resembling recombination intermediates efficiently transform mismatch repair proficient Escherichia coli.
Genetics 1997;145(1):29-38.
1996: Vladimir Larionov; Natalay Kouprina; Joan Graves; Michael A Resnick
Highly selective isolation of human DNAs from rodent-human hybrid cells as circular yeast artificial chromosomes by transformation-associated recombination cloning.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13925-30.
1996: Hiep T Tran; Dmitry A Gordenin; Michael A Resnick
The prevention of repeat-associated deletions in Saccharomyces cerevisiae by mismatch repair depends on size and origin of deletions.
Genetics 1996;143(4):1579-87.
1996: C B Bennett; T J Westmoreland; Joyce R Snipe; Michael A Resnick
A double-strand break within a yeast artificial chromosome (YAC) containing human DNA can result in YAC loss, deletion or cell lethality.
Molecular and cellular biology 1996;16(8):4414-25.
1996: G Porter; J Westmoreland; Stefan Priebe; Michael A Resnick
Homologous and homeologous intermolecular gene conversion are not differentially affected by mutations in the DNA damage or the mismatch repair genes RAD1, RAD50, RAD51, RAD52, RAD54, PMS1 and MSH2.
Genetics 1996;143(2):755-67.
1996: Vladimir Larionov; Natalay Kouprina; Joan Graves; X N Chen; julie R korenberg; Michael A Resnick
Specific cloning of human DNA as yeast artificial chromosomes by transformation-associated recombination.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):491-6.
1995: Hiep T Tran; N P Degtyareva; N N Koloteva; Akio Sugino; H Masumoto; Dmitry A Gordenin; Michael A Resnick
Replication slippage between distant short repeats in Saccharomyces cerevisiae depends on the direction of replication and the RAD50 and RAD52 genes.
Molecular and cellular biology 1995;15(10):5607-17.
1994: Vladimir Larionov; Joan Graves; Natalay Kouprina; Michael A Resnick
The role of recombination and RAD52 in mutation of chromosomal DNA transformed into yeast.
Nucleic acids research 1994;22(20):4234-41.
1994: Vladimir Larionov; Natalay Kouprina; N Nikolaishvili; Michael A Resnick
Recombination during transformation as a source of chimeric mammalian artificial chromosomes in yeast (YACs).
Nucleic acids research 1994;22(20):4154-62.
1994: S D Priebe; J Westmoreland; T Nilsson-Tillgren; Michael A Resnick
Induction of recombination between homologous and diverged DNAs by double-strand gaps and breaks and role of mismatch repair.
Molecular and cellular biology 1994;14(7):4802-14.
1994: Vladimir Larionov; Natalay Kouprina; M Eldarov; Edward L Perkins; G Porter; Michael A Resnick
Transformation-associated recombination between diverged and homologous DNA repeats is induced by strand breaks.
Yeast (Chichester, England) 1994;10(1):93-104.
1993: Dmitry A Gordenin; Kirill S Lobachev; N P Degtyareva; Anna L Malkova; Edward L Perkins; Michael A Resnick
Inverted DNA repeats: a source of eukaryotic genomic instability.
Molecular and cellular biology 1993;13(9):5315-22.
1993: C B Bennett; A L Lewis; K K Baldwin; Michael A Resnick
Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5613-7.
1992: T Y Chow; Edward L Perkins; Michael A Resnick
Yeast RNC1 encodes a chimeric protein, RhoNUC, with a human rho motif and deoxyribonuclease activity.
Nucleic acids research 1992;20(19):5215-21.
1992: Michael A Resnick; Z Zgaga; P Hieter; J Westmoreland; S Fogel; T Nilsson-Tillgren
Recombinant repair of diverged DNAs: a study of homoeologous chromosomes and mammalian YACs in yeast.
Molecular & general genetics : MGG 1992;234(1):65-73.
1992: Dmitry A Gordenin; Anna L Malkova; A Peterzen; V N Kulikov; Youri I Pavlov; Edward L Perkins; Michael A Resnick
Transposon Tn5 excision in yeast: influence of DNA polymerases alpha, delta, and epsilon and repair genes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3785-9.
1990: S G Whittaker; S F Moser; D H Maloney; Walter W Piegorsch; Michael A Resnick; S Fogel
The detection of mitotic and meiotic chromosome gain in the yeast Saccharomyces cerevisiae: effects of methyl benzimidazol-2-yl carbamate, methyl methanesulfonate, ethyl methanesulfonate, dimethyl sulfoxide, propionitrile and cyclophosphamide monohydrate.
Mutation research 1990;242(3):231-58.
1990: Michael A Resnick; J Westmoreland; Kerry Bloom
Heterogeneity and maintenance of centromere plasmid copy number in Saccharomyces cerevisiae.
Chromosoma 1990;99(4):281-8.
1990: S G Whittaker; F K Zimmermann; B Dicus; Walter W Piegorsch; Michael A Resnick; S Fogel
Detection of induced mitotic chromosome loss in Saccharomyces cerevisiae--an interlaboratory assessment of 12 chemicals.
Mutation research 1990;241(3):225-42.
1990: Michael A Resnick; T Nilsson-Tillgren
DNA homology and chromosome stability: a sensitive yeast genetic system for identifying double-stranded DNA damage.
Progress in clinical and biological research 1990;340B():363-9.
1989: S G Whittaker; F K Zimmermann; B Dicus; Walter W Piegorsch; S Fogel; Michael A Resnick
Detection of induced mitotic chromosome loss in Saccharomyces cerevisiae--an interlaboratory study.
Mutation research 1989;224(1):31-78.
1989: Walter W Piegorsch; F K Zimmermann; S Fogel; S G Whittaker; Michael A Resnick
Quantitative approaches for assessing chromosome loss in Saccharomyces cerevisiae: general methods for analyzing downturns in dose response.
Mutation research 1989;224(1):11-29.
1989: Michael A Resnick; M Skaanild; T Nilsson-Tillgren
Lack of DNA homology in a pair of divergent chromosomes greatly sensitizes them to loss by DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2276-80.
1989: F K Zimmerman; S G Whittaker; S Fogel; Michael A Resnick
Detection of mitotic and meiotic chromosome malsegregation.
Progress in clinical and biological research 1989;318():367-76.
1989: Michael A Resnick; J Westmoreland; Kerry Bloom; T Nilsson-Tillgren
Chromosome interactions and number of centromeres per cell are important to chromosome stability in yeast.
Progress in clinical and biological research 1989;318():317-24.
1988: S G Whittaker; B M Rockmill; A E Blechl; D H Maloney; Michael A Resnick; S Fogel
The detection of mitotic and meiotic aneuploidy in yeast using a gene dosage selection system.
Molecular & general genetics : MGG 1988;215(1):10-8.
1988: Akio Sugino; John L. Nitiss; Michael A Resnick
ATP-independent DNA strand transfer catalyzed by protein(s) from meiotic cells of the yeast Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3683-7.
1988: T Y Chow; Michael A Resnick
An endo-exonuclease activity of yeast that requires a functional RAD52 gene.
Molecular & general genetics : MGG 1988;211(1):41-8.
1987: T Y Chow; Michael A Resnick
Purification and characterization of an endo-exonuclease from Saccharomyces cerevisiae that is influenced by the RAD52 gene.
The Journal of biological chemistry 1987;262(36):17659-67.
1987: Michael A Resnick; J Westmoreland; E Amaya; Kerry Bloom
UV-induced damage and repair in centromere DNA of yeast.
Molecular & general genetics : MGG 1987;210(1):16-22.
1986: Michael A Resnick; John L. Nitiss; C Edwards; R E Malone
Meiosis can induce recombination in rad52 mutants of Saccharomyces cerevisiae.
Genetics 1986;113(3):531-50.
1984: Michael A Resnick; Akio Sugino; John L. Nitiss; T Chow
DNA polymerases, deoxyribonucleases, and recombination during meiosis in Saccharomyces cerevisiae.
Molecular and cellular biology 1984;4(12):2811-7.
1984: Michael A Resnick; T Chow; John L. Nitiss; J Game
Changes in the chromosomal DNA of yeast during meiosis in repair mutants and the possible role of a deoxyribonuclease.
Cold Spring Harbor symposia on quantitative biology 1984;49():639-49.