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Anthony Reszka

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Marialuisa Micco; Gavin W Collie; Aaron G Dale; Mekala Gunaratnam; Stephan A Ohnmacht; Ingrida Pazitna; Anthony P Reszka; Stephen Neidle
Structure-based design and evaluation of naphthalene diimide g-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.
Sonja M Hampel; Sanjay V Malhotra; Petra Boukamp; Karin M Greulich-Bode; Antonella Pepe; Anthony P Reszka; Sebastian Veith; Stephen Neidle
Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands.
Stephan A Ohnmacht; Vanessa Petrucci; Anthony P Reszka; Alan K Todd; Mire Zloh; Marta A Carvalho; Mekala Gunaratnam; Marialuisa Micco; Stephen Neidle
Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives.

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All Publications

2013: Marialuisa Micco; Gavin W Collie; Aaron G Dale; Mekala Gunaratnam; Stephan A Ohnmacht; Ingrida Pazitna; Anthony P Reszka; Stephen Neidle
Structure-based design and evaluation of naphthalene diimide g-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.
Journal of medicinal chemistry 2013;56(7):2959-74.
2013: Sonja M Hampel; Sanjay V Malhotra; Petra Boukamp; Karin M Greulich-Bode; Antonella Pepe; Anthony P Reszka; Sebastian Veith; Stephen Neidle
Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands.
Molecular pharmacology 2013;83(2):470-80.
2012: Stephan A Ohnmacht; Vanessa Petrucci; Anthony P Reszka; Alan K Todd; Mire Zloh; Marta A Carvalho; Mekala Gunaratnam; Marialuisa Micco; Stephen Neidle
Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives.
Bioorganic & medicinal chemistry letters 2012;22(18):5930-5.
2012: Dengguo Wei; Gary N Parkinson; Anthony P Reszka; Stephen Neidle
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation.
Nucleic acids research 2012;40(10):4691-700.
2012: Khondaker M Rahman; Anthony P Reszka; Stephen Neidle; Karolina Tizkova; David E Thurston
Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries.
Bioorganic & medicinal chemistry letters 2012;22(8):3006-10.
2011: Mekala Gunaratnam; Sonja M Hampel; Anthony P Reszka; Andreas Schätzlein; Alan K Todd; Maria de la Fuente; Stephen Neidle
Targeting pancreatic cancer with a G-quadruplex ligand.
Bioorganic & medicinal chemistry 2011;19(23):7151-7.
2009: Gavin Collie; Anthony P Reszka; haider shozeb; Valérie Gabelica; Gary N Parkinson; Stephen Neidle
Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes.
Chemical communications (Cambridge, England) 2009;(48):7482-4.
2009: Shang-Te Danny Hsu; Peter Varnai; Anthony Bugaut; Anthony P Reszka; Stephen Neidle; Shankar Balasubramanian
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.
Journal of the American Chemical Society 2009;131(37):13399-409.
2009: Mekala Gunaratnam; Stephen Swank; haider shozeb; Katja Galesa; Anthony P Reszka; Monica Beltran; Francisco Cuenca; Jonathan A Fletcher; Stephen Neidle
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.
Journal of medicinal chemistry 2009;52(12):3774-83.
2008: Julie Reed; Mekala Gunaratnam; Monica Beltran; Anthony P Reszka; Ramon Vilar; Stephen Neidle
TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules.
Analytical biochemistry 2008;380(1):99-105.
2008: Nancy Campbell; Gary N Parkinson; Anthony P Reszka; Stephen Neidle
Structural basis of DNA quadruplex recognition by an acridine drug.
Journal of the American Chemical Society 2008;130(21):6722-4.
2007: Mekala Gunaratnam; Olga Greciano; Cristina Martins; Anthony P Reszka; Christoph Schultes; Hamid Morjani; Jean-François Riou; Stephen Neidle
Mechanism of acridine-based telomerase inhibition and telomere shortening.
Biochemical pharmacology 2007;74(5):679-89.
2007: Cristina Martins; Mekala Gunaratnam; John Stuart; Vaidahi Makwana; Olga Greciano; Anthony P Reszka; Lloyd R Kelland; Stephen Neidle
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.
Bioorganic & medicinal chemistry letters 2007;17(8):2293-8.
2006: James E Redman; Sylvain Ladame; Anthony P Reszka; Stephen Neidle; Shankar Balasubramanian
Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library.
Organic & biomolecular chemistry 2006;4(23):4364-9.
2006: Himesh Fernando; Anthony P Reszka; Julian Huppert; Sylvain Ladame; Sarah Rankin; Ashok R Venkitaraman; Stephen Neidle; Shankar Balasubramanian
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene.
Biochemistry 2006;45(25):7854-60.
2005: Sarah Rankin; Anthony P Reszka; Julian Huppert; Mire Zloh; Gary N Parkinson; Alan K Todd; Sylvain Ladame; Shankar Balasubramanian; Stephen Neidle
Putative DNA quadruplex formation within the human c-kit oncogene.
Journal of the American Chemical Society 2005;127(30):10584-9.
2005: Angelika Burger; Fangping Dai; Christoph Schultes; Anthony P Reszka; Michael J Moore; John A Double; Stephen Neidle
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.
Cancer research 2005;65(4):1489-96.
2004: R John Harrison; Anthony P Reszka; haider shozeb; Barbara Romagnoli; James Morrell; Martin A Read; Sharon M Gowan; Christopher M Incles; Lloyd R Kelland; Stephen Neidle
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.
Bioorganic & medicinal chemistry letters 2004;14(23):5845-9.
2003: R John Harrison; Javier Cuesta; Gianni Chessari; Martin A Read; Sanji K Basra; Anthony P Reszka; James Morrell; Sharon M Gowan; Christopher M Incles; Farial A Tanious; David W. Wilson; Lloyd R Kelland; Stephen Neidle
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.
Journal of medicinal chemistry 2003;46(21):4463-76.
2001: J L Li; R John Harrison; Anthony P Reszka; R M Brosh; V A Bohr; Stephen Neidle; Ian D Hickson
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.
Biochemistry 2001;40(50):15194-202.
2001: M Read; R John Harrison; B Romagnoli; Farial A Tanious; S H Gowan; Anthony P Reszka; David W. Wilson; Lloyd R Kelland; Stephen Neidle
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):4844-9.
2000: Stephen Neidle; R John Harrison; Anthony P Reszka; Martin A Read
Structure-activity relationships among guanine-quadruplex telomerase inhibitors.
Pharmacology & therapeutics 2000;85(3):133-9.
1999: Melanie D Keppler; Martin A Read; PJ Perry; John O Trent; TC Jenkins; Anthony P Reszka; Stephen Neidle; Keith R Fox
Stabilization of DNA triple helices by a series of mono- and disubstituted amidoanthraquinones.
European journal of biochemistry / FEBS 1999;263(3):817-25.
1999: PJ Perry; Martin A Read; R T Davies; Sharon M Gowan; Anthony P Reszka; AA Wood; Lloyd R Kelland; Stephen Neidle
2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase.
Journal of medicinal chemistry 1999;42(14):2679-84.
1998: PJ Perry; Anthony P Reszka; AA Wood; Martin A Read; Sharon M Gowan; HS Dosanjh; John O Trent; TC Jenkins; Lloyd R Kelland; Stephen Neidle
Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.
Journal of medicinal chemistry 1998;41(24):4873-84.
1998: PJ Perry; Sharon M Gowan; Anthony P Reszka; Paolo Polucci; TC Jenkins; Lloyd R Kelland; Stephen Neidle
1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.
Journal of medicinal chemistry 1998;41(17):3253-60.
1992: M Agbandje; TC Jenkins; R McKenna; Anthony P Reszka; Stephen Neidle
Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives.
Journal of medicinal chemistry 1992;35(8):1418-29.