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Jean Claude Reubi

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Damian Wild; Pascal Benkert; Jamshed B Bomanji; Peter J Ell; Helmut Maecke; Jean Claude Reubi; Martyn E Caplin
Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT within patients with gastroenteropancreatic neuroendocrine tumors.
Jean Claude Reubi
Old and new peptide receptor targets in cancer: future directions.
Xuejuan Wang; Melpomeni Fani; Jean Claude Reubi; Jean Rivier; Stefan Schulz; Helmut R Maecke
Comprehensive evaluation of a somatostatin-based radiolabelled antagonist for diagnostic imaging and radionuclide therapy.

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2013: Damian Wild; Pascal Benkert; Jamshed B Bomanji; Peter J Ell; Helmut Maecke; Jean Claude Reubi; Martyn E Caplin
Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT within patients with gastroenteropancreatic neuroendocrine tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013;54(3):364-72.
2013: Jean Claude Reubi
Old and new peptide receptor targets in cancer: future directions.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2013;194():567-76.
2012: Xuejuan Wang; Melpomeni Fani; Jean Claude Reubi; Jean Rivier; Stefan Schulz; Helmut R Maecke
Comprehensive evaluation of a somatostatin-based radiolabelled antagonist for diagnostic imaging and radionuclide therapy.
European journal of nuclear medicine and molecular imaging 2012;39(12):1876-85.
2012: Meike Körner; Ruth Rehmann; Jean Claude Reubi
GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease.
Molecular and cellular endocrinology 2012;364(1-2):46-53.
2012: Melpomeni Fani; Helmut R Maecke; Jean E Rivier; Beatrice Waser; Wolfgang A Weber; Karin Beetschen; Friederike Braun; Renzo Cescato; Judit Erchegyi; Jean Claude Reubi
Unexpected sensitivity of sst2 antagonists to N-terminal radiometal modifications.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012;53(9):1481-9.
2012: Beatrice Waser; Agnes Schonbrunn; Renzo Cescato; Emanuel Christ; Yachu J Kao; Meike Körner; Qisheng Liu; Jean Claude Reubi
Phosphorylation of sst2 receptors in neuroendocrine tumors after octreotide treatment of patients.
The American journal of pathology 2012;180(5):1942-9.
2012: Beatrice Waser; Claire Sanchez; Daniel Fourmy; Ruth Rehmann; Jean Claude Reubi
Glucose-dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors.
The Journal of clinical endocrinology and metabolism 2012;97(2):482-8.
2012: Hanwen Zhang; Keelara Abiraj; Michael Honer; Jean Claude Reubi; Peter Smith-Jones; Daniel L J Thorek; Beatrice Waser; Helmut R Maecke
Evolution of bombesin conjugates for targeted PET imaging of tumors.
PloS one 2012;7(9):e44046.
2011: Keelara Abiraj; Renzo Cescato; Melpomeni Fani; Flavio Forrer; Rosalba Mansi; Guillaume Nicolas; Jean Claude Reubi; Maria-Luisa Tamma; Helmut R Maecke
Bombesin antagonist-based radioligands for translational nuclear imaging of gastrin-releasing peptide receptor-positive tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(12):1970-8.
2011: Renzo Cescato; Melpomeni Fani; Beatrice Waser; Jean Claude Reubi
Evaluation of 177Lu-DOTA-sst2 antagonist versus 177Lu-DOTA-sst2 agonist binding in human cancers in vitro.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(12):1886-90.
2011: Judit Erchegyi; Jean E Rivier; Beatrice Waser; Renzo Cescato; Jean Claude Reubi
N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function.
Journal of medicinal chemistry 2011;54(17):5981-7.
2011: Damian Wild; Martin Behe; Ingo Brink; Melpomeni Fani; Helmut R Maecke; Jean Claude Reubi; Jean E F Rivier; Wolfgang A Weber
First clinical evidence that imaging with somatostatin receptor antagonists is feasible.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(9):1412-7.
2011: Meltem Ocak; Petra Kolenc Peitl; C Rangger; Jean Claude Reubi; Jane K Sosabowski; Annemarie Eek; Anna Helbok; Giancarlo Morelli; Berthold A Nock; Wouter A P Breeman; Clemens Decristoforo
Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607.
European journal of nuclear medicine and molecular imaging 2011;38(8):1426-35.
2011: Luigi Aloj; Michela Aurilio; Karin Beetschen; Wouter A P Breeman; Laura D'ambrosio; Erik De Blois; Lieke Joosten; Stuart Koelewijn; Theodosia Maina; Rosalba Mansi; Marleen Melis; Petra Kolenc Peitl; Jean Claude Reubi; Valentina Rinaldi; Jane K Sosabowski; Diego Tesauro; Elisabeth von Guggenberg; Beatrice Waser; Marion De Jong
Comparison of the binding and internalization properties of 12 DOTA-coupled and ¹¹¹In-labelled CCK2/gastrin receptor binding peptides: a collaborative project under COST Action BM0607.
European journal of nuclear medicine and molecular imaging 2011;38(8):1417-25.
2011: Melpomeni Fani; Keelara Abiraj; Renzo Cescato; Luigi Del Pozzo; Rosalba Mansi; Jean Claude Reubi; Maria Luisa Tamma; Beatrice Waser; Wolfgang A Weber; Helmut R Maecke
PET of somatostatin receptor-positive tumors using 64Cu- and 68Ga-somatostatin antagonists: the chelate makes the difference.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(7):1110-8.
2011: Damian Wild; Jochen Seufert; Wolfgang A Weber; Jamshed Bomanji; Michael Brändle; Martyn E Caplin; Emanuel Christ; Peter J Ell; Flavio Forrer; TR Kurzawinski; Aurel Perren; Jean Claude Reubi
Glucagon-like peptide-1 versus somatostatin receptor targeting reveals 2 distinct forms of malignant insulinomas.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(7):1073-8.
2011: Helmut R Maecke; Jean Claude Reubi
Somatostatin receptors as targets for nuclear medicine imaging and radionuclide treatment.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(6):841-4.
2011: Beatrice Waser; Jean Claude Reubi
Value of the radiolabelled GLP-1 receptor antagonist exendin(9-39) for targeting of GLP-1 receptor-expressing pancreatic tissues in mice and humans.
European journal of nuclear medicine and molecular imaging 2011;38(6):1054-8.
2011: Camryn D Allen; Beatrice Waser; Meike Körner; Jean Claude Reubi; Soon Lee; Catherine Rivier
Neuropeptide Y acts within the rat testis to inhibit testosterone secretion.
Neuropeptides 2011;45(1):55-61.
2011: Rosalba Mansi; Xuejuan Wang; Flavio Forrer; Beatrice Waser; Renzo Cescato; Keith Graham; Sandra Borkowski; Jean Claude Reubi; Helmut R Maecke
Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours.
European journal of nuclear medicine and molecular imaging 2011;38(1):97-107.
2010: Emanuel R Christ; Damian Wild; Jean Claude Reubi
Glucagonlike peptide-1 receptor: an example of translational research in insulinomas: a review.
Endocrinology and metabolism clinics of North America 2010;39(4):791-800.
2010: Manu Shastry; Irfan Kayani; Damian Wild; Martyn Caplin; Dimitris Visvikis; Svetislav Gacinovic; Jean Claude Reubi; Jamshed B Bomanji
Distribution pattern of 68Ga-DOTATATE in disease-free patients.
Nuclear medicine communications 2010;31(12):1025-32.
2010: Jean Claude Reubi; A Perren; Ruth Rehmann; Beatrice Waser; Emanuel R Christ; M Callery; A B Goldfine; M E Patti
Glucagon-like peptide-1 (GLP-1) receptors are not overexpressed in pancreatic islets from patients with severe hyperinsulinaemic hypoglycaemia following gastric bypass.
Diabetologia 2010;53(12):2641-5.
2010: Melpomeni Fani; Andreas Mueller; Maria-Luisa Tamma; Guillaume Nicolas; Hans R Rink; Renzo Cescato; Jean Claude Reubi; Helmut R Maecke
Radiolabeled bicyclic somatostatin-based analogs: a novel class of potential radiotracers for SPECT/PET of neuroendocrine tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(11):1771-9.
2010: Beatrice Waser; Renzo Cescato; Maria-Luisa Tamma; Helmut R Maecke; Jean Claude Reubi
Absence of somatostatin SST(2) receptor internalization in vivo after intravenous SOM230 application in the AR42J animal tumor model.
European journal of pharmacology 2010;644(1-3):257-62.
2010: Jean Claude Reubi; Judit Erchegyi; Renzo Cescato; Beatrice Waser; Jean E Rivier
Switch from antagonist to agonist after addition of a DOTA chelator to a somatostatin analog.
European journal of nuclear medicine and molecular imaging 2010;37(8):1551-8.
2010: Alice Laznickova; Milan Laznicek; Frantisek Trejtnar; Helmut R Maecke; Klaus-Peter Eisenwiener; Jean Claude Reubi
Biodistribution of two octreotate analogs radiolabeled with indium and yttrium in rats.
Anticancer research 2010;30(6):2177-84.
2010: Jean Claude Reubi; Beatrice Waser; Renzo Cescato; Beat Gloor; Christoph Stettler; Emanuel R Christ
Internalized somatostatin receptor subtype 2 in neuroendocrine tumors of octreotide-treated patients.
The Journal of clinical endocrinology and metabolism 2010;95(5):2343-50.
2010: Meike Körner; Beatrice Waser; Jean Claude Reubi; Laurence J Miller
CCK(2) receptor splice variant with intron 4 retention in human gastrointestinal and lung tumours.
Journal of cellular and molecular medicine 2010;14(4):933-43.
2010: Keelara Abiraj; Rosalba Mansi; Maria-Luisa Tamma; Flavio Forrer; Renzo Cescato; Jean Claude Reubi; Kayhan G Akyel; Helmut R Maecke
Tetraamine-derived bifunctional chelators for technetium-99m labelling: synthesis, bioconjugation and evaluation as targeted SPECT imaging probes for GRP-receptor-positive tumours.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(7):2115-24.
2010: Renzo Cescato; Kimberly A Loesch; Beatrice Waser; Helmut R Mäcke; Jean E Rivier; Jean Claude Reubi; Agnes Schonbrunn
Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways.
Molecular endocrinology (Baltimore, Md.) 2010;24(1):240-9.
2009: Emanuel R Christ; Damian Wild; Flavio Forrer; Michael Brändle; Rahel Sahli; Thomas Clerici; Beat Gloor; Ferdinand Martius; Helmut Maecke; Jean Claude Reubi
Glucagon-like peptide-1 receptor imaging for localization of insulinomas.
The Journal of clinical endocrinology and metabolism 2009;94(11):4398-405.
2009: Rosalba Mansi; Xuejuan Wang; Flavio Forrer; Stefan Kneifel; Maria-Luisa Tamma; Beatrice Waser; Renzo Cescato; Jean Claude Reubi; Helmut R Maecke
Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(16):5240-9.
2009: Achim Fleischmann; Beatrice Waser; Jean Claude Reubi
High expression of gastrin-releasing peptide receptors in the vascular bed of urinary tract cancers: promising candidates for vascular targeting applications.
Endocrine-related cancer 2009;16(2):623-33.
2009: Beatrice Waser; Maria-Luisa Tamma; Renzo Cescato; Helmut R Maecke; Jean Claude Reubi
Highly efficient in vivo agonist-induced internalization of sst2 receptors in somatostatin target tissues.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(6):936-41.
2009: Judit Erchegyi; Renzo Cescato; Christy Rani R Grace; Beatrice Waser; Véronique Piccand; Daniel Hoyer; Roland Riek; Jean E Rivier; Jean Claude Reubi
Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues.
Journal of medicinal chemistry 2009;52(9):2733-46.
2009: Eyup Akgün; Meike Körner; Fan Gao; Kaleeckal harikumar; Beatrice Waser; Jean Claude Reubi; Philip S Portoghese; Laurence J Miller
Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors.
Journal of medicinal chemistry 2009;52(7):2138-47.
2009: Debby Feytens; Magali De Vlaeminck; Renzo Cescato; Dirk Tourwé; Jean Claude Reubi
Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities.
Journal of medicinal chemistry 2009;52(1):95-104.
2008: Christy Rani R Grace; Judit Erchegyi; Jean Claude Reubi; Jean E Rivier; Roland Riek
Three-dimensional consensus structure of sst2-selective somatostatin (SRIF) antagonists by NMR.
Biopolymers 2008;89(12):1077-87.
2008: Jean Claude Reubi; Helmut R Maecke
Peptide-based probes for cancer imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(11):1735-8.
2008: Stela S Palii; Aqeela Afzal; Lynn C Shaw; Hao Pan; Sergio Caballero; Rehae C Miller; Simona Jurczyk; Jean Claude Reubi; Yufei Tan; Guenther Hochhaus; Henry F Edelhauser; Dayle Geroski; Gideon Shapiro; Maria B Grant
Nonpeptide somatostatin receptor agonists specifically target ocular neovascularization via the somatostatin type 2 receptor.
Investigative ophthalmology & visual science 2008;49(11):5094-102.
2008: Stephan Good; Martin A Walter; Beatrice Waser; Xuejuan Wang; Jan Müller-Brand; Martin Béhé; Jean Claude Reubi; Helmut R Maecke
Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours.
European journal of nuclear medicine and molecular imaging 2008;35(10):1868-77.
2008: Meike Körner; Beatrice Waser; Jean Claude Reubi
High expression of neuropeptide Y1 receptors in ewing sarcoma tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(16):5043-9.
2008: Damian Wild; Helmut Mäcke; Emanuel Christ; Beat Gloor; Jean Claude Reubi
Glucagon-like peptide 1-receptor scans to localize occult insulinomas.
The New England journal of medicine 2008;359(7):766-8.
2008: Meike Körner; Jean Claude Reubi
Neuropeptide Y receptors in primary human brain tumors: overexpression in high-grade tumors.
Journal of neuropathology and experimental neurology 2008;67(8):741-9.
2008: Renzo Cescato; Judit Erchegyi; Beatrice Waser; Véronique Piccand; Helmut R Maecke; Jean E Rivier; Jean Claude Reubi
Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting.
Journal of medicinal chemistry 2008;51(13):4030-7.
2008: Judit Erchegyi; Christy Rani R Grace; Manoj P Samant; Renzo Cescato; Veronique Piccand; Roland Riek; Jean Claude Reubi; Jean E Rivier
Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.
Journal of medicinal chemistry 2008;51(9):2668-75.
2008: Christy Rani R Grace; Judit Erchegyi; Manoj P Samant; Renzo Cescato; Veronique Piccand; Roland Riek; Jean Claude Reubi; Jean E Rivier
Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity.
Journal of medicinal chemistry 2008;51(9):2676-81.
2008: Mihaela Ginj; Hanwen Zhang; Klaus-Peter Eisenwiener; Damian Wild; Stefan Schulz; Hans Rink; Renzo Cescato; Jean Claude Reubi; Helmut R Maecke
New pansomatostatin ligands and their chelated versions: affinity profile, agonist activity, internalization, and tumor targeting.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2019-27.
2008: Meike U Körner; Gregory M Hayes; patricia carrigan; Ruth Rehmann; Laurence J Miller; Jean Claude Reubi
Wild-type and splice-variant secretin receptors in lung cancer: overexpression in carcinoid tumors and peritumoral lung tissue.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008;21(4):387-95.
2008: Debora D'Addona; Alfonso Carotenuto; Ettore Novellino; Véronique Piccand; Jean Claude Reubi; Alessandra Di Cianni; Francesca Gori; Anna Maria Papini; Mauro Ginanneschi
Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships.
Journal of medicinal chemistry 2008;51(3):512-20.
2008: Renzo Cescato; Theodosia Maina; Berthold Nock; Anastasia Nikolopoulou; David Charalambidis; Véronique Piccand; Jean Claude Reubi
Bombesin receptor antagonists may be preferable to agonists for tumor targeting.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(2):318-26.
2008: Axel Heppeler; João P André; Ingeborg Buschmann; Xuejuan Wang; Jean Claude Reubi; Michael Hennig; Thomas A Kaden; Helmut R Maecke
Metal-ion-dependent biological properties of a chelator-derived somatostatin analogue for tumour targeting.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(10):3026-34.
2008: Mathias Gugger; Richard White; Susan Song; Beatrice Waser; Renzo Cescato; Pierre Rivière; Jean Claude Reubi
GPR87 is an overexpressed G-protein coupled receptor in squamous cell carcinoma of the lung.
Disease markers 2008;24(1):41-50.
2007: Marleen Melis; Flavio Forrer; Astrid Capello; Magda Bijster; Bert F Bernard; Jean Claude Reubi; Eric P Krenning; Marion De Jong
Up-regulation of somatostatin receptor density on rat CA20948 tumors escaped from low dose [177Lu-DOTA0,Tyr3]octreotate therapy.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology 2007;51(4):324-33.
2007: Gregory M Hayes; patricia carrigan; Maoqing Dong; Jean Claude Reubi; Laurence J Miller
A novel secretin receptor splice variant potentially useful for early diagnosis of pancreatic carcinoma.
Gastroenterology 2007;133(3):853-61.
2007: Jean Claude Reubi
Peptide receptor expression in GEP-NET.
Virchows Archiv : an international journal of pathology 2007;451 Suppl 1():S47-50.
2007: Monique de Visser; H F Bernard; Jack Erion; Michelle A Schmidt; Ananth Srinivasan; B Waser; Jean Claude Reubi; Eric P Krenning; Marion De Jong
Novel 111In-labelled bombesin analogues for molecular imaging of prostate tumours.
European journal of nuclear medicine and molecular imaging 2007;34(8):1228-38.
2007: Hanwen Zhang; Jochen Schuhmacher; Beatrice Waser; Damian Wild; Michael Eisenhut; Jean Claude Reubi; Helmut R Maecke
DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours.
European journal of nuclear medicine and molecular imaging 2007;34(8):1198-208.
2007: Debby Feytens; Renzo Cescato; Jean Claude Reubi; Dirk Tourwé
New sst4/5-selective somatostatin peptidomimetics based on a constrained tryptophan scaffold.
Journal of medicinal chemistry 2007;50(14):3397-401.
2007: Patricia Antunes; Mihaela Ginj; Hanwen Zhang; Beatrice Waser; R P Baum; Jean Claude Reubi; Helmut R Maecke
Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?
European journal of nuclear medicine and molecular imaging 2007;34(7):982-93.
2007: Andreas Wicki; Damian Wild; Daniel Storch; Christian Seemayer; Martin Gotthardt; Martin Behe; Stefan Kneifel; Michael J Mihatsch; Jean Claude Reubi; Helmut R Mäcke; Gerhard Christofori
[Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(12):3696-705.
2007: Meike Körner; Martin Stöckli; Beatrice Waser; Jean Claude Reubi
GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007;48(5):736-43.
2007: Meike Körner; Jean Claude Reubi
NPY receptors in human cancer: a review of current knowledge.
Peptides 2007;28(2):419-25.
2007: Achim Fleischmann; Beatrice Waser; Jean Claude Reubi
Overexpression of gastrin-releasing peptide receptors in tumor-associated blood vessels of human ovarian neoplasms.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2007;29(5):421-33.
2007: Jean Claude Reubi
Targeting CCK receptors in human cancers.
Current topics in medicinal chemistry 2007;7(12):1239-42.
2007: Patricia Fainstein Day; Lawrence A Frohman; HERNAN GARCIA RIVELLO; Jean Claude Reubi; Gustavo Sevlever; Mariela Glerean; Tomas Fernandez Gianotti; Marcelo Pietrani; Alejandra Rabadan; Silvina Racioppi; Martin Bidlingmaier
Ectopic growth hormone-releasing hormone secretion by a metastatic bronchial carcinoid tumor: a case with a non hypophysial intracranial tumor that shrank during long acting octreotide treatment.
Pituitary 2007;10(3):311-9.
2007: Patricia Antunes; Mihaela Ginj; Martin A Walter; Jianhua Chen; Jean Claude Reubi; Helmut R Maecke
Influence of different spacers on the biological profile of a DOTA-somatostatin analogue.
Bioconjugate chemistry 2007;18(1):84-92.
2007: Beatrice Waser; Véronique Eltschinger; Karen Linder; Adrian Nunn; Jean Claude Reubi
Selective in vitro targeting of GRP and NMB receptors in human tumours with the new bombesin tracer 177Lu-AMBA.
European journal of nuclear medicine and molecular imaging 2007;34(1):95-100.
2006: Damian Wild; Martin Béhé; Andreas Wicki; Daniel Storch; Beatrice Waser; Martin Gotthardt; Boris Keil; Gerhard Christofori; Jean Claude Reubi; Helmut R Mäcke
[Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(12):2025-33.
2006: Meike Körner; Gregory M Hayes; Ruth Rehmann; Arthur Zimmermann; Arne Scholz; Bertram Wiedenmann; Laurence J Miller; Jean Claude Reubi
Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma.
Journal of hepatology 2006;45(6):825-35.
2006: Beatrice Waser; Ruth Rehmann; Jean Rivier; Wylie Vale; Jean Claude Reubi
CRF receptors in the rodent and human cardiovascular systems: species differences.
Peptides 2006;27(12):3029-38.
2006: Mihaela Ginj; Hanwen Zhang; Beatrice Waser; Renzo Cescato; Damian Wild; Xuejuan Wang; Judit Erchegyi; Jean Rivier; Helmut R Mäcke; Jean Claude Reubi
Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16436-41.
2006: Mihaela Ginj; Jörg S Schmitt; Jianhua Chen; Beatrice Waser; Jean Claude Reubi; Marion de Jong; Stefan Schulz; Helmut R Maecke
Design, synthesis, and biological evaluation of somatostatin-based radiopeptides.
Chemistry & biology 2006;13(10):1081-90.
2006: Rachida Lebtahi; Severine Moreau; Sylvain Marchand-Adam; Marie-Pierre Debray; Michel Brauner; Paul Soler; Joëlle Marchal; Olivier Raguin; Anne Gruaz-Guyon; Jean Claude Reubi; Dominique Le Guludec; Bruno Crestani
Increased uptake of 111In-octreotide in idiopathic pulmonary fibrosis.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(8):1281-7.
2006: Berthold A Nock; Anastasia Nikolopoulou; Jean Claude Reubi; Veronique Maes; Peter Conrath; Dirk Tourwé; Theodosia Maina
Toward stable N4-modified neurotensins for NTS1-receptor-targeted tumor imaging with 99mTc.
Journal of medicinal chemistry 2006;49(15):4767-76.
2006: Christy Rani R Grace; Judit Erchegyi; Steven C Koerber; Jean Claude Reubi; Jean Rivier; Roland Riek
Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR.
Journal of medicinal chemistry 2006;49(15):4487-96.
2006: Laura E Lantry; Enrico Cappelletti; Mary Ellen Maddalena; Jaclyn S Fox; Weiwei Feng; Jianqing Chen; Regi Thomas; Stephen M Eaton; Nancy J Bogdan; Thangavel Arunachalam; Jean Claude Reubi; Natarajan Raju; Edmund C Metcalfe; Luciano Lattuada; Karen Linder; Rolf E Swenson; Michael Tweedle; Adrian Nunn
177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(7):1144-52.
2006: Theodosia Maina; Berthold A Nock; Paul Cordopatis; Bert F Bernard; Wouter A P Breeman; Arthur van Gameren; Ria van den Berg; Jean Claude Reubi; Eric P Krenning; Marion De Jong
[(99m)Tc]Demotate 2 in the detection of sst(2)-positive tumours: a preclinical comparison with [(111)In]DOTA-tate.
European journal of nuclear medicine and molecular imaging 2006;33(7):831-40.
2006: Stefan Kneifel; Dominik Cordier; Stephan Good; Mihai C S Ionescu; Anthony Ghaffari; Silvia Hofer; Martin Kretzschmar; Markus Tolnay; Christos Apostolidis; Beatrice Waser; Marlene Arnold; Jan Mueller-Brand; Helmut R Maecke; Jean Claude Reubi; Adrian Merlo
Local targeting of malignant gliomas by the diffusible peptidic vector 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-substance p.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(12):3843-50.
2006: Adrian Schmassmann; Georg Zoidl; Brigitta M Peskar; Beatrice Waser; Diana Schmassmann-Suhijar; Jan-Olaf Gebbers; Jean Claude Reubi
Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(4):G747-56.
2006: Renzo Cescato; Stefan Schulz; Beatrice Waser; Véronique Eltschinger; Jean E Rivier; Hans-Jürgen Wester; Michael Culler; Mihaela Ginj; Qisheng Liu; Agnes Schonbrunn; Jean Claude Reubi
Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(3):502-11.
2006: Margarida Gairí; Pilar Saiz; Sergio Madurga; Xavier Roig; Judit Erchegyi; Steven C Koerber; Jean Claude Reubi; Jean E Rivier; Ernest Giralt
Conformational analysis of a potent SSTR3-selective somatostatin analogue by NMR in water solution.
Journal of peptide science : an official publication of the European Peptide Society 2006;12(2):82-91.
2005: Meike Körner; Véronique Eltschinger; Beatrice Waser; Agnes Schonbrunn; Jean Claude Reubi
Value of immunohistochemistry for somatostatin receptor subtype sst2A in cancer tissues: lessons from the comparison of anti-sst2A antibodies with somatostatin receptor autoradiography.
The American journal of surgical pathology 2005;29(12):1642-51.
2005: Astrid Capello; Eric P Krenning; Bert Bernard; Jean Claude Reubi; Wouter A P Breeman; Marion De Jong
111In-labelled somatostatin analogues in a rat tumour model: somatostatin receptor status and effects of peptide receptor radionuclide therapy.
European journal of nuclear medicine and molecular imaging 2005;32(11):1288-95.
2005: Meike Körner; Gregory M Hayes; Ruth Rehmann; Arthur Zimmermann; Helmut Friess; Laurence J Miller; Jean Claude Reubi
Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia.
The American journal of pathology 2005;167(4):959-68.
2005: Achim Fleischmann; Beatrice Waser; Jan-Olaf Gebbers; Jean Claude Reubi
Gastrin-releasing peptide receptors in normal and neoplastic human uterus: involvement of multiple tissue compartments.
The Journal of clinical endocrinology and metabolism 2005;90(8):4722-9.
2005: Meike Körner; Beatrice Waser; Jean Claude Reubi
Neuropeptide Y receptors in renal cell carcinomas and nephroblastomas.
International journal of cancer. Journal international du cancer 2005;115(5):734-41.
2005: Qisheng Liu; Renzo Cescato; Dian A Dewi; Jean Rivier; Jean Claude Reubi; Agnes Schonbrunn
Receptor signaling and endocytosis are differentially regulated by somatostatin analogs.
Molecular pharmacology 2005;68(1):90-101.
2005: Damian Wild; Helmut R Mäcke; Beatrice Waser; Jean Claude Reubi; Mihaela Ginj; Helmut Rasch; Jan Müller-Brand; Michael Hofmann
68Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5.
European journal of nuclear medicine and molecular imaging 2005;32(6):724.
2005: Theodosia Maina; Berthold A Nock; Hanwen Zhang; Anastasia Nikolopoulou; Beatrice Waser; Jean Claude Reubi; Helmut R Maecke
Species differences of bombesin analog interactions with GRP-R define the choice of animal models in the development of GRP-R-targeting drugs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(5):823-30.
2005: Margret Schottelius; Jean Claude Reubi; Véronique Eltschinger; Markus Schwaiger; Hans-Jürgen Wester
N-terminal sugar conjugation and C-terminal Thr-for-Thr(ol) exchange in radioiodinated Tyr3-octreotide: effect on cellular ligand trafficking in vitro and tumor accumulation in vivo.
Journal of medicinal chemistry 2005;48(8):2778-89.
2005: Oliver A Garden; Jean Claude Reubi; Nathan L Dykes; Amy E Yeager; Sean P McDonough; kenneth simpson
Somatostatin receptor imaging in vivo by planar scintigraphy facilitates the diagnosis of canine insulinomas.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2005;19(2):168-76.
2005: Margret Schottelius; Friederike C Rau; Jean Claude Reubi; Markus Schwaiger; Hans-Jürgen Wester
Modulation of pharmacokinetics of radioiodinated sugar-conjugated somatostatin analogues by variation of peptide net charge and carbohydration chemistry.
Bioconjugate chemistry 2005;16(2):429-37.
2005: Daniel Beutler; Pierino Avoledo; Jean Claude Reubi; Helmut R Mäcke; Jan Müller-Brand; Adrian Merlo; Thomas Kühne
Three-year recurrence-free survival in a patient with recurrent medulloblastoma after resection, high-dose chemotherapy, and intrathecal Yttrium-90-labeled DOTA0-D-Phe1-Tyr3-octreotide radiopeptide brachytherapy.
Cancer 2005;103(4):869-73.
2005: Mihaela Ginj; Jianhua Chen; Martin A Walter; Véronique Eltschinger; Jean Claude Reubi; Helmut R Maecke
Preclinical evaluation of new and highly potent analogues of octreotide for predictive imaging and targeted radiotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1136-45.
2005: Christy Rani R Grace; Lukas Durrer; Steven C Koerber; Judit Erchegyi; Jean Claude Reubi; Jean E Rivier; Roland Riek
Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR.
Journal of medicinal chemistry 2005;48(2):523-33.
2005: Jean E Rivier; Dean A Kirby; Judit Erchegyi; Beatrice Waser; Véronique Eltschinger; Renzo Cescato; Jean Claude Reubi
Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides.
Journal of medicinal chemistry 2005;48(2):515-22.
2005: Judit Erchegyi; Carl A Hoeger; William Low; Daniel Hoyer; Beatrice Waser; Véronique Eltschinger; Jean-Claude Schaer; Renzo Cescato; Jean Claude Reubi; Jean E Rivier
Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan.
Journal of medicinal chemistry 2005;48(2):507-14.
2005: Berthold A Nock; Anastasia Nikolopoulou; Athanassios S Galanis; Paul Cordopatis; Beatrice Waser; Jean Claude Reubi; Theodosia Maina
Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study.
Journal of medicinal chemistry 2005;48(1):100-10.
2005: Eric P Krenning; Roelf Valkema; Dik J Kwekkeboom; Wouter W de Herder; C H J van Eijck; Marion De Jong; Stanislas Pauwels; Jean Claude Reubi
Molecular imaging as in vivo molecular pathology for gastroenteropancreatic neuroendocrine tumors: implications for follow-up after therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46 Suppl 1():76S-82S.
2005: Jean Claude Reubi; Helmut R Mäcke; Eric P Krenning
Candidates for peptide receptor radiotherapy today and in the future.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46 Suppl 1():67S-75S.
2004: Meike Körner; Beatrice Waser; Jean Claude Reubi
High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8426-33.
2004: Mathias Gugger; Beatrice Waser; Andreas Kappeler; Agnes Schonbrunn; Jean Claude Reubi
Cellular detection of sst2A receptors in human gastrointestinal tissue.
Gut 2004;53(10):1431-6.
2004: Hanwen Zhang; Jianhua Chen; Christian Waldherr; Karin Hinni; Beatrice Waser; Jean Claude Reubi; Helmut R Maecke
Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors.
Cancer research 2004;64(18):6707-15.
2004: Jean Claude Reubi; Pernille Koefoed; Thomas v O Hansen; Edouard Stauffer; Daniel Rauch; Omid Niazi; Jens F Rehfeld
Procholecystokinin as marker of human Ewing sarcomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(16):5523-30.
2004: Marion De Jong; Roelf Valkema; Arthur van Gameren; Hester Van Boven; Axel Bex; Eric Pieter Van De Weyer; Jan Dirk Burggraaf; Meike Körner; Jean Claude Reubi; Eric P Krenning
Inhomogeneous localization of radioactivity in the human kidney after injection of [(111)In-DTPA]octreotide.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(7):1168-71.
2004: Margret Schottelius; Thorsten Poethko; Michael Herz; Jean Claude Reubi; Horst Kessler; Markus Schwaiger; Hans-Jürgen Wester
First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3593-606.
2004: Jean Claude Reubi; Meike Körner; Beatrice Waser; Luca Mazzucchelli; Louis Guillou
High expression of peptide receptors as a novel target in gastrointestinal stromal tumours.
European journal of nuclear medicine and molecular imaging 2004;31(6):803-10.
2004: Mathias Gugger; Beatrice Waser; Andreas Kappeler; Agnes Schonbrunn; Jean Claude Reubi
Immunohistochemical localization of somatostatin receptor sst2A in human gut and lung tissue: possible implications for physiology and carcinogenesis.
Annals of the New York Academy of Sciences 2004;1014():132-6.
2004: Robert H Jones; Jean Claude Reubi; David Millan; Paul A Vasey
Octreotide: an active agent in epithelial ovarian carcinoma?
The lancet oncology 2004;5(4):251-3.
2004: Adrian Schmassmann; Beatrice Waser; Beatrice Flogerzi; Jean Claude Reubi
Expression of functional neurokinin-1 receptors in regenerative glands during gastric wound healing in rodents.
Gastroenterology 2004;126(3):784-95.
2004: Anthony J Harmar; W John Sheward; Christine F Morrison; Beatrice Waser; Mathias Gugger; Jean Claude Reubi
Distribution of the VPAC2 receptor in peripheral tissues of the mouse.
Endocrinology 2004;145(3):1203-10.
2004: Jean Claude Reubi
Somatostatin and other Peptide receptors as tools for tumor diagnosis and treatment.
Neuroendocrinology 2004;80 Suppl 1():51-6.
2004: Meike Körner; Beatrice Waser; Jean Claude Reubi
Neuropeptide Y receptor expression in human primary ovarian neoplasms.
Laboratory investigation; a journal of technical methods and pathology 2004;84(1):71-80.
2003: Christy Rani R Grace; Steven C Koerber; Judit Erchegyi; Jean Claude Reubi; Jean Rivier; Roland Riek
Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR.
Journal of medicinal chemistry 2003;46(26):5606-18.
2003: Judit Erchegyi; Beatrice Waser; Jean-Claude Schaer; Renzo Cescato; Jean François Brazeau; Jean Rivier; Jean Claude Reubi
Novel sst(4)-selective somatostatin (SRIF) agonists. 3. Analogues amenable to radiolabeling.
Journal of medicinal chemistry 2003;46(26):5597-605.
2003: Judit Erchegyi; Botond Penke; Lajos Simon; Scott Michaelson; Sandra Wenger; Beatrice Waser; Renzo Cescato; Jean-Claude Schaer; Jean Claude Reubi; Jean Rivier
Novel sst(4)-selective somatostatin (SRIF) agonists. 2. Analogues with beta-methyl-3-(2-naphthyl)alanine substitutions at position 8.
Journal of medicinal chemistry 2003;46(26):5587-96.
2003: Jean Rivier; Judit Erchegyi; Carl A Hoeger; Charleen Miller; William Low; Sandra Wenger; Beatrice Waser; Jean-Claude Schaer; Jean Claude Reubi
Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan.
Journal of medicinal chemistry 2003;46(26):5579-86.
2003: Qisheng Liu; Jean Claude Reubi; Yining Wang; Brian J Knoll; Agnes Schonbrunn
In vivo phosphorylation of the somatostatin 2A receptor in human tumors.
The Journal of clinical endocrinology and metabolism 2003;88(12):6073-9.
2003: Damian Wild; Jörg S Schmitt; Mihaela Ginj; Helmut R Mäcke; Bert F Bernard; Eric Krenning; Marion De Jong; Sandra Wenger; Jean Claude Reubi
DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals.
European journal of nuclear medicine and molecular imaging 2003;30(10):1338-47.
2003: Jean Claude Reubi
Peptide receptors as molecular targets for cancer diagnosis and therapy.
Endocrine reviews 2003;24(4):389-427.
2003: Leo J Hofland; Steven W J Lamberts; P Martin van Hagen; Jean Claude Reubi; James Schaeffer; Marlijn Waaijers; Peter M Van Koetsveld; Ananth Srinivasan; Eric P Krenning; Wouter A P Breeman
Crucial role for somatostatin receptor subtype 2 in determining the uptake of [111In-DTPA-D-Phe1]octreotide in somatostatin receptor-positive organs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(8):1315-21.
2003: Monique de Visser; P J J M Janssen; Ananth Srinivasan; Jean Claude Reubi; B Waser; Jack Erion; Michelle A Schmidt; Eric P Krenning; Marion De Jong
Stabilised 111In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer.
European journal of nuclear medicine and molecular imaging 2003;30(8):1134-9.
2003: Jean Claude Reubi; Beatrice Waser; Mathias Gugger; Helmut Friess; Jörg Kleeff; Hany Kayed; Markus W Büchler; Jean A Laissue
Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue.
Gastroenterology 2003;125(1):98-106.
2003: Jean Claude Reubi; Beatrice Waser; Wylie Vale; Jean Rivier
Expression of CRF1 and CRF2 receptors in human cancers.
The Journal of clinical endocrinology and metabolism 2003;88(7):3312-20.
2003: Helmut Friess; Zhaowen Zhu; Veronique Liard; Xin Shi; Shailesh Shrikhande; Li Wang; Klaus Lieb; Murray Korc; Carla Palma; Arthur Zimmermann; Jean Claude Reubi; Markus W Büchler
Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer.
Laboratory investigation; a journal of technical methods and pathology 2003;83(5):731-42.
2003: Jean Claude Reubi; Beatrice Waser
Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting.
European journal of nuclear medicine and molecular imaging 2003;30(5):781-93.
2003: Berthold A Nock; Anastasia Nikolopoulou; Efstratios Chiotellis; George Loudos; Dimitrios Maintas; Jean Claude Reubi; Theodosia Maina
[99mTc]Demobesin 1, a novel potent bombesin analogue for GRP receptor-targeted tumour imaging.
European journal of nuclear medicine and molecular imaging 2003;30(2):247-58.
2003: Hans-Jürgen Wester; Margret Schottelius; Klemens Scheidhauer; Günther Meisetschläger; Michael Herz; Friederike C Rau; Jean Claude Reubi; Markus Schwaiger
PET imaging of somatostatin receptors: design, synthesis and preclinical evaluation of a novel 18F-labelled, carbohydrated analogue of octreotide.
European journal of nuclear medicine and molecular imaging 2003;30(1):117-22.
2002: Jean Claude Reubi; Klaus-Peter Eisenwiener; Hans Rink; Beatrice Waser; Helmut R Mäcke
A new peptidic somatostatin agonist with high affinity to all five somatostatin receptors.
European journal of pharmacology 2002;456(1-3):45-9.
2002: Kwok Seng Loh; Beatrice Waser; Luke K S Tan; Run Sheng Ruan; Edouard Stauffer; Jean Claude Reubi
Somatostatin receptors in nasopharyngeal carcinoma.
Virchows Archiv : an international journal of pathology 2002;441(5):444-8.
2002: Jean Rivier; Jozsef Gulyas; D Kirby; William Low; Marilyn H Perrin; Koichi S Kunitake; Michael R DiGruccio; Joan Vaughan; Jean Claude Reubi; Beatrice Waser; Steven C Koerber; Vicente Martinez; L Wang; Yvette Taché; Wylie Vale
Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists.
Journal of medicinal chemistry 2002;45(21):4737-47.
2002: Milan Laznicek; Alice Laznickova; Helmut R Mäcke; Klaus-Peter Eisenwiener; Jean Claude Reubi; Sandra Wenger
Octreotide and octreotate derivatives radiolabeled with yttrium: pharmacokinetics in rats.
Cancer biotherapy & radiopharmaceuticals 2002;17(5):527-33.
2002: Margret Schottelius; Hans-Jürgen Wester; Jean Claude Reubi; Reingard Senekowitsch-Schmidtke; Markus Schwaiger
Improvement of pharmacokinetics of radioiodinated Tyr(3)-octreotide by conjugation with carbohydrates.
Bioconjugate chemistry 2002;13(5):1021-30.
2002: Anthony J Harmar; Hugh M Marston; Sanbing Shen; Christopher Spratt; Katrine M West; W John Sheward; Christine F Morrison; Julia R Dorin; Hugh D Piggins; Jean Claude Reubi; John S Kelly; Elizabeth S Maywood; Michael H Hastings
The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei.
Cell 2002;109(4):497-508.
2002: Klaus-Peter Eisenwiener; M I M Prata; I Buschmann; Han-Wen Zhang; A C Santos; Sandra Wenger; Jean Claude Reubi; Helmut R Mäcke
NODAGATOC, a new chelator-coupled somatostatin analogue labeled with [67/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors.
Bioconjugate chemistry 2002;13(3):530-41.
2002: Jean Claude Reubi; Sandra Wenger; Jacqueline Schmuckli-Maurer; Jean-Claude Schaer; Mathias Gugger
Bombesin receptor subtypes in human cancers: detection with the universal radioligand (125)I-[D-TYR(6), beta-ALA(11), PHE(13), NLE(14)] bombesin(6-14).
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):1139-46.
2002: Tilmann Schumacher; Silvia Hofer; K Eichhorn; Morten Wasner; S Zimmerer; Peter Freitag; A Probst; Otmar Gratzl; Jean Claude Reubi; R Maecke; Jan Mueller-Brand; Adrian Merlo
Local injection of the 90Y-labelled peptidic vector DOTATOC to control gliomas of WHO grades II and III: an extended pilot study.
European journal of nuclear medicine and molecular imaging 2002;29(4):486-93.
2002: Hans-Jürgen Wester; Margret Schottelius; Klemens Scheidhauer; Jean Claude Reubi; Ingo Wolf; Markus Schwaiger
Comparison of radioiodinated TOC, TOCA and Mtr-TOCA: the effect of carbohydration on the pharmacokinetics.
European journal of nuclear medicine and molecular imaging 2002;29(1):28-38.
2002: Ralf Bergmann; Matthias Scheunemann; Christoph Heichert; Peter Mäding; Holm Wittrisch; Marion Kretzschmar; Heike Rodig; Dirk Tourwé; Koen Iterbeke; Kris Chavatte; Daniel Zips; Jean Claude Reubi; Bernd Johannsen
Biodistribution and catabolism of (18)F-labeled neurotensin(8-13) analogs.
Nuclear medicine and biology 2002;29(1):61-72.
2001: Silvia Hofer; K Eichhorn; Peter Freitag; Jean Claude Reubi; J Muller-Brand; Helmut R Maecke; Adrian Merlo
Successful diffusible brachytherapy (dBT) of a progressive low-grade astrocytoma using the locally injected peptidic vector and somatostatin analogue [90Y]-DOTA0-D-Phe1-Tyr3-octreotide (DOTATOC).
Swiss medical weekly 2001;131(43-44):640-4.
2001: Jean Claude Reubi; Beatrice Waser; Jean-Claude Schaer; Jean A Laissue
Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands.
European journal of nuclear medicine 2001;28(7):836-46.
2001: Jean E Rivier; Carl A Hoeger; Judit Erchegyi; Jozsef Gulyas; R DeBoard; A Grey Craig; Steven C Koerber; Sandra Wenger; Beatrice Waser; Jean-Claude Schaer; Jean Claude Reubi
Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1).
Journal of medicinal chemistry 2001;44(13):2238-46.
2001: Jean Claude Reubi; Mathias Gugger; Beatrice Waser; Jean-Claude Schaer
Y(1)-mediated effect of neuropeptide Y in cancer: breast carcinomas as targets.
Cancer research 2001;61(11):4636-41.
2001: Jean Claude Reubi
CCK receptors in human neuroendocrine tumors: clinical implications.
Scandinavian journal of clinical and laboratory investigation. Supplementum 2001;234():101-4.
2000: Jean Claude Reubi; Jean-Claude Schaer; Sandra Wenger; Carl A Hoeger; Judit Erchegyi; Beatrice Waser; Jean Rivier
SST3-selective potent peptidic somatostatin receptor antagonists.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13973-8.
2000: Achim Fleischmann; U Läderach; Helmut Friess; M W Buechler; Jean Claude Reubi
Bombesin receptors in distinct tissue compartments of human pancreatic diseases.
Laboratory investigation; a journal of technical methods and pathology 2000;80(12):1807-17.
2000: Jean Claude Reubi; Beatrice Waser; Qisheng Liu; Jean A Laissue; Agnes Schonbrunn
Subcellular distribution of somatostatin sst2A receptors in human tumors of the nervous and neuroendocrine systems: membranous versus intracellular location.
The Journal of clinical endocrinology and metabolism 2000;85(10):3882-91.
2000: Adrian Schmassmann; Jean Claude Reubi
Cholecystokinin-B/gastrin receptors enhance wound healing in the rat gastric mucosa.
The Journal of clinical investigation 2000;106(8):1021-9.
2000: Dik J Kwekkeboom; Willem H Bakker; Peter P M Kooij; Jack Erion; Ananth Srinivasan; Marion De Jong; Jean Claude Reubi; Eric P Krenning
Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma.
European journal of nuclear medicine 2000;27(9):1312-7.
2000: Jean Claude Reubi; U Läderach; Beatrice Waser; Jan-Olaf Gebbers; P Robberecht; Jean A Laissue
Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin.
Cancer research 2000;60(11):3105-12.
2000: Jean Claude Reubi; J C Schär; Beatrice Waser; Sandra Wenger; Axel Heppeler; Jörg S Schmitt; Helmut R Mäcke
Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use.
European journal of nuclear medicine 2000;27(3):273-82.
2000: Li Wang; Helmut Friess; Z Zhu; Hans U Graber; Arthur Zimmermann; Murray Korc; Jean Claude Reubi; Markus W Büchler
Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):566-71.
2000: Jean Claude Reubi
In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications.
Annals of the New York Academy of Sciences 2000;921():1-25.
1999: Marion De Jong; Willem H Bakker; Bert F Bernard; Roelf Valkema; Dik J Kwekkeboom; Jean Claude Reubi; Ananth Srinivasan; Michelle Schmidt; Eric P Krenning
Preclinical and initial clinical evaluation of 111In-labeled nonsulfated CCK8 analog: a peptide for CCK-B receptor-targeted scintigraphy and radionuclide therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(12):2081-7.
1999: Mathias Gugger; Jean Claude Reubi
Gastrin-releasing peptide receptors in non-neoplastic and neoplastic human breast.
The American journal of pathology 1999;155(6):2067-76.
1999: Jean Claude Reubi; Arthur Zimmermann; S Jonas; Beatrice Waser; P Neuhaus; U Läderach; Bertram Wiedenmann
Regulatory peptide receptors in human hepatocellular carcinomas.
Gut 1999;45(5):766-74.
1999: Jean Claude Reubi; Jean A Laissue; Beatrice Waser; D L Steffen; R William Hipkin; Agnes Schonbrunn
Immunohistochemical detection of somatostatin sst2a receptors in the lymphatic, smooth muscular, and peripheral nervous systems of the human gastrointestinal tract: facts and artifacts.
The Journal of clinical endocrinology and metabolism 1999;84(8):2942-50.
1999: Jean Claude Reubi; Beatrice Waser; Jean-Claude Schaer; Jean A Laissue
Neurotensin receptors in human neoplasms: high incidence in Ewing's sarcomas.
International journal of cancer. Journal international du cancer 1999;82(2):213-8.
1999: Jean Claude Reubi; Beatrice Waser; Adrian Schmassmann; Jean A Laissue
Receptor autoradiographic evaluation of cholecystokinin, neurotensin, somatostatin and vasoactive intestinal peptide receptors in gastro-intestinal adenocarcinoma samples: where are they really located?
International journal of cancer. Journal international du cancer 1999;81(3):376-86.
1999: Adrian Merlo; Oliver Hausmann; Morten Wasner; P Steiner; Andreas Otte; E Jermann; Peter Freitag; Jean Claude Reubi; Jan Müller-Brand; Otmar Gratzl; Helmut R Mäcke
Locoregional regulatory peptide receptor targeting with the diffusible somatostatin analogue 90Y-labeled DOTA0-D-Phe1-Tyr3-octreotide (DOTATOC): a pilot study in human gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(5):1025-33.
1999: Marcus E Martignoni; Helmut Friess; D Lübke; Waldemar Uhl; C Maurer; M Müller; H Richard; Jean Claude Reubi; Markus W Büchler
Study of a primary gastrinoma in the common hepatic duct - a case report.
Digestion 1999;60(2):187-90.
1999: Regula Markwalder; Jean Claude Reubi
Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation.
Cancer research 1999;59(5):1152-9.
1999: B Denzler; Jean Claude Reubi
Expression of somatostatin receptors in peritumoral veins of human tumors.
Cancer 1999;85(1):188-98.
1999: Jean-Claude Schaer; Jean Claude Reubi
High gastrin and cholecystokinin (CCK) gene expression in human neuronal, renal, and myogenic stem cell tumors: comparison with CCK-A and CCK-B receptor contents.
The Journal of clinical endocrinology and metabolism 1999;84(1):233-9.
1998: Jean Claude Reubi; Andreas Kappeler; Beatrice Waser; Agnes Schonbrunn; Jean A Laissue
Immunohistochemical localization of somatostatin receptor sst2A in human pancreatic islets.
The Journal of clinical endocrinology and metabolism 1998;83(10):3746-9.
1998: Jean Claude Reubi; Andreas Kappeler; Beatrice Waser; Jean A Laissue; R William Hipkin; Agnes Schonbrunn
Immunohistochemical localization of somatostatin receptors sst2A in human tumors.
The American journal of pathology 1998;153(1):233-45.
1998: Jean Claude Reubi; U Horisberger; Andreas Kappeler; Jean A Laissue
Localization of receptors for vasoactive intestinal peptide, somatostatin, and substance P in distinct compartments of human lymphoid organs.
Blood 1998;92(1):191-7.
1998: Jean Claude Reubi; Beatrice Waser; Jean-Claude Schaer; U Laederach; Jack Erion; Ananth Srinivasan; Michelle A Schmidt; Joseph E Bugaj
Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo.
European journal of nuclear medicine 1998;25(5):481-90.
1998: Jean Claude Reubi; Beatrice Waser; Helmut Friess; Markus W Büchler; Jean A Laissue
Neurotensin receptors: a new marker for human ductal pancreatic adenocarcinoma.
Gut 1998;42(4):546-50.
1998: Jean Claude Reubi; Jean-Claude Schaer; Beatrice Waser; Carl A Hoeger; Jean Rivier
A selective analog for the somatostatin sst1-receptor subtype expressed by human tumors.
European journal of pharmacology 1998;345(1):103-10.
1997: Jean Claude Reubi; Jean-Claude Schaer; Regula Markwalder; Beatrice Waser; U Horisberger; Jean A Laissue
Distribution of somatostatin receptors in normal and neoplastic human tissues: recent advances and potential relevance.
The Yale journal of biology and medicine 1997;70(5-6):471-9.
1997: M Altschul; kenneth simpson; Nathan L Dykes; E A Mauldin; Jean Claude Reubi; JF Cummings
Evaluation of somatostatin analogues for the detection and treatment of gastrinoma in a dog.
The Journal of small animal practice 1997;38(7):286-91.
1997: Jean Claude Reubi
Regulatory peptide receptors as molecular targets for cancer diagnosis and therapy.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 1997;41(2):63-70.
1997: Jean Claude Reubi; Jean-Claude Schaer; Beatrice Waser
Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors.
Cancer research 1997;57(7):1377-86.
1997: Jean Claude Reubi; Beatrice Waser; U Läderach; Christoph Stettler; Helmut Friess; Fred Halter; Adrian Schmassmann
Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the human stomach.
Gastroenterology 1997;112(4):1197-205.
1997: Jean-Claude Schaer; Beatrice Waser; G Mengod; Jean Claude Reubi
Somatostatin receptor subtypes sst1, sst2, sst3 and sst5 expression in human pituitary, gastroentero-pancreatic and mammary tumors: comparison of mRNA analysis with receptor autoradiography.
International journal of cancer. Journal international du cancer 1997;70(5):530-7.
1997: C A Maurer; C Glaser; Jean Claude Reubi; Markus W Büchler
Carcinoid of the pancreas.
Digestion 1997;58(4):410-4.
1996: Jean Claude Reubi
In vitro identification of VIP receptors in human tumors: potential clinical implications.
Annals of the New York Academy of Sciences 1996;805():753-9.
1996: Jean Claude Reubi; Beatrice Waser
Unexpected high incidence of cholecystokinin-B/gastrin receptors in human medullary thyroid carcinomas.
International journal of cancer. Journal international du cancer 1996;67(5):644-7.
1996: Jean Claude Reubi; Jean-Claude Schaer; Jean A Laissue; Beatrice Waser
Somatostatin receptors and their subtypes in human tumors and in peritumoral vessels.
Metabolism: clinical and experimental 1996;45(8 Suppl 1):39-41.
1996: Jean Claude Reubi; Luca Mazzucchelli; I Hennig; Jean A Laissue
Local up-regulation of neuropeptide receptors in host blood vessels around human colorectal cancers.
Gastroenterology 1996;110(6):1719-26.
1996: Christoph A Maurer; Hans U Baer; T H Dyong; E Mueller-Garamvoelgyi; Helmut Friess; C Ruchti; Jean Claude Reubi; Markus W Büchler
Carcinoid of the pancreas: clinical characteristics and morphological features.
European journal of cancer (Oxford, England : 1990) 1996;32A(7):1109-16.
1996: Jean Claude Reubi; Beatrice Waser; Jean A Laissue; J O Gebbers
Somatostatin and vasoactive intestinal peptide receptors in human mesenchymal tumors: in vitro identification.
Cancer research 1996;56(8):1922-31.
1996: A Barth; A R Haldemann; Jean Claude Reubi; N Godoy; Helmuth Rösler; J A Kinser; Rolf W Seiler
Noninvasive differentiation of meningiomas from other brain tumours using combined 111Indium-octreotide/99mtechnetium-DTPA brain scintigraphy.
Acta neurochirurgica 1996;138(10):1179-85.
1996: M John; Wolfgang Meyerhof; D Richter; Beatrice Waser; Jean-Claude Schaer; Hans Scherübl; J Boese-Landgraf; Peter Neuhaus; C Ziske; K Mölling; Ernst-Otto Riecken; Jean Claude Reubi; Bertram Wiedenmann
Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2.
Gut 1996;38(1):33-9.
1995: Jean Claude Reubi
In vitro identification of vasoactive intestinal peptide receptors in human tumors: implications for tumor imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(10):1846-53.
1995: Jean Claude Reubi
Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(10):1825-35.
1995: Jean Claude Reubi; Beatrice Waser; Jean-Claude Schaer; Regula Markwalder
Somatostatin receptors in human prostate and prostate cancer.
The Journal of clinical endocrinology and metabolism 1995;80(9):2806-14.
1995: I M Hennig; Jean A Laissue; U Horisberger; Jean Claude Reubi
Substance-P receptors in human primary neoplasms: tumoral and vascular localization.
International journal of cancer. Journal international du cancer 1995;61(6):786-92.
1995: A R Haldemann; Helmuth Rösler; A Barth; B Waser; L Geiger; N Godoy; Regula Markwalder; Rolf W Seiler; M Sulzer; Jean Claude Reubi
Somatostatin receptor scintigraphy in central nervous system tumors: role of blood-brain barrier permeability.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(3):403-10.
1995: Jean Claude Reubi; Jean A Laissue
Multiple actions of somatostatin in neoplastic disease.
Trends in pharmacological sciences 1995;16(3):110-5.
1995: Jean Claude Reubi; S J Lamberts; E P Krenning
Receptor imaging of human diseases using radiolabeled peptides.
Journal of receptor and signal transduction research 1995;15(1-4):379-92.
1994: Jean Claude Reubi; Beatrice Waser; H M Markusse; E P Krenning; M VanHagen; Jean A Laissue
Vascular somatostatin receptors in synovium from patients with rheumatoid arthritis.
European journal of pharmacology 1994;271(2-3):371-8.
1994: Jean Claude Reubi
Clinical relevance of somatostatin receptor imaging.
European journal of endocrinology / European Federation of Endocrine Societies 1994;131(6):575-6.
1994: Jean Claude Reubi; Jean A Laissue; Beatrice Waser; U Horisberger; Jean-Claude Schaer
Expression of somatostatin receptors in normal, inflamed, and neoplastic human gastrointestinal tissues.
Annals of the New York Academy of Sciences 1994;733():122-37.
1994: Jean Claude Reubi; Beatrice Waser; Adrian Schmassmann; Fred Halter
Persistent lack of somatostatin receptors in gastric mucosa of healing ulcers in rats.
Gastroenterology 1994;107(2):339-46.
1994: Jean Claude Reubi; Jean-Claude Schaer; Beatrice Waser; G Mengod
Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization.
Cancer research 1994;54(13):3455-9.
1994: Jean Claude Reubi; Luca Mazzucchelli; Jean A Laissue
Intestinal vessels express a high density of somatostatin receptors in human inflammatory bowel disease.
Gastroenterology 1994;106(4):951-9.
1994: Jean Claude Reubi; U Horisberger; Jean A Laissue
High density of somatostatin receptors in veins surrounding human cancer tissue: role in tumor-host interaction?
International journal of cancer. Journal international du cancer 1994;56(5):681-8.
1993: Jean Claude Reubi
The role of peptides and their receptors as tumor markers.
Endocrinology and metabolism clinics of North America 1993;22(4):917-39.
1993: Jean Claude Reubi; U Horisberger; U E Studer; Beatrice Waser; Jean A Laissue
Human kidney as target for somatostatin: high affinity receptors in tubules and vasa recta.
The Journal of clinical endocrinology and metabolism 1993;77(5):1323-8.
1993: Jean Claude Reubi; Beatrice Waser; U Horisberger; E Krenning; Steven W J Lamberts; J O Gebbers; P Gersbach; Jean A Laissue
In vitro autoradiographic and in vivo scintigraphic localization of somatostatin receptors in human lymphatic tissue.
Blood 1993;82(7):2143-51.
1993: Jean A Laissue; B B Chappuis; C Müller; Jean Claude Reubi; J O Gebbers
The intestinal immune system and its relation to disease.
Digestive diseases (Basel, Switzerland) 1993;11(4-5):298-312.
1993: Jean Claude Reubi; Beatrice Waser; Steven W J Lamberts; G Mengod
Somatostatin (SRIH) messenger ribonucleic acid expression in human neuroendocrine and brain tumors using in situ hybridization histochemistry: comparison with SRIH receptor content.
The Journal of clinical endocrinology and metabolism 1993;76(3):642-7.
1992: Jean Claude Reubi; U Horisberger; Beatrice Waser; J O Gebbers; Jean A Laissue
Preferential location of somatostatin receptors in germinal centers of human gut lymphoid tissue.
Gastroenterology 1992;103(4):1207-14.
1992: Jean Claude Reubi
Somatostatin receptors in the gastrointestinal tract in health and disease.
The Yale journal of biology and medicine 1992;65(5):493-503; discussion 531-6.
1992: Jean Claude Reubi; Beatrice Waser; U Horisberger; F Halter; Carol J Soroka; R R Kumar; James R Goldenring; Irvin M Modlin
Identification of somatostatin and gastrin receptors on enterochromaffin-like cells from Mastomys gastric tumors.
Endocrinology 1992;131(1):166-72.
1992: Jean Claude Reubi; Beatrice Waser; M van Hagen; Steven W J Lamberts; E P Krenning; J O Gebbers; Jean Laissue
In vitro and in vivo detection of somatostatin receptors in human malignant lymphomas.
International journal of cancer. Journal international du cancer 1992;50(6):895-900.
1991: T W Huisman; H L Tanghe; Jan W Koper; Jean Claude Reubi; J A Foekens; Cees J J Avezaat; R Braakman; Steven W J Lamberts
Progesterone, oestradiol, somatostatin and epidermal growth factor receptors on human meningiomas and their CT characteristics.
European journal of cancer (Oxford, England : 1990) 1991;27(11):1453-7.
1990: Jean Claude Reubi; E Krenning; Steven W J Lamberts; L Kvols
Somatostatin receptors in malignant tissues.
The Journal of steroid biochemistry and molecular biology 1990;37(6):1073-7.
1990: Jean Claude Reubi; L Kvols; E Krenning; Steven W J Lamberts
Distribution of somatostatin receptors in normal and tumor tissue.
Metabolism: clinical and experimental 1990;39(9 Suppl 2):78-81.
1990: Jean Claude Reubi; T Hunziker
Absence of somatostatin receptors in psoriatic skin lesions.
Archives of dermatological research 1990;282(2):139-41.
1989: Jean Claude Reubi; J Torhorst
The relationship between somatostatin, epidermal growth factor, and steroid hormone receptors in breast cancer.
Cancer 1989;64(6):1254-60.
1989: Jean Claude Reubi; A M Landolt
The growth hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptor status.
The Journal of clinical endocrinology and metabolism 1989;68(4):844-50.
1989: Jean Claude Reubi; U Horisberger; W Lang; J W Koper; R Braakman; Steven W J Lamberts
Coincidence of EGF receptors and somatostatin receptors in meningiomas but inverse, differentiation-dependent relationship in glial tumors.
The American journal of pathology 1989;134(2):337-44.
1988: Jean Claude Reubi; Steven W J Lamberts; R Maurer
Somatostatin receptors in normal and tumoral tissue.
Hormone research 1988;29(2-3):65-9.
1987: Jean Claude Reubi; W Lang; R Maurer; J W Koper; Steven W J Lamberts
Distribution and biochemical characterization of somatostatin receptors in tumors of the human central nervous system.
Cancer research 1987;47(21):5758-64.