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Johannes Reul
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51
Holsboer, Florian
31
Linthorst, Astrid
16
Droste, Susanne
10
Wiegers, Jan
8
Flachskamm, Cornelia
7
Arzt, Eduardo
7
Labeur, Marta
6
Landgraf, Rainer
6
Bilang-Bleuel, Alicia
6
Gesing, Angela
6
Chandramohan, Yalini
5
Müller, Marianne
5
Peñalva, Rosana
5
Rupprecht, Rainer
5
Stalla, Günter
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All Publications
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2009: Droste Susanne K; Collins Andrew; Lightman Stafford L; Linthorst Astrid C E; Reul Johannes M H M
Distinct, time-dependent effects of voluntary exercise on circadian and ultradian rhythms and stress responses of free corticosterone in the rat hippocampus.
Endocrinology 2009;150(9):4170-9.
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2009: Droste S K; de Groote L; Lightman S L; Reul J M H M; Linthorst A C E
The ultradian and circadian rhythms of free corticosterone in the brain are not affected by gender: an in vivo microdialysis study in Wistar rats.
Journal of neuroendocrinology 2009;21(2):132-40.
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2009: Collins Andrew; Hill Louise E; Chandramohan Yalini; Whitcomb Daniel; Droste Susanne K; Reul Johannes M H M
Exercise improves cognitive responses to psychological stress through enhancement of epigenetic mechanisms and gene expression in the dentate gyrus.
PloS one 2009;4(1):e4330.
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2008: Droste Susanne K; de Groote Lotte; Atkinson Helen C; Lightman Stafford L; Reul Johannes M H M; Linthorst Astrid C E
Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress.
Endocrinology 2008;149(7):3244-53.
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2008: Chandramohan Yalini; Droste Susanne K; Arthur J Simon C; Reul Johannes M H M
The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stress-activated kinase signalling pathway.
The European journal of neuroscience 2008;27(10):2701-13.
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2008: Linthorst Astrid C E; Flachskamm Cornelia; Reul Johannes M H M
Water temperature determines neurochemical and behavioural responses to forced swim stress: an in vivo microdialysis and biotelemetry study in rats.
Stress (Amsterdam, Netherlands) 2008;11(2):88-100.
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2007: Reul Johannes M H M; Chandramohan Yalini
Epigenetic mechanisms in stress-related memory formation.
Psychoneuroendocrinology 2007;32 Suppl 1():S21-5.
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2007: Heesen C; Gold S M; Huitinga I; Reul J M H M
Stress and hypothalamic-pituitary-adrenal axis function in experimental autoimmune encephalomyelitis and multiple sclerosis - a review.
Psychoneuroendocrinology 2007;32(6):604-18.
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2007: Chandramohan Yalini; Droste Susanne K; Reul Johannes M H M
Novelty stress induces phospho-acetylation of histone H3 in rat dentate gyrus granule neurons through coincident signalling via the N-methyl-D-aspartate receptor and the glucocorticoid receptor: relevance for c-fos induction.
Journal of neurochemistry 2007;101(3):815-28.
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2007: Droste Susanne K; Chandramohan Yalini; Hill Louise E; Linthorst Astrid C E; Reul Johannes M H M
Voluntary exercise impacts on the rat hypothalamic-pituitary-adrenocortical axis mainly at the adrenal level.
Neuroendocrinology 2007;86(1):26-37.
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2006: Droste S K; Schweizer M C; Ulbricht S; Reul J M H M
Long-term voluntary exercise and the mouse hypothalamic-pituitary-adrenocortical axis: impact of concurrent treatment with the antidepressant drug tianeptine.
Journal of neuroendocrinology 2006;18(12):915-25.
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2005: Basterfield Laura; Reul Johannes M H M; Mathers John C
Impact of physical activity on intestinal cancer development in mice.
The Journal of nutrition 2005;135(12 Suppl):3002S-3008S.
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2005: Bilang-Bleuel Alicia; Ulbricht Sabine; Chandramohan Yalini; De Carli Sonja; Droste Susanne K; Reul Johannes M H M
Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptor-dependent behavioural response.
The European journal of neuroscience 2005;22(7):1691-700.
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2005: de Groote Lotte; Peñalva Rosana G; Flachskamm Cornelia; Reul Johannes M H M; Linthorst Astrid C E
Differential monoaminergic, neuroendocrine and behavioural responses after central administration of corticotropin-releasing factor receptor type 1 and type 2 agonists.
Journal of neurochemistry 2005;94(1):45-56.
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2005: Refojo Damián; Echenique Carlos; Müller Marianne B; Reul Johannes M H M; Deussing Jan M; Wurst Wolfgang; Sillaber Inge; Paez-Pereda Marcelo; Holsboer Florian; Arzt Eduardo
Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6183-8.
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2005: Bachmann Cornelius G; Bilang-Bleuel Alicia; De Carli Sonja; Linthorst Astrid C E; Reul Johannes M H M
The selective glucocorticoid receptor antagonist ORG 34116 decreases immobility time in the forced swim test and affects cAMP-responsive element-binding protein phosphorylation in rat brain.
Neuroendocrinology 2005;81(2):129-36.
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2004: Binder Elke; Droste Susanne K; Ohl Frauke; Reul Johannes M H M
Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in mice.
Behavioural brain research 2004;155(2):197-206.
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2004: Sterzer Philipp; Wiegers G Jan; Reul Johannes M H M
Long-term in vivo administration of glucocorticoid hormones attenuates their capacity to accelerate in vitro proliferation of rat splenic T cells.
Endocrinology 2004;145(8):3630-8.
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2003: Oshima Akihiko; Flachskamm Cornelia; Reul Johannes M H M; Holsboer Florian; Linthorst Astrid C E
Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(12):2148-59.
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2003: Müller Marianne B; Zimmermann Stephan; Sillaber Inge; Hagemeyer Thomas P; Deussing Jan M; Timpl Peter; Kormann Michael S D; Droste Susanne K; Kühn Ralf; Reul Johannes M H M; Holsboer Florian; Wurst Wolfgang
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.
Nature neuroscience 2003;6(10):1100-7.
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2003: Droste Susanne K; Gesing Angela; Ulbricht Sabine; Müller Marianne B; Linthorst Astrid C E; Reul Johannes M H M
Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis.
Endocrinology 2003;144(7):3012-23.
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2003: Bachmann Cornelius G; Linthorst Astrid C E; Holsboer Florian; Reul Johannes M H M
Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(6):1056-67.
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2003: Lancel Marike; Droste Susanne K; Sommer Susanne; Reul Johannes M H M
Influence of regular voluntary exercise on spontaneous and social stress-affected sleep in mice.
The European journal of neuroscience 2003;17(10):2171-9.
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2003: Peñalva Rosana G; Lancel Marike; Flachskamm Cornelia; Reul Johannes M H M; Holsboer Florian; Linthorst Astrid C E
Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats.
The European journal of neuroscience 2003;17(9):1896-906.
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2002: Linthorst Astrid C E; Peñalva Rosana G; Flachskamm Cornelia; Holsboer Florian; Reul Johannes M H M
Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism.
The European journal of neuroscience 2002;16(12):2441-52.
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2002: Refojo Damian; Kovalovsky Damian; Young Juan I; Rubinstein Marcelo; Holsboer Florian; Reul Johannes M H M; Low Malcolm J; Arzt Eduardo
Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice.
Journal of neuroimmunology 2002;131(1-2):126-34.
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2002: Bilang-Bleuel A; Rech J; De Carli S; Holsboer F; Reul J M H M
Forced swimming evokes a biphasic response in CREB phosphorylation in extrahypothalamic limbic and neocortical brain structures in the rat.
The European journal of neuroscience 2002;15(6):1048-60.
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2002: Reul Johannes M H M; Holsboer Florian
Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression.
Current opinion in pharmacology 2002;2(1):23-33.
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2002: Keck Martin E; Wigger Alexandra; Welt Tobias; Müller Marianne B; Gesing Angela; Reul Johannes M H M; Holsboer Florian; Landgraf Rainer; Neumann Inga D
Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(1):94-105.
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2002: Peñalva R G; Flachskamm C; Zimmermann S; Wurst W; Holsboer F; Reul J M H M; Linthorst A C E
Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice.
Neuroscience 2002;109(2):253-66.
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2001: Preil J; Müller M B; Gesing A; Reul J M; Sillaber I; van Gaalen M M; Landgrebe J; Holsboer F; Stenzel-Poore M; Wurst W
Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2.
Endocrinology 2001;142(11):4946-55.
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2001: Stefferl A; Storch M K; Linington C; Stadelmann C; Lassmann H; Pohl T; Holsboer F; Tilders F J; Reul J M
Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone.
Endocrinology 2001;142(8):3616-24.
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2001: Gesing A; Bilang-Bleuel A; Droste S K; Linthorst A C; Holsboer F; Reul J M
Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(13):4822-9.
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2001: Wiegers G J; Stec I E; Klinkert W E; Linthorst A C; Reul J M
Bidirectional effects of corticosterone on splenic T-cell activation: critical role of cell density and culture time.
Neuroendocrinology 2001;73(2):139-48.
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2000: Reul J M; Gesing A; Droste S; Stec I S; Weber A; Bachmann C; Bilang-Bleuel A; Holsboer F; Linthorst A C
The brain mineralocorticoid receptor: greedy for ligand, mysterious in function.
European journal of pharmacology 2000;405(1-3):235-49.
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2000: Wiegers G J; Stec I E; Klinkert W E; Reul J M
Glucocorticoids regulate TCR-induced elevation of CD4: functional implications.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6213-20.
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2000: Hölter S M; Linthorst A C; Reul J M; Spanagel R
Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats.
Pharmacology, biochemistry, and behavior 2000;66(1):143-51.
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2000: Linthorst A C; Flachskamm C; Barden N; Holsboer F; Reul J M
Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice.
The European journal of neuroscience 2000;12(1):283-91.
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2000: Arzt E; Kovalovsky D; Igaz L M; Costas M; Plazas P; Refojo D; Páez-Pereda M; Reul J M; Stalla G; Holsboer F
Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action.
Annals of the New York Academy of Sciences 2000;917():672-7.
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2000: Reul J M; Bilang-Bleuel A; Droste S; Linthorst A C; Holsboer F; Gesing A
New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders.
Zeitschrift für Rheumatologie 2000;59 Suppl 2():II/22-5.
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1999: Stefferl A; Linington C; Holsboer F; Reul J M
Susceptibility and resistance to experimental allergic encephalomyelitis: relationship with hypothalamic-pituitary-adrenocortical axis responsiveness in the rat.
Endocrinology 1999;140(11):4932-8.
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1999: Perez Castro C; Peñalva R; Páez Pereda M; Renner U; Reul J M; Stalla G K; Holsboer F; Arzt E
Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response.
Endocrinology 1999;140(2):690-7.
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1999: Linthorst A C; Reul J M
Inflammation and brain function under basal conditions and during long-term elevation of brain corticotropin-releasing hormone levels.
Advances in experimental medicine and biology 1999;461():129-52.
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1998: Engelmann M; Landgraf R; Lörscher P; Conzelmann C; Probst J C; Holsboer F; Reul J M
Downregulation of brain mineralocorticoid and glucocorticoid receptor by antisense oligodeoxynucleotide treatment fails to alter spatial navigation in rats.
European journal of pharmacology 1998;361(1):17-26.
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1998: Liebsch G; Linthorst A C; Neumann I D; Reul J M; Holsboer F; Landgraf R
Behavioral, physiological, and neuroendocrine stress responses and differential sensitivity to diazepam in two Wistar rat lines selectively bred for high- and low-anxiety-related behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(5):381-96.
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1998: Wiegers G J; Reul J M
Induction of cytokine receptors by glucocorticoids: functional and pathological significance.
Trends in pharmacological sciences 1998;19(8):317-21.
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1998: Timpl P; Spanagel R; Sillaber I; Kresse A; Reul J M; Stalla G K; Blanquet V; Steckler T; Holsboer F; Wurst W
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.
Nature genetics 1998;19(2):162-6.
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1998: Reul J M; Labeur M S; Wiegers G J; Linthorst A C
Altered neuroimmunoendocrine communication during a condition of chronically increased brain corticotropin-releasing hormone drive.
Annals of the New York Academy of Sciences 1998;840():444-55.
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1998: Linthorst A C; Reul J M
Brain neurotransmission during peripheral inflammation.
Annals of the New York Academy of Sciences 1998;840():139-52.
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1998: Dijkstra I; Tilders F J; Aguilera G; Kiss A; Rabadan-Diehl C; Barden N; Karanth S; Holsboer F; Reul J M
Reduced activity of hypothalamic corticotropin-releasing hormone neurons in transgenic mice with impaired glucocorticoid receptor function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(10):3909-18.
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1998: Pauli S; Linthorst A C; Reul J M
Tumour necrosis factor-alpha and interleukin-2 differentially affect hippocampal serotonergic neurotransmission, behavioural activity, body temperature and hypothalamic-pituitary-adrenocortical axis activity in the rat.
The European journal of neuroscience 1998;10(3):868-78.
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1997: Barden N; Stec I S; Montkowski A; Holsboer F; Reul J M
Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor.
Neuroendocrinology 1997;66(3):212-20.
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1997: Karanth S; Linthorst A C; Stalla G K; Barden N; Holsboer F; Reul J M
Hypothalamic-pituitary-adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function.
Endocrinology 1997;138(8):3476-85.
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1997: Schöbitz B; Pezeshki G; Probst J C; Reul J M; Skutella T; Stöhr T; Holsboer F; Spanagel R
Centrally administered oligodeoxynucleotides in rats: occurrence of non-specific effects.
European journal of pharmacology 1997;331(2-3):97-107.
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1997: Linthorst A C; Flachskamm C; Hopkins S J; Hoadley M E; Labeur M S; Holsboer F; Reul J M
Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral, and cytokine responses to a systemic inflammatory challenge.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(11):4448-60.
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1997: Reul J M; Probst J C; Skutella T; Hirschmann M; Stec I S; Montkowski A; Landgraf R; Holsboer F
Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides.
Neuroendocrinology 1997;65(3):189-99.
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1996: Hatzinger M; Reul J M; Landgraf R; Holsboer F; Neumann I
Combined dexamethasone/CRH test in rats: hypothalamo-pituitary-adrenocortical system alterations in aging.
Neuroendocrinology 1996;64(5):349-56.
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1996: Pezeshki G; Schöbitz B; Pohl T; Reul J M
Intracerebroventricular administration of missense oligodeoxynucleotide induces interleukin-6 mRNA expression in brain and spleen of rats.
Neuroscience letters 1996;217(2-3):97-100.
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1996: Costas M; Trapp T; Pereda M P; Sauer J; Rupprecht R; Nahmod V E; Reul J M; Holsboer F; Arzt E
Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis.
The Journal of clinical investigation 1996;98(6):1409-16.
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1996: Linthorst A C; Flachskamm C; Holsboer F; Reul J M
Activation of serotonergic and noradrenergic neurotransmission in the rat hippocampus after peripheral administration of bacterial endotoxin: involvement of the cyclo-oxygenase pathway.
Neuroscience 1996;72(4):989-97.
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1996: Rupprecht R; Berning B; Hauser C A; Holsboer F; Reul J M
Steroid receptor-mediated effects of neuroactive steroids: characterization of structure-activity relationship.
European journal of pharmacology 1996;303(3):227-34.
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1995: Linthorst A C; Flachskamm C; Holsboer F; Reul J M
Intraperitoneal administration of bacterial endotoxin enhances noradrenergic neurotransmission in the rat preoptic area: relationship with body temperature and hypothalamic--pituitary--adrenocortical axis activity.
The European journal of neuroscience 1995;7(12):2418-30.
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1995: Montkowski A; Barden N; Wotjak C; Stec I; Ganster J; Meaney M; Engelmann M; Reul J M; Landgraf R; Holsboer F
Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function.
Journal of neuroendocrinology 1995;7(11):841-5.
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1995: Wiegers G J; Labeur M S; Stec I E; Klinkert W E; Holsboer F; Reul J M
Glucocorticoids accelerate anti-T cell receptor-induced T cell growth.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1893-902.
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1995: Labeur M S; Arzt E; Wiegers G J; Holsboer F; Reul J M
Long-term intracerebroventricular corticotropin-releasing hormone administration induces distinct changes in rat splenocyte activation and cytokine expression.
Endocrinology 1995;136(6):2678-88.
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1995: Schöbitz B; Pezeshki G; Pohl T; Hemmann U; Heinrich P C; Holsboer F; Reul J M
Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(8):659-64.
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1995: Linthorst A C; Flachskamm C; Müller-Preuss P; Holsboer F; Reul J M
Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(4):2920-34.
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1994: Trapp T; Rupprecht R; Castrén M; Reul J M; Holsboer F
Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS.
Neuron 1994;13(6):1457-62.
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1994: Wiegers G J; Reul J M; Holsboer F; de Kloet E R
Enhancement of rat splenic lymphocyte mitogenesis after short term preexposure to corticosteroids in vitro.
Endocrinology 1994;135(6):2351-7.
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1994: Reul J M; Labeur M S; Grigoriadis D E; De Souza E B; Holsboer F
Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide.
Neuroendocrinology 1994;60(5):509-19.
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1994: Linthorst A C; Flachskamm C; Holsboer F; Reul J M
Local administration of recombinant human interleukin-1 beta in the rat hippocampus increases serotonergic neurotransmission, hypothalamic-pituitary-adrenocortical axis activity, and body temperature.
Endocrinology 1994;135(2):520-32.
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1994: Reul J M; Stec I; Wiegers G J; Labeur M S; Linthorst A C; Arzt E; Holsboer F
Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats.
The Journal of clinical investigation 1994;93(6):2600-7.
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1994: Arzt E; Sauer J; Pollmächer T; Labeur M; Holsboer F; Reul J M; Stalla G K
Glucocorticoids suppress interleukin-1 receptor antagonist synthesis following induction by endotoxin.
Endocrinology 1994;134(2):672-7.
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1994: Stec I; Barden N; Reul J M; Holsboer F
Dexamethasone nonsuppression in transgenic mice expressing antisense RNA to the glucocorticoid receptor.
Journal of psychiatric research 1994;28(1):1-5.
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1994: Schöbitz B; Reul J M; Holsboer F
The role of the hypothalamic-pituitary-adrenocortical system during inflammatory conditions.
Critical reviews in neurobiology 1994;8(4):263-91.
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1993: Wiegers G J; Croiset G; Reul J M; Holsboer F; de Kloet E R
Differential effects of corticosteroids on rat peripheral blood T-lymphocyte mitogenesis in vivo and in vitro.
The American journal of physiology 1993;265(6 Pt 1):E825-30.
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1993: Rupprecht R; Reul J M; van Steensel B; Spengler D; Söder M; Berning B; Holsboer F; Damm K
Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.
European journal of pharmacology 1993;247(2):145-54.
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1993: Rupprecht R; Reul J M; Trapp T; van Steensel B; Wetzel C; Damm K; Zieglgänsberger W; Holsboer F
Progesterone receptor-mediated effects of neuroactive steroids.
Neuron 1993;11(3):523-30.
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1993: Reul J M; Stec I; Söder M; Holsboer F
Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system.
Endocrinology 1993;133(1):312-20.
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1993: Rupprecht R; Arriza J L; Spengler D; Reul J M; Evans R M; Holsboer F; Damm K
Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor.
Molecular endocrinology (Baltimore, Md.) 1993;7(4):597-603.
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1992: Reul J M; Söder M; Holsboer F
The hypothalamic-pituitary-adrenocortical (HPA) system and anti-depressive drug (AD) action.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():584A-585A.
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