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Denis Reynaud

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Chemicals & Drugs

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Etienne Pouteau; Olivier Aprikian; Catherine Grenot; Denis Reynaud; Cecil Pace-Asciak; Claude Yves Cuilleron; Eurídice Castañeda-Gutiérrez; Julie Moulin; Gregory Pescia; Carine Beysen; Scott Turner; Katherine Macé
A low alpha-linolenic intake during early life increases adiposity in the adult guinea pig.
Olivier Aprikian; Denis Reynaud; Cecil R Pace-Asciak; Patricia Leone; Florence Blancher; Irina Monnard; Christian Darimont; Katherine Macé
Neonatal dietary supplementation of arachidonic acid increases prostaglandin levels in adipose tissue but does not promote fat mass development in guinea pigs.
Jonathan D Steels; Mathew P Estey; Carol D Froese; Denis Reynaud; Cecil R Pace-Asciak; William S Trimble
Sept12 is a component of the mammalian sperm tail annulus.

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All Publications

2010: Etienne Pouteau; Olivier Aprikian; Catherine Grenot; Denis Reynaud; Cecil Pace-Asciak; Claude Yves Cuilleron; Eurídice Castañeda-Gutiérrez; Julie Moulin; Gregory Pescia; Carine Beysen; Scott Turner; Katherine Macé
A low alpha-linolenic intake during early life increases adiposity in the adult guinea pig.
Nutrition & metabolism 2010;7():8.
2007: Olivier Aprikian; Denis Reynaud; Cecil R Pace-Asciak; Patricia Leone; Florence Blancher; Irina Monnard; Christian Darimont; Katherine Macé
Neonatal dietary supplementation of arachidonic acid increases prostaglandin levels in adipose tissue but does not promote fat mass development in guinea pigs.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(5):R2006-12.
2007: Jonathan D Steels; Mathew P Estey; Carol D Froese; Denis Reynaud; Cecil R Pace-Asciak; William S Trimble
Sept12 is a component of the mammalian sperm tail annulus.
Cell motility and the cytoskeleton 2007;64(10):794-807.
2007: Na Qiao; Denis Reynaud; Mohamed Abdelhaleem; Cecil R Pace-Asciak
Hepoxilin analogs, PBT-3 and PBT-4, cause apoptosis of Gleevec-resistant K562 cells in vitro.
In vivo (Athens, Greece) 2007;21(2):267-71.
2006: Ian B Copland; Denis Reynaud; Cecil R Pace-Asciak; Martin Post
Mechanotransduction of stretch-induced prostanoid release by fetal lung epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2006;291(3):L487-95.
2006: Yi-Wei Huang; Mark C Surka; Denis Reynaud; Cecil R Pace-Asciak; William S Trimble
GTP binding and hydrolysis kinetics of human septin 2.
The FEBS journal 2006;273(14):3248-60.
2006: Julien Hanson; Denis Reynaud; Na Qiao; Philippe Devel; Anne-Lise Moray; Jean-François Renard; Leanne P Kelley; Jean-Yves Winum; Jean-Louis Montero; B Therese Kinsella; Bernard Pirotte; Cecil R Pace-Asciak; Jean-Michel Dogné
Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor.
Journal of medicinal chemistry 2006;49(12):3701-9.
2006: Cecil R Pace-Asciak; Xiang Li; Na Qiao; Denis Reynaud; Peter Demin; Mohamed Abdelhaleem
Hepoxilin analogs, potential new therapeutics in disease.
Current pharmaceutical design 2006;12(8):963-9.
2005: Xiang Li; Na Qiao; Denis Reynaud; Mohamed Abdelhaleem; Cecil R Pace-Asciak
PBT-3, a hepoxilin stable analog, causes long term inhibition of growth of K562 solid tumours in vivo.
Biochemical and biophysical research communications 2005;338(1):158-60.
2005: Julien Hanson; Stéphanie Rolin; Denis Reynaud; Na Qiao; Leanne P Kelley; Helen M Reid; François Valentin; John R Tippins; B Therese Kinsella; Bernard Masereel; Cecil R Pace-Asciak; Bernard Pirotte; Jean-Michel Dogné
In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2005;313(1):293-301.
2005: Xiang Li; Na Qiao; Denis Reynaud; Mohamed Abdelhaleem; Cecil R Pace-Asciak
The hepoxilin analog, PBT-3, inhibits growth of K-562 CML solid tumours in vivo in nude mice.
In vivo (Athens, Greece) 2005;19(1):185-9.
2003: Na Qiao; Denis Reynaud; Peter Demin; Perry V Halushka; Cecil R Pace-Asciak
The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells.
The Journal of pharmacology and experimental therapeutics 2003;307(3):1142-7.
2003: Na Qiao; Janice Lam; Denis Reynaud; Mohamed Abdelhaleem; Cecil R Pace-Asciak
The hepoxilin analog PBT-3 induces apoptosis in BCR-ABL-positive K562 leukemia cells.
Anticancer research 2003;23(5A):3617-22.
2003: Denis Reynaud; Dewi Clark; Na Qiao; Margaret L Rand; Cecil R Pace-Asciak
The hepoxilin stable analogue, PBT-3, inhibits primary, platelet-related hemostasis in whole blood measured in vitro with the PFA-100.
Thrombosis research 2003;112(4):245-8.
2002: Cecil R Pace-Asciak; Denis Reynaud; Peter Demin; Rukshana Aslam; Andrea Sun
A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition.
The Journal of pharmacology and experimental therapeutics 2002;301(2):618-24.
2002: Denis Reynaud; Alexander Hinek; Cecil R Pace-Asciak
The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP.
FEBS letters 2002;515(1-3):58-60.
2001: Denis Reynaud; Andrea Sun; Peter Demin; C R Pac-Asciak
Improved high-performance liquid chromatographic method for the combined analysis of phospholipase, lipoxygenase and cyclooxygenase activities.
Journal of chromatography. B, Biomedical sciences and applications 2001;762(2):175-80.
2001: Denis Reynaud; Andrea Sun; Peter Demin; Cecil R Pace-Asciak
Novel platelet antiaggregating substances.
Biochemical and biophysical research communications 2001;284(3):580-2.
1999: Denis Reynaud; M Ali; Peter Demin; Cecil R Pace-Asciak
Formation of 14,15-hepoxilins of the A(3) and B(3) series through a 15-lipoxygenase and hydroperoxide isomerase present in garlic roots.
The Journal of biological chemistry 1999;274(40):28213-8.
1999: B Rigat; Denis Reynaud; N Smiljanic-Georgijev; Don J Mahuran
The GM2 activator protein, a novel inhibitor of platelet-activating factor.
Biochemical and biophysical research communications 1999;258(2):256-9.
1999: SD Milone; Cecil R Pace-Asciak; Denis Reynaud; Eduardo R Azevedo; Gary E Newton; John D Parker
Biochemical, hemodynamic, and vascular evidence concerning the free radical hypothesis of nitrate tolerance.
Journal of cardiovascular pharmacology 1999;33(5):685-90.
1999: Denis Reynaud; Peter Demin; M Sutherland; S Nigam; Cecil R Pace-Asciak
Hepoxilin signaling in intact human neutrophils: biphasic elevation of intracellular calcium by unesterified hepoxilin A3.
FEBS letters 1999;446(2-3):236-8.
1999: M M Wang; Denis Reynaud; Cecil R Pace-Asciak
In vivo stimulation of 12(S)-lipoxygenase in the rat skin by bradykinin and platelet activating factor: formation of 12(S)-HETE and hepoxilins, and actions on vascular permeability.
Biochimica et biophysica acta 1999;1436(3):354-62.
1999: Cecil R Pace-Asciak; Denis Reynaud; Olga Rounova; Peter Demin; K K Pivnitsky
Hepoxilin A3 is metabolized into its omega-hydroxy metabolite by human neutrophils.
Advances in experimental medicine and biology 1999;469():535-8.
1999: Cecil R Pace-Asciak; Denis Reynaud; Peter Demin; S Nigam
The hepoxilins. A review.
Advances in experimental medicine and biology 1999;447():123-32.
1997: Denis Reynaud; Olga Rounova; Peter Demin; K K Pivnitsky; Cecil R Pace-Asciak
Hepoxilin A3 is oxidized by human neutrophils into its omega-hydroxy metabolite by an activity independent of LTB4 omega-hydroxylase.
Biochimica et biophysica acta 1997;1348(3):287-98.
1997: Denis Reynaud; Cecil R Pace-Asciak
Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates.
Biochimica et biophysica acta 1997;1346(3):305-16.
1997: Linda R Mills; Denis Reynaud; Cecil R Pace-Asciak
Hepoxilin-evoked intracellular reorganization of calcium in human neutrophils: a confocal microscopy study.
Experimental cell research 1997;230(2):337-41.
1997: Cecil R Pace-Asciak; Denis Reynaud; O Laneuville; Sergio Grinstein; S Nigam
Hepoxilin A3 inhibits agonist-evoked rise in free intracellular calcium in human neutrophils.
Advances in experimental medicine and biology 1997;400A():375-80.
1997: Denis Reynaud; Cecil R Pace-Asciak
12-HETE and 12-HPETE potently stimulate intracellular release of calcium in intact human neutrophils.
Prostaglandins, leukotrienes, and essential fatty acids 1997;56(1):9-12.
1996: Denis Reynaud; Peter Demin; Cecil R Pace-Asciak
Hepoxilin A3-specific binding in human neutrophils.
The Biochemical journal 1996;313 ( Pt 2)():537-41.
1996: Peter Demin; Denis Reynaud; Cecil R Pace-Asciak
Chemical synthesis and actions of 11,12-thiirano-hepoxilin A3.
Journal of lipid mediators and cell signalling 1996;13(1):63-72.
1995: Peter Demin; Denis Reynaud; Cecil R Pace-Asciak
High-performance liquid chromatographic separation of fluorescent esters of hepoxilin enantiomers on a chiral stationary phase.
Journal of chromatography. B, Biomedical applications 1995;672(2):282-9.
1995: Cecil R Pace-Asciak; Denis Reynaud; Peter Demin
Mechanistic aspects of hepoxilin biosynthesis.
Journal of lipid mediators and cell signalling 1995;12(2-3):307-11.
1995: Peter Demin; Denis Reynaud; Cecil R Pace-Asciak
Extractive derivatization of the 12-lipoxygenase products, hepoxilins, and related compounds into fluorescent anthryl esters for their complete high-performance liquid chromatography profiling in biological systems.
Analytical biochemistry 1995;226(2):252-5.
1995: Denis Reynaud; Peter Demin; Cecil R Pace-Asciak
Hepoxilin binding in human neutrophils.
Biochemical and biophysical research communications 1995;207(1):191-4.
1995: Cecil R Pace-Asciak; Denis Reynaud; Peter Demin
Hepoxilins: a review on their enzymatic formation, metabolism and chemical synthesis.
Lipids 1995;30(2):107-14.
1995: Denis Reynaud; Peter Demin; Cecil R Pace-Asciak
Enzymatic formation of hepoxilin A3.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():183-5.
1995: Denis Reynaud; Peter Demin; Cecil R Pace-Asciak
Coupling of hepoxilin A3-specific binding with calcium-mobilizing actions in human neutrophils.
Agents and actions. Supplements 1995;45():291-6.
1994: Denis Reynaud; Peter Demin; Cecil R Pace-Asciak
Hepoxilin A3 formation in the rat pineal gland selectively utilizes (12S)-hydroperoxyeicosatetraenoic acid (HPETE), but not (12R)-HPETE.
The Journal of biological chemistry 1994;269(39):23976-80.
1994: Peter Louis Carlen; N Gurevich; L Zhang; P H Wu; Denis Reynaud; Cecil R Pace-Asciak
Formation and electrophysiological actions of the arachidonic acid metabolites, hepoxilins, at nanomolar concentrations in rat hippocampal slices.
Neuroscience 1994;58(3):493-502.
1994: Denis Reynaud; I Delton; Abdallah Gharib; Nicole Sarda; Michel Lagarde; Cecil R Pace-Asciak
Formation, metabolism, and action of hepoxilin A3 in the rat pineal gland.
Journal of neurochemistry 1994;62(1):126-33.
1993: Cecil R Pace-Asciak; Denis Reynaud; Peter Demin
Enzymatic formation of hepoxilins A3 and B3.
Biochemical and biophysical research communications 1993;197(2):869-73.
1993: O Laneuville; Denis Reynaud; Sergio Grinstein; Santosh Nigam; Cecil R Pace-Asciak
Hepoxilin A3 inhibits the rise in free intracellular calcium evoked by formyl-methionyl-leucyl-phenylalanine, platelet-activating factor and leukotriene B4.
The Biochemical journal 1993;295 ( Pt 2)():393-7.
1993: Denis Reynaud; C P Thickitt; Cecil R Pace-Asciak
Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by alpha-tocopherol-directed autoxidation.
Analytical biochemistry 1993;214(1):165-70.
1990: Denis Reynaud; Abdallah Gharib; M Lagarde; Nicole Sarda
Characterization of A-2 receptors in postmortem human pineal gland.
Journal of neurochemistry 1990;55(4):1316-21.
1989: Abdallah Gharib; Denis Reynaud; Nicole Sarda; B Vivien-Roels; Paul Pevet; H Pacheco
Adenosine analogs elevate N-acetylserotonin and melatonin in rat pineal gland.
Neuroscience letters 1989;106(3):345-9.
1989: Nicole Sarda; Abdallah Gharib; Denis Reynaud; L Ou; H Pacheco
Identification of adenosine receptor in rat pineal gland: evidence for A-2 selectivity.
Journal of neurochemistry 1989;53(3):733-7.
1989: Nicole Sarda; Denis Reynaud; Abdallah Gharib
S-adenosylmethionine, S-adenosylhomocysteine and adenosine system. Age-dependent availability in rat brain.
Developmental pharmacology and therapeutics 1989;13(2-4):104-12.
1989: Nicole Sarda; Raymond Cespuglio; Abdallah Gharib; Denis Reynaud
[Role of hypothalamic adenosinergic systems in regulating states of wakefulness in the rat].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1989;308(17):473-8.