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George Ricaurte

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Amy K Goodwin; Melanie Mueller; George A Ricaurte; Courtney D Shell; Nancy A Ator
Behavioral Effects and Pharmacokinetics of ({+/-})-3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) after Intragastric Administration to Baboons.
Melanie Mueller; George Hatzidimitriou; Una D McCann; Jie Yuan; George A Ricaurte
Single oral doses of (±) 3,4-methylenedioxymethamphetamine ('Ecstasy') produce lasting serotonergic deficits in non-human primates: relationship to plasma drug and metabolite concentrations.
Melanie Mueller; Concepcion Maldonado-Adrian; Una D McCann; Jie Yuan; George A Ricaurte
Studies of (±)-3,4-methylenedioxymethamphetamine (MDMA) metabolism and disposition in rats and mice: relationship to neuroprotection and neurotoxicity profile.

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2013: Amy K Goodwin; Melanie Mueller; George A Ricaurte; Courtney D Shell; Nancy A Ator
Behavioral Effects and Pharmacokinetics of ({+/-})-3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) after Intragastric Administration to Baboons.
The Journal of pharmacology and experimental therapeutics 2013;345(3):342-53.
2013: Melanie Mueller; George Hatzidimitriou; Una D McCann; Jie Yuan; George A Ricaurte
Single oral doses of (±) 3,4-methylenedioxymethamphetamine ('Ecstasy') produce lasting serotonergic deficits in non-human primates: relationship to plasma drug and metabolite concentrations.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2013;16(4):791-801.
2013: Melanie Mueller; Concepcion Maldonado-Adrian; Una D McCann; Jie Yuan; George A Ricaurte
Studies of (±)-3,4-methylenedioxymethamphetamine (MDMA) metabolism and disposition in rats and mice: relationship to neuroprotection and neurotoxicity profile.
The Journal of pharmacology and experimental therapeutics 2013;344(2):479-88.
2011: Michael W McLane; Una D McCann; George A Ricaurte
Identifying the serotonin transporter signal in Western blot studies of the neurotoxic potential of MDMA and related drugs.
Synapse (New York, N.Y.) 2011;65(12):1368-72.
2011: Una D McCann; Robert R Edwards; Kristen Kelley; Francis Sgambati; Michael Smith; Michael Wilson; George A Ricaurte
Altered pain responses in abstinent (±)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users.
Psychopharmacology 2011;217(4):475-84.
2011: Melanie Mueller; Concepcion Maldonado Adrian; Una D McCann; Jie Yuan; George A Ricaurte
Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity.
Synapse (New York, N.Y.) 2011;65(10):983-90.
2011: Melanie Mueller; Nancy A Ator; Amy K Goodwin; Una D McCann; George A Ricaurte
Metabolism and disposition of 3,4-methylenedioxymethamphetamine ("ecstasy") in baboons after oral administration: comparison with humans reveals marked differences.
The Journal of pharmacology and experimental therapeutics 2011;338(1):310-7.
2011: Anne Neudörffer; George A Ricaurte; Claire-Marie Martinez; Una D McCann; Annis Mechan; Melanie Mueller; Martine Largeron
Synthesis and neurotoxicity profile of 2,4,5-trihydroxymethamphetamine and its 6-(N-acetylcystein-S-yl) conjugate.
Chemical research in toxicology 2011;24(6):968-78.
2010: Jie Yuan; Martin Darvas; Bethany Sotak; George Hatzidimitriou; Una D McCann; Richard D Palmiter; George A Ricaurte
Dopamine is not essential for the development of methamphetamine-induced neurotoxicity.
Journal of neurochemistry 2010;114(4):1135-42.
2009: Una D McCann; Francis P Sgambati; Alan R Schwartz; George A Ricaurte
Sleep apnea in young abstinent recreational MDMA ("ecstasy") consumers.
Neurology 2009;73(23):2011-7.
2009: Una D McCann; Michael J Wilson; Francis P Sgambati; George A Ricaurte
Sleep deprivation differentially impairs cognitive performance in abstinent methylenedioxymethamphetamine ("Ecstasy") users.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(44):14050-6.
2009: Melanie Mueller; Jie Yuan; Anne Felim; Anne Neudörffer; Frank T Peters; Hans H Maurer; Una D McCann; Martine Largeron; George A Ricaurte
Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(10):2079-86.
2009: Melanie Mueller; Erin A Kolbrich; Frank T Peters; Hans H Maurer; Una D McCann; Marilyn A Huestis; George A Ricaurte
Direct comparison of (+/-) 3,4-methylenedioxymethamphetamine ("ecstasy") disposition and metabolism in squirrel monkeys and humans.
Therapeutic drug monitoring 2009;31(3):367-73.
2009: Melanie Mueller; Erin A Kolbrich-Spargo; Frank T Peters; Marilyn A Huestis; George A Ricaurte; Hans H Maurer
Hydrolysis of 3,4-methylenedioxymethamphetamine (MDMA) metabolite conjugates in human, squirrel monkey, and rat plasma.
Analytical and bioanalytical chemistry 2009;393(6-7):1607-17.
2009: Melanie Mueller; Frank T Peters; Marilyn A Huestis; George A Ricaurte; Hans H Maurer
Simultaneous liquid chromatographic-electrospray ionization mass spectrometric quantification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its metabolites 3,4-dihydroxymethamphetamine, 4-hydroxy-3-methoxymethamphetamine and 3,4-methylenedioxyamphetamine in squirrel monkey and human plasma after acidic conjugate cleavage.
Forensic science international 2009;184(1-3):64-8.
2008: Melanie Mueller; Frank T Peters; George A Ricaurte; Hans H Maurer
Liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxymethamphetamine in rat brain.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;874(1-2):119-24.
2008: Una D McCann; Zsolt Szabo; Melin Vranesic; Michael Palermo; William B Mathews; Hayden T Ravert; Robert F Dannals; George A Ricaurte
Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine ("ecstasy") users: relationship to cognitive performance.
Psychopharmacology 2008;200(3):439-50.
2008: Melanie Mueller; Frank T Peters; Hans H Maurer; Una D McCann; George A Ricaurte
Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its major metabolites in squirrel monkeys at plasma concentrations of MDMA that develop after typical psychoactive doses.
The Journal of pharmacology and experimental therapeutics 2008;327(1):38-44.
2008: Una D McCann; Hiroto Kuwabara; Anil Kumar; Michael Palermo; Rubyna Abbey; James Robert Brasic; Weiguo Ye; Mohab Alexander; Robert F Dannals; Dean F Wong; George A Ricaurte
Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users.
Synapse (New York, N.Y.) 2008;62(2):91-100.
2007: Michael W McLane; George Hatzidimitriou; Jie Yuan; Una D McCann; George A Ricaurte
Heating induces aggregation and decreases detection of serotonin transporter protein on western blots.
Synapse (New York, N.Y.) 2007;61(10):875-6.
2007: Melanie Mueller; Frank T Peters; George A Ricaurte; Hans H Maurer
Validated liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxymethamphetamine in squirrel monkey plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;855(2):262-70.
2007: Una D McCann; Stephen C Peterson; George A Ricaurte
The effect of catecholamine depletion by alpha-methyl-para-tyrosine on measures of cognitive performance and sleep in abstinent MDMA users.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(8):1695-706.
2007: M Luisa Soto Montenegro; Juan José Vaquero; Celso Arango; George A Ricaurte; Pedro García-Barreno; Manuel Desco
Effects of MDMA on blood glucose levels and brain glucose metabolism.
European journal of nuclear medicine and molecular imaging 2007;34(6):916-25.
2007: Una D McCann; Zsolt Szabo; Melin Vranesic; Esen Seckin; Gary S Wand; Anna Duval; Robert F Dannals; George A Ricaurte
Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramine.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2007;9(3):151-7.
2007: Una D McCann; George A Ricaurte
Effects of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) on sleep and circadian rhythms.
TheScientificWorldJournal 2007;7():231-8.
2006: Tao Xie; Liqiong Tong; Michael W McLane; George Hatzidimitriou; Jie Yuan; Una D McCann; George A Ricaurte
Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(12):2639-51.
2006: Jie Yuan; George Hatzidimitriou; Pranav Suthar; Melanie Mueller; Una D McCann; George A Ricaurte
Relationship between temperature, dopaminergic neurotoxicity, and plasma drug concentrations in methamphetamine-treated squirrel monkeys.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1210-8.
2006: Annis Mechan; Jie Yuan; George Hatzidimitriou; Rodney J Irvine; Una D McCann; George A Ricaurte
Pharmacokinetic profile of single and repeated oral doses of MDMA in squirrel monkeys: relationship to lasting effects on brain serotonin neurons.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(2):339-50.
2005: George A Ricaurte; Annis Mechan; Jie Yuan; George Hatzidimitriou; Tao Xie; Andrew Mayne; Una D McCann
Amphetamine treatment similar to that used in the treatment of adult attention-deficit/hyperactivity disorder damages dopaminergic nerve endings in the striatum of adult nonhuman primates.
The Journal of pharmacology and experimental therapeutics 2005;315(1):91-8.
2005: Una D McCann; Zsolt Szabo; Esen Seckin; Peter Rosenblatt; William B Mathews; Hayden T Ravert; Robert F Dannals; George A Ricaurte
Quantitative PET studies of the serotonin transporter in MDMA users and controls using [11C]McN5652 and [11C]DASB.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(9):1741-50.
2005: George A Ricaurte; Una D McCann
Recognition and management of complications of new recreational drug use.
Lancet 2005;365(9477):2137-45.
2004: Tao Xie; Liqiong Tong; Una D McCann; Jie Yuan; Kevin G Becker; Annis Mechan; Chris Cheadle; David M Donovan; George A Ricaurte
Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(32):7043-50.
2004: William E Fantegrossi; William L Woolverton; Michael R Kilbourn; Phillip Sherman; Jie Yuan; George Hatzidimitriou; George A Ricaurte; James H Woods; Gail Winger
Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(7):1270-81.
2004: George A Ricaurte
MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities. Brendon P. Boot, Annis O. Mechan, Una D. McCann, George A. Ricaurte [Eur. J. Pharmacol. 453 (2002) 239-244].
European journal of pharmacology 2004;489(1-2):1.
2004: Una D McCann; George A Ricaurte
Amphetamine neurotoxicity: accomplishments and remaining challenges.
Neuroscience and biobehavioral reviews 2004;27(8):821-6.
2003: George A Ricaurte; Jie Yuan; George Hatzidimitriou; Branden J Cord; Una D McCann
Retraction.
Science (New York, N.Y.) 2003;301(5639):1479.
2003: Levente Kerenyi; George A Ricaurte; David J Schretlen; Una D McCann; Jozsef Varga; William B Mathews; Hayden T Ravert; Robert F Dannals; John Hilton; Dean F Wong; Zsolt Szabo
Positron emission tomography of striatal serotonin transporters in Parkinson disease.
Archives of neurology 2003;60(9):1223-9.
2003: George A Ricaurte; Jie Yuan; George Hatzidimitriou; Branden J Cord; Una D McCann
Response to O'Shea and Colado: the MDMA neurotoxicity profile might provide clues to mechanisms.
Trends in pharmacological sciences 2003;24(6):275.
2002: Michael Taffe; Sophia A Davis; Jie Yuan; Richard Schroeder; George Hatzidimitriou; Loren H Parsons; George A Ricaurte; Lisa H Gold
Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;27(6):993-1005.
2002: Liesbeth Reneman; Jan Booij; Jan B A Habraken; Kora de Bruin; George Hatzidimitriou; Gerard J den Heeten; George A Ricaurte
Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicity.
Synapse (New York, N.Y.) 2002;46(3):199-205.
2002: Jie Yuan; Branden J Cord; Una D McCann; Brian T Callahan; George A Ricaurte
Effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetamines.
The Journal of pharmacology and experimental therapeutics 2002;303(2):831-9.
2002: Brendon P Boot; Annis O Mechan; Una D McCann; George A Ricaurte
MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities.
European journal of pharmacology 2002;453(2-3):239-44.
2002: George A Ricaurte; Jie Yuan; George Hatzidimitriou; Branden J Cord; Una D McCann
Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy").
Science (New York, N.Y.) 2002;297(5590):2260-3.
2002: Julio Bobes; Pilar A Sáiz; MP González; María Teresa Bascarán; Manuel Bousoño; George A Ricaurte; Una D McCann
Use of MDMA and other illicit drugs by young adult males in northern Spain. A five-year study.
European addiction research 2002;8(3):147-54.
2002: Zsolt Szabo; Una D McCann; Alan Wilson; Ursula Scheffel; Taofeek Owonikoko; William B Mathews; Hayden T Ravert; John Hilton; Robert F Dannals; George A Ricaurte
Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditions.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(5):678-92.
2002: George Hatzidimitriou; Elizabeth H Tsai; Una D McCann; George A Ricaurte
Altered prolactin response to M-chlorophenylpiperazine in monkeys previously treated with 3,4-methylenedioxymethamphetamine (MDMA) or fenfluramine.
Synapse (New York, N.Y.) 2002;44(1):51-7.
2002: Jie Yuan; Branden J Cord; Una D McCann; Brian T Callahan; George A Ricaurte
Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicity.
Journal of neurochemistry 2002;80(6):960-9.
2002: Peter J Winsauer; Una D McCann; Jie Yuan; Marcus S Delatte; Michael W Stevenson; George A Ricaurte; Joseph M Moerschbaecher
Effects of fenfluramine, m-CPP and triazolam on repeated-acquisition in squirrel monkeys before and after neurotoxic MDMA administration.
Psychopharmacology 2002;159(4):388-96.
2002: Tao Xie; Liqiong Tong; Tanya Barrett; Jie Yuan; George Hatzidimitriou; Una D McCann; Kevin G Becker; David M Donovan; George A Ricaurte
Changes in gene expression linked to methamphetamine-induced dopaminergic neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(1):274-83.
2001: George A Ricaurte; Una D McCann
Assessing long-term effects of MDMA (Ecstasy).
Lancet 2001;358(9296):1831-2.
2001: Tanya Barrett; Tao Xie; Yulan Piao; Ora Dillon-Carter; George John Kargul; MK Lim; Francis J Chrest; Robert P Wersto; Daniel L Rowley; Magdalena Juhaszova; Li Zhou; Marquis P Vawter; Kevin G Becker; Chris Cheadle; William H Wood; Una D McCann; William J Freed; Minoru S H Ko; George A Ricaurte; David M Donovan
A murine dopamine neuron-specific cDNA library and microarray: increased COX1 expression during methamphetamine neurotoxicity.
Neurobiology of disease 2001;8(5):822-33.
2001: Una D McCann; George A Ricaurte; Mark E Molliver
"Ecstasy" and serotonin neurotoxicity: new findings raise more questions.
Archives of general psychiatry 2001;58(10):907-8.
2001: Brian T Callahan; Branden J Cord; Jie Yuan; Una D McCann; George A Ricaurte
Inhibitors of Na(+)/H(+) and Na(+)/Ca(2+) exchange potentiate methamphetamine-induced dopamine neurotoxicity: possible role of ionic dysregulation in methamphetamine neurotoxicity.
Journal of neurochemistry 2001;77(5):1348-62.
2001: Jie Yuan; Brian T Callahan; Una D McCann; George A Ricaurte
Evidence against an essential role of endogenous brain dopamine in methamphetamine-induced dopaminergic neurotoxicity.
Journal of neurochemistry 2001;77(5):1338-47.
2001: Brian T Callahan; Branden J Cord; George A Ricaurte
Long-term impairment of anterograde axonal transport along fiber projections originating in the rostral raphe nuclei after treatment with fenfluramine or methylenedioxymethamphetamine.
Synapse (New York, N.Y.) 2001;40(2):113-21.
2001: Una D McCann; George A Ricaurte
Caveat emptor: editors beware.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(3):333-6.
2001: George A Ricaurte; Una D McCann
Experimental studies on 3,4-methylenedioxymethamphetamine (MDA, "ecstasy") and its potential to damage brain serotonin neurons.
Neurotoxicity research 2001;3(1):85-99.
2000: Brian T Callahan; Jie Yuan; George A Ricaurte
Fluoxetine increases the anorectic and long-term dopamine-depleting effects of phentermine.
Synapse (New York, N.Y.) 2000;38(4):471-6.
2000: Tao Xie; Una D McCann; S Kim; Jie Yuan; George A Ricaurte
Effect of temperature on dopamine transporter function and intracellular accumulation of methamphetamine: implications for methamphetamine-induced dopaminergic neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(20):7838-45.
2000: S Kim; R Westphalen; Brian T Callahan; George Hatzidimitriou; Jie Yuan; George A Ricaurte
Toward development of an in vitro model of methamphetamine-induced dopamine nerve terminal toxicity.
The Journal of pharmacology and experimental therapeutics 2000;293(2):625-33.
2000: George A Ricaurte; Una D McCann; Zsolt Szabo; Ursula Scheffel
Toxicodynamics and long-term toxicity of the recreational drug, 3, 4-methylenedioxymethamphetamine (MDMA, 'Ecstasy').
Toxicology letters 2000;112-113():143-6.
2000: Una D McCann; V Eligulashvili; George A Ricaurte
(+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: clinical studies.
Neuropsychobiology 2000;42(1):11-6.
2000: George A Ricaurte; Jie Yuan; Una D McCann
(+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals.
Neuropsychobiology 2000;42(1):5-10.
1999: W Ernest Lyons; Laura A Mamounas; George A Ricaurte; Vincenzo Coppola; S W Reid; Susan H Bora; C Wihler; Vassilis E Koliatsos; Lino Tessarollo
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15239-44.
1999: Una D McCann; V Eligulashvili; M Mertl; Dennis L Murphy; George A Ricaurte
Altered neuroendocrine and behavioral responses to m-chlorophenylpiperazine in 3,4-methylenedioxymethamphetamine (MDMA) users.
Psychopharmacology 1999;147(1):56-65.
1999: Zsolt Szabo; Ursula Scheffel; William B Mathews; Hayden T Ravert; KATALINA SZABO; Michael A Kraut; SC Palmon; George A Ricaurte; Robert F Dannals
Kinetic analysis of [11C]McN5652: a serotonin transporter radioligand.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(9):967-81.
1999: George Hatzidimitriou; Una D McCann; George A Ricaurte
Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/-)3,4-methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(12):5096-107.
1999: Una D McCann; M Mertl; V Eligulashvili; George A Ricaurte
Cognitive performance in (+/-) 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users: a controlled study.
Psychopharmacology 1999;143(4):417-25.
1998: Karen I Bolla; Una D McCann; George A Ricaurte
Memory impairment in abstinent MDMA ("Ecstasy") users.
Neurology 1998;51(6):1532-7.
1998: Una D McCann; Jie Yuan; George A Ricaurte
Neurotoxic effects of +/-fenfluramine and phenteramine, alone and in combination, on monoamine neurons in the mouse brain.
Synapse (New York, N.Y.) 1998;30(3):239-46.
1998: Una D McCann; Zsolt Szabo; Ursula Scheffel; Robert F Dannals; George A Ricaurte
Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings.
Lancet 1998;352(9138):1433-7.
1998: Una D McCann; Dean F Wong; Fuji Yokoi; Victor L Villemagne; Robert F Dannals; George A Ricaurte
Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8417-22.
1998: Una D McCann; V Eligulashvili; George A Ricaurte
Adverse neuropsychiatric events associated with dexfenfluramine and fenfluramine.
Progress in neuro-psychopharmacology & biological psychiatry 1998;22(7):1087-102.
1998: Brian T Callahan; George A Ricaurte
Effect of 7-nitroindazole on body temperature and methamphetamine-induced dopamine toxicity.
Neuroreport 1998;9(12):2691-5.
1998: Ursula Scheffel; Zsolt Szabo; William B Mathews; PA Finley; Robert F Dannals; Hayden T Ravert; KATALINA SZABO; Jie Yuan; George A Ricaurte
In vivo detection of short- and long-term MDMA neurotoxicity--a positron emission tomography study in the living baboon brain.
Synapse (New York, N.Y.) 1998;29(2):183-92.
1998: Brian T Callahan; Jie Yuan; G Stover; George Hatzidimitriou; George A Ricaurte
Effects of 2-deoxy-D-glucose on methamphetamine-induced dopamine and serotonin neurotoxicity.
Journal of neurochemistry 1998;70(1):190-7.
1998: Victor L Villemagne; Jie Yuan; Dean F Wong; Robert F Dannals; George Hatzidimitriou; William B Mathews; Hayden T Ravert; John L Musachio; Una D McCann; George A Ricaurte
Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: evidence from [11C]WIN-35,428 positron emission tomography studies and direct in vitro determinations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(1):419-27.
1998: Dean F Wong; George A Ricaurte; Gerhard Gründer; Richard E Rothman; Sakkubai Naidu; Harvey S Singer; James C Harris; Fuji Yokoi; Victor L Villemagne; Sally Szymanski; Albert Gjedde; Michael J Kuhar
Dopamine transporter changes in neuropsychiatric disorders.
Advances in pharmacology (San Diego, Calif.) 1998;42():219-23.
1997: J Fasciano; George Hatzidimitriou; Jie Yuan; J L Katz; George A Ricaurte
N-methylation dissociates methamphetamine's neurotoxic and behavioral pharmacologic effects.
Brain research 1997;771(1):115-20.
1997: Jie Yuan; Una D McCann; George A Ricaurte
Methylphenidate and brain dopamine neurotoxicity.
Brain research 1997;767(1):172-5.
1997: Una D McCann; L S Seiden; Lewis J Rubin; George A Ricaurte
Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence.
JAMA : the journal of the American Medical Association 1997;278(8):666-72.
1997: J Fasciano; T Steele; N Castagnoli; J Katz; George A Ricaurte
The effect of N-methylation on fenfluramine's neurotoxic and pharmacologic actions.
Brain research 1997;763(2):182-90.
1997: Una D McCann; Jie Yuan; George Hatzidimitriou; George A Ricaurte
Selective serotonin reuptake inhibitors dissociate fenfluramine's anorectic and neurotoxic effects: importance of dose, species and drug.
The Journal of pharmacology and experimental therapeutics 1997;281(3):1487-98.
1996: Ursula Scheffel; Zsolt Szabo; William B Mathews; PA Finley; Jie Yuan; B Callahan; George Hatzidimitriou; Robert F Dannals; Hayden T Ravert; George A Ricaurte
Fenfluramine-induced loss of serotonin transporters in baboon brain visualized with PET.
Synapse (New York, N.Y.) 1996;24(4):395-8.
1996: M Sparago; J Wlos; Jie Yuan; George Hatzidimitriou; J Tolliver; T A Dal Cason; J Katz; George A Ricaurte
Neurotoxic and pharmacologic studies on enantiomers of the N-methylated analog of cathinone (methcathinone): a new drug of abuse.
The Journal of pharmacology and experimental therapeutics 1996;279(2):1043-52.
1996: Una D McCann; George Hatzidimitriou; George A Ricaurte
Prolactin response to fenfluramine is independent of serotonin release.
European journal of pharmacology 1996;312(2):R1-2.
1996: Una D McCann; S O Slate; George A Ricaurte
Adverse reactions with 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy').
Drug safety : an international journal of medical toxicology and drug experience 1996;15(2):107-15.
1996: P G Jorens; Luc Heytens; H E Demey; S Andries; George A Ricaurte; Leo Bossaert; P J Schepens
Acute poisoning with amphetamines (MDEA) and heroin: antagonistic effects between the two drugs.
Intensive care medicine 1996;22(5):456-9.
1995: Una D McCann; Jie Yuan; George A Ricaurte
Fenfluramine's appetite suppression and serotonin neurotoxicity are separable.
European journal of pharmacology 1995;283(1-3):R5-7.
1995: Zsolt Szabo; Ursula Scheffel; M Suehiro; Robert F Dannals; Sang Eun Kim; Hayden T Ravert; George A Ricaurte; Henry N Wagner
Positron emission tomography of 5-HT transporter sites in the baboon brain with [11C]McN5652.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1995;15(5):798-805.
1995: C Fischer; George Hatzidimitriou; J Wlos; J Katz; George A Ricaurte
Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(8):5476-85.
1995: U D McConn; George A Ricaurte
On the neurotoxicity of MDMA and related amphetamine derivatives.
Journal of clinical psychopharmacology 1995;15(4):295-6.
1995: Zsolt Szabo; PF Kao; Ursula Scheffel; M Suehiro; William B Mathews; Hayden T Ravert; John L Musachio; S Marenco; Sang Eun Kim; George A Ricaurte
Positron emission tomography imaging of serotonin transporters in the human brain using [11C](+)McN5652.
Synapse (New York, N.Y.) 1995;20(1):37-43.
1994: M Suehiro; Ursula Scheffel; Hayden T Ravert; George A Ricaurte; George Hatzidimitriou; Robert F Dannals; K P Bøgesø; Henry N Wagner
Highly potent indanamine serotonin uptake blockers as radiotracers for imaging serotonin uptake sites.
Nuclear medicine and biology 1994;21(8):1083-91.
1994: T D Steele; Una D McCann; George A Ricaurte
3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"): pharmacology and toxicology in animals and humans.
Addiction (Abingdon, England) 1994;89(5):539-51.
1994: Una D McCann; George Hatzidimitriou; A Ridenour; C Fischer; Jie Yuan; J Katz; George A Ricaurte
Dexfenfluramine and serotonin neurotoxicity: further preclinical evidence that clinical caution is indicated.
The Journal of pharmacology and experimental therapeutics 1994;269(2):792-8.
1994: Una D McCann; A Ridenour; Y Shaham; George A Ricaurte
Serotonin neurotoxicity after (+/-)3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy"): a controlled study in humans.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1994;10(2):129-38.
1994: U Scheffel; Robert F Dannals; M Suehiro; George A Ricaurte; Frank carroll; Michael J Kuhar; Henry N Wagner
Development of PET/SPECT ligands for the serotonin transporter.
NIDA research monograph 1994;138():111-30.
1993: Dean F Wong; B Yung; Robert F Dannals; ELIAS SHAYA; Hayden T Ravert; C A Chen; B Chan; T Folio; Ursula Scheffel; George A Ricaurte
In vivo imaging of baboon and human dopamine transporters by positron emission tomography using [11C]WIN 35,428.
Synapse (New York, N.Y.) 1993;15(2):130-42.
1993: Richard Allen; Una D McCann; George A Ricaurte
Persistent effects of (+/- )3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on human sleep.
Sleep 1993;16(6):560-4.
1993: George A Ricaurte; Alicja L Markowska; Gary L Wenk; George Hatzidimitriou; J Wlos; D S Olton
3,4-Methylenedioxymethamphetamine, serotonin and memory.
The Journal of pharmacology and experimental therapeutics 1993;266(2):1097-105.
1993: Una D McCann; George A Ricaurte
Reinforcing subjective effects of (+/-) 3,4-methylenedioxymethamphetamine ("ecstasy") may be separable from its neurotoxic actions: clinical evidence.
Journal of clinical psychopharmacology 1993;13(3):214-7.
1993: C R Scanzello; George Hatzidimitriou; A L Martello; J L Katz; George A Ricaurte
Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: observations in rats.
The Journal of pharmacology and experimental therapeutics 1993;264(3):1484-91.
1993: Lewis S Seiden; K E Sabol; George A Ricaurte
Amphetamine: effects on catecholamine systems and behavior.
Annual review of pharmacology and toxicology 1993;33():639-77.
1993: M Suehiro; Ursula Scheffel; Robert F Dannals; Hayden T Ravert; George A Ricaurte; Henry N Wagner
A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(1):120-7.
1993: Una D McCann; George A Ricaurte
Strategies for detecting subclinical monoamine depletions in humans.
NIDA research monograph 1993;136():53-60; discussion 60-2.
1992: Una D McCann; George A Ricaurte
MDMA ("ecstasy") and panic disorder: induction by a single dose.
Biological psychiatry 1992;32(10):950-3.
1992: T D Steele; J L Katz; George A Ricaurte
Evaluation of the neurotoxicity of N-methyl-1-(4-methoxyphenyl)-2-aminopropane (para-methoxymethamphetamine, PMMA).
Brain research 1992;589(2):349-52.
1992: Ursula Scheffel; John R Lever; M Stathis; George A Ricaurte
Repeated administration of MDMA causes transient down-regulation of serotonin 5-HT2 receptors.
Neuropharmacology 1992;31(9):881-93.
1992: Ursula Scheffel; Robert F Dannals; E J Cline; George A Ricaurte; Frank carroll; Philip Abraham; Anita H Lewin; Michael J Kuhar
[123/125I]RTI-55, an in vivo label for the serotonin transporter.
Synapse (New York, N.Y.) 1992;11(2):134-9.
1992: George A Ricaurte; Una D McCann
Neurotoxic amphetamine analogues: effects in monkeys and implications for humans.
Annals of the New York Academy of Sciences 1992;648():371-82.
1992: George A Ricaurte; A L Martello; J L Katz; M B Martello
Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations.
The Journal of pharmacology and experimental therapeutics 1992;261(2):616-22.
1992: ELIAS SHAYA; Ursula Scheffel; Robert F Dannals; George A Ricaurte; Frank carroll; Henry N Wagner; Michael J Kuhar; Dean F Wong
In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine-123 labeled RTI-55.
Synapse (New York, N.Y.) 1992;10(2):169-72.
1992: Jonathan L Katz; George A Ricaurte; Jeffrey M Witkin
Reinforcing effects of enantiomers of N,N-dimethylamphetamine in squirrel monkeys.
Psychopharmacology 1992;107(2-3):315-8.
1992: J H Krystal; L H Price; C Opsahl; George A Ricaurte; G R Heninger
Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and neuropsychological function?
The American journal of drug and alcohol abuse 1992;18(3):331-41.
1992: Z Y Zhao; Neal Castagnoli; George A Ricaurte; T Steele; M Martello
Synthesis and neurotoxicological evaluation of putative metabolites of the serotonergic neurotoxin 2-(methylamino)-1-[3,4-(methylenedioxy)phenyl] propane [(methylenedioxy)methamphetamine].
Chemical research in toxicology 1992;5(1):89-94.
1991: George A Ricaurte; Mark E Molliver; M B Martello; J L Katz; Mary Ann Wilson; A L Martello
Dexfenfluramine neurotoxicity in brains of non-human primates.
Lancet 1991;338(8781):1487-88.
1991: Una D McCann; George A Ricaurte
Lasting neuropsychiatric sequelae of (+-)methylenedioxymethamphetamine ('ecstasy') in recreational users.
Journal of clinical psychopharmacology 1991;11(5):302-5.
1991: W A Dornan; J L Katz; George A Ricaurte
The effects of repeated administration of MDMA on the expression of sexual behavior in the male rat.
Pharmacology, biochemistry, and behavior 1991;39(3):813-6.
1991: Una D McCann; George A Ricaurte
Major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons.
Brain research 1991;545(1-2):279-82.
1990: Ursula Scheffel; George A Ricaurte
Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomography ligand?
Brain research 1990;527(1):89-95.
1990: I S Segal; J K Walton; I Irwin; L E DeLanney; George A Ricaurte; J William Langston; Mervyn Maze
Modulating role of dopamine on anesthetic requirements.
European journal of pharmacology 1990;186(1):9-15.
1990: Jeffrey M Witkin; George A Ricaurte; Jonathan L Katz
Behavioral effects of N-methylamphetamine and N,N-dimethylamphetamine in rats and squirrel monkeys.
The Journal of pharmacology and experimental therapeutics 1990;253(2):466-74.
1990: George A Ricaurte; K T Finnegan; I Irwin; J William Langston
Aminergic metabolites in cerebrospinal fluid of humans previously exposed to MDMA: preliminary observations.
Annals of the New York Academy of Sciences 1990;600():699-708; discussion 708-10.
1989: K T Finnegan; L E DeLanney; I Irwin; George A Ricaurte; J William Langston
The amine-depleting effects of 5,7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age.
Brain research 1989;496(1-2):251-6.
1989: George A Ricaurte; L E DeLanney; I Irwin; J M Witkin; J L Katz; J William Langston
Evaluation of the neurotoxic potential of N,N-dimethylamphetamine: an illicit analog of methamphetamine.
Brain research 1989;490(2):301-6.
1989: William L Woolverton; George A Ricaurte; L S Forno; Lewis S Seiden
Long-term effects of chronic methamphetamine administration in rhesus monkeys.
Brain research 1989;486(1):73-8.
1989: Mary Ann Wilson; George A Ricaurte; Mark E Molliver
Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine.
Neuroscience 1989;28(1):121-37.
1989: L T Simon; George A Ricaurte; L S Forno
Chronic idiopathic ataxic neuropathy: neuropathology of a case.
Acta neuropathologica 1989;79(1):104-7.
1989: Lawrence H Price; George A Ricaurte; John H Krystal; George R Heninger
Responses to i.v. L-tryptophan in MDMA users.
NIDA research monograph 1989;95():421-2.
1989: George A Ricaurte
Studies of MDMA-induced neurotoxicity in nonhuman primates: a basis for evaluating long-term effects in humans.
NIDA research monograph 1989;94():306-22.
1989: Lawrence H Price; George A Ricaurte; John H Krystal; George R Heninger
Neuroendocrine and mood responses to intravenous L-tryptophan in 3,4-methylenedioxymethamphetamine (MDMA) users. Preliminary observations.
Archives of general psychiatry 1989;46(1):20-2.
1988: George A Ricaurte; L E DeLanney; S G Wiener; I Irwin; J William Langston
5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates.
Brain research 1988;474(2):359-63.
1988: George A Ricaurte; L S Forno; Mary Ann Wilson; L E DeLanney; I Irwin; Mark E Molliver; J William Langston
(+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates.
JAMA : the journal of the American Medical Association 1988;260(1):51-5.
1988: K T Finnegan; George A Ricaurte; L D Ritchie; I Irwin; S J Peroutka; J William Langston
Orally administered MDMA causes a long-term depletion of serotonin in rat brain.
Brain research 1988;447(1):141-4.
1988: I Irwin; George A Ricaurte; L E DeLanney; J William Langston
The sensitivity of nigrostriatal dopamine neurons to MPP+ does not increase with age.
Neuroscience letters 1988;87(1-2):51-6.
1988: George A Ricaurte; L E DeLanney; I Irwin; J William Langston
Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration.
Brain research 1988;446(1):165-8.
1988: George A Ricaurte; L E DeLanney; K T Finnegan; I Irwin; J William Langston
The dopamine-depleting effect of 6-hydroxydopamine does not increase with aging.
Brain research 1988;438(1-2):395-8.
1987: K T Finnegan; I Irwin; L E Delanney; George A Ricaurte; J William Langston
1,2,3,6-tetrahydro-1-methyl-4-(methylpyrrol-2-yl)pyridine: studies on the mechanism of action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
The Journal of pharmacology and experimental therapeutics 1987;242(3):1144-51.
1987: S S Wang; George A Ricaurte; S J Peroutka
[3H]3,4-methylenedioxymethamphetamine (MDMA) interactions with brain membranes and glass fiber filter paper.
European journal of pharmacology 1987;138(3):439-43.
1987: George A Ricaurte; K F Finnegan; D E Nichols; L E DeLanney; I Irwin; J William Langston
3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain.
European journal of pharmacology 1987;137(2-3):265-8.
1987: George A Ricaurte; I Irwin; L S Forno; L E DeLanney; E Langston; J William Langston
Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra.
Brain research 1987;403(1):43-51.
1987: George A Ricaurte; L E DeLanney; I Irwin; J William Langston
Older dopaminergic neurons do not recover from the effects of MPTP.
Neuropharmacology 1987;26(1):97-9.
1987: J William Langston; I Irwin; George A Ricaurte
Neurotoxins, parkinsonism and Parkinson's disease.
Pharmacology & therapeutics 1987;32(1):19-49.
1986: L S Forno; J William Langston; L E DeLanney; I Irwin; George A Ricaurte
Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys.
Annals of neurology 1986;20(4):449-55.
1986: S G Waxman; George A Ricaurte; S B Tucker
Thalamic hemorrhage with neglect and memory disorder.
Journal of the neurological sciences 1986;75(1):105-12.
1986: George A Ricaurte; J William Langston; L E Delanney; I Irwin; S J Peroutka; L S Forno
Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: a neurochemical and morphological reassessment.
Brain research 1986;376(1):117-24.
1985: George A Ricaurte; G Bryan; L Strauss; L Seiden; Charles R Schuster
Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals.
Science (New York, N.Y.) 1985;229(4717):986-8.
1985: George A Ricaurte; J William Langston; L E DeLanney; I Irwin; J D Brooks
Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum.
Neuroscience letters 1985;59(3):259-64.
1985: S J Peroutka; L DeLanney; I Irwin; P J Ison; George A Ricaurte; J R Schlegel; J William Langston
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopamine D2 receptor hypersensitivity in the mouse is transient.
Research communications in chemical pathology and pharmacology 1985;48(2):163-71.
1984: George A Ricaurte; L S Seiden; Charles R Schuster
Further evidence that amphetamines produce long-lasting dopamine neurochemical deficits by destroying dopamine nerve fibers.
Brain research 1984;303(2):359-64.
1984: George A Ricaurte; R W Guillery; L S Seiden; Charles R Schuster
Nerve terminal degeneration after a single injection of D-amphetamine in iprindole-treated rats: relation to selective long-lasting dopamine depletion.
Brain research 1984;291(2):378-82.
1983: George A Ricaurte; L S Seiden; Charles R Schuster
Increased dopamine metabolism in the rat neostriatum after toxic doses of d-methylamphetamine.
Neuropharmacology 1983;22(12A):1383-8.
1983: George A Ricaurte; R W Fuller; K W Perry; L S Seiden; Charles R Schuster
Fluoxetine increases long-lasting neostriatal dopamine depletion after administration of d-methamphetamine and d-amphetamine.
Neuropharmacology 1983;22(10):1165-9.
1982: G C Wagner; Kenzie L. Preston; George A Ricaurte; Charles R Schuster; L S Seiden
Neurochemical similarities between d,l-cathinone and d-amphetamine.
Drug and alcohol dependence 1982;9(4):279-84.
1982: George A Ricaurte; R W Guillery; L S Seiden; Charles R Schuster; R Y Moore
Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain.
Brain research 1982;235(1):93-103.
1982: K T Finnegan; George A Ricaurte; L S Seiden; Charles R Schuster
Altered sensitivity to d-methylamphetamine, apomorphine, and haloperidol in rhesus monkeys depleted of caudate dopamine by repeated administration of d-methylamphetamine.
Psychopharmacology 1982;77(1):43-52.
1980: George A Ricaurte; Charles R Schuster; L S Seiden
Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: a regional study.
Brain research 1980;193(1):153-63.
1980: G C Wagner; George A Ricaurte; Chris-Ellyn Johanson; Charles R Schuster; L S Seiden
Amphetamine induces depletion of dopamine and loss of dopamine uptake sites in caudate.
Neurology 1980;30(5):547-50.
1980: G C Wagner; George A Ricaurte; L S Seiden; Charles R Schuster; R J Miller; J Westley
Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine.
Brain research 1980;181(1):151-60.