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Charles Rice

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Joshua A Horwitz; Joana Loureiro; Thomas Oh; Bridget M Donovan; Marcus Dorner; Tamar Friling; Charles M Rice; Alexander Vogt; Alexander Ploss
Expression of heterologous proteins flanked by NS3-4A cleavage sites within the hepatitis C virus polyprotein.
Meigang Gu; Charles M Rice
Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function.
Cynthia de la Fuente; Zachary Goodman; Charles M Rice
Genetic and functional characterization of the N-terminal region of the hepatitis C virus NS2 protein.

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All Publications

2013: Joshua A Horwitz; Joana Loureiro; Thomas Oh; Bridget M Donovan; Marcus Dorner; Tamar Friling; Charles M Rice; Alexander Vogt; Alexander Ploss
Expression of heterologous proteins flanked by NS3-4A cleavage sites within the hepatitis C virus polyprotein.
Virology 2013;439(1):23-33.
2013: Meigang Gu; Charles M Rice
Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function.
Current opinion in virology 2013;3(2):129-36.
2013: Cynthia de la Fuente; Zachary Goodman; Charles M Rice
Genetic and functional characterization of the N-terminal region of the hepatitis C virus NS2 protein.
Journal of virology 2013;87(8):4130-45.
2013: Eui-Cheol Shin; Charles M Rice; Laura Caggiari; Valli De Re; Stephen M Feinstone; Marian Major; Michelina Nascimbeni; Su-Hyung Park; Barbara Rehermann
The frequency of CD127(+) hepatitis C virus (HCV)-specific T cells but not the expression of exhaustion markers predicts the outcome of acute HCV infection.
Journal of virology 2013;87(8):4772-7.
2013: Marcus Dorner; Charles M Rice; Alexander Ploss
Study of hepatitis C virus entry in genetically humanized mice.
Methods (San Diego, Calif.) 2013;59(2):249-57.
2012: Zhigang Yi; Zhenghong Yuan; Charles M Rice; Margaret R MacDonald
Flavivirus replication complex assembly revealed by DNAJC14 functional mapping.
Journal of virology 2012;86(21):11815-32.
2012: Sam J Wilson; Trinity Zang; Mudathir A Alim; Julia Bitzegeio; Nolwenn Jouvenet; Sebla B Kutluay; Charles M Rice; John W Schoggins; Paul D Bieniasz
Inhibition of HIV-1 particle assembly by 2',3'-cyclic-nucleotide 3'-phosphodiesterase.
Cell host & microbe 2012;12(4):585-97.
2012: Mohsan Saeed; Troels K H Scheel; Jens Bukh; Lynn B Dustin; Judith M Gottwein; Svetlana Marukian; Charles M Rice
Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells.
Antimicrobial agents and chemotherapy 2012;56(10):5365-73.
2012: John W Schoggins; Marcus Dorner; Michael Feulner; Naoko Imanaka; Mary Y Murphy; Alexander Ploss; Charles M Rice
Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14610-5.
2012: Terry C Fang; Kevin Lee; Margaret R MacDonald; Ingrid Mecklenbrauker; Valentino Parravicini; Rab Prinjha; Charles M Rice; Inmaculada Rioja; Uwe Schaefer; Astrid Stienen; Rohit Chandwani; Marie S Chen; Scott Dewell; Alexander Tarakhovsky
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response.
The Journal of experimental medicine 2012;209(4):661-9.
2012: Xiangzhi Meng; Alexander Ploss; Charles M Rice; Lloyd Rose; John W Schoggins; Jingxin Cao; Yan Xiang
C7L family of poxvirus host range genes inhibits antiviral activities induced by type I interferons and interferon regulatory factor 1.
Journal of virology 2012;86(8):4538-47.
2012: Sophiya Karki; Melody M H Li; Charles M Rice; John W Schoggins; Suyan Tian; Margaret R MacDonald
Multiple interferon stimulated genes synergize with the zinc finger antiviral protein to mediate anti-alphavirus activity.
PloS one 2012;7(5):e37398.
2011: Christine A Biron; Charles M Rice
Innate immunity: trolling, responding and protecting against viral infections.
Current opinion in virology 2011;1(6):443-6.
2011: John W Schoggins; Charles M Rice
Interferon-stimulated genes and their antiviral effector functions.
Current opinion in virology 2011;1(6):519-25.
2011: Linda Andrus; Walter T Barry; Sangeeta N Bhatia; Maria Teresa Catanese; Lynn B Dustin; Christopher T Jones; Svetlana Marukian; Alexander Ploss; John W Schoggins; Timothy P Sheahan; Kartik Trehan; Charles M Rice
Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells.
Hepatology (Baltimore, Md.) 2011;54(6):1901-12.
2011: Svetlana Marukian; Alexander Ploss; Charles M Rice; Timothy P Sheahan; Linda Andrus; Edgar Charles; Christopher T Jones; Lynn B Dustin
Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures.
Hepatology (Baltimore, Md.) 2011;54(6):1913-23.
2011: Charles M Rice
New insights into HCV replication: potential antiviral targets.
Topics in antiviral medicine 2011;19(3):117-20.
2011: Eui-Cheol Shin; Naga S Veerapu; Charles M Rice; Mary Demino; Stephen M Feinstone; Theo Heller; Marian E Major; Kathleen Mihalik; Michelina Nascimbeni; Su-Hyung Park; Barbara Rehermann
Delayed induction, not impaired recruitment, of specific CD8⁺ T cells causes the late onset of acute hepatitis C.
Gastroenterology 2011;141(2):686-95, 695.e1.
2011: Marcus Dorner; Qian Feng; Joshua A Horwitz; Christopher T Jones; Mansun Law; Kathy Mu; Walter T Barry; Dennis R Burton; Maria Teresa Catanese; Charles M Rice; Justin B Robbins; John W Schoggins; Alexander Ploss
A genetically humanized mouse model for hepatitis C virus infection.
Nature 2011;474(7350):208-11.
2011: Edgar Charles; Claudia Brunetti; Svetlana Marukian; Kimberly D Ritola; Andrew H Talal; Kristen Marks; Ira M Jacobson; Charles M Rice; Lynn B Dustin
Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset.
Blood 2011;117(20):5425-37.
2011: Gisa Gerold; Charles M Rice
Locking out hepatitis C.
Nature medicine 2011;17(5):542-4.
2011: Ype P de Jong; Charles M Rice; Alexander Ploss
Evaluation of combination therapy against hepatitis C virus infection in human liver chimeric mice.
Journal of hepatology 2011;54(5):848-50.
2011: John W Schoggins; Sam J Wilson; Maryline Panis; Mary Y Murphy; Christopher T Jones; Paul D Bieniasz; Charles M Rice
A diverse range of gene products are effectors of the type I interferon antiviral response.
Nature 2011;472(7344):481-5.
2011: Eva Billerbeck; Walter T Barry; Kathy Mu; Marcus Dorner; Charles M Rice; Alexander Ploss
Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rγ(null) humanized mice.
Blood 2011;117(11):3076-86.
2011: Catherine L Murray; Charles M Rice
Turning hepatitis C into a real virus.
Annual review of microbiology 2011;65():307-27.
2011: Zhigang Yi; Lindsey Sperzel; Cindy Nürnberger; Peter J Bredenbeek; Kirk J Lubick; Sonja M Best; Cristina T Stoyanov; Lok-Man J Law; Zhenghong Yuan; Charles M Rice; Margaret R MacDonald
Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator.
PLoS pathogens 2011;7(1):e1001255.
2010: Gisa Gerold; Charles M Rice; Alexander Ploss
Teaching new tricks to an old foe: murinizing hepatitis C virus.
Hepatology (Baltimore, Md.) 2010;52(6):2233-6.
2010: David Franco; Wenjing Li; Fang Qing; Cristina T Stoyanov; Thomas Moran; Charles M Rice; David D Ho
Evaluation of yellow fever virus 17D strain as a new vector for HIV-1 vaccine development.
Vaccine 2010;28(35):5676-85.
2010: Indu kohaar; Alexander Ploss; Evgenia Korol; Kathy Mu; John W Schoggins; Thomas R O'Brien; Charles M Rice; Ludmila Prokunina-Olsson
Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry.
Journal of virology 2010;84(14):6987-94.
2010: Ileana M Cristea; Heather Rozjabek; Kelly R Molloy; Sophiya Karki; Laura L White; Charles M Rice; Michael P Rout; Brian T Chait; Margaret R MacDonald
Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication.
Journal of virology 2010;84(13):6720-32.
2010: Cristina T Stoyanov; Silvia B Boscardin; Stephanie Deroubaix; Giovanna Barba-Spaeth; David Franco; Ruth S Nussenzweig; Michel Nussenzweig; Charles M Rice
Immunogenicity and protective efficacy of a recombinant yellow fever vaccine against the murine malarial parasite Plasmodium yoelii.
Vaccine 2010;28(29):4644-52.
2010: Margaret A Scull; Charles M Rice
A big role for small RNAs in influenza virus replication.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11153-4.
2010: Zhilei Chen; Rudo L Simeon; Karuppiah Chockalingam; Charles M Rice
Creation and characterization of a cell-death reporter cell line for hepatitis C virus infection.
Antiviral research 2010;86(2):220-3.
2010: Lok-Man J Law; Owen R Albin; John-William N Carroll; Christopher T Jones; Charles M Rice; Margaret R MacDonald
Identification of a dominant negative inhibitor of human zinc finger antiviral protein reveals a functional endogenous pool and critical homotypic interactions.
Journal of virology 2010;84(9):4504-12.
2010: Ype P de Jong; Charles M Rice; Alexander Ploss
New horizons for studying human hepatotropic infections.
The Journal of clinical investigation 2010;120(3):650-3.
2010: Alexander Ploss; Salman R Khetani; Christopher T Jones; Andrew J Syder; Kartik Trehan; Valeriya A Gaysinskaya; Kathy Mu; Kimberly Ritola; Charles M Rice; Sangeeta N Bhatia
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3141-5.
2010: Christopher T Jones; Maria Teresa Catanese; Lok-Man J Law; Salman R Khetani; Andrew J Syder; Alexander Ploss; Thomas S Oh; John W Schoggins; Margaret R MacDonald; Sangeeta N Bhatia; Charles M Rice
Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system.
Nature biotechnology 2010;28(2):167-71.
2010: Martina Kopp; Catherine L Murray; Christopher T Jones; Charles M Rice
Genetic analysis of the carboxy-terminal region of the hepatitis C virus core protein.
Journal of virology 2010;84(4):1666-73.
2010: Meigang Gu; Charles M Rice
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):521-8.
2010: Deborah L Diamond; Andrew J Syder; Jon M Jacobs; Christina M Sorensen; Kathie-Anne Walters; Sean C Proll; Jason E McDermott; Marina A Gritsenko; Qibin Zhang; Rui Zhao; Thomas O Metz; David G Camp; Katrina M Waters; Richard D Smith; Charles M Rice; Michael G Katze
Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics.
PLoS pathogens 2010;6(1):e1000719.
2009: Rama S Akondy; Nathan D Monson; Joseph D Miller; Srilatha Edupuganti; Dirk Teuwen; Hong Wu; Farah Quyyumi; Seema Garg; John D Altman; Carlos Del Rio; Harry L Keyserling; Alexander Ploss; Charles M Rice; Walter A Orenstein; Mark MULLIGAN; Rafi Ahmed
The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7919-30.
2009: Thomas G Dentzer; Ivo C Lorenz; Matthew J Evans; Charles M Rice
Determinants of the hepatitis C virus nonstructural protein 2 protease domain required for production of infectious virus.
Journal of virology 2009;83(24):12702-13.
2009: Alexander Ploss; Charles M Rice
Towards a small animal model for hepatitis C.
EMBO reports 2009;10(11):1220-7.
2009: Till Strowig; Cagan Gurer; Alexander Ploss; Yi-Fang Liu; Frida Arrey; Junji Sashihara; Gloria Koo; Charles M Rice; James W Young; Amy Chadburn; Jeffrey I Cohen; Christian Münz
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components.
The Journal of experimental medicine 2009;206(6):1423-34.
2009: Alexander Ploss; Matthew J Evans; Valeriya A Gaysinskaya; Maryline Panis; Hana You; Ype P de Jong; Charles M Rice
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells.
Nature 2009;457(7231):882-6.
2009: Kathie-Anne Walters; Andrew J Syder; Sharon L Lederer; Deborah L Diamond; Bryan Paeper; Charles M Rice; Michael G Katze
Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes.
PLoS pathogens 2009;5(1):e1000269.
2009: Thomas S Oh; Charles M Rice
Predicting response to hepatitis C therapy.
The Journal of clinical investigation 2009;119(1):5-7.
2008: Svetlana Marukian; Christopher T Jones; Linda Andrus; Matthew J Evans; Kimberly D Ritola; Edgar Charles; Charles M Rice; Lynn B Dustin
Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells.
Hepatology (Baltimore, Md.) 2008;48(6):1843-50.
2008: Benno Wölk; Benjamin Büchele; Darius Moradpour; Charles M Rice
A dynamic view of hepatitis C virus replication complexes.
Journal of virology 2008;82(21):10519-31.
2008: Catherine L Murray; Christopher T Jones; Charles M Rice
Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis.
Nature reviews. Microbiology 2008;6(9):699-708.
2008: Donna M Tscherne; Matthew J Evans; Margaret R MacDonald; Charles M Rice
Transdominant inhibition of bovine viral diarrhea virus entry.
Journal of virology 2008;82(5):2427-36.
2008: Thomas von Hahn; Charles M Rice
Hepatitis C virus entry.
The Journal of biological chemistry 2008;283(7):3689-93.
2008: Catherine L Murray; Joseph Marcotrigiano; Charles M Rice
Bovine viral diarrhea virus core is an intrinsically disordered protein that binds RNA.
Journal of virology 2008;82(3):1294-304.
2008: Timothy L Tellinghuisen; Katie L Foss; Jason C Treadaway; Charles M Rice
Identification of residues required for RNA replication in domains II and III of the hepatitis C virus NS5A protein.
Journal of virology 2008;82(3):1073-83.
2008: Edgar Charles; Rashidah M Green; Svetlana Marukian; Andrew H Talal; Gerond V Lake-Bakaar; Ira M Jacobson; Charles M Rice; Lynn B Dustin
Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia.
Blood 2008;111(3):1344-56.
2008: Luke Uebelhoer; Jin-Hwan Han; Benoit Callendret; Guaniri Mateu; Naglaa H Shoukry; Holly L Hanson; Charles M Rice; Christopher M Walker; Arash Grakoui
Stable cytotoxic T cell escape mutation in hepatitis C virus is linked to maintenance of viral fitness.
PLoS pathogens 2008;4(9):e1000143.
2008: Shihyun You; Charles M Rice
3' RNA elements in hepatitis C virus replication: kissing partners and long poly(U).
Journal of virology 2008;82(1):184-95.
2007: Eui-Cheol Shin; Ulrike Seifert; Sabrina Urban; Kim-Thuy Truong; Stephen M Feinstone; Charles M Rice; Peter-M Kloetzel; Barbara Rehermann
Proteasome activator and antigen-processing aminopeptidases are regulated by virus-induced type I interferon in the hepatitis C virus-infected liver.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(12):985-90.
2007: Zania Stamataki; Stephen R Coates; Matthew J Evans; Mark Wininger; Kevin Crawford; Christine Dong; Yiu-Lian Fong; David Chien; Sergio Abrignani; Peter Balfe; Charles M Rice; Jane A McKeating; Michael Houghton
Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies.
Vaccine 2007;25(45):7773-84.
2007: Jérémie Decalf; Sandrine Fernandes; Randy S Longman; Mina Ahloulay; Françoise Audat; François Lefrerre; Charles M Rice; Stanislas Pol; Matthew L Albert
Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients.
The Journal of experimental medicine 2007;204(10):2423-37.
2007: Catherine L Murray; Christopher T Jones; Jodie Tassello; Charles M Rice
Alanine scanning of the hepatitis C virus core protein reveals numerous residues essential for production of infectious virus.
Journal of virology 2007;81(19):10220-31.
2007: Brett D Lindenbach; Béla M Prágai; Roland Montserret; Rudolf K F Beran; Anna Marie Pyle; François Penin; Charles M Rice
The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication.
Journal of virology 2007;81(17):8905-18.
2007: Timothy L Tellinghuisen; Matthew J Evans; Thomas von Hahn; Shihyun You; Charles M Rice
Studying hepatitis C virus: making the best of a bad virus.
Journal of virology 2007;81(17):8853-67.
2007: Christopher T Jones; Catherine L Murray; Dawnnica K Eastman; Jodie Tassello; Charles M Rice
Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus.
Journal of virology 2007;81(16):8374-83.
2007: Maria Teresa Catanese; Rita Graziani; Thomas von Hahn; Martine Moreau; Thierry Huby; Giacomo Paonessa; Claudia Santini; Alessandra Luzzago; Charles M Rice; Riccardo Cortese; alessandra vitelli; Alfredo Nicosia
High-avidity monoclonal antibodies against the human scavenger class B type I receptor efficiently block hepatitis C virus infection in the presence of high-density lipoprotein.
Journal of virology 2007;81(15):8063-71.
2007: Glenn Randall; Maryline Panis; Jacob D Cooper; Timothy L Tellinghuisen; Karen E Sukhodolets; Sébastien Pfeffer; Markus Landthaler; Pablo Landgraf; Sherry Kan; Brett D Lindenbach; Minchen Chien; David B Weir; James J Russo; Jingyue Ju; Michael J Brownstein; Robert Sheridan; Chris Sander; Mihaela Zavolan; Thomas Tuschl; Charles M Rice
Cellular cofactors affecting hepatitis C virus infection and replication.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12884-9.
2007: Matthew J Evans; Thomas von Hahn; Donna M Tscherne; Andrew J Syder; Maryline Panis; Benno Wölk; Theodora Hatziioannou; Jane A McKeating; Paul D Bieniasz; Charles M Rice
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.
Nature 2007;446(7137):801-5.
2007: Donna M Tscherne; Matthew J Evans; Thomas von Hahn; Christopher T Jones; Zania Stamataki; Jane A McKeating; Brett D Lindenbach; Charles M Rice
Superinfection exclusion in cells infected with hepatitis C virus.
Journal of virology 2007;81(8):3693-703.
2007: Laura McMullan; Arash Grakoui; Matthew J Evans; Kathleen Mihalik; Montserrat Puig; Andrea D Branch; Stephen M Feinstone; Charles M Rice
Evidence for a functional RNA element in the hepatitis C virus core gene.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2879-84.
2007: Thomas von Hahn; Joo Chun Yoon; Harvey Alter; Charles M Rice; Barbara Rehermann; Peter Balfe; Jane A McKeating
Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo.
Gastroenterology 2007;132(2):667-78.
2007: Randy S Longman; Deborah Braun; Sandra Pellegrini; Charles M Rice; Robert B Darnell; Matthew L Albert
Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation.
Blood 2007;109(3):1113-22.
2007: Lynn B Dustin; Charles M Rice
Flying under the radar: the immunobiology of hepatitis C.
Annual review of immunology 2007;25():71-99.
2007: Harel Dahari; Ruy M Ribeiro; Charles M Rice; Alan S Perelson
Mathematical modeling of subgenomic hepatitis C virus replication in Huh-7 cells.
Journal of virology 2007;81(2):750-60.
2006: Tobias Marcello; Arash Grakoui; Giovanna Barba-Spaeth; Erica S Machlin; Sergei V Kotenko; Margaret R MacDonald; Charles M Rice
Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics.
Gastroenterology 2006;131(6):1887-98.
2006: Glenn Randall; Limin Chen; Maryline Panis; Andrew K Fischer; Brett D Lindenbach; Jing Sun; Jenny Heathcote; Charles M Rice; Aled M Edwards; Ian D McGilvray
Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection.
Gastroenterology 2006;131(5):1584-91.
2006: Eui-Cheol Shin; Ulrike Seifert; Takanobu Kato; Charles M Rice; Stephen M Feinstone; Peter-M Kloetzel; Barbara Rehermann
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection.
The Journal of clinical investigation 2006;116(11):3006-14.
2006: Mike Flint; Thomas von Hahn; Jie Zhang; Michelle Farquhar; Christopher T Jones; Peter Balfe; Charles M Rice; Jane A McKeating
Diverse CD81 proteins support hepatitis C virus infection.
Journal of virology 2006;80(22):11331-42.
2006: Ileana M Cristea; John-William N Carroll; Michael P Rout; Charles M Rice; Brian T Chait; Margaret R MacDonald
Tracking and elucidating alphavirus-host protein interactions.
The Journal of biological chemistry 2006;281(40):30269-78.
2006: Ivo C Lorenz; Joseph Marcotrigiano; Thomas G Dentzer; Charles M Rice
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease.
Nature 2006;442(7104):831-5.
2006: Timothy L Tellinghuisen; Matthew S Paulson; Charles M Rice
The NS5A protein of bovine viral diarrhea virus contains an essential zinc-binding site similar to that of the hepatitis C virus NS5A protein.
Journal of virology 2006;80(15):7450-8.
2006: Tobias Manigold; Eui-Cheol Shin; Eishiro Mizukoshi; Kathleen Mihalik; Krishna K Murthy; Charles M Rice; Ciriaco Piccirillo; Barbara Rehermann
Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C.
Blood 2006;107(11):4424-32.
2006: Thomas von Hahn; Brett D Lindenbach; Agnès Boullier; Oswald Quehenberger; Matthew Paulson; Charles M Rice; Jane A McKeating
Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells.
Hepatology (Baltimore, Md.) 2006;43(5):932-42.
2006: Brett D Lindenbach; Philip Meuleman; Alexander Ploss; Thomas Vanwolleghem; Andrew J Syder; Jane A McKeating; Robert E Lanford; Stephen M Feinstone; Marian E Major; Geert Leroux-Roels; Charles M Rice
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3805-9.
2006: Donna M Tscherne; Christopher T Jones; Matthew J Evans; Brett D Lindenbach; Jane A McKeating; Charles M Rice
Time- and temperature-dependent activation of hepatitis C virus for low-pH-triggered entry.
Journal of virology 2006;80(4):1734-41.
2005: Charles M Rice; Shihyun You
Treating hepatitis C: can you teach old dogs new tricks?
Hepatology (Baltimore, Md.) 2005;42(6):1455-8.
2005: Giovanna Barba-Spaeth; Randy S Longman; Matthew L Albert; Charles M Rice
Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes.
The Journal of experimental medicine 2005;202(9):1179-84.
2005: Eui-Cheol Shin; Ulrike Protzer; Andreas Untergasser; Stephen M Feinstone; Charles M Rice; Dana Hasselschwert; Barbara Rehermann
Liver-directed gamma interferon gene delivery in chronic hepatitis C.
Journal of virology 2005;79(21):13412-20.
2005: Brett D Lindenbach; Charles M Rice
Unravelling hepatitis C virus replication from genome to function.
Nature 2005;436(7053):933-8.
2005: David Butera; Svetlana Marukian; Amy E Iwamaye; Edgardo Hembrador; Thomas J Chambers; Adrian M Di Bisceglie; Edgar Charles; Andrew H Talal; Ira M Jacobson; Charles M Rice; Lynn B Dustin
Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C.
Blood 2005;106(4):1175-82.
2005: Randy S Longman; Andrew H Talal; Ira M Jacobson; Charles M Rice; Matthew L Albert
Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C.
The Journal of infectious diseases 2005;192(3):497-503.
2005: Brett D Lindenbach; Matthew J Evans; Andrew J Syder; Benno Wölk; Timothy L Tellinghuisen; Christopher C Liu; Toshiaki Maruyama; Richard O Hynes; Dennis R Burton; Jane A McKeating; Charles M Rice
Complete replication of hepatitis C virus in cell culture.
Science (New York, N.Y.) 2005;309(5734):623-6.
2005: Timothy L Tellinghuisen; Joseph Marcotrigiano; Charles M Rice
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase.
Nature 2005;435(7040):374-9.
2005: Harel Dahari; Marian E Major; Xinan Zhang; Kathleen Mihalik; Charles M Rice; Alan S Perelson; Stephen M Feinstone; Avidan U Neumann
Mathematical modeling of primary hepatitis C infection: noncytolytic clearance and early blockage of virion production.
Gastroenterology 2005;128(4):1056-66.
2005: Sébastien Pfeffer; Alain Sewer; Mariana Lagos-Quintana; Robert Sheridan; Chris Sander; Friedrich A Grässer; Linda F van Dyk; Kiong Ho; Stewart Shuman; Minchen Chien; James J Russo; Jingyue Ju; Glenn Randall; Brett D Lindenbach; Charles M Rice; Viviana Simon; David D Ho; Mihaela Zavolan; Thomas Tuschl
Identification of microRNAs of the herpesvirus family.
Nature methods 2005;2(4):269-76.
2005: Young-Min Lee; Donna M Tscherne; Sang-Im Yun; Ilya Frolov; Charles M Rice
Dual mechanisms of pestiviral superinfection exclusion at entry and RNA replication.
Journal of virology 2005;79(6):3231-42.
2005: Deng Tao; Giovanna Barba-Spaeth; Urvashi Rai; Victor Nussenzweig; Charles M Rice; Ruth S Nussenzweig
Yellow fever 17D as a vaccine vector for microbial CTL epitopes: protection in a rodent malaria model.
The Journal of experimental medicine 2005;201(2):201-9.
2004: Timothy L Tellinghuisen; Joseph Marcotrigiano; Alexander E Gorbalenya; Charles M Rice
The NS5A protein of hepatitis C virus is a zinc metalloprotein.
The Journal of biological chemistry 2004;279(47):48576-87.
2004: Javier Fernandez; Deborah Taylor; Duncan R Morhardt; Kathleen Mihalik; Montserrat Puig; Charles M Rice; Stephen M Feinstone; Marian E Major
Long-term persistence of infection in chimpanzees inoculated with an infectious hepatitis C virus clone is associated with a decrease in the viral amino acid substitution rate and low levels of heterogeneity.
Journal of virology 2004;78(18):9782-9.
2004: Jane A McKeating; L Q Zhang; Carine Logvinoff; Mike Flint; Jie Zhang; Jian Yu; David Butera; David D Ho; Lynn B Dustin; Charles M Rice; Peter Balfe
Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner.
Journal of virology 2004;78(16):8496-505.
2004: Carine Logvinoff; Marian E Major; David W Oldach; S Heyward; Andrew H Talal; Peter Balfe; Stephen M Feinstone; Harvey Alter; Charles M Rice; Jane A McKeating
Neutralizing antibody response during acute and chronic hepatitis C virus infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10149-54.
2004: Darius Moradpour; Matthew J Evans; Rainer Gosert; Zhenghong Yuan; Hubert E Blum; Stephen P Goff; Brett D Lindenbach; Charles M Rice
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes.
Journal of virology 2004;78(14):7400-9.
2004: Mike Flint; Carine Logvinoff; Charles M Rice; Jane A McKeating
Characterization of infectious retroviral pseudotype particles bearing hepatitis C virus glycoproteins.
Journal of virology 2004;78(13):6875-82.
2004: Hao-Ming Chang; Matthew Paulson; Michelle Holko; Charles M Rice; Bryan R G Williams; Isabelle Marié; David E Levy
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9578-83.
2004: Marian E Major; Harel Dahari; Kathleen Mihalik; Montserrat Puig; Charles M Rice; Avidan U Neumann; Stephen M Feinstone
Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees.
Hepatology (Baltimore, Md.) 2004;39(6):1709-20.
2004: Glenn Randall; Charles M Rice
Interfering with hepatitis C virus RNA replication.
Virus research 2004;102(1):19-25.
2004: Eugene V Agapov; Catherine L Murray; Ilya Frolov; Lin Qu; Tina M Myers; Charles M Rice
Uncleaved NS2-3 is required for production of infectious bovine viral diarrhea virus.
Journal of virology 2004;78(5):2414-25.
2004: Jie Zhang; Glenn Randall; Adrian Higginbottom; Peter N Monk; Charles M Rice; Jane A McKeating
CD81 is required for hepatitis C virus glycoprotein-mediated viral infection.
Journal of virology 2004;78(3):1448-55.
2004: Shihyun You; Decherd D Stump; Andrea D Branch; Charles M Rice
A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication.
Journal of virology 2004;78(3):1352-66.
2004: Randy S Longman; Andrew H Talal; Ira M Jacobson; Matthew L Albert; Charles M Rice
Presence of functional dendritic cells in patients chronically infected with hepatitis C virus.
Blood 2004;103(3):1026-9.
2003: Matthew J Bick; John-William N Carroll; Guangxia Gao; Stephen P Goff; Charles M Rice; Margaret R MacDonald
Expression of the zinc-finger antiviral protein inhibits alphavirus replication.
Journal of virology 2003;77(21):11555-62.
2003: Arash Grakoui; Naglaa H Shoukry; David J Woollard; Jin-Hwan Han; Holly L Hanson; John Ghrayeb; Krishna K Murthy; Charles M Rice; Christopher M Walker
HCV persistence and immune evasion in the absence of memory T cell help.
Science (New York, N.Y.) 2003;302(5645):659-62.
2003: Brett D Lindenbach; Charles M Rice
Evasive maneuvers by hepatitis C virus.
Hepatology (Baltimore, Md.) 2003;38(3):769-71.
2003: Mayla Hsu; Jie Zhang; Mike Flint; Carine Logvinoff; Cecilia Cheng-Mayer; Charles M Rice; Jane A McKeating
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7271-6.
2003: Sang-Im Yun; Seok-Yong Kim; Charles M Rice; Young-Min Lee
Development and application of a reverse genetics system for Japanese encephalitis virus.
Journal of virology 2003;77(11):6450-65.
2003: Michelina Nascimbeni; Eishiro Mizukoshi; Markus Bosmann; Marian E Major; Kathleen Mihalik; Charles M Rice; Stephen M Feinstone; Barbara Rehermann
Kinetics of CD4+ and CD8+ memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzees.
Journal of virology 2003;77(8):4781-93.
2003: Jianhua Ni; Edgardo Hembrador; Adrian M Di Bisceglie; Ira M Jacobson; Andrew H Talal; David Butera; Charles M Rice; Thomas J Chambers; Lynn B Dustin
Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3429-39.
2003: Keril J. Blight; Jane A McKeating; Joseph Marcotrigiano; Charles M Rice
Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture.
Journal of virology 2003;77(5):3181-90.
2003: Raffaele De Francesco; Charles M Rice
New therapies on the horizon for hepatitis C: are we close?
Clinics in liver disease 2003;7(1):211-42, xi.
2003: Richard W Hardy; Joseph Marcotrigiano; Keril J. Blight; John E Majors; Charles M Rice
Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells.
Journal of virology 2003;77(3):2029-37.
2003: Glenn Randall; Arash Grakoui; Charles M Rice
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):235-40.
2003: Brett D Lindenbach; Charles M Rice
Molecular biology of flaviviruses.
Advances in virus research 2003;59():23-61.
2002: Keril J. Blight; Jane A McKeating; Charles M Rice
Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication.
Journal of virology 2002;76(24):13001-14.
2002: Timothy L Tellinghuisen; Charles M Rice
Interaction between hepatitis C virus proteins and host cell factors.
Current opinion in microbiology 2002;5(4):419-27.
2002: Linda Buonocore; Keril J. Blight; Charles M Rice; John K Rose
Characterization of vesicular stomatitis virus recombinants that express and incorporate high levels of hepatitis C virus glycoproteins.
Journal of virology 2002;76(14):6865-72.
2002: Marian E Major; Kathleen Mihalik; Montserrat Puig; Barbara Rehermann; Michelina Nascimbeni; Charles M Rice; Stephen M Feinstone
Previously infected and recovered chimpanzees exhibit rapid responses that control hepatitis C virus replication upon rechallenge.
Journal of virology 2002;76(13):6586-95.
2002: Eishiro Mizukoshi; Michelina Nascimbeni; Joshua B Blaustein; Kathleen Mihalik; Charles M Rice; TSANYANG LIANG; Stephen M Feinstone; Barbara Rehermann
Molecular and immunological significance of chimpanzee major histocompatibility complex haplotypes for hepatitis C virus immune response and vaccination studies.
Journal of virology 2002;76(12):6093-103.
2002: Brett D Lindenbach; Charles M Rice
RNAi targeting an animal virus: news from the front.
Molecular cell 2002;9(5):925-7.
2002: Beate M Kümmerer; Charles M Rice
Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles.
Journal of virology 2002;76(10):4773-84.
2001: Glenn Randall; Charles M Rice
Hepatitis C virus cell culture replication systems: their potential use for the development of antiviral therapies.
Current opinion in infectious diseases 2001;14(6):743-7.
2001: J Schmidt-Mende; Elke Bieck; Thomas Hügle; François Penin; Charles M Rice; Hubert E Blum; Darius Moradpour
Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase.
The Journal of biological chemistry 2001;276(47):44052-63.
2001: L Qu; Laura McMullan; Charles M Rice
Isolation and characterization of noncytopathic pestivirus mutants reveals a role for nonstructural protein NS4B in viral cytopathogenicity.
Journal of virology 2001;75(22):10651-62.
2001: Thomas Hügle; Frauke Fehrmann; Elke Bieck; M Kohara; Hans-Georg Kräusslich; Charles M Rice; Hubert E Blum; Darius Moradpour
The hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein.
Virology 2001;284(1):70-81.
2001: T M Myers; Victoria G Kolupaeva; E Mendez; S G Baginski; Ilya Frolov; Christopher U T Hellen; Charles M Rice
Efficient translation initiation is required for replication of bovine viral diarrhea virus subgenomic replicons.
Journal of virology 2001;75(9):4226-38.
2001: Arash Grakoui; Holly L Hanson; Charles M Rice
Bad time for Bonzo? Experimental models of hepatitis C virus infection, replication, and pathogenesis.
Hepatology (Baltimore, Md.) 2001;33(3):489-95.
2001: A Bergqvist; Charles M Rice
Transcriptional activation of the interleukin-2 promoter by hepatitis C virus core protein.
Journal of virology 2001;75(2):772-81.
2000: Keril J. Blight; AA Kolykhalov; Charles M Rice
Efficient initiation of HCV RNA replication in cell culture.
Science (New York, N.Y.) 2000;290(5498):1972-4.
2000: Benno Wölk; D Sansonno; Hans-Georg Kräusslich; F Dammacco; Charles M Rice; Hubert E Blum; Darius Moradpour
Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines.
Journal of virology 2000;74(5):2293-304.
2000: AA Kolykhalov; Kathleen Mihalik; Stephen M Feinstone; Charles M Rice
Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo.
Journal of virology 2000;74(4):2046-51.
2000: KE Reed; Charles M Rice
Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties.
Current topics in microbiology and immunology 2000;242():55-84.
1999: David Kobiler; Charles M Rice; Chaya Brodie; A Shahar; J Dubuisson; Menachem Halevy; Shlomo Lustig
A single nucleotide change in the 5' noncoding region of Sindbis virus confers neurovirulence in rats.
Journal of virology 1999;73(12):10440-6.
1999: S M Amberg; Charles M Rice
Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing.
Journal of virology 1999;73(10):8083-94.
1999: KE Reed; Charles M Rice
Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321.
The Journal of biological chemistry 1999;274(39):28011-8.
1999: Brett D Lindenbach; Charles M Rice
Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function.
Journal of virology 1999;73(6):4611-21.
1999: Ilya Frolov; Eugene V Agapov; T A Hoffman; Béla M Prágai; M Lippa; S Schlesinger; Charles M Rice
Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells.
Journal of virology 1999;73(5):3854-65.
1999: Marian E Major; Kathleen Mihalik; J Fernandez; J Seidman; D Kleiner; AA Kolykhalov; Charles M Rice; Stephen M Feinstone
Long-term follow-up of chimpanzees inoculated with the first infectious clone for hepatitis C virus.
Journal of virology 1999;73(4):3317-25.
1999: Thomas J Chambers; A Nestorowicz; P W Mason; Charles M Rice
Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties.
Journal of virology 1999;73(4):3095-101.
1999: Brett D Lindenbach; Ilya Frolov; Charles M Rice
Construction of recombinant sindbis-based expression vectors for the study of HCV genes and their products.
Methods in molecular medicine 1999;19():565-74.
1999: KE Reed; Charles M Rice
Expression and Characterization of the HCV NS2 Protease.
Methods in molecular medicine 1999;19():331-42.
1999: Eugene V Agapov; KE Reed; Charles M Rice
Use of the vaccinia virus/t7 expression system for studying HCV protein processing.
Methods in molecular medicine 1999;19():303-14.
1999: AA Kolykhalov; KE Reed; Charles M Rice
Cloning and assembly of complex libraries of full-length HCV cDNA clones.
Methods in molecular medicine 1999;19():289-301.
1999: N Ruggli; Charles M Rice
Functional cDNA clones of the Flaviviridae: strategies and applications.
Advances in virus research 1999;53():183-207.
1999: Shlomo Lustig; Menachem Halevy; David Ben-Nathan; Charles M Rice; David Kobiler
The role of host immunocompetence in neuroinvasion of Sindbis virus.
Archives of virology 1999;144(6):1159-71.
1998: Ilya Frolov; M S McBride; Charles M Rice
cis-acting RNA elements required for replication of bovine viral diarrhea virus-hepatitis C virus 5' nontranslated region chimeras.
RNA (New York, N.Y.) 1998;4(11):1418-35.
1998: Eugene V Agapov; Ilya Frolov; Brett D Lindenbach; Béla M Prágai; S Schlesinger; Charles M Rice
Noncytopathic Sindbis virus RNA vectors for heterologous gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12989-94.
1998: Thomas J Chambers; Menachem Halevy; A Nestorowicz; Charles M Rice; Shlomo Lustig
West Nile virus envelope proteins: nucleotide sequence analysis of strains differing in mouse neuroinvasiveness.
The Journal of general virology 1998;79 ( Pt 10)():2375-80.
1998: J A Lemm; A Bergqvist; C M Read; Charles M Rice
Template-dependent initiation of Sindbis virus RNA replication in vitro.
Journal of virology 1998;72(8):6546-53.
1998: Darius Moradpour; P Kary; Charles M Rice; Hubert E Blum
Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins.
Hepatology (Baltimore, Md.) 1998;28(1):192-201.
1998: KE Reed; A E Gorbalenya; Charles M Rice
The NS5A/NS5 proteins of viruses from three genera of the family flaviviridae are phosphorylated by associated serine/threonine kinases.
Journal of virology 1998;72(7):6199-206.
1998: E Mendez; N Ruggli; Marc S Collett; Charles M Rice
Infectious bovine viral diarrhea virus (strain NADL) RNA from stable cDNA clones: a cellular insert determines NS3 production and viral cytopathogenicity.
Journal of virology 1998;72(6):4737-45.
1998: Keril J. Blight; AA Kolykhalov; KE Reed; Eugene V Agapov; Charles M Rice
Molecular virology of hepatitis C virus: an update with respect to potential antiviral targets.
Antiviral therapy 1998;3(Suppl 3):71-81.
1998: KE Reed; Charles M Rice
Molecular characterization of hepatitis C virus.
Current studies in hematology and blood transfusion 1998;(62):1-37.
1997: Brett D Lindenbach; Charles M Rice
trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication.
Journal of virology 1997;71(12):9608-17.
1997: Keril J. Blight; Charles M Rice
Secondary structure determination of the conserved 98-base sequence at the 3' terminus of hepatitis C virus genome RNA.
Journal of virology 1997;71(10):7345-52.
1997: KE Reed; J Xu; Charles M Rice
Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase.
Journal of virology 1997;71(10):7187-97.
1997: AA Kolykhalov; Eugene V Agapov; Keril J. Blight; Kathleen Mihalik; Stephen M Feinstone; Charles M Rice
Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA.
Science (New York, N.Y.) 1997;277(5325):570-4.
1997: J Xu; E Mendez; Paul Caron; Chao Lin; Mark Murcko; Marc S Collett; Charles M Rice
Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication.
Journal of virology 1997;71(7):5312-22.
1997: J Dubuisson; S Lustig; N Ruggli; Y Akov; Charles M Rice
Genetic determinants of Sindbis virus neuroinvasiveness.
Journal of virology 1997;71(4):2636-46.
1997: I R Muylaert; R Galler; Charles M Rice
Genetic analysis of the yellow fever virus NS1 protein: identification of a temperature-sensitive mutation which blocks RNA accumulation.
Journal of virology 1997;71(1):291-8.
1996: Joseph L Kim; K A Morgenstern; Chao Lin; Ted Fox; M D Dwyer; James A Landro; Stephen P Chambers; William Markland; Christopher Lepre; E T O'Malley; S L Harbeson; Charles M Rice; Mark Murcko; Paul Caron; John A Thomson
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.
Cell 1996;87(2):343-55.
1996: Ilya Frolov; T A Hoffman; B M Prágai; S A Dryga; H V Huang; S Schlesinger; Charles M Rice
Alphavirus-based expression vectors: strategies and applications.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11371-7.
1996: I R Muylaert; T J Chambers; R Galler; Charles M Rice
Mutagenesis of the N-linked glycosylation sites of the yellow fever virus NS1 protein: effects on virus replication and mouse neurovirulence.
Virology 1996;222(1):159-68.
1996: AA Kolykhalov; Stephen M Feinstone; Charles M Rice
Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA.
Journal of virology 1996;70(6):3363-71.
1996: Charles M Rice
Alphavirus-based expression systems.
Advances in experimental medicine and biology 1996;397():31-40.
1995: Chao Lin; Charles M Rice
The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7622-6.
1995: Chao Lin; J A Thomson; Charles M Rice
A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro.
Journal of virology 1995;69(7):4373-80.
1995: KE Reed; Arash Grakoui; Charles M Rice
Hepatitis C virus-encoded NS2-3 protease: cleavage-site mutagenesis and requirements for bimolecular cleavage.
Journal of virology 1995;69(7):4127-36.
1995: T J Chambers; A Nestorowicz; Charles M Rice
Mutagenesis of the yellow fever virus NS2B/3 cleavage site: determinants of cleavage site specificity and effects on polyprotein processing and viral replication.
Journal of virology 1995;69(3):1600-5.
1994: Chao Lin; B M Prágai; Arash Grakoui; J Xu; Charles M Rice
Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics.
Journal of virology 1994;68(12):8147-57.
1994: AA Kolykhalov; Eugene V Agapov; Charles M Rice
Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at the 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing.
Journal of virology 1994;68(11):7525-33.
1994: J Dubuisson; H H Hsu; R C Cheung; Harry B Greenberg; D G Russell; Charles M Rice
Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia and Sindbis viruses.
Journal of virology 1994;68(10):6147-60.
1994: M W LaStarza; J A Lemm; Charles M Rice
Genetic analysis of the nsP3 region of Sindbis virus: evidence for roles in minus-strand and subgenomic RNA synthesis.
Journal of virology 1994;68(9):5781-91.
1994: Chao Lin; Brett D Lindenbach; B M Prágai; D W McCourt; Charles M Rice
Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini.
Journal of virology 1994;68(8):5063-73.
1994: M W Lastarza; Arash Grakoui; Charles M Rice
Deletion and duplication mutations in the C-terminal nonconserved region of Sindbis virus nsP3: effects on phosphorylation and on virus replication in vertebrate and invertebrate cells.
Virology 1994;202(1):224-32.
1994: J A Lemm; Till Rümenapf; Ellen G Strauss; James H Strauss; Charles M Rice
Polypeptide requirements for assembly of functional Sindbis virus replication complexes: a model for the temporal regulation of minus- and plus-strand RNA synthesis.
The EMBO journal 1994;13(12):2925-34.
1994: S M Amberg; A Nestorowicz; D W McCourt; Charles M Rice
NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies.
Journal of virology 1994;68(6):3794-802.
1993: Arash Grakoui; D W McCourt; C Wychowski; Stephen M Feinstone; Charles M Rice
A second hepatitis C virus-encoded proteinase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10583-7.
1993: T J Chambers; A Nestorowicz; S M Amberg; Charles M Rice
Mutagenesis of the yellow fever virus NS2B protein: effects on proteolytic processing, NS2B-NS3 complex formation, and viral replication.
Journal of virology 1993;67(11):6797-807.
1993: P J Bredenbeek; Ilya Frolov; Charles M Rice; S Schlesinger
Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs.
Journal of virology 1993;67(11):6439-46.
1993: JoAnn A Suzich; James K Tamura; Frances J Palmer-Hill; Paul Warrener; Arash Grakoui; Charles M Rice; Stephen M Feinstone; Marc S Collett
Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes.
Journal of virology 1993;67(10):6152-8.
1993: Guangpu Li; Charles M Rice
The signal for translational readthrough of a UGA codon in Sindbis virus RNA involves a single cytidine residue immediately downstream of the termination codon.
Journal of virology 1993;67(8):5062-7.
1993: J Dubuisson; Charles M Rice
Sindbis virus attachment: isolation and characterization of mutants with impaired binding to vertebrate cells.
Journal of virology 1993;67(6):3363-74.
1993: Arash Grakoui; D W McCourt; C Wychowski; Stephen M Feinstone; Charles M Rice
Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites.
Journal of virology 1993;67(5):2832-43.
1993: Chao Lin; S M Amberg; T J Chambers; Charles M Rice
Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site.
Journal of virology 1993;67(4):2327-35.
1993: J A Lemm; Charles M Rice
Roles of nonstructural polyproteins and cleavage products in regulating Sindbis virus RNA replication and transcription.
Journal of virology 1993;67(4):1916-26.
1993: J A Lemm; Charles M Rice
Assembly of functional Sindbis virus RNA replication complexes: requirement for coexpression of P123 and P34.
Journal of virology 1993;67(4):1905-15.
1993: Arash Grakoui; C Wychowski; Chao Lin; Stephen M Feinstone; Charles M Rice
Expression and identification of hepatitis C virus polyprotein cleavage products.
Journal of virology 1993;67(3):1385-95.
1993: Chao Lin; T J Chambers; Charles M Rice
Mutagenesis of conserved residues at the yellow fever virus 3/4A and 4B/5 dibasic cleavage sites: effects on cleavage efficiency and polyprotein processing.
Virology 1993;192(2):596-604.
1992: Young S Hahn; Chang S Hahn; Vivian L Braciale; Thomas J Braciale; Charles M Rice
CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope.
The Journal of experimental medicine 1992;176(5):1335-41.
1992: Charles M Rice
Examples of expression systems based on animal RNA viruses: alphaviruses and influenza virus.
Current opinion in biotechnology 1992;3(5):523-32.
1992: Chang S Hahn; Young S Hahn; Thomas J Braciale; Charles M Rice
Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2679-83.
1992: S D London; Alan L Schmaljohn; J M Dalrymple; Charles M Rice
Infectious enveloped RNA virus antigenic chimeras.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):207-11.
1991: Guangpu Li; B M Prágai; Charles M Rice
Rescue of Sindbis virus-specific RNA replication and transcription by using a vaccinia virus recombinant.
Journal of virology 1991;65(12):6714-23.
1991: T J Chambers; Arash Grakoui; Charles M Rice
Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites.
Journal of virology 1991;65(11):6042-50.
1990: Charles M Rice
Overview of flavivirus molecular biology and future vaccine development via recombinant DNA.
The Southeast Asian journal of tropical medicine and public health 1990;21(4):670-7.
1990: T J Chambers; R C Weir; Arash Grakoui; D W McCourt; J. Fernando Bazan; Robert J Fletterick; Charles M Rice
Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8898-902.
1990: Guangpu Li; M W La Starza; W R Hardy; James H Strauss; Charles M Rice
Phosphorylation of Sindbis virus nsP3 in vivo and in vitro.
Virology 1990;179(1):416-27.
1990: T J Chambers; D W McCourt; Charles M Rice
Production of yellow fever virus proteins in infected cells: identification of discrete polyprotein species and analysis of cleavage kinetics using region-specific polyclonal antisera.
Virology 1990;177(1):159-74.
1990: J A Lemm; R K Durbin; Victor Stollar; Charles M Rice
Mutations which alter the level or structure of nsP4 can affect the efficiency of Sindbis virus replication in a host-dependent manner.
Journal of virology 1990;64(6):3001-11.
1990: Young S Hahn; E M Lenches; R Galler; Charles M Rice; J Dalrymple; James H Strauss
Expression of the structural proteins of dengue 2 virus and yellow fever virus by recombinant vaccinia viruses.
Archives of virology 1990;115(3-4):251-65.
1990: T J Chambers; Chang S Hahn; R Galler; Charles M Rice
Flavivirus genome organization, expression, and replication.
Annual review of microbiology 1990;44():649-88.
1989: Arash Grakoui; R Levis; R Raju; H V Huang; Charles M Rice
A cis-acting mutation in the Sindbis virus junction region which affects subgenomic RNA synthesis.
Journal of virology 1989;63(12):5216-27.
1989: Charles M Rice; Arash Grakoui; R Galler; T J Chambers
Transcription of infectious yellow fever RNA from full-length cDNA templates produced by in vitro ligation.
The New biologist 1989;1(3):285-96.
1989: H V Huang; Charles M Rice; Chengjie Xiong; S Schlesinger
RNA viruses as gene expression vectors.
Virus genes 1989;3(1):85-91.
1989: Chang S Hahn; Charles M Rice; Ellen G Strauss; E M Lenches; James H Strauss
Sindbis virus ts103 has a mutation in glycoprotein E2 that leads to defective assembly of virions.
Journal of virology 1989;63(8):3459-65.
1989: C Xiong; R Levis; P Shen; S Schlesinger; Charles M Rice; H V Huang
Sindbis virus: an efficient, broad host range vector for gene expression in animal cells.
Science (New York, N.Y.) 1989;243(4895):1188-91.
1989: T J Chambers; D W McCourt; Charles M Rice
Yellow fever virus proteins NS2A, NS2B, and NS4B: identification and partial N-terminal amino acid sequence analysis.
Virology 1989;169(1):100-9.
1989: Guangpu Li; Charles M Rice
Mutagenesis of the in-frame opal termination codon preceding nsP4 of Sindbis virus: studies of translational readthrough and its effect on virus replication.
Journal of virology 1989;63(3):1326-37.
1989: Young S Hahn; Arash Grakoui; Charles M Rice; Ellen G Strauss; James H Strauss
Mapping of RNA- temperature-sensitive mutants of Sindbis virus: complementation group F mutants have lesions in nsP4.
Journal of virology 1989;63(3):1194-202.
1988: Ellen G Strauss; R Levinson; Charles M Rice; J Dalrymple; James H Strauss
Nonstructural proteins nsP3 and nsP4 of Ross River and O'Nyong-nyong viruses: sequence and comparison with those of other alphaviruses.
Virology 1988;164(1):265-74.
1987: Charles M Rice; R Levis; J H Strauss; H V Huang
Production of infectious RNA transcripts from Sindbis virus cDNA clones: mapping of lethal mutations, rescue of a temperature-sensitive marker, and in vitro mutagenesis to generate defined mutants.
Journal of virology 1987;61(12):3809-19.
1987: Chang S Hahn; Young S Hahn; Charles M Rice; E Lee; L Dalgarno; Ellen G Strauss; James H Strauss
Conserved elements in the 3' untranslated region of flavivirus RNAs and potential cyclization sequences.
Journal of molecular biology 1987;198(1):33-41.
1987: T J Chambers; Charles M Rice
Molecular biology of the flaviviruses.
Microbiological sciences 1987;4(7):219-23.
1985: Charles M Rice; E M Lenches; S R Eddy; S J Shin; R L Sheets; James H Strauss
Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution.
Science (New York, N.Y.) 1985;229(4715):726-33.