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Kenner Rice

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Malliga R Iyer; Arthur E Jacobson; Christina M Dersch; Richard B Rothman; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 47.(1) Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.
Susannah S Lewis; Steven F Maier; Kenner C Rice; Dana K Hund; Mark Hutchinson; Yingning Zhang; Linda R Watkins
Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain.
Estelle Barbier; Kejun Cheng; Scott Edwards; Nathan Juergens; George F Koob; Kaushik K Misra; Paula E Park; Kenner C Rice; Jesse Schank; Joel E Schlosburg; Gery Schulteis; Leandro F Vendruscolo; Markus Heilig
The NK1 receptor antagonist l822429 reduces heroin reinforcement.

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2013: Malliga R Iyer; Arthur E Jacobson; Christina M Dersch; Richard B Rothman; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 47.(1) Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.
Bioorganic & medicinal chemistry 2013;21(11):3298-309.
2013: Susannah S Lewis; Steven F Maier; Kenner C Rice; Dana K Hund; Mark Hutchinson; Yingning Zhang; Linda R Watkins
Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain.
Brain, behavior, and immunity 2013;30():24-32.
2013: Estelle Barbier; Kejun Cheng; Scott Edwards; Nathan Juergens; George F Koob; Kaushik K Misra; Paula E Park; Kenner C Rice; Jesse Schank; Joel E Schlosburg; Gery Schulteis; Leandro F Vendruscolo; Markus Heilig
The NK1 receptor antagonist l822429 reduces heroin reinforcement.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013;38(6):976-84.
2013: Jesse R Schank; Matthew G Solomon; Hui Sun; Jenica D Tapocik; Mengdi Yao; Estelle Barbier; Kejun Cheng; Ruslan Damadzic; Robert L Eskay; Meghan E Flanigan; Camilla Karlsson; Courtney E King; Kenner C Rice; Kelly E Rowe; Markus Heilig
Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats.
Biological psychiatry 2013;73(8):774-81.
2013: Florence R Theberge; Linda R Watkins; Robyn St Laurent; Michael H Baumann; Jennifer M Bossert; Mark R Hutchinson; Sarita Kambhampati; Xuan Li; Charles L Pickens; Kenner C Rice; Yavin Shaham
Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving.
Biological psychiatry 2013;73(8):729-37.
2013: Maria A Briscione; Andrew P Merluzzi; Kenner C Rice; Katherine M Serafine; Anthony L Riley
The effects of the 5-HT3 receptor antagonist tropisetron on cocaine-induced conditioned taste aversions.
Pharmacology, biochemistry, and behavior 2013;105():112-7.
2013: Valentina Sabino; Jina Kwak; Kenner C Rice; Pietro Cottone
Pharmacological characterization of the 20% alcohol intermittent access model in sardinian alcohol-preferring rats: a model of binge-like drinking.
Alcoholism, clinical and experimental research 2013;37(4):635-43.
2013: Wouter Koek; Kejun Cheng; Kenner C Rice
Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.
The Journal of pharmacology and experimental therapeutics 2013;344(3):553-60.
2013: William E Fantegrossi; Brenda M Gannon; Sarah M Zimmerman; Kenner C Rice
In vivo effects of abused 'bath salt' constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, thermoregulation, and locomotor activity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013;38(4):563-73.
2013: William T Birdsong; Kejun Cheng; Mary J Clark; Kenner C Rice; John R Traynor; Seksiri Arttamangkul; John T Williams
Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(9):4118-27.
2013: Agnieszka Sulima; Kenner C Rice; Kejun Cheng; Klaus Gawrisch; Arthur E Jacobson; Yong-Sok Lee
Z and E rotamers of N-formyl-1-bromo-4-hydroxy-3-methoxymorphinan-6-one and their interconversion as studied by 1H/13C NMR spectroscopy and quantum chemical calculations.
Magnetic resonance in chemistry : MRC 2013;51(2):82-8.
2013: Jun-Xu Li; Sunny K Patel; Kenner C Rice; Aparna P Shah; Charles France
Modification of the behavioral effects of morphine in rats by serotonin (5-HT)₁A and 5-HT₂A receptor agonists: antinociception, drug discrimination, and locomotor activity.
Psychopharmacology 2013;225(4):791-801.
2013: Kathryn A Cunningham; Robert G Fox; Scott R Gilbertson; Kenner C Rice; Sharon Rosenzweig-Lipson; Sonja J Stutz; Sarah E Swinford; Cheryl S Watson; Noelle C Anastasio; Marcy J Bubar; F. Gerard Moeller
Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction.
ACS chemical neuroscience 2013;4(1):110-21.
2012: Fuying Li; Richard B Rothman; Jason A Deck; Christina M Dersch; Jeffrey R Deschamps; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 46. N-substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols - carbocyclic relatives of f-oxide-bridged phenylmorphans.
European journal of medicinal chemistry 2012;58():557-67.
2012: Pietro Cottone; Teruo Hayashi; Malliga R Iyer; Jina Kwak; Jin Won Park; Kenner C Rice; Luca Steardo; Marta Valenza; Xiaofan Wang; Angelo Blasio; Valentina Sabino
Antagonism of sigma-1 receptors blocks compulsive-like eating.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(12):2593-604.
2012: Ajay S Yekkirala; Kenner C Rice; Matthew L Banks; Mary M Lunzer; Stevens S Negus; Philip S Portoghese
Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys.
ACS chemical neuroscience 2012;3(9):720-7.
2012: Sarah L Parylak; Kenner C Rice; Valentina Sabino; Pietro Cottone; Eric P Zorrilla
Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses.
Physiology & behavior 2012;107(2):231-42.
2012: Mark Hutchinson; J L Katz; Theresa A Kopajtic; S S Lewis; L C Loram; Steven F Maier; T Maslanik; N E Miles; A L Northcutt; Kenner C Rice; R R Rozeske; C Sfregola; Andrew A Somogyi; K A Strand; J Thomas; K van Steeg; X Wang; Jose Amat; Ryan K Bachtell; Sondra T Bland; T R Chapman; Monika Fleshner; E Galer; Takato Hiranita; H Yin; Linda R Watkins
Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(33):11187-200.
2012: Joseph Tam; Daniel Wesley; Jeih-San Liow; Jie Liu; John F McElroy; Bani Mukhopadhyay; Kenner C Rice; Gergő Szanda; Lee Chedester; Kejun Cheng; Robert J Chorvat; Resat Cinar; Jeffrey R Deschamps; Grzegorz Godlewski; Robert B Innis; Tony Jourdan; George Kunos
Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance.
Cell metabolism 2012;16(2):167-79.
2012: Mikhail N Koffarnus; Kenner C Rice; Jianyong Chen; Gregory Collins; James H Woods; Gail Winger
Self-administration of agonists selective for dopamine D2, D3, and D4 receptors by rhesus monkeys.
Behavioural pharmacology 2012;23(4):331-8.
2012: Katherine M Serafine; Maria A Briscione; Kenner C Rice; Anthony L Riley
Dopamine mediates cocaine-induced conditioned taste aversions as demonstrated with cross-drug preexposure to GBR 12909.
Pharmacology, biochemistry, and behavior 2012;102(2):269-74.
2012: Eileen K Sawyer; Jeffrey S Stehouwer; Ronald J Voll; Mark M Goodman; Heather L Kimmel; Jiyoung Mun; Jonathon A Nye; Kenner C Rice; Leonard L Howell
Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(8):1816-24.
2012: Susannah S Lewis; Chien-Ming Li; Lisa C Loram; Steven F Maier; Kenner C Rice; Yong Huang; Mark R Hutchinson; Yingning Zhang; Linda R Watkins
(+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats.
The journal of pain : official journal of the American Pain Society 2012;13(5):498-506.
2012: Wouter Koek; Kejun Cheng; Charles France; Kenner C Rice
Effects of the GABAB receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons.
The Journal of pharmacology and experimental therapeutics 2012;341(2):369-76.
2012: Terrence L Boos; Kejun Cheng; Jeffrey Deschamps; Elisabeth Greiner; Arthur E Jacobson; Kenner C Rice
Configurational reassignment and improved preparation of the competitive IL-6 receptor antagonist 20R,21R-epoxyresibufogenin-3-formate.
Journal of natural products 2012;75(4):661-8.
2012: Robert A Rissman; Nicholas J Justice; Allyson Roe Lee; Kenner C Rice; Michael A Staup; Wylie Vale; Paul E Sawchenko
Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6277-82.
2012: S Stevens Negus; Robert H O'Connell; Ahmad A Altarifi; John E Folk; Marisa B Rosenberg; Kenner C Rice
Effects of the δ opioid receptor agonist SNC80 on pain-related depression of intracranial self-stimulation (ICSS) in rats.
The journal of pain : official journal of the American Pain Society 2012;13(4):317-27.
2012: Malliga R Iyer; Arthur E Jacobson; Yong-Sok Lee; Christina M Dersch; Jeffrey R Deschamps; Richard B Rothman; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl)morphan with high affinity and selective μ-antagonist activity.
European journal of medicinal chemistry 2012;50():44-54.
2012: S Stevens Negus; Robert O'Connell; Kejun Cheng; Ember Morrissey; Kenner C Rice
Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats.
The Journal of pharmacology and experimental therapeutics 2012;340(3):501-9.
2012: Yue Wu; Janet K Coller; John D Hayball; Erin L Lousberg; Lachlan M Moldenhauer; Kenner C Rice; Andrew A Somogyi; Linda R Watkins; Mark Hutchinson
Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.
British journal of pharmacology 2012;165(5):1319-29.
2012: Tomohiro Kimura; Steven D Rhodes; Kenner C Rice; Krishna Vukoti; Alexei Yeliseev; Kejun Cheng; Klaus Gawrisch
Recombinant cannabinoid type 2 receptor in liposome model activates g protein in response to anionic lipid constituents.
The Journal of biological chemistry 2012;287(6):4076-87.
2012: Tian-Zhi Guo; Saiyun Hou; Kejun Cheng; David J Clark; Wen-Wu Li; Kenner C Rice; Xiaoyou Shi; Kazutake Tsujikawa; Liping Wang; Tzuping Wei; Wade S Kingery
Neuropeptide deficient mice have attenuated nociceptive, vascular, and inflammatory changes in a tibia fracture model of complex regional pain syndrome.
Molecular pain 2012;8():85.
2012: S Stevens Negus; John E Folk; Ember M Morrissey; Kenner C Rice
Interaction between Mu and Delta Opioid Receptor Agonists in an Assay of Capsaicin-Induced Thermal Allodynia in Rhesus Monkeys.
Pain research and treatment 2012;2012():867067.
2011: Jesse R Schank; Yavin Shaham; Annika Thorsell; Kejun Cheng; Charles L Pickens; Kenner C Rice; Kelly E Rowe; Markus Heilig
Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429.
Psychopharmacology 2011;218(1):111-9.
2011: Hwan Jung Lim; Jeffrey R Deschamps; Arthur E Jacobson; Kenner C Rice
Diastereoselective one-pot synthesis of 7- and 8-substituted 5-phenylmorphans.
Organic letters 2011;13(19):5322-5.
2011: Emily Jutkiewicz; Adam D Kynaston; Kenner C Rice; Emily A Brooks; James H Woods
Patterns of nicotinic receptor antagonism: nicotine discrimination studies.
The Journal of pharmacology and experimental therapeutics 2011;339(1):194-202.
2011: Mark Hutchinson; Steven F Maier; Kenner C Rice; Yehuda Shavit; Peter Grace; Linda R Watkins
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia.
Pharmacological reviews 2011;63(3):772-810.
2011: Jerrold C Winter; D J Amorosi; Kejun Cheng; Kenner C Rice; Ai-Ming Yu
Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice.
Pharmacology, biochemistry, and behavior 2011;99(3):311-5.
2011: Elaine M Jagoda; Carlo Contoreggi; William C Eckelman; B Moon Kim; Lixin Lang; Ying Ma; Karen McCullough; Kenner C Rice; Lawrence P Szajek; Dale O Kiesewetter
[(76) Br]BMK-152, a nonpeptide analogue, with high affinity and low nonspecific binding for the corticotropin-releasing factor type 1 receptor.
Synapse (New York, N.Y.) 2011;65(9):910-8.
2011: Mikhail N Koffarnus; Amy H Newman; Kenner C Rice; Peter Grundt; James H Woods
Effects of selective dopaminergic compounds on a delay-discounting task.
Behavioural pharmacology 2011;22(4):300-11.
2011: Matthew L Banks; John E Folk; Kenner C Rice; Peter G Roma; S Stevens Negus
Effects of the delta-opioid agonist SNC80 on the abuse liability of methadone in rhesus monkeys: a behavioral economic analysis.
Psychopharmacology 2011;216(3):431-9.
2011: Feng Li; Richard B Rothman; Kejun Cheng; Jason A Deck; Christina M Dersch; Jeffrey Deschamps; John E Folk; Arthur E Jacobson; Muneaki Kurimura; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 43. Synthesis of the ortho-a and para-a, and improved synthesis and optical resolution of the ortho-b and para-b oxide-bridged phenylmorphans: compounds with moderate to low opioid-receptor affinity.
Bioorganic & medicinal chemistry 2011;19(14):4330-7.
2011: Jin-Hee Kim; Jeffrey Deschamps; Richard B Rothman; Christina M Dersch; John E Folk; Kejun Cheng; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. Part 42: synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans.
Bioorganic & medicinal chemistry 2011;19(11):3434-43.
2011: Noelle C Anastasio; Erin C Stoffel; Robert G Fox; Marcy J Bubar; Kenner C Rice; Frederick G Moeller; Kathryn A Cunningham
Serotonin (5-hydroxytryptamine) 5-HT(2A) receptor: association with inherent and cocaine-evoked behavioral disinhibition in rats.
Behavioural pharmacology 2011;22(3):248-61.
2011: Wei Xiong; Kejun Cheng; Tanxing Cui; Grzegorz Godlewski; Kenner C Rice; Yan Xu; Li Zhang
Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.
Nature chemical biology 2011;7(5):296-303.
2011: Valentina Sabino; Pietro Cottone; Angelo Blasio; Malliga R Iyer; Luca Steardo; Kenner C Rice; Bruno Conti; George F Koob; Eric P Zorrilla
Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(6):1207-18.
2011: Jun-Xu Li; Wouter Koek; Kenner C Rice; Charles France
Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(5):940-9.
2011: Kejun Cheng; Yong-Sok Lee; Richard B Rothman; Christina M Dersch; Ross W Bittman; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 41. Unusual inverse μ-agonists and potent μ-opioid antagonists by modification of the N-substituent in enantiomeric 5-(3-hydroxyphenyl)morphans.
Journal of medicinal chemistry 2011;54(4):957-69.
2011: Jun-Xu Li; Caroline Crocker; Wouter Koek; Kenner C Rice; Charles France
Effects of serotonin (5-HT)1A and 5-HT2A receptor agonists on schedule-controlled responding in rats: drug combination studies.
Psychopharmacology 2011;213(2-3):489-97.
2010: Matthew L Banks; John E Folk; Kenner C Rice; S Stevens Negus
Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics.
Pharmacology, biochemistry, and behavior 2010;97(2):205-12.
2010: Richard B Rothman; Michael H Baumann; Bruce E Blough; Arthur E Jacobson; Kenner C Rice; John S Partilla
Evidence for noncompetitive modulation of substrate-induced serotonin release.
Synapse (New York, N.Y.) 2010;64(11):862-9.
2010: Matthew L Banks; Kenner C Rice; S Stevens Negus
Antinociceptive interactions between Mu-opioid receptor agonists and the serotonin uptake inhibitor clomipramine in rhesus monkeys: role of Mu agonist efficacy.
The Journal of pharmacology and experimental therapeutics 2010;335(2):497-505.
2010: Marina Vardanyan; Ohannes K Melemedjian; Theodore J Price; Michael H Ossipov; Josephine Lai; Ed Roberts; Terrence L Boos; Jeffrey R Deschamps; Arthur E Jacobson; Kenner C Rice; Frank Porreca
Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist.
Pain 2010;151(2):257-65.
2010: Wouter Koek; Charles France; Kejun Cheng; Kenner C Rice
GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo.
The Journal of pharmacology and experimental therapeutics 2010;335(1):163-71.
2010: Mark Hutchinson; L C Loram; Y Zhang; M Shridhar; N Rezvani; D Berkelhammer; Simon Phipps; P S Foster; K Landgraf; J J Falke; Kenner C Rice; Steven F Maier; H Yin; Linda R Watkins
Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.
Neuroscience 2010;168(2):551-63.
2010: S Stevens Negus; Ember M Morrissey; Marisa Rosenberg; K Cheng; Kenner C Rice
Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.
Psychopharmacology 2010;210(2):149-59.
2010: Mark Hutchinson; S S Lewis; B D Coats; N Rezvani; Y Zhang; J L Wieseler; A A Somogyi; H Yin; Steven F Maier; Kenner C Rice; Linda R Watkins
Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.
Neuroscience 2010;167(3):880-93.
2010: Sylvie De Bruyne; Leonie Wyffels; Terrence L Boos; Steven Staelens; Steven Deleye; Kenner C Rice; Filip De Vos
In vivo evaluation of [123I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine, an iodinated SPECT tracer for imaging the P-gp transporter.
Nuclear medicine and biology 2010;37(4):469-77.
2010: Jun-Xu Li; Wouter Koek; Kenner C Rice; Charles France
Differential effects of serotonin 5-HT1A receptor agonists on the discriminative stimulus effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rats and rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 2010;333(1):244-52.
2010: Elliott J Sally; Heng Xu; Christina M Dersch; Ling-Wei Hsin; Li-Te Chang; Thomas E Prisinzano; Denise S Simpson; Denise Giuvelis; Kenner C Rice; Arthur E Jacobson; Kejun Cheng; Edward J Bilsky; Richard B Rothman
Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor.
Synapse (New York, N.Y.) 2010;64(4):280-8.
2010: S Stevens Negus; M L Banks; J E Folk; Kenner C Rice
Modulation of delta opioid agonist-induced antinociception by repeated morphine pretreatment in rhesus monkeys.
Life sciences 2010;86(11-12):385-92.
2010: S S Lewis; Mark Hutchinson; N Rezvani; L C Loram; Y Zhang; Steven F Maier; Kenner C Rice; Linda R Watkins
Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
Neuroscience 2010;165(2):569-83.
2010: Malliga R Iyer; Yong-Sok Lee; Jeffrey Deschamps; Richard B Rothman; Christina M Dersch; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 40. N-substituted cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-8-ols.
Bioorganic & medicinal chemistry 2010;18(1):91-9.
2010: Mark Hutchinson; Yingning Zhang; Mitesh Shridhar; John H Evans; Madison M Buchanan; Tina X Zhao; Peter F Slivka; Benjamen D Coats; Niloofar Rezvani; Julie Wieseler; Travis S Hughes; Kyle E Landgraf; Stefanie Chan; Stephanie Fong; Simon Phipps; Joseph J Falke; Leslie A Leinwand; Steven F Maier; Hang Yin; Kenner C Rice; Linda R Watkins
Evidence that opioids may have toll-like receptor 4 and MD-2 effects.
Brain, behavior, and immunity 2010;24(1):83-95.
2009: Mark Hutchinson; K M Ramos; L C Loram; J Wieseler; P W Sholar; J J Kearney; M T Lewis; N Y Crysdale; Y Zhang; J A Harrison; Steven F Maier; Kenner C Rice; Linda R Watkins
Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
Neuroscience 2009;164(4):1821-32.
2009: Yi Zhang; Yong-Sok Lee; Richard B Rothman; Christina M Dersch; Jeffrey Deschamps; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 39. Enantiomeric N-substituted benzofuro[2,3-c]pyridin-6-ols: synthesis and topological relationship to oxide-bridged phenylmorphans.
Journal of medicinal chemistry 2009;52(23):7570-9.
2009: Pietro Cottone; Valentina Sabino; Marisa Roberto; Michal Bajo; Lara Pockros; Jennifer B Frihauf; Eva Fekete; Luca Steardo; Kenner C Rice; Dimitri E Grigoriadis; Bruno Conti; George F Koob; Eric P Zorrilla
CRF system recruitment mediates dark side of compulsive eating.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(47):20016-20.
2009: Linda R Watkins; Mark Hutchinson; Kenner C Rice; Steven F Maier
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia.
Trends in pharmacological sciences 2009;30(11):581-91.
2009: Jun-Xu Li; Alison Unzeitig; Martin A Javors; Kenner C Rice; Wouter Koek; Charles France
Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), ketanserin, and (R)-(+)-{alpha}-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in rats.
The Journal of pharmacology and experimental therapeutics 2009;331(2):671-9.
2009: Arati Kreibich; Lisa Briand; Jessica N Cleck; Laurel Ecke; Kenner C Rice; Julie A Blendy
Stress-induced potentiation of cocaine reward: a role for CRF R1 and CREB.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(12):2609-17.
2009: Catherine Davis; Kenner C Rice; Anthony L Riley
Opiate-agonist induced taste aversion learning in the Fischer 344 and Lewis inbred rat strains: evidence for differential mu opioid receptor activation.
Pharmacology, biochemistry, and behavior 2009;93(4):397-405.
2009: Ilona Klejbor; Aaron Kucinski; Scott R Wersinger; Thomas Corso; Jan H Spodnik; Jerzy Dziewiatkowski; Janusz Moryś; Renae A Hesse; Kenner C Rice; Robert Miletich; Ewa K Stachowiak; Michal K Stachowiak
Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis.
Schizophrenia research 2009;113(2-3):308-21.
2009: Tomohiro Kimura; Kejun Cheng; Kenner C Rice; Klaus Gawrisch
Location, structure, and dynamics of the synthetic cannabinoid ligand CP-55,940 in lipid bilayers.
Biophysical journal 2009;96(12):4916-24.
2009: Valentina Sabino; Pietro Cottone; Yu Zhao; Malliga R Iyer; Luca Steardo; Luca Steardo; Kenner C Rice; Bruno Conti; George F Koob; Eric P Zorrilla
The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(6):1482-93.
2009: Walter Francesconi; Fulvia Berton; Vez Repunte-Canonigo; Kazuki Hagihara; David Thurbon; Dusan Lekic; Sheila E Specio; Thomas N Greenwell; Scott A Chen; Kenner C Rice; Heather N Richardson; Laura E O'Dell; Eric P Zorrilla; Marisela Morales; George F Koob; Pietro Paolo Sanna
Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(17):5389-401.
2009: B A Nic Dhonnchadha; R G Fox; S J Stutz; Kenner C Rice; Kathryn A Cunningham
Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model.
Behavioral neuroscience 2009;123(2):382-96.
2009: Thomas N Greenwell; Cindy K Funk; Pietro Cottone; Heather N Richardson; Scott A Chen; Kenner C Rice; Eric P Zorrilla; George F Koob
Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats.
Addiction biology 2009;14(2):130-43.
2009: Gregory Collins; Andrew Truccone; Faiza Haji-Abdi; Amy Hauck Newman; Peter Grundt; Kenner C Rice; Stephen M Husbands; Benjamin M Greedy; Cecile Enguehard-Gueiffier; Alain Gueiffier; Jianyong Chen; Shaomeng Wang; Jonathan L Katz; David K Grandy; Roger K Sunahara; James H Woods
Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice.
The Journal of pharmacology and experimental therapeutics 2009;329(1):210-7.
2009: Stephen J Kohut; Peter G Roma; Catherine Davis; Gerald Zernig; Alois Saria; Juan M Dominguez; Kenner C Rice; Anthony L Riley
The impact of early environmental rearing condition on the discriminative stimulus effects and Fos expression induced by cocaine in adult male and female rats.
Psychopharmacology 2009;203(2):383-97.
2009: Catherine Davis; Glenn W Stevenson; Fernando Cañadas; Thomas Ullrich; Kenner C Rice; Anthony L Riley
Discriminative stimulus properties of naloxone in Long-Evans rats: assessment with the conditioned taste aversion baseline of drug discrimination learning.
Psychopharmacology 2009;203(2):421-9.
2009: Jun-Xu Li; Kenner C Rice; Charles France
Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys: antagonism and apparent pA2 analyses.
The Journal of pharmacology and experimental therapeutics 2009;328(3):976-81.
2009: S Stevens Negus; Kenner C Rice
Mechanisms of withdrawal-associated increases in heroin self-administration: pharmacologic modulation of heroin vs food choice in heroin-dependent rhesus monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(4):899-911.
2009: Gail Pereira Do Carmo; John E Folk; Kenner C Rice; Elena Chartoff; William A Carlezon; S Stevens Negus
The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats.
European journal of pharmacology 2009;604(1-3):58-65.
2009: Zhiguo Nie; Eric P Zorrilla; Samuel G Madamba; Kenner C Rice; Marissa Roberto; George Robert Siggins
Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala.
TheScientificWorldJournal 2009;9():68-85.
2008: Peter G Roma; Jennifer Rinker; Katherine M Serafine; Scott A Chen; Christina S Barr; Kejun Cheng; Kenner C Rice; Anthony L Riley
Genetic and early environmental contributions to alcohol's aversive and physiological effects.
Pharmacology, biochemistry, and behavior 2008;91(1):134-9.
2008: Gail Pereira Do Carmo; Robin Polt; Edward J Bilsky; Kenner C Rice; S Stevens Negus
Behavioral pharmacology of the mu/delta opioid glycopeptide MMP2200 in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 2008;326(3):939-48.
2008: Josef Zezula; Lisa Singer; Anna K Przybył; Akihiro Hashimoto; Christina M Dersch; Richard B Rothman; Jeffrey Deschamps; Yong-Sok Lee; Arthur E Jacobson; Kenner C Rice
Synthesis and pharmacological effects of the enantiomers of the N-phenethyl analogues of the ortho and para e- and f-oxide-bridged phenylmorphans.
Organic & biomolecular chemistry 2008;6(16):2868-83.
2008: John M Rutherford; Jia Bei Wang; Heng Xu; Christina M Dersch; John S Partilla; Kenner C Rice; Richard B Rothman
Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors.
Peptides 2008;29(8):1424-31.
2008: Mark Hutchinson; Yingning Zhang; Kimberley Brown; Benjamen D Coats; Mitesh Shridhar; Paige W Sholar; Sonica J Patel; Nicole Y Crysdale; Jacqueline A Harrison; Steven F Maier; Kenner C Rice; Linda R Watkins
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).
The European journal of neuroscience 2008;28(1):20-9.
2008: Thomas L Horn; J Brooks Harder; William D Johnson; Patrick T Curry; Ralph E Parchment; Robert L Morrissey; Paul W Mellick; Karim A Calis; Philip W Gold; Kenner C Rice; Carlo Contoreggi; Dennis S Charney; Giovanni Cizza; Elizabeth R Glaze; Joseph E Tomaszewski; David L McCormick
Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist.
Toxicology 2008;248(1):8-17.
2008: Ling-Wei Hsin; Li-Te Chang; Richard B Rothman; Christina M Dersch; Arthur E Jacobson; Kenner C Rice
Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters.
Journal of medicinal chemistry 2008;51(9):2795-806.
2008: XIAOJU YANG; Shelun Wang; Kenner C Rice; Cynthia A Munro; Gary S Wand
Restraint stress and ethanol consumption in two mouse strains.
Alcoholism, clinical and experimental research 2008;32(5):840-52.
2008: John E Pascoe; KL Williams; Partha Mukhopadhyay; Kenner C Rice; James H Woods; Mei-Chuan Ko
Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys.
Psychoneuroendocrinology 2008;33(4):478-86.
2008: Jun-Xu Li; Kenner C Rice; Charles France
Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 2008;324(2):827-33.
2008: Emily Jutkiewicz; Michelle G Baladi; John E Folk; Kenner C Rice; James H Woods
The delta-opioid receptor agonist SNC80 [(+)-4-[alpha(R)-alpha-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl]-(3-methoxybenzyl)-N,N-diethylbenzamide] synergistically enhances the locomotor-activating effects of some psychomotor stimulants, but not direct dopamine agonists, in rats.
The Journal of pharmacology and experimental therapeutics 2008;324(2):714-24.
2008: Chad J Reissig; Justin R Eckler; Richard A Rabin; Kenner C Rice; Jerrold C Winter
The stimulus effects of 8-OH-DPAT: evidence for a 5-HT2A receptor-mediated component.
Pharmacology, biochemistry, and behavior 2008;88(3):312-7.
2008: William E Fantegrossi; Chad J Reissig; Elyse B Katz; Haley L Yarosh; Kenner C Rice; Jerrold C Winter
Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents.
Pharmacology, biochemistry, and behavior 2008;88(3):358-65.
2007: Yu Zhao; Glenn R Valdez; Eva Fekete; Jean E Rivier; Wylie W Vale; Kenner C Rice; Friedbert Weiss; Eric P Zorrilla
Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats.
The Journal of pharmacology and experimental therapeutics 2007;323(3):846-54.
2007: Peter W Marinelli; Douglas Funk; Walter Juzytsch; Stephen Harding; Kenner C Rice; Yavin Shaham; Anh Dzung Lê
The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats.
Psychopharmacology 2007;195(3):345-55.
2007: Jerrold C Winter; Kenner C Rice; D J Amorosi; Richard A Rabin
Psilocybin-induced stimulus control in the rat.
Pharmacology, biochemistry, and behavior 2007;87(4):472-80.
2007: Anne-Cécile Hiebel; Yong-Sok Lee; Edward J Bilsky; Denise Giuvelis; Jeffrey Deschamps; Damon Parrish; Mario D Aceto; Everette L May; Louis S Harris; Andrew Coop; Christina M Dersch; John S Partilla; Richard B Rothman; Kejun Cheng; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series.
Journal of medicinal chemistry 2007;50(16):3765-76.
2007: Tomoshige Kino; Terrence L Boos; Agnieszka Sulima; Elise M Siegel; Philip W Gold; Kenner C Rice; George Chrousos
3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6-type cytokine actions by targeting the glycoprotein 130 subunit: potential clinical implications.
The Journal of allergy and clinical immunology 2007;120(2):437-44.
2007: Bin Wang; Zhi-Bing You; Kenner C Rice; Roy A Wise
Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat.
Psychopharmacology 2007;193(2):283-94.
2007: Gregory Collins; Amy Hauck Newman; Peter Grundt; Kenner C Rice; Stephen M Husbands; Cédric Chauvignac; Jianyong Chen; Shaomeng Wang; James H Woods
Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists.
Psychopharmacology 2007;193(2):159-70.
2007: Jun-Xu Li; Kenner C Rice; Charles France
Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity.
Behavioural pharmacology 2007;18(4):283-8.
2007: Tomoshige Kino; Kenner C Rice; George Chrousos
The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition.
European journal of clinical investigation 2007;37(5):425-33.
2007: Kejun Cheng; In Jong Kim; Mei-Jing Lee; Steven A Adah; Tyler J Raymond; Edward J Bilsky; Mario D Aceto; Everette L May; Louis S Harris; Andrew Coop; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists.
Organic & biomolecular chemistry 2007;5(8):1177-90.
2007: Kathleen M Gilbert; Terrence L Boos; Christina M Dersch; Elisabeth Greiner; Arthur E Jacobson; David Lewis; Dorota Matecka; Thomas E Prisinzano; Ying Zhang; Richard B Rothman; Kenner C Rice; Carol A Venanzi
DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods.
Bioorganic & medicinal chemistry 2007;15(2):1146-59.
2007: Mark Hutchinson; Sondra T Bland; Kirk W Johnson; Kenner C Rice; Steven F Maier; Linda R Watkins
Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward.
TheScientificWorldJournal 2007;7():98-111.
2007: Cindy K Funk; Eric P Zorrilla; Mei-Jing Lee; Kenner C Rice; George F Koob
Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats.
Biological psychiatry 2007;61(1):78-86.
2006: Nancy K Mello; S Stevens Negus; Kenner C Rice; Jack H Mendelson
Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys.
Pharmacology, biochemistry, and behavior 2006;85(4):744-51.
2006: Valentina Sabino; Pietro Cottone; George F Koob; Luca Steardo; Mei J Lee; Kenner C Rice; Eric P Zorrilla
Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats.
Psychopharmacology 2006;189(2):175-86.
2006: Ivana Grakalic; Charles W Schindler; Michael H Baumann; Kenner C Rice; Anthony L Riley
Effects of stress modulation on morphine-induced conditioned place preferences and plasma corticosterone levels in Fischer, Lewis, and Sprague-Dawley rat strains.
Psychopharmacology 2006;189(3):277-86.
2006: Susan K Wood; Robert E Verhoeven; Aaron Z Savit; Kenner C Rice; Peter S Fischbach; James H Woods
Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(12):2580-90.
2006: Gail Pereira Do Carmo; Nancy K Mello; Kenner C Rice; John E Folk; S Stevens Negus
Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys.
European journal of pharmacology 2006;547(1-3):92-100.
2006: Ingela Danielsson; Maciej Gasior; Glenn W Stevenson; John E Folk; Kenner C Rice; S Stevens Negus
Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys.
Pharmacology, biochemistry, and behavior 2006;85(2):428-34.
2006: Udi E Ghitza; Sarah M Gray; David H Epstein; Kenner C Rice; Yavin Shaham
The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(10):2188-96.
2006: Anat Milman; Ronit Weizman; Tova Rigai; Kenner C Rice; Chaim Pick
Behavioral effects of opioid subtypes compared with benzodiazepines in the staircase paradigm.
Behavioural brain research 2006;170(1):141-7.
2006: Terrence L Boos; Elisabeth Greiner; W Jason Calhoun; Thomas E Prisinzano; Barbara Nightingale; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter.
Bioorganic & medicinal chemistry 2006;14(11):3967-73.
2006: Emily Jutkiewicz; Michelle G Baladi; John E Folk; Kenner C Rice; James H Woods
The convulsive and electroencephalographic changes produced by nonpeptidic delta-opioid agonists in rats: comparison with pentylenetetrazol.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1337-48.
2006: Meredith A Fox; Glenn W Stevenson; Kenner C Rice; Anthony L Riley
Naloxone, not proglumide or MK-801, alters effects of morphine preexposure on morphine-induced taste aversions.
Pharmacology, biochemistry, and behavior 2006;84(1):169-77.
2006: Jennifer L Taylor; Christopher Bishop; Thomas Ullrich; Kenner C Rice; Paul D Walker
Serotonin 2A receptor antagonist treatment reduces dopamine D1 receptor-mediated rotational behavior but not L-DOPA-induced abnormal involuntary movements in the unilateral dopamine-depleted rat.
Neuropharmacology 2006;50(6):761-8.
2006: Luis R Gardell; Tamara King; Michael H Ossipov; Kenner C Rice; Josephine Lai; Todd W Vanderah; Frank Porreca
Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery.
Neuroscience letters 2006;396(1):44-9.
2006: Elisabeth Greiner; Terrence L Boos; Thomas E Prisinzano; Maria G De Martino; Brian Zeglis; Christina M Dersch; Jamila Marcus; John S Partilla; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity.
Journal of medicinal chemistry 2006;49(5):1766-72.
2006: Emily Jutkiewicz; Mary M Torregrossa; Katarzyna Sobczyk-Kojiro; Henry I Mosberg; John E Folk; Kenner C Rice; Stanley J Watson Jr; James H Woods
Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects.
European journal of pharmacology 2006;531(1-3):151-9.
2006: Huina Zhang; Mary M Torregrossa; Emily Jutkiewicz; Yong-Gong Shi; Kenner C Rice; James H Woods; Stanley J Watson Jr; Mei-Chuan Ko
Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects.
The European journal of neuroscience 2006;23(4):984-94.
2006: William E Fantegrossi; A W Harrington; Christina Lynn Kiessel; Justin R Eckler; Richard A Rabin; Jerrold C Winter; Andrew Coop; Kenner C Rice; James H Woods
Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats.
Pharmacology, biochemistry, and behavior 2006;83(1):122-9.
2005: Kevin B Freeman; Kenner C Rice; Anthony L Riley
Assessment of monoamine transporter inhibition in the mediation of cocaine-induced conditioned taste aversion.
Pharmacology, biochemistry, and behavior 2005;82(3):583-9.
2005: ricardo gomez; Diana Caballero-Hernández; Reyes S Tamez-Guerra; Cristina Rodríguez Padilla; Patricia Tamez-Guerra; Kenner C Rice; Mary E Hicks; Richard J. Weber
Increased survival of tumor-bearing mice by the delta opioid SNC 80.
Anticancer research 2005;25(6C):4563-7.
2005: Mary M Torregrossa; John E Folk; Kenner C Rice; Stanley J Watson Jr; James H Woods
Chronic administration of the delta opioid receptor agonist (+)BW373U86 and antidepressants on behavior in the forced swim test and BDNF mRNA expression in rats.
Psychopharmacology 2005;183(1):31-40.
2005: Emily Jutkiewicz; Kenner C Rice; John R Traynor; James H Woods
Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats.
Psychopharmacology 2005;182(4):588-96.
2005: Emily Jutkiewicz; Sarah T Kaminsky; Kenner C Rice; John R Traynor; James H Woods
Differential behavioral tolerance to the delta-opioid agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley rats.
The Journal of pharmacology and experimental therapeutics 2005;315(1):414-22.
2005: Agnieszka Sulima; Thomas E Prisinzano; Thomas Spande; Jeffrey Deschamps; Noel Whittaker; Zeev Hochberg; Arthur E Jacobson; Kenner C Rice
A concise method for the preparation of deuterium-labeled cortisone: synthesis of [6,7-2H]cortisone.
Steroids 2005;70(11):763-9.
2005: William E Fantegrossi; Andrew W Harrington; Justin R Eckler; Sadia Arshad; Richard A Rabin; Jerrold C Winter; Andrew Coop; Kenner C Rice; James H Woods
Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats.
Psychopharmacology 2005;181(3):496-503.
2005: Jerrold C Winter; Artur K Kieres; M D Zimmerman; Chad J Reissig; Justin R Eckler; T Ullrich; Kenner C Rice; Richard A Rabin; Jerry B Richards
The stimulus properties of LSD in C57BL/6 mice.
Pharmacology, biochemistry, and behavior 2005;81(4):830-7.
2005: Barbara Nightingale; Christina M Dersch; Terrence L Boos; Elisabeth Greiner; William J Calhoun; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
Studies of the biogenic amine transporters. XI. Identification of a 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR12909) analog that allosterically modulates the serotonin transporter.
The Journal of pharmacology and experimental therapeutics 2005;314(2):906-15.
2005: Jerrold C Winter; Justin R Eckler; Kenner C Rice; Richard A Rabin
Serotonergic/glutamatergic interactions: potentiation of phencyclidine-induced stimulus control by citalopram.
Pharmacology, biochemistry, and behavior 2005;81(3):694-700.
2005: Diana Caballero-Hernández; Richard J. Weber; Mary E Hicks; Reyes S Tamez-Guerra; Cristina Rodríguez Padilla; Patricia Tamez-Guerra; Kenner C Rice; Subramaniam Ananthan; ricardo gomez
Potentiation of rat lymphocyte proliferation by novel non-peptidic synthetic opioids.
International immunopharmacology 2005;5(7-8):1271-8.
2005: Chaim Pick; Yakov Chernes; Tova Rigai; Kenner C Rice; Shaul Schreiber
The antinociceptive effect of zolpidem and zopiclone in mice.
Pharmacology, biochemistry, and behavior 2005;81(3):417-23.
2005: Glenn W Stevenson; John E Folk; Kenner C Rice; S Stevens Negus
Interactions between delta and mu opioid agonists in assays of schedule-controlled responding, thermal nociception, drug self-administration, and drug versus food choice in rhesus monkeys: studies with SNC80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and heroin.
The Journal of pharmacology and experimental therapeutics 2005;314(1):221-31.
2005: Emily Jutkiewicz; Susan K Wood; Hani Houshyar; Ling-Wei Hsin; Kenner C Rice; James H Woods
The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats.
Psychopharmacology 2005;180(2):215-23.
2005: Huifang Wu; Linn N Thatcher; Denzil Bernard; Damon Parrish; Jeffrey Deschamps; Kenner C Rice; Alexander D. Mackerell; Andrew Coop
Position of coordination of the lithium ion determines the regioselectivity of demethylations of 3,4-dimethoxymorphinans with L-selectride.
Organic letters 2005;7(13):2531-4.
2005: Erin C Stoffel; Catherine Ulibarri; John E Folk; Kenner C Rice; Rebecca M Craft
Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats.
The journal of pain : official journal of the American Pain Society 2005;6(4):261-74.
2005: David V Herin; Shijing Liu; Thomas Ullrich; Kenner C Rice; Kathryn A Cunningham
Role of the serotonin 5-HT2A receptor in the hyperlocomotive and hyperthermic effects of (+)-3,4-methylenedioxymethamphetamine.
Psychopharmacology 2005;178(4):505-13.
2005: Emily Jutkiewicz; Nicholas P Walker; John E Folk; Kenner C Rice; Philip S Portoghese; James H Woods; John R Traynor
Comparison of peptidic and nonpeptidic delta-opioid agonists on guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding in brain slices from Sprague-Dawley rats.
The Journal of pharmacology and experimental therapeutics 2005;312(3):1314-20.
2005: Jian-Kang Jiang; Craig J Thomas; Susanne Neumann; Xinping Lu; Kenner C Rice; Marvin C Gershengorn
1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors.
Bioorganic & medicinal chemistry letters 2005;15(3):733-6.
2004: Alejandro Ayala; Judy G Pushkas; J Dee Higley; Donna S Ronsaville; Philip W Gold; George Chrousos; Karel Pacak; Karim A Calis; Melissa Gerald; Stephen G Lindell; Kenner C Rice; Giovanni Cizza
Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotropin-releasing hormone receptor antagonist in a primate stress paradigm.
The Journal of clinical endocrinology and metabolism 2004;89(11):5729-37.
2004: In Jong Kim; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans.
Bioorganic & medicinal chemistry 2004;12(16):4543-50.
2004: Akihiro Hashimoto; Anna K Przybyl; Joannes T M Linders; Shinichi Kodato; Xinrong Tian; Jeffrey Deschamps; Clifford George; Judith L Flippen-Anderson; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor-mediated phenomena. 33. Construction of a strained trans-5,6-ring system by displacement of a nitro-activated aromatic fluorine. synthesis of the penultimate oxide-bridged phenylmorphans.
The Journal of organic chemistry 2004;69(16):5322-7.
2004: Christopher Bishop; Jennifer L Tessmer; Thomas Ullrich; Kenner C Rice; Paul D Walker
Serotonin 5-HT2A receptors underlie increased motor behaviors induced in dopamine-depleted rats by intrastriatal 5-HT2A/2C agonism.
The Journal of pharmacology and experimental therapeutics 2004;310(2):687-94.
2004: William Eckelman; Kenner C Rice; Carlo Contoreggi
New tools to monitor stress using non-invasive PET imaging.
Annals of the New York Academy of Sciences 2004;1018():487-94.
2004: Jillian H Broadbear; Gail Winger; Jean E Rivier; Kenner C Rice; James H Woods
Corticotropin-releasing hormone antagonists, astressin B and antalarmin: differing profiles of activity in rhesus monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(6):1112-21.
2004: Kimberly P Lindsey; Kristin M Wilcox; John R Votaw; Mark M Goodman; Christophe Plisson; Frank carroll; Kenner C Rice; Leonard L Howell
Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging.
The Journal of pharmacology and experimental therapeutics 2004;309(3):959-69.
2004: Han Yu; In Jong Kim; John E Folk; Xinrong Tian; Richard B Rothman; Michael H Baumann; Christina M Dersch; Judith L Flippen-Anderson; Damon Parrish; Arthur E Jacobson; Kenner C Rice
Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.
Journal of medicinal chemistry 2004;47(10):2624-34.
2004: William E Fantegrossi; Christina Lynn Kiessel; P Tarn Leach; C Van Martin; Rachel Lynn Karabenick; X Chen; Y Ohizumi; Thomas Ullrich; Kenner C Rice; James H Woods
Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice.
Psychopharmacology 2004;173(3-4):270-7.
2004: Emily Jutkiewicz; Erik B Eller; John E Folk; Kenner C Rice; John R Traynor; James H Woods
Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats.
The Journal of pharmacology and experimental therapeutics 2004;309(1):173-81.
2004: Mary M Torregrossa; Ceylan Isgor; John E Folk; Kenner C Rice; Stanley J Watson Jr; James H Woods
The delta-opioid receptor agonist (+)BW373U86 regulates BDNF mRNA expression in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(4):649-59.
2004: Shinichi Kodato; Joannes T M Linders; Xiao-Hui Gu; Koichiro Yamada; Judith L Flippen-Anderson; Jeffrey Deschamps; Arthur E Jacobson; Kenner C Rice
Synthesis of rac-(1R,4aR,9aR)-2-methyl-1,3,4,9a-tetrahydro-2H-1,4a-propanobenzofuro[2,3-c]pyridin-6-ol. An unusual double rearrangement leading to the ortho- and para-f oxide-bridged phenylmorphan isomers.
Organic & biomolecular chemistry 2004;2(3):330-6.
2004: Chad M Thompson; Heidi Wojno; Elisabeth Greiner; Everette L May; Kenner C Rice; Dana E Selley
Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors.
The Journal of pharmacology and experimental therapeutics 2004;308(2):547-54.
2004: Elisabeth Greiner; John E Folk; Arthur E Jacobson; Kenner C Rice
A novel and facile preparation of bremazocine enantiomers through optically pure N-norbremazocines.
Bioorganic & medicinal chemistry 2004;12(1):233-8.
2004: Carlo Contoreggi; Kenner C Rice; George Chrousos
Nonpeptide corticotropin-releasing hormone receptor type 1 antagonists and their applications in psychosomatic disorders.
Neuroendocrinology 2004;80(2):111-23.
2003: Glenn W Stevenson; John E Folk; David C Linsenmayer; Kenner C Rice; S Stevens Negus
Opioid interactions in rhesus monkeys: effects of delta + mu and delta + kappa agonists on schedule-controlled responding and thermal nociception.
The Journal of pharmacology and experimental therapeutics 2003;307(3):1054-64.
2003: Richard B Rothman; Subramaniam Jayanthi; Xiaoying Wang; Christina M Dersch; Jean Lud Cadet; Thomas E Prisinzano; Kenner C Rice; Michael H Baumann
High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain.
Synapse (New York, N.Y.) 2003;50(3):233-9.
2003: In Jong Kim; Thomas Ullrich; James Janetka; M Scott Furness; Arthur E Jacobson; Richard B Rothman; Christina M Dersch; Judith L Flippen-Anderson; Clifford George; Kenner C Rice
Diaryldimethylpiperazine ligands with mu- and delta-opioid receptor affinity: Synthesis of (+)-4-[(alphaR)-alpha-(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide and (-)-4-[(alphaR)-alpha-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide.
Bioorganic & medicinal chemistry 2003;11(22):4761-8.
2003: Emily Jutkiewicz; Kenner C Rice; James H Woods; P J Winsauer
Effects of the delta-opioid receptor agonist SNC80 on learning relative to its antidepressant-like effects in rats.
Behavioural pharmacology 2003;14(7):509-16.
2003: Elaine M Jagoda; Carlo Contoreggi; Mei-Jing Lee; Chih-Hao K Kao; Lawrence P Szajek; Samuel J Listwak; Philip Gold; George Chrousos; Elisabeth Greiner; B Moon Kim; Arthur E Jacobson; Kenner C Rice; William Eckelman
Autoradiographic visualization of corticotropin releasing hormone type 1 receptors with a nonpeptide ligand: synthesis of [(76)Br]MJL-1-109-2.
Journal of medicinal chemistry 2003;46(17):3559-62.
2003: Eva V Varga; Marc K Rubenzik; Dagmar Stropova; Masano Sugiyama; Vanessa Grife; Victor J Hruby; Kenner C Rice; William R Roeske; Henry I Yamamura
Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment.
The Journal of pharmacology and experimental therapeutics 2003;306(1):109-15.
2003: James Janetka; M Scott Furness; Xiaoyan Zhang; Andrew Coop; John E Folk; Mariena V Mattson; Arthur E Jacobson; Kenner C Rice
Enantioconvergent synthesis of (-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine, an intermediate to delta-opioid receptor ligands.
The Journal of organic chemistry 2003;68(10):3976-80.
2003: Elisabeth Greiner; Thomas E Prisinzano; Edward M Johnson; Christina M Dersch; Jamila Marcus; John S Partilla; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.
Journal of medicinal chemistry 2003;46(8):1465-9.
2003: David Lewis; Ying Zhang; Thomas E Prisinzano; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.
Bioorganic & medicinal chemistry letters 2003;13(7):1385-9.
2003: Anna K Przybyl; Judith L Flippen-Anderson; Arthur E Jacobson; Kenner C Rice
Practical and high-yield syntheses of dihydromorphine from tetrahydrothebaine and efficient syntheses of (8S)-8-bromomorphide.
The Journal of organic chemistry 2003;68(5):2010-3.
2003: William E Fantegrossi; Tomek Godlewski; Rachel L Karabenick; Jermaine M Stephens; Thomas Ullrich; Kenner C Rice; James H Woods
Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice.
Psychopharmacology 2003;166(3):202-11.
2003: Ling-Wei Hsin; Thomas E Prisinzano; Chavon R Wilkerson; Christina M Dersch; Robert Horel; Arthur E Jacobson; Richard B Rothman; Kenner C Rice
Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.
Bioorganic & medicinal chemistry letters 2003;13(3):553-6.
2003: Iván Ordaz-Sánchez; Richard J. Weber; Kenner C Rice; Xiaoyan Zhang; Cristina Rodríguez Padilla; Reyes S Tamez-Guerra; José L Méndez-Vázquez; R Gómez-Flores
Chemotaxis of human and rat leukocytes by the delta-selective non-peptidic opioid SNC 80.
Revista latinoamericana de microbiología 2003;45(1-2):16-23.
2002: Jillian H Broadbear; Gail Winger; Kenner C Rice; James H Woods
Antalarmin, a putative CRH-RI antagonist, has transient reinforcing effects in rhesus monkeys.
Psychopharmacology 2002;164(3):268-76.
2002: S Stevens Negus; J M Bidlack; Nancy K Mello; MS Furness; Kenner C Rice; Michael R Brandt
Delta opioid antagonist effects of buprenorphine in rhesus monkeys.
Behavioural pharmacology 2002;13(7):557-70.
2002: Daniel C Broom; Joshua F Nitsche; John E Pintar; Kenner C Rice; James H Woods; John R Traynor
Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice.
The Journal of pharmacology and experimental therapeutics 2002;303(2):723-9.
2002: Linda A Dykstra; Arthur L Granger; Richard M Allen; Xiaoyan Zhang; Kenner C Rice
Antinociceptive effects of the selective delta opioid agonist SNC80 alone and in combination with mu opioids in the squirrel monkey titration procedure.
Psychopharmacology 2002;163(3-4):420-9.
2002: Daniel C Broom; Emily Jutkiewicz; John E Folk; John R Traynor; Kenner C Rice; James H Woods
Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats.
Psychopharmacology 2002;164(1):42-8.
2002: Akihiro Hashimoto; Arthur E Jacobson; Richard B Rothman; Christina M Dersch; Clifford George; Judith L Flippen-Anderson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. Part 28: new opioid antagonists from enantiomeric analogues of 5-(3-hydroxyphenyl)-N-phenylethylmorphan.
Bioorganic & medicinal chemistry 2002;10(10):3319-29.
2002: Thomas E Prisinzano; Elisabeth Greiner; Edward M Johnson; Christina M Dersch; Jamila Marcus; John S Partilla; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter.
Journal of medicinal chemistry 2002;45(19):4371-4.
2002: Bryan L Roth; Karen Baner; Richard B Westkaemper; Daniel Siebert; Kenner C Rice; SeAnna Steinberg; Paul Ernsberger; Richard B Rothman
Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11934-9.
2002: Daniel C Broom; Emily Jutkiewicz; Kenner C Rice; John R Traynor; James H Woods
Behavioral effects of delta-opioid receptor agonists: potential antidepressants?
Japanese journal of pharmacology 2002;90(1):1-6.
2002: Michael H Baumann; Jennifer M Phillips; Mario A Ayestas; Syed F Ali; Kenner C Rice; Richard B Rothman
Preclinical evaluation of GBR12909 decanoate as a long-acting medication for methamphetamine dependence.
Annals of the New York Academy of Sciences 2002;965():92-108.
2002: William E Fantegrossi; Thomas Ullrich; Kenner C Rice; James H Woods; Gail Winger
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serotonergic involvement.
Psychopharmacology 2002;161(4):356-64.
2002: Elizabeth Webster; Ruth M Barrientos; Carlo Contoreggi; Mitchel G Isaac; Sophie Ligier; K Eddie Gabry; George Chrousos; Edward F McCarthy; Kenner C Rice; Philip W Gold; Esther M Sternberg
Corticotropin releasing hormone (CRH) antagonist attenuates adjuvant induced arthritis: role of CRH in peripheral inflammation.
The Journal of rheumatology 2002;29(6):1252-61.
2002: Michael H Baumann; Mario A Ayestas; Lawrence G Sharpe; David B Lewis; Kenner C Rice; Richard B Rothman
Persistent antagonism of methamphetamine-induced dopamine release in rats pretreated with GBR12909 decanoate.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1190-7.
2002: Daniel C Broom; Emily Jutkiewicz; John E Folk; John R Traynor; Kenner C Rice; James H Woods
Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(6):744-55.
2002: Richard B Rothman; Frank carroll; Marisela Morales; Daniel L Rowley; Kenner C Rice; Christina M Dersch; David M Donovan
Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice.
Synapse (New York, N.Y.) 2002;44(2):94-105.
2002: Ling-Wei Hsin; Christina M Dersch; Michael H Baumann; David Stafford; John R Glowa; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.
Journal of medicinal chemistry 2002;45(6):1321-9.
2002: Mei-Chuan Ko; Norah N Naughton; John R Traynor; Michael S Song; James H Woods; Kenner C Rice; A T McKnight
Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors.
British journal of pharmacology 2002;135(4):943-50.
2002: Han Yu; Thomas E Prisinzano; Christina M Dersch; Jamila Marcus; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives.
Bioorganic & medicinal chemistry letters 2002;12(2):165-8.
2002: K Eddie Gabry; George Chrousos; Kenner C Rice; R M Mostafa; Esther M Sternberg; Andre B Negrao; Elizabeth Webster; Samuel M McCann; Philip W Gold
Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs.
Molecular psychiatry 2002;7(5):474-83, 433.
2002: Glenn W Stevenson; Fernando Cañadas; Maria A Gomez-Serrano; Thomas Ullrich; Xiaoyan Zhang; Kenner C Rice; Anthony L Riley
Delta opioid discrimination learning in the rat: assessment with the selective delta agonist SNC80.
Pharmacology, biochemistry, and behavior 2002;71(1-2):283-92.
2002: Ling-Wei Hsin; Xinrong Tian; Elizabeth Webster; Andrew Coop; Timothy M Caldwell; Arthur E Jacobson; George Chrousos; Philip W Gold; Kamal E Habib; Alejandro Ayala; William Eckelman; Carlo Contoreggi; Kenner C Rice
CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists.
Bioorganic & medicinal chemistry 2002;10(1):175-83.
2001: Rebecca M Craft; Alan H Tseng; D M McNiel; M S Furness; Kenner C Rice
Receptor-selective antagonism of opioid antinociception in female versus male rats.
Behavioural pharmacology 2001;12(8):591-602.
2001: Ying Zhang; D B Joseph; Wayne D Bowen; Judith L Flippen-Anderson; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues.
Journal of medicinal chemistry 2001;44(23):3937-45.
2001: Thomas Ullrich; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Derivatives of 17-(2-methylallyl)-substituted noroxymorphone: variation of the delta address and its effects on affinity and selectivity for the delta opioid receptor.
Bioorganic & medicinal chemistry letters 2001;11(21):2883-5.
2001: Michael R Brandt; MS Furness; Kenner C Rice; B D Fischer; S Stevens Negus
Studies of tolerance and dependence with the delta-opioid agonist SNC80 in rhesus monkeys responding under a schedule of food presentation.
The Journal of pharmacology and experimental therapeutics 2001;299(2):629-37.
2001: Irina Fedorova; A Hashimoto; Robert A Fecik; Michael P Hedrick; LO Hanus; Dale L Boger; Kenner C Rice; Anthony Basile
Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems.
The Journal of pharmacology and experimental therapeutics 2001;299(1):332-42.
2001: Heng Xu; Yi-Feng Lu; Kenner C Rice; Subramaniam Ananthan; Richard B Rothman
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
Brain research bulletin 2001;55(4):507-11.
2001: Heng Xu; Yi-Feng Lu; J B Thomas; Frank carroll; Kenner C Rice; Richard B Rothman
Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human delta-opioid receptor.
Synapse (New York, N.Y.) 2001;40(4):269-74.
2001: ricardo gomez; Kenner C Rice; X Zhang; Richard J. Weber
Increased tumor necrosis factor-alpha and nitric oxide production by rat macrophages following in vitro stimulation and intravenous administration of the delta-opioid agonist SNC 80.
Life sciences 2001;68(24):2675-84.
2001: S McLamore; Thomas Ullrich; Richard B Rothman; HAN XU; Christina M Dersch; Andrew Coop; P Davis; F Porreca; Arthur E Jacobson; Kenner C Rice
Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.
Journal of medicinal chemistry 2001;44(9):1471-4.
2001: Yoshiaki Hosohata; Eva V Varga; Dagmar Stropova; X Li; Richard J Knapp; Victor J Hruby; Kenner C Rice; Hiroshi Nagase; William R Roeske; Henry I Yamamura
Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation.
Life sciences 2001;68(19-20):2233-42.
2001: Michael R Brandt; MS Furness; Nancy K Mello; Kenner C Rice; S Stevens Negus
Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity.
The Journal of pharmacology and experimental therapeutics 2001;296(3):939-46.
2001: David Stafford; Mark G LeSage; Kenner C Rice; John R Glowa
A comparison of cocaine, GBR 12909, and phentermine self-administration by rhesus monkeys on a progressive-ratio schedule.
Drug and alcohol dependence 2001;62(1):41-7.
2001: Xinrong Tian; Ling-Wei Hsin; Elizabeth Webster; Carlo Contoreggi; George Chrousos; Philip W Gold; Kamal E Habib; Alejandro Ayala; William Eckelman; Arthur E Jacobson; Kenner C Rice
The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type.
Bioorganic & medicinal chemistry letters 2001;11(3):331-3.
2001: Heng Xu; A Hashimoto; Kenner C Rice; Arthur E Jacobson; J B Thomas; Frank carroll; J Lai; Richard B Rothman
Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay.
Synapse (New York, N.Y.) 2001;39(1):64-9.
2001: Richard B Rothman; Michael H Baumann; Christina M Dersch; D V Romero; Kenner C Rice; Frank carroll; John S Partilla
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.
Synapse (New York, N.Y.) 2001;39(1):32-41.
2000: Xiao-Hui Gu; Han Yu; Arthur E Jacobson; Richard B Rothman; Christina M Dersch; C George; Judith L Flippen-Anderson; Kenner C Rice
Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline.
Journal of medicinal chemistry 2000;43(25):4868-76.
2000: Ying Zhang; Richard B Rothman; Christina M Dersch; B R de Costa; Arthur E Jacobson; Kenner C Rice
Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909).
Journal of medicinal chemistry 2000;43(25):4840-9.
2000: John S Partilla; Christina M Dersch; H Yu; Kenner C Rice; Richard B Rothman
Neurochemical neutralization of amphetamine-type stimulants in rat brain by the indatraline analog (-)-HY038.
Brain research bulletin 2000;53(6):821-6.
2000: Han Yu; Richard B Rothman; Christina M Dersch; John S Partilla; Kenner C Rice
Uptake and release effects of diethylpropion and its metabolites with biogenic amine transporters.
Bioorganic & medicinal chemistry 2000;8(12):2689-92.
2000: Mitchel A Kling; Richard E Carson; Lisa Borg; Alan J Zametkin; John A Matochik; James H Schluger; Peter Herscovitch; Kenner C Rice; Ann Ho; William Eckelman; Mary Jeanne Kreek
Opioid receptor imaging with positron emission tomography and [(18)F]cyclofoxy in long-term, methadone-treated former heroin addicts.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1070-6.
2000: Andrew Coop; Arthur E Jacobson; Mario D Aceto; Louis S Harris; John R Traynor; James H Woods; Kenner C Rice
N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole.
Bioorganic & medicinal chemistry letters 2000;10(21):2449-51.
2000: David Stafford; Kenner C Rice; D B Lewis; John R Glowa
Response requirements and unit dose modify the effects of GBR 12909 on cocaine-maintained behavior.
Experimental and clinical psychopharmacology 2000;8(4):539-48.
2000: RJ Briscoe; C L Cabrera; TJ Baird; Kenner C Rice; James H Woods
Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats.
Brain research 2000;881(2):204-7.
2000: Thomas Ullrich; Kenner C Rice
A practical synthesis of the serotonin 5-HT2A receptor antagonist MDL 100907, its enantiomer and their 3-phenolic derivatives as precursors for [11C]labeled PET ligands.
Bioorganic & medicinal chemistry 2000;8(10):2427-32.
2000: Richard B Rothman; John S Partilla; Christina M Dersch; Frank carroll; Kenner C Rice; Michael H Baumann
Methamphetamine dependence: medication development efforts based on the dual deficit model of stimulant addiction.
Annals of the New York Academy of Sciences 2000;914():71-81.
2000: M Scott Furness; Xiaoyan Zhang; Andrew Coop; Arthur E Jacobson; Richard B Rothman; Christina M Dersch; HAN XU; F Porreca; Kenner C Rice
Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers.
Journal of medicinal chemistry 2000;43(16):3193-6.
2000: Glenn W Stevenson; F Cañadas; Xiaoyan Zhang; Kenner C Rice; Anthony L Riley
Morphine discriminative control is mediated by the mu opioid receptor: assessment of delta opioid substitution and antagonism.
Pharmacology, biochemistry, and behavior 2000;66(4):851-6.
2000: A C Hutchinson; Gregory R Simpson; J F Randall; Xiaoyan Zhang; S N Calderon; Kenner C Rice; Anthony L Riley
Assessment of SNC 80 and naltrindole within a conditioned taste aversion design.
Pharmacology, biochemistry, and behavior 2000;66(4):779-87.
2000: Kamal E Habib; Katherine P Weld; Kenner C Rice; Judy G Pushkas; Maribeth Champoux; Samuel J Listwak; Elizabeth Webster; A J Atkinson; Jay Schulkin; Carlo Contoreggi; George Chrousos; Samuel M McCann; Stephen J Suomi; J Dee Higley; Philip W Gold
Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):6079-84.
2000: Michael H Baumann; Mario A Ayestas; Christina M Dersch; A Brockington; Kenner C Rice; Richard B Rothman
Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: therapeutic implications.
Synapse (New York, N.Y.) 2000;36(2):102-13.
2000: Ling-Wei Hsin; Elizabeth Webster; George Chrousos; Philip W Gold; William Eckelman; Carlo Contoreggi; Kenner C Rice
Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: the development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor.
Bioorganic & medicinal chemistry letters 2000;10(8):707-10.
2000: Richard B Rothman; John S Partilla; Michael H Baumann; Christina M Dersch; Frank carroll; Kenner C Rice
Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse.
Synapse (New York, N.Y.) 2000;35(3):222-7.
2000: Yoshiaki Hosohata; Todd W Vanderah; TH Burkey; Michael H Ossipov; CJ Kovelowski; I Sora; George R. Uhl; X Zhang; Kenner C Rice; William R Roeske; Victor J Hruby; Henry I Yamamura; Josephine Lai; Frank Porreca
delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice.
European journal of pharmacology 2000;388(3):241-8.
2000: Ma-Li Wong; Mitchel A Kling; P J Munson; Samuel J Listwak; Julio Licinio; P Prolo; BI Karp; I E McCutcheon; Thomas D Geracioti; Michael D DeBellis; Kenner C Rice; David S Goldstein; JD Veldhuis; George Chrousos; E H Oldfield; Samuel M McCann; Philip W Gold
Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):325-30.
1999: Xiaoyan Zhang; Kenner C Rice; SN Calderon; H Kayakiri; L Smith; Andrew Coop; Arthur E Jacobson; Richard B Rothman; P Davis; Christina M Dersch; F Porreca
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.
Journal of medicinal chemistry 1999;42(26):5455-63.
1999: Andrew Coop; J Pinto; L Wang; K McCullough; Richard B Rothman; Christina M Dersch; Arthur E Jacobson; Kenner C Rice
Delta opioid binding selectivity of 3-ether analogs of naltrindole.
Bioorganic & medicinal chemistry letters 1999;9(24):3435-8.
1999: SO Heyliger; C Jackson; Kenner C Rice; Richard B Rothman
Opioid peptide receptor studies. 10. Nor-BNI differentially inhibits kappa receptor agonist-induced G-protein activation in the guinea pig caudate: further evidence of kappa receptor heterogeneity.
Synapse (New York, N.Y.) 1999;34(4):256-65.
1999: D B Lewis; Dorota Matecka; Ying Zhang; Ling-Wei Hsin; Christina M Dersch; David Stafford; John R Glowa; Richard B Rothman; Kenner C Rice
Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.
Journal of medicinal chemistry 1999;42(24):5029-42.
1999: D V Romero; John S Partilla; Q X Zheng; SO Heyliger; Q Ni; Kenner C Rice; J Lai; Richard B Rothman
Opioid peptide receptor studies. 12. Buprenorphine is a potent and selective mu/kappa antagonist in the [35S]-GTP-gamma-S functional binding assay.
Synapse (New York, N.Y.) 1999;34(2):83-94.
1999: Subramaniam Ananthan; Hollis S Kezar; R L Carter; Surendra K Saini; Kenner C Rice; J L Wells; Peg Davis; Heng Xu; Christina M Dersch; Edward J Bilsky; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Journal of medicinal chemistry 1999;42(18):3527-38.
1999: Michael R Brandt; S Stevens Negus; Nancy K Mello; MS Furness; X Zhang; Kenner C Rice
Discriminative stimulus effects of the nonpeptidic delta-opioid agonist SNC80 in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1157-64.
1999: Andrew Coop; Richard B Rothman; Christina M Dersch; John S Partilla; F Porreca; P Davis; Arthur E Jacobson; Kenner C Rice
delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.
Journal of medicinal chemistry 1999;42(9):1673-9.
1999: Heng Xu; Yi-Feng Lu; John S Partilla; Q X Zheng; Jia Bei Wang; G A Brine; Frank carroll; Kenner C Rice; Kai-Xian Chen; Zhi-Qiang Chi; Richard B Rothman
Opioid peptide receptor studies, 11: involvement of Tyr148, Trp318 and His319 of the rat mu-opioid receptor in binding of mu-selective ligands.
Synapse (New York, N.Y.) 1999;32(1):23-8.
1999: F H Wojnicki; Richard B Rothman; Kenner C Rice; John R Glowa
Effects of phentermine on responding maintained under multiple fixed-ratio schedules of food and cocaine presentation in the rhesus monkey.
The Journal of pharmacology and experimental therapeutics 1999;288(2):550-60.
1999: Mario D Aceto; Louis S Harris; M E Abood; Kenner C Rice
Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine.
European journal of pharmacology 1999;365(2-3):143-7.
1999: Ma-Li Wong; Elizabeth Webster; H Spokes; P Phu; Monika Ehrhart-Bornstein; Stefan R Bornstein; C S Park; Kenner C Rice; George Chrousos; Julio Licinio; Philip W Gold
Chronic administration of the non-peptide CRH type 1 receptor antagonist antalarmin does not blunt hypothalamic-pituitary-adrenal axis responses to acute immobilization stress.
Life sciences 1999;65(4):PL53-8.
1998: Ying Zhang; Wanda Williams; C Torrence-Campbell; Wayne D Bowen; Kenner C Rice
Characterization of novel N,N'-disubstituted piperazines as sigma receptor ligands.
Journal of medicinal chemistry 1998;41(25):4950-7.
1998: J E Nowak; ricardo gomez; S N Calderon; Kenner C Rice; Richard J. Weber
Rat natural killer cell, T cell and macrophage functions after intracerebroventricular injection of SNC 80.
The Journal of pharmacology and experimental therapeutics 1998;286(2):931-7.
1998: Subramaniam Ananthan; Cheryl A Johnson; R L Carter; S D Clayton; Kenner C Rice; Heng Xu; Peg Davis; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
Journal of medicinal chemistry 1998;41(15):2872-81.
1998: H Kubota; Richard B Rothman; Christina M Dersch; K McCullough; J Pinto; Kenner C Rice
Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Bioorganic & medicinal chemistry letters 1998;8(7):799-804.
1998: Stefan R Bornstein; Elizabeth Webster; David Torpy; S J Richman; N Mitsiades; M Igel; D B Lewis; Kenner C Rice; Hans-Georg Joost; M Tsokos; George Chrousos
Chronic effects of a nonpeptide corticotropin-releasing hormone type I receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation.
Endocrinology 1998;139(4):1546-55.
1998: Richard B Rothman; M L Silverthorn; John R Glowa; Dorota Matecka; Kenner C Rice; Frank carroll; John S Partilla; George R. Uhl; David J Vandenbergh; Christina M Dersch
Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate.
Synapse (New York, N.Y.) 1998;28(4):322-38.
1998: Yi-Feng Lu; Heng Xu; L Y Liu-Chen; C Chen; John S Partilla; G A Brine; Frank carroll; Kenner C Rice; J Lai; Frank Porreca; W Sadee; Richard B Rothman
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
Synapse (New York, N.Y.) 1998;28(2):117-24.
1998: Q Ni; Heng Xu; John S Partilla; Kenner C Rice; Dorota Matecka; S N Calderon; Frank Porreca; J Lai; Helmut Schmidhammer; Roland Krassnig; Richard B Rothman
Opioid peptide receptor studies. 9. Identification of a novel non-mu- non-delta-like opioid peptide binding site in rat brain.
Peptides 1998;19(6):1079-90.
1998: Heng Xu; Yi-Feng Lu; John S Partilla; J Pinto; S N Calderon; Dorota Matecka; Kenner C Rice; J Lai; Frank Porreca; Subramaniam Ananthan; Richard B Rothman
Opioid peptide receptor studies. 8. One of the mouse brain deltaNCX binding sites is similar to the cloned mouse opioid delta receptor: further evidence for heterogeneity of delta opioid receptors.
Peptides 1998;19(2):343-50.
1997: Y Katsura; Xiaoyan Zhang; K Homma; Kenner C Rice; SN Calderon; Richard B Rothman; Henry I Yamamura; P Davis; Judith L Flippen-Anderson; HAN XU; K Becketts; E J Foltz; F Porreca
Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.
Journal of medicinal chemistry 1997;40(18):2936-47.
1997: Raymond M Quock; Yoshiaki Hosohata; Richard J Knapp; TH Burkey; Keiko Hosohata; X Zhang; Kenner C Rice; Hiroshi Nagase; Victor J Hruby; Frank Porreca; William R Roeske; Henry I Yamamura
Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor.
European journal of pharmacology 1997;326(1):101-4.
1997: John R Glowa; Kenner C Rice; Dorota Matecka; Richard B Rothman
Phentermine/fenfluramine decreases cocaine self-administration in rhesus monkeys.
Neuroreport 1997;8(6):1347-51.
1997: Dorota Matecka; David Lewis; Richard B Rothman; Christina M Dersch; F H Wojnicki; John R Glowa; AC DeVries; A Pert; Kenner C Rice
Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.
Journal of medicinal chemistry 1997;40(5):705-16.
1997: SN Calderon; Kenner C Rice; Richard B Rothman; F Porreca; Judith L Flippen-Anderson; H Kayakiri; HAN XU; K Becketts; L E Smith; E J Bilsky; P Davis; R Horvath
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands.
Journal of medicinal chemistry 1997;40(5):695-704.
1996: Elizabeth Webster; D B Lewis; David Torpy; E K Zachman; Kenner C Rice; George Chrousos
In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation.
Endocrinology 1996;137(12):5747-50.
1996: Dorota Matecka; Richard B Rothman; L Radesca; B R de Costa; Christina M Dersch; John S Partilla; A Pert; John R Glowa; F H Wojnicki; Kenner C Rice
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).
Journal of medicinal chemistry 1996;39(24):4704-16.
1996: John R Glowa; W E Fantegrossi; D B Lewis; Dorota Matecka; Kenner C Rice; Richard B Rothman
Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, a long-acting ester derivative of GBR 12909.
Journal of medicinal chemistry 1996;39(24):4689-91.
1996: Ying Zhang; Wanda Williams; Wayne D Bowen; Kenner C Rice
Synthesis and evaluation of aryl-substituted N-(arylethyl)-N-methyl-2-(1-pyrrolidinyl)ethylamines and corresponding arylacetamides for sigma receptor affinity.
Journal of medicinal chemistry 1996;39(18):3564-8.
1996: Richard J Knapp; G Santoro; I A De Leon; K B Lee; S A Edsall; Sue Waite; Ewa Malatynska; E Varga; SN Calderon; Kenner C Rice; Richard B Rothman; F Porreca; William R Roeske; Henry I Yamamura
Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1284-91.
1996: C M Bertha; M Ellis; Judith L Flippen-Anderson; F Porreca; Richard B Rothman; P Davis; HAN XU; K Becketts; Kenner C Rice
Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.
Journal of medicinal chemistry 1996;39(10):2081-6.
1996: K Yamada; Kenner C Rice; Judith L Flippen-Anderson; M A Eissenstat; Susan Ward; M R Johnson; Allyn C Howlett
(Aminoalkyl)indole isothiocyanates as potential electrophilic affinity ligands for the brain cannabinoid receptor.
Journal of medicinal chemistry 1996;39(10):1967-74.
1996: Gregory I Elmer; A Brockington; David A Gorelick; F I Carrol; Kenner C Rice; Dorota Matecka; Steven R Goldberg; Richard B Rothman
Cocaine cross-sensitization to dopamine uptake inhibitors: unique effects of GBR12909.
Pharmacology, biochemistry, and behavior 1996;53(4):911-8.
1995: C M Bertha; BJ Vilner; M V Mattson; Wayne D Bowen; K Becketts; HAN XU; Richard B Rothman; Judith L Flippen-Anderson; Kenner C Rice
(E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype.
Journal of medicinal chemistry 1995;38(24):4776-85.
1995: X Y Cha; Heng Xu; Q Ni; John S Partilla; Kenner C Rice; Dorota Matecka; S N Calderon; F Porreca; J Lai; Richard B Rothman
Opioid peptide receptor studies. 4. Antisense oligodeoxynucleotide to the delta opioid receptor delineates opioid receptor subtypes.
Regulatory peptides 1995;59(2):247-53.
1995: Richard B Rothman; Heng Xu; Jia Bei Wang; John S Partilla; H Kayakiri; Kenner C Rice; George R. Uhl
Ligand selectivity of cloned human and rat opioid mu receptors.
Synapse (New York, N.Y.) 1995;21(1):60-4.
1995: Richard B Rothman; M L Silverthorn; Michael H Baumann; Carl B Goodman; Jean Lud Cadet; Dorota Matecka; Kenner C Rice; Frank carroll; Jia Bei Wang; George R. Uhl
Studies of the biogenic amine transporters. VI. Characterization of a novel cocaine binding site, identified with [125I]RTI-55, in membranes prepared from whole rat brain minus caudate.
The Journal of pharmacology and experimental therapeutics 1995;274(1):385-95.
1995: Wayne D Bowen; C M Bertha; BJ Vilner; Kenner C Rice
CB-64D and CB-184: ligands with high sigma 2 receptor affinity and subtype selectivity.
European journal of pharmacology 1995;278(3):257-60.
1995: C M Bertha; Judith L Flippen-Anderson; Richard B Rothman; F Porreca; P Davis; HAN XU; K Becketts; X Y Cha; Kenner C Rice
Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.
Journal of medicinal chemistry 1995;38(9):1523-37.
1995: E J Bilsky; SN Calderon; T Wang; R N Bernstein; P Davis; Victor J Hruby; R W McNutt; Richard B Rothman; Kenner C Rice; F Porreca
SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist.
The Journal of pharmacology and experimental therapeutics 1995;273(1):359-66.
1995: M L Silverthorn; Christina M Dersch; Michael H Baumann; Jean Lud Cadet; John S Partilla; Kenner C Rice; Frank carroll; K M Becketts; A Brockington; Richard B Rothman
Studies of the biogenic amine transporters. V. Demonstration of two binding sites for the cocaine analog [125I]RTI-55 associated with the 5-HT transporter in rat brain membranes.
The Journal of pharmacology and experimental therapeutics 1995;273(1):213-22.
1995: Heng Xu; Carl B Goodman; John S Partilla; Q Ni; H Kayakiri; Kenner C Rice; Richard B Rothman
6 beta-[125iodo]-3, 14-dihydroxy-17-methyl-4, 5 alpha-epoxymorphinan ([125I]IOXY-AGO): a potent and selective radioligand for opioid mu receptors.
Synapse (New York, N.Y.) 1995;19(2):105-11.
1995: Q Ni; Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; H Kayakiri; Richard B Rothman
Opioid peptide receptor studies. 3. Interaction of opioid peptides and other drugs with four subtypes of the kappa 2 receptor in guinea pig brain.
Peptides 1995;16(6):1083-95.
1995: X Y Cha; Heng Xu; Kenner C Rice; F Porreca; J Lai; S Ananthan; Richard B Rothman
Opioid peptide receptor studies. 1. Identification of a novel delta-opioid receptor binding site in rat brain membranes.
Peptides 1995;16(2):191-8.
1994: Michael H Baumann; G U Char; B R De Costa; Kenner C Rice; Richard B Rothman
GBR12909 attenuates cocaine-induced activation of mesolimbic dopamine neurons in the rat.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1216-22.
1994: C M Bertha; M V Mattson; Judith L Flippen-Anderson; Richard B Rothman; HAN XU; X Y Cha; K Becketts; Kenner C Rice
A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands.
Journal of medicinal chemistry 1994;37(19):3163-70.
1994: J C Pinto; F Potié; Kenner C Rice; D Boring; M R Johnson; D M Evans; Gerald H Wilken; C H Cantrell; Allyn C Howlett
Cannabinoid receptor binding and agonist activity of amides and esters of arachidonic acid.
Molecular pharmacology 1994;46(3):516-22.
1994: Q Ni; Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Anna Borsodi; S Hosztafi; Richard B Rothman
Dihydrocodeinone-hydrazone, dihydrocodeinone-oxime, naloxone-3-OMe-oxime, and clocinnamox fail to irreversibly inhibit opioid kappa receptor binding.
Neurochemical research 1994;19(9):1159-63.
1994: SN Calderon; Richard B Rothman; F Porreca; Judith L Flippen-Anderson; R W McNutt; HAN XU; L E Smith; E J Bilsky; P Davis; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.
Journal of medicinal chemistry 1994;37(14):2125-8.
1994: Richard B Rothman; Jean Lud Cadet; H C Akunne; M L Silverthorn; Michael H Baumann; Frank carroll; Kenner C Rice; B R de Costa; John S Partilla; Jia Bei Wang
Studies of the biogenic amine transporters. IV. Demonstration of a multiplicity of binding sites in rat caudate membranes for the cocaine analog [125I]RTI-55.
The Journal of pharmacology and experimental therapeutics 1994;270(1):296-309.
1994: H C Akunne; J A Monn; A Thurkauf; Arthur E Jacobson; Kenner C Rice; J T Linders; Q Jiang; F Porreca; Richard B Rothman
An electrophilic affinity ligand based on (+)-MK801 distinguishes PCP site 1 from PCP site 2.
Neurochemical research 1994;19(4):385-9.
1994: H C Akunne; Christina M Dersch; Jean Lud Cadet; Michael H Baumann; G U Char; John S Partilla; B R de Costa; Kenner C Rice; Frank carroll; Richard B Rothman
Studies of the biogenic amine transporters. III. Demonstration of two binding sites for [3H]GBR12935 and [3H]BTCP in rat caudate membranes.
The Journal of pharmacology and experimental therapeutics 1994;268(3):1462-75.
1994: Christina M Dersch; H C Akunne; John S Partilla; G U Char; B R de Costa; Kenner C Rice; Frank carroll; Richard B Rothman
Studies of the biogenic amine transporters. 1. Dopamine reuptake blockers inhibit [3H]mazindol binding to the dopamine transporter by a competitive mechanism: preliminary evidence for different binding domains.
Neurochemical research 1994;19(2):201-8.
1993: Q Ni; Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Richard B Rothman
Selective labeling of kappa 2 opioid receptors in rat brain by [125I]IOXY: interaction of opioid peptides and other drugs with multiple kappa 2a binding sites.
Peptides 1993;14(6):1279-93.
1993: Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Richard B Rothman
Differential binding of opioid peptides and other drugs to two subtypes of opioid delta ncx binding sites in mouse brain: further evidence for delta receptor heterogeneity.
Peptides 1993;14(5):893-907.
1993: J T Linders; J A Monn; M V Mattson; C George; Arthur E Jacobson; Kenner C Rice
Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site.
Journal of medicinal chemistry 1993;36(17):2499-507.
1993: Richard B Rothman; B Lewis; Christina M Dersch; Heng Xu; L Radesca; B R de Costa; Kenner C Rice; R B Kilburn; H C Akunne; A Pert
Identification of a GBR12935 homolog, LR1111, which is over 4,000-fold selective for the dopamine transporter, relative to serotonin and norepinephrine transporters.
Synapse (New York, N.Y.) 1993;14(1):34-9.
1993: Z Q Gu; G Wong; C Dominguez; B R de Costa; Kenner C Rice; Phil Skolnick
Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.
Journal of medicinal chemistry 1993;36(8):1001-6.
1993: Richard B Rothman; K M Becketts; L R Radesca; B R de Costa; Kenner C Rice; Frank carroll; Christina M Dersch
Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists.
Life sciences 1993;53(17):PL267-72.
1993: Richard B Rothman; Heng Xu; G U Char; A Kim; B R De Costa; Kenner C Rice; D M Zimmerman
Phenylpiperidine opioid antagonists that promote weight loss in rats have high affinity for the kappa 2B (enkephalin-sensitive) binding site.
Peptides 1993;14(1):17-20.
1993: Richard E Carson; M A Channing; Ronald Blasberg; B B Dunn; R M Cohen; Kenner C Rice; Peter Herscovitch
Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(1):24-42.
1993: Wayne D Bowen; P J Tolentino; B N Kirschner; P Varghese; B R de Costa; Kenner C Rice
Sigma receptors and signal transduction: negative modulation of signaling through phosphoinositide-linked receptor systems.
NIDA research monograph 1993;133():69-93.
1992: Richard B Rothman; N Grieg; A Kim; B R De Costa; Kenner C Rice; Frank carroll; A Pert
Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter.
Pharmacology, biochemistry, and behavior 1992;43(4):1135-42.
1992: H C Akunne; B R de Costa; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
[3H] cocaine labels a binding site associated with the serotonin transporter in guinea pig brain: allosteric modulation by paroxetine.
Neurochemical research 1992;17(12):1275-83.
1992: Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Richard B Rothman
Interaction of opioid peptides and other drugs with multiple delta ncx binding sites in rat brain: further evidence for heterogeneity.
Peptides 1992;13(6):1207-13.
1992: Richard B Rothman; A Mahboubi; V Bykov; C H Kim; B R de Costa; Arthur E Jacobson; Kenner C Rice
Probing the opioid receptor complex with (+)-trans-SUPERFIT. II. Evidence that mu ligands are noncompetitive inhibitors of the delta cx opioid peptide binding site.
Peptides 1992;13(6):1137-43.
1992: Richard B Rothman; V Bykov; B G Xue; Heng Xu; B R De Costa; Arthur E Jacobson; Kenner C Rice; J E Kleinman; L S Brady
Interaction of opioid peptides and other drugs with multiple kappa receptors in rat and human brain. Evidence for species differences.
Peptides 1992;13(5):977-87.
1992: B R de Costa; Michael Iadarola; Richard B Rothman; K F Berman; C George; Amy Hauck Newman; A Mahboubi; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinan.
Journal of medicinal chemistry 1992;35(15):2826-35.
1992: Richard B Rothman; V Bykov; Arthur E Jacobson; Kenner C Rice; J E Long; W D Bowen
A study of the effect of the irreversible delta receptor antagonist [D-Ala2,Leu5,Cys6]-enkephalin on delta cx and delta ncx opioid binding sites in vitro and in vivo.
Peptides 1992;13(4):691-4.
1992: Wayne D Bowen; J Michael Walker; B R de Costa; R Wu; P J Tolentino; D Finn; R B Rothman; Kenner C Rice
Characterization of the enantiomers of cis-N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)cyclohexylamine (BD737 and BD738): novel compounds with high affinity, selectivity and biological efficacy at sigma receptors.
The Journal of pharmacology and experimental therapeutics 1992;262(1):32-40.
1992: A Thurkauf; M V Mattson; S Richardson; S Mirsadeghi; Paul Ornstein; E A Harrison; Kenner C Rice; Arthur E Jacobson; J A Monn
Analogues of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure-activity relationships.
Journal of medicinal chemistry 1992;35(8):1323-9.
1992: H C Akunne; J N Johannessen; B R de Costa; Kenner C Rice; Richard B Rothman
MPTP lesions of the nigrostriatal dopaminergic projection decrease [3H]1-[1-(2-thienyl)cyclohexyl]piperidine binding to PCP site 2: further evidence that PCP site 2 is associated with the biogenic amine reuptake complex.
Neurochemical research 1992;17(3):261-4.
1992: Arthur E Jacobson; J T Linders; Kenner C Rice; J A Monn; M V Mattson; C George
Three generations of electrophilic affinity ligands for the phencyclidine binding sites.
NIDA research monograph 1992;119():81-5.
1992: Amy Hauck Newman; Kenner C Rice; Arthur E Jacobson
Potent analgesia, respiratory depression, dependence, abuse liability-clue to separability.
NIDA research monograph 1992;119():54-8.
1992: Arthur E Jacobson; Kenner C Rice
The continuing interrelationship of CPDD and NIDDK.
NIDA research monograph 1992;119():49-53.
1992: Kenner C Rice
Opiate total synthesis and contemporary NIDDK analgesic research-natural and unnatural ligands for computed tomography imaging of receptors in conscious humans. Implications for future advances in the neurosciences.
NIDA research monograph 1992;119():91-5.
1992: B de Costa; Richard B Rothman; Wayne D Bowen; L Radesca; L Band; A Reid; L D Paolo; J M Walker; Arthur E Jacobson; Kenner C Rice
Novel kappa opioid receptor and sigma ligands.
NIDA research monograph 1992;119():76-80.
1991: Michael A Rogawski; S Yamaguchi; S M Jones; Kenner C Rice; A Thurkauf; J A Monn
Anticonvulsant activity of the low-affinity uncompetitive N-methyl-D- aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine (ADCI): comparison with the structural analogs dizocilpine (MK-801) and carbamazepine.
The Journal of pharmacology and experimental therapeutics 1991;259(1):30-7.
1991: Richard B Rothman; A Mele; A A Reid; H C Akunne; N Greig; A Thurkauf; B R de Costa; Kenner C Rice; A Pert
GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine.
Pharmacology, biochemistry, and behavior 1991;40(2):387-97.
1991: H C Akunne; A A Reid; A Thurkauf; Arthur E Jacobson; B R de Costa; Kenner C Rice; M P Heyes; Richard B Rothman
[3H]1-[2-(2-thienyl)cyclohexyl]piperidine labels two high-affinity binding sites in human cortex: further evidence for phencyclidine binding sites associated with the biogenic amine reuptake complex.
Synapse (New York, N.Y.) 1991;8(4):289-300.
1991: Carlo Ferrarese; Alessandro Guidotti; E Costa; R S Miletich; Kenner C Rice; B R de Costa; M J Fulham; G Di Chiro
In vivo study of NMDA-sensitive glutamate receptor by fluorothienylcyclohexylpiperidine [correction of fluorothienylcycloexylpiperidine], a possible ligand for positron emission tomography.
Neuropharmacology 1991;30(8):899-905.
1991: R Kawai; Richard E Carson; B Dunn; Amy Hauck Newman; Kenner C Rice; Ronald Blasberg
Regional brain measurement of Bmax and KD with the opiate antagonist cyclofoxy: equilibrium studies in the conscious rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1991;11(4):529-44.
1991: Richard B Rothman; V Bykov; A Mahboubi; J B Long; Q Jiang; F Porreca; B R de Costa; Arthur E Jacobson; Kenner C Rice; John Holaday
Interaction of beta-funaltrexamine with [3H]cycloFOXY binding in rat brain: further evidence that beta-FNA alkylates the opioid receptor complex.
Synapse (New York, N.Y.) 1991;8(2):86-99.
1991: P Horan; B R de Costa; Kenner C Rice; F Porreca
Differential antagonism of U69,593- and bremazocine-induced antinociception by (-)-UPHIT: evidence of kappa opioid receptor multiplicity in mice.
The Journal of pharmacology and experimental therapeutics 1991;257(3):1154-61.
1991: B R de Costa; A H Lewin; Kenner C Rice; Phil Skolnick; J A Schoenheimer
Novel site-directed affinity ligands for GABA-gated chloride channels: synthesis, characterization, and molecular modeling of 1-(isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclo[2.2.2]octanes .
Journal of medicinal chemistry 1991;34(5):1531-8.
1991: HAN XU; C H Kim; Y C Zhu; Richard J. Weber; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
(+)-cis-3-methylfentanyl and its analogs bind pseudoirreversibly to the mu opioid binding site: evidence for pseudoallosteric modulation.
Neuropharmacology 1991;30(5):455-62.
1991: P C Contreras; D M Ragan; M E Bremer; T H Lanthorn; N M Gray; S Iyengar; Arthur E Jacobson; Kenner C Rice; B R de Costa
Evaluation of U-50,488H analogs for neuroprotective activity in the gerbil.
Brain research 1991;546(1):79-82.
1991: S P Berger; R E Martenson; P Laing; A Thurkauf; B Decosta; Kenner C Rice; S M Paul
Photoaffinity labeling of the dopamine reuptake carrier protein with 3-azido[3H]GBR-12935.
Molecular pharmacology 1991;39(4):429-35.
1991: Richard B Rothman; A Mahboubi; V Bykov; C H Kim; Arthur E Jacobson; Kenner C Rice
Probing the opioid receptor complex with (+)-trans-superfit. I. Evidence that [D-Pen2,D-Pen5]enkephalin interacts with high affinity at the delta cx binding site.
Peptides 1991;12(2):359-64.
1991: Jeffrey M Witkin; Rolley E. Johnson; Jerome H Jaffe; Steven R Goldberg; N A Grayson; Kenner C Rice; Jonathan L Katz
The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine.
Drug and alcohol dependence 1991;27(2):177-84.
1991: EJ Moody; A H Lewin; B R de Costa; Kenner C Rice; Phil Skolnick
Site-specific acylation of GABA-gated Cl- channels: effects on 36Cl- uptake.
European journal of pharmacology 1991;206(2):113-8.
1991: Miles Herkenham; A B Lynn; M R Johnson; L S Melvin; B R de Costa; Kenner C Rice
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(2):563-83.
1991: Richard B Rothman; A Reid; A Mahboubi; C H Kim; B R De Costa; Arthur E Jacobson; Kenner C Rice
Labeling by [3H]1,3-di(2-tolyl)guanidine of two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel antagonists and pseudoallosteric modulation by sigma ligands.
Molecular pharmacology 1991;39(2):222-32.
1991: HAN XU; Q Ni; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
Preliminary ligand binding data for subtypes of the delta opioid receptor in rat brain membranes.
Life sciences 1991;49(18):PL141-6.
1991: Richard B Rothman; J B Long; V Bykov; H Xu; Arthur E Jacobson; Kenner C Rice; John Holaday
Upregulation of the opioid receptor complex by the chronic administration of morphine: a biochemical marker related to the development of tolerance and dependence.
Peptides 1991;12(1):151-60.
1991: Richard B Rothman; HAN XU; M Seggel; Arthur E Jacobson; Kenner C Rice; G A Brine; F I Carroll
RTI-4614-4: an analog of (+)-cis-3-methylfentanyl with a 27,000-fold binding selectivity for mu versus delta opioid binding sites.
Life sciences 1991;48(23):PL111-6.
1990: J Michael Walker; Wayne D Bowen; F O Walker; Rae Reiko Matsumoto; B De Costa; Kenner C Rice
Sigma receptors: biology and function.
Pharmacological reviews 1990;42(4):355-402.
1990: R Kawai; Y Sawada; M Channing; B Dunn; A H Newman; Kenner C Rice; Ronald Blasberg
Kinetic analysis of the opiate antagonist cyclofoxy in rat brain: simultaneous infusion of active and inactive enantiomers.
The Journal of pharmacology and experimental therapeutics 1990;255(2):826-35.
1990: B R de Costa; Kenner C Rice; Wayne D Bowen; A Thurkauf; Richard B Rothman; L Band; Arthur E Jacobson; L Radesca; P C Contreras; N M Gray
Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.
Journal of medicinal chemistry 1990;33(11):3100-10.
1990: A A Reid; C H Kim; A Thurkauf; J A Monn; B de Costa; Arthur E Jacobson; Kenner C Rice; Wayne D Bowen; Richard B Rothman
Wash-resistant inhibition of phencyclidine- and haloperidol-sensitive sigma receptor sites in guinea pig brain by putative affinity ligands: determination of selectivity.
Neuropharmacology 1990;29(11):1047-53.
1990: R Kawai; Y Sawada; M Channing; A H Newman; Kenner C Rice; Ronald Blasberg
BBB transport and rapid tissue binding of cyclofoxy: comparison of active and inactive enantiomers.
The American journal of physiology 1990;259(4 Pt 2):H1278-87.
1990: A A Reid; M V Mattson; B R de Costa; A Thurkauf; Arthur E Jacobson; J A Monn; Kenner C Rice; Richard B Rothman
Specificity of phencyclidine-like drugs and benzomorphan opiates for two high affinity phencyclidine binding sites in guinea pig brain.
Neuropharmacology 1990;29(9):811-7.
1990: Richard B Rothman; J B Long; V Bykov; Arthur E Jacobson; Kenner C Rice; John Holaday
Pretreatment of rats with the irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors.
Neuropharmacology 1990;29(9):805-10.
1990: A Thurkauf; B de Costa; M V Mattson; Charles France; M T Price; J W Olney; James H Woods; Arthur E Jacobson; Kenner C Rice
Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines.
Journal of medicinal chemistry 1990;33(8):2211-5.
1990: R T McCabe; B R de Costa; R L Miller; R H Havunjian; Kenner C Rice; Phil Skolnick
Characterization of benzodiazepine receptors with fluorescent ligands.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(11):2934-40.
1990: Kenner C Rice; G T Bolger
Interactions between phencyclidine and nifedipine at 45Ca2(+)-uptake sites on mouse brain neurons.
Biochemical pharmacology 1990;39(11):1825-7.
1990: A Thurkauf; B de Costa; S Yamaguchi; M V Mattson; Arthur E Jacobson; Kenner C Rice; Michael A Rogawski
Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues.
Journal of medicinal chemistry 1990;33(5):1452-8.
1990: Rae Reiko Matsumoto; M K Hemstreet; N L Lai; A Thurkauf; B R De Costa; Kenner C Rice; S B Hellewell; Wayne D Bowen; J Michael Walker
Drug specificity of pharmacological dystonia.
Pharmacology, biochemistry, and behavior 1990;36(1):151-5.
1990: C R Creveling; M E Bell; T R Burke; E Chang; G A Lewandowski-Lovenberg; C H Kim; Kenner C Rice; John W Daly
Procaine isothiocyanate: an irreversible inhibitor of the specific binding of [3H]batrachotoxinin-A benzoate to sodium channels.
Neurochemical research 1990;15(4):441-8.
1990: B R de Costa; Richard B Rothman; V Bykov; L Band; A Pert; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 17. Synthesis and evaluation of a series of trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacet amide (U50,488) related isothiocyanate derivatives as opioid receptor affinity ligands.
Journal of medicinal chemistry 1990;33(4):1171-6.
1990: Miles Herkenham; A B Lynn; M D Little; M R Johnson; L S Melvin; B R de Costa; Kenner C Rice
Cannabinoid receptor localization in brain.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1932-6.
1990: Richard B Rothman; V Bykov; B R de Costa; Arthur E Jacobson; Kenner C Rice; L S Brady
Interaction of endogenous opioid peptides and other drugs with four kappa opioid binding sites in guinea pig brain.
Peptides 1990;11(2):311-31.
1990: J A Monn; A Thurkauf; M V Mattson; Arthur E Jacobson; Kenner C Rice
Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site.
Journal of medicinal chemistry 1990;33(3):1069-76.
1990: T Nabeshima; S Yoshida; H Morinaka; T Kameyama; A Thurkauf; Kenner C Rice; Arthur E Jacobson; J A Monn; A K Cho
MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO.
Neuroscience letters 1990;108(3):321-7.
1990: L Band; HAN XU; V Bykov; N Greig; C H Kim; A Newman; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
The potent opioid agonist, (+)-cis-3-methylfentanyl binds pseudoirreversibly to the opioid receptor complex in vitro and in vivo: evidence for a novel mechanism of action.
Life sciences 1990;47(24):2231-40.
1990: A A Reid; J A Monn; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
Pseudoallosteric modulation by (+)-MK801 of NMDA-coupled phencyclidine binding sites.
Life sciences 1990;47(16):PL77-82.
1990: Richard B Rothman; V Bykov; B R de Costa; Arthur E Jacobson; Kenner C Rice; L S Brady
Evidence for four opioid kappa binding sites in guinea pig brain.
Progress in clinical and biological research 1990;328():9-12.
1990: J Michael Walker; S L Patrick; A Thurkauf; Kenner C Rice; Wayne D Bowen
Inhibition of cholinergic analgesia by (+)-opiates.
Progress in clinical and biological research 1990;328():81-4.
1990: L Band; B R de Costa; V Bykov; A Pert; Kenner C Rice; Richard B Rothman
The affinity ligand "UPHIT" acylates kappa opioid binding sites in vivo.
Progress in clinical and biological research 1990;328():77-80.
1990: Wayne D Bowen; B DeCosta; S B Hellewell; A Thurkauf; J Michael Walker; Kenner C Rice
Characterization of [3H] (+)-pentazocine, a highly selective sigma ligand.
Progress in clinical and biological research 1990;328():117-20.
1990: Wanda Williams; Kenner C Rice; Richard J. Weber
Nonpeptide opioids: in vivo effects on the immune system.
NIDA research monograph 1990;105():404-7.
1990: Kenner C Rice; J M Cook
In memoriam: Ulrich Weiss 1908-1989.
NIDA research monograph 1990;105():130-2.
1990: H Akunne; B R deCosta; Kenner C Rice; Arthur E Jacobson; Richard B Rothman
Evidence for high and low affinity [3H]cocaine binding sites associated with the serotonin reuptake complex in guinea pig brain: allosteric modulation by paroxetine.
NIDA research monograph 1990;105():547-8.
1990: Richard B Rothman; A Mele; A A Reid; H Akunne; N Grieg; A Thurkauf; B R deCosta; Kenner C Rice; A Pert
Preliminary evidence that the high affinity dopamine reuptake inhibitor, GBR12909, antagonizes the ability of cocaine to elevate extracellular levels of dopamine.
NIDA research monograph 1990;105():359-60.
1990: B R deCosta; R R Rothman; H Akunne; Arthur E Jacobson; Kenner C Rice
Synthesis and evaluation of novel BTCP based affinity ligands for the dopamine reuptake complex.
NIDA research monograph 1990;105():437-8.
1990: Richard J. Weber; L C Band; B deCosta; A Pert; Kenner C Rice
Neural control of immune function: opioids, opioid receptors and immunosuppression.
NIDA research monograph 1990;105():96-102.
1990: L A Radesca; B R deCosta; Wayne D Bowen; L J DiPaolo; Kenner C Rice
Identification of a novel class of highly potent sigma ligands related to the kappa-selective agonist U50,488.
NIDA research monograph 1990;105():518-9.
1990: HAN XU; C H Kim; Y C Zhu; Richard J. Weber; Kenner C Rice; Richard B Rothman
Pseudoirreversible binding of opiates to opioid receptor subtypes in rat brain: a quantitative study.
NIDA research monograph 1990;105():410-1.
1990: J T Linders; T R Burke; Arthur E Jacobson; Kenner C Rice
Oxide-bridged 5-phenylmorphans as probes for narcotic receptor mediated phenomena.
NIDA research monograph 1990;105():388-9.
1990: Q Jiang; Kenner C Rice; B deCosta; F Porreca
Effects of oxymorphindole on morphine induced-antinociception in mice and rats.
NIDA research monograph 1990;105():384-5.
1990: N A Grayson; Richard B Rothman; HAN XU; Kenner C Rice
Pharmacological properties of (+)-buprenorphine and (+)-diprenorphine.
NIDA research monograph 1990;105():380-1.
1990: Richard B Rothman; A Mahboubi; A A Reid; C H Kim; B R deCosta; Arthur E Jacobson; Kenner C Rice
[3H]1,3-Di(2-tolyl)guanidine labels two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel blockers and sigma ligands.
NIDA research monograph 1990;105():335-6.
1989: C Benkelfat; C S Aulakh; V Bykov; Kenner C Rice; B R De Costa; Richard B Rothman
Apparent down-regulation of rat brain mu- and kappa-opioid binding sites labelled with [3H]cycloFOXY following chronic administration of the potent 5-hydroxytryptamine reuptake blocker, clomipramine.
The Journal of pharmacy and pharmacology 1989;41(12):865-7.
1989: Richard B Rothman; J B Long; John Holaday; V Bykov; B R de Costa; C H Kim; Arthur E Jacobson; Kenner C Rice
A study of the interaction of the alkylating agent, NIH10236, with opioid receptors in vitro and in vivo.
Neuropharmacology 1989;28(12):1349-56.
1989: Richard B Rothman; A A Reid; J A Monn; Arthur E Jacobson; Kenner C Rice
The psychotomimetic drug phencyclidine labels two high affinity binding sites in guinea pig brain: evidence for N-methyl-D-aspartate-coupled and dopamine reuptake carrier-associated phencyclidine binding sites.
Molecular pharmacology 1989;36(6):887-96.
1989: Richard B Rothman; A Mele; A A Reid; H Akunne; N Greig; A Thurkauf; Kenner C Rice; A Pert
Tight binding dopamine reuptake inhibitors as cocaine antagonists. A strategy for drug development.
FEBS letters 1989;257(2):341-4.
1989: Richard B Rothman; Charles France; V Bykov; B R De Costa; Arthur E Jacobson; James H Woods; Kenner C Rice
Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes.
European journal of pharmacology 1989;167(3):345-53.
1989: B R de Costa; Wayne D Bowen; S B Hellewell; C George; Richard B Rothman; A A Reid; J Michael Walker; Arthur E Jacobson; Kenner C Rice
Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.
Journal of medicinal chemistry 1989;32(8):1996-2002.
1989: T Nabeshima; K Tohyama; A Noda; Y Maeda; M Hiramatsu; S M Harrer; T Kameyama; H Furukawa; Arthur E Jacobson; Kenner C Rice
Effects of metaphit on phencyclidine and serotonin2 receptors.
Neuroscience letters 1989;102(2-3):303-8.
1989: B R de Costa; Wayne D Bowen; S B Hellewell; J Michael Walker; A Thurkauf; Arthur E Jacobson; Kenner C Rice
Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors.
FEBS letters 1989;251(1-2):53-8.
1989: B R de Costa; L Band; Richard B Rothman; Arthur E Jacobson; V Bykov; A Pert; Kenner C Rice
Synthesis of an affinity ligand ('UPHIT') for in vivo acylation of the kappa-opioid receptor.
FEBS letters 1989;249(2):178-82.
1989: Michael A Rogawski; A Thurkauf; S Yamaguchi; Kenner C Rice; A E Jacobson; M V Mattson
Anticonvulsant activities of 1-phenylcyclohexylamine and its conformationally restricted analog 1,1-pentamethylenetetrahydroisoquinoline.
The Journal of pharmacology and experimental therapeutics 1989;249(3):708-12.
1989: C H Kim; Richard B Rothman; Arthur E Jacobson; M V Mattson; V Bykov; R A Streaty; W A Klee; C George; J B Long; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.
Journal of medicinal chemistry 1989;32(6):1392-8.
1989: L S Bluth; Kenner C Rice; A E Jacobson; Wayne D Bowen
Acylation of sigma receptors by Metaphit, an isothiocyanate derivative of phencyclidine.
European journal of pharmacology 1989;161(2-3):273-7.
1989: R T McCabe; J A Schoenheimer; Phil Skolnick; Amy Hauck Newman; Kenner C Rice; J A Reig; David Klein
[3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland.
FEBS letters 1989;244(2):263-7.
1989: A H Lewin; B R de Costa; Kenner C Rice; Phil Skolnick
meta- and para-isothiocyanato-t-butylbicycloorthobenzoate: irreversible ligands of the gamma-aminobutyric acid-regulated chloride ionophore.
Molecular pharmacology 1989;35(2):189-94.
1989: G T Bolger; Amy Hauck Newman; Kenner C Rice; H W Lueddens; Anthony Basile; Phil Skolnick
Characterization of the effects of AHN 086, an irreversible ligand of "peripheral" benzodiazepine receptors, on contraction in guinea-pig atrial and ileal longitudinal smooth muscle.
Canadian journal of physiology and pharmacology 1989;67(2):126-34.
1989: Richard B Rothman; V Bykov; J B Long; L S Brady; Arthur E Jacobson; Kenner C Rice; John Holaday
Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites.
European journal of pharmacology 1989;160(1):71-82.
1989: EJ Moody; M Mattson; Amy Hauck Newman; Kenner C Rice; Phil Skolnick
Stereospecific reversal of nitrous oxide analgesia by naloxone.
Life sciences 1989;44(11):703-9.
1989: Phil Skolnick; J C Marvizón; B W Jackson; J A Monn; Kenner C Rice; A H Lewin
Blockade of N-methyl-D-aspartate induced convulsions by 1-aminocyclopropanecarboxylates.
Life sciences 1989;45(18):1647-55.
1989: S Richardson; Miles Herkenham; S Mirsadeghi; M R Johnson; L S Melvin; Kenner C Rice
Progress toward the synthesis of potential affinity ligands for the analgesic cannabinoid receptor based on CP-55,244.
NIDA research monograph 1989;95():532-3.
1989: L Band; V Bykov; N Greig; C H Kim; A Hauck-Newman; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
In vivo binding of (+)-cis methylfentanyl at the opiate receptor complex and behavioral correlates: evidence for a novel mechanism of action.
NIDA research monograph 1989;95():554-5.
1989: A A Reid; J A Monn; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
Characterization of NMDA-coupled and dopamine reuptake carrier coupled [3H]-TCP binding sites in guinea pig brain.
NIDA research monograph 1989;95():530-1.
1989: A Thurkauf; J Monn; M V Mattson; Arthur E Jacobson; Kenner C Rice
Structural and conformational aspects of the binding of aryl-alkyl amines to the phencyclidine binding site.
NIDA research monograph 1989;95():51-6.
1989: Amy Hauck Newman; R T McCabe; J A Schoenheimer; Phil Skolnick; Kenner C Rice; J A Reig; David Klein
[3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland.
NIDA research monograph 1989;95():285-6.
1988: Richard B Rothman; V Bykov; A Reid; B R De Costa; A H Newman; Arthur E Jacobson; Kenner C Rice
A brief study of the selectivity of norbinaltorphimine, (-)-cyclofoxy, and (+)-cyclofoxy among opioid receptor subtypes in vitro.
Neuropeptides 1988;12(3):181-7.
1988: G T Bolger; Phil Skolnick; Kenner C Rice; B A Weissman
Differential regulation of mu-opiate receptors in heroin- and morphine-dependent rats.
FEBS letters 1988;234(1):22-6.
1988: Richard B Rothman; V Bykov; A H Newman; Arthur E Jacobson; Kenner C Rice
Interaction of enantiomeric pairs of opiates with phencyclidine binding sites in rat brain: identification of (+) pentazocine as a ligand potentially suitable for imaging sigma binding sites using positron emission tomography.
Neuropeptides 1988;12(1):1-5.
1988: Wayne D Bowen; B N Kirschner; A H Newman; Kenner C Rice
Sigma receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain.
European journal of pharmacology 1988;149(3):399-400.
1988: Wayne D Bowen; P A Rodrigues; T E Wanzor; A E Jacobson; Kenner C Rice
Differential coupling of mu-competitive and mu-noncompetitive delta opiate receptors to guanine nucleotide binding proteins in rat brain membranes.
Biochemical pharmacology 1988;37(3):467-72.
1988: Richard B Rothman; V Bykov; D Ofri; Kenner C Rice
LY164929: a highly selective ligand for the lower affinity [3H]D-Ala2-D-Leu-5-enkephalin binding site.
Neuropeptides 1988;11(1):13-6.
1988: Richard B Rothman; V Bykov; Kenner C Rice; Arthur E Jacobson; G N Kooper; W D Bowen
Tritiated-6-beta-fluoro-6-desoxy-oxymorphone ([3H]FOXY): a new ligand and photoaffinity probe for the mu opioid receptors.
Neuropeptides 1988;11(1):1-6.
1987: Arthur E Jacobson; E A Harrison; M V Mattson; M F Rafferty; Kenner C Rice; James H Woods; Gail Winger; R E Solomon; R A Lessor; J V Silverton
Enantiomeric and diastereomeric dioxadrols: behavioral, biochemical and chemical determination of the configuration necessary for phencyclidine-like properties.
The Journal of pharmacology and experimental therapeutics 1987;243(1):110-7.
1987: Amy Hauck Newman; H W Lueddens; Phil Skolnick; Kenner C Rice
Novel irreversible ligands specific for "peripheral" type benzodiazepine receptors: (+/-)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N- (2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl )-2H-1,4-benzodiazepin-2-one.
Journal of medicinal chemistry 1987;30(10):1901-5.
1987: H Awaya; Everette L May; Mario D Aceto; L S Harris; J V Silverton; Kenner C Rice; M V Mattson; Arthur E Jacobson
Hexahydro-1H-1-pyrindines from acid rearrangement of 9-alkylidene-5-(m-methoxyphenyl)-2-methylmorphans. A new structural type of narcotic antagonists.
Journal of medicinal chemistry 1987;30(5):947-50.
1987: Amy Hauck Newman; H W Lueddens; Phil Skolnick; Kenner C Rice
Synthesis and biochemical characterization of two novel irreversible ligands specific for "peripheral" benzodiazepine receptors.
NIDA research monograph 1987;76():356-62.
1986: P C Contreras; Steven W Johnson; R Freedman; Barry Hoffer; K Olsen; M F Rafferty; R A Lessor; Kenner C Rice; Arthur E Jacobson; T L O'Donohue
Metaphit, an acylating ligand for phencyclidine receptors: characterization of in vivo actions in the rat.
The Journal of pharmacology and experimental therapeutics 1986;238(3):1101-7.
1986: H W Lueddens; Amy Hauck Newman; Kenner C Rice; Phil Skolnick
AHN 086: an irreversible ligand of "peripheral" benzodiazepine receptors.
Molecular pharmacology 1986;29(6):540-5.
1986: Y Wang; K Pang; Arthur E Jacobson; R Lessor; Kenner C Rice; Barry Hoffer
Interactions of phencyclidine with hippocampal circuitry: evidence for neuronal heterogeneity.
Pharmacology, biochemistry, and behavior 1986;24(5):1403-7.
1986: Wouter Koek; James H Woods; Arthur E Jacobson; Kenner C Rice; R A Lessor
Metaphit, a proposed phencyclidine receptor acylator: phencyclidine-like behavioral effects and evidence of absence of antagonist activity in pigeons and in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 1986;237(2):386-92.
1986: Y Wang; M Palmer; R Freedman; Barry Hoffer; M V Mattson; R A Lessor; Kenner C Rice; Arthur E Jacobson
Antagonism of phencyclidine action by metaphit in rat cerebellar Purkinje neurons: an electrophysiological study.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2724-7.
1986: R A Lessor; M V Mattson; Kenner C Rice; Arthur E Jacobson
Electrophilic affinity ligands for the phencyclidine (PCP) receptor.
NIDA research monograph 1986;67():138-44.
1985: Wouter Koek; R Head; Elzbieta Holsztynska; James H Woods; Edward Domino; Arthur E Jacobson; M F Rafferty; Kenner C Rice; R A Lessor
Effects of metaphit, a proposed phencyclidine receptor acylator, on catalepsy in pigeons.
The Journal of pharmacology and experimental therapeutics 1985;234(3):648-53.
1985: P C Contreras; M F Rafferty; R A Lessor; Kenner C Rice; Arthur E Jacobson; T L O'Donohue
A specific alkylating ligand for phencyclidine (PCP) receptors antagonizes PCP behavioral effects.
European journal of pharmacology 1985;111(3):405-6.
1984: E A Harrison; M F Rafferty; Kenner C Rice; C R Creveling; Gail Winger; James H Woods; Arthur E Jacobson
Evidence for separation of anesthetic activity from prototypic phencyclidine action in drug discrimination by molecular modification of dioxadrol, a phencyclidine-like dissociative anesthetic.
NIDA research monograph 1984;55():90-6.