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Bruce Bianchi

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Ping Han; Alla V Korepanova; Marc R Lake; Robert B Moreland; Ana Pereda-Lopez; Melissa H Vos; Bruce R Bianchi; Connie R Faltynek; Mark L Chiu
Development of ELISA to measure TRPV1 protein in rat tissues.
Jun Chen; Shailen K Joshi; Stanley Didomenico; Richard J Perner; Joe Mikusa; Donna M Gauvin; Jason A Segreti; Ping Han; Xu-Feng Zhang; Wende Niforatos; Bruce R Bianchi; Scott J Baker; Chengmin Zhong; Gricelda H Simler; Heath A McDonald; Robert G Schmidt; Steve McGaraughty; Katharine L Chu; Connie R Faltynek; Michael E Kort; Regina M Reilly; Philip R Kym
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.
Robert G Schmidt; Erol K Bayburt; Steven P Latshaw; John R Koenig; Jerome F Daanen; Heath A McDonald; Bruce R Bianchi; Chengmin Zhong; Shailen Joshi; Prisca Honore; Kennan Marsh; Chih-Hung Lee; Connie R Faltynek; Arthur Gomtsyan
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.

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All Publications

2011: Ping Han; Alla V Korepanova; Marc R Lake; Robert B Moreland; Ana Pereda-Lopez; Melissa H Vos; Bruce R Bianchi; Connie R Faltynek; Mark L Chiu
Development of ELISA to measure TRPV1 protein in rat tissues.
Journal of neuroscience methods 2011;200(2):144-52.
2011: Jun Chen; Shailen K Joshi; Stanley Didomenico; Richard J Perner; Joe Mikusa; Donna M Gauvin; Jason A Segreti; Ping Han; Xu-Feng Zhang; Wende Niforatos; Bruce R Bianchi; Scott J Baker; Chengmin Zhong; Gricelda H Simler; Heath A McDonald; Robert G Schmidt; Steve McGaraughty; Katharine L Chu; Connie R Faltynek; Michael E Kort; Regina M Reilly; Philip R Kym
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.
Pain 2011;152(5):1165-72.
2011: Robert G Schmidt; Erol K Bayburt; Steven P Latshaw; John R Koenig; Jerome F Daanen; Heath A McDonald; Bruce R Bianchi; Chengmin Zhong; Shailen Joshi; Prisca Honore; Kennan Marsh; Chih-Hung Lee; Connie R Faltynek; Arthur Gomtsyan
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2011;21(5):1338-41.
2010: Pamela S Puttfarcken; Ping Han; Shailen K Joshi; Torben R Neelands; Donna M Gauvin; Scott J Baker; La Geisha R Lewis; Bruce R Bianchi; Joe Mikusa; John R Koenig; Richard J Perner; Michael E Kort; Prisca Honore; Connie R Faltynek; Philip R Kym; Regina M Reilly
A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model.
Pain 2010;150(2):319-26.
2010: Brian S Brown; Ryan G Keddy; Richard J Perner; Stanley Didomenico; John R Koenig; Tammie K Jinkerson; Steven M Hannick; Heath A McDonald; Bruce R Bianchi; Prisca Honore; Pamela S Puttfarcken; Robert B Moreland; Kennan Marsh; Connie R Faltynek; Abel Lee
Discovery of TRPV1 antagonist ABT-116.
Bioorganic & medicinal chemistry letters 2010;20(11):3291-4.
2010: Bruce R Bianchi; Rachid El Kouhen; Jun Chen; Pamela S Puttfarcken
Binding of [(3)H]A-778317 to native transient receptor potential vanilloid-1 (TRPV1) channels in rat dorsal root ganglia and spinal cord.
European journal of pharmacology 2010;633(1-3):15-23.
2010: Jun Chen; Sujatha Gopalakrishnan; Marc R Lake; Bruce R Bianchi; John Locklear; Regina M Reilly
Application of large-scale transient transfection to cell-based functional assays for ion channels and GPCRs.
Methods in enzymology 2010;485():293-309.
2009: Alla Korepanova; Ana Pereda-Lopez; Larry R Solomon; Karl A Walter; Marc R Lake; Bruce R Bianchi; Heath A McDonald; Torben R Neelands; Jianwei Shen; Edmund D Matayoshi; Robert B Moreland; Mark L Chiu
Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies.
Protein expression and purification 2009;65(1):38-50.
2009: Jun Chen; Donghee Kim; Bruce R Bianchi; Eric J Cavanaugh; Connie R Faltynek; Philip R Kym; Regina M Reilly
Pore dilation occurs in TRPA1 but not in TRPM8 channels.
Molecular pain 2009;5():3.
2008: Brian S Brown; Ryan G Keddy; Guo Zhu Zheng; Robert G Schmidt; John R Koenig; Heath A McDonald; Bruce R Bianchi; Prisca Honore; Michael F Jarvis; Carol S Surowy; James S Polakowski; Kennan Marsh; Connie R Faltynek; Abel Lee
Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Bioorganic & medicinal chemistry 2008;16(18):8516-25.
2008: Carol S Surowy; Torben R Neelands; Bruce R Bianchi; Steve McGaraughty; Rachid El Kouhen; Ping Han; Katharine L Chu; Heath A McDonald; Melissa Vos; Wende Niforatos; Erol K Bayburt; Arthur Gomtsyan; Abel Lee; Prisca Honore; James P Sullivan; Michael F Jarvis; Connie R Faltynek
(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo.
The Journal of pharmacology and experimental therapeutics 2008;326(3):879-88.
2007: Bruce R Bianchi; Rachid El Kouhen; Torben R Neelands; Abel Lee; Arthur Gomtsyan; Shirish N Raja; Sriajan N Vaidyanathan; Bruce W Surber; Heath A McDonald; Carol S Surowy; Connie R Faltynek; Robert B Moreland; Michael F Jarvis; Pamela S Puttfarcken
[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.
The Journal of pharmacology and experimental therapeutics 2007;323(1):285-93.
2007: Bruce R Bianchi; Robert B Moreland; Connie R Faltynek; Jun Chen
Application of large-scale transiently transfected cells to functional assays of ion channels: different targets and assay formats.
Assay and drug development technologies 2007;5(3):417-24.
2007: Ping Han; Heath A McDonald; Bruce R Bianchi; Rachid El Kouhen; Melissa H Vos; Michael F Jarvis; Connie R Faltynek; Robert B Moreland
Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes.
Biochemical pharmacology 2007;73(10):1635-45.
2006: M Cui; Prisca Honore; Chengmin Zhong; Donna M Gauvin; Joe Mikusa; Gricelda Hernandez; Prasant Chandran; Arthur Gomtsyan; B Brown; Erol K Bayburt; Kennan Marsh; Bruce R Bianchi; Heath McDonald; Wende Niforatos; Torben R Neelands; Robert B Moreland; Michael W Decker; Chih Hung Lee; James P Sullivan; Connie R Faltynek
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(37):9385-93.
2006: Bruce R Bianchi; Abel Lee; Michael F Jarvis; Rachid El Kouhen; Robert B Moreland; Connie R Faltynek; Pamela S Puttfarcken
Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system.
European journal of pharmacology 2006;537(1-3):20-30.
2005: Steve McGaraughty; Prisca Honore; Carol T Wismer; Joe Mikusa; Chang Z Zhu; Heath A McDonald; Bruce R Bianchi; Connie R Faltynek; Michael F Jarvis
Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain.
British journal of pharmacology 2005;146(2):180-8.
2005: Rachid El Kouhen; Carol S Surowy; Bruce R Bianchi; Torben R Neelands; Heath A McDonald; Wende Niforatos; Arthur Gomtsyan; Abel Lee; Prisca Honore; James P Sullivan; Michael F Jarvis; Connie R Faltynek
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid.
The Journal of pharmacology and experimental therapeutics 2005;314(1):400-9.
2004: Michael F Jarvis; Bruce R Bianchi; John T Uchic; Jayne Cartmell; Abel Lee; Michael Williams; Connie R Faltynek
[3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors.
The Journal of pharmacology and experimental therapeutics 2004;310(1):407-16.
2002: Michael F Jarvis; Edward C Burgard; Steve McGaraughty; Prisca Honore; Kevin Lynch; Timothy Brennan; Alberto Subieta; Tim Van Biesen; Jayne Cartmell; Bruce R Bianchi; Wende Niforatos; Karen Kage; Haixia Yu; Joe Mikusa; Carol T Wismer; Chang Z Zhu; Katharine Chu; Abel Lee; Andrew O Stewart; James S Polakowski; Bryan Cox; Elizabeth A Kowaluk; Michael Williams; James Sullivan; Connie R Faltynek
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):17179-84.
2002: Prisca Honore; Joe Mikusa; Bruce R Bianchi; Heath McDonald; Jayne Cartmell; Connie R Faltynek; Michael F Jarvis
TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics.
Pain 2002;96(1-2):99-105.
2002: Heath A McDonald; Katharine L Chu; Bruce R Bianchi; David G McKenna; Clark A Briggs; Edward C Burgard; Kevin J Lynch; Connie R Faltynek; Jayne Cartmell; Michael F Jarvis
Potent desensitization of human P2X3 receptors by diadenosine polyphosphates.
European journal of pharmacology 2002;435(2-3):135-42.
1999: K Alexander; Wende Niforatos; Bruce R Bianchi; Edward C Burgard; Kevin J Lynch; Elizabeth A Kowaluk; Michael F Jarvis; Tim Van Biesen
Allosteric modulation and accelerated resensitization of human P2X(3) receptors by cibacron blue.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1135-42.
1999: Bruce R Bianchi; Kevin J Lynch; E Touma; Wende Niforatos; Edward C Burgard; Easaw Alexander; H S Park; Haixia Yu; R Metzger; Elizabeth A Kowaluk; Michael F Jarvis; Tim Van Biesen
Pharmacological characterization of recombinant human and rat P2X receptor subtypes.
European journal of pharmacology 1999;376(1-2):127-38.