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William Rice

Research Profile

Living Beings

HIV-1

Chemicals & Drugs

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Virus Replication

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Amino Acid Sequences

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Anand Mayasundari; William G Rice; Jonathan B Diminnie; David C Baker
Synthesis, resolution, and determination of the absolute configuration of the enantiomers of cis-4,5-dihydroxy-1,2-dithiane 1,1-dioxide, an HIV-1NCp7 inhibitor.
Marco L Schito; Atul Goel; Yongsheng Song; John K Inman; Rasem J Fattah; William G Rice; Jim A Turpin; Alan Sher; Ettore Appella
In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model.
Yongsheng Song; Atul Goel; venkatesha basrur; Paula E A Roberts; Judy A Mikovits; John K Inman; Jim A Turpin; William G Rice; Ettore Appella
Synthesis and biological properties of amino acid amide ligand-based pyridinioalkanoyl thioesters as anti-HIV agents.

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All Publications

2003: Anand Mayasundari; William G Rice; Jonathan B Diminnie; David C Baker
Synthesis, resolution, and determination of the absolute configuration of the enantiomers of cis-4,5-dihydroxy-1,2-dithiane 1,1-dioxide, an HIV-1NCp7 inhibitor.
Bioorganic & medicinal chemistry 2003;11(14):3215-9.
2003: Marco L Schito; Atul Goel; Yongsheng Song; John K Inman; Rasem J Fattah; William G Rice; Jim A Turpin; Alan Sher; Ettore Appella
In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model.
AIDS research and human retroviruses 2003;19(2):91-101.
2002: Yongsheng Song; Atul Goel; venkatesha basrur; Paula E A Roberts; Judy A Mikovits; John K Inman; Jim A Turpin; William G Rice; Ettore Appella
Synthesis and biological properties of amino acid amide ligand-based pyridinioalkanoyl thioesters as anti-HIV agents.
Bioorganic & medicinal chemistry 2002;10(5):1263-73.
2002: Atul Goel; Sharlyn J Mazur; Rasem J Fattah; Tracy L Hartman; Jim A Turpin; Mingjun Huang; William G Rice; Ettore Appella; John K Inman
Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(5):767-70.
2000: venkatesha basrur; Y Song; Sharlyn J Mazur; Yuichiro Higashimoto; Jim A Turpin; William G Rice; John K Inman; Ettore Appella
Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action.
The Journal of biological chemistry 2000;275(20):14890-7.
1999: Nouri Neamati; Jim A Turpin; Heather E Winslow; JL Christensen; K Williamson; Ann H Orr; William G Rice; Yves Pommier; Antonio Garofalo; Antonella Brizzi; Giuseppe Campiani; Isabella Fiorini; Vito Nacci
Thiazolothiazepine inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1999;42(17):3334-41.
1999: Mark Cushman; S Insaf; G Paul; JA Ruell; E De Clercq; D Schols; C Pannecouque; M Witvrouw; CA Schaeffer; Jim A Turpin; K Williamson; William G Rice
Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.
Journal of medicinal chemistry 1999;42(10):1767-77.
1999: Z Lin; Nouri Neamati; Hong Zhao; Y Kiryu; Jim A Turpin; Claudia Aberham; Klaus Strebel; Kurt W Kohn; M Witvrouw; C Pannecouque; zeger debyser; E De Clercq; William G Rice; Yves Pommier; Terrence R Burke
Chicoric acid analogues as HIV-1 integrase inhibitors.
Journal of medicinal chemistry 1999;42(8):1401-14.
1999: Jim A Turpin; Y Song; John K Inman; M Huang; Anders Wallqvist; A Maynard; David G Covell; William G Rice; Ettore Appella
Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers.
Journal of medicinal chemistry 1999;42(1):67-86.
1998: O M Zack Howard; J J Oppenheim; Melinda G Hollingshead; Joseph M Covey; James C Bigelow; J J McCormack; Robert W Buckheit; DJ Clanton; Jim A Turpin; William G Rice
Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application.
Journal of medicinal chemistry 1998;41(13):2184-93.
1998: Mark Cushman; A Casimiro-Garcia; E Hejchman; JA Ruell; M Huang; CA Schaeffer; K Williamson; William G Rice; Robert W Buckheit
New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 1998;41(12):2076-89.
1998: M Huang; A Maynard; Jim A Turpin; L Graham; G M Janini; David G Covell; William G Rice
Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins.
Journal of medicinal chemistry 1998;41(9):1371-81.
1998: Mark Cushman; S Insaf; JA Ruell; CA Schaeffer; William G Rice
Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent.
Bioorganic & medicinal chemistry letters 1998;8(7):833-6.
1998: Jim A Turpin; Robert W Buckheit; D Derse; Melinda G Hollingshead; K Williamson; C Palamone; MC Osterling; S A Hill; L Graham; CA Schaeffer; M Bu; M Huang; Wieslaw Cholody; Christopher J Michejda; William G Rice
Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription.
Antimicrobial agents and chemotherapy 1998;42(3):487-94.
1998: Mark Cushman; A Casimiro-Garcia; K Williamson; William G Rice
Synthesis of a non-nucleoside reverse transcriptase inhibitor in the alkenyldiarylmethane (ADAM) series with optimized potency and therapeutic index.
Bioorganic & medicinal chemistry letters 1998;8(2):195-8.
1997: John M Domagala; JP Bader; RD Gogliotti; Joseph P Sanchez; Michael A Stier; Y Song; J V N Vara Prasad; PJ Tummino; JD Scholten; P Harvey; T Holler; Stephen J Gracheck; DJ Hupe; William G Rice; R Schultz
A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: the 2,2'-dithiobisbenzamides.
Bioorganic & medicinal chemistry 1997;5(3):569-79.
1997: William G Rice; Jim A Turpin; M Huang; DJ Clanton; Robert W Buckheit; David G Covell; Anders Wallqvist; N B McDonnell; R N DeGuzman; Michael F Summers; L Zalkow; JP Bader; R D Haugwitz; Edward A Sausville
Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein.
Nature medicine 1997;3(3):341-5.
1997: William G Rice; David C Baker; CA Schaeffer; L Graham; M Bu; S Terpening; DJ Clanton; R Schultz; JP Bader; Robert W Buckheit; L Field; P K Singh; Jim A Turpin
Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins.
Antimicrobial agents and chemotherapy 1997;41(2):419-26.
1996: S M Halliday; C Lackman-Smith; JP Bader; William G Rice; D J Clanton; Leon H Zalkow; Robert W Buckheit
Inhibition of human immunodeficiency virus replication by the sulfonated stilbene dye resobene.
Antiviral research 1996;33(1):41-53.
1996: William G Rice; Jim A Turpin; CA Schaeffer; L Graham; D Clanton; Robert W Buckheit; Daniel W Zaharevitz; Michael F Summers; Anders Wallqvist; David G Covell
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
Journal of medicinal chemistry 1996;39(19):3606-16.
1996: Jim A Turpin; S J Terpening; CA Schaeffer; G Yu; C J Glover; R L Felsted; Edward A Sausville; William G Rice
Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles.
Journal of virology 1996;70(9):6180-9.
1996: Mark Cushman; W M Golebiewski; L Graham; Jim A Turpin; William G Rice; V Fliakas-Boltz; Robert W Buckheit
Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 1996;39(16):3217-27.
1996: A Mazumder; Shulin Wang; Nouri Neamati; Marc C Nicklaus; S Sunder; J Chen; GW Milne; William G Rice; Terrence R Burke; Yves Pommier
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
Journal of medicinal chemistry 1996;39(13):2472-81.
1996: Shulin Wang; GW Milne; X Yan; I J Posey; Marc C Nicklaus; L Graham; William G Rice
Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching.
Journal of medicinal chemistry 1996;39(10):2047-54.
1996: Rick Gussio; Nagarajan Pattabiraman; Daniel W Zaharevitz; G E Kellogg; Igor A Topol; William G Rice; CA Schaeffer; John W Erickson; Stanley K Burt
All-atom models for the non-nucleoside binding site of HIV-1 reverse transcriptase complexed with inhibitors: a 3D QSAR approach.
Journal of medicinal chemistry 1996;39(8):1645-50.
1996: Jim A Turpin; CA Schaeffer; M Bu; L Graham; Robert W Buckheit; D Clanton; William G Rice
Human immunodeficiency virus type-1 (HIV-1) replication is unaffected by human secretory leukocyte protease inhibitor.
Antiviral research 1996;29(2-3):269-77.
1995: William G Rice; J G Supko; L Malspeis; Robert W Buckheit; D Clanton; M Bu; L Graham; CA Schaeffer; Jim A Turpin; J Domagala; RD Gogliotti; JP Bader; S M Halliday; Lori V Coren; Raymond C Sowder; Larry O Arthur; Louis E. Henderson
Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.
Science (New York, N.Y.) 1995;270(5239):1194-7.
1995: D J Clanton; Robert W Buckheit; S J Terpening; R Kiser; Nicola Mongelli; A L Borgia; R Schultz; V Narayanan; JP Bader; William G Rice
Novel sulfonated and phosphonated analogs of distamycin which inhibit the replication of HIV.
Antiviral research 1995;27(4):335-54.
1995: XIAOFANG YU; Y Hathout; Catherine Fenselau; Raymond C Sowder; Louis E. Henderson; William G Rice; Jerome Mendeleyev; Ernest Kun
Specific disulfide formation in the oxidation of HIV-1 zinc finger protein nucleocapsid p7.
Chemical research in toxicology 1995;8(4):586-90.
1995: Mark Cushman; W M Golebiewski; Y Pommier; A Mazumder; D Reymen; E De Clercq; L Graham; William G Rice
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.
Journal of medicinal chemistry 1995;38(3):443-52.
1995: William G Rice; JP Bader
Discovery and in vitro development of AIDS antiviral drugs as biopharmaceuticals.
Advances in pharmacology (San Diego, Calif.) 1995;33():389-438.
1994: Mark Cushman; W M Golebiewski; James B McMahon; Robert W Buckheit; D J Clanton; O Weislow; R D Haugwitz; J P Bader; L Graham; William G Rice
Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction.
Journal of medicinal chemistry 1994;37(19):3040-50.
1994: EM Wondrak; Kazuyasu Sakaguchi; William G Rice; Ernest Kun; Alan R Kimmel; John M Louis
Removal of zinc is required for processing of the mature nucleocapsid protein of human immunodeficiency virus, type 1, by the viral protease.
The Journal of biological chemistry 1994;269(35):21948-50.
1993: William G Rice; CA Schaeffer; L Graham; M Bu; J S McDougal; S L Orloff; Francios VILLINGER; M Young; S Oroszlan; M R Fesen
The site of antiviral action of 3-nitrosobenzamide on the infectivity process of human immunodeficiency virus in human lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9721-4.
1993: A J Chuang; K F Killam; Ronald Y Chuang; William G Rice; CA Schaeffer; Jerome Mendeleyev; Ernest Kun
Inhibition of the replication of native and 3'-azido-2',3'-dideoxythymidine (AZT)-resistant simian immunodeficiency virus (SIV) by 3-nitrosobenzamide.
FEBS letters 1993;326(1-3):140-4.
1993: C S Gilbert; Rick Parmley; William G Rice; J M Kinkade
Heterogeneity of peroxidase-positive granules in normal human an Chédiak-Higashi neutrophils.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1993;41(6):837-49.
1993: William G Rice; CA Schaeffer; Brad Harten; Francios VILLINGER; T L South; Michael F Summers; Louis E. Henderson; Julian W Bess; Larry O Arthur; J S McDougal
Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds.
Nature 1993;361(6411):473-5.
1992: William G Rice; Christopher D Hillyer; Brad Harten; CA Schaeffer; M Dorminy; D A Lackey; E Kirsten; Jerome Mendeleyev; Kalman G Buki; A Hakam
Induction of endonuclease-mediated apoptosis in tumor cells by C-nitroso-substituted ligands of poly(ADP-ribose) polymerase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7703-7.
1988: P A Charp; William G Rice; R L Raynor; E Reimund; J M Kinkade; T Ganz; Michael Selsted; R I Lehrer; J F Kuo
Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils.
Biochemical pharmacology 1988;37(5):951-6.
1987: E Wilson; William G Rice; J M Kinkade; Alfred H Merrill; Roland R Arnold; David J. Lambeth
Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils.
Archives of biochemistry and biophysics 1987;259(1):204-14.
1987: Rick Parmley; William G Rice; J M Kinkade; C Gilbert; J C Barton
Peroxidase-containing microgranules in human neutrophils: physical, morphological, cytochemical, and secretory properties.
Blood 1987;70(5):1630-8.
1987: William G Rice; T Ganz; J M Kinkade; Michael Selsted; R I Lehrer; Rick Parmley
Defensin-rich dense granules of human neutrophils.
Blood 1987;70(3):757-65.
1986: William G Rice; J M Kinkade; Rick Parmley
High resolution of heterogeneity among human neutrophil granules: physical, biochemical, and ultrastructural properties of isolated fractions.
Blood 1986;68(2):541-55.