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Nigel Richards

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Whitney F Kellett; Ursula Rothlisberger; Steven C Almo; Elizabeth Brunk; Bijoy J Desai; Alexander A Fedorov; John A Gerlt; Nigel G J Richards
Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase.
Benjamin K Canales; Nigel G J Richards; Ammon B Peck
Rapid oxalate determination in blood and synthetic urine using a newly developed oxometer.
Hideyuki Ikeuchi; Takuya Otokawa; Yong-Mo Ahn; Lamees Hegazy; Jun Hiratake; Bunta Watanabe; Nigel G J Richards
A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells.

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2013: Whitney F Kellett; Ursula Rothlisberger; Steven C Almo; Elizabeth Brunk; Bijoy J Desai; Alexander A Fedorov; John A Gerlt; Nigel G J Richards
Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase.
Biochemistry 2013;52(11):1842-4.
2013: Benjamin K Canales; Nigel G J Richards; Ammon B Peck
Rapid oxalate determination in blood and synthetic urine using a newly developed oxometer.
Journal of endourology / Endourological Society 2013;27(2):145-8.
2012: Hideyuki Ikeuchi; Takuya Otokawa; Yong-Mo Ahn; Lamees Hegazy; Jun Hiratake; Bunta Watanabe; Nigel G J Richards
A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells.
Bioorganic & medicinal chemistry 2012;20(19):5915-27.
2012: Benjamin T Saylor; Mithila S Shukla; Karen N Allen; Alexander Angerhofer; W Wallace Cleland; Zhibing Lu; Linda Nguyen; Laurie A Reinhardt; Nigel G J Richards
A structural element that facilitates proton-coupled electron transfer in oxalate decarboxylase.
Biochemistry 2012;51(13):2911-20.
2011: Mario E G Moral; Nigel G J Richards; Chingkuang Tu; David N Silverman
Membrane inlet for mass spectrometric measurement of catalysis by enzymatic decarboxylases.
Analytical biochemistry 2011;418(1):73-7.
2011: Nabil K Thalji; Ammon B Peck; Nigel G J Richards; Benjamin K Canales
Enzymatic dissolution of calcium and struvite crystals: in vitro evaluation of biochemical requirements.
Urology 2011;78(3):721.e13-721.e17.
2011: Patricia Moussatche; Alexander Angerhofer; Witcha Imaram; Eric Hoffer; Kelsey Uberto; Christopher Brooks; Crystal Bruce; Daniel Sledge; Nigel G J Richards; Ellen W Moomaw
Characterization of Ceriporiopsis subvermispora bicupin oxalate oxidase expressed in Pichia pastoris.
Archives of biochemistry and biophysics 2011;509(1):100-7.
2011: Witcha Imaram; Benjamin T Saylor; Christopher P Centonze; Nigel G J Richards; Alexander Angerhofer
EPR spin trapping of an oxalate-derived free radical in the oxalate decarboxylase reaction.
Free radical biology & medicine 2011;50(8):1009-15.
2011: Mario E G Moral; Chingkuang Tu; Witcha Imaram; Alexander Angerhofer; David N Silverman; Nigel G J Richards
Nitric oxide reversibly inhibits Bacillus subtilis oxalate decarboxylase.
Chemical communications (Cambridge, England) 2011;47(11):3111-3.
2010: Megan E Meyer; Jemy A Gutierrez; Frank M Raushel; Nigel G J Richards
A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase.
Biochemistry 2010;49(43):9391-401.
2010: Sangbae Lee; Mengen Chen; Wei Yang; Nigel G J Richards
Sampling long time scale protein motions: OSRW simulation of active site loop conformational free energies in formyl-CoA:oxalate CoA transferase.
Journal of the American Chemical Society 2010;132(21):7252-3.
2009: Xiang Wang; Adrian E Roitberg; Nigel G J Richards
Computational studies of ammonia channel function in glutamine 5'-phosphoribosylpyrophosphate amidotransferase.
Biochemistry 2009;48(51):12272-82.
2009: Hideyuki Ikeuchi; Megan E Meyer; Yun Ding; Jun Hiratake; Nigel G J Richards
A critical electrostatic interaction mediates inhibitor recognition by human asparagine synthetase.
Bioorganic & medicinal chemistry 2009;17(18):6641-50.
2009: Ellen W Moomaw; Alexander Angerhofer; Patricia Moussatche; Andrew Ozarowski; Inés García-Rubio; Nigel G J Richards
Metal dependence of oxalate decarboxylase activity.
Biochemistry 2009;48(26):6116-25.
2008: Susan E Abbatiello; Yuan-Xiang Pan; Mi Zhou; ALAN WAYNE; Timothy D Veenstra; Stephen P Hunger; Michael S Kilberg; John R Eyler; Nigel G J Richards; Thomas P Conrads
Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients.
Journal of proteomics 2008;71(1):61-70.
2008: Nigel G J Richards
Shining a light on post-translational modification.
HFSP journal 2008;2(2):57-60.
2008: Cory G Toyota; Catrine L Berthold; Arnaud Gruez; Stefán Jónsson; Ylva Lindqvist; Christian Cambillau; Nigel G J Richards
Differential substrate specificity and kinetic behavior of Escherichia coli YfdW and Oxalobacter formigenes formyl coenzyme A transferase.
Journal of bacteriology 2008;190(7):2556-64.
2008: Catrine L Berthold; Cory G Toyota; Nigel G J Richards; Ylva Lindqvist
Reinvestigation of the catalytic mechanism of formyl-CoA transferase, a class III CoA-transferase.
The Journal of biological chemistry 2008;283(10):6519-29.
2007: Drazenka Svedruzić; Yong Liu; Laurie Reinhardt; Ewa Wroclawska; W Wallace Cleland; Nigel G J Richards
Investigating the roles of putative active site residues in the oxalate decarboxylase from Bacillus subtilis.
Archives of biochemistry and biophysics 2007;464(1):36-47.
2007: Piet Th van Duijnen; Shannon N Greene; Nigel G J Richards
Time-dependent density functional theory/discrete reaction field spectra of open shell systems: The visual spectrum of [FeIII(PyPepS)2]- in aqueous solution.
The Journal of chemical physics 2007;127(4):045105.
2007: Catrine L Berthold; Cory G Toyota; Patricia Moussatche; Martin D Wood; Finian Leeper; Nigel G J Richards; Ylva Lindqvist
Crystallographic snapshots of oxalyl-CoA decarboxylase give insights into catalysis by nonoxidative ThDP-dependent decarboxylases.
Structure (London, England : 1993) 2007;15(7):853-61.
2007: Alexander Angerhofer; Ellen W Moomaw; Inés García-Rubio; Andrew Ozarowski; J Krzystek; Ralph T Weber; Nigel G J Richards
Multifrequency EPR studies on the Mn(II) centers of oxalate decarboxylase.
The journal of physical chemistry. B 2007;111(19):5043-6.
2007: Kai Li; William T Beeson; Ion Ghiviriga; Nigel G J Richards
A convenient gHMQC-based NMR assay for investigating ammonia channeling in glutamine-dependent amidotransferases: studies of Escherichia coli asparagine synthetase B.
Biochemistry 2007;46(16):4840-9.
2006: Jemy A Gutierrez; Yuan-Xiang Pan; Lukasz Koroniak; Jun Hiratake; Michael S Kilberg; Nigel G J Richards
An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line.
Chemistry & biology 2006;13(12):1339-47.
2006: Shannon N Greene; Nigel G J Richards
Electronic structure, bonding, spectroscopy and energetics of Fe-dependent nitrile hydratase active-site models.
Inorganic chemistry 2006;45(1):17-36.
2006: Nigel G J Richards; Michael S Kilberg
Asparagine synthetase chemotherapy.
Annual review of biochemistry 2006;75():629-54.
2006: Catrine L Berthold; Harmeet Sidhu; Stefano Ricagno; Nigel G J Richards; Ylva Lindqvist
Detection and characterization of merohedral twinning in crystals of oxalyl-coenzyme A decarboxylase from Oxalobacter formigenes.
Biochimica et biophysica acta 2006;1764(1):122-8.
2005: Catrine L Berthold; Patricia Moussatche; Nigel G J Richards; Ylva Lindqvist
Structural basis for activation of the thiamin diphosphate-dependent enzyme oxalyl-CoA decarboxylase by adenosine diphosphate.
The Journal of biological chemistry 2005;280(50):41645-54.
2005: Mihai Ciustea; Jemy A Gutierrez; Susan E Abbatiello; John R Eyler; Nigel G J Richards
Efficient expression, purification, and characterization of C-terminally tagged, recombinant human asparagine synthetase.
Archives of biochemistry and biophysics 2005;440(1):18-27.
2005: Xiang Wang; Nigel G J Richards
Computer-based strategy for modeling the interaction of AGRP and related peptide ligands with the AGRP-binding site of murine melanocortin receptors.
Current pharmaceutical design 2005;11(3):345-56.
2005: Drazenka Svedruzić; Stefán Jónsson; Cory G Toyota; Laurie Reinhardt; Stefano Ricagno; Ylva Lindqvist; Nigel G J Richards
The enzymes of oxalate metabolism: unexpected structures and mechanisms.
Archives of biochemistry and biophysics 2005;433(1):176-92.
2004: Christine G Joseph; Xiang Wang; Joseph W Scott; Rayna M Bauzo; Zhimin Xiang; Nigel G J Richards; Carrie Haskell-Luevano
Stereochemical studies of the monocyclic agouti-related protein (103-122) Arg-Phe-Phe residues: conversion of a melanocortin-4 receptor antagonist into an agonist and results in the discovery of a potent and selective melanocortin-1 agonist.
Journal of medicinal chemistry 2004;47(27):6702-10.
2004: Christopher H Chang; Drazenka Svedruzic; Andrew Ozarowski; Lee Walker; Gregory Yeagle; R David Britt; Alexander Angerhofer; Nigel G J Richards
EPR spectroscopic characterization of the manganese center and a free radical in the oxalate decarboxylase reaction: identification of a tyrosyl radical during turnover.
The Journal of biological chemistry 2004;279(51):52840-9.
2004: Andrzej Wilczynski; Xiang Wang; Rayna M Bauzo; Zhimin Xiang; Amanda Shaw; William J Millard; Nigel G J Richards; Arthur S Edison; Carrie Haskell-Luevano
Structural characterization and pharmacology of a potent (Cys101-Cys119, Cys110-Cys117) bicyclic agouti-related protein (AGRP) melanocortin receptor antagonist.
Journal of medicinal chemistry 2004;47(23):5662-73.
2004: Shannon N Greene; Nigel G J Richards
Theoretical investigations of the electronic structure and spectroscopy of mononuclear, non-heme [Fe-NO](6) complexes.
Inorganic chemistry 2004;43(22):7030-41.
2004: Stefan Jonsson; Stefano Ricagno; Ylva Lindqvist; Nigel G J Richards
Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes.
The Journal of biological chemistry 2004;279(34):36003-12.
2004: Andrzej Wilczynski; Xiang Wang; Christine G Joseph; Zhimin Xiang; Rayna M Bauzo; Joseph W Scott; Nicholas B Sorensen; Amanda Shaw; William J Millard; Nigel G J Richards; Carrie Haskell-Luevano
Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
Journal of medicinal chemistry 2004;47(9):2194-207.
2004: Christopher H Chang; Amy J Boone; Rodney J Bartlett; Nigel G J Richards
Toward a computational description of nitrile hydratase: studies of the ground state bonding and spin-dependent energetics of mononuclear, non-heme Fe(III) complexes.
Inorganic chemistry 2004;43(2):458-72.
2003: Lukasz Koroniak; Mihai Ciustea; Jemy A Gutierrez; Nigel G J Richards
Synthesis and characterization of an N-acylsulfonamide inhibitor of human asparagine synthetase.
Organic letters 2003;5(12):2033-6.
2003: Alan R Tesson; Thomas S Soper; Mihai Ciustea; Nigel G J Richards
Revisiting the steady state kinetic mechanism of glutamine-dependent asparagine synthetase from Escherichia coli.
Archives of biochemistry and biophysics 2003;413(1):23-31.
2003: Laurie Reinhardt; Drazenka Svedruzic; Christopher H Chang; W Wallace Cleland; Nigel G J Richards
Heavy atom isotope effects on the reaction catalyzed by the oxalate decarboxylase from Bacillus subtilis.
Journal of the American Chemical Society 2003;125(5):1244-52.
2002: Shannon N Greene; Christopher H Chang; Nigel G J Richards
The role of post-translational modification in the photoregulation of Fe-type nitrile hydratase.
Chemical communications (Cambridge, England) 2002;(20):2386-7.
2002: Yun Ding; Jianqiang Wang; Sheldon M Schuster; Nigel G J Richards
A concise synthesis of beta-asparaginyladenylate.
The Journal of organic chemistry 2002;67(12):4372-5.
2002: Holly G Schnizer; Susan K Boehlein; Jon D Stewart; Nigel G J Richards; Sheldon M Schuster
gamma-Glutamyl thioester intermediate in glutaminase reaction catalyzed by Escherichia coli asparagine synthetase B.
Methods in enzymology 2002;354():260-71.
2002: Bulent Aydogan; David T. Marshall; Steven G Swarts; James E Turner; Amy J Boone; Nigel G J Richards; Wesley E Bolch
Site-specific OH attack to the sugar moiety of DNA: a comparison of experimental data and computational simulation.
Radiation research 2002;157(1):38-44.
2001: Ramanan Thirumoorthy; Jerry Ryan Holder; Rayna M Bauzo; Nigel G J Richards; Arthur S Edison; Carrie Haskell-Luevano
Novel agouti-related-protein-based melanocortin-1 receptor antagonist.
Journal of medicinal chemistry 2001;44(24):4114-24.
2001: Y Ding; J Wang; Khalil A Abboud; Y Xu; William R Dolbier; Nigel G J Richards
Synthesis of L-4,4-difluoroglutamic acid via nucleophilic addition to a chiral aldehyde.
The Journal of organic chemistry 2001;66(19):6381-8.
2001: Susan K Boehlein; Toru Nakatsu; Jun Hiratake; Ramanan Thirumoorthy; Jon D Stewart; Nigel G J Richards; Sheldon M Schuster
Characterization of inhibitors acting at the synthetase site of Escherichia coli asparagine synthetase B.
Biochemistry 2001;40(37):11168-75.
2001: Amy J Boone; M G Cory; Michael J Scott; M C Zerner; Nigel G J Richards
Investigating the structural and electronic properties of nitrile hydratase model iron(III) complexes using projected unrestricted Hartree-Fock (PUHF) calculations.
Inorganic chemistry 2001;40(8):1837-45.
1999: Todd M Larsen; Susan K Boehlein; Sheldon M Schuster; Nigel G J Richards; James B Thoden; Hazel M Holden; Ivan Rayment
Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product.
Biochemistry 1999;38(49):16146-57.
1999: H G Schnizer; Susan K Boehlein; Jon D Stewart; Nigel G J Richards; Sheldon M Schuster
Formation and isolation of a covalent intermediate during the glutaminase reaction of a class II amidotransferase.
Biochemistry 1999;38(12):3677-82.
1999: M D Deyrup; S T Nowicki; Nigel G J Richards; DH Otero; J K Harrison; SP Baker
Structure-affinity profile of 8-hydroxycarbostyril-based agonists that dissociate slowly from the beta2-adrenoceptor.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(3):168-77.
1998: Susan K Boehlein; Jon D Stewart; ES Walworth; Ramanan Thirumoorthy; Nigel G J Richards; Sheldon M Schuster
Kinetic mechanism of Escherichia coli asparagine synthetase B.
Biochemistry 1998;37(38):13230-8.
1998: Nigel G J Richards; Sheldon M Schuster
Mechanistic issues in asparagine synthetase catalysis.
Advances in enzymology and related areas of molecular biology 1998;72():145-98.
1997: Susan K Boehlein; ES Walworth; Nigel G J Richards; Sheldon M Schuster
Mutagenesis and chemical rescue indicate residues involved in beta-aspartyl-AMP formation by Escherichia coli asparagine synthetase B.
The Journal of biological chemistry 1997;272(19):12384-92.
1996: I B Parr; Susan K Boehlein; A B Dribben; Sheldon M Schuster; Nigel G J Richards
Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs.
Journal of medicinal chemistry 1996;39(12):2367-78.
1996: Susan K Boehlein; Sheldon M Schuster; Nigel G J Richards
Glutamic acid gamma-monohydroxamate and hydroxylamine are alternate substrates for Escherichia coli asparagine synthetase B.
Biochemistry 1996;35(9):3031-7.
1996: P W Stoker; M H O'Leary; Susan K Boehlein; Sheldon M Schuster; Nigel G J Richards
Probing the mechanism of nitrogen transfer in Escherichia coli asparagine synthetase by using heavy atom isotope effects.
Biochemistry 1996;35(9):3024-30.
1994: Susan K Boehlein; Nigel G J Richards; ES Walworth; Sheldon M Schuster
Arginine 30 and asparagine 74 have functional roles in the glutamine dependent activities of Escherichia coli asparagine synthetase B.
The Journal of biological chemistry 1994;269(43):26789-95.
1994: Susan K Boehlein; Nigel G J Richards; Sheldon M Schuster
Glutamine-dependent nitrogen transfer in Escherichia coli asparagine synthetase B. Searching for the catalytic triad.
The Journal of biological chemistry 1994;269(10):7450-7.
1993: Shijie Sheng; D A Moraga-Amador; G van Heeke; R D Allison; Nigel G J Richards; Sheldon M Schuster
Glutamine inhibits the ammonia-dependent activities of two Cys-1 mutants of human asparagine synthetase through the formation of an abortive complex.
The Journal of biological chemistry 1993;268(22):16771-80.
1993: S G Jacchieri; Nigel G J Richards
Probing the influence of sequence-dependent interactions upon alpha-helix stability in alanine-based linear peptides.
Biopolymers 1993;33(6):971-84.
1993: Chingkuang Tu; J M Couton; G Van Heeke; Nigel G J Richards; David N Silverman
Kinetic analysis of a mutant (His107-->Tyr) responsible for human carbonic anhydrase II deficiency syndrome.
The Journal of biological chemistry 1993;268(7):4775-9.
1992: Nigel G J Richards; Sheldon M Schuster
An alternative mechanism for the nitrogen transfer reaction in asparagine synthetase.
FEBS letters 1992;313(2):98-102.