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Guy Richardson

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Andrei N Lukashkin; Victoria A Lukashkina; Christine Petit; Richard J Goodyear; P Kevin Legan; Ian J Russell; Thomas D Weddell; Lindsey J Welstead; Guy P Richardson
A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation.
Guy P Richardson
The Brain Prize 2012: opening the doors of auditory perception.
Kathryn Quick; Ramin Raouf; Guy P Richardson; François Rugiero; Jane E Sexton; Ruth Taylor; Jing Zhao; Joel Abramowitz; Jonathan Ashmore; Lutz Birnbaumer; James Cox; Niels Eijkelkamp; Veit Flockerzi; Andy Forge; Marc Freichel; Martine Gringhuis; Nerissa Kirkwood; Corné J Kros; John E Linley; John N Wood
TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.

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2012: Andrei N Lukashkin; Victoria A Lukashkina; Christine Petit; Richard J Goodyear; P Kevin Legan; Ian J Russell; Thomas D Weddell; Lindsey J Welstead; Guy P Richardson
A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(47):19351-6.
2012: Guy P Richardson
The Brain Prize 2012: opening the doors of auditory perception.
Trends in neurosciences 2012;35(9):524-6.
2012: Kathryn Quick; Ramin Raouf; Guy P Richardson; François Rugiero; Jane E Sexton; Ruth Taylor; Jing Zhao; Joel Abramowitz; Jonathan Ashmore; Lutz Birnbaumer; James Cox; Niels Eijkelkamp; Veit Flockerzi; Andy Forge; Marc Freichel; Martine Gringhuis; Nerissa Kirkwood; Corné J Kros; John E Linley; John N Wood
TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.
Open biology 2012;2(5):120068.
2012: Richard J Goodyear; Sherri M Jones; Andrew Forge; Louise Sharifi; Guy P Richardson
Hair bundle defects and loss of function in the vestibular end organs of mice lacking the receptor-like inositol lipid phosphatase PTPRQ.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(8):2762-72.
2011: Elisa Caberlotto; Vincent Michel; Isabelle Foucher; Amel Bahloul; Richard J Goodyear; Elise Pepermans; Nicolas Michalski; Isabelle Perfettini; Olinda Alegria-Prévot; Sébastien Chardenoux; Marcio Do Cruzeiro; Jean-Pierre Hardelin; Guy P Richardson; Paul Avan; Dominique Weil; Christine Petit
Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(14):5825-30.
2011: Jing Zheng; Katharine K Miller; Tao Yang; Michael S Hildebrand; A Eliot Shearer; Adam P DeLuca; Todd E Scheetz; Jennifer Drummond; Steve E Scherer; P Kevin Legan; Richard J Goodyear; Guy P Richardson; Mary Ann Cheatham; Richard J Smith; Peter Dallos
Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).
Proceedings of the National Academy of Sciences of the United States of America 2011;108(10):4218-23.
2011: Elisabeth Verpy; Michel Leibovici; Nicolas Michalski; Richard J Goodyear; Carine Houdon; Dominique Weil; Guy P Richardson; Christine Petit
Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.
The Journal of comparative neurology 2011;519(2):194-210.
2011: Gowri Nayak; Richard J Goodyear; P Kevin Legan; Masaharu Noda; Guy P Richardson
Evidence for multiple, developmentally regulated isoforms of Ptprq on hair cells of the inner ear.
Developmental neurobiology 2011;71(2):129-41.
2011: Kumar N Alagramam; Richard J Goodyear; Ruishuang Geng; David N Furness; Alexander F J van Aken; Walter Marcotti; Corné J Kros; Guy P Richardson
Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.
PloS one 2011;6(4):e19183.
2011: Guy P Richardson; Jacques Boutet de Monvel; Christine Petit
How the genetics of deafness illuminates auditory physiology.
Annual review of physiology 2011;73():311-34.
2010: Richard J Goodyear; P Kevin Legan; Jeffrey R Christiansen; Bei Xia; Julia Korchagina; Jonathan E Gale; Mark E Warchol; Jeffrey T Corwin; Guy P Richardson
Identification of the hair cell soma-1 antigen, HCS-1, as otoferlin.
Journal of the Association for Research in Otolaryngology : JARO 2010;11(4):573-86.
2010: Richard J Goodyear; Andrew Forge; P Kevin Legan; Guy P Richardson
Asymmetric distribution of cadherin 23 and protocadherin 15 in the kinocilial links of avian sensory hair cells.
The Journal of comparative neurology 2010;518(21):4288-97.
2010: Andrei N Lukashkin; Guy P Richardson; Ian J Russell
Multiple roles for the tectorial membrane in the active cochlea.
Hearing research 2010;266(1-2):26-35.
2010: Shin-ichiro Kitajiri; Takeshi Sakamoto; Inna A Belyantseva; Richard J Goodyear; Ruben Stepanyan; Ikuko Fujiwara; Jonathan E Bird; Sheikh Amer Riazuddin; Sheikh Riazuddin; Zubair M Ahmed; Jenny E Hinshaw; James Sellers; James R Bartles; John A Hammer; Guy P Richardson; Andrew J Griffith; Gregory I Frolenkov; Thomas B Friedman
Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing.
Cell 2010;141(5):786-98.
2009: Nicolas Michalski; Vincent Michel; Elisa Caberlotto; Gaëlle Lefèvre; Alexander F J van Aken; Jean-Yves Tinevez; Emilie Bizard; Christophe Houbron; Dominique Weil; Jean-Pierre Hardelin; Guy P Richardson; Corné J Kros; Pascal Martin; Christine Petit
Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells.
Pflügers Archiv : European journal of physiology 2009;459(1):115-30.
2008: Alexander F J van Aken; Margaret Atiba-Davies; Walter Marcotti; Richard J Goodyear; Jane E Bryant; Guy P Richardson; Konrad Noben-Trauth; Corné J Kros
TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice.
The Journal of physiology 2008;586(Pt 22):5403-18.
2008: Elisabeth Verpy; Dominique Weil; Michel Leibovici; Richard J Goodyear; Ghislaine Hamard; Carine Houdon; Gaelle M Lefèvre; Jean-Pierre Hardelin; Guy P Richardson; Paul Avan; Christine Petit
Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.
Nature 2008;456(7219):255-8.
2008: Richard J Goodyear; Jonathan E Gale; Kishani M Ranatunga; Corné J Kros; Guy P Richardson
Aminoglycoside-induced phosphatidylserine externalization in sensory hair cells is regionally restricted, rapid, and reversible.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(40):9939-52.
2008: Guy P Richardson; Andrei N Lukashkin; Ian J Russell
The tectorial membrane: one slice of a complex cochlear sandwich.
Current opinion in otolaryngology & head and neck surgery 2008;16(5):458-64.
2007: Ian J Russell; P Kevin Legan; Victoria A Lukashkina; Andrei N Lukashkin; Richard J Goodyear; Guy P Richardson
Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane.
Nature neuroscience 2007;10(2):215-23.
2007: Gowri D Nayak; Helen S K Ratnayaka; Richard J Goodyear; Guy P Richardson
Development of the hair bundle and mechanotransduction.
The International journal of developmental biology 2007;51(6-7):597-608.
2006: Kelli R Phillips; Song Tong; Richard J Goodyear; Guy P Richardson; Janet L Cyr
Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(42):10777-88.
2006: Zubair M Ahmed; Richard J Goodyear; Sheikh Amer Riazuddin; Ayala Lagziel; P Kevin Legan; Martine Behra; Shawn M Burgess; Kathryn S Lilley; Edward R Wilcox; Sheikh Riazuddin; Andrew J Griffith; Gregory I Frolenkov; Inna A Belyantseva; Guy P Richardson; Thomas B Friedman
The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(26):7022-34.
2006: Joann McGee; Richard J Goodyear; D Randy McMillan; Eric A Stauffer; Jeffrey R Holt; Kirsten G Locke; David G Birch; P Kevin Legan; Perrin C White; Edward J Walsh; Guy P Richardson
The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(24):6543-53.
2005: P Kevin Legan; Victoria A Lukashkina; Richard J Goodyear; Andrei N Lukashkin; Kristien Verhoeven; Guy Van Camp; Ian J Russell; Guy P Richardson
A deafness mutation isolates a second role for the tectorial membrane in hearing.
Nature neuroscience 2005;8(8):1035-42.
2005: Michel Leibovici; Elisabeth Verpy; Richard J Goodyear; Ingrid Zwaenepoel; Stéphane Blanchard; Sophie Lainé; Guy P Richardson; Christine Petit
Initial characterization of kinocilin, a protein of the hair cell kinocilium.
Hearing research 2005;203(1-2):144-53.
2005: Richard J Goodyear; Walter Marcotti; Corné J Kros; Guy P Richardson
Development and properties of stereociliary link types in hair cells of the mouse cochlea.
The Journal of comparative neurology 2005;485(1):75-85.
2005: Vincent Michel; Richard J Goodyear; Dominique Weil; Walter Marcotti; Isabelle Perfettini; Uwe Wolfrum; Corné J Kros; Guy P Richardson; Christine Petit
Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells.
Developmental biology 2005;280(2):281-94.
2004: Vladimir Tsuprun; Richard J Goodyear; Guy P Richardson
The structure of tip links and kinocilial links in avian sensory hair bundles.
Biophysical journal 2004;87(6):4106-12.
2004: Mikhail E Bashtanov; Richard J Goodyear; Guy P Richardson; Ian J Russell
The mechanical properties of chick (Gallus domesticus) sensory hair bundles: relative contributions of structures sensitive to calcium chelation and subtilisin treatment.
The Journal of physiology 2004;559(Pt 1):287-99.
2004: Lily Ng; Richard J Goodyear; Chad A Woods; Mark J Schneider; Edward Diamond; Guy P Richardson; Matthew W Kelley; Donald L St Germain; Valerie Anne Galton; Douglas Forrest
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3474-9.
2004: Andrei N Lukashkin; Victoria A Lukashkina; P Kevin Legan; Guy P Richardson; Ian J Russell
Role of the tectorial membrane revealed by otoacoustic emissions recorded from wild-type and transgenic Tecta(deltaENT/deltaENT) mice.
Journal of neurophysiology 2004;91(1):163-71.
2003: Richard J Goodyear; P Kevin Legan; MB Wright; Walter Marcotti; Anush Oganesian; Scott A Coats; C J Booth; Corné J Kros; Ronald A Seifert; Daniel F Bowen-Pope; Guy P Richardson
A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(27):9208-19.
2003: Richard J Goodyear; Guy P Richardson
A novel antigen sensitive to calcium chelation that is associated with the tip links and kinocilial links of sensory hair bundles.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(12):4878-87.
2003: Julia Gorelik; Andrew I Shevchuk; Gregory I Frolenkov; Ivan A Diakonov; Max J Lab; Corné J Kros; Guy P Richardson; Igor Vodyanoy; Christopher R W Edwards; David Klenerman; Yuri E Korchev
Dynamic assembly of surface structures in living cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5819-22.
2002: Richard J Goodyear; Guy P Richardson
Extracellular matrices associated with the apical surfaces of sensory epithelia in the inner ear: molecular and structural diversity.
Journal of neurobiology 2002;53(2):212-27.
2002: Jane Bryant; Richard J Goodyear; Guy P Richardson
Sensory organ development in the inner ear: molecular and cellular mechanisms.
British medical bulletin 2002;63():39-57.
2002: Corné J Kros; Walter Marcotti; Sietse M van Netten; T J Self; Richard T Libby; S D M Brown; Guy P Richardson; Karen P Steel
Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations.
Nature neuroscience 2002;5(1):41-7.
2001: J E Gale; Walter Marcotti; Helen J Kennedy; Corné J Kros; Guy P Richardson
FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(18):7013-25.
2001: Richard J Goodyear; T Kwan; Seung Ha Oh; Yehoash Raphael; Guy P Richardson
The cell adhesion molecule BEN defines a prosensory patch in the developing avian otocyst.
The Journal of comparative neurology 2001;434(3):275-88.
2000: P Kevin Legan; Victoria A Lukashkina; Richard J Goodyear; M Kössi; Ian J Russell; Guy P Richardson
A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback.
Neuron 2000;28(1):273-85.
1999: Guy P Richardson; A Forge; Corné J Kros; Walter Marcotti; D Becker; D S Williams; J Thorpe; J Fleming; S D M Brown; Karen P Steel
A missense mutation in myosin VIIA prevents aminoglycoside accumulation in early postnatal cochlear hair cells.
Annals of the New York Academy of Sciences 1999;884():110-24.
1999: Richard J Goodyear; R Gates; Andrei N Lukashkin; Guy P Richardson
Hair-cell numbers continue to increase in the utricular macula of the early posthatch chick.
Journal of neurocytology 1999;28(10-11):851-61.
1999: R P Kruger; Richard J Goodyear; P Kevin Legan; Mark E Warchol; Yehoash Raphael; Douglas A Cotanche; Guy P Richardson
The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the avian inner ear.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(12):4815-27.
1999: P Coutinho; Richard J Goodyear; P Kevin Legan; Guy P Richardson
Chick alpha-tectorin: molecular cloning and expression during embryogenesis.
Hearing research 1999;130(1-2):62-74.
1999: A Rau; P Kevin Legan; Guy P Richardson
Tectorin mRNA expression is spatially and temporally restricted during mouse inner ear development.
The Journal of comparative neurology 1999;405(2):271-80.
1998: Lut Van Laer; Egbert H Huizing; Margriet Verstreken; Diederick van Zuijlen; Jan Wauters; P J Bossuyt; Paul Van de Heyning; Wyman T McGuirt; Richard J H Smith; Patrick J Willems; P Kevin Legan; Guy P Richardson; Guy Van Camp
Nonsyndromic hearing impairment is associated with a mutation in DFNA5.
Nature genetics 1998;20(2):194-7.
1998: Kristien Verhoeven; Lut Van Laer; Karin Kirschhofer; P Kevin Legan; David Hughes; Isabelle Schatteman; Margriet Verstreken; Peter Van Hauwe; P Coucke; A Chen; Richard J H Smith; Thomas Somers; F Erwin Offeciers; Paul Van de Heyning; Guy P Richardson; Franz J Wachtler; William J Kimberling; Patrick J Willems; Paul J Govaerts; Guy Van Camp
Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment.
Nature genetics 1998;19(1):60-2.
1998: David Hughes; P Kevin Legan; Karen P Steel; Guy P Richardson
Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness.
Genomics 1998;48(1):46-51.
1997: Guy P Richardson; A Forge; Corné J Kros; J Fleming; S D M Brown; Karen P Steel
Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(24):9506-19.
1997: Gwenaelle Geleoc; george Lennan; Guy P Richardson; Corné J Kros
A quantitative comparison of mechanoelectrical transduction in vestibular and auditory hair cells of neonatal mice.
Proceedings. Biological sciences / The Royal Society 1997;264(1381):611-21.
1997: P Kevin Legan; A Rau; J N Keen; Guy P Richardson
The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system.
The Journal of biological chemistry 1997;272(13):8791-801.
1997: R Killick; Guy P Richardson
Antibodies to the sulphated, high molecular mass mouse tectorin stain hair bundles and the olfactory mucus layer.
Hearing research 1997;103(1-2):131-41.
1996: Richard J Goodyear; R Killick; P Kevin Legan; Guy P Richardson
Distribution of beta-tectorin mRNA in the early posthatch and developing avian inner ear.
Hearing research 1996;96(1-2):167-78.
1995: R Killick; P Kevin Legan; C Malenczak; Guy P Richardson
Molecular cloning of chick beta-tectorin, an extracellular matrix molecule of the inner ear.
The Journal of cell biology 1995;129(2):535-47.
1994: B Kotecha; Guy P Richardson
Ototoxicity in vitro: effects of neomycin, gentamicin, dihydrostreptomycin, amikacin, spectinomycin, neamine, spermine and poly-L-lysine.
Hearing research 1994;73(2):173-84.
1994: Alfons Rüsch; Corné J Kros; Guy P Richardson
Block by amiloride and its derivatives of mechano-electrical transduction in outer hair cells of mouse cochlear cultures.
The Journal of physiology 1994;474(1):75-86.
1992: Ian J Russell; M Kössl; Guy P Richardson
Nonlinear mechanical responses of mouse cochlear hair bundles.
Proceedings. Biological sciences / The Royal Society 1992;250(1329):217-27.
1992: R Killick; C Malenczak; Guy P Richardson
The protein composition of the avian tectorial membrane.
Hearing research 1992;64(1):21-38.
1992: Corné J Kros; Alfons Rüsch; Guy P Richardson
Mechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochlea.
Proceedings. Biological sciences / The Royal Society 1992;249(1325):185-93.
1991: Guy P Richardson; Ian J Russell
Cochlear cultures as a model system for studying aminoglycoside induced ototoxicity.
Hearing research 1991;53(2):293-311.
1990: J A Hasko; Guy P Richardson; Ian J Russell; G Shaw
Transient expression of neurofilament protein during hair cell development in the mouse cochlea.
Hearing research 1990;45(1-2):63-73.
1990: Guy P Richardson; S Bartolami; Ian J Russell
Identification of a 275-kD protein associated with the apical surfaces of sensory hair cells in the avian inner ear.
The Journal of cell biology 1990;110(4):1055-66.
1990: M Kössl; Guy P Richardson; Ian J Russell
Stereocilia bundle stiffness: effects of neomycin sulphate, A23187 and concanavalin A.
Hearing research 1990;44(2-3):217-29.
1989: Ian J Russell; Guy P Richardson; M Kössl
The responses of cochlear hair cells to tonic displacements of the sensory hair bundle.
Hearing research 1989;43(1):55-69.
1988: J A Hasko; Guy P Richardson
The ultrastructural organization and properties of the mouse tectorial membrane matrix.
Hearing research 1988;35(1):21-38.
1987: Ian J Russell; Guy P Richardson
The morphology and physiology of hair cells in organotypic cultures of the mouse cochlea.
Hearing research 1987;31(1):9-24.