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Alan Rickinson

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Human Herpesvirus 4

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Heather M Long; Laura T Morton; Gordon B Ryan; Shereen Sabbah; Rachel J M Abbott; Odette L Chagoury; Eddie James; William Kwok; Alison M Leese; Alan B Rickinson
MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.
Edwin P Hui; Hui Jia; Benjamin F Johnson; Brigette B Y Ma; Alan B Rickinson; Neil M Steven; Deborah D Stocken; Graham S Taylor; Steven Wilson; Wai-Lap Wong; Stephen L Chan; Ceri Edwards; Rosalie Ho; Anthony T C Chan
Phase I trial of recombinant modified vaccinia ankara encoding Epstein-Barr viral tumor antigens in nasopharyngeal carcinoma patients.
Gemma L Kelly; Christian Kohler; Jane Rasaiyaah; Alan B Rickinson; Rainer Spang; Julianna Stylianou; Wendy Thomas; Wenbin Wei; Ciaran Woodman; Debbie Croom-Carter; Kellam Paul; Andrew I Bell
Different patterns of Epstein-Barr virus latency in endemic Burkitt lymphoma (BL) lead to distinct variants within the BL-associated gene expression signature.

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All Publications

2013: Heather M Long; Laura T Morton; Gordon B Ryan; Shereen Sabbah; Rachel J M Abbott; Odette L Chagoury; Eddie James; William Kwok; Alison M Leese; Alan B Rickinson
MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.
The Journal of experimental medicine 2013;210(5):933-49.
2013: Edwin P Hui; Hui Jia; Benjamin F Johnson; Brigette B Y Ma; Alan B Rickinson; Neil M Steven; Deborah D Stocken; Graham S Taylor; Steven Wilson; Wai-Lap Wong; Stephen L Chan; Ceri Edwards; Rosalie Ho; Anthony T C Chan
Phase I trial of recombinant modified vaccinia ankara encoding Epstein-Barr viral tumor antigens in nasopharyngeal carcinoma patients.
Cancer research 2013;73(6):1676-88.
2013: Gemma L Kelly; Christian Kohler; Jane Rasaiyaah; Alan B Rickinson; Rainer Spang; Julianna Stylianou; Wendy Thomas; Wenbin Wei; Ciaran Woodman; Debbie Croom-Carter; Kellam Paul; Andrew I Bell
Different patterns of Epstein-Barr virus latency in endemic Burkitt lymphoma (BL) lead to distinct variants within the BL-associated gene expression signature.
Journal of virology 2013;87(5):2882-94.
2013: Alan B Rickinson; Christopher P Fox
Epstein-Barr virus and infectious mononucleosis: what students can teach us.
The Journal of infectious diseases 2013;207(1):6-8.
2012: Denis Glotz; Maria C R Castro; Jeremy R Chapman; Vikas R Dharnidharka; Douglas W Hanto; Hans H Hirsch; Véronique Leblond; Aneesh K Mehta; Bruno Moulin; Antonio Pagliuca; Julio Pascual; Alan B Rickinson; Francesco P Russo; Ralf U Trappe; Angela C Webster; Andreas O Zuckermann; Thomas G Gross
The Seville expert workshop for progress in posttransplant lymphoproliferative disorders.
Transplantation 2012;94(8):784-93.
2012: Umaimainthan Palendira; Tri Giang Phan; Alan B Rickinson; D Sean Riminton; Joanne M Smart; Rachel J M Abbott; Stephen Adelstein; Frank Alvaro; Andrew I Bell; Rebecca H Buckley; Sharon Choo; Silvia Giliani; Bodo Grimbacher; Amy D Klion; Vassilios Lougaris; Carol Low; Cindy S Ma; Kim E Nichols; Stuart G Tangye
Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus.
The Journal of experimental medicine 2012;209(5):913-24.
2012: Emily Heath; Dieter Kube; Alan B Rickinson; Claire Shannon-Lowe; Sridhar Chaganti; Debbie Croom-Carter; Henri-Jacques Delecluse; Regina Feederle; Noelia Begue-Pastor; Andrew I Bell
Epstein-Barr virus infection of naïve B cells in vitro frequently selects clones with mutated immunoglobulin genotypes: implications for virus biology.
PLoS pathogens 2012;8(5):e1002697.
2011: Rosemary J Tierney; Kuan-Yu Kao; Jasdeep Nagra; Alan B Rickinson
Epstein-Barr virus BamHI W repeat number limits EBNA2/EBNA-LP coexpression in newly infected B cells and the efficiency of B-cell transformation: a rationale for the multiple W repeats in wild-type virus strains.
Journal of virology 2011;85(23):12362-75.
2011: Umaimainthan Palendira; Tri Giang Phan; Alan B Rickinson; D Sean Riminton; Frank Alvaro; Claire Booth; Anna Chan; Sharon Choo; Matthew C Cook; Elissa Deenick; H Bobby Gaspar; Andrew D Hislop; Edwin Ho; Rajiv Khanna; Richard Loh; Carol Low; Alessandro Moretta; Stuart G Tangye
Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.
PLoS biology 2011;9(11):e1001187.
2011: Sven H Petersen; Alan B Rickinson; Graham S Taylor; Tracey A Haigh; Elena Odintsova; Fedor Berditchevski
The role of tetraspanin CD63 in antigen presentation via MHC class II.
European journal of immunology 2011;41(9):2556-61.
2011: Heather M Long; Jared Quarcoopome; Laura L Quinn; Odette L Chagoury; Shawn R Connerty; Alison M Leese; Claire Shannon-Lowe; Alan B Rickinson
Cytotoxic CD4+ T cell responses to EBV contrast with CD8 responses in breadth of lytic cycle antigen choice and in lytic cycle recognition.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):92-101.
2011: Akihisa Sawada; Debbie Croom-Carter; Osamu Kondo; Masahiro Yasui; Maho Koyama-Sato; Masami Inoue; Keisei Kawa; Alan B Rickinson; Rosemary J Tierney
Epstein-Barr virus latent gene sequences as geographical markers of viral origin: unique EBNA3 gene signatures identify Japanese viruses as distinct members of the Asian virus family.
The Journal of general virology 2011;92(Pt 5):1032-43.
2011: Heather M Long; Graham S Taylor; Alan B Rickinson
Immune defence against EBV and EBV-associated disease.
Current opinion in immunology 2011;23(2):258-64.
2011: Daniëlle Horst; Vincenzo Favaloro; Fabio Vilardi; Hans C van Leeuwen; Malgorzata A Garstka; Andrew D Hislop; Catherine Rabu; Elisabeth Kremmer; Alan B Rickinson; Stephen High; Bernhard Dobberstein; Maaike E Ressing; Emmanuel J H J Wiertz
EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(6):3594-605.
2010: Christopher P Fox; Tracey A Haigh; Graham S Taylor; Heather M Long; Steven P Lee; Claire Shannon-Lowe; Simon O'Connor; Catherine M Bollard; Javeed Iqbal; Wing C Chan; Alan B Rickinson; Andrew I Bell; Martin Rowe
A novel latent membrane 2 transcript expressed in Epstein-Barr virus-positive NK- and T-cell lymphoproliferative disease encodes a target for cellular immunotherapy.
Blood 2010;116(19):3695-704.
2010: Andrew D Hislop; Umaimainthan Palendira; Alison M Leese; Peter D Arkwright; Pierre S Rohrlich; Stuart G Tangye; H Bobby Gaspar; Arjan C Lankester; Alessandro Moretta; Alan B Rickinson
Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets.
Blood 2010;116(17):3249-57.
2010: Christopher P Fox; Alan B Rickinson
EBV meets its match.
Blood 2010;115(5):920-1.
2010: Carol S Leung; Tracey A Haigh; Laura K Mackay; Alan B Rickinson; Graham S Taylor
Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2165-70.
2009: Laura K Mackay; Heather M Long; Jill M Brooks; Graham S Taylor; Carol S Leung; Adrienne Chen; Fred Wang; Alan B Rickinson
T cell detection of a B-cell tropic virus infection: newly-synthesised versus mature viral proteins as antigen sources for CD4 and CD8 epitope display.
PLoS pathogens 2009;5(12):e1000699.
2009: Martin Rowe; Gemma L Kelly; Andrew I Bell; Alan B Rickinson
Burkitt's lymphoma: the Rosetta Stone deciphering Epstein-Barr virus biology.
Seminars in cancer biology 2009;19(6):377-88.
2009: Delphine Sauce; Martin Larsen; Rachel J M Abbott; Andrew D Hislop; Alison M Leese; Naeem Khan; Laura Papagno; Gordon J Freeman; Alan B Rickinson
Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection.
Journal of virology 2009;83(18):9068-78.
2009: Claire Shannon-Lowe; Emily Adland; Andrew I Bell; Henri-Jacques Delecluse; Alan B Rickinson; Martin Rowe
Features distinguishing Epstein-Barr virus infections of epithelial cells and B cells: viral genome expression, genome maintenance, and genome amplification.
Journal of virology 2009;83(15):7749-60.
2009: Heather M Long; Jianmin Zuo; Alison M Leese; Nancy H Gudgeon; Hui Jia; Graham S Taylor; Alan B Rickinson
CD4+ T-cell clones recognizing human lymphoma-associated antigens: generation by in vitro stimulation with autologous Epstein-Barr virus-transformed B cells.
Blood 2009;114(4):807-15.
2009: Sridhar Chaganti; Emily M Heath; Wolfgang Bergler; Michael Kuo; Maike Buettner; Gerald Niedobitek; Alan B Rickinson; Andrew I Bell
Epstein-Barr virus colonization of tonsillar and peripheral blood B-cell subsets in primary infection and persistence.
Blood 2009;113(25):6372-81.
2009: Nathan P Croft; Claire Shannon-Lowe; Andrew I Bell; Daniëlle Horst; Elisabeth Kremmer; Maaike E Ressing; Emmanuel J H J Wiertz; Jaap Middeldorp; Martin Rowe; Alan B Rickinson; Andrew D Hislop
Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle.
PLoS pathogens 2009;5(6):e1000490.
2009: Gemma L Kelly; Heather M Long; Julianna Stylianou; Wendy A Thomas; Alison Leese; Andrew I Bell; Georg W Bornkamm; Josef Mautner; Alan B Rickinson; Martin Rowe
An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp/BHRF1 link.
PLoS pathogens 2009;5(3):e1000341.
2009: Daniëlle Horst; Daphne van Leeuwen; Nathan P Croft; Malgorzata A Garstka; Andrew D Hislop; Elisabeth Kremmer; Alan B Rickinson; Emmanuel J H J Wiertz; Maaike E Ressing
Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):2313-24.
2009: Jill M Brooks; Steven P Lee; Alison M Leese; Wendy A Thomas; Martin Rowe; Alan B Rickinson
Cyclical expression of EBV latent membrane protein 1 in EBV-transformed B cells underpins heterogeneity of epitope presentation and CD8+ T cell recognition.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):1919-28.
2009: Zania Stamataki; Claire Shannon-Lowe; Jean Shaw; David Mutimer; Alan B Rickinson; John Gordon; David H Adams; Peter Balfe; Jane A McKeating
Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells.
Blood 2009;113(3):585-93.
2008: Umaimainthan Palendira; Rosanna Chinn; Wajid Raza; Karen P Piper; Guy Pratt; Lee Machado; Andrew Bell; Naeem Khan; Andrew D Hislop; Richard Steyn; Alan B Rickinson; Christopher D Buckley; Paul Moss
Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow.
Blood 2008;112(8):3293-302.
2008: Sridhar Chaganti; Cindy S Ma; Andrew I Bell; Debbie Croom-Carter; Andrew D Hislop; Stuart G Tangye; Alan B Rickinson
Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM+IgD+CD27+ B cells harbor the virus in X-linked lymphoproliferative disease patients.
Blood 2008;112(3):672-9.
2008: Xiaorong Lin; Nancy H Gudgeon; Edwin P Hui; Hui Jia; Xue Qun; Graham S Taylor; Martin C N M Barnardo; C Kit Lin; Alan B Rickinson; Anthony T C Chan
CD4 and CD8 T cell responses to tumour-associated Epstein-Barr virus antigens in nasopharyngeal carcinoma patients.
Cancer immunology, immunotherapy : CII 2008;57(7):963-75.
2008: Tracey A Haigh; Xiaorong Lin; Hui Jia; Edwin P Hui; Anthony T C Chan; Alan B Rickinson; Graham S Taylor
EBV latent membrane proteins (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4+ cytotoxic T cell recognition of EBV-transformed B cell lines.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1643-54.
2007: Rosemary J Tierney; Jasdeep Nagra; Isabel Hutchings; Claire Shannon-Lowe; Markus Altmann; Wolfgang Hammerschmidt; Alan B Rickinson; Andrew Bell
Epstein-Barr virus exploits BSAP/Pax5 to achieve the B-cell specificity of its growth-transforming program.
Journal of virology 2007;81(18):10092-100.
2007: Andrew D Hislop; Maaike E Ressing; Daphne van Leeuwen; Victoria A Pudney; Daniëlle Horst; Danijela Koppers-Lalic; Nathan P Croft; Jacques Neefjes; Alan B Rickinson; Emmanuel J H J Wiertz
A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates.
The Journal of experimental medicine 2007;204(8):1863-73.
2007: Julie GARIBAL; Emilie Hollville; Andrew I Bell; Gemma L Kelly; Benjamin Renouf; Yasushi Kawaguchi; Alan B Rickinson; Joëlle Wiels
Truncated form of the Epstein-Barr virus protein EBNA-LP protects against caspase-dependent apoptosis by inhibiting protein phosphatase 2A.
Journal of virology 2007;81(14):7598-607.
2007: Naeem Khan; Donna Best; Rachel Bruton; Laxman Nayak; Alan B Rickinson; Paul A H Moss
T cell recognition patterns of immunodominant cytomegalovirus antigens in primary and persistent infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4455-65.
2007: Delphine Sauce; Martin Larsen; Alison M Leese; D Millar; Naeem Khan; Andrew D Hislop; Alan B Rickinson
IL-7R alpha versus CCR7 and CD45 as markers of virus-specific CD8+ T cell differentiation: contrasting pictures in blood and tonsillar lymphoid tissue.
The Journal of infectious diseases 2007;195(2):268-78.
2007: Gemma L Kelly; Alan B Rickinson
Burkitt lymphoma: revisiting the pathogenesis of a virus-associated malignancy.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2007;():277-84.
2007: Andrew D Hislop; Graham S Taylor; Delphine Sauce; Alan B Rickinson
Cellular responses to viral infection in humans: lessons from Epstein-Barr virus.
Annual review of immunology 2007;25():587-617.
2007: Graham S Taylor; Alan B Rickinson
Antigens and autophagy: the path less travelled?
Autophagy 2007;3(1):60-2.
2006: Isabel A Hutchings; Rosemary J Tierney; Gemma L Kelly; Julianna Stylianou; Alan B Rickinson; Andrew I Bell
Methylation status of the Epstein-Barr virus (EBV) BamHI W latent cycle promoter and promoter activity: analysis with novel EBV-positive Burkitt and lymphoblastoid cell lines.
Journal of virology 2006;80(21):10700-11.
2006: Gemma L Kelly; Anne E Milner; Gouri S Baldwin; Andrew I Bell; Alan B Rickinson
Three restricted forms of Epstein-Barr virus latency counteracting apoptosis in c-myc-expressing Burkitt lymphoma cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14935-40.
2006: Andrew I Bell; Katherine Groves; Gemma L Kelly; Debbie Croom-Carter; Edwin Hui; Anthony T C Chan; Alan B Rickinson
Analysis of Epstein-Barr virus latent gene expression in endemic Burkitt's lymphoma and nasopharyngeal carcinoma tumour cells by using quantitative real-time PCR assays.
The Journal of general virology 2006;87(Pt 10):2885-90.
2006: Graham S Taylor; Heather M Long; Tracey A Haigh; Martin Larsen; Jill Brooks; Alan B Rickinson
A role for intercellular antigen transfer in the recognition of EBV-transformed B cell lines by EBV nuclear antigen-specific CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3746-56.
2006: CW Tsang; X Lin; Nancy H Gudgeon; Graham S Taylor; H Jia; E P Hui; Anthony T C Chan; C K Lin; Alan B Rickinson
CD4+ T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes.
Journal of virology 2006;80(16):8263-6.
2006: Delphine Sauce; Martin Larsen; S John Curnow; Alison M Leese; Paul A H Moss; Andrew D Hislop; Mike Salmon; Alan B Rickinson
EBV-associated mononucleosis leads to long-term global deficit in T-cell responsiveness to IL-15.
Blood 2006;108(1):11-8.
2006: Claire Shannon-Lowe; Bernhard Neuhierl; Gouri Baldwin; Alan B Rickinson; Henri-Jacques Delecluse
Resting B cells as a transfer vehicle for Epstein-Barr virus infection of epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):7065-70.
2006: Rosemary J Tierney; Rachel H Edwards; Diane Sitki-Green; Debbie Croom-Carter; Sushmita Roy; Qing-yun Yao; Nancy Raab-Traub; Alan B Rickinson
Multiple Epstein-Barr virus strains in patients with infectious mononucleosis: comparison of ex vivo samples with in vitro isolates by use of heteroduplex tracking assays.
The Journal of infectious diseases 2006;193(2):287-97.
2005: Sridhar Chaganti; Andrew I Bell; Noelia Begue Pastor; Anne E Milner; Mark T Drayson; John Gordon; Alan B Rickinson
Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes.
Blood 2005;106(13):4249-52.
2005: Claire Shannon-Lowe; Gouri Baldwin; Regina Feederle; Andrew Bell; Alan B Rickinson; Henri-Jacques Delecluse
Epstein-Barr virus-induced B-cell transformation: quantitating events from virus binding to cell outgrowth.
The Journal of general virology 2005;86(Pt 11):3009-19.
2005: Robert Thimme; Victor Appay; Marie Koschella; Elisabeth Panther; Evelyn Roth; Andrew D Hislop; Alan B Rickinson; Sarah L Rowland-Jones; Hubert E Blum; Hanspeter Pircher
Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.
Journal of virology 2005;79(18):12112-6.
2005: Andrew D Hislop; Michael Kuo; Adrian B Drake-Lee; Arne N Akbar; Wolfgang Bergler; Nicolas Hammerschmitt; Naeem Khan; Umaimainthan Palendira; Alison M Leese; Judith M Timms; Andrew I Bell; Christopher D Buckley; Alan B Rickinson
Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance.
The Journal of clinical investigation 2005;115(9):2546-55.
2005: Gemma L Kelly; Anne E Milner; Rosemary J Tierney; Debbie Croom-Carter; Markus Altmann; Wolfgang Hammerschmidt; Andrew I Bell; Alan B Rickinson
Epstein-Barr virus nuclear antigen 2 (EBNA2) gene deletion is consistently linked with EBNA3A, -3B, and -3C expression in Burkitt's lymphoma cells and with increased resistance to apoptosis.
Journal of virology 2005;79(16):10709-17.
2005: Richard D Antrobus; Naeem Khan; Andrew D Hislop; Damien Montamat-Sicotte; Lee I Garner; Alan B Rickinson; Paul A H Moss; Benjamin E Willcox
Virus-specific cytotoxic T lymphocytes differentially express cell-surface leukocyte immunoglobulin-like receptor-1, an inhibitory receptor for class I major histocompatibility complex molecules.
The Journal of infectious diseases 2005;191(11):1842-53.
2005: Nancy H Gudgeon; Graham S Taylor; Heather M Long; Tracey A Haigh; Alan B Rickinson
Regression of Epstein-Barr virus-induced B-cell transformation in vitro involves virus-specific CD8+ T cells as the principal effectors and a novel CD4+ T-cell reactivity.
Journal of virology 2005;79(9):5477-88.
2005: Heather M Long; Tracey A Haigh; Nancy H Gudgeon; Ann Leen; CW Tsang; J Brooks; Elise Landais; Elisabeth Houssaint; Steven P Lee; Alan B Rickinson; Graham S Taylor
CD4+ T-cell responses to Epstein-Barr virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell lines.
Journal of virology 2005;79(8):4896-907.
2005: Naeem Khan; Rachel Bruton; Graham S Taylor; Mark Cobbold; Thomas R Jones; Alan B Rickinson; Paul A H Moss
Identification of cytomegalovirus-specific cytotoxic T lymphocytes in vitro is greatly enhanced by the use of recombinant virus lacking the US2 to US11 region or modified vaccinia virus Ankara expressing individual viral genes.
Journal of virology 2005;79(5):2869-79.
2005: Victoria A Pudney; Alison M Leese; Alan B Rickinson; Andrew D Hislop
CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells.
The Journal of experimental medicine 2005;201(3):349-60.
2005: Paul Moss; Alan B Rickinson
Cellular immunotherapy for viral infection after HSC transplantation.
Nature reviews. Immunology 2005;5(1):9-20.
2005: Seran C Hill; Sarah J Youde; Stephen Man; Glyn R Teale; Amanda J Baxendale; Andrew D Hislop; Clare C Davies; David M Luesley; Anna M Blom; Alan B Rickinson; Lawrence S Young; Aristides G Eliopoulos
Activation of CD40 in cervical carcinoma cells facilitates CTL responses and augments chemotherapy-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):41-50.
2004: Naeem Khan; Andrew D Hislop; Nancy H Gudgeon; Mark Cobbold; Rajiv Khanna; Laxman Nayak; Alan B Rickinson; Paul A H Moss
Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7481-9.
2004: Lawrence S Young; Alan B Rickinson
Epstein-Barr virus: 40 years on.
Nature reviews. Cancer 2004;4(10):757-68.
2004: Steven P Lee; Jill M Brooks; Hatim Al-Jarrah; Wendy A Thomas; Tracey A Haigh; Graham S Taylor; Sibille Humme; Aloys Schepers; Wolfgang Hammerschmidt; John L Yates; Alan B Rickinson; Neil Blake
CD8 T cell recognition of endogenously expressed epstein-barr virus nuclear antigen 1.
The Journal of experimental medicine 2004;199(10):1409-20.
2004: Graham S Taylor; Tracey A Haigh; Nancy H Gudgeon; R J Phelps; Steven P Lee; Neil M Steven; Alan B Rickinson
Dual stimulation of Epstein-Barr Virus (EBV)-specific CD4+- and CD8+-T-cell responses by a chimeric antigen construct: potential therapeutic vaccine for EBV-positive nasopharyngeal carcinoma.
Journal of virology 2004;78(2):768-78.
2003: Andrew Bell; Alan B Rickinson
Epstein-Barr virus, the TCL-1 oncogene and Burkitt's lymphoma.
Trends in microbiology 2003;11(11):495-7.
2003: Rachel S Midgley; Andrew I Bell; D J McGeoch; Alan B Rickinson
Latent gene sequencing reveals familial relationships among Chinese Epstein-Barr virus strains and evidence for positive selection of A11 epitope changes.
Journal of virology 2003;77(21):11517-30.
2003: Rachel S Midgley; Andrew I Bell; Qing-yun Yao; Debbie Croom-Carter; Andrew D Hislop; B M Whitney; Anthony T C Chan; P J Johnson; Alan B Rickinson
HLA-A11-restricted epitope polymorphism among Epstein-Barr virus strains in the highly HLA-A11-positive Chinese population: incidence and immunogenicity of variant epitope sequences.
Journal of virology 2003;77(21):11507-16.
2003: Elisabeth Amyes; Chris Hatton; Damien Montamat-Sicotte; Nancy H Gudgeon; Alan B Rickinson; Andrew J McMichael; Margaret F C Callan
Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.
The Journal of experimental medicine 2003;198(6):903-11.
2003: Suparno Chakrabarti; Donald W Milligan; Deenan Pillay; Stephen Mackinnon; Kathleen Holder; Narinder Kaur; Dorothy McDonald; Christopher Fegan; Herman Waldmann; Geoff Hale; Alan B Rickinson; Neil M Steven
Reconstitution of the Epstein-Barr virus-specific cytotoxic T-lymphocyte response following T-cell-depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation.
Blood 2003;102(3):839-42.
2003: Pauline Meij; Joost W J van Esser; Hubert G M Niesters; Debbie Van Baarle; Frank Miedema; Neil Blake; Alan B Rickinson; Ingrid Leiner; Eric G Pamer; Bob Lowenberg; Jan J Cornelissen; Jan W Gratama
Impaired recovery of Epstein-Barr virus (EBV)--specific CD8+ T lymphocytes after partially T-depleted allogeneic stem cell transplantation may identify patients at very high risk for progressive EBV reactivation and lymphoproliferative disease.
Blood 2003;101(11):4290-7.
2003: Georg Lautscham; Alan B Rickinson; Neil Blake
TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein-Barr virus.
Microbes and infection / Institut Pasteur 2003;5(4):291-9.
2003: Georg Lautscham; Tracey A Haigh; Sabine Mayrhofer; Graham Taylor; Debbie Croom-Carter; Alison M Leese; Stephan D Gadola; Vincenzo Cerundolo; Alan B Rickinson; Neil Blake
Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2.
Journal of virology 2003;77(4):2757-61.
2003: Judith M Timms; Andrew Bell; Joanne R Flavell; Paul G Murray; Alan B Rickinson; Alexandra Traverse-Glehen; Françoise Berger; Henri-Jacques Delecluse
Target cells of Epstein-Barr-virus (EBV)-positive post-transplant lymphoproliferative disease: similarities to EBV-positive Hodgkin's lymphoma.
Lancet 2003;361(9353):217-23.
2002: Chen-Lung Lin; Wei-Feng Lo; Tzong-Hsien Lee; Yi Ren; Shiuh-Lin Hwang; Yu Fan Cheng; Chao-Long Chen; Yu-Sen Chang; Steve P Lee; Alan B Rickinson; Paul K H Tam
Immunization with Epstein-Barr Virus (EBV) peptide-pulsed dendritic cells induces functional CD8+ T-cell immunity and may lead to tumor regression in patients with EBV-positive nasopharyngeal carcinoma.
Cancer research 2002;62(23):6952-8.
2002: Gemma Kelly; Andrew Bell; Alan B Rickinson
Epstein-Barr virus-associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2.
Nature medicine 2002;8(10):1098-104.
2002: Andreas Moosmann; Naeem Khan; Mark Cobbold; Caroline Zentz; Henri-Jacques Delecluse; Gabi Hollweck; Andrew D Hislop; Neil Blake; Debbie Croom-Carter; Barbara Wollenberg; Paul A H Moss; Reinhard Zeidler; Alan B Rickinson; Wolfgang Hammerschmidt
B cells immortalized by a mini-Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cells.
Blood 2002;100(5):1755-64.
2002: Padraic J Dunne; Jeff M Faint; Nancy H Gudgeon; Jean M Fletcher; Fiona J Plunkett; Maria Soares; Andrew D Hislop; Nicola E Annels; Alan B Rickinson; Mike Salmon; Arne N Akbar
Epstein-Barr virus-specific CD8(+) T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential.
Blood 2002;100(3):933-40.
2002: Bruce M Whitney; Anthony T C Chan; Alan B Rickinson; Steven P Lee; C K Lin; Philip J Johnson
Frequency of Epstein-Barr virus-specific cytotoxic T lymphocytes in the blood of Southern Chinese blood donors and nasopharyngeal carcinoma patients.
Journal of medical virology 2002;67(3):359-63.
2002: Yamina Hamel; Neil Blake; Susanne Gabrielsson; Tracey A Haigh; Karin Jooss; Chantal Martinache; Sophie Caillat-Zucman; Alan B Rickinson; Salima Hacein-Bey; Alain Fischer; Marina Cavazzana-Calvo
Adenovirally transduced dendritic cells induce bispecific cytotoxic T lymphocyte responses against adenovirus and cytomegalovirus pp65 or against adenovirus and Epstein-Barr virus EBNA3C protein: a novel approach for immunotherapy.
Human gene therapy 2002;13(7):855-66.
2002: Pauline Meij; Ann Leen; Alan B Rickinson; Saertje Verkoeijen; Marcel B H J Vervoort; Elisabeth Bloemena; Jaap Middeldorp
Identification and prevalence of CD8(+) T-cell responses directed against Epstein-Barr virus-encoded latent membrane protein 1 and latent membrane protein 2.
International journal of cancer. Journal international du cancer 2002;99(1):93-9.
2002: Martin Staege; Steven P Lee; Teresa Frisan; Josef Mautner; Siegfried Scholz; Alexander Pajic; Alan B Rickinson; Maria Masucci; Axel Polack; Georg W Bornkamm
MYC overexpression imposes a nonimmunogenic phenotype on Epstein-Barr virus-infected B cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4550-5.
2002: Andrew D Hislop; Nicola E Annels; Nancy H Gudgeon; Alison M Leese; Alan B Rickinson
Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infection.
The Journal of experimental medicine 2002;195(7):893-905.
2002: Alan B Rickinson
Epstein-Barr virus.
Virus research 2002;82(1-2):109-13.
2001: E M McCann; Gemma L Kelly; Alan B Rickinson; Andrew I Bell
Genetic analysis of the Epstein-Barr virus-coded leader protein EBNA-LP as a co-activator of EBNA2 function.
The Journal of general virology 2001;82(Pt 12):3067-79.
2001: R S Harris; Debbie Croom-Carter; Alan B Rickinson; Michael S Neuberger
Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells.
Journal of virology 2001;75(21):10488-92.
2001: Georg Lautscham; S Mayrhofer; G Taylor; Tracey A Haigh; Alison M Leese; Alan B Rickinson; Neil Blake
Processing of a multiple membrane spanning Epstein-Barr virus protein for CD8(+) T cell recognition reveals a proteasome-dependent, transporter associated with antigen processing-independent pathway.
The Journal of experimental medicine 2001;194(8):1053-68.
2001: Ann Leen; Pauline Meij; IV Redchenko; Jaap Middeldorp; Elisabeth Bloemena; Alan B Rickinson; Neil Blake
Differential immunogenicity of Epstein-Barr virus latent-cycle proteins for human CD4(+) T-helper 1 responses.
Journal of virology 2001;75(18):8649-59.
2001: A L Chapman; Alan B Rickinson; Wendy A Thomas; R F Jarrett; John Crocker; Steven P Lee
Epstein-Barr virus-specific cytotoxic T lymphocyte responses in the blood and tumor site of Hodgkin's disease patients: implications for a T-cell-based therapy.
Cancer research 2001;61(16):6219-26.
2001: Andrew D Hislop; Nancy H Gudgeon; Margaret F C Callan; Chrysa Fazou; H Hasegawa; Mike Salmon; Alan B Rickinson
EBV-specific CD8+ T cell memory: relationships between epitope specificity, cell phenotype, and immediate effector function.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2019-29.
2001: Jeff M Faint; Nicola E Annels; S John Curnow; P Shields; Darrell Pilling; Andrew D Hislop; L Wu; Arne N Akbar; Christopher D Buckley; Paul A H Moss; David H Adams; Alan B Rickinson; Mike Salmon
Memory T cells constitute a subset of the human CD8+CD45RA+ pool with distinct phenotypic and migratory characteristics.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):212-20.
2001: Alan B Rickinson
Concluding overview: looking back, looking forward.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1408):595-604.
2001: Fiona J Plunkett; Maria Soares; Nicola E Annels; Andrew D Hislop; K Ivory; Mark W Lowdell; Mike Salmon; Alan B Rickinson; Arne N Akbar
The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection.
Blood 2001;97(3):700-7.
2000: Neil Blake; Tracey A Haigh; G Shaka'a; Debbie Croom-Carter; Alan B Rickinson
The importance of exogenous antigen in priming the human CD8+ T cell response: lessons from the EBV nuclear antigen EBNA1.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7078-87.
2000: Mala K Maini; Nancy H Gudgeon; Lucy R Wedderburn; Alan B Rickinson; Peter C L Beverley
Clonal expansions in acute EBV infection are detectable in the CD8 and not the CD4 subset and persist with a variable CD45 phenotype.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5729-37.
2000: Nicola E Annels; Margaret F C Callan; L Tan; Alan B Rickinson
Changing patterns of dominant TCR usage with maturation of an EBV-specific cytotoxic T cell response.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4831-41.
2000: Rosemary J Tierney; HE Kirby; Jasdeep Nagra; J Desmond; Andrew I Bell; Alan B Rickinson
Methylation of transcription factor binding sites in the Epstein-Barr virus latent cycle promoter Wp coincides with promoter down-regulation during virus-induced B-cell transformation.
Journal of virology 2000;74(22):10468-79.
2000: Rosemary J Tierney; HE Kirby; Jasdeep Nagra; Alan B Rickinson; Andrew Bell
The Epstein-Barr virus promoter initiating B-cell transformation is activated by RFX proteins and the B-cell-specific activator protein BSAP/Pax5.
Journal of virology 2000;74(22):10458-67.
2000: V L Crotzer; Robert E Christian; Jill M Brooks; Jeffrey Shabanowitz; Robert E Settlage; Jarrod A Marto; Forest M White; Alan B Rickinson; Donald F Hunt; Victor H Engelhard
Immunodominance among EBV-derived epitopes restricted by HLA-B27 does not correlate with epitope abundance in EBV-transformed B-lymphoblastoid cell lines.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6120-9.
2000: HE Kirby; Alan B Rickinson; Andrew Bell
The activity of the Epstein-Barr virus BamHI W promoter in B cells is dependent on the binding of CREB/ATF factors.
The Journal of general virology 2000;81(Pt 4):1057-66.
2000: Alan B Rickinson; Margaret F C Callan; Nicola E Annels
T-cell memory: lessons from Epstein-Barr virus infection in man.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1395):391-400.
2000: Alan B Rickinson; Peter J L Lane
Epstein-Barr virus: Co-opting B-cell memory and migration.
Current biology : CB 2000;10(3):R120-3.
2000: Jill M Brooks; Debbie Croom-Carter; Alison M Leese; Rosemary J Tierney; G Habeshaw; Alan B Rickinson
Cytotoxic T-lymphocyte responses to a polymorphic Epstein-Barr virus epitope identify healthy carriers with coresident viral strains.
Journal of virology 2000;74(4):1801-9.
2000: Rachel S Midgley; Neil Blake; Qing-yun Yao; Debbie Croom-Carter; S T Cheung; S F Leung; Anthony T C Chan; P J Johnson; D Huang; Alan B Rickinson; Steven P Lee
Novel intertypic recombinants of epstein-barr virus in the chinese population.
Journal of virology 2000;74(3):1544-8.
2000: LC Tan; A G Mowat; Chrysa Fazou; Tim Rostron; H Roskell; P Rod Dunbar; C Tournay; François Romagné; Marie-Alix Peyrat; Elisabeth Houssaint; Marc Bonneville; Alan B Rickinson; Andrew J McMichael; Margaret F C Callan
Specificity of T cells in synovial fluid: high frequencies of CD8(+) T cells that are specific for certain viral epitopes.
Arthritis research 2000;2(2):154-64.
1999: Neil Blake; Amir Moghaddam; P Rao; A Kaur; R Glickman; Young-Gyu Cho; A Marchini; Tracey A Haigh; R P Johnson; Alan B Rickinson; F Wang
Inhibition of antigen presentation by the glycine/alanine repeat domain is not conserved in simian homologues of Epstein-Barr virus nuclear antigen 1.
Journal of virology 1999;73(9):7381-9.
1999: Alan B Rickinson
Targeting human tumours with antigen-specific cytotoxic T-cells.
British journal of cancer 1999;80 Suppl 1():51-6.
1999: Nico Henriquez; Eike Floettmann; Mike Salmon; Martin Rowe; Alan B Rickinson
Differential responses to CD40 ligation among Burkitt lymphoma lines that are uniformly responsive to Epstein-Barr virus latent membrane protein 1.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3298-307.
1999: LC Tan; Nancy H Gudgeon; Nicola E Annels; Pokrath Hansasuta; Christopher A O'Callaghan; Sarah Rowland-Jones; Andrew J McMichael; Alan B Rickinson; Margaret F C Callan
A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1827-35.
1999: G Habeshaw; Qing-yun Yao; Andrew I Bell; D Morton; Alan B Rickinson
Epstein-barr virus nuclear antigen 1 sequences in endemic and sporadic Burkitt's lymphoma reflect virus strains prevalent in different geographic areas.
Journal of virology 1999;73(2):965-75.
1999: IV Redchenko; Alan B Rickinson
Accessing Epstein-Barr virus-specific T-cell memory with peptide-loaded dendritic cells.
Journal of virology 1999;73(1):334-42.
1998: Andrew Bell; J Skinner; HE Kirby; Alan B Rickinson
Characterisation of regulatory sequences at the Epstein-Barr virus BamHI W promoter.
Virology 1998;252(1):149-61.
1998: Margaret F C Callan; Nicola E Annels; Neil M Steven; L Tan; J Wilson; Andrew J McMichael; Alan B Rickinson
T cell selection during the evolution of CD8+ T cell memory in vivo.
European journal of immunology 1998;28(12):4382-90.
1998: Jill M Brooks; Robert A Colbert; John P Mear; Alison M Leese; Alan B Rickinson
HLA-B27 subtype polymorphism and CTL epitope choice: studies with EBV peptides link immunogenicity with stability of the B27:peptide complex.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5252-9.
1998: Steven P Lee; CM Constandinou; Wendy A Thomas; Debbie Croom-Carter; Neil Blake; Paul G Murray; John Crocker; Alan B Rickinson
Antigen presenting phenotype of Hodgkin Reed-Sternberg cells: analysis of the HLA class I processing pathway and the effects of interleukin-10 on epstein-barr virus-specific cytotoxic T-cell recognition.
Blood 1998;92(3):1020-30.
1998: Margaret F C Callan; L Tan; Nicola E Annels; Graham S Ogg; JD Wilson; Christopher A O'Callaghan; Neil M Steven; Andrew J McMichael; Alan B Rickinson
Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo.
The Journal of experimental medicine 1998;187(9):1395-402.
1998: Qing-yun Yao; Debbie Croom-Carter; Rosemary J Tierney; G Habeshaw; Jonathan T Wilde; Frank G H Hill; C Conlon; Alan B Rickinson
Epidemiology of infection with Epstein-Barr virus types 1 and 2: lessons from the study of a T-cell-immunocompromised hemophilic cohort.
Journal of virology 1998;72(5):4352-63.
1998: Aristides G Eliopoulos; Alan B Rickinson
Epstein-Barr virus: LMP1 masquerades as an active receptor.
Current biology : CB 1998;8(6):R196-8.
1998: Jose Ramón Lamas; Jill M Brooks; Begoña Galocha; Alan B Rickinson; José A López de Castro
Relationship between peptide binding and T cell epitope selection: a study with subtypes of HLA-B27.
International immunology 1998;10(3):259-66.
1998: A L Chapman; Alan B Rickinson
Epstein-Barr virus in Hodgkin's disease.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9 Suppl 5():S5-16.
1997: Neil Blake; S Lee; IV Redchenko; W Thomas; Neil M Steven; Alison M Leese; PM Steigerwald-Mullen; Michael Kurilla; L Frappier; Alan B Rickinson
Human CD8+ T cell responses to EBV EBNA1: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing.
Immunity 1997;7(6):791-802.
1997: F Nitsche; Andrew Bell; Alan B Rickinson
Epstein-Barr virus leader protein enhances EBNA-2-mediated transactivation of latent membrane protein 1 expression: a role for the W1W2 repeat domain.
Journal of virology 1997;71(9):6619-28.
1997: Neil M Steven; Nicola E Annels; A Kumar; Alison M Leese; Michael Kurilla; Alan B Rickinson
Immediate early and early lytic cycle proteins are frequent targets of the Epstein-Barr virus-induced cytotoxic T cell response.
The Journal of experimental medicine 1997;185(9):1605-17.
1997: Steven P Lee; Rosemary J Tierney; Wendy A Thomas; Jill M Brooks; Alan B Rickinson
Conserved CTL epitopes within EBV latent membrane protein 2: a potential target for CTL-based tumor therapy.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3325-34.
1997: Alan B Rickinson; D J Moss
Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection.
Annual review of immunology 1997;15():405-31.
1996: Neil M Steven; Alison M Leese; N E Annels; Steven P Lee; Alan B Rickinson
Epitope focusing in the primary cytotoxic T cell response to Epstein-Barr virus and its relationship to T cell memory.
The Journal of experimental medicine 1996;184(5):1801-13.
1996: Farhat L Khanim; Qing-yun Yao; Gerald Niedobitek; S Sihota; Alan B Rickinson; Lawrence S Young
Analysis of Epstein-Barr virus gene polymorphisms in normal donors and in virus-associated tumors from different geographic locations.
Blood 1996;88(9):3491-501.
1996: Alan B Rickinson; Steven P Lee; Neil M Steven
Cytotoxic T lymphocyte responses to Epstein-Barr virus.
Current opinion in immunology 1996;8(4):492-7.
1996: Steven P Lee; Wendy A Thomas; N W Blake; Alan B Rickinson
Transporter (TAP)-independent processing of a multiple membrane-spanning protein, the Epstein-Barr virus latent membrane protein 2.
European journal of immunology 1996;26(8):1875-83.
1996: Qing-yun Yao; Rosemary J Tierney; D Croom-Carter; G M Cooper; C J Ellis; Martin Rowe; Alan B Rickinson
Isolation of intertypic recombinants of Epstein-Barr virus from T-cell-immunocompromised individuals.
Journal of virology 1996;70(8):4895-903.
1996: Qing-yun Yao; Rosemary J Tierney; D Croom-Carter; D Dukers; G M Cooper; C J Ellis; Martin Rowe; Alan B Rickinson
Frequency of multiple Epstein-Barr virus infections in T-cell-immunocompromised individuals.
Journal of virology 1996;70(8):4884-94.
1996: Margaret F C Callan; Neil M Steven; P Krausa; J D Wilson; P A Moss; G M Gillespie; John I Bell; Alan B Rickinson; Andrew J McMichael
Large clonal expansions of CD8+ T cells in acute infectious mononucleosis.
Nature medicine 1996;2(8):906-11.
1996: S M Morgan; G W Wilkinson; E Floettmann; N Blake; Alan B Rickinson
A recombinant adenovirus expressing an Epstein-Barr virus (EBV) target antigen can selectively reactivate rare components of EBV cytotoxic T-lymphocyte memory in vitro.
Journal of virology 1996;70(4):2394-402.
1996: P G Knox; Q X Li; Alan B Rickinson; Lawrence S Young
In vitro production of stable Epstein-Barr virus-positive epithelial cell clones which resemble the virus:cell interaction observed in nasopharyngeal carcinoma.
Virology 1996;215(1):40-50.
1996: C Nonkwelo; J Skinner; A Bell; Alan B Rickinson; Jeffery T Sample
Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein.
Journal of virology 1996;70(1):623-7.
1995: Ann B Hill; S P Lee; JS Haurum; N Murray; Q Y Yao; M Rowe; N Signoret; Alan B Rickinson; Andrew J McMichael
Class I major histocompatibility complex-restricted cytotoxic T lymphocytes specific for Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell lines against which they were raised.
The Journal of experimental medicine 1995;181(6):2221-8.
1995: Alan B Rickinson
Immune intervention against virus-associated human cancers.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6 Suppl 1():69-71.
1995: Ann B Hill; A Worth; Tim Elliott; S Rowland-Jones; J Brooks; Alan B Rickinson; Andrew McMichael
Characterization of two Epstein-Barr virus epitopes restricted by HLA-B7.
European journal of immunology 1995;25(1):18-24.
1995: Steven P Lee; S Morgan; J Skinner; Wendy A Thomas; S R Jones; J Sutton; Rajiv Khanna; H C Whittle; Alan B Rickinson
Epstein-Barr virus isolates with the major HLA B35.01-restricted cytotoxic T lymphocyte epitope are prevalent in a highly B35.01-positive African population.
European journal of immunology 1995;25(1):102-10.
1994: Rosemary J Tierney; Neil M Steven; Lawrence S Young; Alan B Rickinson
Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state.
Journal of virology 1994;68(11):7374-85.
1994: Martin Rowe; M Peng-Pilon; D S Huen; R Hardy; D Croom-Carter; E Lundgren; Alan B Rickinson
Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers.
Journal of virology 1994;68(9):5602-12.
1994: P O de Campos-Lima; Victor Levitsky; J Brooks; S P Lee; L F Hu; Alan B Rickinson; Maria Masucci
T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues.
The Journal of experimental medicine 1994;179(4):1297-305.
1993: Steven P Lee; Wendy A Thomas; R J Murray; Farhat L Khanim; S Kaur; Lawrence S Young; Martin Rowe; Michael Kurilla; Alan B Rickinson
HLA A2.1-restricted cytotoxic T cells recognizing a range of Epstein-Barr virus isolates through a defined epitope in latent membrane protein LMP2.
Journal of virology 1993;67(12):7428-35.
1993: S Henderson; D Huen; M Rowe; C Dawson; G Johnson; Alan B Rickinson
Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8479-83.
1993: Jill M Brooks; R J Murray; Wendy A Thomas; Michael Kurilla; Alan B Rickinson
Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide.
The Journal of experimental medicine 1993;178(3):879-87.
1993: L A Brooks; A L Lear; Lawrence S Young; Alan B Rickinson
Transcripts from the Epstein-Barr virus BamHI A fragment are detectable in all three forms of virus latency.
Journal of virology 1993;67(6):3182-90.
1993: Steven P Lee; L E Wallace; M Mackett; J R Arrand; Peter F Searle; Martin Rowe; Alan B Rickinson
MHC class II-restricted presentation of endogenously synthesized antigen: Epstein-Barr virus transformed B cell lines can present the viral glycoprotein gp340 by two distinct pathways.
International immunology 1993;5(5):451-60.
1993: P O de Campos-Lima; Riccardo Gavioli; Q J Zhang; L E Wallace; Riccardo Dolcetti; M Rowe; Alan B Rickinson; Maria Masucci
HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly A11+ population.
Science (New York, N.Y.) 1993;260(5104):98-100.
1993: Choon-Kook Sam; L A Brooks; Gerald Niedobitek; Lawrence S Young; U Prasad; Alan B Rickinson
Analysis of Epstein-Barr virus infection in nasopharyngeal biopsies from a group at high risk of nasopharyngeal carcinoma.
International journal of cancer. Journal international du cancer 1993;53(6):957-62.
1993: Riccardo Gavioli; Michael Kurilla; P O de Campos-Lima; L E Wallace; Riccardo Dolcetti; R J Murray; Alan B Rickinson; Maria Masucci
Multiple HLA A11-restricted cytotoxic T-lymphocyte epitopes of different immunogenicities in the Epstein-Barr virus-encoded nuclear antigen 4.
Journal of virology 1993;67(3):1572-8.
1993: E M Deacon; G Pallesen; Gerald Niedobitek; John Crocker; L Brooks; Alan B Rickinson; Lawrence S Young
Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells.
The Journal of experimental medicine 1993;177(2):339-49.
1992: A L Lear; Martin Rowe; Michael Kurilla; S Lee; S Henderson; Elliott Kieff; Alan B Rickinson
The Epstein-Barr virus (EBV) nuclear antigen 1 BamHI F promoter is activated on entry of EBV-transformed B cells into the lytic cycle.
Journal of virology 1992;66(12):7461-8.
1992: Maria Masucci; Q J Zhang; Riccardo Gavioli; P O De Campos-Lima; R J Murray; J Brooks; H Griffin; H Ploegh; Alan B Rickinson
Immune escape by Epstein-Barr virus (EBV) carrying Burkitt's lymphoma: in vitro reconstitution of sensitivity to EBV-specific cytotoxic T cells.
International immunology 1992;4(11):1283-92.
1992: H Griffin; Martin Rowe; R Murray; J Brooks; Alan B Rickinson
Restoration of the LFA-3 adhesion pathway in Burkitt's lymphoma cells using an LFA-3 recombinant vaccinia virus: consequences for T cell recognition.
European journal of immunology 1992;22(7):1741-8.
1992: R J Murray; Michael Kurilla; Jill M Brooks; Wendy A Thomas; Martin Rowe; Elliott Kieff; Alan B Rickinson
Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies.
The Journal of experimental medicine 1992;176(1):157-68.
1992: L Brooks; Qing-yun Yao; Alan B Rickinson; Lawrence S Young
Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcripts.
Journal of virology 1992;66(5):2689-97.
1992: Gerald Niedobitek; Lawrence S Young; Choon-Kook Sam; L Brooks; U Prasad; Alan B Rickinson
Expression of Epstein-Barr virus genes and of lymphocyte activation molecules in undifferentiated nasopharyngeal carcinomas.
The American journal of pathology 1992;140(4):879-87.
1992: Q X Li; Lawrence S Young; Gerald Niedobitek; Christopher W Dawson; M Birkenbach; Fred Wang; Alan B Rickinson
Epstein-Barr virus infection and replication in a human epithelial cell system.
Nature 1992;356(6367):347-50.
1992: B M Kerr; A L Lear; Martin Rowe; D Croom-Carter; Lawrence S Young; Susan M Rookes; Phillip H Gallimore; Alan B Rickinson
Three transcriptionally distinct forms of Epstein-Barr virus latency in somatic cell hybrids: cell phenotype dependence of virus promoter usage.
Virology 1992;187(1):189-201.
1992: Alan B Rickinson; R J Murray; J Brooks; H Griffin; Denis Moss; Maria Masucci
T cell recognition of Epstein-Barr virus associated lymphomas.
Cancer surveys 1992;13():53-80.
1992: Martin Rowe; A L Lear; D Croom-Carter; A H Davies; Alan B Rickinson
Three pathways of Epstein-Barr virus gene activation from EBNA1-positive latency in B lymphocytes.
Journal of virology 1992;66(1):122-31.
1991: Gerald Niedobitek; Lawrence S Young; R Lau; L Brooks; D Greenspan; John Greenspan; Alan B Rickinson
Epstein-Barr virus infection in oral hairy leukoplakia: virus replication in the absence of a detectable latent phase.
The Journal of general virology 1991;72 ( Pt 12)():3035-46.
1991: A H Davies; Roger J A Grand; F J Evans; Alan B Rickinson
Induction of Epstein-Barr virus lytic cycle by tumor-promoting and non-tumor-promoting phorbol esters requires active protein kinase C.
Journal of virology 1991;65(12):6838-44.
1991: Jeffery T Sample; L Brooks; C Sample; L Young; Martin Rowe; C Gregory; Alan B Rickinson; Elliott Kieff
Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6343-7.
1991: L E Wallace; J Wright; D O Ulaeto; Andrew J Morgan; Alan B Rickinson
Identification of two T-cell epitopes on the candidate Epstein-Barr virus vaccine glycoprotein gp340 recognized by CD4+ T-cell clones.
Journal of virology 1991;65(7):3821-8.
1991: Qing-yun Yao; Martin Rowe; B Martin; Lawrence S Young; Alan B Rickinson
The Epstein-Barr virus carrier state: dominance of a single growth-transforming isolate in the blood and in the oropharynx of healthy virus carriers.
The Journal of general virology 1991;72 ( Pt 7)():1579-90.
1991: S Henderson; Martin Rowe; C Gregory; D Croom-Carter; Fred Wang; R Longnecker; Elliott Kieff; Alan B Rickinson
Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death.
Cell 1991;65(7):1107-15.
1991: Lawrence S Young; R Lau; Martin Rowe; Gerald Niedobitek; Graham Packham; F Shanahan; D T Rowe; D Greenspan; John Greenspan; Alan B Rickinson
Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia.
Journal of virology 1991;65(6):2868-74.
1991: Qing-yun Yao; H Czarnecka; Alan B Rickinson
Spontaneous outgrowth of Epstein-Barr virus-positive B-cell lines from circulating human B cells of different buoyant densities.
International journal of cancer. Journal international du cancer 1991;48(2):253-7.
1991: Qing-yun Yao; Martin Rowe; Andrew J Morgan; Choon-Kook Sam; U Prasad; H Dang; Y Zeng; Alan B Rickinson
Salivary and serum IgA antibodies to the Epstein-Barr virus glycoprotein gp340: incidence and potential for virus neutralization.
International journal of cancer. Journal international du cancer 1991;48(1):45-50.
1991: Christopher D Gregory; C Dive; S Henderson; C A Smith; G T Williams; John Gordon; Alan B Rickinson
Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis.
Nature 1991;349(6310):612-4.
1991: Martin Rowe; Lawrence S Young; John Crocker; H Stokes; S Henderson; Alan B Rickinson
Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.
The Journal of experimental medicine 1991;173(1):147-58.
1990: Jeffery T Sample; L Young; B Martin; T Chatman; Elliott Kieff; Alan B Rickinson; E Kieff
Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes.
Journal of virology 1990;64(9):4084-92.
1990: Christopher D Gregory; Martin Rowe; Alan B Rickinson
Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line.
The Journal of general virology 1990;71 ( Pt 7)():1481-95.
1990: Fred Wang; C Gregory; C Sample; Martin Rowe; D Liebowitz; R Murray; Alan B Rickinson; Elliott Kieff
Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23.
Journal of virology 1990;64(5):2309-18.
1990: S D Abbot; Martin Rowe; K Cadwallader; Anne Ricksten; John Gordon; Fred Wang; Lars Rymo; Alan B Rickinson
Epstein-Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein.
Journal of virology 1990;64(5):2126-34.
1990: Christopher W Dawson; Alan B Rickinson; Lawrence S Young
Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation.
Nature 1990;344(6268):777-80.
1990: R J Murray; Jill M Brooks; Alan B Rickinson; Martin Rowe
Cross-recognition of a mouse H-2-peptide complex by human HLA-restricted cytotoxic T cells.
European journal of immunology 1990;20(3):659-64.
1990: Martin Rowe; Lawrence S Young; Alan B Rickinson
Analysis of Epstein-Barr virus gene expression in lymphomas derived from normal human B cells grafted into SCID mice.
Current topics in microbiology and immunology 1990;166():325-31.
1990: Alan B Rickinson
On the biology of Epstein-Barr virus persistence: a reappraisal.
Advances in experimental medicine and biology 1990;278():137-46.
1989: L Young; C Alfieri; K Hennessy; H Evans; C O'Hara; Kenneth C Anderson; Jerome Ritz; R S Shapiro; Alan B Rickinson; Elliott Kieff
Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease.
The New England journal of medicine 1989;321(16):1080-5.
1989: Lawrence S Young; Christopher W Dawson; K W Brown; Alan B Rickinson
Identification of a human epithelial cell surface protein sharing an epitope with the C3d/Epstein-Barr virus receptor molecule of B lymphocytes.
International journal of cancer. Journal international du cancer 1989;43(5):786-94.
1989: Lawrence S Young; S Finerty; L Brooks; F Scullion; Alan B Rickinson; Andrew J Morgan
Epstein-Barr virus gene expression in malignant lymphomas induced by experimental virus infection of cottontop tamarins.
Journal of virology 1989;63(5):1967-74.
1989: Martin Rowe; Lawrence S Young; K Cadwallader; L Petti; Elliott Kieff; Alan B Rickinson
Distinction between Epstein-Barr virus type A (EBNA 2A) and type B (EBNA 2B) isolates extends to the EBNA 3 family of nuclear proteins.
Journal of virology 1989;63(3):1031-9.
1989: Qing-yun Yao; P Ogan; Martin Rowe; M Wood; Alan B Rickinson
Epstein-Barr virus-infected B cells persist in the circulation of acyclovir-treated virus carriers.
International journal of cancer. Journal international du cancer 1989;43(1):67-71.
1989: Qing-yun Yao; P Ogan; Martin Rowe; M Wood; Alan B Rickinson
The Epstein-Barr virus:host balance in acute infectious mononucleosis patients receiving acyclovir anti-viral therapy.
International journal of cancer. Journal international du cancer 1989;43(1):61-6.
1988: D Ulaeto; L Wallace; A Morgan; B Morein; Alan B Rickinson
In vitro T cell responses to a candidate Epstein-Barr virus vaccine: human CD4+ T cell clones specific for the major envelope glycoprotein gp340.
European journal of immunology 1988;18(11):1689-97.
1988: D Wang; D Liebowitz; Fred Wang; C Gregory; Alan B Rickinson; Richard Larson; T Springer; Elliott Kieff
Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity.
Journal of virology 1988;62(11):4173-84.
1988: R J Murray; D Wang; Lawrence S Young; Fred Wang; Martin Rowe; Elliott Kieff; Alan B Rickinson
Epstein-Barr virus-specific cytotoxic T-cell recognition of transfectants expressing the virus-coded latent membrane protein LMP.
Journal of virology 1988;62(10):3747-55.
1988: Christopher D Gregory; C F Edwards; A Milner; Joëlle Wiels; M Lipinski; Martin Rowe; Thomas Tursz; Alan B Rickinson
Isolation of a normal B cell subset with a Burkitt-like phenotype and transformation in vitro with Epstein-Barr virus.
International journal of cancer. Journal international du cancer 1988;42(2):213-20.
1988: Christopher D Gregory; R J Murray; C F Edwards; Alan B Rickinson
Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance.
The Journal of experimental medicine 1988;167(6):1811-24.
1988: Lawrence S Young; Christopher W Dawson; D Clark; H Rupani; Pierre Busson; Thomas Tursz; A Johnson; Alan B Rickinson
Epstein-Barr virus gene expression in nasopharyngeal carcinoma.
The Journal of general virology 1988;69 ( Pt 5)():1051-65.
1988: R J Murray; Lawrence S Young; Alain Calender; Christopher D Gregory; Martin Rowe; G M Lenoir; Alan B Rickinson
Different patterns of Epstein-Barr virus gene expression and of cytotoxic T-cell recognition in B-cell lines infected with transforming (B95.8) or nontransforming (P3HR1) virus strains.
Journal of virology 1988;62(3):894-901.
1988: John Gordon; M J Millsum; M Finney; J A Cairns; G R Guy; Christopher D Gregory; S D Abbot; Alan B Rickinson; Fred Wang; E Kieff
Altered growth phenotype of a Burkitt's lymphoma line following the introduction and stable expression of the EBNA 2A gene.
Current topics in microbiology and immunology 1988;141():149-56.
1988: Alan B Rickinson; Christopher D Gregory
Burkitt's lymphoma.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1988;82(5):657-9.
1987: G Strang; Alan B Rickinson
In vitro expansion of Epstein-Barr virus-specific HLA-restricted cytotoxic T cells direct from the blood of infectious mononucleosis patients.
Immunology 1987;62(4):647-54.
1987: Lawrence S Young; Qing-yun Yao; C M Rooney; T B Sculley; Denis Moss; H Rupani; G Laux; G W Bornkamm; Alan B Rickinson
New type B isolates of Epstein-Barr virus from Burkitt's lymphoma and from normal individuals in endemic areas.
The Journal of general virology 1987;68 ( Pt 11)():2853-62.
1987: Martin Rowe; D T Rowe; Christopher D Gregory; Lawrence S Young; Paul J Farrell; H Rupani; Alan B Rickinson
Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.
The EMBO journal 1987;6(9):2743-51.
1987: Christopher D Gregory; C Kirchgens; C F Edwards; L S Young; Martin Rowe; A Forster; T H Rabbitts; Alan B Rickinson
Epstein-Barr virus-transformed human precursor B cell lines: altered growth phenotype of lines with germ-line or rearranged but nonexpressed heavy chain genes.
European journal of immunology 1987;17(8):1199-207.
1987: Christopher D Gregory; Thomas Tursz; C F Edwards; C Tetaud; M Talbot; B Caillou; Alan B Rickinson; M Lipinski
Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(1):313-8.
1987: Alan B Rickinson; Christopher D Gregory; Lawrence S Young
Viruses and cancer risks: outgrowth of Epstein-Barr virus-positive Burkitt's lymphoma in the immune host.
Medical oncology and tumor pharmacotherapy 1987;4(3-4):177-86.
1986: C M Rooney; C F Edwards; G M Lenoir; H Rupani; Alan B Rickinson
Differential activation of cytotoxic responses by Burkitt's lymphoma (BL)-cell lines: relationship to the BL-cell surface phenotype.
Cellular immunology 1986;102(1):99-112.
1986: D T Rowe; Martin Rowe; G I Evan; L E Wallace; Paul J Farrell; Alan B Rickinson
Restricted expression of EBV latent genes and T-lymphocyte-detected membrane antigen in Burkitt's lymphoma cells.
The EMBO journal 1986;5(10):2599-607.
1986: C M Rooney; Christopher D Gregory; Martin Rowe; S Finerty; C Edwards; H Rupani; Alan B Rickinson
Endemic Burkitt's lymphoma: phenotypic analysis of tumor biopsy cells and of derived tumor cell lines.
Journal of the National Cancer Institute 1986;77(3):681-7.
1986: T Dambaugh; F Wang; K Hennessy; E Woodland; Alan B Rickinson; Elliott Kieff
Expression of the Epstein-Barr virus nuclear protein 2 in rodent cells.
Journal of virology 1986;59(2):453-62.
1985: Martin Rowe; C M Rooney; Alan B Rickinson; G M Lenoir; H Rupani; Denis Moss; H Stein; M A Epstein
Distinctions between endemic and sporadic forms of Epstein-Barr virus-positive Burkitt's lymphoma.
International journal of cancer. Journal international du cancer 1985;35(4):435-41.