Denis Riendeau

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Giroux André; Boulet Louise; Brideau Christine; Chau Anh; Claveau David; Côté Bernard; Ethier Diane; Frenette Richard; Gagnon Marc; Guay Jocelyne; Guiral Sébastien; Mancini Joseph; Martins Evelyn; Massé Frédéric; Méthot Nathalie; Riendeau Denis; Rubin Joel; Xu Daigen; Yu Hongping; Ducharme Yves; Friesen Richard W
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
Xu Daigen; Rowland Steven E; Clark Patsy; Giroux André; Côté Bernard; Guiral Sébastien; Salem Myriam; Ducharme Yves; Friesen Richard W; Méthot Nathalie; Mancini Joseph; Audoly Laurent; Riendeau Denis
MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
Hétu Pierre-Olivier; Ouellet Marc; Falgueyret Jean-Pierre; Ramachandran Chidambaram; Robichaud Joel; Zamboni Robert; Riendeau Denis
Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E2 synthase-1.

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2009: Giroux André; Boulet Louise; Brideau Christine; Chau Anh; Claveau David; Côté Bernard; Ethier Diane; Frenette Richard; Gagnon Marc; Guay Jocelyne; Guiral Sébastien; Mancini Joseph; Martins Evelyn; Massé Frédéric; Méthot Nathalie; Riendeau Denis; Rubin Joel; Xu Daigen; Yu Hongping; Ducharme Yves; Friesen Richard W
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(20):5837-41.
2008: Xu Daigen; Rowland Steven E; Clark Patsy; Giroux André; Côté Bernard; Guiral Sébastien; Salem Myriam; Ducharme Yves; Friesen Richard W; Méthot Nathalie; Mancini Joseph; Audoly Laurent; Riendeau Denis
MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
The Journal of pharmacology and experimental therapeutics 2008;326(3):754-63.
2008: Hétu Pierre-Olivier; Ouellet Marc; Falgueyret Jean-Pierre; Ramachandran Chidambaram; Robichaud Joel; Zamboni Robert; Riendeau Denis
Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E2 synthase-1.
Archives of biochemistry and biophysics 2008;477(1):155-62.
2008: Méthot Nathalie; Guay Daniel; Rubin Joel; Ethier Diane; Ortega Karen; Wong Simon; Normandin Denis; Beaulieu Christian; Reddy T Jagadeeswar; Riendeau Denis; Percival M David
In vivo inhibition of serine protease processing requires a high fractional inhibition of cathepsin C.
Molecular pharmacology 2008;73(6):1857-65.
2008: Macdonald Dwight; Brideau Christine; Chan Chi Chung; Falgueyret Jean-Pierre; Frenette Richard; Guay Jocelyne; Hutchinson John H; Perrier Hélène; Prasit Peptiboon; Riendeau Denis; Tagari Philip; Thérien Michel; Young Robert N; Girard Yves
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.
Bioorganic & medicinal chemistry letters 2008;18(6):2023-7.
2008: Gauthier Jacques Yves; Chauret Nathalie; Cromlish Wanda; Desmarais Sylvie; Duong Le T; Falgueyret Jean-Pierre; Kimmel Donald B; Lamontagne Sonia; Léger Serge; LeRiche Tammy; Li Chun Sing; Massé Frédéric; McKay Daniel J; Nicoll-Griffith Deborah A; Oballa Renata M; Palmer James T; Percival M David; Riendeau Denis; Robichaud Joel; Rodan Gideon A; Rodan Sevgi B; Seto Carmai; Thérien Michel; Truong Vouy-Linh; Venuti Michael C; Wesolowski Gregg; Young Robert N; Zamboni Robert; Black W Cameron
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
Bioorganic & medicinal chemistry letters 2008;18(3):923-8.
2008: Desmarais Sylvie; Black W Cameron; Oballa Renata; Lamontagne Sonia; Riendeau Denis; Tawa Paul; Duong Le Thi; Pickarski Maureen; Percival M David
Effect of cathepsin k inhibitor basicity on in vivo off-target activities.
Molecular pharmacology 2008;73(1):147-56.
2007: Côté Bernard; Boulet Louise; Brideau Christine; Claveau David; Ethier Diane; Frenette Richard; Gagnon Marc; Giroux André; Guay Jocelyne; Guiral Sébastien; Mancini Joseph; Martins Evelyn; Massé Frédéric; Méthot Nathalie; Riendeau Denis; Rubin Joel; Xu Daigen; Yu Hongping; Ducharme Yves; Friesen Richard W
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(24):6816-20.
2007: Méthot Nathalie; Rubin Joel; Guay Daniel; Beaulieu Christian; Ethier Diane; Reddy T Jagadeeswar; Riendeau Denis; Percival M David
Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.
The Journal of biological chemistry 2007;282(29):20836-46.
2007: Sam Tasia S W; Ngan Man P; Riendeau Denis; Robichaud Annette; Rudd John A
Action of cyclooxygenase inhibitors and a leukotriene biosynthesis inhibitor on cisplatin-induced acute and delayed emesis in the ferret.
Journal of pharmacological sciences 2007;103(2):189-200.
2007: Hétu Pierre-Olivier; Riendeau Denis
Down-regulation of microsomal prostaglandin E2 synthase-1 in adipose tissue by high-fat feeding.
Obesity (Silver Spring, Md.) 2007;15(1):60-8.
2007: Kawka Douglas W; Ouellet Marc; Hétu Pierre-Olivier; Singer Irwin I; Riendeau Denis
Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium.
Biochimica et biophysica acta 2007;1771(1):45-54.
2006: Pulichino Anne-Marie; Rowland Steve; Wu Tom; Clark Patsy; Xu Daigen; Mathieu Marie-Claude; Riendeau Denis; Audoly Laurent P
Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis.
The Journal of pharmacology and experimental therapeutics 2006;319(3):1043-50.
2006: Grimm Erich L; Brideau Christine; Chauret Nathalie; Chan Chi-Chung; Delorme Daniel; Ducharme Yves; Ethier Diane; Falgueyret Jean-Pierre; Friesen Richard W; Guay Jocelyne; Hamel Pierre; Riendeau Denis; Soucy-Breau Chantal; Tagari Philip; Girard Yves
Substituted coumarins as potent 5-lipoxygenase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(9):2528-31.
2006: Li Chun Sing; Deschenes Denis; Desmarais Sylvie; Falgueyret Jean-Pierre; Gauthier Jacques Yves; Kimmel Donald B; Léger Serge; Massé Frédéric; McGrath Mary E; McKay Daniel J; Percival M David; Riendeau Denis; Rodan Sevgi B; Thérien Michel; Truong Vouy-Linh; Wesolowski Gregg; Zamboni Robert; Black W Cameron
Identification of a potent and selective non-basic cathepsin K inhibitor.
Bioorganic & medicinal chemistry letters 2006;16(7):1985-9.
2005: Falgueyret Jean-Pierre; Desmarais Sylvie; Oballa Renata; Black W Cameron; Cromlish Wanda; Khougaz Karine; Lamontagne Sonia; Massé Frederic; Riendeau Denis; Toulmond Sylvie; Percival M David
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.
Journal of medicinal chemistry 2005;48(24):7535-43.
2005: Hétu Pierre-Olivier; Riendeau Denis
Cyclo-oxygenase-2 contributes to constitutive prostanoid production in rat kidney and brain.
The Biochemical journal 2005;391(Pt 3):561-6.
2005: Riendeau Denis; Aspiotis Renee; Ethier Diane; Gareau Yves; Grimm Erich L; Guay Jocelyne; Guiral Sébastien; Juteau Hélène; Mancini Joseph A; Méthot Nathalie; Rubin Joel; Friesen Richard W
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
Bioorganic & medicinal chemistry letters 2005;15(14):3352-5.
2004: Falgueyret Jean-Pierre; Black W Cameron; Cromlish Wanda; Desmarais Sylvie; Lamontagne Sonia; Mellon Christophe; Riendeau Denis; Rodan Sevgi; Tawa Paul; Wesolowski Gregg; Bass Kathryn E; Venkatraman Shankar; Percival M David
An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells.
Analytical biochemistry 2004;335(2):218-27.
2004: Guay Jocelyne; Bateman Kevin; Gordon Robert; Mancini Joseph; Riendeau Denis
Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1.
The Journal of biological chemistry 2004;279(23):24866-72.
2004: Boulet Louise; Ouellet Marc; Bateman Kevin P; Ethier Diane; Percival M David; Riendeau Denis; Mancini Joseph A; Méthot Nathalie
Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile.
The Journal of biological chemistry 2004;279(22):23229-37.
2004: Riendeau Denis; Salem Myriam; Styhler Angela; Ouellet Marc; Mancini Joseph A; Li Chun Sing
Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.
Bioorganic & medicinal chemistry letters 2004;14(5):1201-3.
2003: Claveau David; Sirinyan Mirna; Guay Jocelyne; Gordon Robert; Chan Chi-Chung; Bureau Yves; Riendeau Denis; Mancini Joseph A
Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4738-44.
2003: Black W Cameron; Brideau Christine; Chan Chi Chung; Charleson Stella; Cromlish Wanda; Gordon Robert; Grimm Erich L; Hughes Gregory; Leger Serge; Li Chun Sing; Riendeau Denis; Thérien Michel; Wang Zhaoyin; Xu Li Jing; Prasit Petpiboon
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
Bioorganic & medicinal chemistry letters 2003;13(6):1195-8.
2003: Li Chun Sing; Brideau Christine; Chan Chi Chung; Savoie Chantal; Claveau David; Charleson Stella; Gordon Robert; Greig Gillian; Gauthier Jacques Yves; Lau Cheuk K; Riendeau Denis; Thérien Michel; Wong Elizabeth; Prasit Petpiboon
Pyridazinones as selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(4):597-600.
2003: Ouellet Marc; Pen Ally; Ear Po-Hien; Falgueyret Jean-Pierre; LeRiche Tammy G; Mancini Joseph A; Riendeau Denis; Percival M David
Expression, purification and characterization of recombinant human microsomal PGE2 synthase-1.
Advances in experimental medicine and biology 2003;525():113-6.
2002: Ouellet Marc; Falgueyret Jean-Pierre; Ear Po Hien; Pen Ally; Mancini Joseph A; Riendeau Denis; Percival M David
Purification and characterization of recombinant microsomal prostaglandin E synthase-1.
Protein expression and purification 2002;26(3):489-95.
2002: Leblanc Yves; Roy Patrick; Wang Zhaoyin; Li Chun Sing; Chauret Nathalie; Nicoll-Griffith Deborah A; Silva José M; Aubin Yves; Yergey James A; Chan Chi Chung; Riendeau Denis; Brideau Christine; Gordon Robert; Xu Lijing; Webb Janine; Visco Denise M; Prasit Petpiboon
Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.
Bioorganic & medicinal chemistry letters 2002;12(22):3317-20.
2002: Burleigh Michael E; Babaev Vladimir R; Oates John A; Harris Raymond C; Gautam Shiva; Riendeau Denis; Marnett Lawrence J; Morrow Jason D; Fazio Sergio; Linton MacRae F
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice.
Circulation 2002;105(15):1816-23.
2002: Quraishi Omar; Mancini Joseph A; Riendeau Denis
Inhibition of inducible prostaglandin E(2) synthase by 15-deoxy-Delta(12,14)-prostaglandin J(2) and polyunsaturated fatty acids.
Biochemical pharmacology 2002;63(6):1183-9.
2001: Ouellet M; Riendeau D; Percival M D
A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14583-8.
2001: Guan Y; Zhang Y; Schneider A; Riendeau D; Mancini J A; Davis L; Kömhoff M; Breyer R M; Breyer M D
Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase.
American journal of physiology. Renal physiology 2001;281(6):F1173-7.
2001: Wong E; Huang J Q; Tagari P; Riendeau D
Effects of COX-2 inhibitors on aortic prostacyclin production in cholesterol-fed rabbits.
Atherosclerosis 2001;157(2):393-402.
2001: Chauret N; Yergey J A; Brideau C; Friesen R W; Mancini J; Riendeau D; Silva J; Styhler A; Trimble L A; Nicoll-Griffith D A
In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).
Bioorganic & medicinal chemistry letters 2001;11(8):1059-62.
2001: Claveau D; Riendeau D
Mutations of the C-terminal end of cathepsin K affect proenzyme secretion and intracellular maturation.
Biochemical and biophysical research communications 2001;281(2):551-7.
2001: Riendeau D; Percival M D; Brideau C; Charleson S; Dubé D; Ethier D; Falgueyret J P; Friesen R W; Gordon R; Greig G; Guay J; Mancini J; Ouellet M; Wong E; Xu L; Boyce S; Visco D; Girard Y; Prasit P; Zamboni R; Rodger I W; Gresser M; Ford-Hutchinson A W; Young R N; Chan C C
Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.
The Journal of pharmacology and experimental therapeutics 2001;296(2):558-66.
2001: Mancini J A; Blood K; Guay J; Gordon R; Claveau D; Chan C C; Riendeau D
Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis.
The Journal of biological chemistry 2001;276(6):4469-75.
2001: Falgueyret J P; Oballa R M; Okamoto O; Wesolowski G; Aubin Y; Rydzewski R M; Prasit P; Riendeau D; Rodan S B; Percival M D
Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.
Journal of medicinal chemistry 2001;44(1):94-104.
2000: Nicoll-Griffith D A; Yergey J A; Trimble L A; Silva J M; Li C; Chauret N; Gauthier J Y; Grimm E; Léger S; Roy P; Thérien M; Wang Z; Prasit P; Zamboni R; Young R N; Brideau C; Chan C C; Mancini J; Riendeau D
Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).
Bioorganic & medicinal chemistry letters 2000;10(23):2683-6.
2000: Claveau D; Riendeau D; Mancini J A
Expression, maturation, and rhodamine-based fluorescence assay of human cathepsin K expressed in CHO cells.
Biochemical pharmacology 2000;60(6):759-69.
2000: Falgueyret J; Riendeau D
LTA(4)-derived 5-oxo-eicosatetraenoic acid: pH-dependent formation and interaction with the LTB(4) receptor of human polymorphonuclear leukocytes.
Biochimica et biophysica acta 2000;1484(1):51-8.
1999: Lau C K; Brideau C; Chan C C; Charleson S; Cromlish W A; Ethier D; Gauthier J Y; Gordon R; Guay J; Kargman S; Li C S; Prasit P; Riendeau D; Thérien M; Visco D M; Xu L
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(22):3187-92.
1999: Li C S; Black W C; Brideau C; Chan C C; Charleson S; Cromlish W A; Claveau D; Gauthier J Y; Gordon R; Greig G; Grimm E; Guay J; Lau C K; Riendeau D; Thérien M; Visco D M; Wong E; Xu L; Prasit P
A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(22):3181-6.
1999: Frenette R; Hutchinson J H; Léger S; Thérien M; Brideau C; Chan C C; Charleson S; Ethier D; Guay J; Jones T R; McAuliffe M; Piechuta H; Riendeau D; Tagari P; Girard Y
Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(16):2391-6.
1999: Leblanc Y; Roy P; Boyce S; Brideau C; Chan C C; Charleson S; Gordon R; Grimm E; Guay J; Léger S; Li C S; Riendeau D; Visco D; Wang Z; Webb J; Xu L J; Prasit P
SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.
Bioorganic & medicinal chemistry letters 1999;9(15):2207-12.
1999: Guay J; Riendeau D; Mancini J A
Cloning and expression of rhesus monkey cathepsin K.
Bone 1999;25(2):205-9.
1999: Prasit P; Wang Z; Brideau C; Chan C C; Charleson S; Cromlish W; Ethier D; Evans J F; Ford-Hutchinson A W; Gauthier J Y; Gordon R; Guay J; Gresser M; Kargman S; Kennedy B; Leblanc Y; Léger S; Mancini J; O'Neill G P; Ouellet M; Percival M D; Perrier H; Riendeau D; Rodger I; Zamboni R
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
Bioorganic & medicinal chemistry letters 1999;9(13):1773-8.
1999: Dubé D; Brideau C; Deschênes D; Fortin R; Friesen R W; Gordon R; Girard Y; Riendeau D; Savoie C; Chan C C
2-heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(12):1715-20.
1999: Black W C; Brideau C; Chan C C; Charleson S; Chauret N; Claveau D; Ethier D; Gordon R; Greig G; Guay J; Hughes G; Jolicoeur P; Leblanc Y; Nicoll-Griffith D; Ouimet N; Riendeau D; Visco D; Wang Z; Xu L; Prasit P
2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.
Journal of medicinal chemistry 1999;42(7):1274-81.
1999: Nicoll-Griffith D A; Falgueyret J P; Silva J M; Morin P E; Trimble L; Chan C C; Clas S; Leger S; Wang Z; Yergey J A; Riendeau D
Oxidative bioactivation of the lactol prodrug of a lactone cyclooxygenase-2 inhibitor.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(3):403-9.
1999: Denis D; Riendeau D
Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes.
European journal of pharmacology 1999;367(2-3):343-50.
1999: Ouimet N; Chan C C; Charleson S; Claveau D; Gordon R; Guay D; Li C S; Ouellet M; Percival D M; Riendeau D; Wong E; Zamboni R; Prasit P
Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class.
Bioorganic & medicinal chemistry letters 1999;9(2):151-6.
1998: Mancini J A; Waterman H; Riendeau D
Cellular oxygenation of 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid by 5-lipoxygenase is stimulated by 5-lipoxygenase-activating protein.
The Journal of biological chemistry 1998;273(49):32842-7.
1998: Friesen R W; Brideau C; Chan C C; Charleson S; Deschênes D; Dubé D; Ethier D; Fortin R; Gauthier J Y; Girard Y; Gordon R; Greig G M; Riendeau D; Savoie C; Wang Z; Wong E; Visco D; Xu L J; Young R N
2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(19):2777-82.
1998: Dubé D; Blouin M; Brideau C; Chan C C; Desmarais S; Ethier D; Falgueyret J P; Friesen R W; Girard M; Girard Y; Guay J; Riendeau D; Tagari P; Young R N
Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.
Bioorganic & medicinal chemistry letters 1998;8(10):1255-60.
1997: Riendeau D; Charleson S; Cromlish W; Mancini J A; Wong E; Guay J
Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays.
Canadian journal of physiology and pharmacology 1997;75(9):1088-95.
1997: Jakobsson P J; Mancini J A; Riendeau D; Ford-Hutchinson A W
Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.
The Journal of biological chemistry 1997;272(36):22934-9.
1997: Hamel P; Riendeau D; Brideau C; Chan C C; Desmarais S; Delorme D; Dubé D; Ducharme Y; Ethier D; Grimm E; Falgueyret J P; Guay J; Jones T R; Kwong E; McAuliffe M; McFarlane C S; Piechuta H; Roumi M; Tagari P; Young R N; Girard Y
Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.
Journal of medicinal chemistry 1997;40(18):2866-75.
1997: Riendeau D; Percival M D; Boyce S; Brideau C; Charleson S; Cromlish W; Ethier D; Evans J; Falgueyret J P; Ford-Hutchinson A W; Gordon R; Greig G; Gresser M; Guay J; Kargman S; Léger S; Mancini J A; O'Neill G; Ouellet M; Rodger I W; Thérien M; Wang Z; Webb J K; Wong E; Chan C C
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
British journal of pharmacology 1997;121(1):105-17.
1997: Wong E; Bayly C; Waterman H L; Riendeau D; Mancini J A
Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation.
The Journal of biological chemistry 1997;272(14):9280-6.
1997: Wong E; DeLuca C; Boily C; Charleson S; Cromlish W; Denis D; Kargman S; Kennedy B P; Ouellet M; Skorey K; O'Neill G P; Vickers P J; Riendeau D
Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(2):51-9.
1997: Mancini J A; Vickers P J; O'Neill G P; Boily C; Falgueyret J P; Riendeau D
Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs.
Molecular pharmacology 1997;51(1):52-60.
1997: Riendeau D; Falgueyret J P; Gravel J; Trimble L; Yergey J
Non-enzymatic rearrangement of leukotriene A4 to 5-keto-(7E,9E,11Z,14Z)-eicosatetraenoic acid in aqueous media.
Advances in experimental medicine and biology 1997;400A():71-6.
1996: Kargman S; Wong E; Greig G M; Falgueyret J P; Cromlish W; Ethier D; Yergey J A; Riendeau D; Evans J F; Kennedy B; Tagari P; Francis D A; O'Neill G P
Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells.
Biochemical pharmacology 1996;52(7):1113-25.
1996: Delorme D; Ducharme Y; Brideau C; Chan C C; Chauret N; Desmarais S; Dubé D; Falgueyret J P; Fortin R; Guay J; Hamel P; Jones T R; Lépine C; Li C; McAuliffe M; McFarlane C S; Nicoll-Griffith D A; Riendeau D; Yergey J A; Girard Y
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.
Journal of medicinal chemistry 1996;39(20):3951-70.
1996: Kargman S; Charleson S; Cartwright M; Frank J; Riendeau D; Mancini J; Evans J; O'Neill G
Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts.
Gastroenterology 1996;111(2):445-54.
1996: De Carolis E; Denis D; Riendeau D
Oxidative inactivation of human 5-lipoxygenase in phosphatidylcholine vesicles.
European journal of biochemistry / FEBS 1996;235(1-2):416-23.
1995: Mancini J A; Riendeau D; Falgueyret J P; Vickers P J; O'Neill G P
Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety.
The Journal of biological chemistry 1995;270(49):29372-7.
1995: Falgueyret J P; Denis D; Macdonald D; Hutchinson J H; Riendeau D
Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization.
Biochemistry 1995;34(41):13603-11.
1994: Desmarais S R; Riendeau D; Gresser M J
Inhibition of soybean lipoxygenase-1 by a diaryl-N-hydroxyurea by reduction of the ferric enzyme.
Biochemistry 1994;33(45):13391-400.
1994: Riendeau D; Guay J; Weech P K; Laliberté F; Yergey J; Li C; Desmarais S; Perrier H; Liu S; Nicoll-Griffith D
Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.
The Journal of biological chemistry 1994;269(22):15619-24.
1994: Hutchinson J H; Riendeau D; Brideau C; Chan C; Falgueyret J P; Guay J; Jones T R; Lépine C; Macdonald D; McFarlane C S
Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.
Journal of medicinal chemistry 1994;37(8):1153-64.
1994: Ducharme Y; Brideau C; Dubé D; Chan C C; Falgueyret J P; Gillard J W; Guay J; Hutchinson J H; McFarlane C S; Riendeau D
Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.
Journal of medicinal chemistry 1994;37(4):512-8.
1993: Gravel J; Falgueyret J P; Yergey J; Trimble L; Riendeau D
Identification of 5-keto-(7E,9E,11Z,14Z)-eicosatetraenoic acid as a novel nonenzymatic rearrangement product of leukotriene A4.
Archives of biochemistry and biophysics 1993;306(2):469-75.
1993: Hutchinson J H; Riendeau D; Brideau C; Chan C; Delorme D; Denis D; Falgueyret J P; Fortin R; Guay J; Hamel P
Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.
Journal of medicinal chemistry 1993;36(19):2771-87.
1993: Chasteen N D; Grady J K; Skorey K I; Neden K J; Riendeau D; Percival M D
Characterization of the non-heme iron center of human 5-lipoxygenase by electron paramagnetic resonance, fluorescence, and ultraviolet-visible spectroscopy: redox cycling between ferrous and ferric states.
Biochemistry 1993;32(37):9763-71.
1993: Riendeau D; Falgueyret J P; Meisner D; Sherman M M; Laliberté F; Street I P
Interfacial catalysis and production of a high ratio of leukotriene A4 to 5-HPETE by 5-lipoxygenase in a coupled assay with phospholipase A2.
Journal of lipid mediators 1993;6(1-3):23-30.
1993: Falgueyret J P; Hutchinson J H; Riendeau D
Criteria for the identification of non-redox inhibitors of 5-lipoxygenase.
Biochemical pharmacology 1993;45(4):978-81.
1992: Percival M D; Denis D; Riendeau D; Gresser M J
Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase. Inactivation by H2O2 and inhibition by metal ions.
European journal of biochemistry / FEBS 1992;210(1):109-17.
1992: Lau C K; Bélanger P C; Dufresne C; Scheigetz J; Therien M; Fitzsimmons B; Young R N; Ford-Hutchinson A W; Riendeau D; Denis D
Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.
Journal of medicinal chemistry 1992;35(7):1299-318.
1992: Falgueyret J P; Desmarais S; Roy P J; Riendeau D
N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea, a general reducing agent for 5-, 12-, and 15-lipoxygenases and a substrate for their pseudoperoxidase activities.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(3-4):228-36.
1991: Nguyen T; Falgueyret J P; Abramovitz M; Riendeau D
Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase.
The Journal of biological chemistry 1991;266(32):22057-62.
1991: Rouzer C A; Riendeau D; Falgueyret J P; Lau C K; Gresser M J
Inhibition of human leukocyte 5-lipoxygenase by a 4-hydroxybenzofuran, L-656,224. Evidence for enzyme reduction and inhibitor degradation.
Biochemical pharmacology 1991;41(9):1365-73.
1991: Denis D; Falgueyret J P; Riendeau D; Abramovitz M
Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors.
The Journal of biological chemistry 1991;266(8):5072-9.
1991: Riendeau D; Falgueyret J P; Guay J; Ueda N; Yamamoto S
Pseudoperoxidase activity of 5-lipoxygenase stimulated by potent benzofuranol and N-hydroxyurea inhibitors of the lipoxygenase reaction.
The Biochemical journal 1991;274 ( Pt 1)():287-92.
1991: Riendeau D; Guay J; Foster A; Wolfe S; Chan C C
Inhibition of leukotriene B4 biosynthesis by disulfiram and A-64077 during carrageenan-induced pleurisy in the rat.
General pharmacology 1991;22(2):371-4.
1990: Falgueyret J P; Leblanc Y; Riendeau D
Stereoselective carbonyl reductases from rat skin and leukocyte microsomes converting 12-ketoeicosatetraenoic acid to 12(S)-HETE.
FEBS letters 1990;262(2):197-200.
1989: Riendeau D; Denis D; Choo L Y; Nathaniel D J
Stimulation of 5-lipoxygenase activity under conditions which promote lipid peroxidation.
The Biochemical journal 1989;263(2):565-72.
1989: Denis D; Choo L Y; Riendeau D
Activation of 5-lipoxygenase by guanosine 5'-O-(3-thiotriphosphate) and other nucleoside phosphorothioates: redox properties of thionucleotide analogs.
Archives of biochemistry and biophysics 1989;273(2):592-6.
1989: Riendeau D; Falgueyret J P; Nathaniel D J; Rokach J; Ueda N; Yamamoto S
Sensitivity of immunoaffinity-purified porcine 5-lipoxygenase to inhibitors and activating lipid hydroperoxides.
Biochemical pharmacology 1989;38(14):2313-21.
1988: Falgueyret J P; Leblanc Y; Rokach J; Riendeau D
NAD(P)H-dependent reduction of 12-ketoeicosatetraenoic acid to 12(R)- and 12(S)-hydroxyeicosatetraenoic acid by rat liver microsomes.
Biochemical and biophysical research communications 1988;156(3):1083-9.
1987: Choo L Y; Riendeau D
Disulfiram is a potent inhibitor of rat 5-lipoxygenase activity.
Canadian journal of physiology and pharmacology 1987;65(12):2503-6.
1986: Riendeau D; Leblanc Y
Modulation of rat polymorphonuclear leukocyte 5-lipoxygenase activity by 5-HPETE and NADH-dependent flavin inhibition.
Biochemical and biophysical research communications 1986;141(2):534-40.

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