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Jean-François Riou

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Céline Douarre; Dennis Gomez; Patrick Mailliet; Xénia Mergui; Assitan Sidibe; Chantal Trentesaux; Patrizia Alberti; Jean-François Riou
DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase.
Assitan Sidibe; Marie-Paule Teulade-Fichou; Chantal Trentesaux; Dennis Gomez; Florian Hamon; Eric Largy; Jean-François Riou
Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells.
Sonja M Hampel; Assitan Sidibe; Mekala Gunaratnam; Jean-François Riou; Stephen Neidle
Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.

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2013: Céline Douarre; Dennis Gomez; Patrick Mailliet; Xénia Mergui; Assitan Sidibe; Chantal Trentesaux; Patrizia Alberti; Jean-François Riou
DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase.
Nucleic acids research 2013;41(6):3588-99.
2012: Assitan Sidibe; Marie-Paule Teulade-Fichou; Chantal Trentesaux; Dennis Gomez; Florian Hamon; Eric Largy; Jean-François Riou
Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells.
Biochimie 2012;94(12):2559-68.
2010: Sonja M Hampel; Assitan Sidibe; Mekala Gunaratnam; Jean-François Riou; Stephen Neidle
Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.
Bioorganic & medicinal chemistry letters 2010;20(22):6459-63.
2010: Chantal Trentesaux; Jean-François Riou
[Senescence and cellular immortality].
Bulletin du cancer 2010;97(11):1275-83.
2010: Marie Laronze-Cochard; Fabien Cochard; Etienne Daras; Amélie Lansiaux; Bertrand BRASSART; Enguerran Vanquelef; Elise Prost; Jean-Marc Nuzillard; Brigitte Baldeyrou; Jean-François Goosens; Olivier Lozach; Laurent Meijer; Jean-François Riou; Eric Henon; Janos Sapi
Synthesis and biological evaluation of new penta- and heptacyclic indolo- and quinolinocarbazole ring systems obtained via Pd(0) catalysed reductive N-heteroannulation.
Organic & biomolecular chemistry 2010;8(20):4625-36.
2009: Nausica Arnoult; Carole Saintome; Isabelle Ourliac-Garnier; Jean-François Riou; Arturo Londoño-Vallejo
Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.
Genes & development 2009;23(24):2915-24.
2009: Aaron Mendez-Bermudez; Mark Hills; Hilda A Pickett; Anh Tuân Phan; Jean-Louis Mergny; Jean-François Riou; Nicola J Royle
Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline.
Nucleic acids research 2009;37(18):6225-38.
2009: Marie Laronze-Cochard; Young-Min Kim; Bertrand BRASSART; Jean-François Riou; Jean-Yves Laronze; Janos Sapi
Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.
European journal of medicinal chemistry 2009;44(10):3880-8.
2009: Nassima Temime-Smaali; Lionel Guittat; Assitan Sidibe; Kazuo Shin-ya; Chantal Trentesaux; Jean-François Riou
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells.
PloS one 2009;4(9):e6919.
2008: Nassima Temime-Smaali; Lionel Guittat; Thomas Wenner; Emilie Bayart; Céline Douarre; Dennis Gomez; Marie-Josèphe Giraud-Panis; Arturo Londono-Vallejo; Eric Gilson; Mounira Amor-Guéret; Jean-François Riou
Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.
The EMBO journal 2008;27(10):1513-24.
2008: Anne DE CIAN; Julien Gros; Aurore Guédin; Meriem Haddi; Sébastien Lyonnais; Lionel Guittat; Jean-François Riou; Chantal Trentesaux; Barbara Saccà; Laurent Lacroix; Patrizia Alberti; Jean-Louis Mergny
DNA and RNA quadruplex ligands.
Nucleic acids symposium series (2004) 2008;(52):7-8.
2008: Gabriel D Mazzucchelli; Valérie Gabelica; Nicolas Smargiasso; Maximilien Fléron; Wilson Ashimwe; Frédéric Rosu; Marie-Claire De Pauw-Gillet; Jean-François Riou; Edwin De Pauw
Proteome alteration induced by hTERT transfection of human fibroblast cells.
Proteome science 2008;6():12.
2008: Anne DE CIAN; Laurent Lacroix; Céline Douarre; Nassima Temime-Smaali; Chantal Trentesaux; Jean-François Riou; Jean-Louis Mergny
Targeting telomeres and telomerase.
Biochimie 2008;90(1):131-55.
2007: Mekala Gunaratnam; Olga Greciano; Cristina Martins; Anthony P Reszka; Christoph Schultes; Hamid Morjani; Jean-François Riou; Stephen Neidle
Mechanism of acridine-based telomerase inhibition and telomere shortening.
Biochemical pharmacology 2007;74(5):679-89.
2007: Bertrand BRASSART; Dennis Gomez; Anne DE CIAN; Rajaa Paterski; Alain Montagnac; Khuong-Huu Qui; Nassima Temime-Smaali; Chantal Trentesaux; Jean-Louis Mergny; Françoise Gueritte; Jean-François Riou
A new steroid derivative stabilizes g-quadruplexes and induces telomere uncapping in human tumor cells.
Molecular pharmacology 2007;72(3):631-40.
2006: Dennis Gomez; Thomas Wenner; Bertrand BRASSART; Céline Douarre; Marie-Françoise O'donohue; Victoria El-Khoury; Kazuo Shin-ya; Hamid Morjani; Chantal Trentesaux; Jean-François Riou
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.
The Journal of biological chemistry 2006;281(50):38721-9.
2006: Dennis Gomez; Marie-Françoise O'donohue; Thomas Wenner; Céline Douarre; Jérome Macadré; Pascale Koebel; Marie-Josèphe Giraud-Panis; Hervé Kaplan; Alain Kolkes; Kazuo Shin-ya; Jean-François Riou
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells.
Cancer research 2006;66(14):6908-12.
2006: Jean-François Riou; Hamid Morjani; Chantal Trentesaux
[Telomeres and telomerase, new targets for anticancer chemotherapy].
Annales pharmaceutiques françaises 2006;64(2):97-105.
2005: Claude Dupont; Eric Courot; Reynald Gillet; Catherine Caron; Monique Zeches-Hanrot; Jean-François Riou; Chantal Trentesaux
The benzophenanthridine alkaloid fagaronine induces erythroleukemic cell differentiation by gene activation.
Planta medica 2005;71(6):489-94.
2005: Gaëlle Pennarun; Christine Granotier; Laurent Gauthier; Dennis Gomez; Françoise Hoffschir; Eliane Mandine; Jean-François Riou; Jean-Louis Mergny; Patrick Mailliet; François D Boussin
Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands.
Oncogene 2005;24(18):2917-28.
2005: Anne DE CIAN; Lionel Guittat; Kazuo Shin-ya; Jean-François Riou; Jean-Louis Mergny
Affinity and selectivity of G4 ligands measured by FRET.
Nucleic acids symposium series (2004) 2005;(49):235-6.
2005: Christine Granotier; Gaëlle Pennarun; Lydia Riou; Françoise Hoffschir; Laurent Gauthier; Anne DE CIAN; Dennis Gomez; Eliane Mandine; Jean-François Riou; Jean-Louis Mergny; Patrick Mailliet; Bernard Dutrillaux; François D Boussin
Preferential binding of a G-quadruplex ligand to human chromosome ends.
Nucleic acids research 2005;33(13):4182-90.
2005: Céline Douarre; Dennis Gomez; Hamid Morjani; Jean-Marie Zahm; Marie-Françoise O'donohue; Lahcen Eddabra; Patrick Mailliet; Jean-François Riou; Chantal Trentesaux
Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence.
Nucleic acids research 2005;33(7):2192-203.
2005: Jean-François Riou; Dennis Gomez; Jean-Louis Mergny; Lionel Guittat; Rajaa Paterski; Benoît Chénais; Hamid Morjani; Chantal Trentesaux
[Regulation of telomeres length: making the telomeres accessible?].
Bulletin du cancer 2005;92(1):13-22.
2004: Thibault Lemarteleur; Dennis Gomez; Rajaa Paterski; Eliane Mandine; Patrick Mailliet; Jean-François Riou
Stabilization of the c-myc gene promoter quadruplex by specific ligands' inhibitors of telomerase.
Biochemical and biophysical research communications 2004;323(3):802-8.
2004: Dennis Gomez; Rajaa Paterski; Thibault Lemarteleur; Kazuo Shin-ya; Jean-Louis Mergny; Jean-François Riou
Interaction of telomestatin with the telomeric single-strand overhang.
The Journal of biological chemistry 2004;279(40):41487-94.
2004: Lionel Guittat; Patrizia Alberti; Dennis Gomez; Anne DE CIAN; Gaëlle Pennarun; Thibault Lemarteleur; Chafke Belmokhtar; Rajaa Paterski; Hamid Morjani; Chantal Trentesaux; Eliane Mandine; François Boussin; Patrick Mailliet; Laurent Lacroix; Jean-François Riou; Jean-Louis Mergny
Targeting human telomerase for cancer therapeutics.
Cytotechnology 2004;45(1-2):75-90.
2004: Dennis Gomez; Thibault Lemarteleur; Laurent Lacroix; Patrick Mailliet; Jean-Louis Mergny; Jean-François Riou
Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.
Nucleic acids research 2004;32(1):371-9.
2003: Dennis Gomez; Nassera Aouali; Arturo Londoño-Vallejo; Laurent Lacroix; Frédérique Mégnin-Chanet; Thibault Lemarteleur; Céline Douarre; Kazuo Shin-ya; Patrick Mailliet; Chantal Trentesaux; Hamid Morjani; Jean-Louis Mergny; Jean-François Riou
Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration.
The Journal of biological chemistry 2003;278(50):50554-62.
2003: Dennis Gomez; Nassera Aouali; Alexandra Renaud; Céline Douarre; Kazuo Shin-ya; Jamal Tazi; Sophie Martinez; Chantal Trentesaux; Hamid Morjani; Jean-François Riou
Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase.
Cancer research 2003;63(19):6149-53.
2003: Frédéric Rosu; Edwin De Pauw; Lionel Guittat; Patrizia Alberti; Laurent Lacroix; Patrick Mailliet; Jean-François Riou; Jean-Louis Mergny
Selective interaction of ethidium derivatives with quadruplexes: an equilibrium dialysis and electrospray ionization mass spectrometry analysis.
Biochemistry 2003;42(35):10361-71.
2003: Gilles Breuzard; Jean-Marc Millot; Jean-François Riou; Michel Manfait
Selective interactions of ethidiums with G-quadruplex DNA revealed by surface-enhanced Raman scattering.
Analytical chemistry 2003;75(16):4305-11.
2003: Lionel Guittat; Patrizia Alberti; Frédéric Rosu; Sabine van Miert; Emilie Thetiot; Luc Pieters; Valérie Gabelica; Edwin De Pauw; Alexandre Ottaviani; Jean-François Riou; Jean-Louis Mergny
Interactions of cryptolepine and neocryptolepine with unusual DNA structures.
Biochimie 2003;85(5):535-47.
2003: Jean-François Riou; Dennis Gomez; Thibault Lemarteleur; Chantal Trentesaux
[G-quadruplex DNA: myth or reality?].
Bulletin du cancer 2003;90(4):305-13.
2002: Dennis Gomez; Jean-Louis Mergny; Jean-François Riou
Detection of telomerase inhibitors based on g-quadruplex ligands by a modified telomeric repeat amplification protocol assay.
Cancer research 2002;62(12):3365-8.
2002: Jean-François Riou; Lionel Guittat; Patrick Mailliet; Abdelazize Laoui; E Renou; O Petitgenet; Frédérique Mégnin-Chanet; Claude Hélène; Jean-Louis Mergny
Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2672-7.
2002: Jean-Louis Mergny; Jean-François Riou; Patrick Mailliet; Marie-Paule Teulade-Fichou; Eric Gilson
Natural and pharmacological regulation of telomerase.
Nucleic acids research 2002;30(4):839-65.
2001: Patrizia Alberti; J Ren; Marie-Paule Teulade-Fichou; Lionel Guittat; Jean-François Riou; Jonathan B Chaires; Claude Hélène; Jean-Pierre Vigneron; Jean-Marie Lehn; Jean-Louis Mergny
Interaction of an acridine dimer with DNA quadruplex structures.
Journal of biomolecular structure & dynamics 2001;19(3):505-13.
2001: B Pilch; eric Allemand; M Facompré; Christian Bailly; Jean-François Riou; Johann Soret; Jamal Tazi
Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.
Cancer research 2001;61(18):6876-84.
2001: Jean-Louis Mergny; Laurent Lacroix; Marie-Paule Teulade-Fichou; Candide Hounsou; Lionel Guittat; M Hoarau; Paola B Arimondo; Jean-Pierre Vigneron; Jean-Marie Lehn; Jean-François Riou; Thérèse Garestier; Claude Hélène
Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3062-7.
2001: F Koeppel; Jean-François Riou; Abdelazize Laoui; Patrick Mailliet; Paola B Arimondo; D Labit; O Petitgenet; Claude Hélène; Jean-Louis Mergny
Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes.
Nucleic acids research 2001;29(5):1087-96.
2000: Paola B Arimondo; Jean-François Riou; Jean-Louis Mergny; Jamal Tazi; Jian-Sheng Sun; Thérèse Garestier; Claude Hélène
Interaction of human DNA topoisomerase I with G-quartet structures.
Nucleic acids research 2000;28(24):4832-8.
2000: E Giraud; C Luttmann; F Lavelle; Jean-François Riou; Patrick Mailliet; Abdelazize Laoui
Multivariate data analysis using D-optimal designs, partial least squares, and response surface modeling: A directional approach for the analysis of farnesyltransferase inhibitors.
Journal of medicinal chemistry 2000;43(9):1807-16.
2000: F Lavelle; Jean-François Riou; Abdelazize Laoui; Patrick Mailliet
Telomerase: a therapeutic target for the third millennium?
Critical reviews in oncology/hematology 2000;34(2):111-26.
2000: Leonard Wu; Sally L Davies; Phillip S North; H Goulaouic; Jean-François Riou; Helen Turley; K C Gatter; Ian D Hickson
The Bloom's syndrome gene product interacts with topoisomerase III.
The Journal of biological chemistry 2000;275(13):9636-44.
1999: Jean-Louis Mergny; Patrick Mailliet; F Lavelle; Jean-François Riou; Abdelazize Laoui; Claude Hélène
The development of telomerase inhibitors: the G-quartet approach.
Anti-cancer drug design 1999;14(4):327-39.
1999: H Goulaouic; T Roulon; O Flamand; L Grondard; F Lavelle; Jean-François Riou
Purification and characterization of human DNA topoisomerase IIIalpha.
Nucleic acids research 1999;27(12):2443-50.
1999: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; D Sevère; Jean-François Riou; Jean-François Goossens; Jean-Pierre Hénichart; Christian Bailly; E Labourier; J Tazzi; Doriano Fabbro; T Meyer; AM Aubertin
Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
Journal of medicinal chemistry 1999;42(10):1816-22.
1999: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; Christian Bailly; D Sevère; Jean-François Riou; Doriano Fabbro; T Meyer; AM Aubertin
Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
Journal of medicinal chemistry 1999;42(4):584-92.
1999: Christian Bailly; Xiaogang Qu; Fabrice Anizon; Michelle Prudhomme; Jean-François Riou; Jonathan B Chaires
Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue.
Molecular pharmacology 1999;55(2):377-85.
1999: E Labourier; Jean-François Riou; Michelle Prudhomme; C Carrasco; Christian Bailly; Jamal Tazi
Poisoning of topoisomerase I by an antitumor indolocarbazole drug: stabilization of topoisomerase I-DNA covalent complexes and specific inhibition of the protein kinase activity.
Cancer research 1999;59(1):52-5.
1998: Fabrice Anizon; Pascale Moreau; Martine Sancelme; Aline Voldoire; Michelle Prudhomme; M Ollier; D Sevère; Jean-François Riou; Christian Bailly; Doriano Fabbro; T Meyer; AM Aubertin
Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin.
Bioorganic & medicinal chemistry 1998;6(9):1597-604.
1998: I Chourpa; Jean-François Riou; Jean-Marc Millot; Y Pommier; Michel Manfait
Modulation in kinetics of lactone ring hydrolysis of camptothecins upon interaction with topoisomerase I cleavage sites on DNA.
Biochemistry 1998;37(20):7284-91.
1998: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; Christian Bailly; C Carrasco; M Ollier; D Sevère; Jean-François Riou; Doriano Fabbro; T Meyer; AM Aubertin
Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Journal of medicinal chemistry 1998;41(10):1631-40.
1998: Igor Nabiev; Fabrice Fleury; Irina A Kudelina; Y Pommier; F Charton; Jean-François Riou; Alain J.P. Alix; Michel Manfait
Spectroscopic and biochemical characterisation of self-aggregates formed by antitumor drugs of the camptothecin family: their possible role in the unique mode of drug action.
Biochemical pharmacology 1998;55(8):1163-74.
1998: I Chourpa; Jean-Marc Millot; Ganesh Dhruvananda Sockalingum; Jean-François Riou; Michel Manfait
Kinetics of lactone hydrolysis in antitumor drugs of camptothecin series as studied by fluorescence spectroscopy.
Biochimica et biophysica acta 1998;1379(3):353-66.
1997: Fabrice Anizon; L Belin; Pascale Moreau; Martine Sancelme; Aline Voldoire; Michelle Prudhomme; M Ollier; D Sevère; Jean-François Riou; Christian Bailly; Doriano Fabbro; T Meyer
Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
Journal of medicinal chemistry 1997;40(21):3456-65.
1997: E R Pereira; Michelle Prudhomme; Martine Sancelme; M Ollier; D Severe; Jean-François Riou; Huguette Crevel; Jean-Pierre Savineau; Doriano Fabbro; T Meyer
Synthesis and biological evaluation of monoindolyl and indolocarbazolyl oxazolones and imidazolones.
Chemical & pharmaceutical bulletin 1997;45(4):733-6.
1997: I Chourpa; Abdelilah Beljebbar; Ganesh Dhruvananda Sockalingum; Jean-François Riou; Michel Manfait
Structure-activity relation in camptothecin antitumor drugs: why a detailed molecular characterisation of their lactone and carboxylate forms by Raman and SERS spectroscopies?
Biochimica et biophysica acta 1997;1334(2-3):349-60.
1996: I Chourpa; Hamid Morjani; Jean-François Riou; Michel Manfait
Intracellular molecular interactions of antitumor drug amsacrine (m-AMSA) as revealed by surface-enhanced Raman spectroscopy.
FEBS letters 1996;397(1):61-4.
1996: Alexei V Feofanov; A V Baranov; Fabrice Fleury; Jean-François Riou; Igor Nabiev; Michel Manfait
DNA topoisomerase I changes the mode of interaction between camptothecin drugs and DNA as probed by UV-resonance Raman spectroscopy.
FEBS letters 1996;396(2-3):289-92.
1996: E R Pereira; L Belin; Martine Sancelme; M Prudhomme; M Ollier; Maryse Rapp; D Sevère; Jean-François Riou; Doriano Fabbro; T Meyer
Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
Journal of medicinal chemistry 1996;39(22):4471-7.
1996: C Gobert; L Bracco; F Rossi; Magali Olivier; Jamal Tazi; F Lavelle; Annette K Larsen; Jean-François Riou
Modulation of DNA topoisomerase I activity by p53.
Biochemistry 1996;35(18):5778-86.
1996: F Rossi; E Labourier; T Forné; G Divita; Jean Derancourt; Jean-François Riou; E Antoine; G Cathala; C Brunel; Jamal Tazi
Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I.
Nature 1996;381(6577):80-2.
1996: F Lavelle; MC Bissery; S André; F Roquet; Jean-François Riou
Preclinical evaluation of CPT-11 and its active metabolite SN-38.
Seminars in oncology 1996;23(1 Suppl 3):11-20.
1995: Jean-François Riou; L Grondard; A Naudin; C Bailly
Effects of two distamycin-ellipticine hybrid molecules on topoisomerase I and II mediated DNA cleavage: relation to cytotoxicity.
Biochemical pharmacology 1995;50(3):424-8.
1995: Chi Hung Nguyen; E Fan; Jean-François Riou; MC Bissery; P Vrignaud; F Lavelle; Emile Bisagni
Synthesis and biological evaluation of amino-substituted benzo[f]pyrido[4,3-b] and pyrido[3,4-b]quinoxalines: a new class of antineoplastic agents.
Anti-cancer drug design 1995;10(4):277-97.
1995: F Lavelle; MC Bissery; C Combeau; Jean-François Riou; P Vrignaud; S André
Preclinical evaluation of docetaxel (Taxotere).
Seminars in oncology 1995;22(2 Suppl 4):3-16.
1994: Iwao Ojima; O Duclos; M Zucco; MC Bissery; C Combeau; P Vrignaud; Jean-François Riou; F Lavelle
Synthesis and structure-activity relationships of new antitumor taxoids. Effects of cyclohexyl substitution at the C-3' and/or C-2 of taxotere (docetaxel).
Journal of medicinal chemistry 1994;37(16):2602-8.
1994: Igor Nabiev; I Chourpa; Jean-François Riou; Chi Hung Nguyen; F Lavelle; Michel Manfait
Molecular interactions of DNA-topoisomerase I and II inhibitor with DNA and topoisomerases and in ternary complexes: binding modes and biological effects for intoplicine derivatives.
Biochemistry 1994;33(30):9013-23.
1993: Jean-François Riou; P Fossé; Chi Hung Nguyen; Annette K Larsen; MC Bissery; L Grondard; JM Saucier; Emile Bisagni; F Lavelle
Intoplicine (RP 60475) and its derivatives, a new class of antitumor agents inhibiting both topoisomerase I and II activities.
Cancer research 1993;53(24):5987-93.
1993: Annette K Larsen; L Grondard; J Couprie; B Desoize; L Comoe; J C Jardillier; Jean-François Riou
The antileukemic alkaloid fagaronine is an inhibitor of DNA topoisomerases I and II.
Biochemical pharmacology 1993;46(8):1403-12.
1993: Hamid Morjani; Jean-François Riou; Igor Nabiev; F Lavelle; Michel Manfait
Molecular and cellular interactions between intoplicine, DNA, and topoisomerase II studied by surface-enhanced Raman scattering spectroscopy.
Cancer research 1993;53(20):4784-90.
1993: Jean-François Riou; L Grondard; O Petitgenet; M Abitbol; F Lavelle
Altered topoisomerase I activity and recombination activating gene expression in a human leukemia cell line resistant to doxorubicin.
Biochemical pharmacology 1993;46(5):851-61.
1993: I Madelaine; sandrine prost; A Naudin; G Riou; F Lavelle; Jean-François Riou
Sequential modifications of topoisomerase I activity in a camptothecin-resistant cell line established by progressive adaptation.
Biochemical pharmacology 1993;45(2):339-48.
1992: Jean-François Riou; A Naudin; F Lavelle
Effects of Taxotere on murine and human tumor cell lines.
Biochemical and biophysical research communications 1992;187(1):164-70.
1992: Chi Hung Nguyen; F Lavelle; Jean-François Riou; MC Bissery; C Huel; Emile Bisagni
Further SAR in the new antitumor 1-amino-substituted gamma-carbolines and 5H-benzo[e]pyrido[4,3-b]indoles series.
Anti-cancer drug design 1992;7(3):235-51.
1991: Jean-François Riou; P Helissey; L Grondard; S Giorgi-Renault
Inhibition of eukaryotic DNA topoisomerase I and II activities by indoloquinolinedione derivatives.
Molecular pharmacology 1991;40(5):699-706.
1991: D Lefevre; Jean-François Riou; J C Ahomadegbe; D Y Zhou; J Benard; G Riou
Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line. Decrease of topoisomerase II and increase of both topoisomerase I and acidic glutathione S transferase.
Biochemical pharmacology 1991;41(12):1967-79.
1990: A Báez; Jean-François Riou; J B Le Pecq; G Riou
Interaction of DNA intercalator 3-nitrobenzothiazolo (3,2-a)quinolinium with DNA topoisomerases: a possible-mechanism for its biological activity.
Molecular pharmacology 1990;37(3):377-82.
1989: Jean-François Riou; D Lefevre; G Riou
Stimulation of the topoisomerase II induced DNA cleavage sites in the c-myc protooncogene by antitumor drugs is associated with gene expression.
Biochemistry 1989;28(23):9104-10.
1989: E Multon; Jean-François Riou; D LeFevre; J C Ahomadegbe; G Riou
Topoisomerase II-mediated DNA cleavage activity induced by ellipticines on the human tumor cell line N417.
Biochemical pharmacology 1989;38(13):2077-86.
1988: S Douc-Rasy; Jean-François Riou; J C Ahomadegbe; G Riou
ATP-independent DNA topoisomerase II as potential drug target in trypanosomes.
Biology of the cell / under the auspices of the European Cell Biology Organization 1988;64(2):145-56.
1987: M J Vilarem; Jean-François Riou; G Riou; C J Larsen
[Study, at the gene level, of the activation of topoisomerase II by antitumor agents].
Pathologie-biologie 1987;35(9):1263-9.
1987: Jean-François Riou; M J Vilarem; C J Larsen; E Multon; G Riou
In vivo and in vitro stimulation by antitumor drugs of the topoisomerase II-induced cleavage sites in c-myc proto-oncogene.
NCI monographs : a publication of the National Cancer Institute 1987;(4):41-7.
1986: Jean-François Riou; M J Vilarem; C J Larsen; G Riou
Characterization of the topoisomerase II-induced cleavage sites in the c-myc proto-oncogene. In vitro stimulation by the antitumoral intercalating drug mAMSA.
Biochemical pharmacology 1986;35(24):4409-13.
1986: S Douc-Rasy; A Kayser; Jean-François Riou; G Riou
ATP-independent type II topoisomerase from trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(19):7152-6.
1986: M J Vilarem; Jean-François Riou; E Multon; M P Gras; C J Larsen
The in vitro involvement of topoisomerase II in the activity of aza-ellipticine analogues is not correlated with drug activity on isolated nuclei.
Biochemical pharmacology 1986;35(13):2087-95.
1986: Jean-François Riou; E Multon; M J Vilarem; C J Larsen; G Riou
In vivo stimulation by antitumor drugs of the topoisomerase II induced cleavage sites in c-myc protooncogene.
Biochemical and biophysical research communications 1986;137(1):154-60.
1986: S Douc-Rasy; Jean-François Riou; A Kayser; G Riou
[A DNA topoisomerase from trypanosomes able to catenate, decatenate and unknot DNA without ATP].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1986;302(8):283-6.