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Thomas Bickle

Research Profile

Chemicals & Drugs

Living Beings

Escherichia coli

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Phenomena

Methylation

Genes & Molecular Sequences

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Cloning, Molecular

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Publications

TOP 3
Eva Jindrova; Stefanie Schmid Nuoffer; Fabienne Hamburger; Pavel Janscak; Thomas A Bickle
On the DNA cleavage mechanism of Type I restriction enzymes.
Thomas A Bickle
Restricting restriction.
Luke Peakman; Massimo Antognozzi; Thomas A Bickle; Pavel Janscak; Mark D Szczelkun
S-adenosyl methionine prevents promiscuous DNA cleavage by the EcoP1I type III restriction enzyme.

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All Publications

2005: Eva Jindrova; Stefanie Schmid Nuoffer; Fabienne Hamburger; Pavel Janscak; Thomas A Bickle
On the DNA cleavage mechanism of Type I restriction enzymes.
Nucleic acids research 2005;33(6):1760-6.
2004: Thomas A Bickle
Restricting restriction.
Molecular microbiology 2004;51(1):3-5.
2003: Luke Peakman; Massimo Antognozzi; Thomas A Bickle; Pavel Janscak; Mark D Szczelkun
S-adenosyl methionine prevents promiscuous DNA cleavage by the EcoP1I type III restriction enzyme.
Journal of molecular biology 2003;333(2):321-35.
2003: Christoph Meyer; Dominik Meyer; Thomas A Bickle; Bernd Giese
Chemical restriction: strand cleavage by ammonia treatment at 8-oxoguanine yields biologically active DNA.
Chembiochem : a European journal of chemical biology 2003;4(7):610-4.
2003: Pavel Janscak; Patrick L Garcia; Fabienne Hamburger; Yoko Makuta; Kouya Shiraishi; Yukiho Imai; Hideo Ikeda; Thomas A Bickle
Characterization and mutational analysis of the RecQ core of the bloom syndrome protein.
Journal of molecular biology 2003;330(1):29-42.
2002: Aude A Bourniquel; Thomas A Bickle
Complex restriction enzymes: NTP-driven molecular motors.
Biochimie 2002;84(11):1047-59.
2002: Mark Murphy; Stefanie Schmid Nuoffer; Thomas A Bickle
Lack of regulation of the modification-dependent restriction enzyme McrBC in Escherichia coli.
Journal of bacteriology 2002;184(6):1794-5.
2002: Adrian Dussy; Christoph Meyer; Edith Quennet; Thomas A Bickle; Bernd Giese; Andreas Marx
New light-sensitive nucleosides for caged DNA strand breaks.
Chembiochem : a European journal of chemical biology 2002;3(1):54-60.
2001: Daniel Panne; Shirley A Müller; S Wirtz; Andreas Engel; Thomas A Bickle
The McrBC restriction endonuclease assembles into a ring structure in the presence of G nucleotides.
The EMBO journal 2001;20(12):3210-7.
2001: Pavel Janscak; U Sandmeier; Mark D Szczelkun; Thomas A Bickle
Subunit assembly and mode of DNA cleavage of the type III restriction endonucleases EcoP1I and EcoP15I.
Journal of molecular biology 2001;306(3):417-31.
2000: FJ Stewart; Daniel Panne; Thomas A Bickle; Elisabeth A Raleigh
Methyl-specific DNA binding by McrBC, a modification-dependent restriction enzyme.
Journal of molecular biology 2000;298(4):611-22.
2000: Pavel Janscak; Thomas A Bickle
DNA supercoiling during ATP-dependent DNA translocation by the type I restriction enzyme EcoAI.
Journal of molecular biology 2000;295(4):1089-99.
1999: Daniel Panne; Elisabeth A Raleigh; Thomas A Bickle
The McrBC endonuclease translocates DNA in a reaction dependent on GTP hydrolysis.
Journal of molecular biology 1999;290(1):49-60.
1999: Pavel Janscak; U Sandmeier; Thomas A Bickle
Single amino acid substitutions in the HsdR subunit of the type IB restriction enzyme EcoAI uncouple the DNA translocation and DNA cleavage activities of the enzyme.
Nucleic acids research 1999;27(13):2638-43.
1999: Pavel Janscak; M P MacWilliams; U Sandmeier; V Nagaraja; Thomas A Bickle
DNA translocation blockage, a general mechanism of cleavage site selection by type I restriction enzymes.
The EMBO journal 1999;18(9):2638-47.
1999: Andreas Marx; M Spichty; Mario Amacker; U Schwitter; Ulrich Hübscher; Thomas A Bickle; giovanni maga; Bernd Giese
Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides.
Chemistry & biology 1999;6(2):111-6.
1998: Pavel Janscak; Thomas A Bickle
The DNA recognition subunit of the type IB restriction-modification enzyme EcoAI tolerates circular permutions of its polypeptide chain.
Journal of molecular biology 1998;284(4):937-48.
1998: Daniel Panne; Elisabeth A Raleigh; Thomas A Bickle
McrBs, a modulator peptide for McrBC activity.
The EMBO journal 1998;17(18):5477-83.
1998: Andreas Marx; Mario Amacker; M Stucki; Ulrich Hübscher; Thomas A Bickle; Bernd Giese
4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase.
Nucleic acids research 1998;26(17):4063-7.
1997: C Tyndall; H Lehnherr; U Sandmeier; Eva M Kulik; Thomas A Bickle
The type IC hsd loci of the enterobacteria are flanked by DNA with high homology to the phage P1 genome: implications for the evolution and spread of DNA restriction systems.
Molecular microbiology 1997;23(4):729-36.
1996: E M Kulik; Thomas A Bickle
Regulation of the activity of the type IC EcoR124I restriction enzyme.
Journal of molecular biology 1996;264(5):891-906.
1996: J Dreier; M P MacWilliams; Thomas A Bickle
DNA cleavage by the type IC restriction-modification enzyme EcoR124II.
Journal of molecular biology 1996;264(4):722-33.
1996: M P MacWilliams; Thomas A Bickle
Generation of new DNA binding specificity by truncation of the type IC EcoDXXI hsdS gene.
The EMBO journal 1996;15(17):4775-83.
1996: J Dreier; Thomas A Bickle
ATPase activity of the type IC restriction-modification system EcoR124II.
Journal of molecular biology 1996;257(5):960-9.
1996: N Redaschi; Thomas A Bickle
Posttranscriptional regulation of EcoP1I and EcoP15I restriction activity.
Journal of molecular biology 1996;257(4):790-803.
1994: C Tyndall; J Meister; Thomas A Bickle
The Escherichia coli prr region encodes a functional type IC DNA restriction system closely integrated with an anticodon nuclease gene.
Journal of molecular biology 1994;237(3):266-74.
1993: J Meister; M MacWilliams; P Hübner; H Jütte; E Skrzypek; Andrzej Piekarowicz; Thomas A Bickle
Macroevolution by transposition: drastic modification of DNA recognition by a type I restriction enzyme following Tn5 transposition.
The EMBO journal 1993;12(12):4585-91.
1993: P Hübner; Bernd Masepohl; Werner Klipp; Thomas A Bickle
nif gene expression studies in Rhodobacter capsulatus: ntrC-independent repression by high ammonium concentrations.
Molecular microbiology 1993;10(1):123-32.
1993: Thomas A Bickle; D H Krüger
Biology of DNA restriction.
Microbiological reviews 1993;57(2):434-50.
1992: PJ Preker; P Hübner; M Schmehl; Werner Klipp; Thomas A Bickle
Mapping and characterization of the promoter elements of the regulatory nif genes rpoN, nifA1 and nifA2 in Rhodobacter capsulatus.
Molecular microbiology 1992;6(8):1035-47.
1992: M Gubler; D Braguglia; J Meyer; Andrzej Piekarowicz; Thomas A Bickle
Recombination of constant and variable modules alters DNA sequence recognition by type IC restriction-modification enzymes.
The EMBO journal 1992;11(1):233-40.
1991: P Hübner; John Willison; Paulette M Vignais; Thomas A Bickle
Expression of regulatory nif genes in Rhodobacter capsulatus.
Journal of bacteriology 1991;173(9):2993-9.
1991: M Gubler; Thomas A Bickle
Increased protein flexibility leads to promiscuous protein--DNA interactions in type IC restriction-modification systems.
The EMBO journal 1991;10(4):951-7.
1990: P Linder; R Doelz; M Gubler; Thomas A Bickle
An anticodon nuclease gene inserted into a hsd region encoding a type I DNA restriction system.
Nucleic acids research 1990;18(23):7170.
1989: D N Rao; M G Page; Thomas A Bickle
Cloning, over-expression and the catalytic properties of the EcoP15 modification methylase from Escherichia coli.
Journal of molecular biology 1989;209(4):599-606.
1989: D N Rao; H Eberle; Thomas A Bickle
Characterization of mutations of the bacteriophage P1 mod gene encoding the recognition subunit of the EcoP1 restriction and modification system.
Journal of bacteriology 1989;171(5):2347-52.
1989: C Price; J Lingner; Thomas A Bickle; Keith Firman; S W Glover
Basis for changes in DNA recognition by the EcoR124 and EcoR124/3 type I DNA restriction and modification enzymes.
Journal of molecular biology 1989;205(1):115-25.
1989: P Haffter; T Pripfl; Thomas A Bickle
A mutational analysis of the bacteriophage P1 cin recombinase gene: intragenic complementation.
Molecular & general genetics : MGG 1989;215(2):245-9.
1988: C Price; Thomas A Bickle
Evolution of DNA sequence specificity in type I restriction enzymes.
Biochemical Society transactions 1988;16(6):942-3.
1988: P Haffter; Thomas A Bickle
Enhancer-independent mutants of the Cin recombinase have a relaxed topological specificity.
The EMBO journal 1988;7(12):3991-6.
1988: M Hümbelin; B Suri; D N Rao; D P Hornby; H Eberle; T Pripfl; S Kenel; Thomas A Bickle
Type III DNA restriction and modification systems EcoP1 and EcoP15. Nucleotide sequence of the EcoP1 operon, the EcoP15 mod gene and some EcoP1 mod mutants.
Journal of molecular biology 1988;200(1):23-9.
1987: P Haffter; Thomas A Bickle
Purification and DNA-binding properties of FIS and Cin, two proteins required for the bacteriophage P1 site-specific recombination system, cin.
Journal of molecular biology 1987;198(4):579-87.
1987: C Price; T Pripfl; Thomas A Bickle
EcoR124 and EcoR124/3: the first members of a new family of type I restriction and modification systems.
European journal of biochemistry / FEBS 1987;167(1):111-5.
1987: C Price; J C Shepherd; Thomas A Bickle
DNA recognition by a new family of type I restriction enzymes: a unique relationship between two different DNA specificities.
The EMBO journal 1987;6(5):1493-7.
1987: D P Hornby; M Müller; Thomas A Bickle
High level expression of the EcoP1 modification methylase gene and characterisation of the gene product.
Gene 1987;54(2-3):239-45.
1986: R Charczuk; C Tamm; B Suri; Thomas A Bickle
An unusual base pairing between pyrimidine and pyridine nucleotides.
Nucleic acids research 1986;14(23):9530.
1986: C Price; Thomas A Bickle
A possible role for DNA restriction in bacterial evolution.
Microbiological sciences 1986;3(10):296-9.
1985: B Suri; Thomas A Bickle
EcoA: the first member of a new family of type I restriction modification systems. Gene organization and enzymatic activities.
Journal of molecular biology 1985;186(1):77-85.
1985: V Nagaraja; J C Shepherd; Thomas A Bickle
A hybrid recognition sequence in a recombinant restriction enzyme and the evolution of DNA sequence specificity.
Nature 1985;316(6026):371-2.
1985: H E Huber; S Iida; Werner Arber; Thomas A Bickle
Site-specific DNA inversion is enhanced by a DNA sequence element in cis.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(11):3776-80.
1985: V Nagaraja; J C Shepherd; T Pripfl; Thomas A Bickle
Two type I restriction enzymes from Salmonella species. Purification and DNA recognition sequences.
Journal of molecular biology 1985;182(4):579-87.
1985: V Nagaraja; M Stieger; C Nager; Sheikh Mumtaz Hadi; Thomas A Bickle
The nucleotide sequence recognised by the Escherichia coli D type I restriction and modification enzyme.
Nucleic acids research 1985;13(2):389-99.
1984: B Suri; J C Shepherd; Thomas A Bickle
The EcoA restriction and modification system of Escherichia coli 15T-: enzyme structure and DNA recognition sequence.
The EMBO journal 1984;3(3):575-9.
1984: B Suri; V Nagaraja; Thomas A Bickle
Bacterial DNA modification.
Current topics in microbiology and immunology 1984;108():1-9.
1982: N E Murray; J A Gough; B Suri; Thomas A Bickle
Structural homologies among type I restriction-modification systems.
The EMBO journal 1982;1(5):535-9.
1981: K Ineichen; J C Shepherd; Thomas A Bickle
The DNA sequence of the phage lambda genome between PL and the gene bet.
Nucleic acids research 1981;9(18):4639-53.
1981: Andrzej Piekarowicz; Thomas A Bickle; J C Shepherd; K Ineichen
The DNA sequence recognised by the HinfIII restriction endonuclease.
Journal of molecular biology 1981;146(1):167-72.
1980: Thomas A Bickle; K Ineichen
The DNA sequence recognised by BglI.
Gene 1980;9(3-4):205-12.