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Jeffrey Robbins

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Arthur J Michalek; Michael J Previs; Jeffrey Robbins; Paul R Rosevear; James Gulick; Jack W Howarth; David M Warshaw
Phosphorylation modulates the mechanical stability of the cardiac myosin-binding protein C motif.
Yuan Wang; Martin M LeWinter; Andrew T Lombardo; David Wayne Maughan; Jeffrey Robbins; Bertrand C W Tanner; Sarah M Tremble; Peter VanBuren; Bradley M Palmer
Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticity.
Abbey E Weith; James Gulick; Gregory J Hoeprich; Michael J Previs; Samantha Beck Previs; Jeffrey Robbins; David M Warshaw
The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded manner.

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All Publications

2013: Arthur J Michalek; Michael J Previs; Jeffrey Robbins; Paul R Rosevear; James Gulick; Jack W Howarth; David M Warshaw
Phosphorylation modulates the mechanical stability of the cardiac myosin-binding protein C motif.
Biophysical journal 2013;104(2):442-52.
2013: Yuan Wang; Martin M LeWinter; Andrew T Lombardo; David Wayne Maughan; Jeffrey Robbins; Bertrand C W Tanner; Sarah M Tremble; Peter VanBuren; Bradley M Palmer
Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticity.
Journal of molecular and cellular cardiology 2013;54():1-8.
2012: Abbey E Weith; James Gulick; Gregory J Hoeprich; Michael J Previs; Samantha Beck Previs; Jeffrey Robbins; David M Warshaw
The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded manner.
Journal of muscle research and cell motility 2012;33(6):449-59.
2012: M J Previs; Jeffrey Robbins; S Beck Previs; J Gulick; David M Warshaw
Molecular mechanics of cardiac myosin-binding protein C in native thick filaments.
Science (New York, N.Y.) 2012;337(6099):1215-8.
2012: Jeffrey M Lynch; Kaari A Lynch; Marjorie Maillet; Bruce J Aronow; N Scott Blair; Jack Lawler; John N Lorenz; Kazutoshi Mori; Tetsuya Okada; Hanna Osinska; Ron Prywes; Jeffrey Robbins; Michelle A Sargent; Aryn Schloemer; Davy Vanhoutte; Jeffery D Molkentin
A thrombospondin-dependent pathway for a protective ER stress response.
Cell 2012;149(6):1257-68.
2012: Michael Tranter; Xiaoping Ren; Jeffrey Robbins; James Gulick; Suiwen He; W Keith Jones; Yemin Liu; Theresa M Reineke
In vivo delivery of nucleic acids via glycopolymer vehicles affords therapeutic infarct size reduction in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(3):601-8.
2012: Kobra Haghighi; Ahmad Anjak; Donald M Bers; Julie Bossuyt; Guo-Chang Fan; Hanna Osinska; Tracy Pritchard; Jeffrey Robbins; Jack Rubinstein; Jason R Waggoner; Qunying Yuan; Evangelia G Kranias
The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase.
Journal of molecular and cellular cardiology 2012;52(3):773-82.
2011: Bradley M Palmer; Michael J Previs; Jeffrey Robbins; Sakthivel Sadayappan; Yuan Wang; Abbey E Weith; Tanya Bekyarova; Thomas C Irving; David Wayne Maughan
Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime.
Biophysical journal 2011;101(7):1661-9.
2011: Patrick M McLendon; Jeffrey Robbins
Desmin-related cardiomyopathy: an unfolding story.
American journal of physiology. Heart and circulatory physiology 2011;301(4):H1220-8.
2011: J Scott Pattison; Jeffrey Robbins
Autophagy and proteotoxicity in cardiomyocytes.
Autophagy 2011;7(10):1259-60.
2011: Jeffrey Robbins
Twenty years of gene targeting: what we don't know.
Circulation research 2011;109(7):722-3.
2011: J Scott Pattison; Hanna Osinska; Jeffrey Robbins
Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes.
Circulation research 2011;109(2):151-60.
2011: Sakthivel Sadayappan; Metin Avkiran; David Barefield; Donald M Bers; Joan Heller Brown; Friederike Cuello; James Gulick; Jeanne James; Valerie M Lasko; John N Lorenz; Marjorie Maillet; Jody L Martin; Jeffery D Molkentin; Hanna Osinska; Jeffrey Robbins
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function.
Circulation research 2011;109(2):141-50.
2011: Jeanne James; Jeffrey Robbins
At the source: treating heart failure by altering muscle motor function.
Circulation research 2011;109(1):5-7.
2011: Jeanne James; Jeffrey Robbins
Signaling and myosin-binding protein C.
The Journal of biological chemistry 2011;286(12):9913-9.
2010: Joerg Heineke; Kai C Wollert; Hanna Osinska; Michelle A Sargent; Allen York; Jeffrey Robbins; Jeffery D Molkentin
Calcineurin protects the heart in a murine model of dilated cardiomyopathy.
Journal of molecular and cellular cardiology 2010;48(6):1080-7.
2010: Alina Maloyan; Jennifer Sayegh; Hanna Osinska; Balvin H L Chua; Jeffrey Robbins
Manipulation of death pathways in desmin-related cardiomyopathy.
Circulation research 2010;106(9):1524-32.
2010: Jeanne James; Kan Hor; Michael-Alice Moga; Lisa Ann Martin; Jeffrey Robbins
Effects of myosin heavy chain manipulation in experimental heart failure.
Journal of molecular and cellular cardiology 2010;48(5):999-1006.
2010: Marjorie Maillet; Jennifer Davis; Mannix Auger-Messier; Allen York; Hanna Osinska; Jérôme Piquereau; John N Lorenz; Jeffrey Robbins; Renée Ventura-Clapier; Jeffery D Molkentin
Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function.
The Journal of biological chemistry 2010;285(9):6716-24.
2010: Sonya C Bardswell; Friederike Cuello; Alexandra J Rowland; Sakthivel Sadayappan; Jeffrey Robbins; Mathias Gautel; Jeffery W Walker; Jonathan C Kentish; Metin Avkiran
Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling.
The Journal of biological chemistry 2010;285(8):5674-82.
2010: David Terrell; Jeffrey Robbins
Protein conformation-based disease: getting to the heart of the matter.
Annual review of physiology 2010;72():15-7.
2009: Tomoki Nakamura; James Gulick; Ronald Pratt; Jeffrey Robbins
Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(36):15436-41.
2009: Tomoki Nakamura; James Gulick; Melissa C Colbert; Jeffrey Robbins
Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11270-5.
2009: Persoulla Nicolaou; Patricia Rodriguez; Xiaoping Ren; Xiaoyang Zhou; Jiang Qian; Sakthivel Sadayappan; Bryan Mitton; Anand Pathak; Jeffrey Robbins; Roger J Hajjar; Keith Jones; Evangelia G Kranias
Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.
Circulation research 2009;104(8):1012-20.
2009: Alina Maloyan; Hanna Osinska; Jan Lammerding; Richard T Lee; Oscar Horacio Cingolani; David A Kass; John N Lorenz; Jeffrey Robbins
Biochemical and mechanical dysfunction in a mouse model of desmin-related myopathy.
Circulation research 2009;104(8):1021-8.
2009: Sakthivel Sadayappan; James Gulick; Raisa Klevitsky; John N Lorenz; Michelle Sargent; Jeffery D Molkentin; Jeffrey Robbins
Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.
Circulation 2009;119(9):1253-62.
2009: Jeffery D Molkentin; Jeffrey Robbins
With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure.
Journal of molecular and cellular cardiology 2009;46(2):130-6.
2009: James Gulick; Jeffrey Robbins
Cell-type-specific transgenesis in the mouse.
Methods in molecular biology (Clifton, N.J.) 2009;561():91-104.
2008: Maike Krenz; James Gulick; Hanna Osinska; Melissa C Colbert; Jeffery D Molkentin; Jeffrey Robbins
Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18930-5.
2008: J Scott Pattison; Jeffrey Robbins
Protein misfolding and cardiac disease: establishing cause and effect.
Autophagy 2008;4(6):821-3.
2008: Michael-Alice Moga; Tomoki Nakamura; Jeffrey Robbins
Genetic approaches for changing the heart and dissecting complex syndromes.
Journal of molecular and cellular cardiology 2008;45(2):148-55.
2008: J Scott Pattison; Atsushi Sanbe; Alina Maloyan; Hanna Osinska; Raisa Klevitsky; Jeffrey Robbins
Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure.
Circulation 2008;117(21):2743-51.
2008: Douglas P Millay; Michelle A Sargent; Hanna Osinska; Christopher P Baines; Elisabeth R Barton; Grégoire Vuagniaux; H Lee Sweeney; Jeffrey Robbins; Jeffery D Molkentin
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.
Nature medicine 2008;14(4):442-7.
2008: Sakthivel Sadayappan; Natosha L Finley; Jack W Howarth; Hanna Osinska; Raisa Klevitsky; John N Lorenz; Paul R Rosevear; Jeffrey Robbins
Role of the acidic N' region of cardiac troponin I in regulating myocardial function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(4):1246-57.
2008: James Scott Pattison; Jason R Waggoner; Jeanne James; Lisa Martin; James Gulick; Hanna Osinska; Raisa Klevitsky; Evangelia G Kranias; Jeffrey Robbins
Phospholamban overexpression in transgenic rabbits.
Transgenic research 2008;17(2):157-70.
2008: Sakthivel Sadayappan; Jeffrey Robbins
The death of transcriptional chauvinism in the control and regulation of cardiac contractility.
Annals of the New York Academy of Sciences 2008;1123():1-9.
2007: Michael Hambleton; Allen York; Michelle A Sargent; Robert A Kaiser; John N Lorenz; Jeffrey Robbins; Jeffery D Molkentin
Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure.
American journal of physiology. Heart and circulatory physiology 2007;293(6):H3768-71.
2007: Takahiro Nagayama; Eiki Takimoto; Sakthivel Sadayappan; James OTIS Mudd; Jonathan G Seidman; Jeffrey Robbins; David A Kass
Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation.
Circulation 2007;116(21):2399-408.
2007: Jörg Heineke; Mannix Auger-Messier; Jian Xu; Toru Oka; Michelle A Sargent; Allen York; Raisa Klevitsky; Sachin Vaikunth; Stephen A Duncan; Bruce Aronow; Jeffrey Robbins; Timothy M Crombleholme; Timothy M Cromblehol; Jeffery D Molkentin
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart.
The Journal of clinical investigation 2007;117(11):3198-210.
2007: Abhinav Diwan; Maike Krenz; Faisal M Syed; Janaka Wansapura; Xiaoping Ren; Andrew G Koesters; Hairong Li; Lorrie A Kirshenbaum; Harvey S Hahn; Jeffrey Robbins; W Keith Jones; Gerald W Dorn
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice.
The Journal of clinical investigation 2007;117(10):2825-33.
2007: Hiroyuki Nakayama; Xiongwen Chen; Christopher P Baines; Raisa Klevitsky; Xiaoying Zhang; Hongyu Zhang; Naser Jaleel; Balvin H L Chua; Timothy E Hewett; Jeffrey Robbins; Steven R Houser; Jeffery D Molkentin
Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.
The Journal of clinical investigation 2007;117(9):2431-44.
2007: Nicole H Purcell; Benjamin J Wilkins; Allen York; Marc K Saba-El-Leil; Sylvain Meloche; Jeffrey Robbins; Jeffery D Molkentin
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14074-9.
2007: So-ichiro Yasuda; Pierre Coutu; Sakthivel Sadayappan; Jeffrey Robbins; Joseph M Metzger
Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes.
Circulation research 2007;101(4):377-86.
2007: Maike Krenz; Sakthivel Sadayappan; Hanna Osinska; Jeffrey A Henry; Samantha Beck; David M Warshaw; Jeffrey Robbins
Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart.
The Journal of biological chemistry 2007;282(33):24057-64.
2007: Toru Oka; Jian Xu; Robert A Kaiser; Jaime Melendez; Michael Hambleton; Michelle A Sargent; Angela Lorts; Eric W Brunskill; Gerald W Dorn; Simon J Conway; Bruce Aronow; Jeffrey Robbins; Jeffery D Molkentin
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling.
Circulation research 2007;101(3):313-21.
2007: Tomoki Nakamura; Melissa C Colbert; Maike Krenz; Jeffery D Molkentin; Harvey S Hahn; Gerald W Dorn; Jeffrey Robbins
Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.
The Journal of clinical investigation 2007;117(8):2123-32.
2007: Anita S Galvez; Abhinav Diwan; Amy Odley; Harvey S Hahn; Hanna Osinska; Jaime G Melendez; Jeffrey Robbins; Roy A Lynch; Yehia Marreez; Gerald W Dorn
Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis.
Circulation research 2007;100(7):1071-8.
2007: Alina Maloyan; James Gulick; Charles G Glabe; Rakez Kayed; Jeffrey Robbins
Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5995-6000.
2007: Katherine E Yutzey; Jeffrey Robbins
Principles of genetic murine models for cardiac disease.
Circulation 2007;115(6):792-9.
2006: Sakthivel Sadayappan; Hanna Osinska; Raisa Klevitsky; John N Lorenz; Michelle A Sargent; Jeffery D Molkentin; Christine E Seidman; Jonathan G Seidman; Jeffrey Robbins
Cardiac myosin binding protein C phosphorylation is cardioprotective.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16918-23.
2006: Hao Wang; Jennifer E Grant; Christopher M Doede; Sakthivel Sadayappan; Jeffrey Robbins; Jeffery W Walker
PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144.
Journal of molecular and cellular cardiology 2006;41(5):823-33.
2006: Robert Gaffin; Kuppan Gokulan; James C Sacchettini; Timothy E Hewett; Raisa Klevitsky; Jeffrey Robbins; Vandana Sarin; David C Zawieja; Gerald A Meininger; Mariappan Muthuchamy
Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H552-63.
2006: Takao Nishizawa; Stephen F Vatner; Chull Hong; You-Tang Shen; Stefan E Hardt; Jeffrey Robbins; Yoshihiro Ishikawa; Junichi Sadoshima; Dorothy E Vatner
Overexpressed cardiac Gsalpha in rabbits.
Journal of molecular and cellular cardiology 2006;41(1):44-50.
2006: Tomoki Nakamura; Melissa C Colbert; Jeffrey Robbins
Neural crest cells retain multipotential characteristics in the developing valves and label the cardiac conduction system.
Circulation research 2006;98(12):1547-54.
2006: Yvonne N Tallini; Masamichi Ohkura; Bum-Rak Choi; Guangju Ji; Keiji Imoto; Robert Doran; Jane Lee; Patricia Plan; Jason Wilson; Hong-Bo Xin; Atsushi Sanbe; James Gulick; John Mathai; Jeffrey Robbins; Guy Salama; Junichi Nakai; Michael I Kotlikoff
Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4753-8.
2005: Katherine E Yutzey; Melissa C Colbert; Jeffrey Robbins
Ras-related signaling pathways in valve development: ebb and flow.
Physiology (Bethesda, Md.) 2005;20():390-7.
2005: Alina Maloyan; Atsushi Sanbe; Hanna Osinska; Margaret V Westfall; Dustin Robinson; Kenichi Imahashi; Elizabeth Murphy; Jeffrey Robbins
Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy.
Circulation 2005;112(22):3451-61.
2005: Sakthivel Sadayappan; James Gulick; Hanna Osinska; Lisa A Martin; Harvey S Hahn; Gerald W Dorn; Raisa Klevitsky; Christine E Seidman; Jonathan G Seidman; Jeffrey Robbins
Cardiac myosin-binding protein-C phosphorylation and cardiac function.
Circulation research 2005;97(11):1156-63.
2005: Maike Krenz; Katherine E Yutzey; Jeffrey Robbins
Noonan syndrome mutation Q79R in Shp2 increases proliferation of valve primordia mesenchymal cells via extracellular signal-regulated kinase 1/2 signaling.
Circulation research 2005;97(8):813-20.
2005: Mark S Miller; Bradley M Palmer; Stuart Ruch; Lisa A Martin; Gerrie P Farman; Yuan Wang; Jeffrey Robbins; Thomas C Irving; David Wayne Maughan
The essential light chain N-terminal extension alters force and fiber kinetics in mouse cardiac muscle.
The Journal of biological chemistry 2005;280(41):34427-34.
2005: Atsushi Sanbe; Hanna Osinska; Chet Villa; James Gulick; Raisa Klevitsky; Charles G Glabe; Rakez Kayed; Jeffrey Robbins
Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13592-7.
2005: James Gulick; Jeffrey Robbins
Regulation of transgene expression using tetracycline.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2005;Chapter 23():Unit 23.12.
2005: Jeanne James; Lisa Martin; Maike Krenz; Carmen Quatman; Fred Jones; Raisa Klevitsky; James Gulick; Jeffrey Robbins
Forced expression of alpha-myosin heavy chain in the rabbit ventricle results in cardioprotection under cardiomyopathic conditions.
Circulation 2005;111(18):2339-46.
2005: Atsushi Sanbe; Jeanne James; Volkan Tuzcu; Selman Nas; Lisa Martin; James Gulick; Hanna Osinska; Sadayappan Sakthivel; Raisa Klevitsky; Kenneth S Ginsburg; Donald M Bers; Bruce Zinman; Edward G Lakatta; Jeffrey Robbins
Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy.
Circulation 2005;111(18):2330-8.
2005: Christopher P Baines; Robert A Kaiser; Nicole H Purcell; N Scott Blair; Hanna Osinska; Michael Hambleton; Eric W Brunskill; M Richard Sayen; Roberta Anne Gottlieb; Gerald W Dorn; Jeffrey Robbins; Jeffery D Molkentin
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death.
Nature 2005;434(7033):658-62.
2005: Sadayappan Sakthivel; Natosha L Finley; Paul R Rosevear; John N Lorenz; James Gulick; Scott Kim; Peter VanBuren; Lisa A Martin; Jeffrey Robbins
In vivo and in vitro analysis of cardiac troponin I phosphorylation.
The Journal of biological chemistry 2005;280(1):703-14.
2004: Maike Krenz; Jeffrey Robbins
Impact of beta-myosin heavy chain expression on cardiac function during stress.
Journal of the American College of Cardiology 2004;44(12):2390-7.
2004: Robert Gaffin; Carl W Tong; David C Zawieja; Timothy E Hewett; Raisa Klevitsky; Jeffrey Robbins; Mariappan Muthuchamy
Charged residue alterations in the inner-core domain and carboxy-terminus of alpha-tropomyosin differentially affect mouse cardiac muscle contractility.
The Journal of physiology 2004;561(Pt 3):777-91.
2004: Faisal M Syed; Amy Odley; Harvey S Hahn; Eric W Brunskill; Roy A Lynch; Yehia Marreez; Atsushi Sanbe; Jeffrey Robbins; Gerald W Dorn
Physiological growth synergizes with pathological genes in experimental cardiomyopathy.
Circulation research 2004;95(12):1200-6.
2004: A Kumar; K Crawford; R Flick; Raisa Klevitsky; John N Lorenz; K E Bove; Jeffrey Robbins; James L Lessard
Transgenic overexpression of cardiac actin in the mouse heart suggests coregulation of cardiac, skeletal and vascular actin expression.
Transgenic research 2004;13(6):531-40.
2004: Atsushi Sanbe; Hanna Osinska; Jeffrey E Saffitz; Charles G Glabe; Rakez Kayed; Alina Maloyan; Jeffrey Robbins
Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10132-6.
2004: Qiujing Song; Karen B Young; Guoxiang Chu; James Gulick; Michael J Gerst; Ingrid L Grupp; Jeffrey Robbins; Evangelia G Kranias
Overexpression of phospholamban in slow-twitch skeletal muscle is associated with depressed contractile function and muscle remodeling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(9):974-6.
2004: Amy Odley; Harvey S Hahn; Roy A Lynch; Yehia Marreez; Hanna Osinska; Jeffrey Robbins; Gerald W Dorn
Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7082-7.
2004: Robert Gaffin; Kuppan Gokulan; James C Sacchettini; Timothy E Hewett; Raisa Klevitsky; Jeffrey Robbins; Mariappan Muthuchamy
Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractility.
The Journal of physiology 2004;556(Pt 2):531-43.
2004: Julian C Braz; Kimberly Gregory; Anand Pathak; Wen Zhao; Bogachan Sahin; Raisa Klevitsky; Thomas F Kimball; John N Lorenz; Angus Nairn; Stephen B Liggett; Ilona Bodi; Su Wang; Arnold Schwartz; Edward G Lakatta; Anna A DePaoli-Roach; Jeffrey Robbins; Timothy E Hewett; James A Bibb; Margaret V Westfall; Evangelia G Kranias; Jeffery D Molkentin
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Nature medicine 2004;10(3):248-54.
2003: Xuejun Wang; Raisa Klevitsky; Wei Huang; Joseph Glasford; Faqian Li; Jeffrey Robbins
AlphaB-crystallin modulates protein aggregation of abnormal desmin.
Circulation research 2003;93(10):998-1005.
2003: Maike Krenz; Atsushi Sanbe; Florence Bouyer-Dalloz; James Gulick; Raisa Klevitsky; Timothy E Hewett; Hanna Osinska; John N Lorenz; Christine Brosseau; Andrea Federico; Norman R Alpert; David M Warshaw; M Benjamin Perryman; Steve M Helmke; Jeffrey Robbins
Analysis of myosin heavy chain functionality in the heart.
The Journal of biological chemistry 2003;278(19):17466-74.
2003: Atsushi Sanbe; James Gulick; Mark C Hanks; Qiangrong Liang; Hanna Osinska; Jeffrey Robbins
Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter.
Circulation research 2003;92(6):609-16.
2002: Xuejun Wang; Hanna Osinska; A Martin Gerdes; Jeffrey Robbins
Desmin filaments and cardiac disease: establishing causality.
Journal of cardiac failure 2002;8(6 Suppl):S287-92.
2002: Harvey S Hahn; Martin G Yussman; Tsuyoshi Toyokawa; Yehia Marreez; Thomas J Barrett; K Chad Hilty; Hanna Osinska; Jeffrey Robbins; Gerald W Dorn
Ischemic protection and myofibrillar cardiomyopathy: dose-dependent effects of in vivo deltaPKC inhibition.
Circulation research 2002;91(8):741-8.
2002: Norman R Alpert; Christine Brosseau; Andrea Federico; Maike Krenz; Jeffrey Robbins; David M Warshaw
Molecular mechanics of mouse cardiac myosin isoforms.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1446-54.
2002: Jeanne James; Yan Zhang; Kathy Wright; Sandra Witt; Elizabeth Glascock; Hanna Osinska; Raisa Klevitsky; Lisa Martin; Karen Yager; Atsushi Sanbe; Jeffrey Robbins
Transgenic rabbits expressing mutant essential light chain do not develop hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 2002;34(7):873-82.
2002: Guoxiang Chu; Andrew N Carr; Karen B Young; J William Lester; Atsuko Yatani; Atsushi Sanbe; Melissa C Colbert; Steven M Schwartz; Konrad Frank; Paul D Lampe; Jeffrey Robbins; Jeffery D Molkentin; Evangelia G Kranias
Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure.
Cardiovascular research 2002;54(1):105-16.
2001: Guangyu Wu; Martin G Yussman; T J Barrett; Harvey S Hahn; Hanna Osinska; George M Hilliard; Xinkang Wang; Tsuyoshi Toyokawa; Atsuko Yatani; Roy A Lynch; Jeffrey Robbins; Gerald W Dorn
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy.
Circulation research 2001;89(12):1130-7.
2001: G Schwartzbauer; Jeffrey Robbins
The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival.
The Journal of biological chemistry 2001;276(38):35786-93.
2001: Q Yang; Hanna Osinska; Raisa Klevitsky; Jeffrey Robbins
Phenotypic deficits in mice expressing a myosin binding protein C lacking the titin and myosin binding domains.
Journal of molecular and cellular cardiology 2001;33(9):1649-58.
2001: Atsushi Sanbe; James Gulick; JG Fewell; Jeffrey Robbins
Examining the in vivo role of the amino terminus of the essential myosin light chain.
The Journal of biological chemistry 2001;276(35):32682-6.
2001: Xuejun Wang; Hanna Osinska; Raisa Klevitsky; A Martin Gerdes; Michelle L Nieman; J Lorenz; T Hewett; Jeffrey Robbins
Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice.
Circulation research 2001;89(1):84-91.
2001: Q Yang; T E Hewett; Raisa Klevitsky; Atsushi Sanbe; X Wang; Jeffrey Robbins
PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice.
Cardiovascular research 2001;51(1):80-8.
2001: F Dalloz; Hanna Osinska; Jeffrey Robbins
[Genetically modified animal models in cardiovascular research].
Revista española de cardiología 2001;54(6):764-89.
2001: Xuejun Wang; Hanna Osinska; Gerald W Dorn; Michelle L Nieman; John N Lorenz; A Martin Gerdes; Sandra Witt; T Kimball; James Gulick; Jeffrey Robbins
Mouse model of desmin-related cardiomyopathy.
Circulation 2001;103(19):2402-7.
2001: F Dalloz; Hanna Osinska; Jeffrey Robbins
Manipulating the contractile apparatus: genetically defined animal models of cardiovascular disease.
Journal of molecular and cellular cardiology 2001;33(1):9-25.
2000: J James; Y Zhang; Hanna Osinska; Atsushi Sanbe; Raisa Klevitsky; Timothy E Hewett; Jeffrey Robbins
Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy.
Circulation research 2000;87(9):805-11.
2000: Atsushi Sanbe; James Gulick; E Hayes; David M Warshaw; Hanna Osinska; C B Chan; Raisa Klevitsky; Jeffrey Robbins
Myosin light chain replacement in the heart.
American journal of physiology. Heart and circulatory physiology 2000;279(3):H1355-64.
2000: Atsushi Sanbe; D Nelson; James Gulick; Elizabeth A Setser; Hanna Osinska; X Wang; Timothy E Hewett; Raisa Klevitsky; E Hayes; David M Warshaw; Jeffrey Robbins
In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy.
Circulation research 2000;87(4):296-302.
2000: D P Nelson; Elizabeth A Setser; DG Hall; S M Schwartz; T Hewitt; Raisa Klevitsky; Hanna Osinska; Donald Bellgrau; R C Duke; Jeffrey Robbins
Proinflammatory consequences of transgenic fas ligand expression in the heart.
The Journal of clinical investigation 2000;105(9):1199-208.
2000: Jeanne James; Atsushi Sanbe; Karen Yager; L Martin; Raisa Klevitsky; Jeffrey Robbins
Genetic manipulation of the rabbit heart via transgenesis.
Circulation 2000;101(14):1715-21.
2000: Jeffrey Robbins
Toward the new millennium.
Annual review of physiology 2000;62():961-3.
2000: Jeffrey Robbins
Remodeling the cardiac sarcomere using transgenesis.
Annual review of physiology 2000;62():261-87.
1999: Q Yang; Atsushi Sanbe; Hanna Osinska; Timothy E Hewett; Raisa Klevitsky; Jeffrey Robbins
In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy.
Circulation research 1999;85(9):841-7.
1999: Atsushi Sanbe; JG Fewell; James Gulick; Hanna Osinska; J Lorenz; D G Hall; L A Murray; T R Kimball; S A Witt; Jeffrey Robbins
Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2.
The Journal of biological chemistry 1999;274(30):21085-94.
1999: Jeanne James; Hanna Osinska; Timothy E Hewett; T Kimball; Raisa Klevitsky; Sandra Witt; D G Hall; James Gulick; Jeffrey Robbins
Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology.
Transgenic research 1999;8(1):9-22.
1998: Q Yang; Atsushi Sanbe; Hanna Osinska; Timothy E Hewett; Raisa Klevitsky; Jeffrey Robbins
A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy.
The Journal of clinical investigation 1998;102(7):1292-300.
1998: Mark A Sussman; HW Lim; Natalie Gude; T Taigen; E N Olson; Jeffrey Robbins; Melissa C Colbert; A Gualberto; D F Wieczorek; Jeffery D Molkentin
Prevention of cardiac hypertrophy in mice by calcineurin inhibition.
Science (New York, N.Y.) 1998;281(5383):1690-3.
1998: JG Fewell; Timothy E Hewett; Atsushi Sanbe; Raisa Klevitsky; E Hayes; David M Warshaw; David Wayne Maughan; Jeffrey Robbins
Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice.
The Journal of clinical investigation 1998;101(12):2630-9.
1998: CM Pawloski-Dahm; G Song; D L Kirkpatrick; J Palermo; James Gulick; Gerald W Dorn; Jeffrey Robbins; Richard A Walsh
Effects of total replacement of atrial myosin light chain-2 with the ventricular isoform in atrial myocytes of transgenic mice.
Circulation 1998;97(15):1508-13.
1998: J F James; Timothy E Hewett; Jeffrey Robbins
Cardiac physiology in transgenic mice.
Circulation research 1998;82(4):407-15.
1997: J James; Jeffrey Robbins
Molecular remodeling of cardiac contractile function.
The American journal of physiology 1997;273(5 Pt 2):H2105-18.
1997: Melissa C Colbert; DG Hall; Thomas R Kimball; Sandra A Witt; John N Lorenz; M L Kirby; T E Hewett; Raisa Klevitsky; Jeffrey Robbins
Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice.
The Journal of clinical investigation 1997;100(8):1958-68.
1997: JG Fewell; Hanna Osinska; Raisa Klevitsky; W Ng; G Sfyris; F Bahrehmand; Jeffrey Robbins
A treadmill exercise regimen for identifying cardiovascular phenotypes in transgenic mice.
The American journal of physiology 1997;273(3 Pt 2):H1595-605.
1997: James Gulick; Timothy E Hewett; Raisa Klevitsky; Scott H Buck; R L Moss; Jeffrey Robbins
Transgenic remodeling of the regulatory myosin light chains in the mammalian heart.
Circulation research 1997;80(5):655-64.
1997: A Kumar; K Crawford; L Close; M Madison; J Lorenz; Thomas Doetschman; Sharon Pawlowski; J Duffy; J Neumann; Jeffrey Robbins; Gregory P Boivin; B A O'Toole; James L Lessard
Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4406-11.
1997: John N Lorenz; Jeffrey Robbins
Measurement of intraventricular pressure and cardiac performance in the intact closed-chest anesthetized mouse.
The American journal of physiology 1997;272(3 Pt 2):H1137-46.
1997: W A Ng; T Doetschman; Jeffrey Robbins; James L Lessard
Muscle isoactin expression during in vitro differentiation of murine embryonic stem cells.
Pediatric research 1997;41(2):285-92.
1996: W K Jones; Ingrid L Grupp; Thomas Doetschman; G Grupp; Hanna Osinska; Timothy E Hewett; G Boivin; James Gulick; W A Ng; Jeffrey Robbins
Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.
The Journal of clinical investigation 1996;98(8):1906-17.
1996: S Knotts; A Sánchez; H Rindt; Jeffrey Robbins
Developmental Modulation of a beta myosin heavy chain promoter-driven transgene.
Developmental dynamics : an official publication of the American Association of Anatomists 1996;206(2):182-92.
1996: Melissa C Colbert; M L Kirby; Jeffrey Robbins
Endogenous retinoic acid signaling colocalizes with advanced expression of the adult smooth muscle myosin heavy chain isoform during development of the ductus arteriosus.
Circulation research 1996;78(5):790-8.
1996: J Palermo; James Gulick; M Colbert; J Fewell; Jeffrey Robbins
Transgenic remodeling of the contractile apparatus in the mammalian heart.
Circulation research 1996;78(3):504-9.
1996: Jeffrey Robbins
Regulation of cardiac gene expression during development.
Cardiovascular research 1996;31 Spec No():E2-16.
1995: H Rindt; A Subramaniam; Jeffrey Robbins
An in vivo analysis of transcriptional elements in the mouse alpha-myosin heavy chain gene promoter.
Transgenic research 1995;4(6):397-405.
1995: S Knotts; H Rindt; Jeffrey Robbins
Position independent expression and developmental regulation is directed by the beta myosin heavy chain gene's 5' upstream region in transgenic mice.
Nucleic acids research 1995;23(16):3301-9.
1995: Jeffrey Robbins; J Palermo; H Rindt
In vivo definition of a cardiac specific promoter and its potential utility in remodeling the heart.
Annals of the New York Academy of Sciences 1995;752():492-505.
1995: H Rindt; S Knotts; Jeffrey Robbins
Segregation of cardiac and skeletal muscle-specific regulatory elements of the beta-myosin heavy chain gene.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1540-4.
1995: J Palermo; James Gulick; W Ng; Ingrid L Grupp; G Grupp; Jeffrey Robbins
Remodeling the mammalian heart using transgenesis.
Cellular & molecular biology research 1995;41(6):501-9.
1994: S Knotts; H Rindt; J Neumann; Jeffrey Robbins
In vivo regulation of the mouse beta myosin heavy chain gene.
The Journal of biological chemistry 1994;269(49):31275-82.
1994: Gerald W Dorn; Jeffrey Robbins; NA Ball; R A Walsh
Myosin heavy chain regulation and myocyte contractile depression after LV hypertrophy in aortic-banded mice.
The American journal of physiology 1994;267(1 Pt 2):H400-5.
1994: W K Jones; A Sánchez; Jeffrey Robbins
Murine pulmonary myocardium: developmental analysis of cardiac gene expression.
Developmental dynamics : an official publication of the American Association of Anatomists 1994;200(2):117-28.
1994: Timothy E Hewett; Ingrid L Grupp; G Grupp; Jeffrey Robbins
Alpha-skeletal actin is associated with increased contractility in the mouse heart.
Circulation research 1994;74(4):740-6.
1994: A Sánchez; Jeffrey Robbins
Unprocessed myogenin transcripts accumulate during mouse embryogenesis.
The Journal of biological chemistry 1994;269(3):1587-90.
1993: Ingrid L Grupp; A Subramaniam; Timothy E Hewett; Jeffrey Robbins; G Grupp
Comparison of normal, hypodynamic, and hyperdynamic mouse hearts using isolated work-performing heart preparations.
The American journal of physiology 1993;265(4 Pt 2):H1401-10.
1993: Jeffrey Robbins
Gene targeting. The precise manipulation of the mammalian genome.
Circulation research 1993;73(1):3-9.
1993: E A Adolph; A Subramaniam; Peter Cserjesi; E N Olson; Jeffrey Robbins
Role of myocyte-specific enhancer-binding factor (MEF-2) in transcriptional regulation of the alpha-cardiac myosin heavy chain gene.
The Journal of biological chemistry 1993;268(8):5349-52.
1993: H Rindt; James Gulick; S Knotts; J Neumann; Jeffrey Robbins
In vivo analysis of the murine beta-myosin heavy chain gene promoter.
The Journal of biological chemistry 1993;268(7):5332-8.
1993: Jeffrey Robbins
Recombinant DNA and gene isolation.
Trends in cardiovascular medicine 1993;3(2):39-43.
1993: A Subramaniam; James Gulick; J Neumann; S Knotts; Jeffrey Robbins
Transgenic analysis of the thyroid-responsive elements in the alpha-cardiac myosin heavy chain gene promoter.
The Journal of biological chemistry 1993;268(6):4331-6.
1993: H Rindt; B J Bauer; Jeffrey Robbins
In vitro production of enzymatically active myosin heavy chain.
Journal of muscle research and cell motility 1993;14(1):26-34.
1992: Jeffrey Robbins; Thomas Doetschman; W K Jones; A Sánchez
Embryonic stem cells as a model for cardiogenesis.
Trends in cardiovascular medicine 1992;2(2):44-50.
1992: J Parker-Thornburg; B Bauer; J Palermo; Jeffrey Robbins
Structural and developmental analysis of two linked myosin heavy chain genes.
Developmental biology 1992;150(1):99-107.
1991: A Subramaniam; W K Jones; James Gulick; Susan E Wert; J Neumann; Jeffrey Robbins
Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.
The Journal of biological chemistry 1991;266(36):24613-20.
1991: A Sánchez; W K Jones; James Gulick; Thomas Doetschman; Jeffrey Robbins
Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study.
The Journal of biological chemistry 1991;266(33):22419-26.
1991: W A Ng; Ingrid L Grupp; A Subramaniam; Jeffrey Robbins
Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.
Circulation research 1991;68(6):1742-50.
1991: J J McAuliffe; Jeffrey Robbins
Troponin T expression in normal and pressure-loaded fetal sheep heart.
Pediatric research 1991;29(6):580-5.
1991: James Gulick; A Subramaniam; J Neumann; Jeffrey Robbins
Isolation and characterization of the mouse cardiac myosin heavy chain genes.
The Journal of biological chemistry 1991;266(14):9180-5.
1990: A Subramaniam; James Gulick; Jeffrey Robbins
Analysis of the upstream regulatory region of a chicken skeletal myosin heavy chain gene.
The Journal of biological chemistry 1990;265(23):13986-94.
1990: Jeffrey Robbins; James Gulick; A Sanchez; Philip N Howles; Thomas Doetschman
Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.
The Journal of biological chemistry 1990;265(20):11905-9.
1990: H V de Silva; Judith A K Harmony; William D Stuart; C M Gil; Jeffrey Robbins
Apolipoprotein J: structure and tissue distribution.
Biochemistry 1990;29(22):5380-9.
1989: Jeffrey Robbins; A Subramaniam; James Gulick
A multipurpose vector for the study of transcriptional control.
Gene 1989;85(2):541-4.
1987: K E Kropp; James Gulick; Jeffrey Robbins
Structural and transcriptional analysis of a chicken myosin heavy chain gene subset.
The Journal of biological chemistry 1987;262(34):16536-45.
1987: James Gulick; K Kropp; Jeffrey Robbins
The developmentally regulated expression of two linked myosin heavy-chain genes.
European journal of biochemistry / FEBS 1987;169(1):79-84.
1987: M I Molina; K E Kropp; James Gulick; Jeffrey Robbins
The sequence of an embryonic myosin heavy chain gene and isolation of its corresponding cDNA.
The Journal of biological chemistry 1987;262(14):6478-88.
1986: K Kropp; James Gulick; Jeffrey Robbins
A canonical sequence organization at the 5'-end of the myosin heavy chain genes.
The Journal of biological chemistry 1986;261(14):6613-8.
1986: Jeffrey Robbins; T Horan; James Gulick; K Kropp
The chicken myosin heavy chain family.
The Journal of biological chemistry 1986;261(14):6606-12.
1985: James Gulick; K Kropp; Jeffrey Robbins
The structure of two fast-white myosin heavy chain promoters. A comparative study.
The Journal of biological chemistry 1985;260(27):14513-20.