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Paul Robbins

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TOP 3
Nam Vo; Lloydine Jacobs; James Kang; Luigi Aurelio Nasto; Laura J Niedernhofer; Paul D Robbins; Christopher H Evans
An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints.
Qian Chen; Cheryl L Clauson; Kai Liu; Laura J Niedernhofer; Paul D Robbins; Andria R Robinson; Harry C Blair; Hongjiao Ouyang
DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism.
Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Arthritis gene therapy and its tortuous path into the clinic.

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All Publications

2013: Nam Vo; Lloydine Jacobs; James Kang; Luigi Aurelio Nasto; Laura J Niedernhofer; Paul D Robbins; Christopher H Evans
An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013;31(6):831-7.
2013: Qian Chen; Cheryl L Clauson; Kai Liu; Laura J Niedernhofer; Paul D Robbins; Andria R Robinson; Harry C Blair; Hongjiao Ouyang
DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(5):1214-28.
2013: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Arthritis gene therapy and its tortuous path into the clinic.
Translational research : the journal of laboratory and clinical medicine 2013;161(4):205-16.
2013: Mitra Lavasani; Aiping Lu; Paul D Robbins; Seth D Thompson; Johnny Huard; Laura J Niedernhofer
Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces.
Methods in molecular biology (Clifton, N.J.) 2013;976():53-65.
2013: Luigi A Nasto; Kevin Ngo; Laura J Niedernhofer; Enrico Pola; Paul D Robbins; Andria R Robinson; Peter Roughley; Gwendolyn Sowa; Cheryl L Clauson; Qing Dong; Michael Epperly; Saiful M Huq; James Kang; Dong Wang; Nam V Vo
Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs.
Mechanisms of ageing and development 2013;134(1-2):35-42.
2012: Luigi A Nasto; Kevin Ngo; Laura J Niedernhofer; Enrico Pola; Paul D Robbins; Andria R Robinson; Hyoung Yeon Seo; Gwendolyn A Sowa; Jeremy S Tilstra; Cheryl L Clauson; Qing Dong; James D Kang; Joon Y Lee; Nam V Vo
ISSLS prize winner: inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging.
Spine 2012;37(21):1819-25.
2012: Jin Wang; Cheryl L Clauson; Laura J Niedernhofer; Paul D Robbins; Yinsheng Wang
The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner.
Aging cell 2012;11(4):714-6.
2012: D F Gaddy; T J Kieffer; M J Riedel; Suzanne Bertera; Paul D Robbins
dsAAV8-mediated gene transfer and β-cell expression of IL-4 and β-cell growth factors are capable of reversing early-onset diabetes in NOD mice.
Gene therapy 2012;19(8):791-9.
2012: Jeremy S Tilstra; Arvydas Usas; Nam Vo; Jin Wang; Yinsheng Wang; Simon C Watkins; Andria R Robinson; Claudette M St Croix; Donna B Stolz; Cheryl L Clauson; Paula R Clemens; George A Garinis; Siobhán Q Gregg; Denis C Guttridge; Johnny Huard; Luigi A Nasto; Laura J Niedernhofer; Daniel P Reay; Paul D Robbins
NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
The Journal of clinical investigation 2012;122(7):2601-12.
2012: Chenjie Yang; Melanie A Ruffner; Seon-Hee Kim; Paul D Robbins
Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses.
European journal of immunology 2012;42(7):1778-84.
2012: Aiping Lu; Laura J Niedernhofer; Jonathan D Proto; Paul D Robbins; Ying Tang; Jeremy S Tilstra; Bing Wang; Lulin Guo; Denis C Guttridge; Mitra Lavasani; Johnny Huard
NF-κB negatively impacts the myogenic potential of muscle-derived stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(3):661-8.
2012: J Reay; A Gambotto; Paul D Robbins
The antitumor effects of adenoviral-mediated, intratumoral delivery of interleukin 23 require endogenous IL-12.
Cancer gene therapy 2012;19(2):135-43.
2012: Chenjie Yang; Geetha Chalasani; Yue-Harn Ng; Paul D Robbins
Exosomes released from Mycoplasma infected tumor cells activate inhibitory B cells.
PloS one 2012;7(4):e36138.
2012: Chenjie Yang; Paul D Robbins
Immunosuppressive exosomes: a new approach for treating arthritis.
International journal of rheumatology 2012;2012():573528.
2011: Jeremy S Tilstra; Cheryl L Clauson; Laura J Niedernhofer; Paul D Robbins
NF-κB in Aging and Disease.
Aging and disease 2011;2(6):449-65.
2011: Daniel P Reay; Khaleel K Rehman; Paul D Robbins; Jon F Watchko; Michele Yang; Monica J Daood; Denis C Guttridge; Terrence L O'Day; Paula R Clemens
Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology.
Neurobiology of disease 2011;43(3):598-608.
2011: James R Goss; Norma Arbujas; Joseph C Glorioso; Paul D Robbins; Andria Rasile Robinson; Donna Beer Stolz; Mingdi Zhang; Laura J Niedernhofer
Premature aging-related peripheral neuropathy in a mouse model of progeria.
Mechanisms of ageing and development 2011;132(8-9):437-42.
2011: Chenjie Yang; Nicole R Bianco; Seon-Hee Kim; Paul D Robbins
Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model.
PloS one 2011;6(8):e22517.
2011: Laura J Niedernhofer; Joseph C Glorioso; Paul D Robbins
Dedifferentiation rescues senescence of progeria cells but only while pluripotent.
Stem cell research & therapy 2011;2(3):28.
2011: Maliha Zahid; Paul D Robbins
Identification and characterization of tissue-specific protein transduction domains using peptide phage display.
Methods in molecular biology (Clifton, N.J.) 2011;683():277-89.
2010: Nam Vo; Hyoung Yeon Seo; Andria Robinson; Gwendolyn Sowa; Douglas Bentley; Lauren Taylor; Rebecca K Studer; Arvydas Usas; Johnny Huard; Sean Alber; simon simon watkins; Joon Lee; Paulo Coehlo; Dong Wang; Mattia Loppini; Paul D Robbins; Laura J Niedernhofer; James Kang
Accelerated aging of intervertebral discs in a mouse model of progeria.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2010;28(12):1600-7.
2010: Y Tang; Paula R Clemens; D C Guttridge; Johnny Huard; M Y Mi; Daniel P Reay; Paul D Robbins; M N Salay; Bing Wang
Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice.
Gene therapy 2010;17(12):1476-83.
2010: Maliha Zahid; Brett E Phillips; Sean M Albers; Nick Giannoukakis; simon simon watkins; Paul D Robbins
Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice.
PloS one 2010;5(8):e12252.
2010: Melanie A Ruffner; Paul D Robbins
Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice.
PloS one 2010;5(7):e11848.
2010: Hiyaa Singhee Ghosh; Michael McBurney; Paul D Robbins
SIRT1 negatively regulates the mammalian target of rapamycin.
PloS one 2010;5(2):e9199.
2009: Melanie A Ruffner; Seon Hee Kim; Nicole R Bianco; Loise M Francisco; Arlene H Sharpe; Paul D Robbins
B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function.
European journal of immunology 2009;39(11):3084-90.
2009: J Reay; Su-Hyeong Kim; E Lockhart; Jay K Kolls; Paul D Robbins
Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response.
Cancer gene therapy 2009;16(10):776-85.
2009: Jesse D Kay; Elvire Gouze; Thomas J Oligino; Jean-Noel Gouze; Rachael S Watson; Padraic P Levings; Marsha L Bush; Anthony Dacanay; David M Nickerson; Paul D Robbins; Christopher H Evans; Steven C Ghivizzani
Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus.
The journal of gene medicine 2009;11(7):605-14.
2009: Nicole R Bianco; Seon Hee Kim; Melanie A Ruffner; Paul D Robbins
Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models.
Arthritis and rheumatism 2009;60(2):380-9.
2009: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Orthopedic gene therapy in 2008.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(2):231-44.
2009: Peter Wehling; Julio A Reinecke; Axel W A Baltzer; M Granrath; KP Schulitz; Carl Schultz; Rüdiger Krauspe; Theresa W Whiteside; Elaine Elder; Steven C Ghivizzani; Paul D Robbins; Christopher H Evans
Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis.
Human gene therapy 2009;20(2):97-101.
2009: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Gene therapy of the rheumatic diseases: 1998 to 2008.
Arthritis research & therapy 2009;11(1):209.
2008: Qin Yang; Stine K Larsen; Zhibao Mi; Paul D Robbins; Per H Basse
PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymes.
The AAPS journal 2008;10(4):614-21.
2008: A W Thomson; Paul D Robbins
Tolerogenic dendritic cells for autoimmune disease and transplantation.
Annals of the rheumatic diseases 2008;67 Suppl 3():iii90-6.
2008: Fei Sun; Zhibao Mi; Steven B Condliffe; Carol A Bertrand; Xiaoyan Gong; Xiaoli Lu; Ruilin Zhang; Joseph Latoche; Joseph M Pilewski; Paul D Robbins; Raymond A Frizzell
Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(9):3255-63.
2008: Steven C Ghivizzani; Elvire Gouze; Jean-Noel Gouze; Jesse D Kay; Marsha L Bush; Rachael S Watson; Padraic P Levings; David M Nickerson; Patrick T Colahan; Paul D Robbins; Christopher H Evans
Perspectives on the use of gene therapy for chronic joint diseases.
Current gene therapy 2008;8(4):273-86.
2008: Khaja K Rehman; Massimo Trucco; Zhong Wang; Xiao Xiao; Paul D Robbins
AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(8):1409-16.
2008: Eric A Levicoff; Joseph S Kim; Satoshi Sobajima; Corey J Wallach; James W Larson; Paul D Robbins; Xiao Xiao; Li Juan; Gianluca Vadalà; Lars G Gilbertson; James D Kang
Safety assessment of intradiscal gene therapy II: effect of dosing and vector choice.
Spine 2008;33(14):1509-16; discussion 1517.
2008: Angela Montecalvo; William J Shufesky; Donna B Stolz; Mara G Sullivan; Zhiliang Wang; Sherrie J Divito; Glenn D Papworth; simon simon watkins; Paul D Robbins; Adriana T Larregina; Adrian E Morelli
Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3081-90.
2008: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Arthritis gene therapy's first death.
Arthritis research & therapy 2008;10(3):110.
2008: Laura J Niedernhofer; Paul D Robbins
Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan.
The international journal of biochemistry & cell biology 2008;40(2):176-80.
2007: Shaival H Davé; Jeremy S Tilstra; Katsuyoshi Matsuoka; Fengling Li; Thomas Karrasch; Jennifer K Uno; Antonia R Sepulveda; Christian Jobin; Albert S Baldwin; Paul D Robbins; Scott Plevy
Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7852-9.
2007: Hiyaa S Ghosh; James V Spencer; Bobby Ng; Michael W McBurney; Paul D Robbins
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription.
The Biochemical journal 2007;408(1):105-11.
2007: Alan J Nixon; Laurie R Goodrich; Michael S Scimeca; Thomas H Witte; Lauren V Schnabel; Ashlee E Watts; Paul D Robbins
Gene therapy in musculoskeletal repair.
Annals of the New York Academy of Sciences 2007;1117():310-27.
2007: Sophie Morisset; David D Frisbie; Paul D Robbins; Alan J Nixon; Wayne McIlwraith
IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects.
Clinical orthopaedics and related research 2007;462():221-8.
2007: Khaja K Rehman; Suzanne Bertera; Massimo Trucco; Andrea Gambotto; Paul D Robbins
Immunomodulation by adenoviral-mediated SCD40-Ig gene therapy for mouse allogeneic islet transplantation.
Transplantation 2007;84(3):301-7.
2007: Seon Hee Kim; Nicole R Bianco; William J Shufesky; Adrian E Morelli; Paul D Robbins
Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2242-9.
2007: Seon Hee Kim; Nicole R Bianco; William J Shufesky; Adrian E Morelli; Paul D Robbins
MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2235-41.
2007: Jeremy S Tilstra; Khaja K Rehman; T Hennon; Scott Plevy; Paula R Clemens; Paul D Robbins
Protein transduction: identification, characterization and optimization.
Biochemical Society transactions 2007;35(Pt 4):811-5.
2007: Laurie R Goodrich; Chisa Hidaka; Paul D Robbins; C H Evans; Alan J Nixon
Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model.
The Journal of bone and joint surgery. British volume 2007;89(5):672-85.
2007: Stephen R Goding; Qin Yang; Z Mi; Paul D Robbins; Per H Basse
Targeting of products of genes to tumor sites using adoptively transferred A-NK and T-LAK cells.
Cancer gene therapy 2007;14(5):441-50.
2007: Nicole R Bianco; Seon-Hee Kim; Adrian E Morelli; Paul D Robbins
Modulation of the immune response using dendritic cell-derived exosomes.
Methods in molecular biology (Clifton, N.J.) 2007;380():443-55.
2006: Annahita Keravala; Dexi Liu; Eric R Lechman; Darren Wolfe; Joan A Nash; David J Lampe; Paul D Robbins
Hyperactive Himar1 transposase mediates transposition in cell culture and enhances gene expression in vivo.
Human gene therapy 2006;17(10):1006-18.
2006: Laurie R Goodrich; Brent Brower-Toland; Lorin D Warnick; Paul D Robbins; Chris H Evans; Alan J Nixon
Direct adenovirus-mediated IGF-I gene transduction of synovium induces persisting synovial fluid IGF-I ligand elevations.
Gene therapy 2006;13(17):1253-62.
2006: Annahita Keravala; Joylette L Portlock; Joan A Nash; David Vitrant; Paul D Robbins; Michele P Calos
PhiC31 integrase mediates integration in cultured synovial cells and enhances gene expression in rabbit joints.
The journal of gene medicine 2006;8(8):1008-17.
2006: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Will arthritis gene therapy become a clinical reality?
Nature clinical practice. Rheumatology 2006;2(7):344-5.
2006: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Gene therapy for arthritis: what next?
Arthritis and rheumatism 2006;54(6):1714-29.
2006: Christopher H Evans; Elvire Gouze; Jean-Noel Gouze; Paul D Robbins; Steven C Ghivizzani
Gene therapeutic approaches-transfer in vivo.
Advanced drug delivery reviews 2006;58(2):243-58.
2006: M Egermann; AW Baltzer; S Adamaszek; C Evans; Paul D Robbins; E Schneider; CA Lill
Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep.
Human gene therapy 2006;17(5):507-17.
2006: Zhong Wang; Tong Zhu; Khaja K Rehman; Suzanne Bertera; Jian Zhang; Chunlian Chen; Glenn D Papworth; simon simon watkins; Massimo Trucco; Paul D Robbins; J Li; Xiao Xiao
Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes.
Diabetes 2006;55(4):875-84.
2006: Corey J Wallach; Joseph S Kim; Satoshi Sobajima; christian lattermann; William M Oxner; Kathryn McFadden; Paul D Robbins; Lars G Gilbertson; James D Kang
Safety assessment of intradiscal gene transfer: a pilot study.
The spine journal : official journal of the North American Spine Society 2006;6(2):107-12.
2006: Wentao Gao; Adam C Soloff; Xiuhua Lu; Angela Montecalvo; Doan C Nguyen; Yumi Matsuoka; Paul D Robbins; David E Swayne; Ruben O Donis; Jacqueline M Katz; Simon M Barratt-Boyes; Andrea Gambotto
Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization.
Journal of virology 2006;80(4):1959-64.
2006: Zoya R Yurkovetsky; Galina V Shurin; Denise A Barry; Andre C Schuh; Michael R Shurin; Paul D Robbins
Comparative analysis of antitumor activity of CD40L, RANKL, and 4-1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells.
The journal of gene medicine 2006;8(2):129-37.
2006: Seon Hee Kim; Nicole R Bianco; Rajasree Menon; Eric R Lechman; William J Shufesky; Adrian E Morelli; Paul D Robbins
Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(2):289-300.
2006: Annahita Keravala; Eric R Lechman; Joan Nash; Zhibao Mi; Paul D Robbins
Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis.
Arthritis research & therapy 2006;8(4):R91.
2006: Qingping Yao; Dai-Wu Seol; Zhibao Mi; Paul D Robbins
Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis.
Arthritis research & therapy 2006;8(1):R16.
2006: Simon M Barratt-Boyes; Adam C Soloff; Wentao Gao; Edward Nwanegbo; Xiangdong Liu; Premeela A Rajakumar; Kevin N Brown; Paul D Robbins; Michael Murphey-Corb; Richard D Day; Andrea Gambotto
Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5- and 35-based vectors.
The Journal of general virology 2006;87(Pt 1):139-49.
2005: P Mukherjee; Shang-You Yang; Bin Wu; Zheng Song; Linda K Myers; Paul D Robbins; Paul H Wooley
Tumour necrosis factor receptor gene therapy affects cellular immune responses in collagen induced arthritis in mice.
Annals of the rheumatic diseases 2005;64(11):1550-6.
2005: Khaja K Rehman; Zhiliang Wang; Rita Bottino; AN Balamurugan; Massimo Trucco; J Li; Xiao Xiao; Paul D Robbins
Efficient gene delivery to human and rodent islets with double-stranded (ds) AAV-based vectors.
Gene therapy 2005;12(17):1313-23.
2005: Koichiro Kawamura; Constance R Chu; Satoshi Sobajima; Paul D Robbins; Freddie H Fu; Nicholas J Izzo; Christopher Niyibizi
Adenoviral-mediated transfer of TGF-beta1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures.
Experimental hematology 2005;33(8):865-72.
2005: Christopher H Evans; Steven C Ghivizzani; James H Herndon; Paul D Robbins
Gene therapy for the treatment of musculoskeletal diseases.
The Journal of the American Academy of Orthopaedic Surgeons 2005;13(4):230-42.
2005: Christopher H Evans; Paul D Robbins; Steven C Ghivizzani; Mary Chester Wasko; Matthew M Tomaino; Richard Kang; Thomas A Muzzonigro; Molly Vogt; Elaine Elder; Theresa L Whiteside; simon simon watkins; James H Herndon
Gene transfer to human joints: progress toward a gene therapy of arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(24):8698-703.
2005: Seon-Hee Kim; Eric R Lechman; Nicole R Bianco; Rajasree Menon; Annahita Keravala; Joan Nash; Zhibao Mi; simon simon watkins; Andrea Gambotto; Paul D Robbins
Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6440-8.
2005: Shang-You Yang; Sam Nasser; David C Markel; Paul D Robbins; Paul H Wooley
Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor.
The Journal of bone and joint surgery. American volume 2005;87(5):1088-97.
2005: christian lattermann; William M Oxner; Xiao Xiao; J Li; Lars G Gilbertson; Paul D Robbins; James D Kang
The adeno associated viral vector as a strategy for intradiscal gene transfer in immune competent and pre-exposed rabbits.
Spine 2005;30(5):497-504.
2005: Raja Mahidhara; Pierre Queiroz de Oliveira; Jaromir Kohout; David G Beer; Jiayuh Lin; simon simon watkins; Paul D Robbins; Steven J Hughes
Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma.
The Journal of surgical research 2005;123(2):302-11.
2005: Christopher H Evans; Steven C Ghivizzani; Elvire Gouze; John J Rediske; Edward M Schwarz; Paul D Robbins
The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics.
Arthritis research & therapy 2005;7(6):273-8.
2005: Jennifer L Haupt; David D Frisbie; Wayne McIlwraith; Paul D Robbins; Steven C Ghivizzani; Chris H Evans; Alan J Nixon
Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005;23(1):118-26.
2005: Alan J Nixon; Jennifer L Haupt; David D Frisbie; Sophie Morisset; Wayne McIlwraith; Paul D Robbins; Chris H Evans; Steven C Ghivizzani
Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy.
Gene therapy 2005;12(2):177-86.
2004: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
The 2003 Nicolas Andry Award. Orthopaedic gene therapy.
Clinical orthopaedics and related research 2004;(429):316-29.
2004: Jennifer Machen; Suzanne Bertera; Y Chang; Rita Bottino; AN Balamurugan; Paul D Robbins; Massimo Trucco; Nick Giannoukakis
Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-Ig fusion decoy.
Gene therapy 2004;11(20):1506-14.
2004: christian lattermann; Boris A Zelle; Janey D Whalen; Axel W A Baltzer; Paul D Robbins; Christopher Niyibizi; Christopher H Evans; Freddie H Fu
Gene transfer to the tendon-bone insertion site.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 2004;12(5):510-5.
2004: christian lattermann; Axel W A Baltzer; Boris A Zelle; Janey D Whalen; Christopher Niyibizi; Paul D Robbins; Christopher H Evans; Gary S Gruen
Feasibility of percutaneous gene transfer to an atrophic nonunion in a rabbit.
Clinical orthopaedics and related research 2004;(425):237-43.
2004: Suzanne Bertera; Angela M Alexander; Megan L Crawford; Glenn D Papworth; simon simon watkins; Paul D Robbins; Massimo Trucco
Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans.
Experimental diabesity research 2004;5(3):201-10.
2004: Christopher Niyibizi; Sujing Wang; Zhibao Mi; Paul D Robbins
The fate of mesenchymal stem cells transplanted into immunocompetent neonatal mice: implications for skeletal gene therapy via stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(6):955-63.
2004: Levent Balkir; Irina L Tourkova; Valeria P Makarenkova; Galina V Shurin; Paul D Robbins; Xiao-Ming Yin; Gurkamal S Chatta; Michael R Shurin
Comparative analysis of dendritic cells transduced with different anti-apoptotic molecules: sensitivity to tumor-induced apoptosis.
The journal of gene medicine 2004;6(5):537-44.
2004: Hongmei Shen; Jeffrey C Mai; Lu Qiu; Shaonan Cao; Paul D Robbins; Tao Cheng
Evaluation of peptide-mediated transduction in human CD34+ cells.
Human gene therapy 2004;15(4):415-9.
2004: Enrico Pola; Wentao Gao; Y Zhou; Roberto Pola; W Lattanzi; Charles Sfeir; Andrea Gambotto; Paul D Robbins
Efficient bone formation by gene transfer of human LIM mineralization protein-3.
Gene therapy 2004;11(8):683-93.
2004: Wentao Gao; Alexis Rzewski; Huijie Sun; Paul D Robbins; Andrea Gambotto
UpGene: Application of a web-based DNA codon optimization algorithm.
Biotechnology progress 2004;20(2):443-8.
2004: Edward Nwanegbo; Eftyhia Vardas; Wentao Gao; Hilton Whittle; Huijie Sun; David Rowe; Paul D Robbins; Andrea Gambotto
Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of The Gambia, South Africa, and the United States.
Clinical and diagnostic laboratory immunology 2004;11(2):351-7.
2004: Shang-You Yang; Bin Wu; Lois Mayton; P Mukherjee; Paul D Robbins; C H Evans; Paul H Wooley
Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis.
Gene therapy 2004;11(5):483-91.
2004: Christopher H Evans; Jean-Noel Gouze; Elvire Gouze; Paul D Robbins; Steven C Ghivizzani
Osteoarthritis gene therapy.
Gene therapy 2004;11(4):379-89.
2004: Christopher Niyibizi; S Wang; Zhibao Mi; Paul D Robbins
Gene therapy approaches for osteogenesis imperfecta.
Gene therapy 2004;11(4):408-16.
2004: Arnulf Pascher; Glyn D Palmer; Andre Steinert; Thomas J Oligino; Elvire Gouze; Jean-Noel Gouze; Oliver Betz; Myron Spector; Paul D Robbins; Christopher H Evans; Steven C Ghivizzani
Gene delivery to cartilage defects using coagulated bone marrow aspirate.
Gene therapy 2004;11(2):133-41.
2003: Wentao Gao; Azaibi Tamin; Adam C Soloff; Leonardo D'Aiuto; Edward Nwanegbo; Paul D Robbins; William Joseph Bellini; Simon M Barratt-Boyes; Andrea Gambotto
Effects of a SARS-associated coronavirus vaccine in monkeys.
Lancet 2003;362(9399):1895-6.
2003: Toru Kitagawa; Takashi Iwazawa; Paul D Robbins; Michael T Lotze; Hideaki Tahara
Advantages and limitations of particle-mediated transfection (gene gun) in cancer immuno-gene therapy using IL-10, IL-12 or B7-1 in murine tumor models.
The journal of gene medicine 2003;5(11):958-65.
2003: Eric R Lechman; Annahita Keravala; Joan Nash; Seon Hee Kim; Zhibao Mi; Paul D Robbins
The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen.
Gene therapy 2003;10(24):2029-35.
2003: Wentao Gao; Paul D Robbins; Andrea Gambotto
Human adenovirus type 35: nucleotide sequence and vector development.
Gene therapy 2003;10(23):1941-9.
2003: Jianfei Jiang; Behice F Serinkan; Yulia Y Tyurina; Grigory G Borisenko; Zhibao Mi; Paul D Robbins; Alan J Schroit; Valerian E Kagan
Peroxidation and externalization of phosphatidylserine associated with release of cytochrome c from mitochondria.
Free radical biology & medicine 2003;35(7):814-25.
2003: Tomohide Tatsumi; Jian Huang; William Gooding; Andrea Gambotto; Paul D Robbins; Nikola L Vujanovic; Sean Alber; simon simon watkins; Hideho Okada; Walter J Storkus
Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity.
Cancer research 2003;63(19):6378-86.
2003: M R Hitchens; Paul D Robbins
The role of the transcription factor DP in apoptosis.
Apoptosis : an international journal on programmed cell death 2003;8(5):461-8.
2003: Timothy F Witham; Lorissa Villa; Tianbing Yang; Ian F Pollack; Hideho Okada; Paul D Robbins; William Chambers
Expression of a soluble transforming growth factor-beta (TGFbeta) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivo.
Journal of neuro-oncology 2003;64(1-2):63-9.
2003: Zhibao Mi; Xiaoli Lu; Jeffrey C Mai; Bobby G Ng; Guiqiang Wang; Eric R Lechman; simon simon watkins; Hannah Rabinowich; Paul D Robbins
Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(2):295-305.
2003: Linlin Ma; Shiguang Qian; Xiaoyan Liang; Lianfu Wang; Jennifer E Woodward; Nick Giannoukakis; Paul D Robbins; Suzanne Bertera; Massimo Trucco; John J Fung; Lina Lu
Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity.
Diabetes 2003;52(8):1976-85.
2003: P Mukherjee; Bin Wu; Lois Mayton; S-H Kim; Paul D Robbins; Paul H Wooley
TNF receptor gene therapy results in suppression of IgG2a anticollagen antibody in collagen induced arthritis.
Annals of the rheumatic diseases 2003;62(8):707-14.
2003: Q Yao; S Wang; Andrea Gambotto; Joseph C Glorioso; Christopher H Evans; Paul D Robbins; Steven C Ghivizzani; Thomas J Oligino
Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium.
Gene therapy 2003;10(12):1055-60.
2003: Paul D Robbins; Christopher H Evans; Y Chernajovsky
Gene therapy for arthritis.
Gene therapy 2003;10(10):902-11.
2003: Claus J Gruss; Kapaettu Satyamoorthy; Carola Berking; John Lininger; Mark Nesbit; Helmut Schaider; Zhao-Jun Liu; Masahiro Oka; Mei-Yu Hsu; Takashi Shirakawa; Gang Li; Thomas Bogenrieder; Peter Carmeliet; Wafik S El-Deiry; Stephen L Eck; Justi S Rao; Andrew H Baker; Jean T Bennet; Timothy M Crombleholme; Omaida Velazquez; Jagajan Karmacharya; David J Margolis; James M Wilson; Michael Detmar; Mihaela Skobe; Paul D Robbins; Clayton Buck; Meenhard Herlyn
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice.
The Journal of investigative dermatology 2003;120(4):683-92.
2003: Paul L Leong; Genevieve A Andrews; Daniel E Johnson; Kevin F Dyer; Sichuan Xi; Jeffrey C Mai; Paul D Robbins; Seshu Gadiparthi; Nancy A Burke; simon simon watkins; Jennifer Rubin Grandis
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4138-43.
2003: Muneo Numasaki; Jun-ichi Fukushi; Mayumi Ono; Satwant K Narula; Paul J Zavodny; Toshio Kudo; Paul D Robbins; Hideaki Tahara; Michael T Lotze
Interleukin-17 promotes angiogenesis and tumor growth.
Blood 2003;101(7):2620-7.
2003: Khaja K Rehman; Suzanne Bertera; Rita Bottino; AN Balamurugan; Jeffrey C Mai; Zhibao Mi; Massimo Trucco; Paul D Robbins
Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide.
The Journal of biological chemistry 2003;278(11):9862-8.
2003: Xuehui Geng; Lehong Li; simon simon watkins; Paul D Robbins; Peter Drain
The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas.
Diabetes 2003;52(3):767-76.
2003: Wataru Hashimoto; Fumiaki Tanaka; Paul D Robbins; Masaru Taniguchi; Haruki Okamura; Michael T Lotze; Hideaki Tahara
Natural killer, but not natural killer T, cells play a necessary role in the promotion of an innate antitumor response induced by IL-18.
International journal of cancer. Journal international du cancer 2003;103(4):508-13.
2003: Suzanne Bertera; Megan L Crawford; Angela M Alexander; Glenn D Papworth; simon simon watkins; Paul D Robbins; Massimo Trucco
Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes.
Diabetes 2003;52(2):387-93.
2003: Zhibao Mi; Steven C Ghivizzani; Eric R Lechman; Joseph C Glorioso; Christopher H Evans; Paul D Robbins
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees.
Arthritis research & therapy 2003;5(3):R132-9.
2003: Maryam Feili-Hariri; Dewayne H Falkner; Andrea Gambotto; Glenn D Papworth; simon simon watkins; Paul D Robbins; Penelope A Morel
Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis.
Human gene therapy 2003;14(1):13-23.
2003: Katsuhiko Kaneko; Zhiliang Wang; Seon Hee Kim; Adrian E Morelli; Paul D Robbins; Angus W Thomson
Dendritic cells genetically engineered to express IL-4 exhibit enhanced IL-12p70 production in response to CD40 ligation and accelerate organ allograft rejection.
Gene therapy 2003;10(2):143-52.
2003: Wentao Gao; Sanjay Kumar; Michael T Lotze; Charles Hanning; Paul D Robbins; Andrea Gambotto
Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):107-13.
2002: Yuji Satoh; Clemens Esche; Andrea Gambotto; Galina V Shurin; Zoya R Yurkovetsky; Paul D Robbins; simon simon watkins; Satoru Todo; Ronald Herberman; Michael T Lotze; Michael R Shurin
Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice.
Journal of experimental therapeutics & oncology 2002;2(6):337-49.
2002: Irina L Tourkova; Zoya R Yurkovetsky; Andrea Gambotto; Valeria P Makarenkova; Lori Perez; Levent Balkir; Paul D Robbins; Michael R Shurin; Galina V Shurin
Increased function and survival of IL-15-transduced human dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2.
Journal of leukocyte biology 2002;72(5):1037-45.
2002: Seon Hee Kim; Eric R Lechman; Sunyoung Kim; Joan Nash; Thomas J Oligino; Paul D Robbins
Ex vivo gene delivery of IL-1Ra and soluble TNF receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):591-600.
2002: Seon Hee Kim; Sunyoung Kim; Thomas J Oligino; Paul D Robbins
Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):584-90.
2002: Fumiaki Tanaka; Wataru Hashimoto; Paul D Robbins; Michael T Lotze; Hideaki Tahara
Therapeutic and specific antitumor immunity induced by co-administration of immature dendritic cells and adenoviral vector expressing biologically active IL-18.
Gene therapy 2002;9(21):1480-6.
2002: Linlin Ma; William A Rudert; Jo Harnaha; Marietta Wright; Jennifer Machen; Robert Lakomy; Shiguang Qian; Lina Lu; Paul D Robbins; Massimo Trucco; Nick Giannoukakis
Immunosuppressive effects of glucosamine.
The Journal of biological chemistry 2002;277(42):39343-9.
2002: Tomohide Tatsumi; Andrea Gambotto; Paul D Robbins; Walter J Storkus
Interleukin 18 gene transfer expands the repertoire of antitumor Th1-type immunity elicited by dendritic cell-based vaccines in association with enhanced therapeutic efficacy.
Cancer research 2002;62(20):5853-8.
2002: C Andrew Bonham; Lansha Peng; Xiaoyan Liang; Zongyou Chen; Lianfu Wang; Linlin Ma; Holger Hackstein; Paul D Robbins; Angus W Thomson; John J Fung; Shiguang Qian; Lina Lu
Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3382-91.
2002: Massimo Trucco; Paul D Robbins; Angus W Thomson; Nick Giannoukakis
Gene therapy strategies to prevent autoimmune disorders.
Current gene therapy 2002;2(3):341-54.
2002: Jeffrey C Mai; Hongmei Shen; simon simon watkins; Tao Cheng; Paul D Robbins
Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate.
The Journal of biological chemistry 2002;277(33):30208-18.
2002: Shang-You Yang; Bin Wu; Lois Mayton; C H Evans; Paul D Robbins; Paul H Wooley
IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(7):342-50.
2002: simon simon watkins; Xuehui Geng; Lehong Li; Glenn D Papworth; Paul D Robbins; Peter Drain
Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide.
Traffic (Copenhagen, Denmark) 2002;3(7):461-71.
2002: Zheng Ma; Zhibao Mi; Annette Wilson; Sean Alber; Paul D Robbins; simon simon watkins; Bruce R Pitt; Song Li
Redirecting adenovirus to pulmonary endothelium by cationic liposomes.
Gene therapy 2002;9(3):176-82.
2002: Angela M Alexander; Megan Crawford; Suzanne Bertera; William A Rudert; Osamu Takikawa; Paul D Robbins; Massimo Trucco
Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes.
Diabetes 2002;51(2):356-65.
2002: Glyn Palmer; Arnulf Pascher; Elvire Gouze; Jean-Noel Gouze; Oliver Betz; Myron Spector; Paul D Robbins; Christopher H Evans; Steven C Ghivizzani
Development of gene-based therapies for cartilage repair.
Critical reviews in eukaryotic gene expression 2002;12(4):259-73.
2002: Christopher Niyibizi; Corey J Wallach; Zhibao Mi; Paul D Robbins
Approaches for skeletal gene therapy.
Critical reviews in eukaryotic gene expression 2002;12(3):163-73.
2002: Nick Giannoukakis; Paul D Robbins
Gene and cell therapies for diabetes mellitus: strategies and clinical potential.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2002;16(3):149-73.
2002: David D Frisbie; Steven C Ghivizzani; Paul D Robbins; C H Evans; Wayne McIlwraith
Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene.
Gene therapy 2002;9(1):12-20.
2001: Jean-Noel Gouze; Steven C Ghivizzani; Elvire Gouze; Glyn D Palmer; Oliver Betz; Paul D Robbins; Christopher H Evans; James H Herndon
Gene therapy for rheumatoid arthritis.
Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 2001;6(2):211-9.
2001: Sudha Sud; Shang-You Yang; C H Evans; Paul D Robbins; Paul H Wooley
Effects of cytokine gene therapy on particulate-induced inflammation in the murine air pouch.
Inflammation 2001;25(6):361-72.
2001: Axel W A Baltzer; Janey D Whalen; Paul H Wooley; C Latterman; L M Truchan; Paul D Robbins; Christopher H Evans
Gene therapy for osteoporosis: evaluation in a murine ovariectomy model.
Gene therapy 2001;8(23):1770-6.
2001: J D Whalen; Angus W Thomson; Lina Lu; Paul D Robbins; Christopher H Evans
Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: evidence for involvement of genetically modified dendritic cells and macrophages.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(6):543-50.
2001: Yun You Li; Z Mi; Y Feng; Charles F McTiernan; Renping Zhou; Paul D Robbins; simon simon watkins; Arthur M Feldman
Differential effects of overexpression of two forms of ephrin-A5 on neonatal rat cardiomyocytes.
American journal of physiology. Heart and circulatory physiology 2001;281(6):H2738-46.
2001: Elvire Gouze; Steven C Ghivizzani; Glyn D Palmer; Jean-Noel Gouze; Paul D Robbins; Christopher H Evans
Gene therapy for rheumatoid arthritis.
Expert opinion on biological therapy 2001;1(6):971-8.
2001: Jeffrey C Mai; Zhibao Mi; S H Kim; B Ng; Paul D Robbins
A proapoptotic peptide for the treatment of solid tumors.
Cancer research 2001;61(21):7709-12.
2001: RA Saxer; Stephen J Bent; Brent Brower-Toland; Z Mi; Paul D Robbins; Chris H Evans; Alan J Nixon
Gene mediated insulin-like growth factor-I delivery to the synovium.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(5):759-67.
2001: Chunxia Lu; G Schwartzbauer; Mark A Sperling; Sherin U Devaskar; Shanthie Thamotharan; Paul D Robbins; C F McTiernan; J L Liu; Jianfei Jiang; Stuart J Frank; Ramkumar Menon
Demonstration of direct effects of growth hormone on neonatal cardiomyocytes.
The Journal of biological chemistry 2001;276(25):22892-900.
2001: Q Yao; Shaomeng Wang; Joseph C Glorioso; Christopher H Evans; Paul D Robbins; Steven C Ghivizzani; Thomas J Oligino
Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(6):901-10.
2001: Douglas S Musgrave; Ryan Pruchnic; V Wright; Patrick P Bosch; Steven C Ghivizzani; Paul D Robbins; Johnny Huard
The effect of bone morphogenetic protein-2 expression on the early fate of skeletal muscle-derived cells.
Bone 2001;28(5):499-506.
2001: Toshiaki Kadokami; Charles F McTiernan; Toru Kubota; Carole S Frye; GS Bounoutas; Paul D Robbins; simon simon watkins; Arthur M Feldman
Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expression.
American journal of physiology. Heart and circulatory physiology 2001;280(5):H2281-91.
2001: Seon Hee Kim; S Kim; Christopher H Evans; Steven C Ghivizzani; Thomas J Oligino; Paul D Robbins
Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3499-505.
2001: Elvire Gouze; Steven C Ghivizzani; Paul D Robbins; Christopher H Evans
Gene therapy for rheumatoid arthritis.
Current rheumatology reports 2001;3(1):79-85.
2001: Brent Brower-Toland; RA Saxer; Laurie R Goodrich; Z Mi; Paul D Robbins; Chris H Evans; Alan J Nixon
Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function.
Human gene therapy 2001;12(2):117-29.
2001: M A Del Vecchio; Helga I Georgescu; JE McCormack; Paul D Robbins; Christopher H Evans
Approaches to enhancing the retroviral transduction of human synoviocytes.
Arthritis research 2001;3(4):259-63.
2001: Christopher H Evans; Steven C Ghivizzani; T A Oligino; Paul D Robbins
Future of adenoviruses in the gene therapy of arthritis.
Arthritis research 2001;3(3):142-6.
2001: Takashi Iwazawa; G Y Chau; T Mori; KA Dookeran; Joshua Rubin; S Watkins; Paul D Robbins; Michael T Lotze; Hideaki Tahara
Potent antitumor effects of intra-arterial injection of fibroblasts genetically engineered to express IL-12 in liver metastasis model of rat: no additional benefit of using retroviral producer cell.
Cancer gene therapy 2001;8(1):17-22.
2001: Darren Wolfe; William F Goins; T J Kaplan; Saverio Capuano; J Fradette; M Murphey-Corb; Paul D Robbins; Justus B Cohen; Joseph C Glorioso
Herpesvirus-mediated systemic delivery of nerve growth factor.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(1):61-9.
2000: J Mai; Paul D Robbins
Targeting gene therapy for transplantation with venom.
Transplantation 2000;70(11):1553-4.
2000: Andrea Gambotto; Grzegorz Dworacki; Vito R Cicinnati; TW Kenniston; Julia Steitz; Thomas Tüting; Paul D Robbins; Albert B DeLeo
Immunogenicity of enhanced green fluorescent protein (EGFP) in BALB/c mice: identification of an H2-Kd-restricted CTL epitope.
Gene therapy 2000;7(23):2036-40.
2000: Nick Giannoukakis; William A Rudert; Massimo Trucco; Paul D Robbins
Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor.
The Journal of biological chemistry 2000;275(47):36509-13.
2000: JL Siegert; JJ Rushton; William R Sellers; William G Kaelin; Paul D Robbins
Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity.
Oncogene 2000;19(50):5703-11.
2000: Zhibao Mi; Steven C Ghivizzani; Eric R Lechman; D Jaffurs; Joseph C Glorioso; Christopher H Evans; Paul D Robbins
Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints.
Arthritis and rheumatism 2000;43(11):2563-70.
2000: S H Moon; Lars G Gilbertson; K Nishida; M Knaub; Thomas S Muzzonigro; Paul D Robbins; Christopher H Evans; James D Kang
Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders.
Spine 2000;25(20):2573-9.
2000: Christopher H Evans; Steven C Ghivizzani; James H Herndon; Mary Chester Wasko; Julio A Reinecke; Peter Wehling; Paul D Robbins
Clinical trials in the gene therapy of arthritis.
Clinical orthopaedics and related research 2000;(379 Suppl):S300-7.
2000: Steven C Ghivizzani; Thomas J Oligino; J C Glorioso; Paul D Robbins; Christopher H Evans
Gene therapy approaches for treating rheumatoid arthritis.
Clinical orthopaedics and related research 2000;(379 Suppl):S288-99.
2000: K Nishida; Lars G Gilbertson; Paul D Robbins; Christopher H Evans; James D Kang
Potential applications of gene therapy to the treatment of intervertebral disc disorders.
Clinical orthopaedics and related research 2000;(379 Suppl):S234-41.
2000: Christopher H Evans; Steven C Ghivizzani; P Smith; FD Shuler; Z Mi; Paul D Robbins
Using gene therapy to protect and restore cartilage.
Clinical orthopaedics and related research 2000;(379 Suppl):S214-9.
2000: Alan J Nixon; Brent Brower-Toland; Stephen J Bent; RA Saxer; Markus Wilke; Paul D Robbins; Chris H Evans
Insulinlike growth factor-I gene therapy applications for cartilage repair.
Clinical orthopaedics and related research 2000;(379 Suppl):S201-13.
2000: Axel W A Baltzer; christian lattermann; Janey D Whalen; Steven C Ghivizzani; Paul H Wooley; Rüdiger Krauspe; Paul D Robbins; Christopher H Evans
Potential role of direct adenoviral gene transfer in enhancing fracture repair.
Clinical orthopaedics and related research 2000;(379 Suppl):S120-5.
2000: Zhibao Mi; Jeffrey C Mai; X Lu; Paul D Robbins
Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(4):339-47.
2000: Adrian E Morelli; Adriana T Larregina; Raymond W Ganster; Alan F Zahorchak; Jeffrey Plowey; T Takayama; Alison J Logar; Paul D Robbins; Louis Falo; Angus W Thomson
Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathway.
Journal of virology 2000;74(20):9617-28.
2000: Fumiaki Tanaka; Wataru Hashimoto; Haruki Okamura; Paul D Robbins; Michael T Lotze; Hideaki Tahara
Rapid generation of potent and tumor-specific cytotoxic T lymphocytes by interleukin 18 using dendritic cells and natural killer cells.
Cancer research 2000;60(17):4838-44.
2000: Georgi Pirtskhalaishvili; Galina V Shurin; Andrea Gambotto; Clemens Esche; M Wahl; Zoya R Yurkovetsky; Paul D Robbins; Michael R Shurin
Transduction of dendritic cells with Bcl-xL increases their resistance to prostate cancer-induced apoptosis and antitumor effect in mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1956-64.
2000: T Takayama; Adrian E Morelli; Paul D Robbins; Hideaki Tahara; Angus W Thomson
Feasibility of CTLA4Ig gene delivery and expression in vivo using retrovirally transduced myeloid dendritic cells that induce alloantigen-specific T cell anergy in vitro.
Gene therapy 2000;7(15):1265-73.
2000: H Goto; FD Shuler; Christopher Niyibizi; Freddie H Fu; Paul D Robbins; Christopher H Evans
Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(4):266-71.
2000: R Kang; Steven C Ghivizzani; Thomas S Muzzonigro; James H Herndon; Paul D Robbins; Christopher H Evans
The Marshall R. Urist Young Investigator Award. Orthopaedic applications of gene therapy. From concept to clinic.
Clinical orthopaedics and related research 2000;(375):324-37.
2000: Toru Kubota; GS Bounoutas; M Miyagishima; Toshiaki Kadokami; VJ Sanders; C Bruton; Paul D Robbins; Charles F McTiernan; Arthur M Feldman
Soluble tumor necrosis factor receptor abrogates myocardial inflammation but not hypertrophy in cytokine-induced cardiomyopathy.
Circulation 2000;101(21):2518-25.
2000: K Suzuki; M Oyama; L Faulcon; Paul D Robbins; Christopher Niyibizi
In vivo expression of human growth hormone by genetically modified murine bone marrow stromal cells and its effect on the cells in vitro.
Cell transplantation 2000;9(3):319-27.
2000: Nick Giannoukakis; C Andrew Bonham; Shiguang Qian; Z Chen; L Peng; Jo Harnaha; W Li; Angus W Thomson; John J Fung; Paul D Robbins; Lina Lu; Z Zhou
Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(5 Pt 1):430-7.
2000: Q Yao; Joseph C Glorioso; C H Evans; Paul D Robbins; Imre Kovesdi; Thomas J Oligino; Steven C Ghivizzani
Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining.
The journal of gene medicine 2000;2(3):210-9.
2000: Axel W A Baltzer; christian lattermann; Janey D Whalen; Paul H Wooley; K Weiss; Michele J Grimm; Steven C Ghivizzani; Paul D Robbins; Christopher H Evans
Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene.
Gene therapy 2000;7(9):734-9.
2000: P Smith; FD Shuler; Helga I Georgescu; Steven C Ghivizzani; B Johnstone; Christopher Niyibizi; Paul D Robbins; Christopher H Evans
Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1.
Arthritis and rheumatism 2000;43(5):1156-64.
2000: M Hirao; N Onai; Kazumasa Hiroishi; simon simon watkins; K Matsushima; Paul D Robbins; Michael T Lotze; Hideaki Tahara
CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes.
Cancer research 2000;60(8):2209-17.
2000: HD Möller; Freddie H Fu; Christopher Niyibizi; Rebecca K Studer; H J Georgescu; Paul D Robbins; Christopher H Evans
[TGF-beta-1 gene transfer in joint cartilage cells. Stimulating effect in extracellular matrix synthesis].
Der Orthopäde 2000;29(2):75-9.
2000: Michael T Lotze; Michael R Shurin; Clemens Esche; Hideaki Tahara; Walter J Storkus; John M Kirkwood; Theresa L Whiteside; Elaine Elder; H Okada; Paul D Robbins
Interleukin-2: developing additional cytokine gene therapies using fibroblasts or dendritic cells to enhance tumor immunity.
The cancer journal from Scientific American 2000;6 Suppl 1():S61-6.
2000: Andrea Gambotto; Vito R Cicinnati; Paul D Robbins
Genetic approaches for biologic therapy of cancer.
Drugs of today (Barcelona, Spain : 1998) 2000;36(1):25-39.
2000: S H Kim; Christopher H Evans; S Kim; Thomas J Oligino; Steven C Ghivizzani; Paul D Robbins
Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4.
Arthritis research 2000;2(4):293-302.
2000: Andrea Gambotto; Seon-Hee Kim; S Kim; Paul D Robbins
Methods for constructing and producing retroviral vectors.
Methods in molecular biology (Clifton, N.J.) 2000;135():495-508.
1999: K Nishida; James D Kang; Lars G Gilbertson; S H Moon; J K Suh; Molly T Vogt; Paul D Robbins; Christopher H Evans
Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene.
Spine 1999;24(23):2419-25.
1999: Nick Giannoukakis; William A Rudert; Paul D Robbins; Massimo Trucco
Targeting autoimmune diabetes with gene therapy.
Diabetes 1999;48(11):2107-21.
1999: Axel W A Baltzer; Janey D Whalen; M Stefanovic-Racic; B Ziran; Paul D Robbins; Christopher H Evans
Adenoviral transduction of human osteoblastic cell cultures: a new perspective for gene therapy of bone diseases.
Acta orthopaedica Scandinavica 1999;70(5):419-24.
1999: Christopher H Evans; Paul D Robbins
Genetically augmented tissue engineering of the musculoskeletal system.
Clinical orthopaedics and related research 1999;(367 Suppl):S410-8.
1999: Nick Giannoukakis; William A Rudert; Steven C Ghivizzani; Andrea Gambotto; Camillo Ricordi; Massimo Trucco; Paul D Robbins
Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.
Diabetes 1999;48(9):1730-6.
1999: Y Nishioka; M Hirao; Paul D Robbins; Michael T Lotze; Hideaki Tahara
Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12.
Cancer research 1999;59(16):4035-41.
1999: Eric R Lechman; D Jaffurs; Steven C Ghivizzani; Andrea Gambotto; Imre Kovesdi; Zhibao Mi; Christopher H Evans; Paul D Robbins
Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2202-8.
1999: Lina Lu; WC Lee; T Takayama; Shiguang Qian; Andrea Gambotto; Paul D Robbins; Angus W Thomson
Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-beta, and CTLA4Ig).
Journal of leukocyte biology 1999;66(2):293-6.
1999: Wataru Hashimoto; T Osaki; Haruki Okamura; Paul D Robbins; M Kurimoto; S Nagata; Michael T Lotze; Hideaki Tahara
Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):583-9.
1999: H Goto; FD Shuler; C Lamsam; H D Moller; Christopher Niyibizi; Freddie H Fu; Paul D Robbins; Christopher H Evans
Transfer of lacZ marker gene to the meniscus.
The Journal of bone and joint surgery. American volume 1999;81(7):918-25.
1999: Clemens Esche; Andrea Gambotto; Y Satoh; Valentin Gerein; Paul D Robbins; simon simon watkins; Michael T Lotze; Michael R Shurin
CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth.
European journal of immunology 1999;29(7):2148-55.
1999: Rebecca K Studer; D Jaffurs; Maja Stefanovic-Racic; Paul D Robbins; Christopher H Evans
Nitric oxide in osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(4):377-9.
1999: Douglas S Musgrave; Patrick P Bosch; Steven C Ghivizzani; Paul D Robbins; Christopher H Evans; Johnny Huard
Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone.
Bone 1999;24(6):541-7.
1999: T Osaki; Wataru Hashimoto; Andrea Gambotto; Haruki Okamura; Paul D Robbins; M Kurimoto; Michael T Lotze; Hideaki Tahara
Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18).
Gene therapy 1999;6(5):808-15.
1999: Christopher H Evans; Paul D Robbins
Potential treatment of osteoarthritis by gene therapy.
Rheumatic diseases clinics of North America 1999;25(2):333-44.
1999: Steven C Ghivizzani; Thomas S Muzzonigro; R Kang; Christopher H Evans; Paul D Robbins
Clinical gene therapy for arthritis.
Drugs of today (Barcelona, Spain : 1998) 1999;35(4-5):389-96.
1999: Paul D Robbins; Christopher H Evans
Arthritis gene therapy.
Drugs of today (Barcelona, Spain : 1998) 1999;35(4-5):353-60.
1999: Thomas Tüting; Andrea Gambotto; Paul D Robbins; Walter J Storkus; Albert B DeLeo
Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: studies with the model tumor antigen beta-galactosidase and the BALB/c Meth A p53 tumor-specific antigen.
Gene therapy 1999;6(4):629-36.
1999: Lina Lu; Andrea Gambotto; WC Lee; Shiguang Qian; C Andrew Bonham; Paul D Robbins; Angus W Thomson
Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients.
Gene therapy 1999;6(4):554-63.
1999: Axel W A Baltzer; Janey D Whalen; T Muzzonegro; H I Georgescu; Paul D Robbins; Christopher H Evans
[In vitro transduction of human osteoblast cell populations with retroviral vectors].
Zeitschrift für Rheumatologie 1999;58(2):88-94.
1999: Christopher H Evans; JJ Rediske; S B Abramson; Paul D Robbins
Joint efforts: tackling arthritis using gene therapy. First International Meeting on the Gene Therapy of Arthritis and Related Disorders. Bethesda, MD, USA, 2-3 December 1998.
Molecular medicine today 1999;5(4):148-51.
1999: J D Whalen; E L Lechman; Casey A Carlos; K Weiss; Imre Kovesdi; Joseph C Glorioso; Paul D Robbins; Christopher H Evans
Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3625-32.
1999: M Oyama; A Tatlock; S Fukuta; KW Kavalkovich; K Nishimura; B Johnstone; Paul D Robbins; Christopher H Evans; Christopher Niyibizi
Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging.
Gene therapy 1999;6(3):321-9.
1999: Lina Lu; WC Lee; Andrea Gambotto; C Zhong; Paul D Robbins; Shiguang Qian; John J Fung; Angus W Thomson
Transduction of dendritic cells with adenoviral vectors encoding CTLA4-Ig markedly reduces their allostimulatory activity.
Transplantation proceedings 1999;31(1-2):797.
1999: J Adnane; Z Shao; Paul D Robbins
Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription.
Oncogene 1999;18(1):239-47.
1999: Christopher H Evans; Steven C Ghivizzani; Eric R Lechman; Zhibao Mi; D Jaffurs; Paul D Robbins
Lessons learned from gene transfer approaches.
Arthritis research 1999;1(1):21-4.
1999: Axel W A Baltzer; christian lattermann; Janey D Whalen; S Braunstein; Paul D Robbins; Christopher H Evans
A gene therapy approach to accelerating bone healing. Evaluation of gene expression in a New Zealand white rabbit model.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 1999;7(3):197-202.
1999: Thomas Tüting; Andrea Gambotto; Albert B DeLeo; Michael T Lotze; Paul D Robbins; Walter J Storkus
Induction of tumor antigen-specific immunity using plasmid DNA immunization in mice.
Cancer gene therapy 1999;6(1):73-80.
1999: Andrea Gambotto; Thomas Tüting; D L McVey; Imre Kovesdi; Hideaki Tahara; Michael T Lotze; Paul D Robbins
Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12.
Cancer gene therapy 1999;6(1):45-53.
1999: KA Hildebrand; M Deie; Christina R Allen; DW Smith; Helga I Georgescu; Christopher H Evans; Paul D Robbins; Savio L-Y. Woo
Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: the use of different viral vectors and the effects of injury.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(1):37-42.
1999: Thomas S Muzzonigro; Steven C Ghivizzani; Paul D Robbins; Christopher H Evans
The role of gene therapy. Fact or fiction?
Clinics in sports medicine 1999;18(1):223-39, vii-viii.
1999: Christopher H Evans; Steven C Ghivizzani; Richard Kang; Thomas S Muzzonigro; Mary Chester Wasko; James H Herndon; Paul D Robbins
Gene therapy for rheumatic diseases.
Arthritis and rheumatism 1999;42(1):1-16.
1999: JL Siegert; Paul D Robbins
Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250.
Molecular and cellular biology 1999;19(1):846-54.
1998: W C Lee; C Zhong; Shiguang Qian; Yonghong Wan; J Gauldie; Z Mi; Paul D Robbins; Angus W Thomson; Lina Lu
Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-beta.
Transplantation 1998;66(12):1810-7.
1998: K Nishida; James D Kang; J K Suh; Paul D Robbins; Christopher H Evans; Lars G Gilbertson
Adenovirus-mediated gene transfer to nucleus pulposus cells. Implications for the treatment of intervertebral disc degeneration.
Spine 1998;23(22):2437-42; discussion 2443.
1998: Christopher Niyibizi; Axel W A Baltzer; christian lattermann; M Oyama; Janey D Whalen; Paul D Robbins; Christopher H Evans
Potential role for gene therapy in the enhancement of fracture healing.
Clinical orthopaedics and related research 1998;(355 Suppl):S148-53.
1998: Paul D Robbins; Steven C Ghivizzani
Viral vectors for gene therapy.
Pharmacology & therapeutics 1998;80(1):35-47.
1998: C H Evans; S C Ghivizzani; Paul D Robbins
Blocking cytokines with genes.
Journal of leukocyte biology 1998;64(1):55-61.
1998: Bettina Couderc; L Zitvogel; Victorine Douin-Echinard; L Djennane; Hideaki Tahara; Gilles FAVRE; Michael T Lotze; Paul D Robbins
Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells.
Cancer gene therapy 1998;5(3):163-75.
1998: Steven C Ghivizzani; Eric R Lechman; Richard Kang; C Tio; Jay K Kolls; Christopher H Evans; Paul D Robbins
Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4613-8.
1998: T Osaki; JM Péron; Q Cai; Haruki Okamura; Paul D Robbins; M Kurimoto; Michael T Lotze; Hideaki Tahara
IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1742-9.
1998: C Lamsam; Freddie H Fu; Paul D Robbins; Christopher H Evans
Gene therapy in sports medicine.
Sports medicine (Auckland, N.Z.) 1998;25(2):73-7.
1998: Victorine Douin-Echinard; Paul D Robbins; Michael T Lotze; Gilles FAVRE; Bettina Couderc
Enhancement of anti-tumor immunity by injection of fibroblasts genetically engineered to produce IL-12 and to express CD70.
Advances in experimental medicine and biology 1998;451():353-7.
1998: Paul D Robbins; Christopher H Evans; Y Chernajovsky
Gene therapy for rheumatoid arthritis.
Springer seminars in immunopathology 1998;20(1-2):197-209.
1998: Paul D Robbins; Hideaki Tahara; Steven C Ghivizzani
Viral vectors for gene therapy.
Trends in biotechnology 1998;16(1):35-40.
1997: Thomas Tüting; Andrea Gambotto; Joseph Baar; I D Davis; Walter J Storkus; Paul J Zavodny; Satwant K Narula; Hideaki Tahara; Paul D Robbins; Michael T Lotze
Interferon-alpha gene therapy for cancer: retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models.
Gene therapy 1997;4(10):1053-60.
1997: JJ Rushton; Richard A Steinman; Paul D Robbins
Differential regulation of transcription of p21 and cyclin D1 conferred by TAF(II)250.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(10):1099-104.
1997: Steven C Ghivizzani; Richard Kang; Helga I Georgescu; Eric R Lechman; D Jaffurs; J M Engle; simon simon watkins; M H Tindal; M K Suchanek; L R McKenzie; Christopher H Evans; Paul D Robbins
Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3604-12.
1997: Steven C Ghivizzani; Eric R Lechman; C Tio; Karen Mulé; Sunil Chada; JE McCormack; Christopher H Evans; Paul D Robbins
Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy.
Gene therapy 1997;4(9):977-82.
1997: Z Shao; JL Siegert; S Ruppert; Paul D Robbins
Rb interacts with TAF(II)250/TFIID through multiple domains.
Oncogene 1997;15(4):385-92.
1997: JJ Rushton; D Jiang; Alagarsamy Srinivasan; James M Pipas; Paul D Robbins
Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.
Journal of virology 1997;71(7):5620-3.
1997: Torsten G Gerich; S Ghivizani; Freddie H Fu; Paul D Robbins; Christopher H Evans
[Gene transfer into the patellar tendon of rabbits: a preliminary study of locoregional expression of growth factors].
Wiener klinische Wochenschrift 1997;109(11):384-9.
1997: Peter Wehling; KP Schulitz; Paul D Robbins; Christopher H Evans; Julio A Reinecke
Transfer of genes to chondrocytic cells of the lumbar spine. Proposal for a treatment strategy of spinal disorders by local gene therapy.
Spine 1997;22(10):1092-7.
1997: Torsten G Gerich; Philipp Lobenhoffer; Freddie H Fu; Paul D Robbins; Christopher H Evans
[Possibilities of gene therapy in traumatic and degenerative articular lesions. Current status of experimental and initial clinical applications].
Der Orthopäde 1997;26(5):450-8.
1997: Richard Kang; Steven C Ghivizzani; James H Herndon; Paul D Robbins; Christopher H Evans
Gene therapy for arthritis: principles and clinical practice.
Biochemical Society transactions 1997;25(2):533-7.
1997: Richard Kang; T Marui; Steven C Ghivizzani; I M Nita; Helga I Georgescu; Jun-Kyo Francis Suh; Paul D Robbins; Christopher H Evans
Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(2):139-43.
1997: Lesley A Doughty; Ken Patrene; Christopher H Evans; SS Boggs; Paul D Robbins
Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10.
Gene therapy 1997;4(3):252-7.
1997: Torsten G Gerich; R Kang; Freddie H Fu; Paul D Robbins; Christopher H Evans
Gene transfer to the patellar tendon.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 1997;5(2):118-23.
1996: Torsten G Gerich; Richard Kang; Freddie H Fu; Paul D Robbins; Christopher H Evans
Gene transfer to the rabbit patellar tendon: potential for genetic enhancement of tendon and ligament healing.
Gene therapy 1996;3(12):1089-93.
1996: Michael T Lotze; L Zitvogel; R Campbell; Paul D Robbins; Elaine Elder; Catherine Haluszczak; D Martin; Theresa L Whiteside; Walter J Storkus; Hideaki Tahara
Cytokine gene therapy of cancer using interleukin-12: murine and clinical trials.
Annals of the New York Academy of Sciences 1996;795():440-54.
1996: L Zitvogel; Bettina Couderc; José I Mayordomo; Paul D Robbins; Michael T Lotze; Walter J Storkus
IL-12-engineered dendritic cells serve as effective tumor vaccine adjuvants in vivo.
Annals of the New York Academy of Sciences 1996;795():284-93.
1996: Hideaki Tahara; L Zitvogel; Walter J Storkus; Paul D Robbins; Michael T Lotze
Murine models of cancer cytokine gene therapy using interleukin-12.
Annals of the New York Academy of Sciences 1996;795():275-83.
1996: R A Henderson; M T Nimgaonkar; simon simon watkins; Paul D Robbins; Edward D Ball; Olivera J Finn
Human dendritic cells genetically engineered to express high levels of the human epithelial tumor antigen mucin (MUC-1).
Cancer research 1996;56(16):3763-70.
1996: R M Berman; T Suzuki; Hideaki Tahara; Paul D Robbins; S K Narula; Michael T Lotze
Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):231-8.
1996: Christopher H Evans; Paul D Robbins; Steven C Ghivizzani; James H Herndon; Richard Kang; Alfred B Bahnson; John A Barranger; E M Elders; S Gay; Matthew M Tomaino; Mary Chester Wasko; simon simon watkins; Theresa L Whiteside; Joseph C Glorioso; Michael T Lotze; T M Wright
Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis.
Human gene therapy 1996;7(10):1261-80.
1996: L Zitvogel; Paul D Robbins; Walter J Storkus; MR Clarke; Markus J Maeurer; R L Campbell; C G Davis; Hideaki Tahara; R D Schreiber; Michael T Lotze
Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors.
European journal of immunology 1996;26(6):1335-41.
1996: I Nita; Steven C Ghivizzani; J Galea-Lauri; G Bandara; Helga I Georgescu; Paul D Robbins; Christopher H Evans
Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo.
Arthritis and rheumatism 1996;39(5):820-8.
1996: K Otani; I Nita; William Macaulay; Helga I Georgescu; Paul D Robbins; Christopher H Evans
Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3558-62.
1996: Edith Tzeng; Lawrence Shears; Paul D Robbins; Bruce R Pitt; David A Geller; simon simon watkins; Richard L Simmons; Timothy R Billiar
Vascular gene transfer of the human inducible nitric oxide synthase: characterization of activity and effects on myointimal hyperplasia.
Molecular medicine (Cambridge, Mass.) 1996;2(2):211-25.
1996: Torsten G Gerich; Freddie H Fu; Paul D Robbins; Christopher H Evans
Prospects for gene therapy in sports medicine.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 1996;4(3):180-7.
1996: Christopher H Evans; Paul D Robbins
The promise of a new clinical trial--intra-articular IL-1 receptor antagonist.
Proceedings of the Association of American Physicians 1996;108(1):1-5.
1996: Steven T DeKosky; Scot D Styren; Mark E O'Malley; James R Goss; Patrick M Kochanek; D Marion; Christopher H Evans; Paul D Robbins
Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain.
Annals of neurology 1996;39(1):123-7.
1995: Edith Tzeng; Timothy R Billiar; Paul D Robbins; M Loftus; D J Stuehr
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11771-5.
1995: Hideaki Tahara; Michael T Lotze; Paul D Robbins; Walter J Storkus; L Zitvogel
IL-12 gene therapy using direct injection of tumors with genetically engineered autologous fibroblasts.
Human gene therapy 1995;6(12):1607-24.
1995: SS Boggs; Ken Patrene; G M Mueller; Christopher H Evans; Lesley A Doughty; Paul D Robbins
Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA.
Gene therapy 1995;2(9):632-8.
1995: G M Mueller; L R McKenzie; Gregg E Homanics; simon simon watkins; Paul D Robbins; H S Paul
Complementation of defective leucine decarboxylation in fibroblasts from a maple syrup urine disease patient by retrovirus-mediated gene transfer.
Gene therapy 1995;2(7):461-8.
1995: L Zitvogel; Hideaki Tahara; Paul D Robbins; Walter J Storkus; MR Clarke; M A Nalesnik; Michael T Lotze
Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1393-403.
1995: T Suzuki; Hideaki Tahara; S Narula; K W Moore; Paul D Robbins; Michael T Lotze
Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors.
The Journal of experimental medicine 1995;182(2):477-86.
1995: Bruce R Pitt; M A Schwarz; Joseph M Pilewski; Don K Nakayama; G M Mueller; Paul D Robbins; S A Watkins; K H Albertine; R D Bland
Retrovirus-mediated gene transfer in lungs of living fetal sheep.
Gene therapy 1995;2(5):344-50.
1995: Christopher H Evans; Paul D Robbins
Possible orthopaedic applications of gene therapy.
The Journal of bone and joint surgery. American volume 1995;77(7):1103-14.
1995: Hideaki Tahara; L Zitvogel; Walter J Storkus; H J Zeh; T G McKinney; R D Schreiber; U Gubler; Paul D Robbins; Michael T Lotze
Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6466-74.
1995: M A Schwarz; John Lazo; Jack C Yalowich; W P Allen; Mark Whitmore; H A Bergonia; Edith Tzeng; Timothy R Billiar; Paul D Robbins; JR Lancaster
Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4452-6.
1995: J Adnane; Z Shao; Paul D Robbins
The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter.
The Journal of biological chemistry 1995;270(15):8837-43.
1995: Z Shao; S Ruppert; Paul D Robbins
The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3115-9.
1995: J Adnane; Paul D Robbins
The retinoblastoma susceptibility gene product regulates Myc-mediated transcription.
Oncogene 1995;10(2):381-7.
1995: Z Shao; Paul D Robbins
Differential regulation of E2F and Sp1-mediated transcription by G1 cyclins.
Oncogene 1995;10(2):221-8.
1994: L Zitvogel; Hideaki Tahara; Q Cai; Walter J Storkus; G Muller; Stanley Wolf; M Gately; Paul D Robbins; Michael T Lotze
Construction and characterization of retroviral vectors expressing biologically active human interleukin-12.
Human gene therapy 1994;5(12):1493-506.
1994: N Ohtani-Fujita; T Fujita; R Takahashi; Paul D Robbins; Thaddeus P Dryja; Toshiyuki Sakai
A silencer element in the retinoblastoma tumor-suppressor gene.
Oncogene 1994;9(6):1703-11.
1994: Paul D Robbins; Hideaki Tahara; G Mueller; G Hung; Alfred B Bahnson; L Zitvogel; J Galea-Lauri; T Ohashi; Ken Patrene; SS Boggs
Retroviral vectors for use in human gene therapy for cancer, Gaucher disease, and arthritis.
Annals of the New York Academy of Sciences 1994;716():72-88; discussion 88-9.
1994: Xiang Gao; D Jaffurs; Paul D Robbins; Leaf Huang
A sustained, cytoplasmic transgene expression system delivered by cationic liposomes.
Biochemical and biophysical research communications 1994;200(3):1201-6.
1994: Alfred B Bahnson; M Nimgaonkar; Y Fei; SS Boggs; Paul D Robbins; T Ohashi; James T Dunigan; J Li; Edward D Ball; John A Barranger
Transduction of CD34+ enriched cord blood and Gaucher bone marrow cells by a retroviral vector carrying the glucocerebrosidase gene.
Gene therapy 1994;1(3):176-84.
1994: N E Osifchin; D Jiang; N Ohtani-Fujita; T Fujita; M Carroza; S J Kim; T Sakai; Paul D Robbins
Identification of a p53 binding site in the human retinoblastoma susceptibility gene promoter.
The Journal of biological chemistry 1994;269(9):6383-9.
1994: Christopher H Evans; Paul D Robbins
The interleukin-1 receptor antagonist and its delivery by gene transfer.
Receptor 1994;4(1):9-15.
1994: Hideaki Tahara; H J Zeh; Walter J Storkus; I Pappo; simon simon watkins; U Gubler; Stanley Wolf; Paul D Robbins; Michael T Lotze
Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.
Cancer research 1994;54(1):182-9.
1994: G L Hung; J Galea-Lauri; G M Mueller; Helga I Georgescu; L A Larkin; M K Suchanek; M H Tindal; Paul D Robbins; Christopher H Evans
Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium.
Gene therapy 1994;1(1):64-9.
1993: G Bandara; G M Mueller; J Galea-Lauri; M H Tindal; Helga I Georgescu; M K Suchanek; G L Hung; Joseph C Glorioso; Paul D Robbins; Christopher H Evans
Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10764-8.
1993: D Jiang; Alagarsamy Srinivasan; G Lozano; Paul D Robbins
SV40 T antigen abrogates p53-mediated transcriptional activity.
Oncogene 1993;8(10):2805-12.
1993: N Ohtani-Fujita; T Fujita; A Aoike; N E Osifchin; Paul D Robbins; Toshiyuki Sakai
CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene.
Oncogene 1993;8(4):1063-7.
1992: H Tahara; G M Mueller; Camillo Ricordi; Paul D Robbins; Michael T Lotze
Islet cell transplantation facilitated by gene transfer.
Transplantation proceedings 1992;24(6):2975-6.
1992: G Bandara; Paul D Robbins; Helga I Georgescu; G M Mueller; Joseph C Glorioso; Christopher H Evans
Gene transfer to synoviocytes: prospects for gene treatment of arthritis.
DNA and cell biology 1992;11(3):227-31.
1987: Wendell L Roelofs; T Glover; X H Tang; I Sreng; Paul D Robbins; C Eckenrode; C Löfstedt; B S Hansson; B O Bengtsson
Sex pheromone production and perception in European corn borer moths is determined by both autosomal and sex-linked genes.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7585-9.