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Andrew Roberts

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Mary Ann Anderson; David C S Huang; Andrew W Roberts
BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia.
Jianlin Qiao; Andrew W Roberts; Simone M Schoenwaelder; Huy Tran; Shaun P Jackson; Zane S Kaplan; Benjamin T Kile; Kylie D Mason; Robert K Andrews; Amanda K Davis; Elizabeth E Gardiner
Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).
Kylie D Mason; Daniel H D Gray; Katya J Henley; David C S Huang; Emma C Josefsson; Benjamin T Kile; Ann Lin; Lorraine Robb; Andrew W Roberts; Andreas Strasser; Paul Waring; Lorraine A O'Reilly
Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease.

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All Publications

2013: Mary Ann Anderson; David C S Huang; Andrew W Roberts
BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia.
Leukemia & lymphoma 2013;54(5):909-11.
2013: Jianlin Qiao; Andrew W Roberts; Simone M Schoenwaelder; Huy Tran; Shaun P Jackson; Zane S Kaplan; Benjamin T Kile; Kylie D Mason; Robert K Andrews; Amanda K Davis; Elizabeth E Gardiner
Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).
Blood 2013;121(8):1479-81.
2013: Kylie D Mason; Daniel H D Gray; Katya J Henley; David C S Huang; Emma C Josefsson; Benjamin T Kile; Ann Lin; Lorraine Robb; Andrew W Roberts; Andreas Strasser; Paul Waring; Lorraine A O'Reilly
Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(7):2599-604.
2012: Delphine Mérino; Belinda Phipson; Mikara Robati; Andrew W Roberts; Cassandra J Vandenberg; Chihunt Wong; Peng Yue; Daniel J Anderson; Lisa D Belmont; Kirsteen J Campbell; Suzanne Cory; W Douglas Fairlie; Stefan P Glaser; David C S Huang; Seong L Khaw; Erinna Lee; Mary J C Ludlam; Philippe Bouillet
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.
Blood 2012;119(24):5807-16.
2012: Marlyse A Debrincat; Sarah Ellis; Natasha L Harvey; Katya J Henley; Chloé James; Emma C Josefsson; Rachael M Lane; Marion Lebois; Donald Metcalf; Andrew W Roberts; Kelly L Rogers; Michael J White; Kelly L Betterman; Benjamin T Kile
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
Blood 2012;119(24):5850-8.
2012: Andrew W Roberts; John F Seymour; William G Wierda; Hao Xiong; Seong Lin Khaw; Thomas J Kipps; Andrew Krivoshik; Evelyn M McKeegan; Jennifer R Brown; Todd A Busman; Dennis A Carney; Yue Cui; Sari H Enschede; Simon Z He; David C S Huang; Rod A Humerickhouse
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(5):488-96.
2012: L M Lindqvist; K McArthur; Mark A Rizzacasa; Andrew W Roberts; Andreas Strasser; I Vikström; M Ann Anderson; C J Burns; J M Chambers; Leonie A Cluse; Ben A Croker; L Happo; K J Henley; Ricky Johnstone; Benjamin T Kile; D C S Huang
Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor.
Cell death & disease 2012;3():e409.
2011: Emma C Josefsson; Marlyse A Debrincat; Mark R Dowling; Sarah Ellis; Katya J Henley; David C S Huang; Chloé James; Elizabeth A Kruse; Rachael M Lane; Kylie D Mason; Donald Metcalf; Paquita Nurden; Lorraine A O'Reilly; Andrew W Roberts; Kelly L Rogers; Michael J White; Benjamin T Kile
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.
The Journal of experimental medicine 2011;208(10):2017-31.
2011: Simone M Schoenwaelder; Michael J White; Abbey Willcox; Imala Alwis; Robert K Andrews; Elizabeth E Gardiner; My Hua; David C S Huang; Kate E Jarman; Emma C Josefsson; Benjamin T Kile; Kylie D Mason; Akiko Ono; Jianlin Qiao; Andrew W Roberts; Hatem H Salem; Shaun P Jackson
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets.
Blood 2011;118(6):1663-74.
2011: Ben A Croker; Grant Dewson; Yifang Hu; Kurt Lackovic; Donald Metcalf; Cameron Nowell; Joanne A O'Donnell; Lorraine A O'Reilly; Philippe Bouillet; Kirsteen J Campbell; Louise H Cengia; Suzanne Cory; Kelly L Rogers; Gordon K Smyth; Andreas Strasser; Michael White; Jian-Guo Zhang; Andrew W Roberts
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(32):13135-40.
2011: Ben A Croker; Rowena S Lewis; Jeff J Babon; Justine D Mintern; Dieter E Jenne; Donald Metcalf; Jian-Guo Zhang; Louise H Cengia; Joanne A O'Donnell; Andrew W Roberts
Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(2):1131-9.
2010: Geoffrey R Hill; Rachel D Kuns; Neil C Raffelt; Alistair L Don; Stuart Olver; Kate A Markey; Yana A Wilson; Joel Tocker; Warren S Alexander; Andrew D Clouston; Andrew W Roberts; Kelli P A MacDonald
SOCS3 regulates graft-versus-host disease.
Blood 2010;116(2):287-96.
2010: Michael Dickinson; Rosemary Hoyt; Andrew W Roberts; Andrew Grigg; John F Seymour; H Miles Prince; Jeff Szer; David Ritchie
Improved survival for relapsed diffuse large B cell lymphoma is predicted by a negative pre-transplant FDG-PET scan following salvage chemotherapy.
British journal of haematology 2010;150(1):39-45.
2010: Marc Kvansakul; Andrew H Wei; Jamie I Fletcher; Simon N Willis; Lin Chen; Andrew W Roberts; David C S Huang; Peter M Colman
Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS pathogens 2010;6(12):e1001236.
2009: Seong L Khaw; David C S Huang; Andrew W Roberts
BH3-mimetics--the solution to chemoresistance?
Leukemia & lymphoma 2009;50(7):1069-72.
2008: Jo L Eyles; Michael J Hickey; M Ursula Norman; Ben A Croker; Andrew W Roberts; Sarah F Drake; Will G James; Donald Metcalf; Ian K Campbell; Ian P Wicks
A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis.
Blood 2008;112(13):5193-201.
2008: Kylie D Mason; Cassandra J Vandenberg; Clare L Scott; Andrew H Wei; Suzanne Cory; David C S Huang; Andrew W Roberts
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17961-6.
2008: Ben A Croker; Lisa A Mielke; Samuel Wormald; Donald Metcalf; Hiu Kiu; Warren S Alexander; Douglas J Hilton; Andrew W Roberts
Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation.
Experimental hematology 2008;36(7):786-98.
2008: R Hoyt; David S Ritchie; Andrew W Roberts; Lachlan MacGregor; David J Curtis; Jeff Szer; Andrew P Grigg
Cyclosporin, methotrexate and prednisolone for graft-versus-host disease prophylaxis in allogeneic peripheral blood progenitor cell transplants.
Bone marrow transplantation 2008;41(7):651-8.
2007: Hiu Kiu; Douglas J Hilton; Nicos A Nicola; Matthias Ernst; Rodolfo Marquez; Warren S Alexander; Andrew W Roberts; Edward J McManus
Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha.
Growth factors (Chur, Switzerland) 2007;25(5):319-28.
2007: Kristy Boyle; Paul J Egan; Steven Rakar; Tracy A Willson; Ian P Wicks; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Warren S Alexander; Andrew W Roberts; Lorraine Robb
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.
Blood 2007;110(5):1466-74.
2007: Monica A Slavin; Andrew P Grigg; Anthony P Schwarer; Jeff Szer; A Spencer; A Sainani; Karin Thursky; Andrew W Roberts
A randomized comparison of empiric or pre-emptive antibiotic therapy after hematopoietic stem cell transplantation.
Bone marrow transplantation 2007;40(2):157-63.
2007: Andrew P Grigg; J Gibson; Peter Bardy; John Reynolds; Peter Shuttleworth; R L Koelmeyer; Jeff Szer; Andrew W Roberts; L Bik To; G Kennedy; Kenneth F Bradstock
A prospective multicenter trial of peripheral blood stem cell sibling allografts for acute myeloid leukemia in first complete remission using fludarabine-cyclophosphamide reduced intensity conditioning.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(5):560-7.
2007: Kylie D Mason; Marina R Carpinelli; Jamie I Fletcher; Janelle E Collinge; Adrienne A Hilton; Sarah Ellis; Priscilla N Kelly; Paul G Ekert; Donald Metcalf; Andrew W Roberts; David C S Huang; Benjamin T Kile
Programmed anuclear cell death delimits platelet life span.
Cell 2007;128(6):1173-86.
2007: David S Ritchie; John F Seymour; Andrew P Grigg; Andrew W Roberts; R Hoyt; S Thompson; Jeff Szer; H Miles Prince
The hyper-CVAD-rituximab chemotherapy programme followed by high-dose busulfan, melphalan and autologous stem cell transplantation produces excellent event-free survival in patients with previously untreated mantle cell lymphoma.
Annals of hematology 2007;86(2):101-5.
2006: Mark F Van Delft; Andrew H Wei; Kylie D Mason; Cassandra J Vandenberg; Lin Chen; Peter Czabotar; Simon N Willis; Clare L Scott; Catherine L Day; Suzanne Cory; Jerry M Adams; Andrew W Roberts; David C S Huang
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
Cancer cell 2006;10(5):389-99.
2006: Warren S Alexander; Elizabeth M Viney; Jian-Guo Zhang; Donald Metcalf; Maria Kauppi; Craig D Hyland; Marina R Carpinelli; William Stevenson; Ben A Croker; Adrienne A Hilton; Sarah Ellis; Carly Selan; Harshal H Nandurkar; Christopher C Goodnow; Benjamin T Kile; Nicos A Nicola; Andrew W Roberts; Douglas J Hilton
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16442-7.
2006: Junya Kuroda; Hamsa Puthalakath; Mark Cragg; Priscilla N Kelly; Philippe Bouillet; David C S Huang; Shinya Kimura; Oliver G Ottmann; Brian J Druker; Andreas Villunger; Andrew W Roberts; Andreas Strasser
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14907-12.
2006: Jo L Eyles; Andrew W Roberts; Donald Metcalf; Ian P Wicks
Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease.
Nature clinical practice. Rheumatology 2006;2(9):500-10.
2006: William S Stevenson; Rosemary Hoyt; Anthony Bell; Michel Guipponi; Surender Juneja; Andrew P Grigg; David J Curtis; Hamish Scott; Jeff Szer; Warren S Alexander; Annabel Tuckfield; Andrew W Roberts
Genetic heterogeneity of granulocytes for the JAK2 V617F mutation in essential thrombocythaemia: implications for mutation detection in peripheral blood.
Pathology 2006;38(4):336-42.
2006: Peter K K Wong; Paul J Egan; Ben A Croker; Kristy O'Donnell; Natalie Sims; Sarah Drake; Hiu Kiu; Edward J McManus; Warren S Alexander; Andrew W Roberts; Ian P Wicks
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.
The Journal of clinical investigation 2006;116(6):1571-81.
2006: Ariel Forrai; Kristy Boyle; Adam H Hart; Lynne Hartley; Steven Rakar; Tracy A Willson; Ken M Simpson; Andrew W Roberts; Warren S Alexander; Anne K Voss; Lorraine Robb
Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells.
Stem cells (Dayton, Ohio) 2006;24(3):604-14.
2006: David P Steensma; Animesh Pardanani; William S Stevenson; Rosemary Hoyt; Hiu Kiu; Andrew P Grigg; Jeff Szer; Surender Juneja; Douglas J Hilton; Warren S Alexander; Andrew W Roberts
More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders.
Blood 2006;107(4):1733-5; author reply 1735.
2005: Lorraine Robb; Kristy Boyle; Steven Rakar; Lynne Hartley; Janelle Lochland; Andrew W Roberts; Warren S Alexander; Donald Metcalf
Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16333-8.
2005: Andrew W Roberts
G-CSF: a key regulator of neutrophil production, but that's not all!
Growth factors (Chur, Switzerland) 2005;23(1):33-41.
2004: Andrew P Grigg; M Brown; Andrew W Roberts; Jeff Szer; M A Slavin
A pilot study of targeted itraconazole prophylaxis in patients with graft-versus-host disease at high risk of invasive mould infections following allogeneic stem cell transplantation.
Bone marrow transplantation 2004;34(5):447-53.
2004: Kate E Lawlor; Ian K Campbell; Donald Metcalf; Kristy O'Donnell; Annemarie van Nieuwenhuijze; Andrew W Roberts; Ian P Wicks
Critical role for granulocyte colony-stimulating factor in inflammatory arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(31):11398-403.
2004: David S Ritchie; Andrew P Grigg; Andrew W Roberts; Mark A Rosenthal; Richard M Fox; Jeff Szer
Staged autologous peripheral blood progenitor cell transplantation for Ewing sarcoma and rhabdomyosarcoma.
Internal medicine journal 2004;34(7):431-4.
2004: Marina R Carpinelli; Douglas J Hilton; Donald Metcalf; Jennifer Antonchuk; Craig D Hyland; Sandra Mifsud; Ladina Di Rago; Adrienne A Hilton; Tracy A Willson; Andrew W Roberts; Robert G Ramsay; Nicos A Nicola; Warren S Alexander
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6553-8.
2004: Monica Slavin; Jeff Szer; Andrew P Grigg; Andrew W Roberts; John F Seymour; J Sasadeusz; Karin Thursky; S C Chen; Catherine Morrissey; C H Heath; T Sorrell
Guidelines for the use of antifungal agents in the treatment of invasive Candida and mould infections.
Internal medicine journal 2004;34(4):192-200.
2004: Ben A Croker; Donald Metcalf; Lorraine Robb; Wei Wei; Sandra Mifsud; Ladina DiRago; Leonie A Cluse; Kate D Sutherland; Lynne Hartley; Emily Williams; Jian-Guo Zhang; Douglas J Hilton; Nicos A Nicola; Warren S Alexander; Andrew W Roberts
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
Immunity 2004;20(2):153-65.
2003: David S Ritchie; James Morton; Jeff Szer; Andrew W Roberts; Simon Durrant; Peter Shuttleworth; Andrew P Grigg
Graft-versus-host disease, donor chimerism, and organ toxicity in stem cell transplantation after conditioning with fludarabine and melphalan.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2003;9(7):435-42.
2003: Ben A Croker; Danielle L Krebs; Jian-Guo Zhang; Samuel Wormald; Tracy A Willson; Edouard G Stanley; Lorraine Robb; Christopher J Greenhalgh; Irmgard Förster; Björn E Clausen; Nicos A Nicola; Donald Metcalf; Douglas J Hilton; Andrew W Roberts; Warren S Alexander
SOCS3 negatively regulates IL-6 signaling in vivo.
Nature immunology 2003;4(6):540-5.
2002: David S Ritchie; Jeff Szer; Andrew W Roberts; Peter Shuttleworth; Andrew P Grigg
A phase I dose-escalation study of etoposide continuous infusion added to busulphan/cyclophosphamide as conditioning prior to autologous or allogeneic stem cell transplantation.
Bone marrow transplantation 2002;30(10):645-50.
2002: Ben A Croker; Emanuela Handman; John D Hayball; Tracey M Baldwin; Valentina Voigt; Leonie A Cluse; Feng-Chun Yang; David A Williams; Andrew W Roberts
Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses.
Immunology and cell biology 2002;80(3):231-40.
2002: Ben A Croker; David M Tarlinton; Leonie A Cluse; Alana J Tuxen; Amanda Light; Feng-Chun Yang; David A Williams; Andrew W Roberts
The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3376-86.
2002: Monica Slavin; K Kannan; M R Buchanan; J Sasadeusz; Andrew W Roberts
Successful allogeneic stem cell transplant after invasive pulmonary zygomycosis.
Leukemia & lymphoma 2002;43(2):437-9.
2001: Andrew W Roberts; Lorraine Robb; Steven Rakar; Lynne Hartley; Leonie A Cluse; Nicos A Nicola; Donald Metcalf; Douglas J Hilton; Warren S Alexander
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9324-9.
2001: David S Ritchie; John F Seymour; Andrew W Roberts; Jeff Szer; Andrew P Grigg
Acute left ventricular failure following melphalan and fludarabine conditioning.
Bone marrow transplantation 2001;28(1):101-3.
2001: Feng-Chun Yang; Simon J Atkinson; Yi Gu; Jovencio Borneo; Andrew W Roberts; Y Zheng; J Pennington; David A Williams
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5614-8.
1999: Andrew W Roberts; Chaekyun Kim; Lijie Zhen; J B Lowe; Reuben Kapur; B Petryniak; A Spaetti; Jonathan D Pollock; Jovencio Borneo; G B Bradford; Simon J Atkinson; Mary C Dinauer; David A Williams
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.
Immunity 1999;10(2):183-96.
1997: Andrew W Roberts; Andrew P Grigg
Optimal regimens for the mobilization and collection of peripheral blood progenitor cells from normal donors.
Leukemia & lymphoma 1997;27(1-2):77-82.
1997: Andrew W Roberts; Simon J Foote; Warren S Alexander; C Scott; Lorraine Robb; Donald Metcalf
Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor.
Blood 1997;89(8):2736-44.
1996: Warren S Alexander; Andrew W Roberts; Nicos A Nicola; R Li; Donald Metcalf
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.
Blood 1996;87(6):2162-70.
1996: Donald Metcalf; Andrew W Roberts; Tracy A Willson
The regulation of hematopoiesis in max 41 transgenic mice with sustained excess granulopoiesis.
Leukemia 1996;10(2):311-20.
1996: Warren S Alexander; Andrew W Roberts; A B Maurer; Nicos A Nicola; Ashley R Dunn; Donald Metcalf
Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.
Stem cells (Dayton, Ohio) 1996;14 Suppl 1():124-32.
1995: A P Grigg; Andrew W Roberts; H Raunow; S Houghton; J E Layton; A W Boyd; K M McGrath; D Maher
Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers.
Blood 1995;86(12):4437-45.
1995: Andrew W Roberts; C Glenn Begley; A P Grigg; Russell L Basser
Do steady-state peripheral blood progenitor cell (PBPC) counts predict the yield of PBPC mobilized by filgrastim alone?
Blood 1995;86(6):2451.
1995: Andrew W Roberts; E DeLuca; C Glenn Begley; Russell L Basser; A P Grigg; Donald Metcalf
Broad inter-individual variations in circulating progenitor cell numbers induced by granulocyte colony-stimulating factor therapy.
Stem cells (Dayton, Ohio) 1995;13(5):512-6.
1994: J D Lickliter; Andrew W Roberts; A P Grigg
Phase II study of glycosylated recombinant human granulocyte colony-stimulating factor after HLA-identical sibling bone marrow transplantation.
Australian and New Zealand journal of medicine 1994;24(5):541-6.
1992: Andrew W Roberts; William Patrick Sheridan; A P Grigg
All-trans retinoic acid--chemotherapy interactions in acute promyelocytic leukaemia.
Australian and New Zealand journal of medicine 1992;22(6):704.