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Trevor Biden

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Jeng Yie Chan; Mohammed Bensellam; Trevor J Biden; Jude Luzuriaga; D Ross Laybutt
Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes.
J Y Chan; Trevor J Biden; D Ross Laybutt
Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets.
Ebru Boslem; Peter J Meikle; Trevor J Biden
Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction.

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All Publications

2013: Jeng Yie Chan; Mohammed Bensellam; Trevor J Biden; Jude Luzuriaga; D Ross Laybutt
Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes.
Diabetes 2013;62(5):1557-68.
2012: J Y Chan; Trevor J Biden; D Ross Laybutt
Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets.
Diabetologia 2012;55(11):2999-3009.
2012: Ebru Boslem; Peter J Meikle; Trevor J Biden
Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction.
Islets 2012;4(3):177-87.
2011: J Y Chan; Gregory J Cooney; Trevor J Biden; D R Laybutt
Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells.
Diabetologia 2011;54(7):1766-76.
2011: K Raddatz; N Turner; G Frangioudakis; B M Liao; D J Pedersen; J Cantley; D Wilks; E Preston; Bronwyn D Hegarty; M Leitges; M J Raftery; Trevor J Biden; Carsten Schmitz-Peiffer
Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice.
Diabetologia 2011;54(6):1447-56.
2011: Ebru Boslem; Gemma MacIntosh; Amanda M Preston; Clarissa Bartley; Anna K Busch; Maria Fuller; D Ross Laybutt; Peter J Meikle; Trevor J Biden
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.
The Biochemical journal 2011;435(1):267-76.
2011: J Cantley; Ebru Boslem; D R Laybutt; Damien Cordery; G Pearson; L Carpenter; M Leitges; Trevor J Biden
Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.
Diabetologia 2011;54(2):380-9.
2010: James Cantley; Trevor J Biden
Targeting triglyceride/fatty acid cycling in β-cells as a therapy for augmenting glucose-stimulated insulin secretion.
Islets 2010;2(2):127-9.
2010: Carsten Schmitz-Peiffer; Trevor J Biden
PKCdelta blues for the beta-cell.
Diabetes 2010;59(1):1-3.
2009: G Frangioudakis; James G Burchfield; S Narasimhan; Gregory J Cooney; Michael Leitges; Trevor J Biden; Carsten Schmitz-Peiffer
Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.
Diabetologia 2009;52(12):2616-20.
2009: A M Preston; Ebru Boslem; C Bartley; D Ross Laybutt; Trevor J Biden
Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.
Diabetologia 2009;52(11):2369-73.
2009: James Cantley; James G Burchfield; Gemma L Pearson; Carsten Schmitz-Peiffer; Michael Leitges; Trevor J Biden
Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells.
Diabetes 2009;58(8):1826-34.
2008: Mia Akerfeldt; Jennifer Howes; Jeng Yie Chan; Veronica A Stevens; Nacer Boubenna; Helen M McGuire; Cecile King; Trevor J Biden; D Ross Laybutt
Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.
Diabetes 2008;57(11):3034-44.
2008: Trevor J Biden; Carsten Schmitz-Peiffer; James G Burchfield; Ebru Boslem; James Cantley; Christopher J Mitchell; Lee Carpenter
The diverse roles of protein kinase C in pancreatic beta-cell function.
Biochemical Society transactions 2008;36(Pt 5):916-9.
2008: Carsten Schmitz-Peiffer; Trevor J Biden
Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes.
Diabetes 2008;57(7):1774-83.
2007: Caroline G Roberts; Ebru Boslem; Trevor J Biden; Robert L Sutherland; Alison J Butt
Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism.
Molecular cancer therapeutics 2007;6(10):2777-85.
2007: Carsten Schmitz-Peiffer; D Ross Laybutt; James G Burchfield; Ebru Boslem; Sakura Narasimhan; Christopher J Mitchell; David J Pedersen; Uschi Braun; Gregory J Cooney; Michael Leitges; Trevor J Biden
Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.
Cell metabolism 2007;6(4):320-8.
2007: R Cazzolli; Todd W Mitchell; James G Burchfield; D J Pedersen; Nigel Turner; Trevor J Biden; Carsten Schmitz-Peiffer
Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle.
Diabetologia 2007;50(8):1732-42.
2007: D Ross Laybutt; A M Preston; Mia Akerfeldt; James G Kench; Anna K Busch; Andrew V Biankin; Trevor J Biden
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes.
Diabetologia 2007;50(4):752-63.
2006: Russell I Ludowyke; Zehra Elgundi; Tanya Kranenburg; Justine R Stehn; Carsten Schmitz-Peiffer; William E Hughes; Trevor J Biden
Phosphorylation of nonmuscle myosin heavy chain IIA on Ser1917 is mediated by protein kinase C beta II and coincides with the onset of stimulated degranulation of RBL-2H3 mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1492-9.
2005: Anna K Busch; Ebru Boslem; Damien Cordery; Michelle Sudlow; Gareth S Denyer; D Ross Laybutt; William E Hughes; Trevor J Biden
Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.
Diabetes 2005;54(10):2917-24.
2005: Cecilie Kjørholt; Mia Akerfeldt; Trevor J Biden; D Ross Laybutt
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.
Diabetes 2005;54(9):2755-63.
2004: William E Hughes; Zehra Elgundi; Ping Huang; Michael A Frohman; Trevor J Biden
Phospholipase D1 regulates secretagogue-stimulated insulin release in pancreatic beta-cells.
The Journal of biological chemistry 2004;279(26):27534-41.
2004: James G Burchfield; Alecia J Lennard; Sakura Narasimhan; William E Hughes; Valerie Wasinger; Garry L Corthals; Tomohiko Okuda; Hisato Kondoh; Trevor J Biden; Carsten Schmitz-Peiffer
Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta.
The Journal of biological chemistry 2004;279(18):18623-32.
2004: Gregory J Cooney; Ruth J Lyons; A Jayne Crew; Thomas E Jensen; Juan Carlos Molero; Christopher J Mitchell; Trevor J Biden; Christopher J Ormandy; David E James; Roger J Daly
Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice.
The EMBO journal 2004;23(3):582-93.
2004: Trevor J Biden; Darren Robinson; Damien Cordery; William E Hughes; Anna K Busch
Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics.
Diabetes 2004;53 Suppl 1():S159-65.
2004: Lee Carpenter; Christopher J Mitchell; Zheng Z Xu; Philip Poronnik; Gerald W Both; Trevor J Biden
PKC alpha is activated but not required during glucose-induced insulin secretion from rat pancreatic islets.
Diabetes 2004;53(1):53-60.
2003: Elizabeth A Woodcock; Christopher J Mitchell; Trevor J Biden
Phospholipase Cdelta(1) does not mediate Ca(2+) responses in neonatal rat cardiomyocytes.
FEBS letters 2003;546(2-3):325-8.
2003: Angela A Matassa; R L Kalkofen; Lee Carpenter; Trevor J Biden; Mary E Reyland
Inhibition of PKCalpha induces a PKCdelta-dependent apoptotic program in salivary epithelial cells.
Cell death and differentiation 2003;10(3):269-77.
2002: R Cazzolli; D L Craig; Trevor J Biden; Carsten Schmitz-Peiffer
Inhibition of glycogen synthesis by fatty acid in C(2)C(12) muscle cells is independent of PKC-alpha, -epsilon, and -theta.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1204-13.
2002: Anna K Busch; Damien Cordery; Gareth S Denyer; Trevor J Biden
Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function.
Diabetes 2002;51(4):977-87.
2002: Lee Carpenter; Damien Cordery; Trevor J Biden
Inhibition of protein kinase C delta protects rat INS-1 cells against interleukin-1beta and streptozotocin-induced apoptosis.
Diabetes 2002;51(2):317-24.
2001: Jane F Arthur; Scot J Matkovich; Christopher J Mitchell; Trevor J Biden; Elizabeth A Woodcock
Evidence for selective coupling of alpha 1-adrenergic receptors to phospholipase C-beta 1 in rat neonatal cardiomyocytes.
The Journal of biological chemistry 2001;276(40):37341-6.
2001: Jean Buteau; Sylvain Foisy; C J Rhodes; Lee Carpenter; Trevor J Biden; Marc Prentki
Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
Diabetes 2001;50(10):2237-43.
2001: R Cazzolli; Lee Carpenter; Trevor J Biden; Carsten Schmitz-Peiffer
A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate.
Diabetes 2001;50(10):2210-8.
2001: Angela A Matassa; Lee Carpenter; Trevor J Biden; Michael J Humphries; Mary E Reyland
PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells.
The Journal of biological chemistry 2001;276(32):29719-28.
2001: Christopher J Mitchell; M M Kelly; M Blewitt; JR Wilson; Trevor J Biden
Phospholipase C-gamma mediates the hydrolysis of phosphatidylinositol, but not of phosphatidylinositol 4,5-bisphoshate, in carbamylcholine-stimulated islets of langerhans.
The Journal of biological chemistry 2001;276(22):19072-7.
2001: J R Wilson; Russell I Ludowyke; Trevor J Biden
A redistribution of actin and myosin IIA accompanies Ca(2+)-dependent insulin secretion.
FEBS letters 2001;492(1-2):101-6.
2001: Lee Carpenter; Damien Cordery; Trevor J Biden
Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells.
The Journal of biological chemistry 2001;276(7):5368-74.
2000: K S Bell; Carsten Schmitz-Peiffer; MY Lim-Fraser; Trevor J Biden; Gregory J Cooney; Edward W Kraegen
Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-theta localization.
American journal of physiology. Endocrinology and metabolism 2000;279(5):E1196-201.
2000: Stephen M Carlin; Philip Poronnik; David I Cook; Lee Carpenter; Trevor J Biden; Peter R A Johnson; Judith L Black
An antisense of protein kinase C-zeta inhibits proliferation of human airway smooth muscle cells.
American journal of respiratory cell and molecular biology 2000;23(4):555-9.
2000: T P Iismaa; E A Kerr; JR Wilson; Lee Carpenter; N Sims; Trevor J Biden
Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets.
Diabetes 2000;49(3):392-8.
1999: D Ross Laybutt; Carsten Schmitz-Peiffer; Asish K Saha; Neil B Ruderman; Trevor J Biden; Edward W Kraegen
Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat.
The American journal of physiology 1999;277(6 Pt 1):E1070-6.
1999: JR Wilson; Trevor J Biden; Russell I Ludowyke
Increases in phosphorylation of the myosin II heavy chain, but not regulatory light chains, correlate with insulin secretion in rat pancreatic islets and RINm5F cells.
Diabetes 1999;48(12):2383-9.
1999: Carsten Schmitz-Peiffer; D L Craig; Trevor J Biden
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate.
The Journal of biological chemistry 1999;274(34):24202-10.
1999: Lee Jamieson; Lee Carpenter; Trevor J Biden; Alan P Fields
Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis.
The Journal of biological chemistry 1999;274(7):3927-30.
1998: JR Wilson; Russell I Ludowyke; Trevor J Biden
Nutrient stimulation results in a rapid Ca2+-dependent threonine phosphorylation of myosin heavy chain in rat pancreatic islets and RINm5F cells.
The Journal of biological chemistry 1998;273(35):22729-37.
1998: Carsten Schmitz-Peiffer; CL Browne; J H Walker; Trevor J Biden
Activated protein kinase C alpha associates with annexin VI from skeletal muscle.
The Biochemical journal 1998;330 ( Pt 2)():675-81.
1998: Neil B Ruderman; Asish K Saha; D Vavvas; Theodore G Kurowski; D Ross Laybutt; Carsten Schmitz-Peiffer; Trevor J Biden; Edward W Kraegen
Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity.
Advances in experimental medicine and biology 1998;441():263-70.
1997: Carsten Schmitz-Peiffer; Nicholas D Oakes; CL Browne; Edward W Kraegen; Trevor J Biden
Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653.
The American journal of physiology 1997;273(5 Pt 1):E915-21.
1997: Carsten Schmitz-Peiffer; CL Browne; Nicholas D Oakes; AL Watkinson; Donald J Chisholm; Edward W Kraegen; Trevor J Biden
Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.
Diabetes 1997;46(2):169-78.
1996: Carsten Schmitz-Peiffer; C L Browne; Trevor J Biden
Characterization of two forms of protein kinase C alpha, with different substrate specificities, from skeletal muscle.
The Biochemical journal 1996;320 ( Pt 1)():207-14.
1995: L A Selbie; K Darby; Carsten Schmitz-Peiffer; C L Browne; Herbert Herzog; John Shine; Trevor J Biden
Synergistic interaction of Y1-neuropeptide Y and alpha 1b-adrenergic receptors in the regulation of phospholipase C, protein kinase C, and arachidonic acid production.
The Journal of biological chemistry 1995;270(20):11789-96.
1995: Michael B Morris; GB Ralston; Trevor J Biden; C L Browne; Glenn F King; T P Iismaa
Structural and biochemical studies of human galanin: NMR evidence for nascent helical structures in aqueous solution.
Biochemistry 1995;34(14):4538-45.
1994: John Shine; Erica K Potter; Trevor J Biden; L A Selbie; Herbert Herzog
Neuropeptide Y and regulation of the cardiovascular system.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1994;12(10):S41-5.
1993: L A Selbie; Carsten Schmitz-Peiffer; Y Sheng; Trevor J Biden
Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.
The Journal of biological chemistry 1993;268(32):24296-302.
1993: Trevor J Biden; C L Browne
Cross-talk between muscarinic- and adenosine-receptor signalling in the regulation of cytosolic free Ca2+ and insulin secretion.
The Biochemical journal 1993;293 ( Pt 3)():721-8.
1993: Trevor J Biden; A G Davison; M L Prugue
Regulation by membrane potential of phosphatidylinositol hydrolysis in pancreatic islets.
The Journal of biological chemistry 1993;268(15):11065-72.
1992: Trevor J Biden; M L Prugue; A G Davison
Evidence for phosphatidylinositol hydrolysis in pancreatic islets stimulated with carbamoylcholine. Kinetic analysis of inositol polyphosphate metabolism.
The Biochemical journal 1992;285 ( Pt 2)():541-9.
1992: G Hayes; Trevor J Biden; L A Selbie; John Shine
Structural subtypes of the dopamine D2 receptor are functionally distinct: expression of the cloned D2A and D2B subtypes in a heterologous cell line.
Molecular endocrinology (Baltimore, Md.) 1992;6(6):920-6.