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Charles Roberts

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Melanie A Jackson; Charles T Roberts; Nicholas Caputo; Jessica R Castle; Larry L David; W Kenneth Ward
Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas.
Jonathan Whittaker; Linda J Whittaker; Faramarz Ismail-Beigi; Michael C Lawrence; Nelson B Phillips; Charles T Roberts; Michael A Weiss
α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase.
Suman Malempati; Joel M Reid; Charles T Roberts; Stephen Schmechel; Stephan D Voss; Brenda Weigel; Julie M Carroll; Helen X Chen; Steve Y Cho; Ashish Ingle; Mark Krailo; Peter Charles Adamson; Charlotte H Ahern; Susan M Blaney
Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group.

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All Publications

2012: Melanie A Jackson; Charles T Roberts; Nicholas Caputo; Jessica R Castle; Larry L David; W Kenneth Ward
Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas.
Current diabetes reports 2012;12(6):705-10.
2012: Jonathan Whittaker; Linda J Whittaker; Faramarz Ismail-Beigi; Michael C Lawrence; Nelson B Phillips; Charles T Roberts; Michael A Weiss
α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(28):11166-71.
2012: Suman Malempati; Joel M Reid; Charles T Roberts; Stephen Schmechel; Stephan D Voss; Brenda Weigel; Julie M Carroll; Helen X Chen; Steve Y Cho; Ashish Ingle; Mark Krailo; Peter Charles Adamson; Charlotte H Ahern; Susan M Blaney
Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(3):256-62.
2011: R W O'Rourke; A E White; M D Metcalf; Antoinette Olivas; P Mitra; W G Larison; E C Cheang; Oleg Varlamov; C L Corless; Charles T Roberts; D L Marks
Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells.
Diabetologia 2011;54(6):1480-90.
2011: D L F Furness; Gustaaf A Dekker; Charles T Roberts
DNA damage and health in pregnancy.
Journal of reproductive immunology 2011;89(2):153-62.
2010: Lesley M E McCowan; Charles T Roberts; Gustaaf A Dekker; Rennae Taylor; E H Y Chan; L C Kenny; Philip N Baker; Rona Moss-Morris; L C Chappell; Robyn A North
Risk factors for small-for-gestational-age infants by customised birthweight centiles: data from an international prospective cohort study.
BJOG : an international journal of obstetrics and gynaecology 2010;117(13):1599-607.
2010: W Kenneth Ward; Ryan G Massoud; Cory J Szybala; Julia M Engle; Joseph El Youssef; Julie M Carroll; Charles T Roberts; Richard D Dimarchi
In vitro and in vivo evaluation of native glucagon and glucagon analog (MAR-D28) during aging: lack of cytotoxicity and preservation of hyperglycemic effect.
Journal of diabetes science and technology 2010;4(6):1311-21.
2010: Oleg Varlamov; Romel Somwar; Anda Cornea; Paul Kievit; Kevin L Grove; Charles T Roberts
Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes.
American journal of physiology. Endocrinology and metabolism 2010;299(3):E486-96.
2010: Youhei Sohma; Qing-xin Hua; Ming Liu; Nelson B Phillips; Shi-Quan Hu; Jonathan Whittaker; Linda J Whittaker; Aubree Ng; Charles T Roberts; Peter Arvan; Stephen B H Kent; Michael A Weiss
Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.
The Journal of biological chemistry 2010;285(7):5040-55.
2009: Robert W O'rourke; M D Metcalf; A E White; A Madala; B R Winters; I I Maizlin; Blair A Jobe; Charles T Roberts; Mark K Slifka; Daniel L Marks
Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue.
International journal of obesity (2005) 2009;33(9):978-90.
2009: Peng Fang; I. David Schwartz; Betty D Johnson; Michael A Derr; Charles T Roberts; Vivian Hwa; Ronald G Rosenfeld
Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay.
The Journal of clinical endocrinology and metabolism 2009;94(5):1740-7.
2009: Paturi V Rao; Ashok P Reddy; Xinfang Lu; Surendra Dasari; Adiraju Krishnaprasad; Evan Biggs; Charles T Roberts; Srinivasa R Nagalla
Proteomic identification of salivary biomarkers of type-2 diabetes.
Journal of proteome research 2009;8(1):239-45.
2008: Robert H Mak; Wai W Cheung; Charles T Roberts
The growth hormone-insulin-like growth factor-I axis in chronic kidney disease.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2008;18(1):17-25.
2007: David Le; Daniel L Marks; E Lyle; Christopher L Corless; Brian Diggs; Blair A Jobe; T Kay; Clifford W Deveney; Bruce M Wolfe; Charles T Roberts; Robert W O'rourke
Serum leptin levels, hepatic leptin receptor transcription, and clinical predictors of non-alcoholic steatohepatitis in obese bariatric surgery patients.
Surgical endoscopy 2007;21(9):1593-9.
2007: Adam Denley; Julie M Carroll; Gemma V Brierley; Leah J Cosgrove; John Wallace; Briony E Forbes; Charles T Roberts
Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors.
Molecular and cellular biology 2007;27(10):3569-77.
2007: John-Edward A Michaels; Surendra Dasari; Leonardo Pereira; Ashok Reddy; Jodi A Lapidus; Xinfang Lu; Thomas Jacob; Thomas Jacob; Matthew Rodland; Charles T Roberts; Michael G Gravett; Srinivasa R Nagalla
Comprehensive proteomic analysis of the human amniotic fluid proteome: gestational age-dependent changes.
Journal of proteome research 2007;6(4):1277-85.
2007: Leonardo Pereira; Ashok Reddy; Thomas Jacob; Thomas Jacob; Kimberly A Schneider; Surendra Dasari; Jodi A Lapidus; Xinfang Lu; Matthew Rodland; Charles T Roberts; Michael G Gravett; Srinivasa R Nagalla
Identification of novel protein biomarkers of preterm birth in human cervical-vaginal fluid.
Journal of proteome research 2007;6(4):1269-76.
2007: Surendra Dasari; Leonardo Pereira; Ashok Reddy; John-Edward A Michaels; Xinfang Lu; Thomas Jacob; Thomas Jacob; Matthew Rodland; Charles T Roberts; Michael G Gravett; Srinivasa R Nagalla
Comprehensive proteomic analysis of human cervical-vaginal fluid.
Journal of proteome research 2007;6(4):1258-68.
2007: Srinivasa R Nagalla; Jacob A Canick; Thomas Jacob; Kimberly A Schneider; Ashok Reddy; Thomas Jacob; Surendra Dasari; Xinfang Lu; Jodi A Lapidus; Geralyn M Lambert-Messerlian; Michael G Gravett; Charles T Roberts; David A Luthy; Fergal D Malone; Mary E D'alton
Proteomic analysis of maternal serum in down syndrome: identification of novel protein biomarkers.
Journal of proteome research 2007;6(4):1245-57.
2007: Patrick P Rose; Julie M Carroll; Patrick A Carroll; Victor DeFilippis; Michael Lagunoff; Ashlee V Moses; Charles T Roberts; Klaus J Frueh
The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma.
Oncogene 2007;26(14):1995-2005.
2007: Haim Werner; Gila Idelman; Moran Rubinstein; Patrick Pattee; Srinivasa R Nagalla; Charles T Roberts
A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene.
Cancer letters 2007;247(1):84-90.
2007: Paturi V Rao; Xinfang Lu; Melissa Standley; Patrick Pattee; Gundupalle Neelima; Gudige Girisesh; K V Dakshinamurthy; Charles T Roberts; Srinivasa R Nagalla
Proteomic identification of urinary biomarkers of diabetic nephropathy.
Diabetes care 2007;30(3):629-37.
2007: Sarah K Broughton; Hanqin Chen; Art Riddle; Scott E Kuhn; Srinivasa R Nagalla; Charles T Roberts; Stephen A Back
Large-scale generation of highly enriched neural stem-cell-derived oligodendroglial cultures: maturation-dependent differences in insulin-like growth factor-mediated signal transduction.
Journal of neurochemistry 2007;100(3):628-38.
2007: Michael G Gravett; Thomas Jacob; Kimberly A Schneider; Ashok Reddy; Surendra Dasari; Thomas Jacob; Xinfang Lu; Matthew Rodland; Leonardo Pereira; Drew W Sadowsky; Charles T Roberts; Miles J Novy; Srinivasa R Nagalla
Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection.
Journal of proteome research 2007;6(1):89-96.
2006: Robert W O'rourke; T Kay; E A Lyle; S A Traxler; Clifford W Deveney; Blair A Jobe; Charles T Roberts; Daniel L Marks; James T Rosenbaum
Alterations in peripheral blood lymphocyte cytokine expression in obesity.
Clinical and experimental immunology 2006;146(1):39-46.
2006: Adam Denley; Gemma V Brierley; Julie M Carroll; Anne Lindenberg; Grant W Booker; Leah J Cosgrove; John C Wallace; Briony E Forbes; Charles T Roberts
Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain.
Endocrinology 2006;147(2):1029-36.
2005: Stephen A Back; Ning Ling Luo; Rebecca A Mallinson; Jean P O'Malley; Linda D Wallen; Balz Frei; Jason D Morrow; Carol K Petito; Charles T Roberts; Geoffrey H Murdoch; Thomas J Montine
Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes.
Annals of neurology 2005;58(1):108-20.
2005: P V Rao; Xinfang Lu; Patrick Pattee; M Turner; Suguna Nandgaonkar; Bhanu T Paturi; Charles T Roberts; Srinivasa R Nagalla
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
The Journal of the Association of Physicians of India 2005;53():521-6.
2005: Giuseppe Pandini; Rossana Mineo; Francesco Frasca; Charles T Roberts; Marco Marcelli; Riccardo Vigneri; Antonino Belfiore
Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells.
Cancer research 2005;65(5):1849-57.
2004: Stephen R Plymate; Marie K Tennant; Stephen Hembree Culp; Lillie Woodke; Marco Marcelli; Ilsa Colman; Peter S Nelson; Julie M Carroll; Charles T Roberts; Joy L Ware
Androgen receptor (AR) expression in AR-negative prostate cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic tumors.
The Prostate 2004;61(3):276-90.
2004: Michael G Gravett; Miles J Novy; Ronald G Rosenfeld; Ashok Reddy; Thomas Jacob; Mark Turner; Ashley McCormack; Jodi A Lapidus; Jane Hitti; David A Eschenbach; Charles T Roberts; Srinivasa R Nagalla
Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers.
JAMA : the journal of the American Medical Association 2004;292(4):462-9.
2004: Teri L Wadsworth; Julie M Carroll; Rebecca A Mallinson; Charles T Roberts; Charles E Roselli
Saw palmetto extract suppresses insulin-like growth factor-I signaling and induces stress-activated protein kinase/c-Jun N-terminal kinase phosphorylation in human prostate epithelial cells.
Endocrinology 2004;145(7):3205-14.
2004: Anthony M Carter; FA Hills; D B O'Gorman; Charles T Roberts; Suren R Sooranna; C S Watson; Melissa Westwood
The insulin-like growth factor system in mammalian pregnancy--a workshop report.
Placenta 2004;25 Suppl A():S53-6.
2004: Charles T Roberts
IGF-1 and prostate cancer.
Novartis Foundation symposium 2004;262():193-9; discussion 199-204, 265-8.
2003: Nathan Airhart; Yong-Feng Yang; Charles T Roberts; Michael Silberbach
Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction.
The Journal of biological chemistry 2003;278(40):38693-8.
2003: Derek LeRoith; Charles T Roberts
The insulin-like growth factor system and cancer.
Cancer letters 2003;195(2):127-37.
2003: Lara Longobardi; Monica Torello; Caroline Buckway; Lynda O'Rear; William A Horton; Vivian Hwa; Charles T Roberts; Francesco Chiarelli; Ronald G Rosenfeld; Anna Spagnoli
A novel insulin-like growth factor (IGF)-independent role for IGF binding protein-3 in mesenchymal chondroprogenitor cell apoptosis.
Endocrinology 2003;144(5):1695-702.
2003: Sumeet S Chugh; Stacey Whitesel; Mark Turner; Charles T Roberts; Srinivasa R Nagalla
Genetic basis for chamber-specific ventricular phenotypes in the rat infarct model.
Cardiovascular research 2003;57(2):477-85.
2003: Haim Werner; Charles T Roberts
The IGFI receptor gene: a molecular target for disrupted transcription factors.
Genes, chromosomes & cancer 2003;36(2):113-20.
2003: Gila Idelman; Tova Glaser; Charles T Roberts; Haim Werner
WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation.
The Journal of biological chemistry 2003;278(5):3474-82.
2002: Anna Spagnoli; Monica Torello; Srinivasa R Nagalla; William A Horton; Patrick Pattee; Vivian Hwa; Francesco Chiarelli; Charles T Roberts; Ronald G Rosenfeld
Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis.
The Journal of biological chemistry 2002;277(21):18860-7.
2002: Ina Finkeltov; Scott Kuhn; Tova Glaser; Gila Idelman; John J Wright; Charles T Roberts; Haim Werner
Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein.
Oncogene 2002;21(12):1890-8.
2001: Michael Silberbach; Charles T Roberts
Natriuretic peptide signalling: molecular and cellular pathways to growth regulation.
Cellular signalling 2001;13(4):221-31.
2001: Anna Spagnoli; Vivian Hwa; William A Horton; Gregory P Lunstrum; Charles T Roberts; Francesco Chiarelli; Monica Torello; Ronald G Rosenfeld
Antiproliferative effects of insulin-like growth factor-binding protein-3 in mesenchymal chondrogenic cell line RCJ3.1C5.18. relationship to differentiation stage.
The Journal of biological chemistry 2001;276(8):5533-40.
2001: SE Damon; Stephen R Plymate; Julie M Carroll; Cynthia C Sprenger; Chavaboon Dechsukhum; Joy L Ware; Charles T Roberts
Transcriptional regulation of insulin-like growth factor-I receptor gene expression in prostate cancer cells.
Endocrinology 2001;142(1):21-7.
2000: Charles T Roberts
Insulin-like growth factor I receptor regulation in prostate carcinoma.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2000;10 Suppl A():S20-1.
2000: Hisanori Kato; Y Okubo; Y Matsumura; Charles T Roberts; K Sugahara; D LeRoith
The tyrosine kinase activity of the chicken insulin receptor is similar to that of the human insulin receptor.
Bioscience, biotechnology, and biochemistry 2000;64(4):903-6.
1999: K Tajinda; J Carroll; Charles T Roberts
Regulation of insulin-like growth factor I receptor promoter activity by wild-type and mutant versions of the WT1 tumor suppressor.
Endocrinology 1999;140(10):4713-24.
1999: Michael Silberbach; T Gorenc; Ray E Hershberger; Philip J S Stork; Peter S Steyger; Charles T Roberts
Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes.
The Journal of biological chemistry 1999;274(35):24858-64.
1998: DY Moromisato; Charles T Roberts; JA Brasel; S Mohan; E Cowles; S M King; Dan M Cooper
Erythrocyte insulin-like growth factor-L binding in younger and older males.
Clinical endocrinology 1998;48(3):339-45.
1998: AP Koval; VA Blakesley; Charles T Roberts; Y Zick; Derek LeRoith
Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor.
The Biochemical journal 1998;330 ( Pt 2)():923-32.
1998: D Landau; H Domene; A Flyvbjerg; H Grønbaek; Charles T Roberts; S Argov; Derek LeRoith
Differential expression of renal growth hormone receptor and its binding protein in experimental diabetes mellitus.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1998;8(1):39-45.
1997: H S Kim; Srinivasa R Nagalla; Youngman Oh; Elizabeth M Wilson; Charles T Roberts; Ronald G Rosenfeld
Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):12981-6.
1997: A Eliakim; M Moromisato; DY Moromisato; JA Brasel; Charles T Roberts; Dan M Cooper
Increase in muscle IGF-I protein but not IGF-I mRNA after 5 days of endurance training in young rats.
The American journal of physiology 1997;273(4 Pt 2):R1557-61.
1997: Gary B Silberstein; Katharine Van Horn; Phyllis Strickland; Charles T Roberts; Charles W Daniel
Altered expression of the WT1 wilms tumor suppressor gene in human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8132-7.
1997: G Dong; R Rajah; T Vu; A R Hoffman; Ronald G Rosenfeld; Charles T Roberts; D M Peehl; Pinchas Cohen
Decreased expression of Wilms' tumor gene WT-1 and elevated expression of insulin growth factor-II (IGF-II) and type 1 IGF receptor genes in prostatic stromal cells from patients with benign prostatic hyperplasia.
The Journal of clinical endocrinology and metabolism 1997;82(7):2198-203.
1997: C Hernández-Sánchez; H Werner; Charles T Roberts; E J Woo; D W Hum; Stephen M Rosenthal; Derek LeRoith
Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor.
The Journal of biological chemistry 1997;272(8):4663-70.
1996: Charles T Roberts
Control of insulin-like growth factor (IGF) action by regulation of IGF-I receptor expression.
Endocrine journal 1996;43 Suppl():S49-55.
1996: Y Matsumura; M Domeki; K Sugahara; T Kubo; Charles T Roberts; D LeRoith; H Kato
Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens.
Bioscience, biotechnology, and biochemistry 1996;60(6):979-82.
1996: D Y Moromisato; M Y Moromisato; S Zanconato; Charles T Roberts
Effect of hypoxia on lung, heart, and liver insulin-like growth factor-I gene and receptor expression in the newborn rat.
Critical care medicine 1996;24(6):919-24.
1996: S Neuenschwander; A Schwartz; T L Wood; Charles T Roberts; L Hennighausen; Derek LeRoith
Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.
The Journal of clinical investigation 1996;97(10):2225-32.
1996: Keren Paz; H Voliovitch; Y R Hadari; Charles T Roberts; Derek LeRoith; Yehiel Zick
Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis.
The Journal of biological chemistry 1996;271(12):6998-7003.
1996: D Kleinman; M Karas; Michael Danilenko; A Arbell; Charles T Roberts; D LeRoith; Joseph Levy; Yoav Sharoni
Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins.
Endocrinology 1996;137(3):1089-95.
1996: A A Butler; B Funk; Bernhard H Breier; D LeRoith; Charles T Roberts; Peter D Gluckman
Growth hormone (GH) status regulates GH receptor and GH binding protein mRNA in a tissue- and transcript-specific manner but has no effect on insulin-like growth factor-I receptor mRNA in the rat.
Molecular and cellular endocrinology 1996;116(2):181-9.
1996: VA Blakesley; Thea Kalebic; Lee Helman; Bethel Stannard; T N Faria; Charles T Roberts; Derek LeRoith
Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.
Endocrinology 1996;137(2):410-7.
1996: H Werner; Charles T Roberts; Frank J Rauscher; Derek LeRoith
Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1.
Journal of molecular neuroscience : MN 1996;7(2):111-23.
1995: Bethel Stannard; VA Blakesley; H Kato; Charles T Roberts; Derek LeRoith
Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis.
Endocrinology 1995;136(11):4918-24.
1995: H Yang; Martin Adamo; AP Koval; M C McGuinness; H Ben-Hur; Y Yang; Derek LeRoith; Charles T Roberts
Alternative leader sequences in insulin-like growth factor I mRNAs modulate translational efficiency and encode multiple signal peptides.
Molecular endocrinology (Baltimore, Md.) 1995;9(10):1380-95.
1995: Stephanie Edmondson; George Werther; A Russell; D LeRoith; Charles T Roberts; F Beck
Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: relationship to insulin-like growth factor-I mRNA.
Endocrinology 1995;136(10):4602-9.
1995: S Neuenschwander; Charles T Roberts; Derek LeRoith
Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid.
Endocrinology 1995;136(10):4298-303.
1995: D Beitner-Johnson; H Werner; Charles T Roberts; Derek LeRoith
Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element.
Molecular endocrinology (Baltimore, Md.) 1995;9(9):1147-56.
1995: H Werner; Z Shen-Orr; Frank J Rauscher; J F Morris; Charles T Roberts; Derek LeRoith
Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression.
Molecular and cellular biology 1995;15(7):3516-22.
1995: D Kleinman; M Karas; Charles T Roberts; D LeRoith; Moshe Phillip; Y Segev; Joseph Levy; Yoav Sharoni
Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol.
Endocrinology 1995;136(6):2531-7.
1995: Eva Surmacz; C Sell; J Swantek; H Kato; Charles T Roberts; D LeRoith; Renato Baserga
Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor.
Experimental cell research 1995;218(1):370-80.
1995: Gad Potashnik; Eitan Lunenfeld; I Shwartz; Marek Glezerman; Charles T Roberts; D LeRoith; Yoav Sharoni; J Levy
Endogenous plasma growth hormone and the occurrence of pregnancies in patients undergoing in-vitro fertilization and embryo transfer with ovarian stimulation.
Human reproduction (Oxford, England) 1995;10(5):1065-9.
1995: D Landau; Edward Chin; Carolyn A Bondy; H Domene; Charles T Roberts; Henning Gronbaek; Allan Flyvbjerg; Derek LeRoith
Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes.
Endocrinology 1995;136(5):1835-42.
1995: S Malozowski; T G Parmer; S Trojan; G R Merriam; Geula Gibori; Charles T Roberts; Derek LeRoith; H Werner; Moshe Zilberstein
Growth hormone (GH) modulates insulin-like growth factor I (IGF-I) and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats.
European journal of endocrinology / European Federation of Endocrine Societies 1995;132(4):497-501.
1995: Derek LeRoith; H Werner; D Beitner-Johnson; Charles T Roberts
Molecular and cellular aspects of the insulin-like growth factor I receptor.
Endocrine reviews 1995;16(2):143-63.
1995: H M Domené; Fernando Cassorla; H Werner; Charles T Roberts; Derek LeRoith
Rat growth hormone receptor/growth hormone-binding protein mRNAs with divergent 5'-untranslated regions are expressed in a tissue-specific manner.
DNA and cell biology 1995;14(3):195-204.
1995: VA Blakesley; H Kato; Charles T Roberts; Derek LeRoith
Mutation of a conserved amino acid residue (tryptophan 1173) in the tyrosine kinase domain of the IGF-I receptor abolishes autophosphorylation but does not eliminate biologic function.
The Journal of biological chemistry 1995;270(6):2764-9.
1995: M Karas; D Kleinman; Michael Danilenko; Charles T Roberts; D LeRoith; Joseph Levy; Yoav Sharoni
Components of the IGF system mediate the opposing effects of tamoxifen on endometrial and breast cancer cell growth.
Progress in growth factor research 1995;6(2-4):513-20.
1995: J M Pash; Anne M Delany; Martin Adamo; Charles T Roberts; D LeRoith; Ernesto Canalis
Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells.
Endocrinology 1995;136(1):33-8.
1995: Derek LeRoith; R Baserga; Lee Helman; Charles T Roberts
Insulin-like growth factors and cancer.
Annals of internal medicine 1995;122(1):54-9.
1994: AP Koval; V Kulik; SJ Duguay; E Plisetskaya; Martin Adamo; Charles T Roberts; Derek LeRoith; Vadym Kavsan
Characterization of a salmon insulin-like growth factor I promoter.
DNA and cell biology 1994;13(10):1057-62.
1994: Ramkumar Menon; Dietrich A Stephan; R H Rao; Z Shen-Orr; L S Downs; Charles T Roberts; D LeRoith; Mark A Sperling
Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat.
The Journal of endocrinology 1994;142(3):453-62.
1994: H M Domené; R Meidan; S Yakar; Z Shen-Orr; Fernando Cassorla; Charles T Roberts; Derek LeRoith
Role of GH and IGF-I in the regulation of IGF-I, IGF-I receptor and IGF binding protein gene expression in the rat spleen.
Regulatory peptides 1994;52(3):215-26.
1994: Daniel David Bikle; J Harris; B P Halloran; Charles T Roberts; Derek LeRoith; E Morey-Holton
Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth.
The American journal of physiology 1994;267(2 Pt 1):E278-86.
1994: S Yakar; H Domene; R Meidan; Fernando Cassorla; I Gilad; I Koch; Z Laron; Charles T Roberts; Derek LeRoith; R Eshet
Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-binding protein (IGFBP)-2 gene expression in spleens of juvenile rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1994;26(8):363-6.
1994: CC Mastick; H Kato; Charles T Roberts; D LeRoith; Alan Saltiel
Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation.
Endocrinology 1994;135(1):214-22.
1994: A el-Roeiy; X Chen; VJ Roberts; S Shimasakai; N Ling; D LeRoith; Charles T Roberts; Samuel S C Yen
Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries.
The Journal of clinical endocrinology and metabolism 1994;78(6):1488-96.
1994: T N Faria; VA Blakesley; H Kato; Bethel Stannard; Derek LeRoith; Charles T Roberts
Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function.
The Journal of biological chemistry 1994;269(19):13922-8.
1994: A A Butler; G R Ambler; Bernhard H Breier; D LeRoith; Charles T Roberts; Peter D Gluckman
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment of the GH-deficient dwarf rat: differential effects on IGF-I transcription start site expression in hepatic and extrahepatic tissues and lack of effect on type I IGF receptor mRNA expression.
Molecular and cellular endocrinology 1994;101(1-2):321-30.
1994: S Zanconato; D Y Moromisato; M Y Moromisato; J Woods; JA Brasel; D Leroith; Charles T Roberts; Dan M Cooper
Effect of training and growth hormone suppression on insulin-like growth factor I mRNA in young rats.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(5):2204-9.
1994: Vadym Kavsan; V A Grebenjuk; AP Koval; A S Skorokhod; Charles T Roberts; Derek LeRoith
Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome.
DNA and cell biology 1994;13(5):555-9.
1994: H Werner; Frank J Rauscher; Vikas P Sukhatme; I A Drummond; Charles T Roberts; Derek LeRoith
Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site.
The Journal of biological chemistry 1994;269(17):12577-82.
1994: Michele Rubini; H Werner; E Gandini; Charles T Roberts; D LeRoith; Renato Baserga
Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene.
Experimental cell research 1994;211(2):374-9.
1994: M Phillip; H Werner; T Palese; A A Kowarski; B Stannard; L A Bach; D LeRoith; Charles T Roberts
Differential accumulation of insulin-like growth factor-I in kidneys of pre- and postpubertal streptozotocin-diabetic rats.
Journal of molecular endocrinology 1994;12(2):215-24.
1994: O Nadiv; Meir Shinitzky; H Manu; D Hecht; Charles T Roberts; Derek LeRoith; Yehiel Zick
Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats.
The Biochemical journal 1994;298 ( Pt 2)():443-50.
1994: Ayad A Jaffa; D LeRoith; Charles T Roberts; P F Rust; Ronald Mayfield
Insulin-like growth factor I produces renal hyperfiltration by a kinin-mediated mechanism.
The American journal of physiology 1994;266(1 Pt 2):F102-7.
1994: Derek LeRoith; P C Sampson; Charles T Roberts
How does the mitogenic insulin-like growth factor I receptor differ from the metabolic insulin receptor?
Hormone research 1994;41 Suppl 2():74-8; discussion 79.
1994: H Werner; Martin Adamo; Charles T Roberts; Derek LeRoith
Molecular and cellular aspects of insulin-like growth factor action.
Vitamins and hormones 1994;48():1-58.
1994: H Kato; T N Faria; Bethel Stannard; Charles T Roberts; Derek LeRoith
Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.
Molecular endocrinology (Baltimore, Md.) 1994;8(1):40-50.
1994: J C Chen; Zhi-min Shao; M S Sheikh; Arif Hussain; D LeRoith; Charles T Roberts; Joseph A Fontana
Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line.
Journal of cellular physiology 1994;158(1):69-78.
1993: Derek LeRoith; H Werner; M Phillip; Charles T Roberts
The role of insulin-like growth factors in diabetic kidney disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1993;22(5):722-6.
1993: Y R Hadari; Benjamin Geiger; O Nadiv; I Sabanay; Charles T Roberts; Derek LeRoith; Yehiel Zick
Hepatic tyrosine-phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: effects of H2O2 and vanadate administration into rat livers.
Molecular and cellular endocrinology 1993;97(1-2):9-17.
1993: A el-Roeiy; X Chen; VJ Roberts; D LeRoith; Charles T Roberts; Samuel S C Yen
Expression of insulin-like growth factor-I (IGF-I) and IGF-II and the IGF-I, IGF-II, and insulin receptor genes and localization of the gene products in the human ovary.
The Journal of clinical endocrinology and metabolism 1993;77(5):1411-8.
1993: J Shemer; A Yaron; H Werner; Zhi-min Shao; M S Sheikh; Joseph A Fontana; Derek LeRoith; Charles T Roberts
Regulation of insulin-like growth factor (IGF) binding protein-5 in the T47D human breast carcinoma cell line by IGF-I and retinoic acid.
The Journal of clinical endocrinology and metabolism 1993;77(5):1246-50.
1993: D Kleinman; Charles T Roberts; D LeRoith; Andrew V Schally; Joseph Levy; Yoav Sharoni
Regulation of endometrial cancer cell growth by insulin-like growth factors and the luteinizing hormone-releasing hormone antagonist SB-75.
Regulatory peptides 1993;48(1-2):91-8.
1993: E Hershkovitz; M Marbach; E Bosin; Joseph Levy; Charles T Roberts; D LeRoith; Andrew V Schally; Yoav Sharoni
Luteinizing hormone-releasing hormone antagonists interfere with autocrine and paracrine growth stimulation of MCF-7 mammary cancer cells by insulin-like growth factors.
The Journal of clinical endocrinology and metabolism 1993;77(4):963-8.
1993: Vadym Kavsan; AP Koval; V A Grebenjuk; S J Chan; D F Steiner; Charles T Roberts; Derek LeRoith
Structure of the chum salmon insulin-like growth factor I gene.
DNA and cell biology 1993;12(8):729-37.
1993: Derek LeRoith; Charles T Roberts
Insulin-like growth factors.
Annals of the New York Academy of Sciences 1993;692():1-9.
1993: Derek LeRoith; H Werner; T N Faria; H Kato; Martin Adamo; Charles T Roberts
Insulin-like growth factor receptors. Implications for nervous system function.
Annals of the New York Academy of Sciences 1993;692():22-32.
1993: Martin Adamo; J Shemer; Charles T Roberts; Derek LeRoith
Insulin and insulin-like growth factor-I induced phosphorylation in neurally derived cells.
Annals of the New York Academy of Sciences 1993;692():113-25.
1993: A Ferber; C Chang; C Sell; A Ptasznik; Vincent J Cristofalo; Karen Hubbard; Harvey L Ozer; Martin Adamo; Charles T Roberts; D LeRoith
Failure of senescent human fibroblasts to express the insulin-like growth factor-1 gene.
The Journal of biological chemistry 1993;268(24):17883-8.
1993: Derek LeRoith; Vadym Kavsan; AP Koval; Charles T Roberts
Phylogeny of the insulin-like growth factors (IGFs) and receptors: a molecular approach.
Molecular reproduction and development 1993;35(4):332-6; discussion 337-8.
1993: H Domené; K Krishnamurthi; R Eshet; I Gilad; Z Laron; I Koch; Bethel Stannard; Fernando Cassorla; Charles T Roberts; Derek LeRoith
Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-I-binding protein-3, but not GH receptor gene expression in livers of juvenile rats.
Endocrinology 1993;133(2):675-82.
1993: Derek LeRoith; Charles T Roberts
Insulin-like growth factors and their receptors in normal physiology and pathological states.
The Journal of pediatric endocrinology 1993;6(3-4):251-5.
1993: H Kato; T N Faria; Bethel Stannard; R Levy-Toledano; Simeon I Taylor; Charles T Roberts; Derek LeRoith
Paradoxical biological effects of overexpressed insulin-like growth factor-1 receptors in Chinese hamster ovary cells.
Journal of cellular physiology 1993;156(1):145-52.
1993: M S Sheikh; Zhi-min Shao; Arif Hussain; J C Chen; Charles T Roberts; D LeRoith; Joseph A Fontana
Retinoic acid and estrogen modulation of insulin-like growth factor binding protein-4 gene expression and the estrogen receptor status of human breast carcinoma cells.
Biochemical and biophysical research communications 1993;193(3):1232-8.
1993: H Werner; Gian G Re; I A Drummond; Vikas P Sukhatme; Frank J Rauscher; Donald A Sens; A Julian Garvin; Derek LeRoith; Charles T Roberts
Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5828-32.
1993: L F Botero; Charles T Roberts; D LeRoith; Eli Y Adashi; E R Hernandez
Insulin-like growth factor I gene expression by primary cultures of ovarian cells: insulin and dexamethasone dependence.
Endocrinology 1993;132(6):2703-8.
1993: M Woloschak; Z Shen-Orr; Derek LeRoith; Charles T Roberts
Nutritional regulation of insulin-sensitive glucose transporter gene expression in rat cardiac muscle.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;203(2):172-4.
1993: M S Sheikh; Zhi-min Shao; Arif Hussain; David R Clemmons; J C Chen; Charles T Roberts; D LeRoith; Joseph A Fontana
Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5, and 6: synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells.
Journal of cellular physiology 1993;155(3):556-67.
1993: R Eshet; H Werner; B Klinger; Aviva Silbergeld; Zvi Laron; D LeRoith; Charles T Roberts
Up-regulation of insulin-like growth factor-I (IGF-I) receptor gene expression in patients with reduced serum IGF-I levels.
Journal of molecular endocrinology 1993;10(2):115-20.
1993: Vadym Kavsan; AP Koval; O Petrenko; Charles T Roberts; Derek LeRoith
Two insulin genes are present in the salmon genome.
Biochemical and biophysical research communications 1993;191(3):1373-8.
1993: Derek LeRoith; Martin Adamo; J Shemer; F Lanau; Z Shen-Orr; A Yaron; Charles T Roberts; David R Clemmons; M S Sheikh; Zhi-min Shao
Retinoic acid inhibits growth of breast cancer cell lines: the role of insulin-like growth factor binding proteins.
Growth regulation 1993;3(1):78-80.
1993: H Kato; T N Faria; Bethel Stannard; Charles T Roberts; Derek LeRoith
Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).
The Journal of biological chemistry 1993;268(4):2655-61.
1993: Martin Adamo; F Lanau; S Neuenschwander; H Werner; Derek LeRoith; Charles T Roberts
Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells.
Endocrinology 1993;132(2):935-7.
1993: H Werner; Charles T Roberts; Derek LeRoith
The regulation of IGF-I receptor gene expression by positive and negative zinc-finger transcription factors.
Advances in experimental medicine and biology 1993;343():91-103.
1993: Martin Adamo; S Neuenschwander; D LeRoith; Charles T Roberts
Structure, expression, and regulation of the IGF-I gene.
Advances in experimental medicine and biology 1993;343():1-11.
1992: J Shemer; Martin Adamo; Charles T Roberts; Derek LeRoith
Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: evidence for differential regulation in the developing kidney.
Endocrinology 1992;131(6):2793-9.
1992: M S Sheikh; Zhi-min Shao; J C Chen; David R Clemmons; Charles T Roberts; D LeRoith; Joseph A Fontana
Insulin-like growth factor binding protein-5 gene expression is differentially regulated at a post-transcriptional level in retinoic acid-sensitive and resistant MCF-7 human breast carcinoma cells.
Biochemical and biophysical research communications 1992;188(3):1122-30.
1992: P Porcu; A Ferber; Z Pietrzkowski; Charles T Roberts; Martin Adamo; D LeRoith; Renato Baserga
The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor.
Molecular and cellular biology 1992;12(11):5069-77.
1992: H L Foyt; F Lanau; M Woloschak; Derek LeRoith; Charles T Roberts
Effect of growth hormone on levels of differentially processed insulin-like growth factor I mRNAs in total and polysomal mRNA populations.
Molecular endocrinology (Baltimore, Md.) 1992;6(11):1881-8.
1992: H Werner; M A Bach; Bethel Stannard; Charles T Roberts; Derek LeRoith
Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1545-58.
1992: Martin Adamo; Zhi-min Shao; F Lanau; J C Chen; David R Clemmons; Charles T Roberts; Derek LeRoith; Joseph A Fontana
Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line.
Endocrinology 1992;131(4):1858-66.
1992: Zhi-min Shao; M S Sheikh; J V Ordonez; Pei Feng; Timothy E Kute; J C Chen; Seena Aisner; Lauren Schnaper; D LeRoith; Charles T Roberts
IGFBP-3 gene expression and estrogen receptor status in human breast carcinoma.
Cancer research 1992;52(18):5100-3.
1992: Y R Hadari; E Tzahar; O Nadiv; P Rothenberg; Charles T Roberts; Derek LeRoith; Yosef Yarden; Yehiel Zick
Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.
The Journal of biological chemistry 1992;267(25):17483-6.
1992: M J Levy; E R Hernandez; Eli Y Adashi; R J Stillman; Charles T Roberts; Derek LeRoith
Expression of the insulin-like growth factor (IGF)-I and -II and the IGF-I and -II receptor genes during postnatal development of the rat ovary.
Endocrinology 1992;131(3):1202-6.
1992: Derek LeRoith; M McGuinness; J Shemer; Bethel Stannard; F Lanau; T N Faria; H Kato; H Werner; Martin Adamo; Charles T Roberts
Insulin-like growth factors.
Biological signals 1992;1(4):173-81.
1992: R C Eastman; Richard E Carson; D G Orloff; C S Cochran; J F Perdue; Matthew M Rechler; F Lanau; Charles T Roberts; J Shapiro; J Roth
Glucose utilization in a patient with hepatoma and hypoglycemia. Assessment by a positron emission tomography.
The Journal of clinical investigation 1992;89(6):1958-63.
1992: M M Sklar; C L Thomas; G Municchi; Charles T Roberts; Derek LeRoith; Wieland Kiess; Peter Nissley
Developmental expression of rat insulin-like growth factor-II/mannose 6-phosphate receptor messenger ribonucleic acid.
Endocrinology 1992;130(6):3484-91.
1992: M Phillip; T Palese; E R Hernandez; Charles T Roberts; D LeRoith; A A Kowarski
Effect of testosterone on insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the hypophysectomized rat.
Endocrinology 1992;130(5):2865-70.
1992: Susan E Mulroney; Michael D Lumpkin; Charles T Roberts; D LeRoith; Aviad Haramati
Effect of a growth hormone-releasing factor antagonist on compensatory renal growth, insulin-like growth factor-I (IGF-I), and IGF-I receptor gene expression after unilateral nephrectomy in immature rats.
Endocrinology 1992;130(5):2697-702.
1992: M S Sheikh; Zhi-min Shao; David R Clemmons; D LeRoith; Charles T Roberts; Joseph A Fontana
Identification of the insulin-like growth factor binding proteins 5 and 6 (IGFBP-5 and 6) in human breast cancer cells.
Biochemical and biophysical research communications 1992;183(3):1003-10.
1992: Eli Y Adashi; Carol E Resnick; A Hurwitz; E Ricciarellie; E R Hernandez; Charles T Roberts; D Leroith; Ronald G Rosenfeld
The intra-ovarian IGF system.
Growth regulation 1992;2(1):10-5.
1992: E R Hernandez; A Hurwitz; A Vera; A Pellicer; Eli Y Adashi; D LeRoith; Charles T Roberts
Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary.
The Journal of clinical endocrinology and metabolism 1992;74(2):419-25.
1992: Martin Adamo; Charles T Roberts; Derek LeRoith
How distinct are the insulin and insulin-like growth factor I signalling systems?
BioFactors (Oxford, England) 1992;3(3):151-7.
1992: Carolyn A Bondy; H Werner; Charles T Roberts; Derek LeRoith
Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II.
Neuroscience 1992;46(4):909-23.
1992: Susan E Mulroney; Aviad Haramati; H Werner; C Bondy; Charles T Roberts; D LeRoith
Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats.
Endocrinology 1992;130(1):249-56.
1992: Derek LeRoith; J Shemer; Charles T Roberts
Evolutionary origins of intercellular communication systems: implications for mammalian biology.
Hormone research 1992;38 Suppl 2():1-6.
1992: Derek LeRoith; H Werner; B Burguera; Charles T Roberts; Susan E Mulroney; A Haramati
The insulin-like growth factor family of peptides, binding proteins and receptors: their potential role in tissue regeneration.
Advances in experimental medicine and biology 1992;321():21-8; discussion 29-30.
1991: E R Hernandez; A Hurwitz; L Botero; E Ricciarelli; H Werner; Charles T Roberts; D LeRoith; Eli Y Adashi
Insulin-like growth factor receptor gene expression in the rat ovary: divergent regulation of distinct receptor species.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):1799-805.
1991: T G Parmer; Charles T Roberts; Derek LeRoith; Eli Y Adashi; Mohammad I Khan; N Solan; S Nelson; Moshe Zilberstein; Geula Gibori
Expression, action, and steroidal regulation of insulin-like growth factor-I (IGF-I) and IGF-I receptor in the rat corpus luteum: their differential role in the two cell populations forming the corpus luteum.
Endocrinology 1991;129(6):2924-32.
1991: Martin Adamo; H Ben-Hur; Charles T Roberts; Derek LeRoith
Regulation of start site usage in the leader exons of the rat insulin-like growth factor-I gene by development, fasting, and diabetes.
Molecular endocrinology (Baltimore, Md.) 1991;5(11):1677-86.
1991: Eli Y Adashi; Carol E Resnick; A Hurwitz; E Ricciarelli; E R Hernandez; Charles T Roberts; D Leroith; Ronald G Rosenfeld
Insulin-like growth factors: the ovarian connection.
Human reproduction (Oxford, England) 1991;6(9):1213-9.
1991: David W Cooke; L A Bankert; Charles T Roberts; D LeRoith; S J Casella
Analysis of the human type I insulin-like growth factor receptor promoter region.
Biochemical and biophysical research communications 1991;177(3):1113-20.
1991: E Jansen; Paul H Steenbergh; D LeRoith; Charles T Roberts; John S Sussenbach
Identification of multiple transcription start sites in the human insulin-like growth factor-I gene.
Molecular and cellular endocrinology 1991;78(1-2):115-25.
1991: Susan E Mulroney; Aviad Haramati; Charles T Roberts; D LeRoith
Renal IGF-1 mRNA levels are enhanced following unilateral nephrectomy in immature but not adult rats.
Endocrinology 1991;128(5):2660-2.
1991: B A Masters; H Werner; Charles T Roberts; D LeRoith; Mohan K Raizada
Developmental regulation of insulin-like growth factor-I-stimulated glucose transporter in rat brain astrocytes.
Endocrinology 1991;128(5):2548-57.
1991: D LeRoith; Charles T Roberts
Insulin-like growth factor I (IGF-I): a molecular basis for endocrine versus local action?
Molecular and cellular endocrinology 1991;77(1-3):C57-61.
1991: Martin Adamo; H Ben-Hur; Derek LeRoith; Charles T Roberts
Transcription initiation in the two leader exons of the rat IGF-I gene occurs from disperse versus localized sites.
Biochemical and biophysical research communications 1991;176(2):887-93.
1991: B A Masters; H Werner; Charles T Roberts; D LeRoith; Mohan K Raizada
Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains.
Regulatory peptides 1991;33(2):117-31.
1991: H L Foyt; Derek LeRoith; Charles T Roberts
Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo.
The Journal of biological chemistry 1991;266(11):7300-5.
1991: M A Bach; Z Shen-Orr; W L Lowe; Charles T Roberts; Derek LeRoith
Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain.
Brain research. Molecular brain research 1991;10(1):43-8.
1991: T L Wood; michael berelowitz; Marie C Gelato; Charles T Roberts; D LeRoith; W J Millard; J F McKelvy
Hormonal regulation of rat hypothalamic neuropeptide mRNAs: effect of hypophysectomy and hormone replacement on growth-hormone-releasing factor, somatostatin and the insulin-like growth factors.
Neuroendocrinology 1991;53(3):298-305.
1991: Eli Y Adashi; Carol E Resnick; E R Hernandez; A Hurwitz; Charles T Roberts; D Leroith; Ronald G Rosenfeld
Insulin-like growth factor I as an intraovarian regulator: basic and clinical implications.
Annals of the New York Academy of Sciences 1991;626():161-8.
1991: H Werner; Bethel Stannard; M A Bach; Charles T Roberts; Derek LeRoith
Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states.
Advances in experimental medicine and biology 1991;293():263-72.
1990: E R Hernandez; Charles T Roberts; A Hurwitz; D LeRoith; Eli Y Adashi
Rat ovarian insulin-like growth factor II gene expression is theca-interstitial cell-exclusive: hormonal regulation and receptor distribution.
Endocrinology 1990;127(6):3249-51.
1990: H Werner; Z Shen-Orr; Bethel Stannard; B Burguera; Charles T Roberts; Derek LeRoith
Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney.
Diabetes 1990;39(12):1490-7.
1990: Charles T Roberts; S N McCutcheon; H T Blair; Peter D Gluckman; Bernhard H Breier
Developmental patterns of plasma insulin-like growth factor-1 concentrations in sheep.
Domestic animal endocrinology 1990;7(4):457-63.
1990: B Burguera; H Werner; M Sklar; Z Shen-Orr; Bethel Stannard; Charles T Roberts; S P Nissley; Stephen J Vore; JF Caro; Derek LeRoith
Liver regeneration is associated with increased expression of the insulin-like growth factor-II/mannose-6-phosphate receptor.
Molecular endocrinology (Baltimore, Md.) 1990;4(10):1539-45.
1990: J Serrano; Alan R Shuldiner; Charles T Roberts; Derek LeRoith; Flora de Pablo
The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis.
Endocrinology 1990;127(3):1547-9.
1990: Carolyn A Bondy; H Werner; Charles T Roberts; Derek LeRoith
Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression.
Molecular endocrinology (Baltimore, Md.) 1990;4(9):1386-98.
1990: H Werner; Bethel Stannard; M A Bach; Derek LeRoith; Charles T Roberts
Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene.
Biochemical and biophysical research communications 1990;169(3):1021-7.
1990: M A Bach; Charles T Roberts; E P Smith; Derek LeRoith
Alternative splicing produces messenger RNAs encoding insulin-like growth factor-I prohormones that are differentially glycosylated in vitro.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):899-904.
1990: L M Mudd; H Werner; Z Shen-Orr; Charles T Roberts; D LeRoith; H C Haspel; Mohan K Raizada
Regulation of rat brain/HepG2 glucose transporter gene expression by phorbol esters in primary cultures of neuronal and astrocytic glial cells.
Endocrinology 1990;126(1):545-9.
1990: John-Olov Jansson; L Carlsson; S Ekberg; Jörgen Isgaard; Björn Carlsson; Hakan Billig; D Leroith; Charles T Roberts; Martin Adamo; M Woloschak
Pulsatile growth hormone secretory pattern: autofeedback regulation and effects on growth factors.
Acta paediatrica Scandinavica. Supplement 1990;367():98-102.
1989: W L Lowe; Charles T Roberts; Derek LeRoith; M T Rojeski; T J Merimee; S T Fui; H Keen; D Arnold; JAMES MERSEY; S Gluzman
Insulin-like growth factor-II in nonislet cell tumors associated with hypoglycemia: increased levels of messenger ribonucleic acid.
The Journal of clinical endocrinology and metabolism 1989;69(6):1153-9.
1989: H Werner; M Woloschak; Martin Adamo; Z Shen-Orr; Charles T Roberts; Derek LeRoith
Developmental regulation of the rat insulin-like growth factor I receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7451-5.
1989: Moshe Zilberstein; Janice Yang Chou; W L Lowe; Z Shen-Orr; Charles T Roberts; Derek LeRoith; Kevin J Catt
Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(9):1488-97.
1989: W L Lowe; Martin Adamo; Derek LeRoith; Charles T Roberts
Expression and stability of insulin-like growth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line.
Biochemical and biophysical research communications 1989;162(3):1174-9.
1989: W L Lowe; Martin Adamo; H Werner; Charles T Roberts; Derek LeRoith
Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding.
The Journal of clinical investigation 1989;84(2):619-26.
1989: A Ota; Z Shen-Orr; Charles T Roberts; Derek LeRoith
TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding.
Brain research. Molecular brain research 1989;6(1):69-76.
1989: E R Hernandez; Charles T Roberts; D LeRoith; Eli Y Adashi
Rat ovarian insulin-like growth factor I (IGF-I) gene expression is granulosa cell-selective: 5'-untranslated mRNA variant representation and hormonal regulation.
Endocrinology 1989;125(1):572-4.
1989: H Werner; M K Raizada; L M Mudd; H L Foyt; Ian A Simpson; Charles T Roberts; Derek LeRoith
Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells.
Endocrinology 1989;125(1):314-20.
1989: Alan R Shuldiner; S Phillips; Charles T Roberts; Derek LeRoith; J Roth
Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective.
The Journal of biological chemistry 1989;264(16):9428-32.
1989: Martin Adamo; W L Lowe; Derek LeRoith; Charles T Roberts
Insulin-like growth factor I messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed during development of the rat.
Endocrinology 1989;124(6):2737-44.
1989: Cecilia Bucci; P Mallucci; Charles T Roberts; R Frunzio; Carmelo B Bruni
Nucleotide sequence of a genomic fragment of the rat IGF-I gene spanning an alternate 5' non coding exon.
Nucleic acids research 1989;17(9):3596.
1989: James A Fagin; Charles T Roberts; D LeRoith; A T Brown
Coordinate decrease of tissue insulinlike growth factor I posttranscriptional alternative mRNA transcripts in diabetes mellitus.
Diabetes 1989;38(4):428-34.
1989: H Werner; Martin Adamo; W L Lowe; Charles T Roberts; Derek LeRoith
Developmental regulation of rat brain/Hep G2 glucose transporter gene expression.
Molecular endocrinology (Baltimore, Md.) 1989;3(2):273-9.
1988: Charles T Roberts; D Leroith
Molecular aspects of insulin-like growth factors, their binding proteins and receptors.
Baillière's clinical endocrinology and metabolism 1988;2(4):1069-85.
1988: Martin Adamo; H Werner; W Farnsworth; Charles T Roberts; M Raizada; Derek LeRoith
Dexamethasone reduces steady state insulin-like growth factor I messenger ribonucleic acid levels in rat neuronal and glial cells in primary culture.
Endocrinology 1988;123(5):2565-70.
1988: W L Lowe; S R Lasky; Derek LeRoith; Charles T Roberts
Distribution and regulation of rat insulin-like growth factor I messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: evidence for differential processing and regulation in liver.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):528-35.
1988: K Ojamaa; J A Hedo; Charles T Roberts; V Y Moncada; P Gorden; A Ullrich; Simeon I Taylor
Defects in human insulin receptor gene expression.
Molecular endocrinology (Baltimore, Md.) 1988;2(3):242-7.
1987: W L Lowe; Charles T Roberts; S R Lasky; Derek LeRoith
Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8946-50.
1987: Charles T Roberts; S R Lasky; W L Lowe; Derek LeRoith
Rat IGF-I cDNA's contain multiple 5'-untranslated regions.
Biochemical and biophysical research communications 1987;146(3):1154-9.
1987: Charles T Roberts; S R Lasky; W L Lowe; W T Seaman; Derek LeRoith
Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues.
Molecular endocrinology (Baltimore, Md.) 1987;1(3):243-8.
1987: W L Lowe; A E Schaffner; Charles T Roberts; Derek LeRoith
Developmental regulation of somatostatin gene expression in the brain is region specific.
Molecular endocrinology (Baltimore, Md.) 1987;1(2):181-7.
1986: Charles T Roberts; A L Brown; D E Graham; S Seelig; S Berry; K H Gabbay; Matthew M Rechler
Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver.
The Journal of biological chemistry 1986;261(22):10025-8.
1986: Derek LeRoith; G Delahunty; G L Wilson; Charles T Roberts; J Shemer; C Hart; M A Lesniak; J Shiloach; J Roth
Evolutionary aspects of the endocrine and nervous systems.
Recent progress in hormone research 1986;42():549-87.
1982: Joel Edward Lavine; Charles T Roberts; D E Morse
Glucose regulation of specific gene expression is altered in a glucokinase-deficient mutant of Tetrahymena.
Molecular and cellular biochemistry 1982;48(1):48-58.
1982: J E Lavine; E Cantlay; Charles T Roberts; D E Morse
Purification and properties of galactokinase from Tetrahymena thermophila.
Biochimica et biophysica acta 1982;717(1):76-85.
1982: Charles T Roberts; Joel Edward Lavine; D E Morse
Selection and characterization of a glucokinase-deficient mutant of Tetrahymena thermophila.
Molecular and cellular biology 1982;2(4):378-85.
1980: Charles T Roberts; D E Morse
Galactokinase-deficient mutants of Tetrahymena thermophila: selection and characterization.
Molecular & general genetics : MGG 1980;180(1):129-34.
1978: Charles T Roberts; D E Morse
Genetic regulation of galactokinase in Tetrahymena by cyclic AMP glucose, and epinephrine.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(4):1810-4.
1974: Charles T Roberts; E Orias
On the mechanism of adaptation to protein synthesis inhibitors by Tetrahymena. Facilitation, cross adaptation, and resensitization.
The Journal of cell biology 1974;62(3):707-16.