Charles Roberts

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O'Rourke R W; Metcalf M D; White A E; Madala A; Winters B R; Maizlin I I; Jobe B A; Roberts C T; Slifka M K; Marks D L
Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue.
Fang Peng; Schwartz I David; Johnson Betty D; Derr Michael A; Roberts Charles T; Hwa Vivian; Rosenfeld Ron G
Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay.
Rao Paturi V; Reddy Ashok P; Lu Xinfang; Dasari Surendra; Krishnaprasad Adiraju; Biggs Evan; Roberts Charles T; Nagalla Srinivasa R
Proteomic identification of salivary biomarkers of type-2 diabetes.

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All Publications

2009: O'Rourke R W; Metcalf M D; White A E; Madala A; Winters B R; Maizlin I I; Jobe B A; Roberts C T; Slifka M K; Marks D L
Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue.
International journal of obesity (2005) 2009;33(9):978-90.
2009: Fang Peng; Schwartz I David; Johnson Betty D; Derr Michael A; Roberts Charles T; Hwa Vivian; Rosenfeld Ron G
Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay.
The Journal of clinical endocrinology and metabolism 2009;94(5):1740-7.
2009: Rao Paturi V; Reddy Ashok P; Lu Xinfang; Dasari Surendra; Krishnaprasad Adiraju; Biggs Evan; Roberts Charles T; Nagalla Srinivasa R
Proteomic identification of salivary biomarkers of type-2 diabetes.
Journal of proteome research 2009;8(1):239-45.
2008: Mak Robert H; Cheung Wai W; Roberts Charles T
The growth hormone-insulin-like growth factor-I axis in chronic kidney disease.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2008;18(1):17-25.
2007: Le D; Marks D; Lyle E; Corless C L; Diggs B S; Jobe B A; Kay T; Deveney C W; Wolfe B M; Roberts C T; O'Rourke R W
Serum leptin levels, hepatic leptin receptor transcription, and clinical predictors of non-alcoholic steatohepatitis in obese bariatric surgery patients.
Surgical endoscopy 2007;21(9):1593-9.
2007: Denley Adam; Carroll Julie M; Brierley Gemma V; Cosgrove Leah; Wallace John; Forbes Briony; Roberts Charles T
Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors.
Molecular and cellular biology 2007;27(10):3569-77.
2007: Michaels John-Edward A; Dasari Surendra; Pereira Leonardo; Reddy Ashok P; Lapidus Jodi A; Lu Xinfang; Jacob Thomas; Thomas Archana; Rodland Matthew; Roberts Charles T; Gravett Michael G; Nagalla Srinivasa R
Comprehensive proteomic analysis of the human amniotic fluid proteome: gestational age-dependent changes.
Journal of proteome research 2007;6(4):1277-85.
2007: Pereira Leonardo; Reddy Ashok P; Jacob Thomas; Thomas Archana; Schneider Kimberly A; Dasari Surendra; Lapidus Jodi A; Lu Xinfang; Rodland Matthew; Roberts Charles T; Gravett Michael G; Nagalla Srinivasa R
Identification of novel protein biomarkers of preterm birth in human cervical-vaginal fluid.
Journal of proteome research 2007;6(4):1269-76.
2007: Dasari Surendra; Pereira Leonardo; Reddy Ashok P; Michaels John-Edward A; Lu Xinfang; Jacob Thomas; Thomas Archana; Rodland Matthew; Roberts Charles T; Gravett Michael G; Nagalla Srinivasa R
Comprehensive proteomic analysis of human cervical-vaginal fluid.
Journal of proteome research 2007;6(4):1258-68.
2007: Nagalla Srinivasa R; Canick Jacob A; Jacob Thomas; Schneider Kimberly A; Reddy Ashok P; Thomas Archana; Dasari Surendra; Lu Xinfang; Lapidus Jodi A; Lambert-Messerlian Geralyn M; Gravett Michael G; Roberts Charles T; Luthy David; Malone Fergal D; D'Alton Mary E
Proteomic analysis of maternal serum in down syndrome: identification of novel protein biomarkers.
Journal of proteome research 2007;6(4):1245-57.
2007: Rao Paturi V; Lu Xinfang; Standley Melissa; Pattee Patrick; Neelima Gundupalle; Girisesh Gudige; Dakshinamurthy K V; Roberts Charles T; Nagalla Srinivasa R
Proteomic identification of urinary biomarkers of diabetic nephropathy.
Diabetes care 2007;30(3):629-37.
2007: Rose P P; Carroll J M; Carroll P A; DeFilippis V R; Lagunoff M; Moses A V; Roberts C T; Früh K
The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma.
Oncogene 2007;26(14):1995-2005.
2007: Werner Haim; Idelman Gila; Rubinstein Moran; Pattee Patrick; Nagalla Srinivasa R; Roberts Charles T
A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene.
Cancer letters 2007;247(1):84-90.
2007: Broughton Sarah K; Chen Hanqin; Riddle Art; Kuhn Scott E; Nagalla Srinivasa; Roberts Charles T; Back Stephen A
Large-scale generation of highly enriched neural stem-cell-derived oligodendroglial cultures: maturation-dependent differences in insulin-like growth factor-mediated signal transduction.
Journal of neurochemistry 2007;100(3):628-38.
2007: Gravett Michael G; Thomas Archana; Schneider Kimberly A; Reddy Ashok P; Dasari Surendra; Jacob Thomas; Lu Xinfang; Rodland Matthew; Pereira Leonardo; Sadowsky Drew W; Roberts Charles T; Novy Miles J; Nagalla Srinivasa R
Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection.
Journal of proteome research 2007;6(1):89-96.
2006: O'Rourke R W; Kay T; Lyle E A; Traxler S A; Deveney C W; Jobe B A; Roberts C T; Marks D; Rosenbaum J T
Alterations in peripheral blood lymphocyte cytokine expression in obesity.
Clinical and experimental immunology 2006;146(1):39-46.
2006: Denley Adam; Brierley Gemma V; Carroll Julie M; Lindenberg Anne; Booker Grant W; Cosgrove Leah J; Wallace John C; Forbes Briony E; Roberts Charles T
Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain.
Endocrinology 2006;147(2):1029-36.
2005: Back Stephen A; Luo Ning Ling; Mallinson Rebecca A; O'Malley Jean P; Wallen Linda D; Frei Balz; Morrow Jason D; Petito Carol K; Roberts Charles T; Murdoch Geoffrey H; Montine Thomas J
Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes.
Annals of neurology 2005;58(1):108-20.
2005: Rao P V; Lu X; Pattee P; Turner M; Nandgaonkar Suguna; Paturi Bhanu T; Roberts C T; Nagalla S R
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
The Journal of the Association of Physicians of India 2005;53():521-6.
2005: MacLaughlin S M; Walker S K; Roberts C T; Kleemann D O; McMillen I C
Periconceptional nutrition and the relationship between maternal body weight changes in the periconceptional period and feto-placental growth in the sheep.
The Journal of physiology 2005;565(Pt 1):111-24.
2005: Mühlhäusler B S; Adam C L; Marrocco E M; Findlay P A; Roberts C T; McFarlane J R; Kauter K G; McMillen I C
Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation.
The Journal of physiology 2005;565(Pt 1):185-95.
2005: Pandini Giuseppe; Mineo Rossana; Frasca Francesco; Roberts Charles T; Marcelli Marco; Vigneri Riccardo; Belfiore Antonino
Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells.
Cancer research 2005;65(5):1849-57.
2004: Plymate Stephen R; Tennant Marie K; Culp Stephen H; Woodke Lillie; Marcelli Marco; Colman Ilsa; Nelson Peter S; Carroll Julie M; Roberts Charles T; Ware Joy L
Androgen receptor (AR) expression in AR-negative prostate cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic tumors.
The Prostate 2004;61(3):276-90.
2004: Gravett Michael G; Novy Miles J; Rosenfeld Ron G; Reddy Ashok P; Jacob Thomas; Turner Mark; McCormack Ashley; Lapidus Jodi A; Hitti Jane; Eschenbach David A; Roberts Charles T; Nagalla Srinivasa R
Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers.
JAMA : the journal of the American Medical Association 2004;292(4):462-9.
2004: Wadsworth Teri L; Carroll Julie M; Mallinson Rebecca A; Roberts Charles T; Roselli Charles E
Saw palmetto extract suppresses insulin-like growth factor-I signaling and induces stress-activated protein kinase/c-Jun N-terminal kinase phosphorylation in human prostate epithelial cells.
Endocrinology 2004;145(7):3205-14.
2004: Carter A M; Hills F; O'Gorman D B; Roberts C T; Sooranna S R; Watson C S; Westwood M
The insulin-like growth factor system in mammalian pregnancy--a workshop report.
Placenta 2004;25 Suppl A():S53-6.
2004: Roberts Charles T
IGF-1 and prostate cancer.
Novartis Foundation symposium 2004;262():193-9; discussion 199-204, 265-8.
2003: Mühlhäusler B S; Roberts C T; Yuen B S J; Marrocco E; Budge H; Symonds M E; McFarlane J R; Kauter K G; Stagg P; Pearse J K; McMillen I C
Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy.
Endocrinology 2003;144(11):4947-54.
2003: Airhart Nathan; Yang Yong-Feng; Roberts Charles T; Silberbach Michael
Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction.
The Journal of biological chemistry 2003;278(40):38693-8.
2003: LeRoith Derek; Roberts Charles T
The insulin-like growth factor system and cancer.
Cancer letters 2003;195(2):127-37.
2003: Yuen B S J; Owens P C; Muhlhausler B S; Roberts C T; Symonds M E; Keisler D H; McFarlane J R; Kauter K G; Evens Y; McMillen I C
Leptin alters the structural and functional characteristics of adipose tissue before birth.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1102-4.
2003: Longobardi Lara; Torello Monica; Buckway Caroline; O'Rear Lynda; Horton William A; Hwa Vivian; Roberts Charles T; Chiarelli Francesco; Rosenfeld Ron G; Spagnoli Anna
A novel insulin-like growth factor (IGF)-independent role for IGF binding protein-3 in mesenchymal chondroprogenitor cell apoptosis.
Endocrinology 2003;144(5):1695-702.
2003: Chugh Sumeet S; Whitesel Stacey; Turner Mark; Roberts Charles T; Nagalla Srinivasa R
Genetic basis for chamber-specific ventricular phenotypes in the rat infarct model.
Cardiovascular research 2003;57(2):477-85.
2003: Werner Haim; Roberts Charles T
The IGFI receptor gene: a molecular target for disrupted transcription factors.
Genes, chromosomes & cancer 2003;36(2):113-20.
2003: Idelman Gila; Glaser Tova; Roberts Charles T; Werner Haim
WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation.
The Journal of biological chemistry 2003;278(5):3474-82.
2002: Mühlhäusler B S; Roberts C T; McFarlane J R; Kauter K G; McMillen I C
Fetal leptin is a signal of fat mass independent of maternal nutrition in ewes fed at or above maintenance energy requirements.
Biology of reproduction 2002;67(2):493-9.
2002: Spagnoli Anna; Torello Monica; Nagalla Srivinasa R; Horton William A; Pattee Patrick; Hwa Vivian; Chiarelli Francesco; Roberts Charles T; Rosenfeld Ron G
Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis.
The Journal of biological chemistry 2002;277(21):18860-7.
2002: Finkeltov Ina; Kuhn Scott; Glaser Tova; Idelman Gila; Wright John J; Roberts Charles T; Werner Haim
Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein.
Oncogene 2002;21(12):1890-8.
2001: Silberbach M; Roberts C T
Natriuretic peptide signalling: molecular and cellular pathways to growth regulation.
Cellular signalling 2001;13(4):221-31.
2001: Spagnoli A; Hwa V; Horton W A; Lunstrum G P; Roberts C T; Chiarelli F; Torello M; Rosenfeld R G
Antiproliferative effects of insulin-like growth factor-binding protein-3 in mesenchymal chondrogenic cell line RCJ3.1C5.18. relationship to differentiation stage.
The Journal of biological chemistry 2001;276(8):5533-40.
2001: Damon S E; Plymate S R; Carroll J M; Sprenger C C; Dechsukhum C; Ware J L; Roberts C T
Transcriptional regulation of insulin-like growth factor-I receptor gene expression in prostate cancer cells.
Endocrinology 2001;142(1):21-7.
2000: Roberts C T
Insulin-like growth factor I receptor regulation in prostate carcinoma.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2000;10 Suppl A():S20-1.
2000: Kato H; Okubo Y; Matsumura Y; Roberts C T; Sugahara K; LeRoith D
The tyrosine kinase activity of the chicken insulin receptor is similar to that of the human insulin receptor.
Bioscience, biotechnology, and biochemistry 2000;64(4):903-6.
1999: Tajinda K; Carroll J; Roberts C T
Regulation of insulin-like growth factor I receptor promoter activity by wild-type and mutant versions of the WT1 tumor suppressor.
Endocrinology 1999;140(10):4713-24.
1999: Silberbach M; Gorenc T; Hershberger R E; Stork P J; Steyger P S; Roberts C T
Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes.
The Journal of biological chemistry 1999;274(35):24858-64.
1999: Robertson S A; Roberts C T; Farr K L; Dunn A R; Seamark R F
Fertility impairment in granulocyte-macrophage colony-stimulating factor-deficient mice.
Biology of reproduction 1999;60(2):251-61.
1998: Koval A P; Blakesley V A; Roberts C T; Zick Y; Leroith D
Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor.
The Biochemical journal 1998;330 ( Pt 2)():923-32.
1998: Landau D; Domene H; Flyvbjerg A; Grønbaek H; Roberts C T; Argov S; LeRoith D
Differential expression of renal growth hormone receptor and its binding protein in experimental diabetes mellitus.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1998;8(1):39-45.
1997: Kim H S; Nagalla S R; Oh Y; Wilson E; Roberts C T; Rosenfeld R G
Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):12981-6.
1997: Wood P G; Andrew L K; Daniels C B; Orgeig S; Roberts C T
Autonomic control of the pulmonary surfactant system and lung compliance in the lizard.
Physiological zoology 1997;70(4):444-55.
1997: Silberstein G B; Van Horn K; Strickland P; Roberts C T; Daniel C W
Altered expression of the WT1 wilms tumor suppressor gene in human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8132-7.
1997: Dong G; Rajah R; Vu T; Hoffman A R; Rosenfeld R G; Roberts C T; Peehl D M; Cohen P
Decreased expression of Wilms' tumor gene WT-1 and elevated expression of insulin growth factor-II (IGF-II) and type 1 IGF receptor genes in prostatic stromal cells from patients with benign prostatic hyperplasia.
The Journal of clinical endocrinology and metabolism 1997;82(7):2198-203.
1997: Hernández-Sánchez C; Werner H; Roberts C T; Woo E J; Hum D W; Rosenthal S M; LeRoith D
Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor.
The Journal of biological chemistry 1997;272(8):4663-70.
1996: Roberts C T
Control of insulin-like growth factor (IGF) action by regulation of IGF-I receptor expression.
Endocrine journal 1996;43 Suppl():S49-55.
1996: Matsumura Y; Domeki M; Sugahara K; Kubo T; Roberts C T; LeRoith D; Kato H
Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens.
Bioscience, biotechnology, and biochemistry 1996;60(6):979-82.
1996: Moromisato D Y; Moromisato M Y; Zanconato S; Roberts C T
Effect of hypoxia on lung, heart, and liver insulin-like growth factor-I gene and receptor expression in the newborn rat.
Critical care medicine 1996;24(6):919-24.
1996: Neuenschwander S; Schwartz A; Wood T L; Roberts C T; Hennighausen L; LeRoith D
Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.
The Journal of clinical investigation 1996;97(10):2225-32.
1996: Roberts C T; Breed W G
The marsupial shell membrane: an ultrastructural and immunogold localization study.
Cell and tissue research 1996;284(1):99-110.
1996: Paz K; Voliovitch H; Hadari Y R; Roberts C T; LeRoith D; Zick Y
Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis.
The Journal of biological chemistry 1996;271(12):6998-7003.
1996: Kleinman D; Karas M; Danilenko M; Arbell A; Roberts C T; LeRoith D; Levy J; Sharoni Y
Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins.
Endocrinology 1996;137(3):1089-95.
1996: Butler A A; Funk B; Breier B H; LeRoith D; Roberts C T; Gluckman P D
Growth hormone (GH) status regulates GH receptor and GH binding protein mRNA in a tissue- and transcript-specific manner but has no effect on insulin-like growth factor-I receptor mRNA in the rat.
Molecular and cellular endocrinology 1996;116(2):181-9.
1996: Blakesley V A; Kalebic T; Helman L J; Stannard B; Faria T N; Roberts C T; LeRoith D
Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.
Endocrinology 1996;137(2):410-7.
1996: Werner H; Roberts C T; Rauscher F J; LeRoith D
Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1.
Journal of molecular neuroscience : MN 1996;7(2):111-23.
1996: Roberts C T; Breed W G
Changes in structure of the trophectoderm of a marsupial in Mid-pregnancy up to the time of implantation.
Reproduction, fertility, and development 1996;8(4):797-802.
1996: Roberts C T; Breed W G
Variation in ultrastructure of mucoid coat and shell membrane secretion of a dasyurid marsupial.
Reproduction, fertility, and development 1996;8(4):645-8.
1995: Stannard B; Blakesley V; Kato H; Roberts C T; LeRoith D
Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis.
Endocrinology 1995;136(11):4918-24.
1995: Yang H; Adamo M L; Koval A P; McGuinness M C; Ben-Hur H; Yang Y; LeRoith D; Roberts C T
Alternative leader sequences in insulin-like growth factor I mRNAs modulate translational efficiency and encode multiple signal peptides.
Molecular endocrinology (Baltimore, Md.) 1995;9(10):1380-95.
1995: Edmondson S R; Werther G A; Russell A; LeRoith D; Roberts C T; Beck F
Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: relationship to insulin-like growth factor-I mRNA.
Endocrinology 1995;136(10):4602-9.
1995: Neuenschwander S; Roberts C T; LeRoith D
Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid.
Endocrinology 1995;136(10):4298-303.
1995: Beitner-Johnson D; Werner H; Roberts C T; LeRoith D
Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element.
Molecular endocrinology (Baltimore, Md.) 1995;9(9):1147-56.
1995: Werner H; Shen-Orr Z; Rauscher F J; Morris J F; Roberts C T; LeRoith D
Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression.
Molecular and cellular biology 1995;15(7):3516-22.
1995: Kleinman D; Karas M; Roberts C T; LeRoith D; Phillip M; Segev Y; Levy J; Sharoni Y
Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol.
Endocrinology 1995;136(6):2531-7.
1995: Surmacz E; Sell C; Swantek J; Kato H; Roberts C T; LeRoith D; Baserga R
Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor.
Experimental cell research 1995;218(1):370-80.
1995: Potashnik G; Lunenfeld E; Shwartz I; Glezerman M; Roberts C T; LeRoith D; Sharoni Y; Levy J
Endogenous plasma growth hormone and the occurrence of pregnancies in patients undergoing in-vitro fertilization and embryo transfer with ovarian stimulation.
Human reproduction (Oxford, England) 1995;10(5):1065-9.
1995: Landau D; Chin E; Bondy C; Domene H; Roberts C T; Gronbaek H; Flyvbjerg A; LeRoith D
Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes.
Endocrinology 1995;136(5):1835-42.
1995: Malozowski S; Parmer T G; Trojan S; Merriam G R; Gibori G; Roberts C T; LeRoith D; Werner H; Zilberstein M
Growth hormone (GH) modulates insulin-like growth factor I (IGF-I) and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats.
European journal of endocrinology / European Federation of Endocrine Societies 1995;132(4):497-501.
1995: LeRoith D; Werner H; Beitner-Johnson D; Roberts C T
Molecular and cellular aspects of the insulin-like growth factor I receptor.
Endocrine reviews 1995;16(2):143-63.
1995: Domené H M; Cassorla F; Werner H; Roberts C T; Leroith D
Rat growth hormone receptor/growth hormone-binding protein mRNAs with divergent 5'-untranslated regions are expressed in a tissue-specific manner.
DNA and cell biology 1995;14(3):195-204.
1995: Blakesley V A; Kato H; Roberts C T; LeRoith D
Mutation of a conserved amino acid residue (tryptophan 1173) in the tyrosine kinase domain of the IGF-I receptor abolishes autophosphorylation but does not eliminate biologic function.
The Journal of biological chemistry 1995;270(6):2764-9.
1995: Pash J M; Delany A M; Adamo M L; Roberts C T; LeRoith D; Canalis E
Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells.
Endocrinology 1995;136(1):33-8.
1995: LeRoith D; Baserga R; Helman L; Roberts C T
Insulin-like growth factors and cancer.
Annals of internal medicine 1995;122(1):54-9.
1995: Karas M; Kleinman D; Danilenko M; Roberts C T; LeRoith D; Levy J; Sharoni Y
Components of the IGF system mediate the opposing effects of tamoxifen on endometrial and breast cancer cell growth.
Progress in growth factor research 1995;6(2-4):513-20.
1994: Roberts C T; Breed W G; Mayrhofer G
Origin of the oocyte shell membrane of a dasyurid marsupial: an immunohistochemical study.
The Journal of experimental zoology 1994;270(3):321-31.
1994: Koval A; Kulik V; Duguay S; Plisetskaya E; Adamo M L; Roberts C T; Leroith D; Kavsan V
Characterization of a salmon insulin-like growth factor I promoter.
DNA and cell biology 1994;13(10):1057-62.
1994: Menon R K; Stephan D A; Rao R H; Shen-Orr Z; Downs L S; Roberts C T; LeRoith D; Sperling M A
Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat.
The Journal of endocrinology 1994;142(3):453-62.
1994: Roberts C T; Breed W G
Embryonic-maternal cell interactions at implantation in the fat-tailed dunnart, a dasyurid marsupial.
The Anatomical record 1994;240(1):59-76.
1994: Bikle D D; Harris J; Halloran B P; Roberts C T; Leroith D; Morey-Holton E
Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth.
The American journal of physiology 1994;267(2 Pt 1):E278-86.
1994: Yakar S; Domene H; Meidan R; Cassorla F; Gilad I; Koch I; Laron Z; Roberts C T; LeRoith D; Eshet R
Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-binding protein (IGFBP)-2 gene expression in spleens of juvenile rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1994;26(8):363-6.
1994: Domené H M; Meidan R; Yakar S; Shen-Orr Z; Cassorla F; Roberts C T; LeRoith D
Role of GH and IGF-I in the regulation of IGF-I, IGF-I receptor and IGF binding protein gene expression in the rat spleen.
Regulatory peptides 1994;52(3):215-26.
1994: Mastick C C; Kato H; Roberts C T; LeRoith D; Saltiel A R
Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation.
Endocrinology 1994;135(1):214-22.
1994: el-Roeiy A; Chen X; Roberts V J; Shimasakai S; Ling N; LeRoith D; Roberts C T; Yen S S
Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries.
The Journal of clinical endocrinology and metabolism 1994;78(6):1488-96.
1994: Butler A A; Ambler G R; Breier B H; LeRoith D; Roberts C T; Gluckman P D
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment of the GH-deficient dwarf rat: differential effects on IGF-I transcription start site expression in hepatic and extrahepatic tissues and lack of effect on type I IGF receptor mRNA expression.
Molecular and cellular endocrinology 1994;101(1-2):321-30.
1994: Faria T N; Blakesley V A; Kato H; Stannard B; LeRoith D; Roberts C T
Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function.
The Journal of biological chemistry 1994;269(19):13922-8.
1994: Zanconato S; Moromisato D Y; Moromisato M Y; Woods J; Brasel J A; Leroith D; Roberts C T; Cooper D M
Effect of training and growth hormone suppression on insulin-like growth factor I mRNA in young rats.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(5):2204-9.
1994: Kavsan V M; Grebenjuk V A; Koval A P; Skorokhod A S; Roberts C T; Leroith D
Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome.
DNA and cell biology 1994;13(5):555-9.
1994: Werner H; Rauscher F J; Sukhatme V P; Drummond I A; Roberts C T; LeRoith D
Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site.
The Journal of biological chemistry 1994;269(17):12577-82.
1994: Rubini M; Werner H; Gandini E; Roberts C T; LeRoith D; Baserga R
Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene.
Experimental cell research 1994;211(2):374-9.
1994: Phillip M; Werner H; Palese T; Kowarski A A; Stannard B; Bach L A; LeRoith D; Roberts C T
Differential accumulation of insulin-like growth factor-I in kidneys of pre- and postpubertal streptozotocin-diabetic rats.
Journal of molecular endocrinology 1994;12(2):215-24.
1994: Nadiv O; Shinitzky M; Manu H; Hecht D; Roberts C T; LeRoith D; Zick Y
Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats.
The Biochemical journal 1994;298 ( Pt 2)():443-50.
1994: Jaffa A A; LeRoith D; Roberts C T; Rust P F; Mayfield R K
Insulin-like growth factor I produces renal hyperfiltration by a kinin-mediated mechanism.
The American journal of physiology 1994;266(1 Pt 2):F102-7.
1994: Roberts C T; Breed W G
Placentation in the dasyurid marsupial, Sminthopsis crassicaudata, the fat-tailed dunnart, and notes on placentation of the didelphid, Monodelphis domestica.
Journal of reproduction and fertility 1994;100(1):105-13.
1994: Kato H; Faria T N; Stannard B; Roberts C T; LeRoith D
Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.
Molecular endocrinology (Baltimore, Md.) 1994;8(1):40-50.
1994: Chen J C; Shao Z M; Sheikh M S; Hussain A; LeRoith D; Roberts C T; Fontana J A
Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line.
Journal of cellular physiology 1994;158(1):69-78.
1994: LeRoith D; Sampson P C; Roberts C T
How does the mitogenic insulin-like growth factor I receptor differ from the metabolic insulin receptor?
Hormone research 1994;41 Suppl 2():74-8; discussion 79.
1994: Werner H; Adamo M; Roberts C T; LeRoith D
Molecular and cellular aspects of insulin-like growth factor action.
Vitamins and hormones 1994;48():1-58.
1993: LeRoith D; Werner H; Phillip M; Roberts C T
The role of insulin-like growth factors in diabetic kidney disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1993;22(5):722-6.
1993: Hadari Y R; Geiger B; Nadiv O; Sabanay I; Roberts C T; LeRoith D; Zick Y
Hepatic tyrosine-phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: effects of H2O2 and vanadate administration into rat livers.
Molecular and cellular endocrinology 1993;97(1-2):9-17.
1993: el-Roeiy A; Chen X; Roberts V J; LeRoith D; Roberts C T; Yen S S
Expression of insulin-like growth factor-I (IGF-I) and IGF-II and the IGF-I, IGF-II, and insulin receptor genes and localization of the gene products in the human ovary.
The Journal of clinical endocrinology and metabolism 1993;77(5):1411-8.
1993: Shemer J; Yaron A; Werner H; Shao Z M; Sheikh M S; Fontana J A; LeRoith D; Roberts C T
Regulation of insulin-like growth factor (IGF) binding protein-5 in the T47D human breast carcinoma cell line by IGF-I and retinoic acid.
The Journal of clinical endocrinology and metabolism 1993;77(5):1246-50.
1993: Hershkovitz E; Marbach M; Bosin E; Levy J; Roberts C T; LeRoith D; Schally A V; Sharoni Y
Luteinizing hormone-releasing hormone antagonists interfere with autocrine and paracrine growth stimulation of MCF-7 mammary cancer cells by insulin-like growth factors.
The Journal of clinical endocrinology and metabolism 1993;77(4):963-8.
1993: Kavsan V M; Koval A P; Grebenjuk V A; Chan S J; Steiner D F; Roberts C T; LeRoith D
Structure of the chum salmon insulin-like growth factor I gene.
DNA and cell biology 1993;12(8):729-37.
1993: Kleinman D; Roberts C T; LeRoith D; Schally A V; Levy J; Sharoni Y
Regulation of endometrial cancer cell growth by insulin-like growth factors and the luteinizing hormone-releasing hormone antagonist SB-75.
Regulatory peptides 1993;48(1-2):91-8.
1993: LeRoith D; Kavsan V M; Koval A P; Roberts C T
Phylogeny of the insulin-like growth factors (IGFs) and receptors: a molecular approach.
Molecular reproduction and development 1993;35(4):332-6; discussion 337-8.
1993: LeRoith D; Roberts C T
Insulin-like growth factors.
Annals of the New York Academy of Sciences 1993;692():1-9.
1993: LeRoith D; Werner H; Faria T N; Kato H; Adamo M; Roberts C T
Insulin-like growth factor receptors. Implications for nervous system function.
Annals of the New York Academy of Sciences 1993;692():22-32.
1993: Adamo M L; Shemer J; Roberts C T; LeRoith D
Insulin and insulin-like growth factor-I induced phosphorylation in neurally derived cells.
Annals of the New York Academy of Sciences 1993;692():113-25.
1993: Ferber A; Chang C; Sell C; Ptasznik A; Cristofalo V J; Hubbard K; Ozer H L; Adamo M; Roberts C T; LeRoith D
Failure of senescent human fibroblasts to express the insulin-like growth factor-1 gene.
The Journal of biological chemistry 1993;268(24):17883-8.
1993: Domené H; Krishnamurthi K; Eshet R; Gilad I; Laron Z; Koch I; Stannard B; Cassorla F; Roberts C T; LeRoith D
Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-I-binding protein-3, but not GH receptor gene expression in livers of juvenile rats.
Endocrinology 1993;133(2):675-82.
1993: LeRoith D; Roberts C T
Insulin-like growth factors and their receptors in normal physiology and pathological states.
The Journal of pediatric endocrinology 1993;6(3-4):251-5.
1993: Kato H; Faria T N; Stannard B; Levy-Toledano R; Taylor S I; Roberts C T; LeRoith D
Paradoxical biological effects of overexpressed insulin-like growth factor-1 receptors in Chinese hamster ovary cells.
Journal of cellular physiology 1993;156(1):145-52.
1993: Botero L F; Roberts C T; LeRoith D; Adashi E Y; Hernandez E R
Insulin-like growth factor I gene expression by primary cultures of ovarian cells: insulin and dexamethasone dependence.
Endocrinology 1993;132(6):2703-8.
1993: Woloschak M; Shen-Orr Z; LeRoith D; Roberts C T
Nutritional regulation of insulin-sensitive glucose transporter gene expression in rat cardiac muscle.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;203(2):172-4.
1993: Werner H; Re G G; Drummond I A; Sukhatme V P; Rauscher F J; Sens D A; Garvin A J; LeRoith D; Roberts C T
Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5828-32.
1993: Sheikh M S; Shao Z M; Hussain A; Chen J C; Roberts C T; LeRoith D; Fontana J A
Retinoic acid and estrogen modulation of insulin-like growth factor binding protein-4 gene expression and the estrogen receptor status of human breast carcinoma cells.
Biochemical and biophysical research communications 1993;193(3):1232-8.
1993: Sheikh M S; Shao Z M; Hussain A; Clemmons D R; Chen J C; Roberts C T; LeRoith D; Fontana J A
Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5, and 6: synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells.
Journal of cellular physiology 1993;155(3):556-67.
1993: Eshet R; Werner H; Klinger B; Silbergeld A; Laron Z; LeRoith D; Roberts C T
Up-regulation of insulin-like growth factor-I (IGF-I) receptor gene expression in patients with reduced serum IGF-I levels.
Journal of molecular endocrinology 1993;10(2):115-20.
1993: Kavsan V; Koval A; Petrenko O; Roberts C T; LeRoith D
Two insulin genes are present in the salmon genome.
Biochemical and biophysical research communications 1993;191(3):1373-8.
1993: LeRoith D; Adamo M L; Shemer J; Lanau F; Shen-Orr Z; Yaron A; Roberts C T; Clemmons D R; Sheikh M S; Shao Z M
Retinoic acid inhibits growth of breast cancer cell lines: the role of insulin-like growth factor binding proteins.
Growth regulation 1993;3(1):78-80.
1993: Adamo M L; Lanau F; Neuenschwander S; Werner H; LeRoith D; Roberts C T
Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells.
Endocrinology 1993;132(2):935-7.
1993: Kato H; Faria T N; Stannard B; Roberts C T; LeRoith D
Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).
The Journal of biological chemistry 1993;268(4):2655-61.
1993: Werner H; Roberts C T; LeRoith D
The regulation of IGF-I receptor gene expression by positive and negative zinc-finger transcription factors.
Advances in experimental medicine and biology 1993;343():91-103.
1993: Adamo M L; Neuenschwander S; LeRoith D; Roberts C T
Structure, expression, and regulation of the IGF-I gene.
Advances in experimental medicine and biology 1993;343():1-11.
1992: Shemer J; Adamo M L; Roberts C T; LeRoith D
Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: evidence for differential regulation in the developing kidney.
Endocrinology 1992;131(6):2793-9.
1992: Porcu P; Ferber A; Pietrzkowski Z; Roberts C T; Adamo M; LeRoith D; Baserga R
The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor.
Molecular and cellular biology 1992;12(11):5069-77.
1992: Foyt H L; Lanau F; Woloschak M; LeRoith D; Roberts C T
Effect of growth hormone on levels of differentially processed insulin-like growth factor I mRNAs in total and polysomal mRNA populations.
Molecular endocrinology (Baltimore, Md.) 1992;6(11):1881-8.
1992: Sheikh M S; Shao Z M; Chen J C; Clemmons D R; Roberts C T; LeRoith D; Fontana J A
Insulin-like growth factor binding protein-5 gene expression is differentially regulated at a post-transcriptional level in retinoic acid-sensitive and resistant MCF-7 human breast carcinoma cells.
Biochemical and biophysical research communications 1992;188(3):1122-30.
1992: Werner H; Bach M A; Stannard B; Roberts C T; LeRoith D
Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1545-58.
1992: Adamo M L; Shao Z M; Lanau F; Chen J C; Clemmons D R; Roberts C T; LeRoith D; Fontana J A
Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line.
Endocrinology 1992;131(4):1858-66.
1992: Hadari Y R; Tzahar E; Nadiv O; Rothenberg P; Roberts C T; LeRoith D; Yarden Y; Zick Y
Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.
The Journal of biological chemistry 1992;267(25):17483-6.
1992: Shao Z M; Sheikh M S; Ordonez J V; Feng P; Kute T; Chen J C; Aisner S; Schnaper L; LeRoith D; Roberts C T
IGFBP-3 gene expression and estrogen receptor status in human breast carcinoma.
Cancer research 1992;52(18):5100-3.
1992: Levy M J; Hernandez E R; Adashi E Y; Stillman R J; Roberts C T; LeRoith D
Expression of the insulin-like growth factor (IGF)-I and -II and the IGF-I and -II receptor genes during postnatal development of the rat ovary.
Endocrinology 1992;131(3):1202-6.
1992: LeRoith D; McGuinness M; Shemer J; Stannard B; Lanau F; Faria T N; Kato H; Werner H; Adamo M; Roberts C T
Insulin-like growth factors.
Biological signals 1992;1(4):173-81.
1992: Eastman R C; Carson R E; Orloff D G; Cochran C S; Perdue J F; Rechler M M; Lanau F; Roberts C T; Shapiro J; Roth J
Glucose utilization in a patient with hepatoma and hypoglycemia. Assessment by a positron emission tomography.
The Journal of clinical investigation 1992;89(6):1958-63.
1992: Sklar M M; Thomas C L; Municchi G; Roberts C T; LeRoith D; Kiess W; Nissley P
Developmental expression of rat insulin-like growth factor-II/mannose 6-phosphate receptor messenger ribonucleic acid.
Endocrinology 1992;130(6):3484-91.
1992: Phillip M; Palese T; Hernandez E R; Roberts C T; LeRoith D; Kowarski A A
Effect of testosterone on insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the hypophysectomized rat.
Endocrinology 1992;130(5):2865-70.
1992: Mulroney S E; Lumpkin M D; Roberts C T; LeRoith D; Haramati A
Effect of a growth hormone-releasing factor antagonist on compensatory renal growth, insulin-like growth factor-I (IGF-I), and IGF-I receptor gene expression after unilateral nephrectomy in immature rats.
Endocrinology 1992;130(5):2697-702.
1992: Adashi E Y; Resnick C E; Hurwitz A; Ricciarellie E; Hernandez E R; Roberts C T; Leroith D; Rosenfeld R
The intra-ovarian IGF system.
Growth regulation 1992;2(1):10-5.
1992: Sheikh M S; Shao Z M; Clemmons D R; LeRoith D; Roberts C T; Fontana J A
Identification of the insulin-like growth factor binding proteins 5 and 6 (IGFBP-5 and 6) in human breast cancer cells.
Biochemical and biophysical research communications 1992;183(3):1003-10.
1992: Hernandez E R; Hurwitz A; Vera A; Pellicer A; Adashi E Y; LeRoith D; Roberts C T
Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary.
The Journal of clinical endocrinology and metabolism 1992;74(2):419-25.
1992: Adamo M; Roberts C T; LeRoith D
How distinct are the insulin and insulin-like growth factor I signalling systems?
BioFactors (Oxford, England) 1992;3(3):151-7.
1992: Mulroney S E; Haramati A; Werner H; Bondy C; Roberts C T; LeRoith D
Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats.
Endocrinology 1992;130(1):249-56.
1992: Bondy C; Werner H; Roberts C T; LeRoith D
Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II.
Neuroscience 1992;46(4):909-23.
1992: LeRoith D; Shemer J; Roberts C T
Evolutionary origins of intercellular communication systems: implications for mammalian biology.
Hormone research 1992;38 Suppl 2():1-6.
1992: LeRoith D; Werner H; Burguera B; Roberts C T; Mulroney S; Haramati A
The insulin-like growth factor family of peptides, binding proteins and receptors: their potential role in tissue regeneration.
Advances in experimental medicine and biology 1992;321():21-8; discussion 29-30.
1991: Hernandez E R; Hurwitz A; Botero L; Ricciarelli E; Werner H; Roberts C T; LeRoith D; Adashi E Y
Insulin-like growth factor receptor gene expression in the rat ovary: divergent regulation of distinct receptor species.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):1799-805.
1991: Parmer T G; Roberts C T; LeRoith D; Adashi E Y; Khan I; Solan N; Nelson S; Zilberstein M; Gibori G
Expression, action, and steroidal regulation of insulin-like growth factor-I (IGF-I) and IGF-I receptor in the rat corpus luteum: their differential role in the two cell populations forming the corpus luteum.
Endocrinology 1991;129(6):2924-32.
1991: Adamo M L; Ben-Hur H; Roberts C T; LeRoith D
Regulation of start site usage in the leader exons of the rat insulin-like growth factor-I gene by development, fasting, and diabetes.
Molecular endocrinology (Baltimore, Md.) 1991;5(11):1677-86.
1991: Adashi E Y; Resnick C E; Hurwitz A; Ricciarelli E; Hernandez E R; Roberts C T; Leroith D; Rosenfeld R
Insulin-like growth factors: the ovarian connection.
Human reproduction (Oxford, England) 1991;6(9):1213-9.
1991: Jansen E; Steenbergh P H; LeRoith D; Roberts C T; Sussenbach J S
Identification of multiple transcription start sites in the human insulin-like growth factor-I gene.
Molecular and cellular endocrinology 1991;78(1-2):115-25.
1991: Cooke D W; Bankert L A; Roberts C T; LeRoith D; Casella S J
Analysis of the human type I insulin-like growth factor receptor promoter region.
Biochemical and biophysical research communications 1991;177(3):1113-20.
1991: Mulroney S E; Haramati A; Roberts C T; LeRoith D
Renal IGF-1 mRNA levels are enhanced following unilateral nephrectomy in immature but not adult rats.
Endocrinology 1991;128(5):2660-2.
1991: Masters B A; Werner H; Roberts C T; LeRoith D; Raizada M K
Developmental regulation of insulin-like growth factor-I-stimulated glucose transporter in rat brain astrocytes.
Endocrinology 1991;128(5):2548-57.
1991: LeRoith D; Roberts C T
Insulin-like growth factor I (IGF-I): a molecular basis for endocrine versus local action?
Molecular and cellular endocrinology 1991;77(1-3):C57-61.
1991: Adamo M L; Ben-Hur H; LeRoith D; Roberts C T
Transcription initiation in the two leader exons of the rat IGF-I gene occurs from disperse versus localized sites.
Biochemical and biophysical research communications 1991;176(2):887-93.
1991: Foyt H L; LeRoith D; Roberts C T
Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo.
The Journal of biological chemistry 1991;266(11):7300-5.
1991: Masters B A; Werner H; Roberts C T; LeRoith D; Raizada M K
Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains.
Regulatory peptides 1991;33(2):117-31.
1991: Bach M A; Shen-Orr Z; Lowe W L; Roberts C T; LeRoith D
Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain.
Brain research. Molecular brain research 1991;10(1):43-8.
1991: Wood T L; Berelowitz M; Gelato M C; Roberts C T; LeRoith D; Millard W J; McKelvy J F
Hormonal regulation of rat hypothalamic neuropeptide mRNAs: effect of hypophysectomy and hormone replacement on growth-hormone-releasing factor, somatostatin and the insulin-like growth factors.
Neuroendocrinology 1991;53(3):298-305.
1991: Adashi E Y; Resnick C E; Hernandez E R; Hurwitz A; Roberts C T; Leroith D; Rosenfeld R
Insulin-like growth factor I as an intraovarian regulator: basic and clinical implications.
Annals of the New York Academy of Sciences 1991;626():161-8.
1991: Werner H; Stannard B; Bach M A; Roberts C T; LeRoith D
Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states.
Advances in experimental medicine and biology 1991;293():263-72.
1990: Hernandez E R; Roberts C T; Hurwitz A; LeRoith D; Adashi E Y
Rat ovarian insulin-like growth factor II gene expression is theca-interstitial cell-exclusive: hormonal regulation and receptor distribution.
Endocrinology 1990;127(6):3249-51.
1990: Werner H; Shen-Orr Z; Stannard B; Burguera B; Roberts C T; LeRoith D
Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney.
Diabetes 1990;39(12):1490-7.
1990: Burguera B; Werner H; Sklar M; Shen-Orr Z; Stannard B; Roberts C T; Nissley S P; Vore S J; Caro J F; LeRoith D
Liver regeneration is associated with increased expression of the insulin-like growth factor-II/mannose-6-phosphate receptor.
Molecular endocrinology (Baltimore, Md.) 1990;4(10):1539-45.
1990: Serrano J; Shuldiner A R; Roberts C T; LeRoith D; de Pablo F
The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis.
Endocrinology 1990;127(3):1547-9.
1990: Bondy C A; Werner H; Roberts C T; LeRoith D
Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression.
Molecular endocrinology (Baltimore, Md.) 1990;4(9):1386-98.
1990: Bach M A; Roberts C T; Smith E P; LeRoith D
Alternative splicing produces messenger RNAs encoding insulin-like growth factor-I prohormones that are differentially glycosylated in vitro.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):899-904.
1990: Werner H; Stannard B; Bach M A; LeRoith D; Roberts C T
Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene.
Biochemical and biophysical research communications 1990;169(3):1021-7.
1990: Mudd L M; Werner H; Shen-Orr Z; Roberts C T; LeRoith D; Haspel H C; Raizada M K
Regulation of rat brain/HepG2 glucose transporter gene expression by phorbol esters in primary cultures of neuronal and astrocytic glial cells.
Endocrinology 1990;126(1):545-9.
1990: Jansson J O; Carlsson L; Ekberg S; Isgaard J; Carlsson B; Billig H; Leroith D; Roberts C T; Adamo M; Woloschak M
Pulsatile growth hormone secretory pattern: autofeedback regulation and effects on growth factors.
Acta paediatrica Scandinavica. Supplement 1990;367():98-102.
1989: Lowe W L; Roberts C T; LeRoith D; Rojeski M T; Merimee T J; Fui S T; Keen H; Arnold D; Mersey J; Gluzman S
Insulin-like growth factor-II in nonislet cell tumors associated with hypoglycemia: increased levels of messenger ribonucleic acid.
The Journal of clinical endocrinology and metabolism 1989;69(6):1153-9.
1989: Werner H; Woloschak M; Adamo M; Shen-Orr Z; Roberts C T; LeRoith D
Developmental regulation of the rat insulin-like growth factor I receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7451-5.
1989: Zilberstein M; Chou J Y; Lowe W L; Shen-Orr Z; Roberts C T; LeRoith D; Catt K J
Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(9):1488-97.
1989: Lowe W L; Adamo M; LeRoith D; Roberts C T
Expression and stability of insulin-like growth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line.
Biochemical and biophysical research communications 1989;162(3):1174-9.
1989: Lowe W L; Adamo M; Werner H; Roberts C T; LeRoith D
Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding.
The Journal of clinical investigation 1989;84(2):619-26.
1989: Ota A; Shen-Orr Z; Roberts C T; LeRoith D
TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding.
Brain research. Molecular brain research 1989;6(1):69-76.
1989: Hernandez E R; Roberts C T; LeRoith D; Adashi E Y
Rat ovarian insulin-like growth factor I (IGF-I) gene expression is granulosa cell-selective: 5'-untranslated mRNA variant representation and hormonal regulation.
Endocrinology 1989;125(1):572-4.
1989: Werner H; Raizada M K; Mudd L M; Foyt H L; Simpson I A; Roberts C T; LeRoith D
Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells.
Endocrinology 1989;125(1):314-20.
1989: Shuldiner A R; Phillips S; Roberts C T; LeRoith D; Roth J
Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective.
The Journal of biological chemistry 1989;264(16):9428-32.
1989: Adamo M; Lowe W L; LeRoith D; Roberts C T
Insulin-like growth factor I messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed during development of the rat.
Endocrinology 1989;124(6):2737-44.
1989: Bucci C; Mallucci P; Roberts C T; Frunzio R; Bruni C B
Nucleotide sequence of a genomic fragment of the rat IGF-I gene spanning an alternate 5' non coding exon.
Nucleic acids research 1989;17(9):3596.
1989: Fagin J A; Roberts C T; LeRoith D; Brown A T
Coordinate decrease of tissue insulinlike growth factor I posttranscriptional alternative mRNA transcripts in diabetes mellitus.
Diabetes 1989;38(4):428-34.
1989: Werner H; Adamo M; Lowe W L; Roberts C T; LeRoith D
Developmental regulation of rat brain/Hep G2 glucose transporter gene expression.
Molecular endocrinology (Baltimore, Md.) 1989;3(2):273-9.
1988: Roberts C T; Leroith D
Molecular aspects of insulin-like growth factors, their binding proteins and receptors.
Baillière's clinical endocrinology and metabolism 1988;2(4):1069-85.
1988: Adamo M; Werner H; Farnsworth W; Roberts C T; Raizada M; LeRoith D
Dexamethasone reduces steady state insulin-like growth factor I messenger ribonucleic acid levels in rat neuronal and glial cells in primary culture.
Endocrinology 1988;123(5):2565-70.
1988: Lowe W L; Lasky S R; LeRoith D; Roberts C T
Distribution and regulation of rat insulin-like growth factor I messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: evidence for differential processing and regulation in liver.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):528-35.
1988: Ojamaa K; Hedo J A; Roberts C T; Moncada V Y; Gorden P; Ullrich A; Taylor S I
Defects in human insulin receptor gene expression.
Molecular endocrinology (Baltimore, Md.) 1988;2(3):242-7.
1987: Lowe W L; Roberts C T; Lasky S R; LeRoith D
Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8946-50.
1987: Roberts C T; Lasky S R; Lowe W L; LeRoith D
Rat IGF-I cDNA's contain multiple 5'-untranslated regions.
Biochemical and biophysical research communications 1987;146(3):1154-9.
1987: Roberts C T; Lasky S R; Lowe W L; Seaman W T; LeRoith D
Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues.
Molecular endocrinology (Baltimore, Md.) 1987;1(3):243-8.
1987: Lowe W L; Schaffner A E; Roberts C T; LeRoith D
Developmental regulation of somatostatin gene expression in the brain is region specific.
Molecular endocrinology (Baltimore, Md.) 1987;1(2):181-7.
1986: Roberts C T; Brown A L; Graham D E; Seelig S; Berry S; Gabbay K H; Rechler M M
Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver.
The Journal of biological chemistry 1986;261(22):10025-8.
1986: LeRoith D; Delahunty G; Wilson G L; Roberts C T; Shemer J; Hart C; Lesniak M A; Shiloach J; Roth J
Evolutionary aspects of the endocrine and nervous systems.
Recent progress in hormone research 1986;42():549-87.
1982: Lavine J E; Roberts C T; Morse D E
Glucose regulation of specific gene expression is altered in a glucokinase-deficient mutant of Tetrahymena.
Molecular and cellular biochemistry 1982;48(1):48-58.
1982: Lavine J E; Cantlay E; Roberts C T; Morse D E
Purification and properties of galactokinase from Tetrahymena thermophila.
Biochimica et biophysica acta 1982;717(1):76-85.
1982: Roberts C T; Lavine J E; Morse D E
Selection and characterization of a glucokinase-deficient mutant of Tetrahymena thermophila.
Molecular and cellular biology 1982;2(4):378-85.
1980: Roberts C T; Morse D E
Galactokinase-deficient mutants of Tetrahymena thermophila: selection and characterization.
Molecular & general genetics : MGG 1980;180(1):129-34.
1978: Roberts C T; Morse D E
Genetic regulation of galactokinase in Tetrahymena by cyclic AMP glucose, and epinephrine.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(4):1810-4.
1974: Roberts C T; Orias E
On the mechanism of adaptation to protein synthesis inhibitors by Tetrahymena. Facilitation, cross adaptation, and resensitization.
The Journal of cell biology 1974;62(3):707-16.

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