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James Roberts

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Publications

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Hui Zhao; Xueyan Chen; Mark Gurian-West; James M Roberts
Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.
Liyun Sang; Hilary A Coller; James M Roberts
Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.
Carrie M Garrett-Engele; Michael A Tasch; Harry C Hwang; Matthew L Fero; Roger M Perlmutter; Bruce E Clurman; James M Roberts
A mechanism misregulating p27 in tumors discovered in a functional genomic screen.

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All Publications

2012: Hui Zhao; Xueyan Chen; Mark Gurian-West; James M Roberts
Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.
Molecular and cellular biology 2012;32(8):1421-32.
2008: Liyun Sang; Hilary A Coller; James M Roberts
Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.
Science (New York, N.Y.) 2008;321(5892):1095-100.
2007: Carrie M Garrett-Engele; Michael A Tasch; Harry C Hwang; Matthew L Fero; Roger M Perlmutter; Bruce E Clurman; James M Roberts
A mechanism misregulating p27 in tumors discovered in a functional genomic screen.
PLoS genetics 2007;3(12):e219.
2007: Arnaud Besson; Harry C Hwang; Samantha Cicero; Stacy L Donovan; Mark Gurian-West; Dianna Johnson; Bruce E Clurman; Michael A Dyer; James M Roberts
Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.
Genes & development 2007;21(14):1731-46.
2007: Xueyan Chen; Lance F Barton; Yong Chi; Bruce E Clurman; James M Roberts
Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome.
Molecular cell 2007;26(6):843-52.
2007: Yan Geng; Young-Mi Lee; Markus Welcker; Jherek Swanger; Agnieszka Zagozdzon; Joel D Winer; James M Roberts; Philipp Kaldis; Bruce E Clurman; Piotr Sicinski
Kinase-independent function of cyclin E.
Molecular cell 2007;25(1):127-39.
2006: Peggy L Porter; William E Barlow; I-Tien Yeh; Ming Gang Lin; Xiaopu P Yuan; Elizabeth Donato; George W Sledge; Charles L Shapiro; James N Ingle; Charles M Haskell; Kathy S Albain; James M Roberts; Robert B Livingston; Daniel F Hayes
p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy.
Journal of the National Cancer Institute 2006;98(23):1723-31.
2006: Arnaud Besson; Mark Gurian-West; Xueyan Chen; Karen S Kelly-Spratt; Christopher J Kemp; James M Roberts
A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression.
Genes & development 2006;20(1):47-64.
2005: Keith R Loeb; Heather Kostner; Eduardo Firpo; Thomas H Norwood; Karen D Tsuchiya; Bruce E Clurman; James M Roberts
A mouse model for cyclin E-dependent genetic instability and tumorigenesis.
Cancer cell 2005;8(1):35-47.
2004: Xueyan Chen; Yong Chi; Andrew Bloecher; Ruedi Aebersold; Bruce E Clurman; James M Roberts
N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1).
Molecular cell 2004;16(5):839-47.
2004: Arnaud Besson; Richard K Assoian; James M Roberts
Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?
Nature reviews. Cancer 2004;4(12):948-55.
2004: Arnaud Besson; Mark Gurian-West; Anja Schmidt; Alan Hall; James M Roberts
p27Kip1 modulates cell migration through the regulation of RhoA activation.
Genes & development 2004;18(8):862-76.
2003: Markus Welcker; Jeffrey Singer; Keith R Loeb; Jonathan Grim; Andrew Bloecher; Mark Gurien-West; Bruce E Clurman; James M Roberts
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.
Molecular cell 2003;12(2):381-92.
2003: Laura L Smith; Hilary A Coller; James M Roberts
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation.
Nature cell biology 2003;5(5):474-9.
2002: Grant A McArthur; Kevin P Foley; Matthew L Fero; Carl R Walkley; Andrew Deans; James M Roberts; Robert N Eisenman
MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity.
Molecular and cellular biology 2002;22(9):3014-23.
2001: N P Malek; H Sundberg; S McGrew; K Nakayama; T R Kyriakides; James M Roberts; T R Kyriakidis
A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase.
Nature 2001;413(6853):323-7.
2000: RJ Sheaff; J D Singer; Jherek Swanger; M Smitherman; James M Roberts; Bruce E Clurman
Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination.
Molecular cell 2000;5(2):403-10.
1999: James M Roberts
Evolving ideas about cyclins.
Cell 1999;98(2):129-32.
1999: Steven R Coats; Peter Whyte; Matthew L Fero; S Lacy; Grace Chung; E Randel; E Firpo; James M Roberts
A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells.
Current biology : CB 1999;9(4):163-73.
1998: Matthew L Fero; E Randel; Kay E Gurley; James M Roberts; Christopher J Kemp
The murine gene p27Kip1 is haplo-insufficient for tumour suppression.
Nature 1998;396(6707):177-80.
1998: B L Kelly; K G Wolfe; James M Roberts
Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2535-40.
1998: K A Heichman; James M Roberts
CDC16 controls initiation at chromosome replication origins.
Molecular cell 1998;1(3):457-63.
1998: RJ Sheaff; James M Roberts
Regulation of G1 phase.
Results and problems in cell differentiation 1998;22():1-34.
1997: RJ Sheaff; Mark Groudine; M Gordon; James M Roberts; Bruce E Clurman
Cyclin E-CDK2 is a regulator of p27Kip1.
Genes & development 1997;11(11):1464-78.
1996: Bruce E Clurman; RJ Sheaff; K Thress; Mark Groudine; James M Roberts
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.
Genes & development 1996;10(16):1979-90.
1996: Bruce E Clurman; James M Roberts; Mark Groudine
Deregulation of cell cycle control in hematologic malignancies.
Current opinion in hematology 1996;3(4):315-20.
1996: Matthew L Fero; M Rivkin; M Tasch; P Porter; C E Carow; E Firpo; Kornelia Polyak; Li-Huei Tsai; V Broudy; R M Perlmutter; K Kaushansky; James M Roberts
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.
Cell 1996;85(5):733-44.
1996: Steven R Coats; W M Flanagan; J Nourse; James M Roberts
Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle.
Science (New York, N.Y.) 1996;272(5263):877-80.
1996: K A Heichman; James M Roberts
The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle.
Cell 1996;85(1):39-48.
1995: M Ohtsubo; A M Theodoras; J Schumacher; James M Roberts; M Pagano
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition.
Molecular and cellular biology 1995;15(5):2612-24.
1995: R J Sheaff; James M Roberts
Tumor suppression. Lessons in p16 from phylum Falconium.
Current biology : CB 1995;5(1):28-31.
1994: J Nourse; E Firpo; W M Flanagan; Steven R Coats; Kornelia Polyak; M H Lee; J Massague; Gerald R Crabtree; James M Roberts
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin.
Nature 1994;372(6506):570-3.
1994: K A Heichman; James M Roberts
Rules to replicate by.
Cell 1994;79(4):557-62.
1994: Kornelia Polyak; M H Lee; Hediye Erdjument-Bromage; Andrew Koff; James M Roberts; Paul Tempst; Joan Massagué
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
Cell 1994;78(1):59-66.
1994: E J Firpo; Andrew Koff; M J Solomon; James M Roberts
Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.
Molecular and cellular biology 1994;14(7):4889-901.
1994: Kornelia Polyak; J Y Kato; M J Solomon; Charles J Sherr; J Massague; James M Roberts; Andrew Koff
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
Genes & development 1994;8(1):9-22.
1994: James M Roberts; Andrew Koff; Kornelia Polyak; E Firpo; S Collins; M Ohtsubo; Joan Massagué
Cyclins, Cdks, and cyclin kinase inhibitors.
Cold Spring Harbor symposia on quantitative biology 1994;59():31-8.
1993: Andrew Koff; M Ohtsuki; Kornelia Polyak; James M Roberts; Joan Massagué
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.
Science (New York, N.Y.) 1993;260(5107):536-9.
1993: James M Roberts
Turning DNA replication on and off.
Current opinion in cell biology 1993;5(2):201-6.
1993: M Ohtsubo; James M Roberts
Cyclin-dependent regulation of G1 in mammalian fibroblasts.
Science (New York, N.Y.) 1993;259(5103):1908-12.
1992: Andrew Koff; Antonio Giordano; D Desai; K Yamashita; J W Harper; S Elledge; T Nishimoto; D O Morgan; B R Franza; James M Roberts
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.
Science (New York, N.Y.) 1992;257(5077):1689-94.
1992: R Fotedar; James M Roberts
Cell cycle regulated phosphorylation of RPA-32 occurs within the replication initiation complex.
The EMBO journal 1992;11(6):2177-87.
1992: R L Marraccino; E J Firpo; James M Roberts
Activation of the p34 CDC2 protein kinase at the start of S phase in the human cell cycle.
Molecular biology of the cell 1992;3(4):389-401.
1991: Andrew Koff; F Cross; Alfred L. Fisher; J Schumacher; K Leguellec; M Philippe; James M Roberts
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.
Cell 1991;66(6):1217-28.
1991: R Fotedar; James M Roberts
Association of p34cdc2 with replicating DNA.
Cold Spring Harbor symposia on quantitative biology 1991;56():325-33.
1990: Gennaro D'urso; R L Marraccino; D R Marshak; James M Roberts
Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase.
Science (New York, N.Y.) 1990;250(4982):786-91.
1990: R L Marraccino; R Fotedar; Gennaro D'urso; James M Roberts
Control of DNA replication.
Current opinion in cell biology 1990;2(2):262-8.
1989: R Fotedar; James M Roberts
Multistep pathway for replication-dependent nucleosome assembly.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6459-63.
1989: James M Roberts
Simian virus 40 (SV40) large tumor antigen causes stepwise changes in SV40 origin structure during initiation of DNA replication.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):3939-43.
1988: James M Roberts; Gennaro D'urso
An origin unwinding activity regulates initiation of DNA replication during mammalian cell cycle.
Science (New York, N.Y.) 1988;241(4872):1486-9.
1988: James M Roberts; H Weintraub
Cis-acting negative control of DNA replication in eukaryotic cells.
Cell 1988;52(3):397-404.