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Richard Roberts

Research Profile

Chemicals & Drugs

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Genes & Molecular Sequences

Physiology

DNA Methylation

Living Beings

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Cloning, Molecular

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John Horton; Megumu Yamada Mabuchi; Richard J Roberts; Mala Samaranayake; Xing Zhang; Yu Zheng; Devora Cohen-Karni; Rose M Griggs; Xiaodong Cheng
Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease.
Hua Wang; Geoffrey Wilson; Zhenyu Zhu; devora cohen-karni; Shengxi Guan; Sriharsa Pradhan; Aine Quimby; Richard J Roberts; Yu Zheng
Comparative characterization of the PvuRts1I family of restriction enzymes and their application in mapping genomic 5-hydroxymethylcytosine.
devora cohen-karni; Paul J Davis; Theodore Davis; Alexey Fomenkov; Sriharsa Pradhan; Richard J Roberts; Zhiyi Sun; Derrick Xu; Shuang-Yong Xu; Megumu Yamada-Mabuchi; Lynne Apone; Shannon R Morey Kinney; Yu Zheng
The MspJI family of modification-dependent restriction endonucleases for epigenetic studies.

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2012: John Horton; Megumu Yamada Mabuchi; Richard J Roberts; Mala Samaranayake; Xing Zhang; Yu Zheng; Devora Cohen-Karni; Rose M Griggs; Xiaodong Cheng
Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease.
Nucleic acids research 2012;40(19):9763-73.
2011: Hua Wang; Geoffrey Wilson; Zhenyu Zhu; devora cohen-karni; Shengxi Guan; Sriharsa Pradhan; Aine Quimby; Richard J Roberts; Yu Zheng
Comparative characterization of the PvuRts1I family of restriction enzymes and their application in mapping genomic 5-hydroxymethylcytosine.
Nucleic acids research 2011;39(21):9294-305.
2011: devora cohen-karni; Paul J Davis; Theodore Davis; Alexey Fomenkov; Sriharsa Pradhan; Richard J Roberts; Zhiyi Sun; Derrick Xu; Shuang-Yong Xu; Megumu Yamada-Mabuchi; Lynne Apone; Shannon R Morey Kinney; Yu Zheng
The MspJI family of modification-dependent restriction endonucleases for epigenetic studies.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(27):11040-5.
2011: Richard J Roberts; Yi-Chien Chang; Zhenjun Hu; John Rachlin; Brian P Anton; Revonda M Pokrzywa; Han-Pil Choi; Lina L Faller; Jyotsna Guleria; Genevieve Housman; Niels Klitgord; Varun Mazumdar; Mark G McGettrick; Lais Osmani; Rajeswari Swaminathan; Kevin R Tao; Stan Letovsky; Dennis Vitkup; Daniel Segrè; Steven L Salzberg; Charles DeLisi; Martin Steffen; Simon Kasif
COMBREX: a project to accelerate the functional annotation of prokaryotic genomes.
Nucleic acids research 2011;39(Database issue):D11-4.
2010: Iain A Murray; Shawn K Stickel; Richard J Roberts
Sequence-specific cleavage of RNA by Type II restriction enzymes.
Nucleic acids research 2010;38(22):8257-68.
2010: Brian P Anton; Susan P Russell; Jason Vertrees; Simon Kasif; Elisabeth A Raleigh; Patrick A Limbach; Richard J Roberts
Functional characterization of the YmcB and YqeV tRNA methylthiotransferases of Bacillus subtilis.
Nucleic acids research 2010;38(18):6195-205.
2010: Yu Zheng; devora cohen-karni; Derrick Xu; Hang Gyeong Chin; Geoffrey Wilson; Sriharsa Pradhan; Richard J Roberts
A unique family of Mrr-like modification-dependent restriction endonucleases.
Nucleic acids research 2010;38(16):5527-34.
2010: Richard J Roberts; Tamas Vincze; Janos Posfai; Dana Macelis
REBASE--a database for DNA restriction and modification: enzymes, genes and genomes.
Nucleic acids research 2010;38(Database issue):D234-6.
2009: Yu Zheng; Janos Posfai; Richard D Morgan; Tamas Vincze; Richard J Roberts
Using shotgun sequence data to find active restriction enzyme genes.
Nucleic acids research 2009;37(1):e1.
2008: Masha Y Niv; Lucy Skrabanek; Richard J Roberts; Harold A Scheraga; HAREL WEINSTEIN
Identification of GATC- and CCGG-recognizing Type II REases and their putative specificity-determining positions using Scan2S--a novel motif scan algorithm with optional secondary structure constraints.
Proteins 2008;71(2):631-40.
2008: Brian P Anton; Lana Saleh; Jack Benner; Elisabeth A Raleigh; Simon Kasif; Richard J Roberts
RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):1826-31.
2008: Robert K Neely; Richard J Roberts
The BsaHI restriction-modification system: cloning, sequencing and analysis of conserved motifs.
BMC molecular biology 2008;9():48.
2007: Vittorio Colizzi; Tulio de Oliveira; Richard J Roberts
Libya should stop denying scientific evidence on HIV.
Nature 2007;448(7157):992.
2007: Bevin P Engelward; Richard J Roberts
Open access to research is in the public interest.
PLoS biology 2007;5(2):e48.
2007: Yu Zheng; Richard J Roberts
Selection of restriction endonucleases using artificial cells.
Nucleic acids research 2007;35(11):e83.
2007: Richard J Roberts; Tamas Vincze; Janos Posfai; Dana Macelis
REBASE--enzymes and genes for DNA restriction and modification.
Nucleic acids research 2007;35(Database issue):D269-70.
2006: Richard J Roberts
An open letter to Colonel Muammar al-Gaddafi.
Nature 2006;444(7116):146.
2006: D R Guy; Stephen C Bishop; Sue Brotherstone; Alastair Hamilton; Richard J Roberts; B J McAndrew; J A Woolliams
Analysis of the incidence of infectious pancreatic necrosis mortality in pedigreed Atlantic salmon, Salmo salar L., populations.
Journal of fish diseases 2006;29(11):637-47.
2006: Antoine Danchin; Asao Fujiyama; Ken-ichi Matsubara; Richard J Roberts; Sumio Sugano; Jean Weissenbach
Re: request from the International Advisory Committee to DDBJ/EMBL/GenBank.
Journal of medical virology 2006;78(7):995.
2006: Jonathan O'Driscoll; Daniel F Heiter; Geoffrey G Wilson; Gerald F Fitzgerald; Richard J Roberts; Douwe van Sinderen
A genetic dissection of the LlaJI restriction cassette reveals insights on a novel bacteriophage resistance system.
BMC microbiology 2006;6():40.
2006: John Horton; Xing Zhang; Robert Maunus; Zhe Yang; Geoffrey G Wilson; Richard J Roberts; Xiaodong Cheng
DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansion.
Nucleic acids research 2006;34(3):939-48.
2005: Qian Steven Xu; Richard J Roberts; Hwai-Chen Guo
Two crystal forms of the restriction enzyme MspI-DNA complex show the same novel structure.
Protein science : a publication of the Protein Society 2005;14(10):2590-600.
2005: Yu Zheng; Richard J Roberts; Simon Kasif; Chudi Guan
Characterization of two new aminopeptidases in Escherichia coli.
Journal of bacteriology 2005;187(11):3671-7.
2005: Richard J Roberts
How restriction enzymes became the workhorses of molecular biology.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):5905-8.
2005: Yu Zheng; Brian P Anton; Richard J Roberts; Simon Kasif
Phylogenetic detection of conserved gene clusters in microbial genomes.
BMC bioinformatics 2005;6():243.
2005: Zhe Yang; John Horton; Robert Maunus; Geoffrey G Wilson; Richard J Roberts; Xiaodong Cheng
Structure of HinP1I endonuclease reveals a striking similarity to the monomeric restriction enzyme MspI.
Nucleic acids research 2005;33(6):1892-901.
2005: Richard J Roberts; Tamas Vincze; Janos Posfai; Dana Macelis
REBASE--restriction enzymes and DNA methyltransferases.
Nucleic acids research 2005;33(Database issue):D230-2.
2004: Qian Steven Xu; Rebecca B Kucera; Richard J Roberts; Hwai-Chen Guo
An asymmetric complex of restriction endonuclease MspI on its palindromic DNA recognition site.
Structure (London, England : 1993) 2004;12(9):1741-7.
2004: Zhe Yang; Lance Shipman; Meng Zhang; Brian P Anton; Richard J Roberts; Xiaodong Cheng
Structural characterization and comparative phylogenetic analysis of Escherichia coli HemK, a protein (N5)-glutamine methyltransferase.
Journal of molecular biology 2004;340(4):695-706.
2004: Aiping Dong; Lan Zhou; Xing Zhang; Shawn Stickel; Richard J Roberts; Xiaodong Cheng
Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions.
Biological chemistry 2004;385(5):373-9.
2004: Yu Zheng; Richard J Roberts; Simon Kasif
Segmentally variable genes: a new perspective on adaptation.
PLoS biology 2004;2(4):E81.
2004: Richard J Roberts
Identifying protein function--a call for community action.
PLoS biology 2004;2(3):E42.
2004: Yu Zheng; Richard J Roberts; Simon Kasif
Identification of genes with fast-evolving regions in microbial genomes.
Nucleic acids research 2004;32(21):6347-57.
2003: Tamas Vincze; Janos Posfai; Richard J Roberts
NEBcutter: A program to cleave DNA with restriction enzymes.
Nucleic acids research 2003;31(13):3688-91.
2003: Richard J Roberts; Marlene Belfort; Timothy Bestor; Ashok S Bhagwat; Thomas A Bickle; Jurate Bitinaite; Robert Blumenthal; Sergey Kh Degtyarev; David T F Dryden; Kevin Dybvig; Keith Firman; Elizaveta S Gromova; Richard I Gumport; Stephen E Halford; Stanley Martin Hattman; Joseph Heitman; David P Hornby; Arvydas Janulaitis; Albert Jeltsch; Jytte Josephsen; Antal Kiss; Todd R Klaenhammer; Ichizo Kobayashi; Huimin Kong; Detlev H Krüger; Sanford Lacks; Martin G Marinus; Michiko Miyahara; Richard D Morgan; Noreen E Murray; Valakunja Nagaraja; Andrzej Piekarowicz; Alfred Pingoud; Elisabeth Raleigh; Desirazu N Rao; Norbert Reich; Vladimir Repin; Eric U Selker; Pang-Chui Shaw; Daniel C. Stein; Barry L Stoddard; Waclaw Szybalski; Thomas A Trautner; James L Van Etten; Jorge M B Vitor; Geoffrey G Wilson; Shuang-yong Xu
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
Nucleic acids research 2003;31(7):1805-12.
2003: Richard J Roberts; Tamas Vincze; Janos Posfai; Dana Macelis
REBASE: restriction enzymes and methyltransferases.
Nucleic acids research 2003;31(1):418-20.
2002: Yu Zheng; Richard J Roberts; Simon Kasif
Genomic functional annotation using co-evolution profiles of gene clusters.
Genome biology 2002;3(11):RESEARCH0060.
2002: Qing Xu; Richard D Morgan; Richard J Roberts; Shuang-Yong Xu; Leen-Jan van Doorn; John P Donahue; Geraldine G Miller; Martin Blaser
Functional analysis of iceA1, a CATG-recognizing restriction endonuclease gene in Helicobacter pylori.
Nucleic acids research 2002;30(17):3839-47.
2002: Yu Zheng; Joseph D Szustakowski; Lance Fortnow; Richard J Roberts; Simon Kasif
Computational identification of operons in microbial genomes.
Genome research 2002;12(8):1221-30.
2002: Gun-Do Kim; Jingwei Ni; Nicole Kelesoglu; Richard J Roberts; george feehehery
Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.
The EMBO journal 2002;21(15):4183-95.
2001: Xiaodong Cheng; Richard J Roberts
AdoMet-dependent methylation, DNA methyltransferases and base flipping.
Nucleic acids research 2001;29(18):3784-95.
2001: Albino Bacolla; S Pradhan; Jacquelynn E Larson; Richard J Roberts; Robert D Wells
Recombinant human DNA (cytosine-5) methyltransferase. III. Allosteric control, reaction order, and influence of plasmid topology and triplet repeat length on methylation of the fragile X CGG.CCG sequence.
The Journal of biological chemistry 2001;276(21):18605-13.
2001: Richard J Roberts; Harold Varmus; Michael Ashburner; P O Brown; Michael B Eisen; C Khosla; M Kirschner; R Nusse; M Scott; B Wold
Information access. Building a "GenBank" of the published literature.
Science (New York, N.Y.) 2001;291(5512):2318-9.
2001: L F Lin; Janos Posfai; Richard J Roberts; Huimin Kong
Comparative genomics of the restriction-modification systems in Helicobacter pylori.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2740-5.
2001: K J Arrow; Julius Axelrod; franccesca villella; P Berg; John M Bishop; N Bloembergen; Herbert C Brown; J Cibelli; S Cohen; L N Cooper; E J Corey; J W Cronin; Robert F Curl; R Dulbecco; E H Fischer; V L Fitch; Robert W Fogel; J I Friedman; R F Furchgott; M Gell-Mann; W Gilbert; A Gilman; D Glaser; S L Glashow; R M Green; Paul Greengard; Roger Guillemin; L Hayflick; Herbert A Hauptman; J J Heckman; Alan J Heeger; Dudley R Herschbach; David H Hubel; R Hulse; Eric R Kandel; Jerome Karle; L R Klein; W Kohn; A Kornberg; Edwin G Krebs; R P Lanza; R Laughlin; L Lederman; D M Lee; E Lewis; William N Lipscomb; R A Marcus; D McFadden; RB Merrifield; R Merton; F Modigliani; M J Molina; F Murad; Marshall Nirenberg; D C North; George A Olah; D Osheroff; GE Palade; M Perl; N F Ramsey; B Richter; Richard J Roberts; P A Samuelson; M Schwartz; Phillip A Sharp; Richard E Smalley; Hamilton O Smith; R M Solow; H Stormer; H Taube; R Taylor; ED Thomas; J Tobin; Susumu Tonegawa; C Townes; James D Watson; S Weinberg; T H Weller; M D West; Eric Wieschaus; Torsten N Wiesel; R W Wilson
Nobel laureates' letter to President Bush.
Washington post (Washington, D.C. : 1974) 2001;():A02.
2001: J C Venter; M D Adams; E W Myers; P W Li; R J Mural; G G Sutton; Hamilton O Smith; M Yandell; C A Evans; R A Holt; J D Gocayne; P Amanatides; R M Ballew; D H Huson; Jennifer Wortman; Q Zhang; C D Kodira; X H Zheng; L Chen; M Skupski; G. SUBRAMANIAN; P D Thomas; J Zhang; G L Gabor Miklos; C Nelson; S Broder; andrew clark; J Nadeau; Victor A McKusick; N Zinder; Arnold J Levine; Richard J Roberts; M Simon; C Slayman; M Hunkapiller; R Bolanos; A Delcher; I Dew; D Fasulo; M Flanigan; L Florea; A Halpern; S Hannenhalli; S Kravitz; S Levy; C Mobarry; K Reinert; K Remington; J Abu-Threideh; E Beasley; K Biddick; V Bonazzi; R Brandon; M Cargill; I Chandramouliswaran; R Charlab; K Chaturvedi; Z Deng; V Di Francesco; P Dunn; K Eilbeck; C Evangelista; A E Gabrielian; W Gan; W Ge; F Gong; Z Gu; P Guan; T J Heiman; M E Higgins; R R Ji; Z Ke; K A Ketchum; Z Lai; Y Lei; Z Li; J Li; Y Liang; X Lin; F Lu; G V Merkulov; N Milshina; H M Moore; A K Naik; V A Narayan; B Neelam; D Nusskern; D B Rusch; Steven L Salzberg; W Shao; B Shue; J Sun; Z Wang; A Wang; X Wang; J Wang; M Wei; R Wides; C Xiao; C Yan; A Yao; J Ye; M Zhan; W Zhang; H Zhang; Q Zhao; L Zheng; F Zhong; W Zhong; S Zhu; Shaying Zhao; D Gilbert; S Baumhueter; G Spier; C Carter; A Cravchik; T Woodage; F Ali; H An; A Awe; D Baldwin; H Baden; M Barnstead; I Barrow; K Beeson; D Busam; A Carver; A Center; M L Cheng; L Curry; S Danaher; L Davenport; R Desilets; S Dietz; K Dodson; L Doup; S Ferriera; N Garg; A Gluecksmann; B Hart; J Haynes; C Haynes; C Heiner; S Hladun; Damon Hostin; J Houck; T Howland; C Ibegwam; J Johnson; F Kalush; L Kline; S Koduru; A Love; F Mann; D May; S McCawley; T McIntosh; I McMullen; M Moy; L Moy; B Murphy; K Nelson; C Pfannkoch; E Pratts; V Puri; H Qureshi; M Reardon; R Rodriguez; Y H Rogers; D Romblad; B Ruhfel; R Scott; C Sitter; M Smallwood; E Stewart; R Strong; Edward Suh; R Thomas; N N Tint; S Tse; C Vech; Gaofeng Wang; J Wetter; S Williams; M Williams; S Windsor; E Winn-Deen; K Wolfe; J Zaveri; K Zaveri; Josep F Abril; R Guigó; M J Campbell; K V Sjolander; B Karlak; A Kejariwal; H Mi; B Lazareva; T Hatton; A Narechania; K Diemer; A Muruganujan; N Guo; S Sato; V Bafna; S Istrail; R Lippert; R Schwartz; B Walenz; S Yooseph; D Allen; A Basu; J Baxendale; L Blick; M Caminha; J Carnes-Stine; P Caulk; Y H Chiang; M Coyne; C Dahlke; A Mays; M Dombroski; M Donnelly; D Ely; S Esparham; C Fosler; H Gire; S Glanowski; K Glasser; A Glodek; M Gorokhov; K Graham; B Gropman; M Harris; J Heil; S Henderson; J Hoover; D Jennings; C Jordan; J Jordan; J Kasha; L Kagan; C Kraft; A Levitsky; M Lewis; X Liu; J Lopez; D Ma; W Majoros; J McDaniel; S Murphy; M Newman; T Nguyen; N Nguyen; M Nodell; S Pan; J Peck; M Peterson; W Rowe; R Sanders; J Scott; M Simpson; T Smith; A Sprague; T Stockwell; R Turner; E Venter; M Wang; M Wen; D Wu; M Wu; A Xia; A Zandieh; X Zhu
The sequence of the human genome.
Science (New York, N.Y.) 2001;291(5507):1304-51.
2001: Richard J Roberts
PubMed Central: The GenBank of the published literature.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):381-2.
2001: Richard J Roberts; Dana Macelis
REBASE--restriction enzymes and methylases.
Nucleic acids research 2001;29(1):268-9.
2000: Huimin Kong; L F Lin; N Porter; Shawn Stickel; D Byrd; Janos Posfai; Richard J Roberts
Functional analysis of putative restriction-modification system genes in the Helicobacter pylori J99 genome.
Nucleic acids research 2000;28(17):3216-23.
2000: Qing Xu; Richard D Morgan; Richard J Roberts; Martin Blaser
Identification of type II restriction and modification systems in Helicobacter pylori reveals their substantial diversity among strains.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9671-6.
2000: Qing Xu; Shawn Stickel; Richard J Roberts; Martin Blaser; Richard D Morgan
Purification of the novel endonuclease, Hpy188I, and cloning of its restriction-modification genes reveal evidence of its horizontal transfer to the Helicobacter pylori genome.
The Journal of biological chemistry 2000;275(22):17086-93.
2000: george feehehery; Richard J Roberts
Hybrid mouse-prokaryotic DNA (cytosine-5) methyltransferases retain the specificity of the parental C-terminal domain.
The EMBO journal 2000;19(9):2103-14.
2000: Jean B Margot; AM Aguirre-Arteta; B V Di Giacco; S Pradhan; Richard J Roberts; M Cristina Cardoso; Heinrich Leonhardt
Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure.
Journal of molecular biology 2000;297(2):293-300.
2000: Richard J Roberts
The early days of bioinformatics publishing.
Bioinformatics (Oxford, England) 2000;16(1):2-4.
2000: Richard J Roberts; Dana Macelis
REBASE - restriction enzymes and methylases.
Nucleic acids research 2000;28(1):306-7.
1999: Albino Bacolla; S Pradhan; Richard J Roberts; Robert D Wells
Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated dna.
The Journal of biological chemistry 1999;274(46):33011-9.
1999: S Pradhan; Albino Bacolla; Robert D Wells; Richard J Roberts
Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation.
The Journal of biological chemistry 1999;274(46):33002-10.
1999: Margaret M O'gara; Xing Zhang; Richard J Roberts; Xiaodong Cheng
Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide.
Journal of molecular biology 1999;287(2):201-9.
1999: Richard J Roberts; Dana Macelis
REBASE-restriction enzymes and methylases.
Nucleic acids research 1999;27(1):312-3.
1998: Margaret M O'gara; John Horton; Richard J Roberts; Xiaodong Cheng
Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base.
Nature structural biology 1998;5(10):872-7.
1998: Saulius Serva; Elmar Weinhold; Richard J Roberts; Saulius Klimasauskas
Chemical display of thymine residues flipped out by DNA methyltransferases.
Nucleic acids research 1998;26(15):3473-9.
1998: Richard J Roberts; Xiaodong Cheng
Base flipping.
Annual review of biochemistry 1998;67():181-98.
1998: Richard J Roberts; Dana Macelis
REBASE - restriction enzymes and methylases.
Nucleic acids research 1998;26(1):338-50.
1997: george feehehery; D Talbot; M Sha; J Benner; L Hornstra; E Li; Rudolf Jaenisch; Richard J Roberts
Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase.
Nucleic acids research 1997;25(22):4666-73.
1997: Marlene Belfort; Richard J Roberts
Homing endonucleases: keeping the house in order.
Nucleic acids research 1997;25(17):3379-88.
1997: S Kumar; John Horton; G D Jones; R T Walker; Richard J Roberts; Xiaodong Cheng
DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase.
Nucleic acids research 1997;25(14):2773-83.
1997: Richard J Roberts; Dana Macelis
REBASE-restriction enzymes and methylases.
Nucleic acids research 1997;25(1):248-62.
1996: Margaret M O'gara; Richard J Roberts; Xiaodong Cheng
A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase.
Journal of molecular biology 1996;263(4):597-606.
1996: Margaret M O'gara; Saulius Klimasauskas; Richard J Roberts; Xiaodong Cheng
Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes.
Journal of molecular biology 1996;261(5):634-45.
1996: Richard J Roberts; D Macelis
REBASE--restriction enzymes and methylases.
Nucleic acids research 1996;24(1):223-35.
1995: Richard J Roberts
On base flipping.
Cell 1995;82(1):9-12.
1995: Saulius Klimasauskas; Richard J Roberts
Disruption of the target G-C base-pair by the HhaI methyltransferase.
Gene 1995;157(1-2):163-4.
1995: Saulius Klimasauskas; Richard J Roberts
M.HhaI binds tightly to substrates containing mismatches at the target base.
Nucleic acids research 1995;23(8):1388-95.
1995: S Mi; D Alonso; Richard J Roberts
Functional analysis of Gln-237 mutants of HhaI methyltransferase.
Nucleic acids research 1995;23(4):620-7.
1994: Richard J Roberts; D Macelis
REBASE--restriction enzymes and methylases.
Nucleic acids research 1994;22(17):3628-39.
1994: J Pósfai; Z Száraz; Richard J Roberts
VISA: Visual Sequence Analysis for the comparison of multiple amino acid sequences.
Computer applications in the biosciences : CABIOS 1994;10(5):537-44.
1994: Richard J Roberts
An amazing distortion in DNA induced by a methyltransferase.
Bioscience reports 1994;14(3):103-17.
1994: S Kulakauskas; J M Barsomian; Arvydas Lubys; Richard J Roberts; G G Wilson
Organization and sequence of the HpaII restriction-modification system and adjacent genes.
Gene 1994;142(1):9-15.
1994: Saulius Klimasauskas; S Kumar; Richard J Roberts; Xiaodong Cheng
HhaI methyltransferase flips its target base out of the DNA helix.
Cell 1994;76(2):357-69.
1994: S Kumar; Xiaodong Cheng; Saulius Klimasauskas; S Mi; J Posfai; Richard J Roberts; G G Wilson
The DNA (cytosine-5) methyltransferases.
Nucleic acids research 1994;22(1):1-10.
1993: Xiaodong Cheng; S Kumar; J Posfai; J W Pflugrath; Richard J Roberts
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.
Cell 1993;74(2):299-307.
1993: Richard J Roberts; D Macelis
REBASE--restriction enzymes and methylases.
Nucleic acids research 1993;21(13):3125-37.
1993: S Mi; Richard J Roberts
The DNA binding affinity of HhaI methylase is increased by a single amino acid substitution in the catalytic center.
Nucleic acids research 1993;21(10):2459-64.
1993: Xiaodong Cheng; S Kumar; Saulius Klimasauskas; Richard J Roberts
Crystal structure of the HhaI DNA methyltransferase.
Cold Spring Harbor symposia on quantitative biology 1993;58():331-8.
1992: S Mi; Richard J Roberts
How M.MspI and M.HpaII decide which base to methylate.
Nucleic acids research 1992;20(18):4811-6.
1992: S Kumar; Xiaodong Cheng; J W Pflugrath; Richard J Roberts
Purification, crystallization, and preliminary X-ray diffraction analysis of an M.HhaI-AdoMet complex.
Biochemistry 1992;31(36):8648-53.
1992: A K Dubey; Richard J Roberts
Sequence-specific DNA binding by the MspI DNA methyltransferase.
Nucleic acids research 1992;20(12):3167-73.
1992: J Posfai; Richard J Roberts
Finding errors in DNA sequences.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4698-702.
1992: Richard J Roberts; D Macelis
Restriction enzymes and their isoschizomers.
Nucleic acids research 1992;20 Suppl():2167-80.
1992: A K Dubey; B Mollet; Richard J Roberts
Purification and characterization of the MspI DNA methyltransferase cloned and overexpressed in E. coli.
Nucleic acids research 1992;20(7):1579-85.
1991: Saulius Klimasauskas; J L Nelson; Richard J Roberts
The sequence specificity domain of cytosine-C5 methylases.
Nucleic acids research 1991;19(22):6183-90.
1991: Richard J Roberts; D Macelis
Restriction enzymes and their isoschizomers.
Nucleic acids research 1991;19 Suppl():2077-109.
1990: J M Nelson; S M Miceli; M P Lechevalier; Richard J Roberts
FseI, a new type II restriction endonuclease that recognizes the octanucleotide sequence 5' GGCCGGCC 3'.
Nucleic acids research 1990;18(8):2061-4.
1990: Richard J Roberts
Restriction enzymes and their isoschizomers.
Nucleic acids research 1990;18 Suppl():2331-65.
1990: C O Card; G G Wilson; K Weule; J Hasapes; A Kiss; Richard J Roberts
Cloning and characterization of the HpaII methylase gene.
Nucleic acids research 1990;18(6):1377-83.
1990: Ashok S Bhagwat; B Johnson; K Weule; Richard J Roberts
Primary sequence of the EcoRII endonuclease and properties of its fusions with beta-galactosidase.
The Journal of biological chemistry 1990;265(2):767-73.
1989: G C Conway; Adrian R Krainer; David L Spector; Richard J Roberts
Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing.
Molecular and cellular biology 1989;9(12):5273-80.
1989: L Hamablet; G C Chen; A Brown; Richard J Roberts
LpnI, from Legionella pneumophila, is a neoschizomer of HaeII.
Nucleic acids research 1989;17(15):6417.
1989: P M Lin; C H Lee; Richard J Roberts
Cloning and characterization of the genes encoding the MspI restriction modification system.
Nucleic acids research 1989;17(8):3001-11.
1989: J Pósfai; Ashok S Bhagwat; G Pósfai; Richard J Roberts
Predictive motifs derived from cytosine methyltransferases.
Nucleic acids research 1989;17(7):2421-35.
1989: Richard J Roberts
Restriction enzymes and their isoschizomers.
Nucleic acids research 1989;17 Suppl():r347-87.
1988: J Pósfai; Ashok S Bhagwat; Richard J Roberts
Sequence motifs specific for cytosine methyltransferases.
Gene 1988;74(1):261-5.
1988: Richard J Roberts
Restriction enzymes and their isoschizomers.
Nucleic acids research 1988;16 Suppl():r271-313.
1987: Ashok S Bhagwat; Richard J Roberts
Genetic analysis of the 5-azacytidine sensitivity of Escherichia coli K-12.
Journal of bacteriology 1987;169(4):1537-46.
1987: B Zerler; Richard J Roberts; M B Mathews; Elizabeth Moran
Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products.
Molecular and cellular biology 1987;7(2):821-9.
1987: Richard J Roberts
Restriction enzymes and their isoschizomers.
Nucleic acids research 1987;15 Suppl():r189-217.
1987: Richard J Roberts
Restriction and modification enzymes and their recognition sequences.
Gene amplification and analysis 1987;5():1-49.
1986: Ashok S Bhagwat; anjum sohail; Richard J Roberts
Cloning and characterization of the dcm locus of Escherichia coli K-12.
Journal of bacteriology 1986;166(3):751-5.
1986: Elizabeth Moran; T Grodzicker; Richard J Roberts; M B Mathews; B Zerler
Lytic and transforming functions of individual products of the adenovirus E1A gene.
Journal of virology 1986;57(3):765-75.
1985: A Kiss; G Posfai; C C Keller; P Venetianer; Richard J Roberts
Nucleotide sequence of the BsuRI restriction-modification system.
Nucleic acids research 1985;13(18):6403-21.
1985: Richard J Roberts
Restriction and modification enzymes and their recognition sequences.
Nucleic acids research 1985;13 Suppl():r165-200.
1984: G A Freyer; Y Katoh; Richard J Roberts
Characterization of the major mRNAs from adenovirus 2 early region 4 by cDNA cloning and sequencing.
Nucleic acids research 1984;12(8):3503-19.
1984: C Keller; M Corcoran; Richard J Roberts
Computer programs for handling nucleic acid sequences.
Nucleic acids research 1984;12(1 Pt 1):379-86.
1984: Richard J Roberts
Restriction and modification enzymes and their recognition sequences.
Nucleic acids research 1984;12 Suppl():r167-204.
1983: Richard J Roberts
Restriction and modification enzymes and their recognition sequences.
Nucleic acids research 1983;11(1):r135-67.
1983: Richard J Roberts; D Sciaky; R E Gelinas; B D Jiang; C E Yen; M M Kelly; P A Bullock; B L Parsons; K E O'Neill; Thomas Gingeras
Information content of the adenovirus-2 genome.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 2():1025-37.
1982: Thomas Gingeras; D Sciaky; R E Gelinas; J Bing-Dong; C E Yen; M M Kelly; P A Bullock; B L Parsons; K E O'Neill; Richard J Roberts
Nucleotide sequences from the adenovirus-2 genome.
The Journal of biological chemistry 1982;257(22):13475-91.
1982: Richard J Roberts
Restriction and modification enzymes and their recognition sequences.
Nucleic acids research 1982;10(5):r117-44.
1982: J E Brooks; Richard J Roberts
Modification profiles of bacterial genomes.
Nucleic acids research 1982;10(3):913-34.
1981: Thomas Gingeras; L Greenough; Schildkraut Ira; Richard J Roberts
Two new restriction endonucleases from Proteus vulgaris.
Nucleic acids research 1981;9(18):4525-36.
1981: Richard J Roberts
Restriction and modification enzymes and their recognition sequences.
Nucleic acids research 1981;9(1):r75-96.
1980: Thomas Gingeras; Richard J Roberts
Steps toward computer analysis of nucleotide sequences.
Science (New York, N.Y.) 1980;209(4463):1322-8.
1980: Richard J Roberts
Restriction and modification enzymes and their recognition sequences.
Gene 1980;8(4):329-43.
1980: Richard J Roberts
Restriction and modification enzymes and their recognition sequences.
Nucleic acids research 1980;8(1):r63-r80.
1980: Richard J Roberts
Directory of restriction endonucleases.
Methods in enzymology 1980;65(1):1-15.
1979: A H Rosenberg; M N Simon; F W Studier; Richard J Roberts
Survey and mapping of restriction endonuclease cleavage sites in bacteriophage T7 DNA.
Journal of molecular biology 1979;135(4):907-15.
1979: Thomas Gingeras; J P Milazzo; D Sciaky; Richard J Roberts
Computer programs for the assembly of DNA sequences.
Nucleic acids research 1979;7(2):529-45.
1979: B S Zain; Richard J Roberts
Sequences from the beginning of the fiber messenger RNA of adenovirus-2.
Journal of molecular biology 1979;131(2):341-52.
1979: S Zain; J Sambrook; Richard J Roberts; W Keller; M Fried; A R Dunn
Nucleotide sequence analysis of the leader segments in a cloned copy of adenovirus 2 fiber mRNA.
Cell 1979;16(4):851-61.
1979: J R Arrand; Richard J Roberts
The nucleotide sequences at the termini of adenovirus-2 DNA.
Journal of molecular biology 1979;128(4):577-94.
1979: Richard J Roberts
Directory of restriction endonucleases.
Methods in enzymology 1979;68():27-41.
1978: Thomas Gingeras; J P MIlazzo; Richard J Roberts
A computer assisted method for the determination of restriction enzyme recognifion sites.
Nucleic acids research 1978;5(11):4105-27.
1978: Richard J Roberts
Restriction and modification enzymes and their recognition sequences.
Gene 1978;4(3):183-94.
1978: J Tomassini; R Roychoudhury; R Wu; Richard J Roberts
Recognition sequence of restriction endonuclease KpnI from Klebsiella pneumoniae.
Nucleic acids research 1978;5(11):4055-64.
1978: B S Zain; Richard J Roberts
Characterization and sequence analysis of a recombination site in the hybrid virus Ad2+ND.
Journal of molecular biology 1978;120(1):13-31.
1978: Richard J Roberts
Restriction endonucleases: a new role in vivo?
Nature 1978;271(5645):502.
1978: Thomas Gingeras; P A Myers; J A Olson; F A Hanberg; Richard J Roberts
A new specific endonuclease present in Xanthomonas holcicola, Xanthomonas papavericola and Brevibacterium luteum.
Journal of molecular biology 1978;118(1):113-22.
1978: J R Arrand; P A Myers; Richard J Roberts
A new restriction endonuclease from Streptomyces albus G.
Journal of molecular biology 1978;118(1):127-35.
1977: B S Zain; Richard J Roberts
A new specific endonuclease from Xanthomonas badrii.
Journal of molecular biology 1977;115(2):249-55.
1977: D Kamp; R Kahmann; D Zipser; Richard J Roberts
Mapping of restriction sites in the attachment site region of bacteriophage lambda.
Molecular & general genetics : MGG 1977;154(3):231-48.
1977: L T Chow; R E Gelinas; T R Broker; Richard J Roberts
An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.
Cell 1977;12(1):1-8.
1977: R E Gelinas; P A Myers; G H Weiss; Richard J Roberts; K Murray
A specific endonuclease from Brevibacterium albidum.
Journal of molecular biology 1977;114(3):433-40.
1977: R E Gelinas; P A Myers; Richard J Roberts
Two sequence-specific endonucleases from Moraxella bovis.
Journal of molecular biology 1977;114(1):169-79.
1977: R E Gelinas; Richard J Roberts
One predominant 5'-undecanucleotide in adenovirus 2 late messenger RNAs.
Cell 1977;11(3):533-44.
1977: W G Burton; Richard J Roberts; P A Myers; R Sager
A site-specific single-strand endonuclease from the eukaryote Chlamydomonas.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(7):2687-91.
1977: S A Endow; Richard J Roberts
Two restriction-like enzymes from Xanthomonas malvacearum.
Journal of molecular biology 1977;112(3):521-9.
1977: K N Subramanian; B S Zain; Richard J Roberts; S M Weissman
Mapping of the HhaI and HinfI cleavage sites on simian virus 40 DNA.
Journal of molecular biology 1977;110(2):297-317.
1977: M Wu; Richard J Roberts; N Davidson
Structure of the inverted terminal repetition of adenovirus type 2 DNA.
Journal of virology 1977;21(2):766-77.
1977: Richard J Roberts; G A Wilson; F E Young
Recognition sequence of specific endonuclease BamH.I from Bacillus amyloliquefaciens H.
Nature 1977;265(5589):82-4.
1976: Richard J Roberts
Restriction endonucleases.
CRC critical reviews in biochemistry 1976;4(2):123-64.
1976: Richard J Roberts; P A Myers; A Morrison; K Murray
A specific endonuclease from Haemophilus haemolyticus.
Journal of molecular biology 1976;103(1):199-208.
1976: Richard J Roberts; P A Myers; A Morrison; K Murray
A specific endonuclease from Arthrobacter luteus.
Journal of molecular biology 1976;102(1):157-65.
1975: P H Steenbergh; J S Sussenbach; Richard J Roberts; H S Jansz
The 3'-terminal nucleotide sequences of adenovirus types 2 and 5 DNA.
Journal of virology 1975;15(2):268-72.
1975: C Mulder; J R Arrand; H Delius; W Keller; U Pettersson; Richard J Roberts; Phillip A Sharp
Cleavage maps of DNA from adenovirus types 2 and 5 by restriction endonucleases EcoRI and HpaI.
Cold Spring Harbor symposia on quantitative biology 1975;39 Pt 1():397-400.
1974: Richard J Roberts; J R Arrand; W Keller
The length of the terminal repetition in adenovirus-2 DNA.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(10):3829-33.
1974: B Allet; Richard J Roberts; R F Gesteland; R Solem
Class of promotor sites for Escherichia coli DNA-dependent RNA polymerase.
Nature 1974;249(454):217-21.