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David Robertson

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Paul J Gilligan; Liqi He; Todd Clarke; Parcharee Tivitmahaisoon; Snjezana Lelas; Yu-Wen Li; Karen Heman; Lawrence Fitzgerald; Keith Miller; Ge Zhang; Anne Marshall; Carol Krause; John F McElroy; Kathyrn Ward; Helen Shen; Harvey Wong; Scott Grossman; Gregory Nemeth; Robert Zaczek; Stephen P Arneric; Paul R Hartig; David W Robertson; George Trainor
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.
Michael G Yang; Jian-Liang Shi; Dilip P Modi; Jennifer Wells; Brian M Cochran; Mark A Wolf; Lorin A Thompson; Mercy M Ramanjulu; Arthur H Roach; Robert Zaczek; David W Robertson; Ruth R Wexler; Richard E Olson
Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent gamma-secretase inhibitors.
Lorin A Thompson; Ann Y Liauw; Mercy M Ramanjulu; Padmaja Kasireddy-Polam; Stephen E Mercer; Thomas Maduskuie; Marcie Glicksman; Arthur H Roach; Jere E Meredith; Rui-Qin Liu; Andrew P Combs; Jeffrey N Higaki; Barbara Cordell; Dietmar Seiffert; Robert Zaczek; David W Robertson; Richard E Olson
Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.

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All Publications

2009: Paul J Gilligan; Liqi He; Todd Clarke; Parcharee Tivitmahaisoon; Snjezana Lelas; Yu-Wen Li; Karen Heman; Lawrence Fitzgerald; Keith Miller; Ge Zhang; Anne Marshall; Carol Krause; John F McElroy; Kathyrn Ward; Helen Shen; Harvey Wong; Scott Grossman; Gregory Nemeth; Robert Zaczek; Stephen P Arneric; Paul R Hartig; David W Robertson; George Trainor
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.
Journal of medicinal chemistry 2009;52(9):3073-83.
2007: Michael G Yang; Jian-Liang Shi; Dilip P Modi; Jennifer Wells; Brian M Cochran; Mark A Wolf; Lorin A Thompson; Mercy M Ramanjulu; Arthur H Roach; Robert Zaczek; David W Robertson; Ruth R Wexler; Richard E Olson
Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent gamma-secretase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(14):3910-5.
2006: Lorin A Thompson; Ann Y Liauw; Mercy M Ramanjulu; Padmaja Kasireddy-Polam; Stephen E Mercer; Thomas Maduskuie; Marcie Glicksman; Arthur H Roach; Jere E Meredith; Rui-Qin Liu; Andrew P Combs; Jeffrey N Higaki; Barbara Cordell; Dietmar Seiffert; Robert Zaczek; David W Robertson; Richard E Olson
Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(9):2357-63.
2004: Snjezana Lelas; Harvey Wong; Yu-Wen Li; Karen L Heman; Kathryn A Ward; Kim L Zeller; Kristine K Sieracki; Joseph L Polino; Helen E Godonis; Shelly X Ren; Xiao-Xin Yan; Stephen P Arneric; David W Robertson; Paul R Hartig; Scott Grossman; George L Trainor; Rebecca A Taub; Robert Zaczek; Paul J Gilligan; John F McElroy
Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats.
The Journal of pharmacology and experimental therapeutics 2004;309(1):293-302.
2003: Taekyu Lee; Albert J Robichaud; Kristopher E Boyle; Yimin Lu; David W Robertson; Keith J Miller; Lawrence W Fitzgerald; John F McElroy; Brian L Largent
Novel, highly potent, selective 5-HT2A/D2 receptor antagonists as potential atypical antipsychotics.
Bioorganic & medicinal chemistry letters 2003;13(4):767-70.
2003: Argyrios G Arvanitis; Charles R Arnold; Lawrence W Fitzgerald; William E Frietze; Richard E Olson; Paul J Gilligan; David W Robertson
CRF ligands via Suzuki and Negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine.
Bioorganic & medicinal chemistry letters 2003;13(2):289-91.
2003: Argyrios G Arvanitis; Joseph T Rescinito; Charles R Arnold; Richard G Wilde; Lawrence W Fitzgerald; Robert Zaczek; Paul R Hartig; Scott Grossman; Stephen P Arneric; Paul J Gilligan; Richard E Olson; David W Robertson
Imidazo[4,5-c]pyridines as corticotropin releasing factor receptor ligands.
Bioorganic & medicinal chemistry letters 2003;13(1):129-31.
2003: Argyrios G Arvanitis; Joseph T Rescinito; Charles R Arnold; Richard G Wilde; Gary A Cain; Jung-Hui Sun; Jia-Sheng Yan; Christopher A Teleha; Lawrence W Fitzgerald; John F McElroy; Robert Zaczek; Paul R Hartig; Scott Grossman; Stephen P Arneric; Paul J Gilligan; Richard E Olson; David W Robertson
Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands.
Bioorganic & medicinal chemistry letters 2003;13(1):125-8.
2002: Xiao-Yi Xiao; Rongshi Li; David Hurst; Hui Zhuang; Shuhao Shi; Anthony W Czarnik; Albert J Robichaud; Dean A Wacker; David W Robertson
Solid-phase synthesis of alkyl aryl ethers via the Ullmann condensation.
Journal of combinatorial chemistry 2002;4(5):536-9.
2000: Dietmar Seiffert; Jodi D Bradley; Cynthia M Rominger; David H Rominger; F Yang; Jere E Meredith; Qian Wang; Arthur H Roach; Lorin A Thompson; Susan M Spitz; Jeffrey N Higaki; Shimoga R Prakash; Andrew P Combs; Robert Copeland; Stephen P Arneric; Paul R Hartig; David W Robertson; Barbara Cordell; Andrew M Stern; Richard E Olson; Robert Zaczek
Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors.
The Journal of biological chemistry 2000;275(44):34086-91.
2000: Paul J Gilligan; David W Robertson; Robert Zaczek
Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents.
Journal of medicinal chemistry 2000;43(9):1641-60.
2000: Paul J Gilligan; C Baldauf; AJ Cocuzza; DR Chidester; Robert Zaczek; Lawrence W Fitzgerald; John F McElroy; Mark A Smith; H S Shen; JA Saye; D Christ; George L Trainor; David W Robertson; Paul R Hartig
The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonist.
Bioorganic & medicinal chemistry 2000;8(1):181-9.
2000: Lawrence W Fitzgerald; Timothy C Burn; B S Brown; JP Patterson; M H Corjay; P A Valentine; Jung-Hui Sun; John R Link; I Abbaszade; JM Hollis; Brian L Largent; Paul R Hartig; Gregory F Hollis; P C Meunier; Albert J Robichaud; David W Robertson
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
Molecular pharmacology 2000;57(1):75-81.