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Alexander Robling

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TOP 3
Alexander G Robling
The expanding role of Wnt signaling in bone metabolism.
Stuart J Warden; Rachel C Dirks; Matthew R Galley; Lydia A George; Elizabeth A Guildenbecher; Ashley M Judd; Jeffrey S Richard; Alexander G Robling; Robyn K Fuchs
Reduced gravitational loading does not account for the skeletal effect of botulinum toxin-induced muscle inhibition suggesting a direct effect of muscle on bone.
Liming Zhao; Todd R Dodge; Alexander G Robling; Joon W Shim; Hiroki Yokota
Inactivation of Lrp5 in osteocytes reduces young's modulus and responsiveness to the mechanical loading.

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All Publications

2013: Alexander G Robling
The expanding role of Wnt signaling in bone metabolism.
Bone 2013;55(1):256-7.
2013: Stuart J Warden; Rachel C Dirks; Matthew R Galley; Lydia A George; Elizabeth A Guildenbecher; Ashley M Judd; Jeffrey S Richard; Alexander G Robling; Robyn K Fuchs
Reduced gravitational loading does not account for the skeletal effect of botulinum toxin-induced muscle inhibition suggesting a direct effect of muscle on bone.
Bone 2013;54(1):98-105.
2013: Liming Zhao; Todd R Dodge; Alexander G Robling; Joon W Shim; Hiroki Yokota
Inactivation of Lrp5 in osteocytes reduces young's modulus and responsiveness to the mechanical loading.
Bone 2013;54(1):35-43.
2012: Todd Dodge; Alexander G Robling; Mina Wanis; Nelson B Watts; Ozan Akkus; Ramez Ayoub; Amit Bhattacharya; Liming Zhao; Hiroki Yokota
Mechanical loading, damping, and load-driven bone formation in mouse tibiae.
Bone 2012;51(4):810-8.
2012: Paul J Niziolek; Matthew L Warman; Alexander G Robling
Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner.
Bone 2012;51(3):459-65.
2012: Alexander G Robling
The interaction of biological factors with mechanical signals in bone adaptation: recent developments.
Current osteoporosis reports 2012;10(2):126-31.
2012: Marta B Alvarez; Paul Childress; Rita Gerard-O'Riley; Michael Hanlon; Brittney-Shea Herbert; Fredrick M Pavalko; Binu K Philip; Alexander G Robling; Joseph P Bidwell
Immortalization and characterization of osteoblast cell lines generated from wild-type and Nmp4-null mouse bone marrow stromal cells using murine telomerase reverse transcriptase (mTERT).
Journal of cellular physiology 2012;227(5):1873-82.
2011: Emily G Farrow; James C Fleet; Holly J Garringer; Charles B Goodwin; Siu L Hui; Victoria Jideonwo; Martin J Magers; Munro Peacock; Alexander G Robling; Keith R Stayrook; Lelia J Summers; Ruben Vidal; Matthew R Allen; Rebecca J Chan; Siobhan I Davis; Xijie Yu; Kenneth E White
Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(46):E1146-55.
2011: Paul J Niziolek; Yajun Cui; Takeisha L Farmer; Charles H Turner; Matthew L Warman; Alexander G Robling
High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes.
Bone 2011;49(5):1010-9.
2011: Alexander G Robling; Teresita Bellido; Joseph P Bidwell; Paul J Childress; Shana N Ellis; Rajendra Kedlaya; Charles H Turner
Anabolic and catabolic regimens of human parathyroid hormone 1-34 elicit bone- and envelope-specific attenuation of skeletal effects in Sost-deficient mice.
Endocrinology 2011;152(8):2963-75.
2011: Paul Childress; Aaron Heller; Melissa A Kacena; Binu K Philip; Lilian I Plotkin; Alexander G Robling; Nicoletta Bivi; Angela Bruzzaniti; Joseph P Bidwell
Nmp4/CIZ suppresses the response of bone to anabolic parathyroid hormone by regulating both osteoblasts and osteoclasts.
Calcified tissue international 2011;89(1):74-89.
2011: Xiaohua Wu; Xianlin Yang; Shi Chen; D Wade Clapp; Simon J Conway; Theresa A Guise; Yongzheng He; Li Jiang; Xiaohong Li; Khalid S Mohammad; Grzegorz Nalepa; Steven D Rhodes; Alexander G Robling; Paige Snider; Feng-Chun Yang
The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1.
PloS one 2011;6(9):e24917.
2010: Binu K Philip; Paul J Childress; Alexander G Robling; Aaron Heller; Peter P Nawroth; Angelika Bierhaus; Joseph P Bidwell
RAGE supports parathyroid hormone-induced gains in femoral trabecular bone.
American journal of physiology. Endocrinology and metabolism 2010;298(3):E714-25.
2010: Alexander G Robling
Muscle loss and bone loss: master and slave?
Bone 2010;46(2):272-3.
2010: Paul Childress; Alexander G Robling; Joseph P Bidwell
Nmp4/CIZ: road block at the intersection of PTH and load.
Bone 2010;46(2):259-66.
2010: Stuart J Warden; Alexander G Robling; Elizabeth M Haney; Charles H Turner; Michael M Bliziotes
The emerging role of serotonin (5-hydroxytryptamine) in the skeleton and its mediation of the skeletal effects of low-density lipoprotein receptor-related protein 5 (LRP5).
Bone 2010;46(1):4-12.
2009: Alexander G Robling
Is bone's response to mechanical signals dominated by muscle forces?
Medicine and science in sports and exercise 2009;41(11):2044-9.
2009: Vincent H Gattone; Rachel M Sinders; Troy A Hornberger; Alexander G Robling
Late progression of renal pathology and cyst enlargement is reduced by rapamycin in a mouse model of nephronophthisis.
Kidney international 2009;76(2):178-82.
2009: Alexander G Robling; Paul Childress; Jun Yu; Jessica Cotte; Aaron Heller; Binu K Philip; Joseph P Bidwell
Nmp4/CIZ suppresses parathyroid hormone-induced increases in trabecular bone.
Journal of cellular physiology 2009;219(3):734-43.
2009: Alexander G Robling; Charles H Turner
Mechanical signaling for bone modeling and remodeling.
Critical reviews in eukaryotic gene expression 2009;19(4):319-38.
2009: Charles H Turner; Stuart J Warden; Teresita Bellido; Lilian I Plotkin; Natarajan Kumar; Iwona Jasiuk; Jon Danzig; Alexander G Robling
Mechanobiology of the skeleton.
Science signaling 2009;2(68):pt3.
2008: Veerendra Munugalavadla; Sasidhar Vemula; Emily Catherine Sims; Subha Krishnan; Shi Chen; Jincheng Yan; Huijie Li; Paul J Niziolek; Clifford M Takemoto; Alexander G Robling; Feng-Chun Yang; Reuben Kapur
The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration.
Molecular and cellular biology 2008;28(23):7182-98.
2008: Joseph P Bidwell; Jieping Yang; Alexander G Robling
Is HMGB1 an osteocyte alarmin?
Journal of cellular biochemistry 2008;103(6):1671-80.
2008: Jincheng Yan; Shi Chen; Yingze Zhang; Xiaohong Li; Yan Li; Xiaohua Wu; Jin Yuan; Alexander G Robling; Reuben Kapur; Reuben Karpur; Rebecca J Chan; Feng-Chun Yang
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Human molecular genetics 2008;17(7):936-48.
2008: Jieping Yang; Rita Shah; Alexander G Robling; Evan Templeton; Huan Yang; Kevin Tracey; Joseph P Bidwell
HMGB1 is a bone-active cytokine.
Journal of cellular physiology 2008;214(3):730-9.
2008: Alexander G Robling; Paul J Niziolek; Lee A Baldridge; Keith W Condon; Matthew R Allen; Imranul Alam; Sara M Mantila; Jelica Gluhak-Heinrich; Teresita M Bellido; Stephen E Harris; Charles H Turner
Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin.
The Journal of biological chemistry 2008;283(9):5866-75.
2008: Charles A O'Brien; Lilian Plotkin; Carlo Galli; Joseph J Goellner; Arancha R Gortazar; Matthew R Allen; Alexander G Robling; Mary L Bouxsein; Ernestina Schipani; Charles H Turner; Robert L Jilka; Robert S Weinstein; Stavros C Manolagas; Teresita Bellido
Control of bone mass and remodeling by PTH receptor signaling in osteocytes.
PloS one 2008;3(8):e2942.
2007: Kanokwan charoonpatrapong Panyayong; Rita Shah; Jieping Yang; Marta Alvarez; Fredrick M Pavalko; Rita Gerard-O'Riley; Alexander G Robling; Evan Templeton; Joseph P Bidwell
Nmp4/CIZ contributes to fluid shear stress induced MMP-13 gene induction in osteoblasts.
Journal of cellular biochemistry 2007;102(5):1202-13.
2007: Stephen E Harris; Jelica Gluhak-Heinrich; Marie A Harris; Wuchen Yang; Lynda F Bonewald; D Riha; Peter S N Rowe; Alexander G Robling; C H Turner; Jian Q Feng; Marc McKee; D Nicollela
DMP1 and MEPE expression are elevated in osteocytes after mechanical loading in vivo: theoretical role in controlling mineral quality in the perilacunar matrix.
Journal of musculoskeletal & neuronal interactions 2007;7(4):313-5.
2007: Leanne Saxon; Alexander G Robling; Alesha B Castillo; S Mohan; Charles H Turner
The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta.
American journal of physiology. Endocrinology and metabolism 2007;293(2):E484-91.
2007: Alexander G Robling; Stuart J Warden; Kathryn L Shultz; Wesley G Beamer; Charles H Turner
Genetic effects on bone mechanotransduction in congenic mice harboring bone size and strength quantitative trait loci.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(7):984-91.
2006: Feng-Chun Yang; Shi Chen; Alexander G Robling; Xijie Yu; Todd D Nebesio; Jincheng Yan; Trent Morgan; Xiaohong Li; Jin Yuan; Janet Hock; David A Ingram; D Wade Clapp
Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions.
The Journal of clinical investigation 2006;116(11):2880-91.
2006: Alexander G Robling; T Bellido; Charles H Turner
Mechanical stimulation in vivo reduces osteocyte expression of sclerostin.
Journal of musculoskeletal & neuronal interactions 2006;6(4):354.
2006: Kimihiko Sawakami; Alexander G Robling; Minrong Ai; Nathaniel D Pitner; Dawei Liu; Stuart J Warden; Jiliang Li; Peter Maye; David W Rowe; Randall L Duncan; Matthew L Warman; Charles H Turner
The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment.
The Journal of biological chemistry 2006;281(33):23698-711.
2006: Kanokwan charoonpatrapong Panyayong; Rita Shah; Alexander G Robling; Marta Alvarez; D Wade Clapp; Shi Chen; Ryan P Kopp; Fredrick M Pavalko; Jun Yu; Joseph P Bidwell
HMGB1 expression and release by bone cells.
Journal of cellular physiology 2006;207(2):480-90.
2006: Alexander G Robling; Alesha B Castillo; Charles H Turner
Biomechanical and molecular regulation of bone remodeling.
Annual review of biomedical engineering 2006;8():455-98.
2005: Imranul Alam; Alexander G Robling; Sarah Weissing; Lucinda G Carr; Lawrence Lumeng; Charles H Turner
Bone mass and strength: phenotypic and genetic relationship to alcohol preference in P/NP and HAD/LAD rats.
Alcoholism, clinical and experimental research 2005;29(10):1769-76.
2005: Jennifer L Schriefer; Stuart J Warden; Leanne Saxon; Alexander G Robling; Charles H Turner
Cellular accommodation and the response of bone to mechanical loading.
Journal of biomechanics 2005;38(9):1838-45.
2005: Wuchen Yang; Yongbo Lu; Ivo Kalajzic; Dayong Guo; Marie A Harris; Jelica Gluhak-Heinrich; Shiva Kotha; Lynda F Bonewald; Jian Q Feng; David W Rowe; Charles H Turner; Alexander G Robling; Stephen E Harris
Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo.
The Journal of biological chemistry 2005;280(21):20680-90.
2005: Leanne Saxon; Alexander G Robling; Imranul Alam; Charles H Turner
Mechanosensitivity of the rat skeleton decreases after a long period of loading, but is improved with time off.
Bone 2005;36(3):454-64.
2005: Imranul Alam; Stuart J Warden; Alexander G Robling; Charles H Turner
Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(3):438-46.
2005: Jennifer L Schriefer; Alexander G Robling; Stuart J Warden; Adam J Fournier; James Mason; Charles H Turner
A comparison of mechanical properties derived from multiple skeletal sites in mice.
Journal of biomechanics 2005;38(3):467-75.
2005: Stuart J Warden; Alexander G Robling; Megan S Sanders; Michael M Bliziotes; Charles H Turner
Inhibition of the serotonin (5-hydroxytryptamine) transporter reduces bone accrual during growth.
Endocrinology 2005;146(2):685-93.
2005: Charles H Turner; Alexander G Robling
Mechanisms by which exercise improves bone strength.
Journal of bone and mineral metabolism 2005;23 Suppl():16-22.
2004: Charles H Turner; Alexander G Robling
Exercise as an anabolic stimulus for bone.
Current pharmaceutical design 2004;10(21):2629-41.
2003: Alexander G Robling; Jiliang Li; Kathryn L Shultz; Wesley G Beamer; Charles H Turner
Evidence for a skeletal mechanosensitivity gene on mouse chromosome 4.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):324-6.
2003: Charles H Turner; Alexander G Robling
Designing exercise regimens to increase bone strength.
Exercise and sport sciences reviews 2003;31(1):45-50.
2002: Alexander G Robling; Charles H Turner
Mechanotransduction in bone: genetic effects on mechanosensitivity in mice.
Bone 2002;31(5):562-9.
2002: Alexander G Robling; Felicia M Hinant; David B Burr; Charles H Turner
Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(8):1545-54.
2002: Charles H Turner; Alexander G Robling; Randall L Duncan; David B Burr
Do bone cells behave like a neuronal network?
Calcified tissue international 2002;70(6):435-42.
2002: David B Burr; Alexander G Robling; Charles H Turner
Effects of biomechanical stress on bones in animals.
Bone 2002;30(5):781-6.
2002: Alexander G Robling; Felecia M Hinant; David B Burr; Charles H Turner
Shorter, more frequent mechanical loading sessions enhance bone mass.
Medicine and science in sports and exercise 2002;34(2):196-202.
2002: Naoko Ohashi; Alexander G Robling; David B Burr; Charles H Turner
The effects of dynamic axial loading on the rat growth plate.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(2):284-92.
2001: YF Hsieh; Alexander G Robling; Walter T Ambrosius; David B Burr; Charles H Turner
Mechanical loading of diaphyseal bone in vivo: the strain threshold for an osteogenic response varies with location.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(12):2291-7.
2001: Alexander G Robling; D B Burr; C H Turner
Recovery periods restore mechanosensitivity to dynamically loaded bone.
The Journal of experimental biology 2001;204(Pt 19):3389-99.
2001: Alexander G Robling; K M Duijvelaar; J V Geevers; Naoko Ohashi; Charles H Turner
Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force.
Bone 2001;29(2):105-13.
2001: Alexander G Robling; DB Burr; Charles H Turner
Skeletal loading in animals.
Journal of musculoskeletal & neuronal interactions 2001;1(3):249-62.
2000: Alexander G Robling; David B Burr; Charles H Turner
Partitioning a daily mechanical stimulus into discrete loading bouts improves the osteogenic response to loading.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(8):1596-602.