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Thomas Roche

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TOP 3
Yasuaki Hiromasa; Xiaohua Yan; Thomas E Roche
Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r.
Yasuaki Hiromasa; Thomas E Roche
Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2.
Xuekui Yu; Yasuaki Hiromasa; Hua Tsen; James K Stoops; Thomas E Roche; Z Hong Zhou
Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains.

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All Publications

2008: Yasuaki Hiromasa; Xiaohua Yan; Thomas E Roche
Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r.
Biochemistry 2008;47(8):2312-24.
2008: Yasuaki Hiromasa; Thomas E Roche
Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2.
Biochemistry 2008;47(8):2298-311.
2008: Xuekui Yu; Yasuaki Hiromasa; Hua Tsen; James K Stoops; Thomas E Roche; Z Hong Zhou
Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains.
Structure (London, England : 1993) 2008;16(1):104-14.
2007: Thomas E Roche; Yasuaki Hiromasa
Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer.
Cellular and molecular life sciences : CMLS 2007;64(7-8):830-49.
2006: Yasuaki Hiromasa; Liangyan Hu; Thomas E Roche
Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
The Journal of biological chemistry 2006;281(18):12568-79.
2006: Thorsten R Knoechel; Alec D Tucker; Colin M Robinson; Chris Phillips; Wendy Taylor; Peter J Bungay; Shane A Kasten; Thomas E Roche; David G Brown
Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.
Biochemistry 2006;45(2):402-15.
2004: Ali Turkan; Yasuaki Hiromasa; Thomas E Roche
Formation of a complex of the catalytic subunit of pyruvate dehydrogenase phosphatase isoform 1 (PDP1c) and the L2 domain forms a Ca2+ binding site and captures PDP1c as a monomer.
Biochemistry 2004;43(47):15073-85.
2004: Haiying Bao; Shane A Kasten; Xiaohua Yan; Yasuaki Hiromasa; Thomas E Roche
Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.
Biochemistry 2004;43(42):13442-51.
2004: Haiying Bao; Shane A Kasten; Xiaohua Yan; Thomas E Roche
Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.
Biochemistry 2004;43(42):13432-41.
2004: Yasuaki Hiromasa; Tetsuro Fujisawa; Yoichi Aso; Thomas E Roche
Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.
The Journal of biological chemistry 2004;279(8):6921-33.
2003: Yasuaki Hiromasa; Thomas E Roche
Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase.
The Journal of biological chemistry 2003;278(36):33681-93.
2003: Thomas E Roche; Yasuaki Hiromasa; Ali Turkan; Xiaoming Gong; Tao Peng; Xiaohua Yan; Shane A Kasten; Haiying Bao; Jianchun Dong
Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.
European journal of biochemistry / FEBS 2003;270(6):1050-6.
2002: Ali Turkan; Xiaoming Gong; Tao Peng; Thomas E Roche
Structural requirements within the lipoyl domain for the Ca2+-dependent binding and activation of pyruvate dehydrogenase phosphatase isoform 1 or its catalytic subunit.
The Journal of biological chemistry 2002;277(17):14976-85.
2001: S Liu; Xiaoming Gong; Xiaohua Yan; Tao Peng; John C Baker; L Li; P M Robben; S Ravindran; L A Andersson; A B Cole; Thomas E Roche
Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.
Archives of biochemistry and biophysics 2001;386(2):123-35.
2001: Thomas E Roche; John C Baker; Xiaohua Yan; Yasuaki Hiromasa; Xiaoming Gong; Tao Peng; J Dong; Ali Turkan; Shane A Kasten
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms.
Progress in nucleic acid research and molecular biology 2001;70():33-75.
2000: John C Baker; Xiaohua Yan; Tao Peng; Shane A Kasten; Thomas E Roche
Marked differences between two isoforms of human pyruvate dehydrogenase kinase.
The Journal of biological chemistry 2000;275(21):15773-81.
2000: Xiaoming Gong; Tao Peng; A Yakhnin; Michal Zolkiewski; J Quinn; S J Yeaman; Thomas E Roche
Specificity determinants for the pyruvate dehydrogenase component reaction mapped with mutated and prosthetic group modified lipoyl domains.
The Journal of biological chemistry 2000;275(18):13645-53.
1998: D Yang; Xiaoming Gong; A Yakhnin; Thomas E Roche
Requirements for the adaptor protein role of dihydrolipoyl acetyltransferase in the up-regulated function of the pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
The Journal of biological chemistry 1998;273(23):14130-7.
1997: D Yang; J Song; T Wagenknecht; Thomas E Roche
Assembly and full functionality of recombinantly expressed dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex.
The Journal of biological chemistry 1997;272(10):6361-9.
1996: G Chen; L Wang; S Liu; C Chuang; Thomas E Roche
Activated function of the pyruvate dehydrogenase phosphatase through Ca2+-facilitated binding to the inner lipoyl domain of the dihydrolipoyl acetyltransferase.
The Journal of biological chemistry 1996;271(45):28064-70.
1996: S Ravindran; G A Radke; J R Guest; Thomas E Roche
Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity.
The Journal of biological chemistry 1996;271(2):653-62.
1995: S Liu; J C Baker; Philip C Andrews; Thomas E Roche
Recombinant expression and evaluation of the lipoyl domains of the dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex.
Archives of biochemistry and biophysics 1995;316(2):926-40.
1995: S Liu; J C Baker; Thomas E Roche
Binding of the pyruvate dehydrogenase kinase to recombinant constructs containing the inner lipoyl domain of the dihydrolipoyl acetyltransferase component.
The Journal of biological chemistry 1995;270(2):793-800.
1993: K Ono; G A Radke; Thomas E Roche; M Rahmatullah
Partial activation of the pyruvate dehydrogenase kinase by the lipoyl domain region of E2 and interchange of the kinase between lipoyl domain regions.
The Journal of biological chemistry 1993;268(35):26135-43.
1993: Thomas E Roche; S L Powers-Greenwood; W F Shi; W B Zhang; S Z Ren; E D Roche; D J Cox; C M Sorensen
Sizing of bovine heart and kidney pyruvate dehydrogenase complex and dihydrolipoyl transacetylase core by quasielastic light scattering.
Biochemistry 1993;32(21):5629-37.
1993: G A Radke; K Ono; S Ravindran; Thomas E Roche
Critical role of a lipoyl cofactor of the dihydrolipoyl acetyltransferase in the binding and enhanced function of the pyruvate dehydrogenase kinase.
Biochemical and biophysical research communications 1993;190(3):982-91.
1992: L Li; G A Radke; K Ono; Thomas E Roche
Additional binding sites for the pyruvate dehydrogenase kinase but not for protein X in the assembled core of the mammalian pyruvate dehydrogenase complex: binding region for the kinase.
Archives of biochemistry and biophysics 1992;296(2):497-504.
1991: Terence Wagenknecht; Robert A Grassucci; G A Radke; Thomas E Roche
Cryoelectron microscopy of mammalian pyruvate dehydrogenase complex.
The Journal of biological chemistry 1991;266(36):24650-6.
1990: M Rahmatullah; G A Radke; Philip C Andrews; Thomas E Roche
Changes in the core of the mammalian-pyruvate dehydrogenase complex upon selective removal of the lipoyl domain from the transacetylase component but not from the protein X component.
The Journal of biological chemistry 1990;265(24):14512-7.
1989: S Gopalakrishnan; M Rahmatullah; G A Radke; S Powers-Greenwood; Thomas E Roche
Role of protein X in the function of the mammalian pyruvate dehydrogenase complex.
Biochemical and biophysical research communications 1989;160(2):715-21.
1989: S L Powers-Greenwood; M Rahmatullah; G A Radke; Thomas E Roche
Separation of protein X from the dihydrolipoyl transacetylase component of the mammalian pyruvate dehydrogenase complex and function of protein X.
The Journal of biological chemistry 1989;264(7):3655-7.
1989: M Rahmatullah; S Gopalakrishnan; Philip C Andrews; C L Chang; G A Radke; Thomas E Roche
Subunit associations in the mammalian pyruvate dehydrogenase complex. Structure and role of protein X and the pyruvate dehydrogenase component binding domain of the dihydrolipoyl transacetylase component.
The Journal of biological chemistry 1989;264(4):2221-7.
1989: M Rahmatullah; S Gopalakrishnan; G A Radke; Thomas E Roche
Domain structures of the dihydrolipoyl transacetylase and the protein X components of mammalian pyruvate dehydrogenase complex. Selective cleavage by protease Arg C.
The Journal of biological chemistry 1989;264(2):1245-51.
1989: Thomas E Roche
A tribute to Lester J. Reed.
Annals of the New York Academy of Sciences 1989;573():xiv-xviii.
1989: Thomas E Roche; M Rahmatullah; S L Powers-Greenwood; G A Radke; S Gopalakrishnan; C L Chang
The lipoyl-containing components of the mammalian pyruvate dehydrogenase complex: structural comparison and subdomain roles.
Annals of the New York Academy of Sciences 1989;573():66-75.
1989: Thomas E Roche; M Rahmatullah; L Li; G A Radke; C L Chang; S L Powers-Greenwood
Lipoyl-containing components of the pyruvate dehydrogenase complex: roles in modulating and anchoring the PDH kinase and the PDH phosphatase.
Annals of the New York Academy of Sciences 1989;573():168-74.
1988: M Rahmatullah; Thomas E Roche
Component requirements for NADH inhibition and spermine stimulation of pyruvate dehydrogenaseb phosphatase activity.
The Journal of biological chemistry 1988;263(17):8106-10.
1987: M Rahmatullah; Thomas E Roche
The catalytic requirements for reduction and acetylation of protein X and the related regulation of various forms of resolved pyruvate dehydrogenase kinase.
The Journal of biological chemistry 1987;262(21):10265-71.
1986: M Rahmatullah; J M Jilka; G A Radke; Thomas E Roche
Properties of the pyruvate dehydrogenase kinase bound to and separated from the dihydrolipoyl transacetylase-protein X subcomplex and evidence for binding of the kinase to protein X.
The Journal of biological chemistry 1986;261(14):6515-23.
1986: J M Jilka; M Rahmatullah; M Kazemi; Thomas E Roche
Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex.
The Journal of biological chemistry 1986;261(4):1858-67.
1985: M Rahmatullah; Thomas E Roche
Modification of bovine kidney pyruvate dehydrogenase kinase activity by CoA esters and their mechanism of action.
The Journal of biological chemistry 1985;260(18):10146-52.
1985: M Rahmatullah; Thomas E Roche; J M Jilka; M Kazemi
Mechanism of activation of bovine kidney pyruvate dehydrogenase a kinase by malonyl-CoA and enzyme-catalyzed decarboxylation of malonyl-CoA.
European journal of biochemistry / FEBS 1985;150(1):181-7.