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Alicja Bielawska

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Majd Alghatrif; Djahida Bedja; Alicja Bielawska; Karen Fox-Talbot; Kathleen L Gabrielson; Marc Halushka; Karen L Miller; Xiaolin Niu; Koenraad Vandegaer; Vabren L Watts; Lili A Barouch
Beneficial cardiac effects of caloric restriction are lost with age in a murine model of obesity.
Agnieszka Maryniak; Maria Miszczak-Knecht; Katarzyna Bieganowska; Alicja Bielawska; Franciszek Walczak; Lukasz Szumowski
Does atrioventricular reentry tachycardia (AVRT) or atrioventricular nodal reentry tachycardia (AVNRT) in children affect their cognitive and emotional development?
Thomas H Beckham; Craig C Beeson; Gyda Beeson; Alicja Bielawska; Jacek Bielawski; Joseph C Cheng; Richard R Drake; Elizabeth E Jones; Clayton S Lewis; Ping Lu; Tucker Marrison; James S Norris; Besim Ogretmen; Venkat K Ramshesh; Zdzislaw Szulc; Xiang Liu
LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.

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All Publications

2013: Majd Alghatrif; Djahida Bedja; Alicja Bielawska; Karen Fox-Talbot; Kathleen L Gabrielson; Marc Halushka; Karen L Miller; Xiaolin Niu; Koenraad Vandegaer; Vabren L Watts; Lili A Barouch
Beneficial cardiac effects of caloric restriction are lost with age in a murine model of obesity.
Journal of cardiovascular translational research 2013;6(3):436-45.
2013: Agnieszka Maryniak; Maria Miszczak-Knecht; Katarzyna Bieganowska; Alicja Bielawska; Franciszek Walczak; Lukasz Szumowski
Does atrioventricular reentry tachycardia (AVRT) or atrioventricular nodal reentry tachycardia (AVNRT) in children affect their cognitive and emotional development?
Pediatric cardiology 2013;34(4):893-7.
2013: Thomas H Beckham; Craig C Beeson; Gyda Beeson; Alicja Bielawska; Jacek Bielawski; Joseph C Cheng; Richard R Drake; Elizabeth E Jones; Clayton S Lewis; Ping Lu; Tucker Marrison; James S Norris; Besim Ogretmen; Venkat K Ramshesh; Zdzislaw Szulc; Xiang Liu
LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.
The Journal of pharmacology and experimental therapeutics 2013;344(1):167-78.
2012: Meenu N Perera; Yuri K Peterson; Zdzislaw M Szulc; Alicja Bielawska; Robert Bittman; Shang H Lin; Marco Colombini
Bax and Bcl-xL exert their regulation on different sites of the ceramide channel.
The Biochemical journal 2012;445(1):81-91.
2012: Meenu N Perera; Leah J Siskind; Zdzislaw M Szulc; Vidyaramanan Ganesan; Alicja Bielawska; Jacek Bielawski; Robert Bittman; Marco Colombini
Ceramide channels: influence of molecular structure on channel formation in membranes.
Biochimica et biophysica acta 2012;1818(5):1291-301.
2012: Jean-Philip Truman; Gabriel Virella; Mohammed M Al Gadban; Alicja Bielawska; Yusuf A Hannun; Russell W Jenkins; Maria F Lopes-Virella; Nalini Mayroo; Kent J Smith; Samar M Hammad
Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release.
Immunology 2012;136(1):30-45.
2011: Cecilia M Devlin; Walter Hubbard; Mircea Ivan; Tim Lahm; Lina M Obeid; Mary Van Demark; Kevin C Wang; Xue Wu; Alicja Bielawska; Irina Petrache
Dihydroceramide-based response to hypoxia.
The Journal of biological chemistry 2011;286(44):38069-78.
2011: Abo Bakr Abdel Shakor; Hiroyuki Takeya; Makoto Taniguchi; Hisanori Umehara; Ken Watanabe; Satoshi Asano; Alicja Bielawska; Jacek Bielawski; Mayumi Hashimoto; Akira Hayashi; Yasuyuki Igarashi; Kazuyuki Kitatani; Toshihide Kobayashi; Kenichi Nomura; Toshiro Okazaki
Sphingomyelin synthase 1-generated sphingomyelin plays an important role in transferrin trafficking and cell proliferation.
The Journal of biological chemistry 2011;286(41):36053-62.
2011: Duska Separovic; Aiping Bai; Gaurav Bhatti; Jacek Bielawski; Paul Breen; Eric Van Buren; Nicholas Joseph; Jason S Pierce; Ziad H Saad; Alicja Bielawska
Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization.
Biochemical and biophysical research communications 2011;409(3):372-7.
2011: Xiaolin Hu; Dafeng Yang; Mary Zimmerman; Feiyan Liu; Jine Yang; Swati Kannan; Andreas Burchert; Zdzislaw Szulc; Alicja Bielawska; Keiko Ozato; Kapil N Bhalla; Kebin Liu
IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia.
Cancer research 2011;71(8):2882-91.
2011: Qi Hou; Junfei Jin; Hui Zhou; Sergei Novgorodov; Alicja Bielawska; Zdzislaw M Szulc; Yusuf A Hannun; Lina M Obeid; Yi-Te Hsu
Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.
Journal of lipid research 2011;52(2):278-88.
2011: Duska Separovic; Ziad H Saad; Ethan A Edwin; Jacek Bielawski; Jason S Pierce; Eric Van Buren; Alicja Bielawska
C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing.
Journal of lipids 2011;2011():713867.
2010: Szczepan Józefowski; Maciej Czerkies; Anna Łukasik; Alicja Bielawska; Jacek Bielawski; Katarzyna Kwiatkowska; Andrzej Sobota
Ceramide and ceramide 1-phosphate are negative regulators of TNF-α production induced by lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(11):6960-73.
2010: Zdzislaw Szulc; Aiping Bai; Jacek Bielawski; Nalini Mayroo; Doreen E Miller; Hanna Gracz; Yusuf A Hannun; Alicja Bielawska
Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells.
Bioorganic & medicinal chemistry 2010;18(21):7565-79.
2010: Samar M Hammad; Jason S Pierce; Farzan Soodavar; Kent J Smith; Mohammed M Al Gadban; Barbara Rembiesa; Richard L Klein; Yusuf A Hannun; Jacek Bielawski; Alicja Bielawska
Blood sphingolipidomics in healthy humans: impact of sample collection methodology.
Journal of lipid research 2010;51(10):3074-87.
2010: Jacek Bielawski; Jason S Pierce; Justin Snider; Barbara Rembiesa; Zdzislaw Szulc; Alicja Bielawska
Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).
Advances in experimental medicine and biology 2010;688():46-59.
2009: Xiang Liu; Joseph C Cheng; Lorianne S Turner; saeed elojeimy; Thomas H Beckham; Alicja Bielawska; Thomas E Keane; Yusuf A Hannun; james norris
Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.
Expert opinion on therapeutic targets 2009;13(12):1449-58.
2009: Junfei Jin; Thomas D Mullen; Qi Hou; Jacek Bielawski; Alicja Bielawska; Xiaoming Zhang; Lina M Obeid; Yusuf A Hannun; Yi-Te Hsu
AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.
Journal of lipid research 2009;50(12):2389-97.
2009: Dayanjan S Wijesinghe; Preeti Subramanian; Nadia F Lamour; Luciana B Gentile; Maria H Granado; Alicja Bielawska; Zdzislaw Szulc; Antonio Gomez-Munoz; Charles E Chalfant
Chain length specificity for activation of cPLA2alpha by C1P: use of the dodecane delivery system to determine lipid-specific effects.
Journal of lipid research 2009;50(10):1986-95.
2009: Aiping Bai; Zdzislaw Szulc; Jacek Bielawski; Nalini Mayroo; Xiang Liu; James S. Norris; Yusuf A Hannun; Alicja Bielawska
Synthesis and bioevaluation of omega-N-amino analogs of B13.
Bioorganic & medicinal chemistry 2009;17(5):1840-8.
2009: Ayman E M Mahdy; Joseph C Cheng; Jun Li; saeed elojeimy; William D Meacham; Lorianne S Turner; Aiping Bai; Christopher R Gault; Alex S McPherson; Nicole Garcia; Thomas H Beckham; Antonio Saad; Alicja Bielawska; Jacek Bielawski; Yusuf A Hannun; Thomas E Keane; Mohhammed I Taha; Hisham M Hammouda; james norris; Xiang Liu
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(3):430-8.
2009: Ziad Nahas; Yan Jiang; Youssef H Zeidan; Alicja Bielawska; Zdzislaw Szulc; Lindsay Devane; Peter W Kalivas; Yusuf A Hannun
Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats.
Behavioural brain research 2009;197(1):41-4.
2009: Jacek Bielawski; Jason S Pierce; Justin Snider; Barbara Rembiesa; Zdzislaw Szulc; Alicja Bielawska
Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2009;579():443-67.
2008: Junfei Jin; Qi Hou; Thomas D Mullen; Youssef H Zeidan; Jacek Bielawski; Jacqueline M Kraveka; Alicja Bielawska; Lina M Obeid; Yusuf A Hannun; Yi-Te Hsu
Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells.
The Journal of biological chemistry 2008;283(39):26509-17.
2008: Shoghag Panjarian; Lina Kozhaya; Sawsan Arayssi; Maisaa Yehia; Jacek Bielawski; Alicja Bielawska; Julnar Usta; Yusuf A Hannun; Lina M Obeid; Ghassan Dbaibo
De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.
Prostaglandins & other lipid mediators 2008;86(1-4):41-8.
2008: Agnieszka Maryniak; Alicja Bielawska; Franciszek Walczak; Łukasz Szumowski; Katarzyna Bieganowska; Joanna Rekawek; Monika Paszke; Elzbieta Szymaniak; Maria Knecht
Long-term cognitive outcome in teenage survivors of arrhythmic cardiac arrest.
Resuscitation 2008;77(1):46-50.
2008: David H Holman; Lorianne S Turner; Ahmed El-Zawahry; saeed elojeimy; Xiang Liu; Jacek Bielawski; Zdzislaw Szulc; Kristi Norris; Youssef H Zeidan; Yusuf A Hannun; Alicja Bielawska; james norris
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells.
Cancer chemotherapy and pharmacology 2008;61(2):231-42.
2008: Felix Dahm; Alicja Bielawska; Antonio Nocito; Panco Georgiev; Zdzislaw Szulc; Jacek Bielawski; Wolfram Jochum; Daniel Dindo; Yusuf A Hannun; Pierre-Alain Clavien
Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice.
British journal of cancer 2008;98(1):98-105.
2008: Alicja Bielawska; Jacek Bielawski; Zdzislaw Szulc; Nalini Mayroo; Xiang Liu; Aiping Bai; saeed elojeimy; Barbara Rembiesa; Jason Pierce; james norris; Yusuf A Hannun
Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.
Bioorganic & medicinal chemistry 2008;16(2):1032-45.
2008: Zdzislaw Szulc; Nalini Mayroo; Aiping Bai; Jacek Bielawski; Xiang Liu; james norris; Yusuf A Hannun; Alicja Bielawska
Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.
Bioorganic & medicinal chemistry 2008;16(2):1015-31.
2008: Xiang Liu; saeed elojeimy; Lorianne S Turner; Ayman E M Mahdy; Youssef H Zeidan; Alicja Bielawska; Jacek Bielawski; Jian-Yun Dong; Ahmed El-Zawahry; Gui-wen Guo; Yusuf A Hannun; David H Holman; Semyon Rubinchik; Zdzislaw Szulc; Thomas E Keane; Mahvash Tavassoli; james norris
Acid ceramidase inhibition: a novel target for cancer therapy.
Frontiers in bioscience : a journal and virtual library 2008;13():2293-8.
2007: Valérie Gouazé-Andersson; Jing Y Yu; Adam J Kreitenberg; Alicja Bielawska; Armando E Giuliano; Myles C Cabot
Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells.
Biochimica et biophysica acta 2007;1771(12):1407-17.
2007: Kiyomi Mizugishi; Cuiling Li; Ana Olivera; Jacek Bielawski; Alicja Bielawska; Chu-Xia Deng; Richard L Proia
Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice.
The Journal of clinical investigation 2007;117(10):2993-3006.
2007: Ryan Rhome; Travis McQuiston; Talar B Kechichian; Alicja Bielawska; Mirko Hennig; Monica Drago; Giulia Morace; Chiara Luberto; Maurizio Del Poeta
Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens.
Eukaryotic cell 2007;6(10):1715-26.
2007: Antonio F Saad; William D Meacham; Aiping Bai; Viviana Anelli; saeed elojeimy; Ayman E M Mahdy; Lorianne S Turner; Joe Cheng; Alicja Bielawska; Jacek Bielawski; Thomas E Keane; Lina M Obeid; Yusuf A Hannun; james norris; Xiang Liu
The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy.
Cancer biology & therapy 2007;6(9):1455-60.
2007: Jin Yu; Sergei Novgorodov; Daria Chudakova; Hong Zhu; Alicja Bielawska; Jacek Bielawski; Lina M Obeid; Mark S Kindy; Tatyana I Gudz
JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction.
The Journal of biological chemistry 2007;282(35):25940-9.
2007: saeed elojeimy; Xiang Liu; John C McKillop; Ahmed El-Zawahry; David H Holman; Jonathan Y Cheng; William D Meacham; Ayman E M Mahdy; Antonio F Saad; Lorianne S Turner; Joseph Cheng; Terrence A Day; Jian-Yun Dong; Alicja Bielawska; Yusuf A Hannun; james norris
Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(7):1259-63.
2007: Jacqueline M Kraveka; Li Li; Zdzislaw Szulc; Jacek Bielawski; Besim Ogretmen; Yusuf A Hannun; Lina M Obeid; Alicja Bielawska
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.
The Journal of biological chemistry 2007;282(23):16718-28.
2007: Marek Korzeniowski; Abo Bakr Eltayeb Abdel Shakor; Agnieszka Makowska; Anna Drzewiecka; Alicja Bielawska; Katarzyna Kwiatkowska; Andrzej Sobota
Fc gamma RII activation induces cell surface ceramide production which participates in the assembly of the receptor signaling complex.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(5):347-56.
2006: Felix Dahm; Antonio Nocito; Alicja Bielawska; Karl S Lang; Panco Georgiev; L M Asmis; Jacek Bielawski; J Madon; Yusuf A Hannun; Pierre-Alain Clavien
Distribution and dynamic changes of sphingolipids in blood in response to platelet activation.
Journal of thrombosis and haemostasis : JTH 2006;4(12):2704-9.
2006: james norris; Alicja Bielawska; Terrence A. Day; A El-Zawahri; saeed elojeimy; Yusuf A Hannun; David H Holman; Marc L Hyer; C Landon; S Lowe; Jian-Yun Dong; John C McKillop; Kristi Norris; Lina M Obeid; Semyon Rubinchik; Mahvash Tavassoli; Stephen Tomlinson; Christina Voelkel Johnson; Xiang Liu
Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report.
Cancer gene therapy 2006;13(12):1045-51.
2006: Xiang Liu; Youssef H Zeidan; saeed elojeimy; David H Holman; Ahmed El-Zawahry; Gui-wen Guo; Alicja Bielawska; Jacek Bielawski; Zdzislaw Szulc; Semyon Rubinchik; Jian-Yun Dong; Thomas E Keane; Mahvash Tavassoli; Yusuf A Hannun; james norris
Involvement of sphingolipids in apoptin-induced cell killing.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(5):627-36.
2006: Zdzislaw Szulc; Jacek Bielawski; Hanna Gracz; Marietta Gustilo; Nalini Mayroo; Yusuf A Hannun; Lina M Obeid; Alicja Bielawska
Tailoring structure-function and targeting properties of ceramides by site-specific cationization.
Bioorganic & medicinal chemistry 2006;14(21):7083-104.
2006: Xiang Liu; saeed elojeimy; Ahmed El-Zawahry; David H Holman; Alicja Bielawska; Jacek Bielawski; Semyon Rubinchik; Gui-wen Guo; Jian-Yun Dong; Thomas E Keane; Yusuf A Hannun; Mahvash Tavassoli; james norris
Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(5):637-46.
2006: Jacek Bielawski; Zdzislaw Szulc; Yusuf A Hannun; Alicja Bielawska
Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.
Methods (San Diego, Calif.) 2006;39(2):82-91.
2006: Daniel Dindo; Felix Dahm; Zdzislaw Szulc; Alicja Bielawska; Lina M Obeid; Yusuf A Hannun; Rolf Graf; Pierre-Alain Clavien
Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells.
Molecular cancer therapeutics 2006;5(6):1520-9.
2006: Can E Senkal; Suriyan Ponnusamy; Michael J Rossi; Kamala Sundararaj; Zdzislaw Szulc; Jacek Bielawski; Alicja Bielawska; Mario Meyer; Bengu Cobanoglu; Serap Koybasi; Debajyoti Sinha; Terrence A. Day; Lina M Obeid; Yusuf A Hannun; Besim Ogretmen
Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1188-99.
2006: Mari Kono; Jennifer L Dreier; Jessica M Ellis; Maria Allende; Danielle N Kalkofen; Kathleen M Sanders; Jacek Bielawski; Alicja Bielawska; Yusuf A Hannun; Richard L Proia
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.
The Journal of biological chemistry 2006;281(11):7324-31.
2006: Angela Schulz; Talal Mousallem; Maya Venkataramani; Dixie-Ann Persaud-Sawin; Adam Zucker; Chiara Luberto; Alicja Bielawska; Jacek Bielawski; Joost C M Holthuis; S Michal Jazwinski; Lina Kozhaya; Ghassan Dbaibo; Rose-Mary N Boustany
The CLN9 protein, a regulator of dihydroceramide synthase.
The Journal of biological chemistry 2006;281(5):2784-94.
2006: Iyad Sultan; Can E Senkal; Suriyan Ponnusamy; Jacek Bielawski; Zdzislaw Szulc; Alicja Bielawska; Yusuf A Hannun; Besim Ogretmen
Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.
The Biochemical journal 2006;393(Pt 2):513-21.
2006: Shizhong Bu; Masayoshi Yamanaka; Huiping Pei; Alicja Bielawska; Jacek Bielawski; Yusuf A Hannun; Lina M Obeid; Maria Trojanowska
Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(1):184-6.
2005: Dayanjan S Wijesinghe; Autumn Massiello; Preeti Subramanian; Zdzislaw Szulc; Alicja Bielawska; Charles E Chalfant
Substrate specificity of human ceramide kinase.
Journal of lipid research 2005;46(12):2706-16.
2005: Preeti Subramanian; Robert V Stahelin; Zdzislaw Szulc; Alicja Bielawska; Wonhwa Cho; Charles E Chalfant
Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine.
The Journal of biological chemistry 2005;280(18):17601-7.
2005: Sergei Novgorodov; Zdzislaw Szulc; Chiara Luberto; Jeffrey Jones; Jacek Bielawski; Alicja Bielawska; Yusuf A Hannun; Lina M Obeid
Positively charged ceramide is a potent inducer of mitochondrial permeabilization.
The Journal of biological chemistry 2005;280(16):16096-105.
2005: Michael J Rossi; Kamala Sundararaj; Serap Koybasi; Monique S Phillips; Zdzislaw Szulc; Alicja Bielawska; Terrence A. Day; Lina M Obeid; Yusuf A Hannun; Besim Ogretmen
Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2005;132(1):55-62.
2004: Masayoshi Yamanaka; Daniel Shegogue; Huiping Pei; Shizhong Bu; Alicja Bielawska; Jacek Bielawski; Benjamin J Pettus; Yusuf A Hannun; Lina M Obeid; Maria Trojanowska
Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.
The Journal of biological chemistry 2004;279(52):53994-4001.
2004: Nathan L Alderson; Barbara M Rembiesa; Michael D Walla; Alicja Bielawska; Jacek Bielawski; Hiroko Hama
The human FA2H gene encodes a fatty acid 2-hydroxylase.
The Journal of biological chemistry 2004;279(47):48562-8.
2004: Nour Abboushi; Aimee El-Hed; Wissal El-Assaad; Lina Kozhaya; Marwan E El Sabban; Ali Bazarbachi; Rami Badreddine; Alicja Bielawska; Julnar Usta; Ghassan Dbaibo
Ceramide inhibits IL-2 production by preventing protein kinase C-dependent NF-kappaB activation: possible role in protein kinase Ctheta regulation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3193-200.
2004: Benjamin J Pettus; Alicja Bielawska; Preeti Subramanian; Dayanjan S Wijesinghe; Michael Maceyka; Christina C Leslie; John H Evans; Jessica Freiberg; Patrick Roddy; Yusuf A Hannun; Charles E Chalfant
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2.
The Journal of biological chemistry 2004;279(12):11320-6.
2004: Leigh Samsel; Grazyna Zaidel; Honesty M Drumgoole; Danijela Jelovac; Cinthia Drachenberg; Juong G Rhee; Angela Brodie; Alicja Bielawska; Mary J Miriam Smyth
The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts.
The Prostate 2004;58(4):382-93.
2004: Charles E Chalfant; Zdzislaw Szulc; Patrick Roddy; Alicja Bielawska; Yusuf A Hannun
The structural requirements for ceramide activation of serine-threonine protein phosphatases.
Journal of lipid research 2004;45(3):496-506.
2004: Kamala Sundararaj; Rachel E Wood; Suriyan Ponnusamy; Arelis M Salas; Zdzislaw Szulc; Alicja Bielawska; Lina M Obeid; Yusuf A Hannun; Besim Ogretmen
Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase.
The Journal of biological chemistry 2004;279(7):6152-62.
2004: Benjamin J Pettus; Bart-Jan Kroesen; Zdzislaw Szulc; Alicja Bielawska; Jacek Bielawski; Yusuf A Hannun; Mark Busman
Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(5):577-83.
2003: Benjamin J Pettus; Alicja Bielawska; Sarah Spiegel; Patrick Roddy; Yusuf A Hannun; Charles E Chalfant
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.
The Journal of biological chemistry 2003;278(40):38206-13.
2003: Cungui Mao; Ruijuan Xu; Zdzislaw Szulc; Jacek Bielawski; Kevin P Becker; Alicja Bielawska; Sehamuddin Galadari; Wei Hu; Lina M Obeid
Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides.
The Journal of biological chemistry 2003;278(33):31184-91.
2003: Madoka Sato; Margaret Markiewicz; Masoyoshi Yamanaka; Alicja Bielawska; Cungui Mao; Lina M Obeid; Yusuf A Hannun; Maria Trojanowska
Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.
The Journal of biological chemistry 2003;278(11):9276-82.
2003: Benjamin J Pettus; Alicja Bielawska; Bart-Jan Kroesen; Peter D R Moeller; Zdzislaw Szulc; Yusuf A Hannun; Mark Busman
Observation of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 2003;17(11):1203-11.
2002: L Ashley Cowart; Zdzislaw Szulc; Alicja Bielawska; Yusuf A Hannun
Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodies.
Journal of lipid research 2002;43(12):2042-8.
2002: Besim Ogretmen; Benjamin J Pettus; Michael J Rossi; Rachel Wood; Julnar Usta; Zdzislaw Szulc; Alicja Bielawska; Lina M Obeid; Yusuf A Hannun
Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.
The Journal of biological chemistry 2002;277(15):12960-9.
2002: Monika Raisova; Gerit Goltz; Meryem Bektas; Alicja Bielawska; Christian Riebeling; Amir M Hossini; Jürgen Eberle; Yusuf A Hannun; Constantin E Orfanos; Christoph C Geilen
Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.
FEBS letters 2002;516(1-3):47-52.
2002: Samer El Bawab; Julnar Usta; Patrick Roddy; Zdzislaw Szulc; Alicja Bielawska; Yusuf A Hannun
Substrate specificity of rat brain ceramidase.
Journal of lipid research 2002;43(1):141-8.
2001: Alicja Bielawska; David K Perry; Yusuf A Hannun
Determination of ceramides and diglycerides by the diglyceride kinase assay.
Analytical biochemistry 2001;298(2):141-50.
2001: Julnar Usta; Samer El Bawab; Patrick Roddy; Zdzislaw Szulc; A Hannun; Alicja Bielawska
Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase.
Biochemistry 2001;40(32):9657-68.
2001: Cungui Mao; Ruijuan Xu; Zdzislaw Szulc; Alicja Bielawska; Sehamuddin Galadari; Lina M Obeid
Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide.
The Journal of biological chemistry 2001;276(28):26577-88.
2001: Samer El Bawab; Helene Birbes; Patrick Roddy; Zdzislaw Szulc; Alicja Bielawska; Yusuf A Hannun
Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase.
The Journal of biological chemistry 2001;276(20):16758-66.
2001: Markus Selzner; Alicja Bielawska; Michael A Morse; Hannes A Rüdiger; David Sindram; Yusuf A Hannun; Pierre-Alain Clavien
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
Cancer research 2001;61(3):1233-40.
2000: J Y Lee; Alicja Bielawska; Lina M Obeid
Regulation of cyclin-dependent kinase 2 activity by ceramide.
Experimental cell research 2000;261(2):303-11.
2000: Hirofumi Sawai; Yasuo Okamoto; Chiara Luberto; Cungui Mao; Alicja Bielawska; N Domae; Yusuf A Hannun
Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae.
The Journal of biological chemistry 2000;275(50):39793-8.
2000: Cungui Mao; Ruijuan Xu; Alicja Bielawska; Zdzislaw Szulc; Lina M Obeid
Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide.
The Journal of biological chemistry 2000;275(40):31369-78.
2000: Samer El Bawab; Patrick Roddy; Ting Qian; Alicja Bielawska; John J Lemasters; Yusuf A Hannun
Molecular cloning and characterization of a human mitochondrial ceramidase.
The Journal of biological chemistry 2000;275(28):21508-13.
2000: Cungui Mao; R Xu; Alicja Bielawska; Lina M Obeid
Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity.
The Journal of biological chemistry 2000;275(10):6876-84.
2000: Charles E Chalfant; K Kishikawa; Alicja Bielawska; Yusuf A Hannun
Analysis of ceramide-activated protein phosphatases.
Methods in enzymology 2000;312():420-8.
2000: David K Perry; Alicja Bielawska; Yusuf A Hannun
Quantitative determination of ceramide using diglyceride kinase.
Methods in enzymology 2000;312():22-31.
2000: Alicja Bielawska; Zdzislaw Szulc; Yusuf A Hannun
Synthesis of key precursors of radiolabeled sphingolipids.
Methods in enzymology 2000;311():518-35.
2000: Alicja Bielawska; Yusuf A Hannun
Preparation of radiolabeled ceramides and phosphosphingolipids.
Methods in enzymology 2000;311():499-518.
2000: Alicja Bielawska; Y A Hannum; Zdzislaw Szulc
Radiolabeling of the sphingolipid backbone.
Methods in enzymology 2000;311():480-98.
1999: X Z Wang; J R Beebe; L Pwiti; Alicja Bielawska; Mary J Miriam Smyth
Aberrant sphingolipid signaling is involved in the resistance of prostate cancer cell lines to chemotherapy.
Cancer research 1999;59(22):5842-8.
1999: Samer El Bawab; Alicja Bielawska; Yusuf A Hannun
Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain.
The Journal of biological chemistry 1999;274(39):27948-55.
1999: K Kishikawa; Charles E Chalfant; David K Perry; Alicja Bielawska; Yusuf A Hannun
Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses.
The Journal of biological chemistry 1999;274(30):21335-41.
1999: Charles E Chalfant; K Kishikawa; Marc C Mumby; Craig Kamibayashi; Alicja Bielawska; Yusuf A Hannun
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid.
The Journal of biological chemistry 1999;274(29):20313-7.
1997: Alicja Bielawska; JP Shapiro; L Jiang; Hovsep Melkonyan; CA Piot; C L Wolfe; L David Tomei; Yusuf A Hannun; Samuil R Umansky
Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion.
The American journal of pathology 1997;151(5):1257-63.
1997: Julie Saba; F Nara; Alicja Bielawska; S Garrett; Yusuf A Hannun
The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase.
The Journal of biological chemistry 1997;272(42):26087-90.
1997: Thung Lai; Alicja Bielawska; KA Peoples; Yusuf A Hannun; Charles S Greenberg
Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase.
The Journal of biological chemistry 1997;272(26):16295-300.
1996: Mark E Venable; Alicja Bielawska; Lina M Obeid
Ceramide inhibits phospholipase D in a cell-free system.
The Journal of biological chemistry 1996;271(40):24800-5.
1996: Kawamura Akira; Nina Berova; V Dirsch; A Mangoni; K Nakanishi; G Schwartz; Alicja Bielawska; Yusuf A Hannun; I Kitagawa
Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines.
Bioorganic & medicinal chemistry 1996;4(7):1035-43.
1996: Alicja Bielawska; M S Greenberg; D Perry; S Jayadev; James A Shayman; C McKay; Yusuf A Hannun
(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase.
The Journal of biological chemistry 1996;271(21):12646-54.
1995: Mark E Venable; J Y Lee; Mary J Miriam Smyth; Alicja Bielawska; Lina M Obeid
Role of ceramide in cellular senescence.
The Journal of biological chemistry 1995;270(51):30701-8.
1995: JK Westwick; Alicja Bielawska; Ghassan Dbaibo; Yusuf A Hannun; David A Brenner
Ceramide activates the stress-activated protein kinases.
The Journal of biological chemistry 1995;270(39):22689-92.
1995: C G Tepper; S Jayadev; B Liu; Alicja Bielawska; R Wolff; S Yonehara; Yusuf A Hannun; Michael F Seldin
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8443-7.
1995: Stanley J F Laulederkind; Alicja Bielawska; Rajendra Raghow; Yusuf A Hannun; Leslie R Ballou
Ceramide induces interleukin 6 gene expression in human fibroblasts.
The Journal of experimental medicine 1995;182(2):599-604.
1995: M Pushkareva; R Chao; Alicja Bielawska; Alfred H Merrill; H M Crane; B Lagu; Dennis C Liotta; Yusuf A Hannun
Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine.
Biochemistry 1995;34(6):1885-92.
1995: S Jayadev; B Liu; Alicja Bielawska; J Y Lee; F Nazaire; Lina M Obeid; Yusuf A Hannun
Role for ceramide in cell cycle arrest.
The Journal of biological chemistry 1995;270(5):2047-52.
1994: R A Wolff; Rick T Dobrowsky; Alicja Bielawska; Lina M Obeid; Yusuf A Hannun
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.
The Journal of biological chemistry 1994;269(30):19605-9.
1994: Toshiro Okazaki; Alicja Bielawska; Naochika Domae; R M Bell; Yusuf A Hannun
Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
The Journal of biological chemistry 1994;269(6):4070-7.
1993: Alicja Bielawska; H M Crane; Dennis C Liotta; Lina M Obeid; Yusuf A Hannun
Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.
The Journal of biological chemistry 1993;268(35):26226-32.
1993: Alicja Bielawska; D Menaldiv; Dennis C Liotta; Yusuf A Hannun
Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids.
The Biochemical journal 1993;294 ( Pt 3)():699-703.
1993: J D Fishbein; Rick T Dobrowsky; Alicja Bielawska; S Garrett; Yusuf A Hannun
Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae.
The Journal of biological chemistry 1993;268(13):9255-61.
1992: Alicja Bielawska; C M Linardic; Yusuf A Hannun
Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.
The Journal of biological chemistry 1992;267(26):18493-7.
1992: Alicja Bielawska; C M Linardic; Yusuf A Hannun
Modulation of cell growth and differentiation by ceramide.
FEBS letters 1992;307(2):211-4.
1992: M H Werner; Alicja Bielawska; Yusuf A Hannun
Multiphasic generation of diacylglycerol in thrombin-activated human platelets.
The Biochemical journal 1992;282 ( Pt 3)():815-20.
1992: M H Werner; Alicja Bielawska; Yusuf A Hannun
Quantitative analysis of diacylglycerol second messengers in human platelets: correlation with aggregation and secretion.
Molecular pharmacology 1992;41(2):382-6.
1991: M H Werner; L Senzel; Alicja Bielawska; W Khan; Yusuf A Hannun
Diacylglycerol overcomes aspirin inhibition of platelets: evidence for a necessary role for diacylglycerol accumulation in platelet activation.
Molecular pharmacology 1991;39(4):547-56.
1990: T Okazaki; Alicja Bielawska; R M Bell; Yusuf A Hannun
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
The Journal of biological chemistry 1990;265(26):15823-31.
1989: D C Sane; Alicja Bielawska; Charles S Greenberg; Yusuf A Hannun
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets.
Biochemical and biophysical research communications 1989;165(2):708-14.