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Howard Rockman

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Hao Tang; Kunhong Xiao; Lan Mao; Howard A Rockman; Douglas A Marchuk
Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.
Ki-Seok Kim; Lan Mao; Jonathan D Violin; Barbara Williams; Dennis Abraham; Howard A Rockman
β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.
Chang-Lung Lee; Yifan Li; Yan Ma; Lan Mao; Everett J Moding; Howard A Rockman; Rafaela C Rodrigues; Julie M Sullivan; Iman Washington; Kyle C Cuneo; Shiva Das; Laura B Jeffords; Yongbaek Kim; Christopher D Kontos; David G Kirsch
p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.

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All Publications

2013: Hao Tang; Kunhong Xiao; Lan Mao; Howard A Rockman; Douglas A Marchuk
Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.
Journal of molecular and cellular cardiology 2013;54():101-11.
2012: Ki-Seok Kim; Lan Mao; Jonathan D Violin; Barbara Williams; Dennis Abraham; Howard A Rockman
β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.
American journal of physiology. Heart and circulatory physiology 2012;303(8):H1001-10.
2012: Chang-Lung Lee; Yifan Li; Yan Ma; Lan Mao; Everett J Moding; Howard A Rockman; Rafaela C Rodrigues; Julie M Sullivan; Iman Washington; Kyle C Cuneo; Shiva Das; Laura B Jeffords; Yongbaek Kim; Christopher D Kontos; David G Kirsch
p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.
Science signaling 2012;5(234):ra52.
2012: Michelle E Casad; Joseph P Daniels; Matthew J Wolf; Lin Yu; Howard A Rockman
Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy.
Molecular genetics and genomics : MGG 2012;287(4):351-60.
2011: Michelle E Casad; Brian Dong; Stephan Frangakis; Il-Man Kim; Na Lin; Dennis Abraham; Matthew J Wolf; Howard A Rockman
Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster.
Genetics 2011;189(3):861-70.
2011: Nabila Noor; Chetan B Patel; Howard A Rockman
Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.
Journal of molecular and cellular cardiology 2011;51(4):534-41.
2011: Sudha K Shenoy; Howard A Rockman
Cardiovascular biology: heart fails without pump partner.
Nature 2011;477(7366):546-7.
2011: Matthew J Wolf; Howard A Rockman
Drosophila, genetic screens, and cardiac function.
Circulation research 2011;109(7):794-806.
2011: Howard A Rockman; Robert J Lefkowitz
Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling.
Circulation research 2011;109(2):202-4.
2011: Na Lin; Nima Badie; Lin Yu; Dennis Abraham; Heping Cheng; Nenad Bursac; Howard A Rockman; Matthew J Wolf
A method to measure myocardial calcium handling in adult Drosophila.
Circulation research 2011;108(11):1306-15.
2010: Chetan B Patel; Nabila Noor; Howard A Rockman
Functional selectivity in adrenergic and angiotensin signaling systems.
Molecular pharmacology 2010;78(6):983-92.
2010: Byung-Eun Kim; Michelle L Turski; Yasuhiro Nose; Michelle Casad; Howard A Rockman; Dennis J Thiele
Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.
Cell metabolism 2010;11(5):353-63.
2010: Supachoke Mangmool; arun shukla; Howard A Rockman
beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation.
The Journal of cell biology 2010;189(3):573-87.
2010: Il-Man Kim; Matthew J Wolf; Howard A Rockman
Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.
Circulation research 2010;106(7):1233-43.
2010: Elizabeth Bucholz; Ketan B Ghaghada; Yi Qi; Srinivasan Mukundan; Howard A Rockman; G Allan Johnson
Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2010;63(4):979-87.
2010: Kriti Rakesh; ByungSu Yoo; Il-Man Kim; Natasha Salazar; Ki-Seok Kim; Howard A Rockman
beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress.
Science signaling 2010;3(125):ra46.
2009: ByungSu Yoo; Anthony Lemaire; Supachoke Mangmool; Matthew J Wolf; Antonio Curcio; Lan Mao; Howard A Rockman
Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2009;297(4):H1377-86.
2009: Ferrin C Wheeler; Hao Tang; Odessa A Marks; Tracy N Hadnott; Pei-Lun Chu; Lan Mao; Howard A Rockman; Douglas A Marchuk
Tnni3k modifies disease progression in murine models of cardiomyopathy.
PLoS genetics 2009;5(9):e1000647.
2009: Douglas G Tilley; Il-Man Kim; Priyesh A Patel; Jonathan D Violin; Howard A Rockman
beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling.
The Journal of biological chemistry 2009;284(30):20375-86.
2009: Kumar Pandya; Kristine Porter; Howard A Rockman; Oliver Smithies
Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain.
European journal of heart failure 2009;11(7):648-52.
2009: Liliana Fernandez; Douglas A Marchuk; Jennifer L Moran; David Beier; Howard A Rockman
An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15.
Mammalian genome : official journal of the International Mammalian Genome Society 2009;20(5):296-304.
2009: Brian Lima; Gregory K W Lam; Liang Xie; Diana L Diesen; Nestor Villamizar; Jeffrey Nienaber; Emily Messina; Dawn Bowles; Christopher D Kontos; Joshua M Hare; Jonathan S Stamler; Howard A Rockman
Endogenous S-nitrosothiols protect against myocardial injury.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6297-302.
2009: Priyesh A Patel; Douglas G Tilley; Howard A Rockman
Physiologic and cardiac roles of beta-arrestins.
Journal of molecular and cellular cardiology 2009;46(3):300-8.
2008: Priyesh A Patel; Douglas G Tilley; Howard A Rockman
Beta-arrestin-mediated signaling in the heart.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(11):1725-9.
2008: Il-Man Kim; Douglas G Tilley; J Chen; Natasha C Salazar; Erin J Whalen; Jonathan D Violin; Howard A Rockman
Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14555-60.
2008: Kumar Pandya; John Cowhig; Joe Brackhan; Hyung-Suk Kim; John R Hagaman; Mauricio Rojas; Charles Carter; Lan Mao; Howard A Rockman; Nobuyo Maeda; Oliver Smithies
Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):13063-8.
2008: Liza Barki-Harrington; Howard A Rockman
Beta-arrestins: multifunctional cellular mediators.
Physiology (Bethesda, Md.) 2008;23():17-22.
2008: Giovanni Esposito; Cinzia Perrino; Tohru Ozaki; Hideyuki Takaoka; Nicole Defer; Mario Petretta; Maria Carmen De Angelis; Lan Mao; Jacques Hanoune; Howard A Rockman; Massimo Chiariello
Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8.
Basic research in cardiology 2008;103(1):22-30.
2007: Bennett B Chin; Scott D Metzler; Anthony Lemaire; Antonio Curcio; Sreekanth Vemulapalli; Kim L Greer; Neil Petry; Timothy G Turkington; R Edward Coleman; Howard A Rockman; Ronald J Jaszczak
Left ventricular functional assessment in mice: feasibility of high spatial and temporal resolution ECG-gated blood pool SPECT.
Radiology 2007;245(2):440-8.
2007: Harmony R Salzler; Robert Griffiths; Phillip Ruiz; L Chi; C Frey; Douglas A Marchuk; Howard A Rockman; Thu H Le
Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus.
Kidney international 2007;72(10):1226-32.
2007: Takahisa Noma; Anthony Lemaire; Sathyamangla V Naga Prasad; Liza Barki-Harrington; Douglas G Tilley; Juhsien Chen; Philippe Le Corvoisier; Jonathan D Violin; Huijun Wei; Robert J Lefkowitz; Howard A Rockman
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.
The Journal of clinical investigation 2007;117(9):2445-58.
2007: Cinzia Perrino; Howard A Rockman
Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure.
Current opinion in cardiology 2007;22(5):443-9.
2007: Cristian T Badea; Laurence W Hedlund; Julie F Boslego Mackel; Lan Mao; Howard A Rockman; G Allan Johnson
Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice.
Molecular imaging 2007;6(4):261-8.
2007: Erin J Whalen; Matthew W Foster; Akio Matsumoto; Kentaro Ozawa; Jonathan D Violin; Loretta G Que; Christopher D Nelson; Moran Benhar; Janelle R Keys; Howard A Rockman; Walter J Koch; Yehia A Daaka; Robert J Lefkowitz; Jonathan S Stamler
Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.
Cell 2007;129(3):511-22.
2007: Natasha C Salazar; Juhsien Chen; Howard A Rockman
Cardiac GPCRs: GPCR signaling in healthy and failing hearts.
Biochimica et biophysica acta 2007;1768(4):1006-18.
2006: Keshava Rajagopal; Erin J Whalen; Jonathan D Violin; Jonathan A Stiber; Paul B Rosenberg; Richard T Premont; Thomas M Coffman; Howard A Rockman; Robert J Lefkowitz
Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16284-9.
2006: Mark P Donahue; Douglas A Marchuk; Howard A Rockman
Redefining heart failure: the utility of genomics.
Journal of the American College of Cardiology 2006;48(7):1289-98.
2006: Antonio Curcio; Takahisa Noma; Sathyamangla V Naga Prasad; Matthew J Wolf; Anthony Lemaire; Cinzia Perrino; Lan Mao; Howard A Rockman
Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling.
American journal of physiology. Heart and circulatory physiology 2006;291(4):H1754-60.
2006: Susan B Gurley; Alicia Allred; Thu H Le; Robert Griffiths; Lan Mao; Nisha Philip; Timothy A J Haystead; Mary Donoghue; Roger E Breitbart; Susan L Acton; Howard A Rockman; Thomas M Coffman
Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.
The Journal of clinical investigation 2006;116(8):2218-25.
2006: Cinzia Perrino; Howard A Rockman; Massimo Chiariello
Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure.
Vascular pharmacology 2006;45(2):77-85.
2006: Cinzia Perrino; Sathyamangla V Naga Prasad; Lan Mao; Takahisa Noma; Zhen Yan; Hyung-Suk Kim; Oliver Smithies; Howard A Rockman
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.
The Journal of clinical investigation 2006;116(6):1547-60.
2006: Hideo Tachibana; Cinzia Perrino; Hideyuki Takaoka; Roger J Davis; Sathyamangla V Naga Prasad; Howard A Rockman
JNK1 is required to preserve cardiac function in the early response to pressure overload.
Biochemical and biophysical research communications 2006;343(4):1060-6.
2006: Douglas G Tilley; Howard A Rockman
Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment.
Expert review of cardiovascular therapy 2006;4(3):417-32.
2006: Volovyk Zoya; Matthew J Wolf; Sathyamangla V Naga Prasad; Howard A Rockman
Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover.
The Journal of biological chemistry 2006;281(14):9773-80.
2006: Matthew J Wolf; Hubert Amrein; Joseph A Izatt; Michael A Choma; Mary C Reedy; Howard A Rockman
Drosophila as a model for the identification of genes causing adult human heart disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1394-9.
2006: Cristian T Badea; Elizabeth Bucholz; Laurence W Hedlund; Howard A Rockman; G Allan Johnson
Imaging methods for morphological and functional phenotyping of the rodent heart.
Toxicologic pathology 2006;34(1):111-7.
2005: Keshava Rajagopal; Robert J Lefkowitz; Howard A Rockman
When 7 transmembrane receptors are not G protein-coupled receptors.
The Journal of clinical investigation 2005;115(11):2971-4.
2005: Cinzia Perrino; Giovanni Esposito; Howard A Rockman
Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.
Panminerva medica 2005;47(3):143-55.
2005: Helene Francois; Krairerk Athirakul; David Howell; Rajesh Dash; Lan Mao; Hyung-Suk Kim; Howard A Rockman; garret fitzgerald; Beverly H Koller; Thomas M Coffman
Prostacyclin protects against elevated blood pressure and cardiac fibrosis.
Cell metabolism 2005;2(3):201-7.
2005: Zhiqiang Chen; Matthew W Foster; Jian Zhang; Lan Mao; Howard A Rockman; Toshihiro Kawamoto; Kyoko Kitagawa; Keiichi I Nakayama; Douglas T Hess; Jonathan S Stamler
An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12159-64.
2005: Sathyamangla V Naga Prasad; Arundathi Jayatilleke; Aasakiran Madamanchi; Howard A Rockman
Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.
Nature cell biology 2005;7(8):785-96.
2005: Cinzia Perrino; Sathyamangla V Naga Prasad; Mrinali Patel; Matthew J Wolf; Howard A Rockman
Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression.
Journal of the American College of Cardiology 2005;45(11):1862-70.
2005: Ferrin C Wheeler; Liliana Fernandez; Kerri M Carlson; Matthew J Wolf; Howard A Rockman; Douglas A Marchuk
QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival.
Mammalian genome : official journal of the International Mammalian Genome Society 2005;16(6):414-23.
2005: Cinzia Perrino; Sathyamangla V Naga Prasad; Jacob N Schroder; Jonathan A Hata; Carmelo A Milano; Howard A Rockman
Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex.
Circulation 2005;111(20):2579-87.
2005: Rashid Nassar; Nadia Anderson; Lan Mao; Howard A Rockman; Annette E Oakeley; James R Frye; J René Herlong; Stephen P Sanders; Page A W Anderson
cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform.
American journal of physiology. Heart and circulatory physiology 2005;288(3):H1147-56.
2005: Hideo Tachibana; Sathyamangla V Naga Prasad; Robert J Lefkowitz; Walter J Koch; Howard A Rockman
Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.
Circulation 2005;111(5):591-7.
2005: Matthew J Wolf; Hideo Tachibana; Howard A Rockman
Methods for the detection of altered beta-adrenergic receptor signaling pathways in hypertrophied hearts.
Methods in molecular medicine 2005;112():353-62.
2004: Liza Barki-Harrington; Cinzia Perrino; Howard A Rockman
Network integration of the adrenergic system in cardiac hypertrophy.
Cardiovascular research 2004;63(3):391-402.
2004: Kathleen M Caron; Leighton R James; Hyung-Suk Kim; Josh Knowles; Rick Uhlir; Lan Mao; John R Hagaman; Wayne E Cascio; Howard A Rockman; Oliver Smithies
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3106-11.
2004: Helene Francois; Krairerk Athirakul; Lan Mao; Howard A Rockman; Thomas M Coffman
Role for thromboxane receptors in angiotensin-II-induced hypertension.
Hypertension 2004;43(2):364-9.
2003: Philippe Le Corvoisier; Hyun-Young Park; Kerri M Carlson; Douglas A Marchuk; Howard A Rockman
Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy.
Human molecular genetics 2003;12(23):3097-107.
2003: Janelle R Keys; Emily A Greene; Chris J Cooper; Sathyamangla V Naga Prasad; Howard A Rockman; Walter J Koch
Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1.
American journal of physiology. Heart and circulatory physiology 2003;285(5):H2201-11.
2003: Burns C Blaxall; Rainer Spang; Howard A Rockman; Walter J Koch
Differential myocardial gene expression in the development and rescue of murine heart failure.
Physiological genomics 2003;15(2):105-14.
2003: Jeffrey J Nienaber; Hideo Tachibana; Sathyamangla V Naga Prasad; Giovanni Esposito; Dianqing Wu; Lan Mao; Howard A Rockman
Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure.
The Journal of clinical investigation 2003;112(7):1067-79.
2003: Liza Barki-Harrington; Louis M Luttrell; Howard A Rockman
Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo.
Circulation 2003;108(13):1611-8.
2003: Antonio Rapacciuolo; Shayela Suvarna; Liza Barki-Harrington; Louis M Luttrell; Mei Cong; Robert J Lefkowitz; Howard A Rockman
Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.
The Journal of biological chemistry 2003;278(37):35403-11.
2003: Sathyamangla V Naga Prasad; Cinzia Perrino; Howard A Rockman
Role of phosphoinositide 3-kinase in cardiac function and heart failure.
Trends in cardiovascular medicine 2003;13(5):206-12.
2003: Philippe Le Corvoisier; Hyun-Young Park; Howard A Rockman
Modifier genes and heart failure.
Minerva cardioangiologica 2003;51(2):107-20.
2003: Philippe Le Corvoisier; Hyun-Young Park; Kerri M Carlson; Mark P Donahue; Douglas A Marchuk; Howard A Rockman
Impact of genetic polymorphisms on heart failure prognosis.
Archives des maladies du coeur et des vaisseaux 2003;96(3):197-206.
2003: Josep M Colomer; Lan Mao; Howard A Rockman; Anthony R Means
Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.
Molecular endocrinology (Baltimore, Md.) 2003;17(2):183-92.
2003: Liza Barki-Harrington; Howard A Rockman
Sensing heart stress.
Nature medicine 2003;9(1):19-20.
2002: Giovanni Esposito; Antonio Rapacciuolo; Sathyamangla V Naga Prasad; Howard A Rockman
Cardiac hypertrophy: role of G protein-coupled receptors.
Journal of cardiac failure 2002;8(6 Suppl):S409-14.
2002: David S Feldman; A Musa Zamah; Kristen L Pierce; William E Miller; Francine Kelly; Antonio Rapacciuolo; Howard A Rockman; Walter J Koch; Louis M Luttrell
Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.
The Journal of biological chemistry 2002;277(32):28631-40.
2002: Sathyamangla V Naga Prasad; Stephane Laporte; Dean Chamberlain; Marc G Caron; Larry S Barak; Howard A Rockman
Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.
The Journal of cell biology 2002;158(3):563-75.
2002: Hideyuki Takaoka; Giovanni Esposito; Lan Mao; Hiroyuki Suga; Howard A Rockman
Heart size-independent analysis of myocardial function in murine pressure overload hypertrophy.
American journal of physiology. Heart and circulatory physiology 2002;282(6):H2190-7.
2002: Miwako Suzuki; Kerri M Carlson; Douglas A Marchuk; Howard A Rockman
Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy.
Circulation 2002;105(15):1824-9.
2002: Andrea D Eckhart; Tohru Ozaki; Hendrik T Tevaearai; Howard A Rockman; Walter J Koch
Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure.
Molecular pharmacology 2002;61(4):749-58.
2002: Howard A Rockman; Walter J Koch; Robert J Lefkowitz
Seven-transmembrane-spanning receptors and heart function.
Nature 2002;415(6868):206-12.
2002: Sathyamangla V Naga Prasad; Jeffrey J Nienaber; Howard A Rockman
G-protein-coupled receptor function in heart failure.
Cold Spring Harbor symposia on quantitative biology 2002;67():439-44.
2002: Giovanni Esposito; Antonio Rapacciuolo; Sathyamangla V Naga Prasad; Hideyuki Takaoka; Steven A Thomas; Walter J Koch; Howard A Rockman
Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.
Circulation 2002;105(1):85-92.
2001: Trudy A Kohout; Hideyuki Takaoka; Patricia McDonald; Stephen J Perry; Lan Mao; Robert J Lefkowitz; Howard A Rockman
Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.
Circulation 2001;104(20):2485-91.
2001: Sathyamangla V Naga Prasad; Jeffrey J Nienaber; Howard A Rockman
Beta-adrenergic axis and heart disease.
Trends in genetics : TIG 2001;17(10):S44-9.
2001: Antonio Rapacciuolo; Giovanni Esposito; Sathyamangla V Naga Prasad; Howard A Rockman
G protein-coupled receptor signalling in in vivo cardiac overload.
Acta physiologica Scandinavica 2001;173(1):51-7.
2001: Antonio Rapacciuolo; Giovanni Esposito; Kathleen M Caron; Lan Mao; S A Thomas; Howard A Rockman
Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.
Journal of the American College of Cardiology 2001;38(3):876-82.
2001: guido iaccarino; Janelle R Keys; Antonio Rapacciuolo; KF Shotwell; Robert J Lefkowitz; Howard A Rockman; Walter J Koch
Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
Journal of the American College of Cardiology 2001;38(2):534-40.
2001: Sathyamangla V Naga Prasad; Larry S Barak; Antonio Rapacciuolo; Marc G Caron; Howard A Rockman
Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration.
The Journal of biological chemistry 2001;276(22):18953-9.
2001: V B Harding; L R Jones; Robert J Lefkowitz; Walter J Koch; Howard A Rockman
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5809-14.
2001: Joshua W Knowles; G Esposito; L Mao; John R Hagaman; JE Fox; Oliver Smithies; Howard A Rockman; Nobuyo Maeda
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice.
The Journal of clinical investigation 2001;107(8):975-84.
2001: Giovanni Esposito; Sathyamangla V Naga Prasad; Antonio Rapacciuolo; Lan Mao; Walter J Koch; Howard A Rockman
Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload.
Circulation 2001;103(10):1453-8.
2000: Giovanni Esposito; Luis F Santana; Keith Dilly; J D Cruz; Lan Mao; William Lederer; Howard A Rockman
Cellular and functional defects in a mouse model of heart failure.
American journal of physiology. Heart and circulatory physiology 2000;279(6):H3101-12.
2000: B S Manning; KF Shotwell; Lan Mao; Howard A Rockman; Walter J Koch
Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy.
Circulation 2000;102(22):2751-7.
2000: Sathyamangla V Naga Prasad; Giovanni Esposito; Lan Mao; Walter J Koch; Howard A Rockman
Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy.
The Journal of biological chemistry 2000;275(7):4693-8.
2000: Walter J Koch; Robert J Lefkowitz; Howard A Rockman
Functional consequences of altering myocardial adrenergic receptor signaling.
Annual review of physiology 2000;62():237-60.
1999: SA Akhter; Andrea D Eckhart; Howard A Rockman; KF Shotwell; Robert J Lefkowitz; Walter J Koch
In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.
Circulation 1999;100(6):648-53.
1999: M C Cho; Antonio Rapacciuolo; Walter J Koch; Y Kobayashi; L R Jones; Howard A Rockman
Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression.
The Journal of biological chemistry 1999;274(32):22251-6.
1999: M C Cho; M Rao; Walter J Koch; S A Thomas; R D Palmiter; Howard A Rockman
Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.
Circulation 1999;99(20):2702-7.
1999: Walter J Koch; Howard A Rockman
Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.
Trends in cardiovascular medicine 1999;9(3-4):77-81.
1999: DJ Choi; Howard A Rockman
Beta-adrenergic receptor desensitization in cardiac hypertrophy and heart failure.
Cell biochemistry and biophysics 1999;31(3):321-9.
1998: guido iaccarino; Howard A Rockman; KF Shotwell; E D Tomhave; Walter J Koch
Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs.
The American journal of physiology 1998;275(4 Pt 2):H1298-306.
1998: N Tanaka; T Ryoke; M Hongo; L Mao; Howard A Rockman; R G Clark; John Ross
Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice.
The American journal of physiology 1998;275(2 Pt 2):H393-9.
1998: Howard A Rockman; DJ Choi; S A Akhter; M Jaber; Bruno GIROS; Robert J Lefkowitz; Marc G Caron; Walter J Koch
Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.
The Journal of biological chemistry 1998;273(29):18180-4.
1998: Howard A Rockman; Kenneth R Chien; DJ Choi; guido iaccarino; JJ Hunter; John Ross; Robert J Lefkowitz; Walter J Koch
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7000-5.
1998: SA Akhter; Louis M Luttrell; Howard A Rockman; guido iaccarino; Robert J Lefkowitz; Walter J Koch
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
Science (New York, N.Y.) 1998;280(5363):574-7.
1998: Walter J Koch; Robert J Lefkowitz; Carmelo A Milano; SA Akhter; Howard A Rockman
Myocardial overexpression of adrenergic receptors and receptor kinases.
Advances in pharmacology (San Diego, Calif.) 1998;42():502-6.
1997: Paula M Oliver; JE Fox; R Kim; Howard A Rockman; Hyung-Suk Kim; Robert L Reddick; Kailash N Pandey; Sharon L Milgram; Oliver Smithies; Nobuyo Maeda
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14730-5.
1997: SA Akhter; Carmelo A Milano; KF Shotwell; M C Cho; Howard A Rockman; Robert J Lefkowitz; Walter J Koch
Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.
The Journal of biological chemistry 1997;272(34):21253-9.
1997: H He; FJ Giordano; Randa Hilal-Dandan; DJ Choi; Howard A Rockman; Patrick M McDonough; Wolfgang F Bluhm; Markus Meyer; MR Sayen; Eric Swanson; Wolfgang H Dillmann
Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation.
The Journal of clinical investigation 1997;100(2):380-9.
1997: DJ Choi; Walter J Koch; JJ Hunter; Howard A Rockman
Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase.
The Journal of biological chemistry 1997;272(27):17223-9.
1997: Howard A Rockman; Walter J Koch; R J Lefkowitz
Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.
The American journal of physiology 1997;272(4 Pt 2):H1553-9.
1997: K H Ryu; N Tanaka; Nancy Dalton; L Mao; Howard A Rockman; C A Milano; John Ross
Force-frequency relations in the failing rabbit heart and responses to adrenergic stimulation.
Journal of cardiac failure 1997;3(1):27-39.
1997: P Samama; R A Bond; Howard A Rockman; Carmelo A Milano; Robert J Lefkowitz
Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):137-41.
1997: Howard A Rockman
Uncoupling of G-protein coupled receptors in vivo: insights from transgenic mice.
Advances in experimental medicine and biology 1997;430():67-72.
1996: G Lembo; Howard A Rockman; JJ Hunter; H Steinmetz; Walter J Koch; L Ma; M P Prinz; John Ross; Kenneth R Chien; L Powell-Braxton
Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.
The Journal of clinical investigation 1996;98(11):2648-55.
1996: Ghassan Jaber; Walter J Koch; Howard A Rockman; Bradley R Smith; Richard A Bond; Kathleen K Sulik; J Ross; R J Lefkowitz; Marc G Caron; Bruno GIROS
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):12974-9.
1996: Howard A Rockman; DJ Choi; N U Rahman; SA Akhter; R J Lefkowitz; Walter J Koch
Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9954-9.
1996: Howard A Rockman; Walter J Koch; Carmelo A Milano; R J Lefkowitz
Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.
Journal of molecular medicine (Berlin, Germany) 1996;74(9):489-95.
1996: N Tanaka; Nancy Dalton; L Mao; Howard A Rockman; K L Peterson; Kim Robin Gottshall; JJ Hunter; Kenneth R Chien; John Ross
Transthoracic echocardiography in models of cardiac disease in the mouse.
Circulation 1996;94(5):1109-17.
1996: Ori Ben-Yehuda; Howard A Rockman
Regulation of myocardial contractility: Insights from transgenic mice.
Trends in cardiovascular medicine 1996;6(3):95-9.
1996: Howard A Rockman; R A Hamilton; L R Jones; Carmelo A Milano; L Mao; R J Lefkowitz
Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.
The Journal of clinical investigation 1996;97(7):1618-23.
1995: JJ Hunter; N Tanaka; Howard A Rockman; John Ross; Kenneth R Chien
Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.
The Journal of biological chemistry 1995;270(39):23173-8.
1995: Kirk U Knowlton; Howard A Rockman; M Itani; A Vovan; C E Seidman; Kenneth R Chien
Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.
The Journal of clinical investigation 1995;96(3):1311-8.
1995: Walter J Koch; Howard A Rockman; P Samama; R A Hamilton; Richard A Bond; Carmelo A Milano; R J Lefkowitz
Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.
Science (New York, N.Y.) 1995;268(5215):1350-3.
1995: Richard A Bond; P Leff; T D Johnson; Carmelo A Milano; Howard A Rockman; T R McMinn; S Apparsundaram; M F Hyek; Terry Kenakin; L F Allen
Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor.
Nature 1995;374(6519):272-6.
1995: Carmelo A Milano; L F Allen; Paul C Dolber; T D Johnson; Howard A Rockman; Richard A Bond; R J Lefkowitz
Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.
The Journal of thoracic and cardiovascular surgery 1995;109(2):236-41.
1994: Carmelo A Milano; Paul C Dolber; Howard A Rockman; Richard A Bond; Mark E Venable; L F Allen; R J Lefkowitz
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):10109-13.
1994: Howard A Rockman; S P Wachhorst; L Mao; John Ross
ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice.
The American journal of physiology 1994;266(6 Pt 2):H2468-75.
1994: Carmelo A Milano; L F Allen; Howard A Rockman; Paul C Dolber; T R McMinn; K R Chien; T D Johnson; Richard A Bond; R J Lefkowitz
Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.
Science (New York, N.Y.) 1994;264(5158):582-6.
1994: Howard A Rockman; S Ono; R S Ross; L R Jones; M Karimi; V Bhargava; John Ross; Kenneth R Chien
Molecular and physiological alterations in murine ventricular dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2694-8.
1994: S Ono; V Bhargava; S Ono; L Mao; G Hagan; Howard A Rockman; John Ross
In vivo assessment of left ventricular remodelling after myocardial infarction by digital video contrast angiography in the rat.
Cardiovascular research 1994;28(3):349-57.
1994: Jeffrey H Omens; Howard A Rockman; James W Covell
Passive ventricular mechanics in tight-skin mice.
The American journal of physiology 1994;266(3 Pt 2):H1169-76.
1993: B H Oh; S Ono; Howard A Rockman; John Ross
Myocardial hypertrophy in the ischemic zone induced by exercise in rats after coronary reperfusion.
Circulation 1993;87(2):598-607.
1992: M Kambayashi; Toshiro Miura; B H Oh; K Murata; Howard A Rockman; G Parra; John Ross
Myocardial cell hypertrophy after myocardial infarction with reperfusion in dogs.
Circulation 1992;86(6):1935-44.
1992: B H Oh; M Volpini; M Kambayashi; K Murata; Howard A Rockman; G S Kassab; John Ross
Myocardial function and transmural blood flow during coronary venous retroperfusion in pigs.
Circulation 1992;86(4):1265-79.
1992: K J Lee; R S Ross; Howard A Rockman; A N Harris; Terrence X O'Brien; M van Bilsen; H E Shubeita; R Kandolf; G Brem; J Price
Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.
The Journal of biological chemistry 1992;267(22):15875-85.
1992: M Kambayashi; Toshiro Miura; B H Oh; Howard A Rockman; K Murata; John Ross
Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs.
Circulation 1992;86(2):572-80.
1992: Howard A Rockman; K U Knowlton
Peripartum vascular collapse Dissection of a genetic disease.
Trends in cardiovascular medicine 1992;2(4):125-8.
1991: Howard A Rockman; R S Ross; A N Harris; Kirk U Knowlton; M E Steinhelper; Loren J Field; John Ross; Kenneth R Chien
Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8277-81.