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Llewelyn Roderick

Research Profile

Physiology

Calcium Signaling

Chemicals & Drugs

Anatomy

Living Beings

Concepts & Ideas

Biological Models

Disorders

Myocardial Contraction

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Publications

TOP 3
Faye M Drawnel; Caroline R Archer; H Llewelyn Roderick
The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth.
Faye M Drawnel; Chihiro Hisatsune; Ning Liu; Marjorie Maillet; Katsuhiko Mikoshiba; Jeffery D Molkentin; hanneke okkenhaug; Simon R Andrews; Jan Magnus Aronsen; Martin D Bootman; Daniele Catalucci; Ivar Sjaastad; Fredrik Swift; Dagmar Wachten; H Llewelyn Roderick
Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy.
Rüdiger Thul; Stephen Coombes; H Llewelyn Roderick; Martin D Bootman
Subcellular calcium dynamics in a whole-cell model of an atrial myocyte.

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All Publications

2013: Faye M Drawnel; Caroline R Archer; H Llewelyn Roderick
The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth.
British journal of pharmacology 2013;168(2):296-317.
2012: Faye M Drawnel; Chihiro Hisatsune; Ning Liu; Marjorie Maillet; Katsuhiko Mikoshiba; Jeffery D Molkentin; hanneke okkenhaug; Simon R Andrews; Jan Magnus Aronsen; Martin D Bootman; Daniele Catalucci; Ivar Sjaastad; Fredrik Swift; Dagmar Wachten; H Llewelyn Roderick
Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy.
The Journal of cell biology 2012;199(5):783-98.
2012: Rüdiger Thul; Stephen Coombes; H Llewelyn Roderick; Martin D Bootman
Subcellular calcium dynamics in a whole-cell model of an atrial myocyte.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(6):2150-5.
2011: Claire J Fearnley; H Llewelyn Roderick; Martin D Bootman
Calcium signaling in cardiac myocytes.
Cold Spring Harbor perspectives in biology 2011;3(11):a004242.
2011: Martin D Bootman; Ioannis Smyrnias; Rüdiger Thul; Stephen Coombes; H Llewelyn Roderick
Atrial cardiomyocyte calcium signalling.
Biochimica et biophysica acta 2011;1813(5):922-34.
2011: Martin D Bootman; H Llewelyn Roderick
Using calcium imaging as a readout of GPCR activation.
Methods in molecular biology (Clifton, N.J.) 2011;746():277-96.
2010: Ioannis Smyrnias; Waltraud Mair; Dagmar Harzheim; Simon A Walker; H Llewelyn Roderick; Martin D Bootman
Comparison of the T-tubule system in adult rat ventricular and atrial myocytes, and its role in excitation-contraction coupling and inotropic stimulation.
Cell calcium 2010;47(3):210-23.
2010: Brian Yee Hong Lam; Wenting Zhang; David Chi-Heng Ng; Mahiben Maruthappu; H Llewelyn Roderick; Sangeeta Chawla
CREB-dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors.
Journal of neurochemistry 2010;112(4):1065-73.
2010: Rodney P O'Connor; Steve D Madison; Philippe Leveque; H Llewelyn Roderick; Martin D Bootman
Exposure to GSM RF fields does not affect calcium homeostasis in human endothelial cells, rat pheocromocytoma cells or rat hippocampal neurons.
PloS one 2010;5(7):e11828.
2010: Dagmar Harzheim; Amarnath Talasila; Mehregan Movassagh; Roger Foo; Nichola Figg; Martin D Bootman; H Llewelyn Roderick
Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes.
Channels (Austin, Tex.) 2010;4(1):67-71.
2009: Michael W Harr; Yiping Rong; Martin D Bootman; H Llewelyn Roderick; Clark W Distelhorst
Glucocorticoid-mediated inhibition of Lck modulates the pattern of T cell receptor-induced calcium signals by down-regulating inositol 1,4,5-trisphosphate receptors.
The Journal of biological chemistry 2009;284(46):31860-71.
2009: Yiping Rong; Geert Bultynck; Ademuyiwa S Aromolaran; Fei Zhong; Jan B Parys; Humbert De Smedt; Gregory A Mignery; H Llewelyn Roderick; Martin D Bootman; Clark W Distelhorst
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14397-402.
2009: Martin D Bootman; Claire Fearnley; Ioannis Smyrnias; Fraser MacDonald; H Llewelyn Roderick
An update on nuclear calcium signalling.
Journal of cell science 2009;122(Pt 14):2337-50.
2009: Dagmar Harzheim; Mehregan Movassagh; Roger Foo; Oliver Ritter; Aslam Tashfeen; Stuart Conway; Martin D Bootman; H Llewelyn Roderick
Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11406-11.
2009: Daniel R Higazi; Claire J Fearnley; Faye M Drawnel; Amarnath Talasila; Elaine M Corps; Oliver Ritter; Fraser McDonald; Katsuhiko Mikoshiba; Martin D Bootman; H Llewelyn Roderick
Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes.
Molecular cell 2009;33(4):472-82.
2008: C Jane Hanson; Martin D Bootman; Clark W Distelhorst; Richard J H Wojcikiewicz; H Llewelyn Roderick
Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content.
Cell calcium 2008;44(3):324-38.
2008: C Jane Hanson; Martin D Bootman; Clark W Distelhorst; Tullia Maraldi; H Llewelyn Roderick
The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effect.
Cell calcium 2008;44(3):243-58.
2008: Alexandra E Ewence; Martin Bootman; H Llewelyn Roderick; Jeremy N Skepper; Geraldine McCarthy; Matthias Epple; Markus Neumann; Catherine M Shanahan; Diane Proudfoot
Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization.
Circulation research 2008;103(5):e28-34.
2008: Elizabeth L Axe; Simon A Walker; Maria Manifava; Priya Chandra; H Llewelyn Roderick; Anja Habermann; Gareth Griffiths; Nicholas T Ktistakis
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum.
The Journal of cell biology 2008;182(4):685-701.
2008: Jens Kockskämper; Aleksey V Zima; H Llewelyn Roderick; Burkert Pieske; Lothar A Blatter; Martin D Bootman
Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes.
Journal of molecular and cellular cardiology 2008;45(2):128-47.
2008: Yiping Rong; Ademuyiwa S Aromolaran; Geert Bultynck; Fei Zhong; Xiang Li; Karen McColl; Shigemi Matsuyama; Stephan Herlitze; H Llewelyn Roderick; Martin D Bootman; Gregory A Mignery; Jan B Parys; Humbert De Smedt; Clark W Distelhorst
Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals.
Molecular cell 2008;31(2):255-65.
2008: H Llewelyn Roderick; Simon J Cook
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival.
Nature reviews. Cancer 2008;8(5):361-75.
2008: Tania Szado; Veerle Vanderheyden; Jan B Parys; Humbert De Smedt; Katja Rietdorf; Larissa Kotelevets; Eric Chastre; Farid Khan; Ulf Landegren; Ola Söderberg; Martin D Bootman; H Llewelyn Roderick
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2427-32.
2008: Martin D Bootman; H Llewelyn Roderick
Why, where, and when do cardiac myocytes express inositol 1,4,5-trisphosphate receptors?
American journal of physiology. Heart and circulatory physiology 2008;294(2):H579-81.
2008: Paul Cuddon; Martin D Bootman; Gillian R Richards; Alison J Smith; Peter B Simpson; H Llewelyn Roderick
Methacholine and PDGF activate store-operated calcium entry in neuronal precursor cells via distinct calcium entry channels.
Biological research 2008;41(2):183-95.
2008: Ruediger Thul; Tomas C Bellamy; H Llewelyn Roderick; Martin D Bootman; Stephen Coombes
Calcium oscillations.
Advances in experimental medicine and biology 2008;641():1-27.
2007: H Llewelyn Roderick; D R Higazi; Ioannis Smyrnias; C Fearnley; D Harzheim; Martin D Bootman
Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid.
Biochemical Society transactions 2007;35(Pt 5):957-61.
2007: Martin D Bootman; Dagmar Harzheim; Ioannis Smyrnias; Stuart Conway; H Llewelyn Roderick
Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1.
Cell calcium 2007;42(4-5):489-501.
2007: Russell G Jones; Thi Bui; Carl White; Muniswamy Madesh; Connie M Krawczyk; Tullia Lindsten; Brian Hawkins; Sara Kubek; Kenneth A Frauwirth; Y Lynn Wang; Stuart Conway; H Llewelyn Roderick; Martin D Bootman; Hao Shen; J Kevin Foskett; Craig Thompson
The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.
Immunity 2007;27(2):268-80.
2007: Davide Bello; Tashfeen Aslam; Geert Bultynck; Alexandra M Z Slawin; H Llewelyn Roderick; Martin D Bootman; Stuart Conway
Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate.
The Journal of organic chemistry 2007;72(15):5647-59.
2007: H Llewelyn Roderick; Martin D Bootman
Pacemaking, arrhythmias, inotropy and hypertrophy: the many possible facets of IP3 signalling in cardiac myocytes.
The Journal of physiology 2007;581(Pt 3):883-4.
2007: E McNeill; Stuart Conway; H Llewelyn Roderick; Martin D Bootman; Nancy Hogg
Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils.
Cell calcium 2007;41(2):107-21.
2007: Anthony M Holmes; H Llewelyn Roderick; Fraser McDonald; Martin D Bootman
Interaction between store-operated and arachidonate-activated calcium entry.
Cell calcium 2007;41(1):1-12.
2006: Martin D Bootman; Daniel R Higazi; Stephen Coombes; H Llewelyn Roderick
Calcium signalling during excitation-contraction coupling in mammalian atrial myocytes.
Journal of cell science 2006;119(Pt 19):3915-25.
2006: Andrew Proven; H Llewelyn Roderick; Stuart Conway; Michael J Berridge; Jeffrey K Horton; Stephen J Capper; Martin D Bootman
Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes.
Journal of cell science 2006;119(Pt 16):3363-75.
2006: Jeong Hee Hong; Seok Jun Moon; Hae Mi Byun; Min Seuk Kim; Hae Jo; Yun Soo Bae; Syng-Ill Lee; Martin D Bootman; H Llewelyn Roderick; Dong Min Shin; Jeong Taeg Seo
Critical role of phospholipase Cgamma1 in the generation of H2O2-evoked [Ca2+]i oscillations in cultured rat cortical astrocytes.
The Journal of biological chemistry 2006;281(19):13057-67.
2006: H Llewelyn Roderick; Martin D Bootman
New Ca2+ indicator has freedom to express.
Chemistry & biology 2006;13(5):463-4.
2006: Gillian R Richards; Alison J Smith; P Cuddon; Q P Ma; Mathew Leveridge; Julie Kerby; H Llewelyn Roderick; M D Bootman; Peter B Simpson
The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells.
Journal of neurochemistry 2006;97(1):201-10.
2005: Qing Liu; Simon A Walker; Dingcheng Gao; James A Taylor; Yan-Feng Dai; Rebecca S Arkell; Martin D Bootman; H Llewelyn Roderick; Peter J Cullen; Peter J Lockyer
CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.
The Journal of cell biology 2005;170(2):183-90.
2005: Sangwoo Shim; Eyleen L K Goh; Shaoyu Ge; Kurt A Sailor; Joseph P Yuan; H Llewelyn Roderick; Martin D Bootman; Paul F Worley; Hongjun Song; Guo-Li Ming
XTRPC1-dependent chemotropic guidance of neuronal growth cones.
Nature neuroscience 2005;8(6):730-5.
2005: H Llewelyn Roderick; Martin D Bootman
Redoxing calcium from the ER.
Cell 2005;120(1):4-5.
2004: Lauren Mackenzie; H Llewelyn Roderick; Michael J Berridge; Stuart Conway; Martin D Bootman
The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction.
Journal of cell science 2004;117(Pt 26):6327-37.
2004: C Jane Hanson; Martin D Bootman; H Llewelyn Roderick
Cell signalling: IP3 receptors channel calcium into cell death.
Current biology : CB 2004;14(21):R933-5.
2004: Claire M Peppiatt; Anthony M Holmes; Jeong Taeg Seo; Martin D Bootman; Tony J Collins; Fraser McDonald; H Llewelyn Roderick
Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells.
The Biochemical journal 2004;381(Pt 3):929-39.
2004: Rui Chen; Ignacio Valencia; Fei Zhong; Karen S McColl; H Llewelyn Roderick; Martin D Bootman; Michael J Berridge; Stuart Conway; Andrew B Holmes; Gregory A Mignery; Patricio Velez; Clark W Distelhorst
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.
The Journal of cell biology 2004;166(2):193-203.
2004: Sarah J Russell; Lloyd W Ruddock; Kirsi E H Salo; Jason D Oliver; Quentin P Roebuck; David H Llewellyn; H Llewelyn Roderick; Peppi Koivunen; Johanna Myllyharju; Stephen High
The primary substrate binding site in the b' domain of ERp57 is adapted for endoplasmic reticulum lectin association.
The Journal of biological chemistry 2004;279(18):18861-9.
2004: Nael Nadif Kasri; Anthony M Holmes; Geert Bultynck; Jan B Parys; Martin D Bootman; Katja Rietdorf; Ludwig Missiaen; Fraser McDonald; Humbert De Smedt; Stuart Conway; Andrew B Holmes; Michael J Berridge; H Llewelyn Roderick
Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.
The EMBO journal 2004;23(2):312-21.
2004: Lauren Mackenzie; H Llewelyn Roderick; Andrew Proven; Stuart Conway; Martin D Bootman
Inositol 1,4,5-trisphosphate receptors in the heart.
Biological research 2004;37(4):553-7.
2003: H Llewelyn Roderick; Martin D Bootman
Calcium influx: is Homer the missing link?
Current biology : CB 2003;13(24):R976-8.
2003: Clark W Distelhorst; H Llewelyn Roderick
Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2?
Biochemical Society transactions 2003;31(Pt 5):958-9.
2003: H Llewelyn Roderick; Martin D Bootman
Bi-directional signalling from the InsP3 receptor: regulation by calcium and accessory factors.
Biochemical Society transactions 2003;31(Pt 5):950-3.
2003: Michael J Berridge; Martin D Bootman; H Llewelyn Roderick
Calcium signalling: dynamics, homeostasis and remodelling.
Nature reviews. Molecular cell biology 2003;4(7):517-29.
2003: Claire M Peppiatt; Tony J Collins; Lauren Mackenzie; Stuart Conway; Andrew B Holmes; Martin D Bootman; Michael J Berridge; Jeong Taeg Seo; H Llewelyn Roderick
2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels.
Cell calcium 2003;34(1):97-108.
2003: H Llewelyn Roderick; Michael J Berridge; Martin D Bootman
Calcium-induced calcium release.
Current biology : CB 2003;13(11):R425.
2002: Martin D Bootman; Michael J Berridge; H Llewelyn Roderick
Calcium signalling: more messengers, more channels, more complexity.
Current biology : CB 2002;12(16):R563-5.
2002: Martin D Bootman; Tony J Collins; Lauren Mackenzie; H Llewelyn Roderick; Michael J Berridge; Claire M Peppiatt
2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(10):1145-50.
2002: Martin D Bootman; Michael J Berridge; H Llewelyn Roderick
Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7320-2.
1999: Jason D Oliver; H Llewelyn Roderick; David H Llewellyn; Stephen High
ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin.
Molecular biology of the cell 1999;10(8):2573-82.
1998: David H Llewellyn; H Llewelyn Roderick
Overexpression of calreticulin fails to abolish its induction by perturbation of normal ER function.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1998;76(5):875-80.
1997: David H Llewellyn; H Llewelyn Roderick; S Rose
KDEL receptor expression is not coordinatedly up-regulated with ER stress-induced reticuloplasmin expression in HeLa cells.
Biochemical and biophysical research communications 1997;240(1):36-40.
1997: H Llewelyn Roderick; Anthony K Campbell; David H Llewellyn
Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors.
FEBS letters 1997;405(2):181-5.