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Isabel Roditi

Research Profile

Chemicals & Drugs

Concepts & Ideas

Genes & Molecular Sequences

Disorders

Trypanosomiasis, African

Physiology

Procedures

Living Beings

Mouse
Cattle

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Publications

TOP 3
Gabriela Schumann Burkard; Bernd Schimanski; Patrícia Rosa de Araújo; Manfred Heller; Sandro Käser; Sebastian Knüsel; Arunasalam Naguleswaran; Isabel Roditi
Nucleolar proteins regulate stage-specific gene expression and ribosomal RNA maturation in Trypanosoma brucei.
Sabine Morand; Christina Kunz Renggli; Isabel Roditi; Erik Vassella
MAP kinase kinase 1 (MKK1) is essential for transmission of Trypanosoma brucei by Glossina morsitans.
Jan Mani; Pascale Pescher; Alvaro Acosta-Serrano; Andreas Güttinger; Manfred Heller; Bernd Schimanski; Gerald Späth; Isabel Roditi
Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery.

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2013: Gabriela Schumann Burkard; Bernd Schimanski; Patrícia Rosa de Araújo; Manfred Heller; Sandro Käser; Sebastian Knüsel; Arunasalam Naguleswaran; Isabel Roditi
Nucleolar proteins regulate stage-specific gene expression and ribosomal RNA maturation in Trypanosoma brucei.
Molecular microbiology 2013;88(4):827-40.
2012: Sabine Morand; Christina Kunz Renggli; Isabel Roditi; Erik Vassella
MAP kinase kinase 1 (MKK1) is essential for transmission of Trypanosoma brucei by Glossina morsitans.
Molecular and biochemical parasitology 2012;186(1):73-6.
2011: Jan Mani; Pascale Pescher; Alvaro Acosta-Serrano; Andreas Güttinger; Manfred Heller; Bernd Schimanski; Gerald Späth; Isabel Roditi
Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery.
PloS one 2011;6(7):e22463.
2011: Gabriela Schumann Burkard; Pascal Jutzi; Isabel Roditi
Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters.
Molecular and biochemical parasitology 2011;175(1):91-4.
2010: Christoph Wetterwald; Thomas Roth; Martha Kaeslin; Marc Annaheim; Gabriela Wespi; Manfred Heller; Pascal Mäser; Isabel Roditi; Rita Pfister-Wilhelm; Annie Bézier; Gabor Gyapay; Jean-Michel Drezen; Beatrice Lanzrein
Identification of bracovirus particle proteins and analysis of their transcript levels at the stage of virion formation.
The Journal of general virology 2010;91(Pt 10):2610-9.
2010: Eric Aeby; Elisabetta Ullu; Hasmik Yepiskoposyan; Bernd Schimanski; Isabel Roditi; Oliver Mühlemann; André Schneider
tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans.
Nucleic acids research 2010;38(17):5833-43.
2010: Daniel Nilsson; Kapila Gunasekera; Jan Mani; Magne Osteras; Laurent Farinelli; Loic Baerlocher; Isabel Roditi; Torsten Ochsenreiter
Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei.
PLoS pathogens 2010;6(8):e1001037.
2009: Simon Haenni; Erwin Studer; Gabriela Schumann Burkard; Isabel Roditi
Bidirectional silencing of RNA polymerase I transcription by a strand switch region in Trypanosoma brucei.
Nucleic acids research 2009;37(15):5007-18.
2009: Cristina M Fragoso; Gabriela Schumann Burkard; Michael Oberle; Christina Kunz Renggli; Karen Hilzinger; Isabel Roditi
PSSA-2, a membrane-spanning phosphoprotein of Trypanosoma brucei, is required for efficient maturation of infection.
PloS one 2009;4(9):e7074.
2009: Erik Vassella; Michael Oberle; Simon Urwyler; Christina Kunz Renggli; Erwin Studer; Andrew Hemphill; Cristina Fragoso; Peter Bütikofer; Reto Brun; Isabel Roditi
Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse.
PloS one 2009;4(2):e4493.
2008: Hanoch Goldshmidt; Lilach Sheiner; Peter Bütikofer; Isabel Roditi; Shai Uliel; Mark Günzel; Markus Engstler; Shulamit Michaeli
Role of protein translocation pathways across the endoplasmic reticulum in Trypanosoma brucei.
The Journal of biological chemistry 2008;283(46):32085-98.
2008: Isabel Roditi; Michael J Lehane
Interactions between trypanosomes and tsetse flies.
Current opinion in microbiology 2008;11(4):345-51.
2007: Iris Spoerri; Ruth Chadwick; Christina Kunz Renggli; Keith Matthews; Isabel Roditi; Gabriela Burkard
Role of the stage-regulated nucleoside transporter TbNT10 in differentiation and adenosine uptake in Trypanosoma brucei.
Molecular and biochemical parasitology 2007;154(1):110-4.
2007: Gabriela Burkard; Cristina M Fragoso; Isabel Roditi
Highly efficient stable transformation of bloodstream forms of Trypanosoma brucei.
Molecular and biochemical parasitology 2007;153(2):220-3.
2007: Andreas Güttinger; Claudia Schwab; Sabine Morand; Isabel Roditi; Erik Vassella
A mitogen-activated protein kinase of Trypanosoma brucei confers resistance to temperature stress.
Molecular and biochemical parasitology 2007;153(2):203-6.
2007: Simon Urwyler; Erwin Studer; Christina Kunz Renggli; Isabel Roditi
A family of stage-specific alanine-rich proteins on the surface of epimastigote forms of Trypanosoma brucei.
Molecular microbiology 2007;63(1):218-28.
2006: Simon Haenni; Christina Kunz Renggli; Cristina M Fragoso; Michael Oberle; Isabel Roditi
The procyclin-associated genes of Trypanosoma brucei are not essential for cyclical transmission by tsetse.
Molecular and biochemical parasitology 2006;150(2):144-56.
2006: Silvia Utz; Isabel Roditi; Christina Kunz Renggli; Igor Almeida; Alvaro Acosta-Serrano; Peter Bütikofer
Trypanosoma congolense procyclins: unmasking cryptic major surface glycoproteins in procyclic forms.
Eukaryotic cell 2006;5(8):1430-40.
2006: Debora Domenicali Pfister; Gabriela Burkard; Sabine Morand; Christina Kunz Renggli; Isabel Roditi; Erik Vassella
A Mitogen-activated protein kinase controls differentiation of bloodstream forms of Trypanosoma brucei.
Eukaryotic cell 2006;5(7):1126-35.
2005: Simon Urwyler; Erik Vassella; Jan Van Den Abbeele; Christina Kunz Renggli; Pat Blundell; J David Barry; Isabel Roditi
Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei.
PLoS pathogens 2005;1(3):e22.
2004: Manosree Chandra; Matthias Liniger; Laurence Tetley; Isabel Roditi; J David Barry
TsetseEP, a gut protein from the tsetse Glossina morsitans, is related to a major surface glycoprotein of trypanosomes transmitted by the fly and to the products of a Drosophila gene family.
Insect biochemistry and molecular biology 2004;34(11):1163-73.
2004: Matthias Liniger; Simon Urwyler; Erwin Studer; Michael Oberle; Christina Kunz Renggli; Isabel Roditi
Role of the N-terminal domains of EP and GPEET procyclins in membrane targeting and the establishment of midgut infections by Trypanosoma brucei.
Molecular and biochemical parasitology 2004;137(2):247-51.
2004: Erik Vassella; Matthias Probst; André Schneider; Erwin Studer; Christina Kunz Renggli; Isabel Roditi
Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes.
Molecular biology of the cell 2004;15(9):3986-93.
2004: Karin Asbeck; Ursula Kurath; Isabel Roditi; Wendy Gibson
Trypanosoma (Nannomonas) simiae and T. (N.) godfreyi have genes encoding glutamic acid and alanine-rich proteins.
Molecular and biochemical parasitology 2004;134(1):159-62.
2003: Matthias Liniger; Alvaro Acosta-Serrano; Jan Van Den Abbeele; Christina Kunz Renggli; Reto Brun; Paul T Englund; Isabel Roditi
Cleavage of trypanosome surface glycoproteins by alkaline trypsin-like enzyme(s) in the midgut of Glossina morsitans.
International journal for parasitology 2003;33(12):1319-28.
2003: Lesya M Pinchuk; Bobbie L Boyd; Emily F Kruger; Isabel Roditi; A Furger
Bovine dendritic cells generated from monocytes and bone marrow progenitors regulate immunoglobulin production in peripheral blood B cells.
Comparative immunology, microbiology and infectious diseases 2003;26(4):233-49.
2003: Erik Vassella; Peter Bütikofer; Markus Engstler; Jennifer Jelk; Isabel Roditi
Procyclin null mutants of Trypanosoma brucei express free glycosylphosphatidylinositols on their surface.
Molecular biology of the cell 2003;14(4):1308-18.
2003: Christian Flueck; Jean-Yves Salomone; Ursula Kurath; Isabel Roditi
Cycloheximide-mediated accumulation of transcripts from a procyclin expression site depends on the intergenic region.
Molecular and biochemical parasitology 2003;127(1):93-7.
2003: Peter Bütikofer; Jennifer Jelk; Tatiana Malherbe; Erik Vassella; Alvaro Acosta-Serrano; Christina Kunz Renggli; Reto Brun; Isabel Roditi
Phosphorylation of GPEET procyclin is not necessary for survival of Trypanosoma brucei procyclic forms in culture and in the tsetse fly midgut.
Molecular and biochemical parasitology 2003;126(2):287-91.
2002: Ingrid Müller; Debora Domenicali-Pfister; Isabel Roditi; Erik Vassella
Stage-specific requirement of a mitogen-activated protein kinase by Trypanosoma brucei.
Molecular biology of the cell 2002;13(11):3787-99.
2002: Isabel Roditi; Matthias Liniger
Dressed for success: the surface coats of insect-borne protozoan parasites.
Trends in microbiology 2002;10(3):128-34.
2002: Peter Bütikofer; Erik Vassella; Angela Mehlert; Michael A J Ferguson; Isabel Roditi
Characterisation and cellular localisation of a GPEET procyclin precursor in Trypanosoma brucei insect forms.
Molecular and biochemical parasitology 2002;119(1):87-95.
2002: Peter Bütikofer; Erik Vassella; Monika Boschung; Christina Kunz Renggli; Reto Brun; Terry W Pearson; Isabel Roditi
Glycosylphosphatidylinositol-anchored surface molecules of Trypanosoma congolense insect forms are developmentally regulated in the tsetse fly.
Molecular and biochemical parasitology 2002;119(1):7-16.
2001: A Furger; Thomas W Jungi; J Y Salomone; VE Weynants; Isabel Roditi
Stable expression of biologically active recombinant bovine interleukin-4 in Trypanosoma brucei.
FEBS letters 2001;508(1):90-4.
2001: Erik Vassella; Alvaro Acosta-Serrano; Erwin Studer; S H Lee; Paul T Englund; Isabel Roditi
Multiple procyclin isoforms are expressed differentially during the development of insect forms of Trypanosoma brucei.
Journal of molecular biology 2001;312(4):597-607.
2001: Matthias Liniger; K Bodenmüller; E Pays; Sabina Gallati; Isabel Roditi
Overlapping sense and antisense transcription units in Trypanosoma brucei.
Molecular microbiology 2001;40(4):869-78.
2001: Alvaro Acosta-Serrano; Erik Vassella; Matthias Liniger; Christina Kunz Renggli; Reto Brun; Isabel Roditi; Paul T Englund
The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1513-8.
2001: Peter Bütikofer; Tatiana Malherbe; Monika Boschung; Isabel Roditi
GPI-anchored proteins: now you see 'em, now you don't.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):545-8.
2000: Terry W Pearson; R P Beecroft; Susan C Welburn; S Ruepp; Isabel Roditi; Kuo-Yuan Hwa; Paul T Englund; C W Wells; Noel Murphy
The major cell surface glycoprotein procyclin is a receptor for induction of a novel form of cell death in African trypanosomes in vitro.
Molecular and biochemical parasitology 2000;111(2):333-49.
2000: K Asbeck; S Ruepp; Isabel Roditi; Wendy Gibson
GARP is highly conserved among Trypanosoma congolense Savannah, Forest and Kilifi subgroups.
Molecular and biochemical parasitology 2000;106(2):303-6.
2000: Erik Vassella; J V Den Abbeele; Peter Bütikofer; Christina Kunz Renggli; A Furger; Reto Brun; Isabel Roditi
A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia.
Genes & development 2000;14(5):615-26.
1999: S Sbicego; Erik Vassella; Ursula Kurath; B Blum; Isabel Roditi
The use of transgenic Trypanosoma brucei to identify compounds inducing the differentiation of bloodstream forms to procyclic forms.
Molecular and biochemical parasitology 1999;104(2):311-22.
1999: Isabel Roditi; C Clayton
An unambiguous nomenclature for the major surface glycoproteins of the procyclic form of Trypanosoma brucei.
Molecular and biochemical parasitology 1999;103(1):99-100.
1999: Peter Bütikofer; Erik Vassella; S Ruepp; Monika Boschung; G Civenni; Thomas Seebeck; Andrew Hemphill; N Mookherjee; Terry W Pearson; Isabel Roditi
Phosphorylation of a major GPI-anchored surface protein of Trypanosoma brucei during transport to the plasma membrane.
Journal of cell science 1999;112 ( Pt 11)():1785-95.
1999: S Ruepp; Ursula Kurath; Christina Kunz Renggli; Reto Brun; Isabel Roditi
Glutamic acid/alanine-rich protein from Trypanosoma congolense is the functional equivalent of 'EP' procyclin from Trypanosoma brucei.
Molecular and biochemical parasitology 1999;98(1):151-6.
1998: VE Weynants; D Gilson; A Furger; RA Collins; Pascal Mertens; Xavier De Bolle; V T Heussler; Isabel Roditi; Chris J Howard; A E Dobbelaere; Jean-Jacques LETESSON
Production and characterisation of monoclonal antibodies specific for bovine interleukin-4.
Veterinary immunology and immunopathology 1998;66(2):99-112.
1998: Isabel Roditi; A Furger; S Ruepp; N Schürch; Peter Bütikofer
Unravelling the procyclin coat of Trypanosoma brucei.
Molecular and biochemical parasitology 1998;91(1):117-30.
1997: N Schürch; A Furger; Ursula Kurath; Isabel Roditi
Contributions of the procyclin 3' untranslated region and coding region to the regulation of expression in bloodstream forms of Trypanosoma brucei.
Molecular and biochemical parasitology 1997;89(1):109-21.
1997: Thomas W Jungi; Marija Brcic; Heinz Sager; Dirk A E Dobbelaere; A Furger; Isabel Roditi
Antagonistic effects of IL-4 and interferon-gamma (IFN-gamma) on inducible nitric oxide synthase expression in bovine macrophages exposed to gram-positive bacteria.
Clinical and experimental immunology 1997;109(3):431-8.
1997: Peter Bütikofer; S Ruepp; Monika Boschung; Isabel Roditi
'GPEET' procyclin is the major surface protein of procyclic culture forms of Trypanosoma brucei brucei strain 427.
The Biochemical journal 1997;326 ( Pt 2)():415-23.
1997: A Furger; N Schürch; Ursula Kurath; Isabel Roditi
Elements in the 3' untranslated region of procyclin mRNA regulate expression in insect forms of Trypanosoma brucei by modulating RNA stability and translation.
Molecular and cellular biology 1997;17(8):4372-80.
1997: S Ruepp; A Furger; Ursula Kurath; Christina Kunz Renggli; Andrew Hemphill; Reto Brun; Isabel Roditi
Survival of Trypanosoma brucei in the tsetse fly is enhanced by the expression of specific forms of procyclin.
The Journal of cell biology 1997;137(6):1369-79.
1996: Erik Vassella; Isabel Roditi; R Braun
Heterogeneous transcripts of RIME/ingi retroposons in Trypanosoma brucei are unspliced.
Molecular and biochemical parasitology 1996;82(1):131-5.
1996: H Kaufmann; M Yamage; Isabel Roditi; Dirk A E Dobbelaere; J P Dubey; O J Holmdahl; A Trees; Bruno Gottstein
Discrimination of Neospora caninum from Toxoplasma gondii and other apicomplexan parasites by hybridization and PCR.
Molecular and cellular probes 1996;10(4):289-97.
1996: C E Stebeck; U Frevert; Thomas Mommsen; Erik Vassella; Isabel Roditi; Terry W Pearson
Molecular characterization of glycosomal NAD(+)-dependent glycerol 3-phosphate dehydrogenase from Trypanosoma brucei rhodesiense.
Molecular and biochemical parasitology 1996;76(1-2):145-58.
1995: Adrian Hehl; Terry W Pearson; J D Barry; R Braun; Isabel Roditi
Expression of GARP, a major surface glycoprotein of Trypanosoma congolense, on the surface of Trypanosoma brucei: characterization and use as a selectable marker.
Molecular and biochemical parasitology 1995;70(1-2):45-58.
1994: Adrian Hehl; Isabel Roditi
The regulation of procyclin expression in Trypanosoma bruceli: making or breaking the rules?
Parasitology today (Personal ed.) 1994;10(11):442-5.
1994: N Schürch; Adrian Hehl; Erik Vassella; R Braun; Isabel Roditi
Accurate polyadenylation of procyclin mRNAs in Trypanosoma brucei is determined by pyrimidine-rich elements in the intergenic regions.
Molecular and cellular biology 1994;14(6):3668-75.
1994: M Affolter; Andrew Hemphill; Isabel Roditi; Norbert Müller; Thomas Seebeck
The repetitive microtubule-associated proteins MARP-1 and MARP-2 of Trypanosoma brucei.
Journal of structural biology 1994;112(3):241-51.
1994: Erik Vassella; R Braun; Isabel Roditi
Control of polyadenylation and alternative splicing of transcripts from adjacent genes in a procyclin expression site: a dual role for polypyrimidine tracts in trypanosomes?
Nucleic acids research 1994;22(8):1359-64.
1994: Isabel Roditi; T Wyler; N Smith; R Braun
Virus-like particles in Eimeria nieschulzi are associated with multiple RNA segments.
Molecular and biochemical parasitology 1994;63(2):275-82.
1994: Adrian Hehl; Erik Vassella; R Braun; Isabel Roditi
A conserved stem-loop structure in the 3' untranslated region of procyclin mRNAs regulates expression in Trypanosoma brucei.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):370-4.
1993: R P Beecroft; Isabel Roditi; Terry W Pearson
Identification and characterization of an acidic major surface glycoprotein from procyclic stage Trypanosoma congolense.
Molecular and biochemical parasitology 1993;61(2):285-94.
1993: U Stucki; R Braun; Isabel Roditi
Eimeria tenella: characterization of a 5S ribosomal RNA repeat unit and its use as a species-specific probe.
Experimental parasitology 1993;76(1):68-75.
1992: E Koenig-Martin; M Yamage; Isabel Roditi
A procyclin-associated gene in Trypanosoma brucei encodes a polypeptide related to ESAG 6 and 7 proteins.
Molecular and biochemical parasitology 1992;55(1-2):135-45.
1991: Dirk A E Dobbelaere; Isabel Roditi; T M Coquerelle; C Kelke; M Eichhorn; R O Williams
Lymphocytes infected with Theileria parva require both cell-cell contact and growth factor to proliferate.
European journal of immunology 1991;21(1):89-95.
1990: Dirk A E Dobbelaere; T D Prospero; Isabel Roditi; C Kelke; I Baumann; M Eichhorn; R O Williams; J S Ahmed; C L Baldwin; H Clevers
Expression of Tac antigen component of bovine interleukin-2 receptor in different leukocyte populations infected with Theileria parva or Theileria annulata.
Infection and immunity 1990;58(12):3847-55.
1990: Isabel Roditi; Terry W Pearson
The procyclin coat of African trypanosomes (or the not-so-naked trypanosome).
Parasitology today (Personal ed.) 1990;6(3):79-82.
1989: Isabel Roditi; E König; R O Williams
A rapid method for determining the orientation of inserts in bacteriophage lambda vectors.
Nucleic acids research 1989;17(24):10506.
1989: E König; H Delius; M Carrington; R O Williams; Isabel Roditi
Duplication and transcription of procyclin genes in Trypanosoma brucei.
Nucleic acids research 1989;17(21):8727-39.
1989: Isabel Roditi; Dirk A E Dobbelaere; R O Williams; W Masterson; R P Beecroft; J P Richardson; Terry W Pearson
Expression of Trypanosoma brucei procyclin as a fusion protein in Escherichia coli.
Molecular and biochemical parasitology 1989;34(1):35-43.
1989: Isabel Roditi; H Schwarz; Terry W Pearson; R P Beecroft; M K Liu; J P Richardson; H J Bühring; Juergen Pleiss; R Bülow; R O Williams
Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei.
The Journal of cell biology 1989;108(2):737-46.
1988: Dirk A E Dobbelaere; T M Coquerelle; Isabel Roditi; M Eichhorn; R O Williams
Theileria parva infection induces autocrine growth of bovine lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4730-4.