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Cecília Rodrigues

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Simone Pinton; Rita M Ramalho; Cecília M P Rodrigues; Marcel H M Sari; Ana Cristina Souza; Cristina W Nogueira
p,p'-Methoxyl-diphenyl diselenide protects against amyloid-β induced cytotoxicity in vitro and improves memory deficits in vivo.
Diane M Pereira; Pedro Borralho; Pedro M Rodrigues; Cecília M P Rodrigues
Delivering the promise of miRNA cancer therapeutics.
Daniela M Santos; Maria M M Santos; Susana Solá; Rui Moreira; Cecília M P Rodrigues
Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state.

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2013: Simone Pinton; Rita M Ramalho; Cecília M P Rodrigues; Marcel H M Sari; Ana Cristina Souza; Cristina W Nogueira
p,p'-Methoxyl-diphenyl diselenide protects against amyloid-β induced cytotoxicity in vitro and improves memory deficits in vivo.
Behavioural brain research 2013;247():241-7.
2013: Diane M Pereira; Pedro Borralho; Pedro M Rodrigues; Cecília M P Rodrigues
Delivering the promise of miRNA cancer therapeutics.
Drug discovery today 2013;18(5-6):282-9.
2013: Daniela M Santos; Maria M M Santos; Susana Solá; Rui Moreira; Cecília M P Rodrigues
Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state.
Molecular neurobiology 2013;47(1):313-24.
2013: Adrian C Lo; Ana F Nunes; Cecília M P Rodrigues; Zsuzsanna Callaerts-Vegh; Rudi D'Hooge
Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice.
Neurobiology of disease 2013;50():21-9.
2013: Rita M Ramalho; Ana M Sebastião; Joana D Amaral; Rudi D'Hooge; Raquel B Dias; Adrian C Lo; Ana F Nunes; Cecília M P Rodrigues
Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice.
Neurobiology of aging 2013;34(2):551-61.
2013: André E S Simões; Clifford J Steer; Stephen N Thibodeau; Pedro M Rodrigues; Joana D Amaral; Pedro Borralho; Rudi D'Hooge; Sofia E Gomes; Adrian C Lo; Ana F Nunes; Diane M Pereira; Cecília M P Rodrigues
Efficient recovery of proteins from multiple source samples after TRIzol(®) or TRIzol(®)LS RNA extraction and long-term storage.
BMC genomics 2013;14():181.
2013: Maria João Nunes; Cecília M P Rodrigues; Maria João Gama; Miguel Moutinho; Elsa Rodrigues
Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux.
PloS one 2013;8(1):e53394.
2013: Susana Solá; Ana L Morgado; Cecília M P Rodrigues
Death receptors and mitochondria: two prime triggers of neural apoptosis and differentiation.
Biochimica et biophysica acta 2013;1830(1):2160-6.
2013: Simone Pinton; Rita M Ramalho; Cecília M P Rodrigues; Tuane Bazanella Sampaio; Cristina Wayne Nogueira
p,p'-Methoxyl-diphenyl diselenide prevents neurodegeneration and glial cell activation induced by streptozotocin in rats.
Journal of Alzheimer's disease : JAD 2013;33(1):133-44.
2013: Rui E Castro; Helena Cortez-Pinto; Duarte M S Ferreira; Mariana V Machado; Marta B Afonso; Pedro Borralho; Cecília M P Rodrigues
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease.
Journal of hepatology 2013;58(1):119-25.
2012: Telma F S Silva; Cecília M P Rodrigues; Susana Santos; Ana Silva; Pedro M Borralho; Alexandra R Fernandes; M Fátima C Guedes da Silva; Luísa M D R S Martins; Armando J L Pombeiro
Cobalt complexes bearing scorpionate ligands: synthesis, characterization, cytotoxicity and DNA cleavage.
Dalton transactions (Cambridge, England : 2003) 2012;41(41):12888-97.
2012: Ricardo J S Viana; Ana F Nunes; Cecília M P Rodrigues
Endoplasmic reticulum enrollment in Alzheimer's disease.
Molecular neurobiology 2012;46(2):522-34.
2012: Rui E Castro; Cecília M P Rodrigues
Targeting miR-506 in primary biliary cirrhosis to support the HCO3- umbrella.
Clinics and research in hepatology and gastroenterology 2012;36(5):402-4.
2012: Susana Solá; Márcia M Aranha; Cecília M P Rodrigues
Driving apoptosis-relevant proteins toward neural differentiation.
Molecular neurobiology 2012;46(2):316-31.
2012: Ana F Nunes; Ricardo J S Viana; Joana D Amaral; Zsuzsanna Callaerts-Vegh; Rudi D'Hooge; Maria B Fonseca; Adrian C Lo; Cecília M P Rodrigues
TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice.
Molecular neurobiology 2012;45(3):440-54.
2012: Tayyab A Mansoor; Rita M Ramalho; Cecília M P Rodrigues; Maria-José Umbelino Ferreira
Dibenzylbutane- and butyrolactone-type lignans as apoptosis inducers in human hepatoma HuH-7 cells.
Phytotherapy research : PTR 2012;26(5):692-6.
2012: Maria B Fonseca; Ana L Morgado; Ana F Nunes; Susana Solá; Cecília M P Rodrigues
TAp63γ demethylation regulates protein stability and cellular distribution during neural stem cell differentiation.
PloS one 2012;7(12):e52417.
2012: Sandeep Gupta; Tarundeep Kaur; Shunan Li; Behzad Najafian; Kajohnsak Noppakun; Cecília M P Rodrigues; Md Joynal Abedin; Lawrence Wang; Clifford J Steer
Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models.
PloS one 2012;7(11):e48950.
2012: Daniela M Santos; Susana Solá; Joana M Xavier; Ana L Morgado; Cecília M P Rodrigues
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.
PloS one 2012;7(3):e33468.
2012: Mariana Verdelho Machado; Cecília M P Rodrigues; Ana Rita Silvestre; Fátima Carepa; Rui E Castro; Adília Costa; João Coutinho; Teresinha Evangelista; Duarte M S Ferreira; Helena Cortez-Pinto
Liver and muscle in morbid obesity: the interplay of fatty liver and insulin resistance.
PloS one 2012;7(2):e31738.
2012: Maria B Fonseca; Ana F Nunes; Cecília M P Rodrigues
c-Jun regulates the stability of anti-apoptotic ΔNp63 in amyloid-β-induced apoptosis.
Journal of Alzheimer's disease : JAD 2012;28(3):685-94.
2011: Tayyab A Mansoor; Cátia Ramalhete; Rita M Ramalho; Cecília M P Rodrigues; Xuan Luo; Maria-José Umbelino Ferreira
Isoflavones as apoptosis inducers in human hepatoma HuH-7 cells.
Phytotherapy research : PTR 2011;25(12):1819-24.
2011: Paula A Lopes; Susana V Martins; Mário S Pinho; Cristina M Alfaia; R J B Bessa; Matilde F Castro; Eliana Jerónimo; Rita M Ramalho; Cecília M P Rodrigues; Ricardo S J Viana; José A M Prates
Contrasting apoptotic responses of conjugated linoleic acid in the liver of obese Zucker rats fed palm oil or ovine fat.
Prostaglandins, leukotrienes, and essential fatty acids 2011;85(2):89-96.
2011: Pedro Borralho; Tânia Carvalho; Rui E Castro; Duarte M S Ferreira; Sofia E Gomes; Raquel T Lima; André E S Simões; Maria H Vasconcelos; Cecília M P Rodrigues
miR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation.
PloS one 2011;6(8):e23787.
2011: Márcia M Aranha; Daniela M Santos; Susana Solá; Clifford J Steer; Cecília M P Rodrigues
miR-34a regulates mouse neural stem cell differentiation.
PloS one 2011;6(8):e21396.
2011: Ricardo J S Viana; Clifford J Steer; Cecília M P Rodrigues
Amyloid-β peptide-induced secretion of endoplasmic reticulum chaperone glycoprotein GRP94.
Journal of Alzheimer's disease : JAD 2011;27(1):61-73.
2011: Susana Solá; Joana M Xavier; Daniela M Santos; Márcia M Aranha; Ana L Morgado; Kristen Jepsen; Cecília M P Rodrigues
p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation.
PloS one 2011;6(3):e18421.
2010: Ricardo J S Viana; Maria B Fonseca; Rita M Ramalho; Ana F Nunes; Cecília M P Rodrigues
Organelle stress sensors and cell death mechanisms in neurodegenerative diseases.
CNS & neurological disorders drug targets 2010;9(6):679-92.
2010: Joana D Amaral; Rui E Castro; Susana Solá; Clifford J Steer; Cecília M P Rodrigues
Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53.
Biochemical and biophysical research communications 2010;400(4):649-54.
2010: Rui E Castro; Duarte M S Ferreira; Xiaoxiao Zhang; Pedro Borralho; Aaron L Sarver; Yan Zeng; Clifford J Steer; Betsy T Kren; Cecília M P Rodrigues
Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(4):G887-97.
2010: Joana D Amaral; Ana R Correia; Clifford J Steer; Cláudio M. Gomes; Cecília M P Rodrigues
No evidence of direct binding between ursodeoxycholic acid and the p53 DNA-binding domain.
Bioscience reports 2010;30(5):359-64.
2010: Joana D Amaral; Joana M Xavier; Clifford J Steer; Cecília M P Rodrigues
The role of p53 in apoptosis.
Discovery medicine 2010;9(45):145-52.
2010: Paula Ravasco; Márcia M Aranha; Pedro M Borralho; Isabel B Moreira da Silva; Luís Correia; Afonso Fernandes; Cecília M P Rodrigues; Maria Ermelinda Camilo
Colorectal cancer: can nutrients modulate NF-kappaB and apoptosis?
Clinical nutrition (Edinburgh, Scotland) 2010;29(1):42-6.
2010: Márcia M Aranha; Daniela M Santos; Joana M Xavier; Walter C Low; Clifford J Steer; Susana Solá; Cecília M P Rodrigues
Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation.
BMC genomics 2010;11():514.
2010: Ricardo J S Viana; Rita M Ramalho; Ana F Nunes; Clifford J Steer; Cecília M P Rodrigues
Modulation of amyloid-β peptide-induced toxicity through inhibition of JNK nuclear localization and caspase-2 activation.
Journal of Alzheimer's disease : JAD 2010;22(2):557-68.
2010: Rui E Castro; Maria M M Santos; Paulo M C Glória; Carlos J A Ribeiro; Duarte M S Ferreira; Joana M Xavier; Rui Moreira; Cecília M P Rodrigues
Cell death targets and potential modulators in Alzheimer's disease.
Current pharmaceutical design 2010;16(25):2851-64.
2010: Joana D Amaral; Joana M Xavier; Clifford J Steer; Cecília M P Rodrigues
Targeting the p53 pathway of apoptosis.
Current pharmaceutical design 2010;16(22):2493-503.
2009: Pedro M Borralho; Betsy T Kren; Rui E Castro; Isabel B Moreira da Silva; Clifford J Steer; Cecília M P Rodrigues
MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.
The FEBS journal 2009;276(22):6689-700.
2009: Joana D Amaral; Rui E Castro; Clifford J Steer; Cecília M P Rodrigues
p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis.
Trends in molecular medicine 2009;15(11):531-41.
2009: Joana D Amaral; Ricardo J S Viana; Rita M Ramalho; Clifford J Steer; Cecília M P Rodrigues
Bile acids: regulation of apoptosis by ursodeoxycholic acid.
Journal of lipid research 2009;50(9):1721-34.
2009: Tayyab A Mansoor; Rita M Ramalho; Silva Mulhovo; Cecília M P Rodrigues; Maria-José Umbelino Ferreira
Induction of apoptosis in HuH-7 cancer cells by monoterpene and beta-carboline indole alkaloids isolated from the leaves of Tabernaemontana elegans.
Bioorganic & medicinal chemistry letters 2009;19(15):4255-8.
2009: Daniela M Santos; Maria M M Santos; Ricardo J S Viana; Rui E Castro; Rui Moreira; Cecília M P Rodrigues
Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: potent, non-cytotoxic, antiapoptotic agents.
Chemico-biological interactions 2009;180(2):175-82.
2009: Márcia M Aranha; Susana Solá; Walter C Low; Clifford J Steer; Cecília M P Rodrigues
Caspases and p53 modulate FOXO3A/Id1 signaling during mouse neural stem cell differentiation.
Journal of cellular biochemistry 2009;107(4):748-58.
2009: R J S Viana; A F Nunes; Rui E Castro; Rita M Ramalho; J Meyerson; S Fossati; Jorge Ghiso; Agueda Rostagno; Cecília M P Rodrigues
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.
Cellular and molecular life sciences : CMLS 2009;66(6):1094-104.
2009: Aaron L Sarver; Amy J French; Pedro Borralho; Venugopal Thayanithy; Ann L Oberg; Kevin A T Silverstein; Bruce W Morlan; Shaun M Riska; Lisa A Boardman; Julie M Cunningham; Subbaya Subramanian; Liang Wang; Tom C Smyrk; Cecília M P Rodrigues; Stephen N Thibodeau; Clifford J Steer
Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states.
BMC cancer 2009;9():401.
2009: Joana D Amaral; Susana Solá; Clifford J Steer; Cecília M P Rodrigues
Role of nuclear steroid receptors in apoptosis.
Current medicinal chemistry 2009;16(29):3886-902.
2008: Márcia M Aranha; Helena Cortez-Pinto; Adília Costa; Isabel B Moreira da Silva; Maria Ermelinda Camilo; Miguel Carneiro de Moura; Cecília M P Rodrigues
Bile acid levels are increased in the liver of patients with steatohepatitis.
European journal of gastroenterology & hepatology 2008;20(6):519-25.
2008: Rita M Ramalho; Ricardo J S Viana; Rui E Castro; Clifford J Steer; Walter C Low; Cecília M P Rodrigues
Apoptosis in transgenic mice expressing the P301L mutated form of human tau.
Molecular medicine (Cambridge, Mass.) 2008;14(5-6):309-17.
2008: Rita M Ramalho; Ricardo J S Viana; Walter C Low; Clifford J Steer; Cecília M P Rodrigues
Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease.
Trends in molecular medicine 2008;14(2):54-62.
2007: Joana D Amaral; Rui E Castro; Susana Solá; Clifford J Steer; Cecília M P Rodrigues
p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis.
The Journal of biological chemistry 2007;282(47):34250-9.
2007: GM Ferreira-Dias; L Mateus; A S Costa; Susana Solá; Rita M Ramalho; Rui E Castro; Cecília M P Rodrigues
Progesterone and caspase-3 activation in equine cyclic corpora lutea.
Reproduction in domestic animals = Zuchthygiene 2007;42(4):380-6.
2007: Susana Solá; Márcia M Aranha; Clifford J Steer; Cecília M P Rodrigues
Game and players: mitochondrial apoptosis and the therapeutic potential of ursodeoxycholic acid.
Current issues in molecular biology 2007;9(2):123-38.
2007: Rui E Castro; Joana D Amaral; Susana Solá; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G327-34.
2007: Márcia M Aranha; Ana Rita Matos; Ana Mendes; Vera Vaz Pinto; Cecília M P Rodrigues; João D Arrabaça
Dinitro-o-cresol induces apoptosis-like cell death but not alternative oxidase expression in soybean cells.
Journal of plant physiology 2007;164(6):675-84.
2007: Márcia M Aranha; Pedro Borralho; Paula Ravasco; I B Moreira da Silva; Ludovic Correia; A Fernandes; Maria Ermelinda Camilo; Cecília M P Rodrigues
NF-kappaB and apoptosis in colorectal tumourigenesis.
European journal of clinical investigation 2007;37(5):416-24.
2007: Andrew Rivard; Clifford J Steer; Betsy T Kren; Cecília M P Rodrigues; Rui E Castro; Richard W Bianco; Walter C Low
Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat.
The American journal of Chinese medicine 2007;35(2):279-95.
2007: Pedro Borralho; Isabel B Moreira da Silva; Márcia M Aranha; Cristina Albuquerque; Carlos Nobre-Leitão; Clifford J Steer; Cecília M P Rodrigues
Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53.
Biochimica et biophysica acta 2007;1772(1):40-7.
2006: Susana Solá; Joana D Amaral; Pedro Borralho; Rita M Ramalho; Rui E Castro; Márcia M Aranha; Clifford J Steer; Cecília M P Rodrigues
Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis.
Molecular endocrinology (Baltimore, Md.) 2006;20(10):2292-303.
2006: Rita M Ramalho; Pedro Borralho; Rui E Castro; Susana Solá; Clifford J Steer; Cecília M P Rodrigues
Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells.
Journal of neurochemistry 2006;98(5):1610-8.
2006: Cecília M P Rodrigues; Clifford J Steer
Fooling the Fas ligand in death.
Hepatology (Baltimore, Md.) 2006;44(2):314-7.
2006: Wei Zhang; Clifford J Steer; Kenneth T Douglas; Cecília M P Rodrigues
Binding studies of bile acids using the native fluorescence of the tryptophan residue Of Bax protein.
Bioscience reports 2006;26(3):245-50.
2006: Susana Solá; David L Garshelis; Joana D Amaral; Karen V Noyce; Pam L Coy; Clifford J Steer; Paul A Iaizzo; Cecília M P Rodrigues
Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus: seasonal changes.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2006;143(2):204-8.
2006: Jeffrey H Boatright; Anisha G Moring; Clinton McElroy; Michael J Phillips; Vi T Do; Bo Chang; Norman L Hawes; Amber P Boyd; Sheree S Sidney; Rachael E Stewart; Steven C Minear; Rajashree Chaudhury; Vincent T Ciavatta; Cecília M P Rodrigues; Clifford J Steer; John M Nickerson; Machelle T Pardue
Tool from ancient pharmacopoeia prevents vision loss.
Molecular vision 2006;12():1706-14.
2006: Susana Solá; Joana D Amaral; Márcia M Aranha; Clifford J Steer; Cecília M P Rodrigues
Modulation of hepatocyte apoptosis: cross-talk between bile acids and nuclear steroid receptors.
Current medicinal chemistry 2006;13(25):3039-51.
2006: Rita M Ramalho; Helena Cortez-Pinto; Rui E Castro; Susana Solá; Adília Costa; Miguel C Moura; Maria Ermelinda Camilo; Cecília M P Rodrigues
Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis.
European journal of gastroenterology & hepatology 2006;18(1):21-9.
2005: Rina Ved; Shamol Saha; Beth Westlund; Celine Perier; Lucinda Burnam; Anne Sluder; Marius Hoener; Cecília M P Rodrigues; Aixa Alfonso; Clifford Steer; Leo Liu; Serge Przedborski; Benjamin Wolozin
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
The Journal of biological chemistry 2005;280(52):42655-68.
2005: Susana Solá; Joana D Amaral; Rui E Castro; Rita M Ramalho; Pedro Borralho; Betsy T Kren; Hirotoshi Tanaka; Clifford J Steer; Cecília M P Rodrigues
Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes.
Hepatology (Baltimore, Md.) 2005;42(4):925-34.
2005: Rui E Castro; Susana Solá; Xiaoming Ma; Rita M Ramalho; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid.
Journal of hepatology 2005;42(6):897-906.
2005: Frank-Peter Wachs; Rene C Krieg; Cecília M P Rodrigues; Helmut Messmann; Frank Kullmann; Ruth Knüchel-Clarke; Jürgen Schölmerich; Gerhard Rogler; Klaus Schlottmann
Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor.
International journal of colorectal disease 2005;20(2):103-13.
2004: Rui E Castro; Susana Solá; Rita M Ramalho; Clifford J Steer; Cecília M P Rodrigues
The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons.
The Journal of pharmacology and experimental therapeutics 2004;311(2):845-52.
2004: Paulo S Ribeiro; Helena Cortez-Pinto; Susana Solá; Rui E Castro; Rita M Ramalho; Amélia Baptista; Miguel C Moura; Maria Ermelinda Camilo; Cecília M P Rodrigues
Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients.
The American journal of gastroenterology 2004;99(9):1708-17.
2004: Rita M Ramalho; Paulo S Ribeiro; Susana Solá; Rui E Castro; Clifford J Steer; Cecília M P Rodrigues
Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells.
Journal of neurochemistry 2004;90(3):567-75.
2004: Susana Solá; Rui E Castro; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes.
Biochemistry 2004;43(26):8429-38.
2004: G Fan; X Ma; P Y Wong; Cecília M P Rodrigues; C J Steer
p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells.
Apoptosis : an international journal on programmed cell death 2004;9(2):211-21.
2003: Susana Sola; Xiaoming Ma; Rui E Castro; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes.
The Journal of biological chemistry 2003;278(49):48831-8.
2003: Susana Solá; Rui E Castro; Pedro Laires; Clifford J Steer; Cecília M P Rodrigues
Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway.
Molecular medicine (Cambridge, Mass.) 2003;9(9-12):226-34.
2003: Cecília M P Rodrigues; Susana Sola; Zhenhong Nan; Rui E Castro; Paulo S Ribeiro; Walter C Low; Clifford J Steer
Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6087-92.
2003: Cecília M P Rodrigues; Susana Solá; Juanita C Sharpe; José J G Moura; Clifford J Steer
Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria.
Biochemistry 2003;42(10):3070-80.
2002: Susana Solá; Maria A Brito; Dora Brites; José J G Moura; Cecília M P Rodrigues
Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes.
Clinical science (London, England : 1979) 2002;103(5):475-85.
2002: C Dirk Keene; Cecília M P Rodrigues; Tacjana Eich; Manik S Chhabra; Clifford J Steer; Walter C Low
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10671-6.
2002: Susana Solá; Maria José Oliveira Dógenes; Dora Brites; Cecília M P Rodrigues
[Release of cytochrome C with the interaction of bilirubin, amyloid beta-peptide and glycochenodeoxycholate from isolated mitochondria].
Acta médica portuguesa 2002;15(4):269-75.
2002: Cecília M P Rodrigues; Susana Solá; Rui E Castro; Pedro Laires; Dora Brites; José J G Moura
Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis.
Journal of lipid research 2002;43(6):885-94.
2002: Cecília M P Rodrigues; Susana Solá; Dora Brites
Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons.
Hepatology (Baltimore, Md.) 2002;35(5):1186-95.
2002: Cecília M P Rodrigues; Stephen R Spellman; Susana Solá; Andrew W Grande; Cheryle Linehan-Stieers; Walter C Low; Clifford J Steer
Neuroprotection by a bile acid in an acute stroke model in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(4):463-71.
2002: Rui FM Silva; Cecília M P Rodrigues; Dora Brites
Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin.
Pediatric research 2002;51(4):535-41.
2002: Cecília M P Rodrigues; Susana Solá; Maria A Brito; Dora Brites; José J G Moura
Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria.
Journal of hepatology 2002;36(3):335-41.
2002: Wei-Ming Duan; Cecília M P Rodrigues; Li-Ru Zhao; Clifford J Steer; Walter C Low; Cecilia M P Rodrigures
Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease.
Cell transplantation 2002;11(3):195-205.
2002: Cecília M P Rodrigues; Susana Solá; Rui FM Silva; Dora Brites
Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin.
Pediatric research 2002;51(1):112-8.
2001: C Dirk Keene; Cecília M P Rodrigues; T Eich; Cheryle Linehan-Stieers; A Abt; Betsy T Kren; Clifford J Steer; Walter C Low
A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease.
Experimental neurology 2001;171(2):351-60.
2001: Cecília M P Rodrigues; Clifford J Steer
The therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agent.
Expert opinion on investigational drugs 2001;10(7):1243-53.
2001: Betsy T Kren; Cecília M P Rodrigues; K D Setchell; Clifford J Steer
Modulation of steady-state messenger RNA levels in the regenerating rat liver with bile acid feeding.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2001;7(4):321-34.
2001: Rui FM Silva; Cecília M P Rodrigues; Dora Brites
Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid.
Journal of hepatology 2001;34(3):402-8.
2001: Cecília M P Rodrigues; Susana Solá; Maria A Brito; C D Brondino; Dora Brites; José J G Moura
Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate.
Biochemical and biophysical research communications 2001;281(2):468-74.
2000: Cecília M P Rodrigues; C L Stieers; C Dirk Keene; X Ma; Betsy T Kren; Walter C Low; Clifford J Steer
Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition.
Journal of neurochemistry 2000;75(6):2368-79.
2000: Cecília M P Rodrigues; Susana Solá; R Silva; Dora Brites
Bilirubin and amyloid-beta peptide induce cytochrome c release through mitochondrial membrane permeabilization.
Molecular medicine (Cambridge, Mass.) 2000;6(11):936-46.
2000: Cecília M P Rodrigues; Dora Brites; Fátima Serejo; Adilia Costa; Fernando Ramalho; Miguel Carneiro de Moura
Apoptotic cell death does not parallel other indicators of liver damage in chronic hepatitis C patients.
Journal of viral hepatitis 2000;7(3):175-83.
2000: Cecília M P Rodrigues; Clifford J Steer
Mitochondrial membrane perturbations in cholestasis.
Journal of hepatology 2000;32(1):135-41.
1999: Cecília M P Rodrigues; X Ma; Cheryle Linehan-Stieers; G Fan; Betsy T Kren; Clifford J Steer
Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation.
Cell death and differentiation 1999;6(9):842-54.
1999: Cecília M P Rodrigues; Clifford J Steer
Bile acids and hepatocyte apoptosis: living/leaving life in the Fas lane.
Gastroenterology 1999;117(3):732-6.
1999: Cecília M P Rodrigues; J J Marín; Dora Brites
Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment.
Gut 1999;45(3):446-52.
1998: Dora Brites; Cecília M P Rodrigues
Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy [see comemnts].
Journal of hepatology 1998;29(5):743-51.
1998: Dora Brites; Cecília M P Rodrigues; H van-Zeller; A Brito; R Silva
Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal.
European journal of obstetrics, gynecology, and reproductive biology 1998;80(1):31-8.
1998: Cecília M P Rodrigues; G Fan; X Ma; Betsy T Kren; Clifford J Steer
A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.
The Journal of clinical investigation 1998;101(12):2790-9.
1998: Cecília M P Rodrigues; G Fan; P Y Wong; Betsy T Kren; Clifford J Steer
Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production.
Molecular medicine (Cambridge, Mass.) 1998;4(3):165-78.
1998: Dora Brites; Cecília M P Rodrigues; M da C Cardoso; Luís M Graça
Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration.
European journal of obstetrics, gynecology, and reproductive biology 1998;76(2):165-8.
1998: Dora Brites; Cecília M P Rodrigues; N Oliveira; M Cardoso; Luís M Graça
Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy.
Journal of hepatology 1998;28(1):91-8.
1996: Andrea Crosignani; Kenneth D R Setchell; Pietro Invernizzi; Alberto Larghi; Cecília M P Rodrigues; Mauro Podda
Clinical pharmacokinetics of therapeutic bile acids.
Clinical pharmacokinetics 1996;30(5):333-58.
1996: Cecília M P Rodrigues; Betsy T Kren; Clifford J Steer; Kenneth D R Setchell
Formation of delta 22-bile acids in rats is not gender specific and occurs in the peroxisome.
Journal of lipid research 1996;37(3):540-50.
1996: Kenneth D R Setchell; Cecília M P Rodrigues; Mauro Podda; Andrea Crosignani
Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis.
Gut 1996;38(3):439-46.
1996: Cecília M P Rodrigues; Kenneth D R Setchell
Performance characteristics of reversed-phase bonded silica cartridges for serum bile acid extraction.
Biomedical chromatography : BMC 1996;10(1):1-5.
1995: Betsy T Kren; Cecília M P Rodrigues; Kenneth D R Setchell; Clifford J Steer
Posttranscriptional regulation of mRNA levels in rat liver associated with deoxycholic acid feeding.
The American journal of physiology 1995;269(6 Pt 1):G961-73.
1995: Cecília M P Rodrigues; Betsy T Kren; Clifford J Steer; Kenneth D R Setchell
The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation.
Gastroenterology 1995;109(6):1835-44.
1995: Cecília M P Rodrigues; Betsy T Kren; Clifford J Steer; Kenneth D R Setchell
Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate.
Gastroenterology 1995;109(2):564-72.
1995: Kenneth D R Setchell; H Yamashita; Cecília M P Rodrigues; N C O'Connell; Betsy T Kren; Clifford J Steer
delta 22-Ursodeoxycholic acid, a unique metabolite of administered ursodeoxycholic acid in rats, indicating partial beta-oxidation as a major pathway for bile acid metabolism.
Biochemistry 1995;34(13):4169-78.