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Ulrich Bierbach

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Chemicals & Drugs

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Tumor Cell Line

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Publications

TOP 3
Song Ding; Gregory L Kucera; Xin Qiao; Ulrich Bierbach
Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer.
Song Ding; Gregory Kucera; Glen S Marrs; Xin Qiao; Jimmy Suryadi; Ulrich Bierbach
Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents.
Song Ding; Gregory Kucera; Xin Qiao; Ulrich Bierbach
Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents.

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All Publications

2013: Song Ding; Gregory L Kucera; Xin Qiao; Ulrich Bierbach
Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer.
Chemical communications (Cambridge, England) 2013;49(24):2415-7.
2013: Song Ding; Gregory Kucera; Glen S Marrs; Xin Qiao; Jimmy Suryadi; Ulrich Bierbach
Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents.
Angewandte Chemie (International ed. in English) 2013;52(12):3350-4.
2012: Song Ding; Gregory Kucera; Xin Qiao; Ulrich Bierbach
Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents.
Journal of medicinal chemistry 2012;55(22):10198-203.
2012: Jimmy Suryadi; Ulrich Bierbach
DNA metalating-intercalating hybrid agents for the treatment of chemoresistant cancers.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(41):12926-34.
2012: Leigh A Graham; Gregory Kucera; Jimmy Suryadi; Tiffany K West; Ulrich Bierbach
Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents.
Journal of medicinal chemistry 2012;55(17):7817-27.
2012: Xin Qiao; Marcus W Wright; Alexandra E Zeitany; Amal S Essader; Gregory L Kucera; Keith E Levine; Ulrich Bierbach
Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells.
Metallomics : integrated biometal science 2012;4(7):645-52.
2011: Lu Rao; Joshua D Dworkin; William E Nell; Ulrich Bierbach
Interactions of a platinum-modified perylene derivative with the human telomeric G-quadruplex.
The journal of physical chemistry. B 2011;115(46):13701-12.
2011: Jayati Roy Choudhury; Lu Rao; Ulrich Bierbach
Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(3):373-80.
2010: Lu Rao; Tiffany K West; Gilda Saluta; Gregory Kucera; Ulrich Bierbach
Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agents.
Chemical research in toxicology 2010;23(7):1148-50.
2009: Lauren C Eiter; Nathan W Hall; Cynthia S Day; Gilda Saluta; Gregory Kucera; Ulrich Bierbach
Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis.
Journal of medicinal chemistry 2009;52(21):6519-22.
2009: Alexander R Kheradi; Gilda Saluta; Gregory Kucera; Cynthia S Day; Ulrich Bierbach
Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups.
Bioorganic & medicinal chemistry letters 2009;19(13):3423-5.
2009: Zhidong Ma; Lu Rao; Ulrich Bierbach
Replacement of a thiourea-S with an amidine-NH donor group in a platinum-acridine antitumor compound reduces the metal's reactivity with cysteine sulfur.
Journal of medicinal chemistry 2009;52(10):3424-7.
2008: Zhidong Ma; Gilda Saluta; Gregory Kucera; Ulrich Bierbach
Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines.
Bioorganic & medicinal chemistry letters 2008;18(13):3799-801.
2008: Jayati Roy Choudhury; Rajsekhar Guddneppanavar; Gilda Saluta; Gregory L Kucera; Ulrich Bierbach
Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups.
Journal of medicinal chemistry 2008;51(11):3069-72.
2007: Lu Rao; Ulrich Bierbach
Kinetically favored platination of adenine in the g-rich human telomeric repeat.
Journal of the American Chemical Society 2007;129(51):15764-5.
2007: Zhidong Ma; Cynthia S Day; Ulrich Bierbach
Unexpected reactivity of the 9-aminoacridine chromophore in guanidylation reactions.
The Journal of organic chemistry 2007;72(14):5387-90.
2007: Rajsekhar Guddneppanavar; Jayati Roy Choudhury; Alexander R Kheradi; Bartlett D Steen; Gilda Saluta; Gregory Kucera; Cynthia S Day; Ulrich Bierbach
Effect of the diamine nonleaving group in platinum-acridinylthiourea conjugates on DNA damage and cytotoxicity.
Journal of medicinal chemistry 2007;50(9):2259-63.
2007: Rajsekhar Guddneppanavar; Ulrich Bierbach
Adenine-N3 in the DNA minor groove - an emerging target for platinum containing anticancer pharmacophores.
Anti-cancer agents in medicinal chemistry 2007;7(1):125-38.
2006: Rajsekhar Guddneppanavar; Gilda Saluta; Gregory Kucera; Ulrich Bierbach
Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine.
Journal of medicinal chemistry 2006;49(11):3204-14.
2006: Rajsekhar Guddneppanavar; Marcus W Wright; Alyssa K Tomsey; Ulrich Bierbach
Guanine binding of a cytotoxic platinum-acridin-9-ylthiourea conjugate monitored by 1-D 1H and 2-D [1H,15N] NMR spectroscopy: hydrolysis is not the rate-determining step.
Journal of inorganic biochemistry 2006;100(5-6):972-9.
2005: Yan Ma; Cynthia S Day; Ulrich Bierbach
Synthesis, structure, and reactivity of monofunctional platinum(II) and palladium(II) complexes containing the sterically hindered ligand 6-(methylpyridin-2-yl)acetate.
Journal of inorganic biochemistry 2005;99(10):2013-23.
2005: Suzanne M Hess; Amanda M Mounce; Russel C Sequeira; Todd M Augustus; Margaret C Ackley; Ulrich Bierbach
Platinum-acridinylthiourea conjugates show cell line-specific cytotoxic enhancement in H460 lung carcinoma cells compared to cisplatin.
Cancer chemotherapy and pharmacology 2005;56(4):337-43.
2005: Michael E Budiman; Ulrich Bierbach; Rebecca W Alexander
DNA minor groove adducts formed by a platinum-acridine conjugate inhibit association of tata-binding protein with its cognate sequence.
Biochemistry 2005;44(33):11262-8.
2005: Hemanta Baruah; Marcus W Wright; Ulrich Bierbach
Solution structural study of a DNA duplex containing the guanine-N7 adduct formed by a cytotoxic platinum-acridine hybrid agent.
Biochemistry 2005;44(16):6059-70.
2005: Colin G Barry; Cynthia S Day; Ulrich Bierbach
Duplex-promoted platination of adenine-N3 in the minor groove of DNA: challenging a longstanding bioinorganic paradigm.
Journal of the American Chemical Society 2005;127(4):1160-9.
2005: Suzanne M Hess; Joel Anderson; Ulrich Bierbach
A non-crosslinking platinum-acridine hybrid agent shows enhanced cytotoxicity compared to clinical BCNU and cisplatin in glioblastoma cells.
Bioorganic & medicinal chemistry letters 2005;15(2):443-6.
2005: Jayati Roy Choudhury; Ulrich Bierbach
Characterization of the bisintercalative DNA binding mode of a bifunctional platinum-acridine agent.
Nucleic acids research 2005;33(17):5622-32.
2004: Michael E Budiman; Rebecca W Alexander; Ulrich Bierbach
Unique base-step recognition by a platinum-acridinylthiourea conjugate leads to a DNA damage profile complementary to that of the anticancer drug cisplatin.
Biochemistry 2004;43(26):8560-7.
2004: Margaret C Ackley; Colin G Barry; Amanda M Mounce; Michael C Farmer; Beth-Erin Springer; Cynthia S Day; Marcus W Wright; Susan J Berners-Price; Suzanne M Hess; Ulrich Bierbach
Structure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(4):453-61.
2004: Hemanta Baruah; Cynthia S Day; Marcus W Wright; Ulrich Bierbach
Metal-intercalator-mediated self-association and one-dimensional aggregation in the structure of the excised major DNA adduct of a platinum-acridine agent.
Journal of the American Chemical Society 2004;126(14):4492-3.
2004: Hemanta Baruah; Ulrich Bierbach
Biophysical characterization and molecular modeling of the coordinative-intercalative DNA monoadduct of a platinum-acridinylthiourea agent in a site-specifically modified dodecamer.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(3):335-44.
2004: Hemanta Baruah; Colin G Barry; Ulrich Bierbach
Platinum-intercalator conjugates: from DNA-targeted cisplatin derivatives to adenine binding complexes as potential modulators of gene regulation.
Current topics in medicinal chemistry 2004;4(15):1537-49.
2003: Colin G Barry; Hemanta Baruah; Ulrich Bierbach
Unprecedented monofunctional metalation of adenine nucleobase in guanine- and thymine-containing dinucleotide sequences by a cytotoxic platinum-acridine hybrid agent.
Journal of the American Chemical Society 2003;125(32):9629-37.
2003: Hemanta Baruah; Ulrich Bierbach
Unusual intercalation of acridin-9-ylthiourea into the 5'-GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugate.
Nucleic acids research 2003;31(14):4138-46.
2003: Todd M Augustus; Joel Anderson; Suzanne M Hess; Ulrich Bierbach
Bis(acridinylthiourea)platinum(II) complexes: synthesis, DNA affinity, and biological activity in glioblastoma cells.
Bioorganic & medicinal chemistry letters 2003;13(5):855-8.
2002: Colin G Barry; Elizabeth C Turney; Cynthia S Day; Gilda Saluta; Gregory Kucera; Ulrich Bierbach
Thermally inert metal ammines as light-inducible DNA-targeted agents. Synthesis, photochemistry, and photobiology of a prototypical rhodium(III)-intercalator conjugate.
Inorganic chemistry 2002;41(26):7159-69.
2002: Jennifer M Brow; Cynthia R Pleatman; Ulrich Bierbach
Cytotoxic acridinylthiourea and its platinum conjugate produce enzyme-mediated DNA strand breaks.
Bioorganic & medicinal chemistry letters 2002;12(20):2953-5.
2002: Hemanta Baruah; Christopher L Rector; Susanne M Monnier; Ulrich Bierbach
Mechanism of action of non-cisplatin type DNA-targeted platinum anticancer agents: DNA interactions of novel acridinylthioureas and their platinum conjugates.
Biochemical pharmacology 2002;64(2):191-200.
2001: E T Martins; Hemanta Baruah; J Kramarczyk; Gilda Saluta; Cynthia S Day; Gregory Kucera; Ulrich Bierbach
Design, synthesis, and biological activity of a novel non-cisplatin-type platinum-acridine pharmacophore.
Journal of medicinal chemistry 2001;44(25):4492-6.